#=GF ID   AviRa
#=GF AC   PF11599.12
#=GF DE   RRNA methyltransferase AviRa
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_1o9g
#=GF GA   25.70 25.70;
#=GF TC   25.70 25.80;
#=GF NC   25.60 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0063
#=GF RN   [1]
#=GF RM   12742024
#=GF RT   Crystal structure of the avilamycin resistance-conferring
#=GF RT   methyltransferase AviRa from Streptomyces viridochromogenes. 
#=GF RA   Mosbacher TG, Bechthold A, Schulz GE; 
#=GF RL   J Mol Biol. 2003;329:147-157.
#=GF DR   INTERPRO; IPR024268;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins represents the methyltransferase AviRa
#=GF CC   from Streptomyces viridochromogenes. This protein mediates the
#=GF CC   resistance to the antibiotic avilamycin. AviRa methylates a
#=GF CC   specific guanine base within the peptidyl-transferase loop of
#=GF CC   the 23S ribosomal RNA [1].
#=GF SQ   89
#=GS A0A1T5LV92_9CLOT/1-232   AC A0A1T5LV92.1
#=GS A0A3N0E900_9ACTN/1-230   AC A0A3N0E900.1
#=GS M3CC20_STRMB/1-235       AC M3CC20.1
#=GS A0A7X0VUK9_9BACL/1-235   AC A0A7X0VUK9.1
#=GS A0A1H3SVU9_9BACI/1-232   AC A0A1H3SVU9.1
#=GS A0A7W8VEV6_9ACTN/1-230   AC A0A7W8VEV6.1
#=GS A0A6I4VWF2_9BACL/1-229   AC A0A6I4VWF2.1
#=GS A0A841IRN1_9ACTN/1-227   AC A0A841IRN1.1
#=GS A0A0S4IXA1_BODSA/83-307  AC A0A0S4IXA1.1
#=GS A0A0N7JZF6_9PSEU/1-227   AC A0A0N7JZF6.1
#=GS A0A2P8CUW3_9ACTN/1-231   AC A0A2P8CUW3.1
#=GS A0A326U6X4_THEHA/12-244  AC A0A326U6X4.1
#=GS A0A7W3QKB7_ACTNM/1-234   AC A0A7W3QKB7.1
#=GS A0A136PPG4_9ACTN/1-233   AC A0A136PPG4.1
#=GS A0A3B0CFR5_9BACL/3-236   AC A0A3B0CFR5.1
#=GS A0A4Q2LP36_9BACL/1-236   AC A0A4Q2LP36.1
#=GS W2EII2_9ACTN/1-95        AC W2EII2.1
#=GS A0A1Q9TV68_9ACTN/1-229   AC A0A1Q9TV68.1
#=GS A0A4V2WPU6_9BACL/1-60    AC A0A4V2WPU6.1
#=GS A0A4R4M8E3_9ACTN/1-233   AC A0A4R4M8E3.1
#=GS A0A6C0FVW6_9BACL/1-237   AC A0A6C0FVW6.1
#=GS A0A151YYY3_9BACL/1-230   AC A0A151YYY3.1
#=GS A0A061P0B3_9BACL/7-236   AC A0A061P0B3.1
#=GS A0A7W7RMI2_9ACTN/1-230   AC A0A7W7RMI2.1
#=GS A0A2V2YVF5_9BACL/1-239   AC A0A2V2YVF5.1
#=GS A0A4R6V306_9ACTN/1-230   AC A0A4R6V306.1
#=GS A0A543NN87_9ACTN/1-232   AC A0A543NN87.1
#=GS A0A124H0X9_9ACTN/1-235   AC A0A124H0X9.1
#=GS D2AWL7_STRRD/1-234       AC D2AWL7.1
#=GS A0A269W5I9_9BACL/1-233   AC A0A269W5I9.1
#=GS A9KJB4_LACP7/1-224       AC A9KJB4.1
#=GS A0A370I5T1_9NOCA/1-227   AC A0A370I5T1.1
#=GS C4RPB1_MICS3/1-235       AC C4RPB1.1
#=GS A0A1R3UKD8_9ACTN/1-228   AC A0A1R3UKD8.1
#=GS A0A6P1TUR6_9FIRM/1-105   AC A0A6P1TUR6.1
#=GS A0A553ZFN0_9ACTN/1-233   AC A0A553ZFN0.1
#=GS A0A0M8XW25_9ACTN/1-215   AC A0A0M8XW25.1
#=GS A0A4P6JK52_9CHLR/1-245   AC A0A4P6JK52.1
#=GS A0A4R1HGD8_PSEEN/1-225   AC A0A4R1HGD8.1
#=GS A0A1C6UV85_9ACTN/1-236   AC A0A1C6UV85.1
#=GS A0A238YKX9_9ACTN/1-234   AC A0A238YKX9.1
#=GS A0A429B9G1_9ACTN/1-235   AC A0A429B9G1.1
#=GS R9KK57_9FIRM/2-90        AC R9KK57.1
#=GS A0A4Q7V7U4_PSEST/8-194   AC A0A4Q7V7U4.1
#=GS V9GBS0_9BACL/1-237       AC V9GBS0.1
#=GS A0A1T4R189_9ACTN/1-230   AC A0A1T4R189.1
#=GS J7LF16_NOCAA/1-228       AC J7LF16.1
#=GS A0A7S8IEC2_9CHLR/1-226   AC A0A7S8IEC2.1
#=GS R9KC37_9FIRM/1-97        AC R9KC37.1
#=GS A0A1I1FU39_9FIRM/1-155   AC A0A1I1FU39.1
#=GS D7AX50_NOCDD/1-231       AC D7AX50.1
#=GS A0A419HR07_9PSEU/1-218   AC A0A419HR07.1
#=GS A0A343JFC4_9CLOT/1-232   AC A0A343JFC4.1
#=GS A0A223SEA5_9ACTN/1-232   AC A0A223SEA5.1
#=GS L0EEW0_THECK/1-237       AC L0EEW0.1
#=GS A0A6P1TQD5_9FIRM/1-129   AC A0A6P1TQD5.1
#=GS A0A853BST6_9ACTN/1-233   AC A0A853BST6.1
#=GS A0A0C2G8J6_9ACTN/1-230   AC A0A0C2G8J6.1
#=GS A0A1M6NSQ1_9ACTN/1-229   AC A0A1M6NSQ1.1
#=GS A0A1H2ZGU3_9FIRM/1-225   AC A0A1H2ZGU3.1
#=GS A0A0H5SGT4_HERHM/1-224   AC A0A0H5SGT4.1
#=GS A0A2A2YZN3_9ACTN/1-234   AC A0A2A2YZN3.1
#=GS A0A1I5JKD5_9ACTN/1-233   AC A0A1I5JKD5.1
#=GS A0A3S9A2R3_9BACL/1-235   AC A0A3S9A2R3.1
#=GS A0A4P6Q6L0_9ACTN/1-230   AC A0A4P6Q6L0.1
#=GS A0A840WS48_9ACTN/1-229   AC A0A840WS48.1
#=GS D1BGB8_SANKS/1-223       AC D1BGB8.1
#=GS A0A061PHI3_9BACL/1-230   AC A0A061PHI3.1
#=GS A0A091CDM9_9ENTE/1-233   AC A0A091CDM9.1
#=GS A0A2T0ML69_9ACTN/1-234   AC A0A2T0ML69.1
#=GS A0A1B1ZMM7_9PSEU/1-185   AC A0A1B1ZMM7.1
#=GS A0A7W1XUG8_9BACL/1-231   AC A0A7W1XUG8.1
#=GS A0A3A8YBF5_9BACT/1-230   AC A0A3A8YBF5.1
#=GS A0A1I4SM55_PSUAM/1-190   AC A0A1I4SM55.1
#=GS A0A221W1A9_9PSEU/1-195   AC A0A221W1A9.1
#=GS A0A7I8DQZ9_9FIRM/1-224   AC A0A7I8DQZ9.1
#=GS A0A0N1NBN1_9ACTN/1-245   AC A0A0N1NBN1.1
#=GS A0A5B2XG26_9PSEU/1-235   AC A0A5B2XG26.1
#=GS D3EHE3_GEOS4/1-237       AC D3EHE3.1
#=GS A0A1R1F2M5_9BACL/1-235   AC A0A1R1F2M5.1
#=GS G4L5U2_TETHN/1-235       AC G4L5U2.1
#=GS A0A5C8JSV3_9ACTN/1-235   AC A0A5C8JSV3.1
#=GS A0A060LXB2_9BACI/1-229   AC A0A060LXB2.1
#=GS A0A2K2FAS2_9FIRM/1-231   AC A0A2K2FAS2.1
#=GS A0A1Y2MXF1_PSEAH/1-234   AC A0A1Y2MXF1.1
#=GS A0A852U248_9ACTN/1-230   AC A0A852U248.1
#=GS A0A0M4QLW8_9PSEU/1-190   AC A0A0M4QLW8.1
#=GS A0A5C4TI67_9BACL/11-245  AC A0A5C4TI67.1
#=GS A0A7R7ICH8_9FIRM/1-226   AC A0A7R7ICH8.1
A0A1T5LV92_9CLOT/1-232              ....................MKYKFETNKRDYSDFSS.GRVLYYAANTTAFPVRLASE.VIQR.SFDILEK.....KGAHg...pFKIYDPCCGGG.FLL.TT.I.GFLYHD...L..I.S.ELIATDYDDKV..LE.IAK.KNLSLLSKKG.LDRRKEEIKGYIKAF..GKESH.MQALKSVDYLETLI....--..KKEAIKIVC.MQRD...IAD.L...S.DF.PI..KG.........VNIIITDIPYGIIVDWRGG........RKDP..IQNLFENS...YNALDKKRSVLVIIADKKSKLKH..KSFE...RTQYFKLGKR..........................................................
A0A3N0E900_9ACTN/1-230              ....................MAYRYATERVDHTDLAS.GYVLRSVPGQPGFPARLASE.LFQR.SLAHLD-.....ADP-.....VGLWDPCCGGG.HLA.AV.L.ALLHRD...R..L.A.HVHASDVDGDS..VR.IAA.RNLDLLTERG.MAERERELRAGAVEF..AKPAF.SDRAEAARRLAEWL....RS..RGGDLRHSV.WEAD...AFA.P...V.PP.ER..-R.........VDLVLTDVPYGNLAHWAGAr......pAGDE..VHALLRAL...SGVL-PAEAVLTVTARARRVDLP..RGVR...ALERVRVGNR..........................................................
M3CC20_STRMB/1-235                  ..................ms-SYRHAVERSDSSDLAC.GVVLHSAPGYPAFPVRLATE.IFLR.AQARLPD.....DGP-.....VTLWDPCCGSG.YLL.TV.L.GLLHRR...A..L.R.RVIASDVDPAP..LE.LAA.KNLALLSPGG.LAAREAERREQSERF..AKPAY.QESADAARRLRDRL....EA..DGGALPYAV.GAAD...VFD.P...R.SL.SA..VVag.....aaPDVVLTDLPYGERTHWDGA.......vPGQP..VTGMLRSL...ASVL-PAHAVIAVTDRSRKIPVA..P-VP...ALERLKIGTR..........................................................
A0A7X0VUK9_9BACL/1-235              ....................MDYLFETVPRNYETFAS.GRVLYNARGTTAFPVRLASE.IAQR.CFRILEG.....KGEPg...pYSVYDPCCGGG.YLL.TV.V.GLLHGP...R..I.G.SLQGSDVDGEA..LG.IAA.QNLSLLTKDG.LDRRKDQLRKLYELY..GKTSH.REALASAEELDERI....-R..SSGIERIAT.FQAD...ATS.P...E.NR.AD..MPg.......gVHLVMTDLPYGNLAEWRSE........SRDP..LPEWFETV...RRTMIPSRSVLAVVADKGQKLAH..GKFR...RLQHLKVGKR..........................................................
A0A1H3SVU9_9BACI/1-232              ....................MKFKYEVEKKDHRDFSS.GRVLINAPQTPAFPVRIASE.IMSR.CLSYINS.....NDC-.....ISIYDPCCGGA.HLL.TV.I.GFLYRE...K..I.E.RVYGTEIDIKA..VG.YAK.RNLNLLTSNG.LFQRKKNILQNYNKF..GKVSH.LEALQSVKRLISTT....LD..SNHIKDIQC.LDWD...ITS.S...K.PP.VF..RN.........INIVITDLPYGNMAIWKGT.......kNMNP..IEQMLKNV...YYTLDLNNAVVSIICDKNQKVEH..EWFE...QVKRLKHGKR..........................................................
A0A7W8VEV6_9ACTN/1-230              ....................MAYRFATDRADRSDLAS.GAVLRSAPGHPGYPVRLAEE.LLGR.VLSHLPR.....RPA-.....-GLWDPCCGSG.HLA.TA.L.GLLHRS...E..L.A.HVLAGDADPDA..VG.IAR.RNLALLAPGG.LAERERELLAAGAET..GRESF.AGRAAAARRLAALL....EA..GGGPLPAEA.RVDD...AFR.P...A.PP.PR..P-.........VDAVITDVPYGGLARWHGAp......dGAEP..VPALLAAV...AGVL-PDHAVLALSARARKVPLP..AGVA...ALERVRVGNR..........................................................
A0A6I4VWF2_9BACL/1-229              ....................MIYKYEMEKEDYSDFAS.GRVLHNAPNTTGFPARLGKE.IMSR.CLTQLRT.....DKN-.....LILYDPCCGGA.HLL.TF.I.GFLYRE...H..F.A.EIYGSDIDEQV..LE.YAK.RNLKLLTEEG.LLARKEQLQRDFDIY..QKESH.LHALESVERLERLN....--..QTAVKQLQC.FPFH...IAG.I...T.RP.PI..QN.........VNIVFTDLPYGNIVDWKGS........KDNH..IQQMLTNI...YQILDLNNSIVAIVCDKKQKVIH..GNFE...KIHAFHHGKR..........................................................
A0A841IRN1_9ACTN/1-227              ....................MGYRYALERQDNSVLAS.GHVLRSAPGFPGFPVRLADE.LFRR.AMVHT--.....GDGS.....VRLWDPCCGSG.YLA.TV.L.GLLHRD...R..I.S.SVRASDADPDA..VQ.LAA.RNLRLLTAEG.LAEREEELRRSARDF..GRPSF.VERAEDARALAERL....AA..AGGDLPHEA.AVAD...VFS.S...E.EV.--..-G.........ADLVVTDVPYGEMTHWLGD.......vPENP..LAALFASL...GRVL-PAHAVVVVTARTRRIALP..EGVL...ALERVRVGNR..........................................................
A0A0S4IXA1_BODSA/83-307             ........lemykrfpqeyd-----------------.---LLMAKHDCTQLNRLFGD.LMED.VRQRLRS.....AEHG.....LRMIDLGCGTG.RLL.CAaL.SEAAAR...RipL.S.LLIGYDKEAAM..LR.IAL.ANMQKQQ-QQ.QQRRESEPDAVDSRE..ATETI.TEALQSIDRAEDWS....SS..SSGTTTTCL.RPFD...FLH.V...R.QG.AL..HAphp...thhIAVCAWSLSYVMRSCWGGD.......rWHQE..LRDTVDAI...VASVVDGGAVVII----------..----...----------etlgngcetptrrnvm..........................................
A0A0N7JZF6_9PSEU/1-227              ....................MQYRHAPAAN---HAAL.DAVLVSAPGRPTLPVRLTVE.LAGR.ARERL-G.....PGP-.....VTVWDPCCGAG.VSL.AV.L.GLLCP-...G..I.A.VLAGTDADPAP..LG.LAR.RNLGLLAPGG.LDDRASTLDGLAARH..GKESC.AVAAAAARATIPAS....--..---RPEWRV.GVAD...AGD.-...-.PE.AV..RTalg...giePDLVLADLPHGRQTSWAGEp.....gtGPPP..EAGFLVAV...AEPL-HAEAVVVAVGRGRSVPLP..PGVR...PLERIRAGHR..........................................................
A0A2P8CUW3_9ACTN/1-231              ....................MSYRHAIERIDHSDLAS.GQVLHSAPGHPGFPVRLASE.LFQR.AAALLPG.....TGP-.....AALWDPCCGSG.YLA.AV.V.GLLHRD...R..V.A.HVLATDVDPGA..AA.LAG.RNLALLTGAG.LAAREAELRARAAEF..GKPSY.AATADSAARLAGRL....AA..AGGDLAHEA.RTGD...VFA.P...V.AP.AV..P-.........VDVVLTDVPYGALTHWAGAv......pAGDP..VAVLLTGV...AGVL-PGHAVLAVAARARRVAVP..DGVP...ALGRVRVGNR..........................................................
A0A326U6X4_THEHA/12-244             ....................MTYRFTQEKQDYSDLAT.GRVLYSVPGRVAFPVRLASE.LFQR.CLSLYQQ.....RGGTt...pCVLYDPCCGGA.SLL.VS.V.GFLHGS...K..L.S.AVIGSDADPDV..LP.LAE.KNLALLTPQG.LEQRIAQLQTLYQEY..GKPSH.AEALESAYRLQRQL....--..--MPLTIGL.FQAD...VMR.P...L.DP.TRfpKS.........VDLVMVDLPYGQHTGWLHAs......aAQDP..ATALLDSL...RSIL-SPAAVVALITTKQHKVVH..EQFR...RLEQFSIGKR..........................................................
A0A7W3QKB7_ACTNM/1-234              ....................MGYTHVAVKGDYTDLAS.GSVLRSAPGFPAFPVRLASE.IFLR.ARTLRGG.....DAP-.....AVVWDPCCGSG.YLL.ST.L.GLLHRA...E..I.T.SLVAGDIDDEA..LE.LAR.ENLGLLDPDA.LEGRAKALEDRAERF..GKPSY.LEAAEAARRLGASL....AA..QGGRLPTTA.HRAN...VFD.P...A.TL.KT..ALge.....ttPDIVITDIPYGEQTTWQGT........DGAG..VPEMLRAV...ASVL-TGDAVLAIATRGRKVPLD..GACR...PDQSFRIGTR..........................................................
A0A136PPG4_9ACTN/1-233              ....................MTYRFATERPDYSDLAS.GAVLRSAPGHPAFPVRLASE.MFLR.AWHALGR.....PR--.....VTVWDPCCGSG.YLL.TV.L.GLLHRE...R..I.A.GIVASDVADGP..LR.LAR.ANLGLLSADG.LQDRAAELDELADRF..QRPAH.RTAAEAARRLRAQL....--..TPGDPATVV.GRAD...ALV.P...E.QV.AD..LLaa....sgpPDLVLTDVPYGEQTTWQGA.......dPAAG..LPGLLDSL...AGAL-PAETMVALATRGRRVPLP..AGTR...TAARFKIGTR..........................................................
A0A3B0CFR5_9BACL/3-236              ...................v-NYRHAVERHSFEDLAS.GRVLYNGRGTTAFPVRLASE.LFSR.AAAYLTG.....RGNAg...pYRLYDPCAGGA.YML.TA.I.GFLHGD...L..I.A.DIAASDIDPQA..VE.LAA.RNLSLLTAEG.LNERVRQLRELYDSY..GKTSH.SEALDSAERLGAII....AS..HPERPATAC.LAAD...ATE.P...I.GA.LQ.gRQ.........FDMIVSDLPYGHLVDWTTE........AEHP..ARQMLDRL...APLL-TPVSVVVLVAPKEQKITN..DRYE...QVGQFKVGKR..........................................................
A0A4Q2LP36_9BACL/1-236              ....................MEYKYETVSRSFEDFAS.GKVLFNARGTTSFPVRLGSE.IYLR.AKSYLRS.....TGNKd...rITLYDPCCGGA.HLL.TA.I.GILHGH...D..M.K.RMIGSDIEPDV..VE.VAI.RNLGLINLDG.INARMEQLTQMVNEF..GKDSH.RQAVESARRLKEQI....VQ..RNTTLTATC.FQAD...ATA.E...A.EY.DD..RSl......gaVDMVITDLPYGNMVKWTSD........SANP..AEKLLENL...LPRL-SSDAVVAVIADKKQVIQN..ANYK...RLQKFKIGKR..........................................................
W2EII2_9ACTN/1-95                   ...............lpaea-----------------.--------------------.----.-------.....----.....-----------.---.--.-.------...-..-.-.-----------..--.---.----------.---------------..-----.--------------....--..---------.RRAD...VFD.A...G.GL.RE..VLgg.....rrPGVVVTDVPYGEQTSWLGP.......dGESG..AAGMLRTL...GAVL-PEGAVIAVAVRGRRPPRA..DGADglvPRGSFKIGTR..........................................................
A0A1Q9TV68_9ACTN/1-229              ....................MGYRYAVERADHSALAS.GQVLRSAPGYPGFPVRLASE.LFQR.GLAHV--.....HDSP.....VRLWDPCCGGG.YLL.TV.L.GLLHRD...R..V.S.HVRASDVDADA..VD.LAA.RNLELLTASG.LATREAELRRSARDF..GRVAF.VERAEAAANLAAGL....AA..MGGDLPHDA.AVAD...VFA.L...G.EP.VG..--.........ADLVVTDVPYGEMTRWSGGv......pGEDP..VGALLASL...GRVL-PERAVVVVAARTRRIALP..EGVR...ALERVRVGNR..........................................................
A0A4V2WPU6_9BACL/1-60               ....................MEYIYENQRDTYEDFAS.GRVLLNASGTTAFPVKLASE.IFLR.GRSYLRS.....RSEKk...kYSL--------.---.--.-.------...-..-.-.-----------..--.---.----------.---------------..-----.--------------....--..---------.----...---.-...-.--.--..--.........-------------------........----..--------...-----------------------..----...----------fae.......................................................
A0A4R4M8E3_9ACTN/1-233              ....................MTYRFATERPDYSDLAS.GAVLRSAPGHPAFPVRLASE.MFLR.AWHALGR.....PR--.....LTVWDPCCGSG.YLL.TV.L.GLLHRE...R..I.A.GIVASDVADGP..LR.LAR.ANLGLLSADG.LTDRAAELDELADRF..QRPAH.RTAAEAARRLRAQL....--..TPGDPPTVV.GRAD...ALD.P...E.QV.AA..LLaa....sgpPDLVLTDVPYGEQTTWQGT.......dPAAG..LPGLLDSL...AGAL-PAGTMVALATRGRRVPLP..AGTR...TAARFRIGTR..........................................................
A0A6C0FVW6_9BACL/1-237              ....................MEYVYEQVRHNYEDFSS.GRVLLNAGGTTAFPVRLASE.LYLR.AKSYLPP.....ERGEq...pITIYDPCCGGA.YLL.TT.L.GLLHGQ...G..I.G.RLVGSDIDGKA..VE.LAK.RNLAMANPEG.IAERLAQLTALYAAF..GKTSH.KEAIESAERLQERI....AR..RNSRIETVC.FQAD...ATG.E...R.AD.YW..NAgg.....qaADIVMTDVPYGNVVTWSSE........DADP..LDSLLNHL...LGVV-RAGSVVVVVADKKQAIAH..PAYK...RLEKLKIGKR..........................................................
A0A151YYY3_9BACL/1-230              ....................MKYHYEIEKKDYRDFAS.GRVLYNVPGSAPFPVRLASE.IFYR.AQSFLNE.....EKNG.....FKLYDPCCGSG.YLL.TV.L.GFLHAS...K..I.R.EIAASDDDEKM..VA.FAR.KNLSLLSFAG.LRRREEEIRKYVKEY..GKPSH.IEALDSVQVLKAYL....--..KKEPIQITC.FQRD...ITK.P...D.EN.PV..QR.........VQVIITDLPYGNLVSWRGN........DENP..VQSLFENL...WKAMDLNNSVAVIITGQKIKPEH..EGFN...RVHHFKVGKR..........................................................
A0A061P0B3_9BACL/7-236              ....................MNYKYETENKDYRDFAS.GRVLLNAKKTTAFPIRMASE.IMQH.CIASLEK.....KES-.....LTLYDPCCGGA.HLL.TA.M.GFIHGK...A..I.K.AIYGSDFDRDV..IE.VAT.TNLSLLTDDG.LIKRENQLSSLFNTY..GKESH.KEALESVGRLRSMS....-A..QMTSPIISS.FTWD...ITG.G...P.PP.VN..EK.........VDIVITDIPYGNTVGWQTT........SSDP..VQDLLGHL...ELIMNKEDSIIAIVSEKKETITH..DRFE...KVKTMKHGKR..........................................................
A0A7W7RMI2_9ACTN/1-230              ....................MAYRYATERADHTDLAS.GHVLRSAPGHPGFPARLASE.LFQR.ALAHL-D.....A--G....pVGLWDPCCGSG.HLL.AV.L.GMLHRG...R..L.V.HVHASDVDSEA..VR.IAA.RNLDLLTAQG.MAERERELRAQAVEF..GRPSF.ADRAGAAQRLAARL....RA..HGGDLPHSA.CEGD...AFA.P...S.PP.QR..-R.........VDLVLTDVPYGDLAHWAGAs......pAEDE..VPELLRAL...SAVL-AERTVLAVTARTRRIGLP..RGTR...ALERVRVGNR..........................................................
A0A2V2YVF5_9BACL/1-239              ....................MEYRYEAEPRSYEDYAS.GRVLLNAQGTTAFPVRLASE.IYQQ.GKAYLAN.....KGRTs...gYTLYDPCCGGA.HLL.TS.I.GIRHGG...D..L.K.RVVGSDVDQRV..LD.IAA.RNLAMVNPDG.MQTRIVQLQELVQAY..GKSSH.QEAVESAERLLALV....EQ..RNRTVDVQC.CIYD...AIG.Q...PsSS.AV..LDel....ngqVDFVFTDVPYGDIVQWSAD........SADP..IGRLLGNL...MPRL-APVSVVAIVADKKQSVDH..LAFR...RLKKLKVGKR..........................................................
A0A4R6V306_9ACTN/1-230              ....................MGYRYATDREDHTDLAS.GQVLRSAPGYPGFPVRLGSE.LAQR.AMARLPS.....--RP.....LVLWDPCCGSG.YLA.TV.V.GLLHRD...R..L.A.RVLASDVDAEA..VR.LAG.RNLRLLTAEG.LAERAAEARGRAAGF..GKPSY.LAVAESADRLARGL....AE..RGGDLAHTV.ERAD...AFA.P...S.GP.PV..P-.........VDLVLTDVPYGDLTHWSGAr......pDAEP..VPALLRAL...AAVL-PDHAVLAVTARTRRVPLP..GGVP...ALERARVGNR..........................................................
A0A543NN87_9ACTN/1-232              ....................MGYRYARQRADHTDLAQ.GCVLRSAPGYPGFPVRFASE.LLQR.AAARVEH.....DGP-.....VGMWDPCCGSG.YLA.TV.L.GLLHRE...R..L.A.RVLASDVDADA..VA.VAE.RNLDLLAEGG.LRRRERELRADAERF..GKPAL.TERAEAARRLAGRF....SR..AGGALPAVV.RRQD...AFA.P...D.PP.DV..P-.........VDVVLTDVPYGGLSQWRGLa.....paETEP..AVSLMAAL...ASVL-PGGAVVGVTARTRKVPLP..AGVS...PLERVRVGNR..........................................................
A0A124H0X9_9ACTN/1-235              ..................ms-AYRHAVERIDSSDLAC.GVVLHSAPGYPAFPVRLATE.IFQR.AVARLPG.....DGP-.....VTLWDPCCGSG.YLL.TV.L.GLLHRR...S..L.R.QVIASDVDPAP..LE.LAA.KNLALLSPAG.LTARELERREQSERF..GKPSY.LEAAQAARRLRERL....TA..EGGALPCAI.RTAD...VFD.P...R.AL.S-..-Avia...gsaPDVVLTDLPYGERTHWEGQ.......vPGQP..VAGLLRSL...ASAL-PAHAVIAVTDRSRKIPVA..P-VR...ALERLKIGTR..........................................................
D2AWL7_STRRD/1-234                  ...................m--YRHATVRGDYEDLAS.GAVLHSAPGFPAFPVRLASE.AFQR.ALALRGG.....GGP-.....ATVWDPCCGSG.YLL.TV.I.GLLHRG...R..I.Q.ALLASDVSDDA..LR.LAR.ANLDLLGQAG.LSARAGVLREKAERF..AKPSY.AAAAEAAGRIGRML....AA..GGGDVPHDV.RRAD...VFD.P...G.QL.AE..AAag.....yaPDIVVTDVPYGEQTTWQGP.......gGDSG..VPGMLAAL...APVL-TERAVVVVTARGRKVPLG..GRIR...ARESFKVGTR..........................................................
A0A269W5I9_9BACL/1-233              ....................MEYIYESAQRSYEDFAS.GRVLYNARGTTSFPVRLASE.IVQR.CLRMLED.....RGNEg...pYTLFDPCCGGG.YLL.TV.A.GLLHGQ...R..F.K.QVIGSDVNAGV..LE.LAG.NNLSLLTPEG.MQRREKQIKELIQLY..DKPSH.HEALQSVARLEQLL....-D..RSAIEEVRC.FQGD...ITN.W...Q.EP.FD..LK.........ANLVLTDLPYGQIVSWNGD........SADP..VHDFFEHV...YRLLEPGRAVVAVIADKSQKLRH..DRFT...KIQGFKVGKR..........................................................
A9KJB4_LACP7/1-224                  ....................MEYKY-TKNDNYEDFAS.GRVLYHVGGEPTFPVRLALE.IYER.CLQYSIK.....KAE-.....ISLYDCCCGGA.YML.SI.L.GLLKSN...T..I.A.NLYGSDINSES..IQ.LAN.DNLGLLTKSG.INKRRDELKALYQTY..KKASH.IDALHSIDRIEELL....--..-TREIKTYL.FKGN...VLE.V...C.DL.PF..T-.........PDIIITDVPYGNMVEWEEG........SG-G..INQMMNAL...SAVC-GSDTIICVCMDKKQKIHN..DIFQ...RLERQLVGKR..........................................................
A0A370I5T1_9NOCA/1-227              ....................MAYRFAVERTDYGDLAS.GAVLRSAPGLPAFPVRLASE.IFQR.AVELRGG.....EQR-.....AVVWDPLCGGG.YLL.TV.L.AMLHRE...R..I.A.GLIASDVDERA..LE.VAR.ANLGLLTAAG.LAARRGELADLADRY..GKAAH.LSALAAADRLTGSG....--..--GDLVASL.GRAD...VFD.T...A.AL.RA..LLap.....mpPDVVVTDIPYGEQVSWQGG........GK--..VEALLESL...DSVL-PADAIVAVTGRG-RRIES..GRFR...PARSFRVGTR..........................................................
C4RPB1_MICS3/1-235                  ....................MTYRHETVRGAYGDLAS.GAVLRSAPGFPAFPVRLASE.VLQT.ALELRPT.....SAP-.....ATVWDPCCGSG.YLL.TV.L.ALLHRP...S..L.A.GLLASDVDEAA..LD.LAR.ANLGLLTGAG.LDTRARELAQRAEAF..DKPHY.AEAAAAAHRLRARL....DA..AGGPLPYAV.RRAD...VFD.R...V.AL.TE..AVag.....mtPDLVVTDLPYGEQTSWQGE.......rAGEG..LPGMLTRV...ASVL-PPTGVLAVVLRGRKVPPV..GEVR...PRRRLRVGTR..........................................................
A0A1R3UKD8_9ACTN/1-228              ....................MSYRYATERTDHSALAS.GQVLRSAPGFPGFPVRLASE.LLQR.AMVHLGE.....DRA-.....-RLWDPCCGSG.YLV.TV.L.GLLHRD...L..L.T.HVRASDVDADA..VA.IAT.RNLELLTAEG.LAERERELRRSALDF..GRVTY.VERAEAARDLAAGL....AA..TGGDLPHES.AVAD...VFT.L...T.EP.VD..--.........ADLVVTDVPYGEMTRWEGE.......tPQDP..VPGLLSSM...GRVL-PERSVVVMTARTRRVQLP..EGVR...ALERVKVGNR..........................................................
A0A6P1TUR6_9FIRM/1-105              ....................MEYRY-SNNKNFEDFAS.GRVIYNYKGITNFPARLAQE.IFGR.CLEYSNK.....KND-.....IGIYDCCCGGG.YML.TI.L.GFMNAD...I..I.S.EITGSDINPDA..VT.KAK.TT--------.---------------..-----.--------------....--..---------.----...---.-...-.--.--..--.........-------------------........----..--------...-----------------------..----...----------wnycmqtdlin...............................................
A0A553ZFN0_9ACTN/1-233              ....................MAYRYATERVDHSDLAS.GFVLRSAPGFTAFPVRLASE.TFQR.ALTLRGG.....DEP-.....AVLWDPCCGKG.YLS.TV.V.GLVHRD...R..I.A.AVVASDIDDAS..LE.IAR.ANLALLTARG.LADRAAEQAGKAARF..GKPGY.TEAAAAAERLAARL....AA..DGGDLPHTV.HHAD...VFD.P...S.AL.ER..AAag.....faPDIVVTDVPYGERVQWQGA........SDTG..LPGMLTSL...ARVL-PERGVIAIGIRGRKFPPV..PGVA...S-RKFRVGTR..........................................................
A0A0M8XW25_9ACTN/1-215              ...................m---------------AS.GNVLRSAPGFPGFPVRLASE.LFQR.GLAHVPR.....--EP.....VRMWDPCCGSG.YLV.TV.L.GLLHRD...R..I.V.HARATDVDPDA..VA.LAA.RNLALLTREG.LAEREEELRRSALDF..GRAEF.VGRAETAGALAAGL....AS..MGGDLPHET.GVAD...VFT.L...S.EP.VE..--.........ADLVVTDVPYGDLTHWRGEa......pGDDP..MAALLASL...GRVL-PPHAVIVVTARTRRVVLP..PGVR...ALERVKVGNR..........................................................
A0A4P6JK52_9CHLR/1-245              ....................MPYHFARENQDFSDFAT.GRVFYSLPGHPAFPPRLASE.IFQR.CLALRTR.....QEMSa...pCVVYDPCCGSA.SLL.SA.I.GYLHWS...V..I.R.HLIGSDIDAEA..LK.LAE.RNMALLTLEG.LNQRCAELRTRAEQY..GRASY.EQAINSVQRLRQRL....QVmlKTHELSATL.FHTD...ATA.G...S.AL.CQ..KLgk.....qtVDIVLSDLPYGQQSSWRSAepa..pgeVLEP..VRQLLTAL...LPVL-ATHAIVALVTSKQQKVQH..EAYR...RLSRFELGKR..........................................................
A0A4R1HGD8_PSEEN/1-225              ....................MRYHHAPAAD---HGAL.DAVLVSAPGRPTLPVRLTLE.LFGR.ALSFVGD.....GTGP.....VTVWDPCCGAG.TTL.AV.L.GLCRGS...V..L.S.GLLGSDVDPSP..LD.LAR.RNLALLDPGG.LDGRARDLDALAARH..GKASY.TGAASAVRGLGGAP....--..----VSHEV.AVAD...ATD.PaatA.PLvAR..HR.........PHVVIADLPHGIRTSWSGS........DD-A..ASELVTAL...AAVL-TPDAVIAMAGLGRKLVLP..SGTR...ALDRLRVGHR..........................................................
A0A1C6UV85_9ACTN/1-236              ....................MTYRFVAERHDYSDLAS.GAVLRSAPGHPAFPVRLASE.VFLR.AWHALGQ.....SRP-.....LTVWDPCCGGG.YLL.TV.L.GLLHRD...K..I.A.AVVASDIADGP..LR.LAR.ANLALLSAEG.MRRRTAELEDLARRF..GRPSY.RESAEASRRLQALL....AQ..GGGDLPYVV.GAAD...ALD.Q...Q.QV.SA..LLta....sppPGLVLTDLPYGEQTSWRGA.......pQEAG..LSGLLGTL...GSVL-PADAMVALTTRGRRVGLP..AGVR...ATARFKIGTR..........................................................
A0A238YKX9_9ACTN/1-234              ....................MAYRYAVVRQNHEDLAS.GGVLHSAPGFPAFPVRLASE.MFQR.ALALLRE.....DEA-.....-TVWDPCCGSG.YLL.TV.L.GLLHHR...Q..I.T.AVLGTDVDTEA..LR.LAA.QNLSLLDEAG.LTARAADLDARAERW..DKPSY.AAPARAARRLAREL....RT..GRGGVGHAV.RPAD...VFD.P...E.QL.RR..-Ald....garPGLVITDVPYGEQTDWRGP.......gGASG..VAGMLRAL...GAVL-PEEAVIAVAVRGRRLRLD..DGLR...ADSSFRIGTR..........................................................
A0A429B9G1_9ACTN/1-235              ....................MSYRHVLTKGDYSDLAS.GSVLRSAPGFPAFPVRLASE.IFLR.ALALRGG.....DAP-.....AVVWDPCCGSG.HLL.SV.V.GLLHRR...L..I.A.SLVASDISANA..LD.LAA.ANLLLLDPDA.LEARARVLEERAERF..DKPSY.LEAAGAARRLGGGL....AA..AGGSLPSLV.RRAD...VFD.R...D.EL.AA..VTaa.....ttPDIVITDVPYGEQTNWLGG.......hGEAG..VPEMLGNV...ASVL-PGEAVLAVTARGRKVPLG..AGPR...PRKEFRIGTR..........................................................
R9KK57_9FIRM/2-90                   .................fsh-----------------.--------------------.----.-------.....----.....-----------.---.--.-.------...-..-.-.-----------..--.---.----------.---------------..-----.--------------....--..---DVSAEI.FEAD...CTK.A...L.PQ.VF..--.........PDIIITDVPYGNLVEWDSG........ELIA..IDLMLEQL...W-TISHENTILAICMNKKQKINC..SKWK...RLEKQSIGKR..........................................................
A0A4Q7V7U4_PSEST/8-194              ..........vqyrhapgan--------------FADlDAVLASAPGRPSLPVRLTLE.LFGR.CHEQLGD.....PGP-.....VVVWDPCCGTG.QLL.TT.L.GLLRRD...E..V.A.ALVGSDADPEP..LA.LAA.RNLALLTPGG.AEARAAELDALAWQH..GKPGY.SDAAAAARRLDPAR....--..EGPPSEVTVaDAFD...PAAtG...G.IV.AR..HR.........PMVVLADLPYGRQTNWAGR........AAAP..Q-------...-----------------------..----...----------pda.......................................................
V9GBS0_9BACL/1-237                  ....................MEYLYESVQRSYEDYAS.GRVLYNAHGTTSFPVRLASE.IAQR.CFHILEQ.....KGAGg...pYSLYDPCCGGA.YLL.TV.L.GLMHGQ...R..F.S.SVIGSDVNPEV..LA.IAN.KNLSLLTHQG.LDHRIGQLQELFERY..HKPSH.QEALQSAARLKVLL....-D..RSRLEDASC.YPAD...ITD.S...Q.SQ.AA..LNrp.....agIHMVITDLPYGDIVSWHGG........SGEP..VREFFEQI...HPMLDPGHSVVAVIADKGQKLRH..DRFK...RLQQFKAGKR..........................................................
A0A1T4R189_9ACTN/1-230              ....................MAYRHVTERADFTDLAS.GQVLRSAPGFPGFPVRLASE.LLQR.ALAHLPQ.....RP--.....VSLWDPCCGSG.YLA.TV.L.GLSHRD...R..L.S.HVRVGDVDSDA..VA.LAA.RNLELLTVEG.LAARERELRAHAEEY..GRPSF.LERARAAARLADGL....VA..LGGDLPHAV.EVAD...VFA.P...R.RP.RP..-A.........VDVVVTDVPYGDLTHWAGDr......pAGEP..VTGLLRTL...AGVL-EDHAVLVVTARTRKIALP..EGVR...PLERVRVGNR..........................................................
J7LF16_NOCAA/1-228                  ....................MSYRYATERADHSALAS.GQVLRSAPGYPGFPVRLADE.LLQR.AMVHV--.....EGDR.....VRLWDPCCGSG.YLV.TV.L.GLLHRD...L..L.T.HVRASDVSSDA..VG.IAA.RNLELLTAEG.LAERERELRRSARDF..GRVAF.VERAEAARDLAAGL....AA..MGGDLPHES.AVAD...VFS.L...T.EP.VD..--.........ADLVITDVPYGEMTHWDGE.......aPEDP..VRGLLASM...GRVL-PRNSVVVVTARTRRVRLP..EGVR...ALERVKVGNR..........................................................
A0A7S8IEC2_9CHLR/1-226              ....................MKYQYVMERENYEDLAA.GRVLISHGGATSFPVRLASE.IFQR.CAAQL-Q.....LDR-.....LRLYDPCCGSG.YLL.TI.L.GFLHGD...Q..I.K.SLHGSDVDAAA..VS.IAS.SNLGLLTQVG.LGQRRQAIAQMAHDY..GKQSH.QDALQSADMLRRQL....--..PQQAINTGA.WVAD...AAQ.-...R.TI.CQ..GC.........VDLLIADLPYGQLVTWAGT........AADP..AYALLEAQ...YLVL-GPGGLAAIISDKKQKPAH..PGYE...RLLNDTLGKR..........................................................
R9KC37_9FIRM/1-97                   ....................MEYFY-CPKDNFKDFAS.GQVLYGGGGIPNFPIRLLIE.LYCR.AKSYLPK.....SKD-.....ITIYDPCCGGG.YAL.TV.L.GFFHNH...D..I.K.KMYGSDINPNM..VS.HAK.KML-------.---------------..-----.--------------....--..---------.----...---.-...-.--.--..--.........-------------------........----..--------...-----------------------..----...----------hy........................................................
A0A1I1FU39_9FIRM/1-155              ....................MNYLY-CPAGNYEDFAS.GRVIHGAKGIPNFPVRLIAE.IFGR.AMAVSPK.....KDH-.....LVVYDPCCGGA.YSL.AI.I.GFFYGR...S..I.E.KIYGSDISEDM..IE.CAR.KNLEL-----.---------------..-----.--------------....--..---------.----...---.-...-.--.--..--.........-------------------........----..--------...-----------------------..----...----------tlsidgkempvtwednasvnelkeilplkvnmsmyggfeqvgsigqsisrddkqitte
D7AX50_NOCDD/1-231                  ....................MGYRYAVERTDHSALAG.GHVLRSAPGFPGFPVRLASE.LFQR.AMVHT--.....GGEP.....VRLWDPCCGSG.YLA.TV.L.GLLHRD...L..L.T.GVRATDVDADA..VA.LAA.RNLRLLTAEG.LAEREEELRRSARDF..GRVAF.VERAEAARDLAAGL....AA..QGGDLPHEA.AVAD...VFS.L...E.EG.VE..--.........ADLVVTDVPYGEMTRWEGNvp....ggAGEP..MRGLLASL...GRVL-PEHAVVVVTARTRRVSLP..EGVR...ALERVKVGNR..........................................................
A0A419HR07_9PSEU/1-218              ....................MAYRFAVERENHEDLAS.GSVLRSAPGLPAFPVRLATE.VFQR.ALALRG-.....LDR-.....VVLADPLCGSG.YLL.TA.L.GLLHPE...R..I.A.AVLAADVEADA..VA.VAR.QNLALLSRDG.LLARRAELVELAGRF..GKESH.RLAVAAADRLLTSL....--..-PADIPSTV.EIRD...AF-.-...-.TG.LS..GD.........ADIVLTDLPYGEQVHWRGQ........SD--..VDALLDAV...FAS--APRAVVAVVARGRKVPAR..R--R...ARESLKVGTR..........................................................
A0A343JFC4_9CLOT/1-232              ....................MQYKFEISKKDFSDFSS.GRVLYNGLNTTAFPVRLTSE.IIQR.AFHILKA.....KGANg...pYKIYDPCCGGG.FIL.TT.I.GFLYNN...L..I.S.EIIATDYDIKV..LE.IAK.KNLSLLSKEG.LNKRSKEIQGYIEAF..GKDSH.LQALESIANLESLI....--..KKEDIKIKC.MQRD...ITD.M...K.AF.PI..EK.........VNIIITDIPYGNIVDWNTN........SENP..IQKLFENS...YKALDKNHSLMVVIADKKTKLEH..KLFK...RIEYFKLGKR..........................................................
A0A223SEA5_9ACTN/1-232              ....................MTYRYATERADRSDLAT.GHVLRSAPGHPGFPVRLADE.LFQR.AASHLGS.....-DP-.....LRLWDPCCGSG.YLA.TV.L.GLLHRD...R..L.A.HILATDVDPDA..LG.IAA.RNLDLLTVDG.LAARERELRAGAAEF..GKPSF.LERADAARRLADGL....AG..LGGDLPHTV.RPGD...AFV.P...D.PP.EH..-P.........VDLVVTDVPYGDLTHWSGDvp....apGTDP..LPALLHSL...ASVL-PDHAVLAVTARARKIPLP..DGVR...ALERVRVGNR..........................................................
L0EEW0_THECK/1-237                  ....................MEYRFATDEPR-GHFAS.GRVLYNAKGAAPFPVRLADE.IVQR.CFHYLEE.....RGHSg...pYAIYDPCCGSG.YLL.TV.I.GLLHGA...Q..I.R.AVFASDIDESM..LE.TAR.RNLSLLTAEG.MRARIEQLRELYEQY..GKPSH.AEALESAAMLDGYR....-A..CGTVESIEM.FPAD...ITV.G...S.PE.AV..RDsg....fcpVNIVIADLPYGHLTGWQSG........SADP..AARMLDSL...FPLLRPGASVIALISDKSHKLRH..ERYR...RIALLKAGKR..........................................................
A0A6P1TQD5_9FIRM/1-129              ..................mh-----------------.--------------------.----.-------.....----.....-----------.---.--.-.------...-..-.-.-----------..--.---.-------ADG.LNKRMEQIKELAGLY..GKESH.EEAVQSAIRLHKRI....--..ESSNIITRV.FTAN...AFE.S...L.T-.LS..KT.........PDIIITDVPYGDIVSWEGA........DNGN..VDLLLDSL...YQIC-NNETVIGICMDKSQKNTN..EKFK...RLEKQQVGKR..........................................................
A0A853BST6_9ACTN/1-233              ....................MAYRYATERADHSDLAS.GTVLRSAPGHPGFPVRLADE.LFQR.AAARAAP.....DGRP.....VALWDPCCGSG.HLA.TT.V.GLLHRE...R..L.S.WVLATDADPAA..LG.IAR.RNLALLTAGG.LAERERGLRADAAAF..GRPAM.EERAEAAARLAARL....RA..AGGDLPAAA.RTGD...AFA.P...Q.PP.ER..-P.........VDVVLTDIPYGGLTRWRDAp.....aeGGDP..VGALLRAL...AAVL-PPEAVITVTARTRKVALP..EGVA...ALERVRVGNR..........................................................
A0A0C2G8J6_9ACTN/1-230              ....................MAYRYATERRDHSDLAS.GNVLRSAPGHPGFPVRLADE.LFQR.AAAHL--.....PAAP.....VSLWDPCCGSG.HLA.TA.V.GLLHRA...R..L.C.RLLATDTDPAA..LS.IAE.RNLALLTLSG.LAERESGLRDDAAAF..GKPAL.LERADTAARLAERL....RK..SGGDLDRTV.RAGD...AFD.P...V.AP.EH..-R.........VDLVLTDVPYGGLTAFAGAv......pAGEP..VPALMRAL...AAVV-PAHAVLAVTARTRKVPLP..EGAR...ALERIRVGNR..........................................................
A0A1M6NSQ1_9ACTN/1-229              ....................MTYRYAVDRADGSVLAS.GHVLRSAPGFPGFPVRLASE.LFQR.AAVHVGD.....TR--.....VRLWDPCCGSG.YLA.AV.L.GLLHRE...R..I.A.SVRATDVDPDA..VE.LAG.RNLRLLTAEG.LAEREEELRRSARDF..GRPAF.VERARDARALARGL....AR..DGGDLPHEA.AVAD...VFS.A...V.EP.VA..--.........ADLVVTDVPYGEMTRWSGAa......pEADP..VGGLLAAL...GRVL-PPGAVIVVAARARRIALP..EGVR...ALERVKVGVR..........................................................
A0A1H2ZGU3_9FIRM/1-225              ....................MEYRY-GKNINYEDFSS.GRVLYHISGMTNFPVRLAQE.IYGR.CIEYSRK.....KNN-.....ICLYDCCCGGG.YLV.TV.L.GFLNQN...T..I.S.RIIGSDIDLEL..LE.VAK.KNLSLLSEEG.MDNRIKEIDNMIVNY..NKESH.AMAKESAIILRSMI....--..-KTPIQYEV.FQAD...ALK.E...I.KL.EI..-K.........PDIIITDVPYDQLVDWKGS........GEGL..VNRLLDVL...YGAC-TSDTIIGLSMNKKQKVKN..DKFI...KLERQKIGKR..........................................................
A0A0H5SGT4_HERHM/1-224              ....................MEYKY-AMNCNYEDFAS.GRVLYNVSGVPNFPVRLINE.IYGR.CLGYSGK.....KEE-.....ICLYDCCCGGG.YSL.TV.L.GFLNQG...S..I.A.RIIASDIDFMM..LE.IAK.RNLSLLSEEG.IKRRISELESLYKQY..NKESH.NEAIKSAKKLLNMI....--..-QKEIEVQV.FQAN...AFE.S...I.EL.DV..K-.........PDIIITDVPYGNLVDWQGG........TG-D..VSCLLESL...KNIC-SKETVIAVSMNKVQKINT..KSFI...RLEKQNVGKR..........................................................
A0A2A2YZN3_9ACTN/1-234              ....................MPYRHATERVDSTDLAC.GVVLHSAPGYPAFPVRLAVE.IFLR.GLDHLPD.....DGP-.....VTLWDPCCGSG.YLV.TV.L.GLLQRR...S..L.R.RVIASDVDPEP..VG.LAR.KNLALLTPEG.LAARERERREQSERF..AKPSY.LEAADAARRLRERL....TA..DGGGLPCTV.ETAD...VFD.A...E.AL.AR..VVsg.....spPDLVVTDLPYGERTQWAGE.......vPGEP..VTGMLRSL...ASVL-PPHAVIAVTDRARKIPVA..P-VR...PLERLKIGTR..........................................................
A0A1I5JKD5_9ACTN/1-233              ....................MAYRYAVVRENYEDLAS.GGVLHSAPGFPAFPVRLASE.MFQR.ALAMRQD.....HA--.....AMVWDPCCGSG.YML.TV.L.GLLHPG...Q..I.T.AVVGTDIDPAA..LR.LAG.QNLALLDEAG.LSARAADLDAQAERW..DKPSY.AAAAQAARRLARRL....-P..SGQGPAPHL.HQAD...VFD.P...R.QL.RQ..ALdg.....rrPGLVITDVPYGEQTGWRGP.......gGASG..TAGMLRAL...GELL-SEDAVIAVAVRGRKLRLD..DGPR...ADATFRIGTR..........................................................
A0A3S9A2R3_9BACL/1-235              ....................MEYRYERDKENYEDYAS.GRVLYNAHGTTAFPVRLASE.IIQR.CFQVLVA.....KGSKg...pYSIYDPCCGGA.YLL.TV.V.GLLHSE...H..I.Q.SIYASDINEDV..LG.IAE.KNLSLLSAAG.IDKRKEQIQEYIKLY..NKASH.VSALESAERLSHLI....-E..GSSIENVTA.FQSD...ITA.S...D.YN.KV..MHh.......sVNIVITDLPYGDIVTWRSD........SPDP..LNNFFEHA...YDLLEGSHSVLAVIADKSQKLKH..EKFR...RIEFVKIGKR..........................................................
A0A4P6Q6L0_9ACTN/1-230              ....................MAYRYATERRDDSDLGG.GNVLYSAPGHPGFPVRLADE.LFQR.AAARLGA.....--AP.....FVLWDPCCGSG.QLA.VA.A.AMLHRD...R..L.S.RLLATDTDPAA..LS.VAE.RNVGLLSGAG.LAERERELRAQAAEF..GKPAM.VERADAAARLAERL....RG..LGGDLDGAV.RRGD...VFH.P...A.EP.ER..-P.........VDLVLTDIPYGDLTRFSGAp......pDADP..VPALVRAL...AAVL-PEHAVLAVTARTRKVALP..AGVG...ALERVRAGNR..........................................................
A0A840WS48_9ACTN/1-229              ....................MSYRYATERTDHSALAS.GQVLRSAPGYPGFPVRLASE.LLQR.AMVHA--.....EGGQ.....VRLWDPCCGSG.YLA.AV.L.GLLHRD...R..L.T.HVRATDVDADA..VG.IAA.RNLELLTAEG.LAERERELRRSALDF..GRVAF.VERAESARDLAAGL....AA..TGGDLPHES.AVAD...VFG.L...T.EP.VD..--.........ADLVITDVPYGEMTHWEGGv......pEGDP..IRGLLAAM...GRVL-PSHAVVVVTARTRRIPLP..EGVR...ALERVKVGNR..........................................................
D1BGB8_SANKS/1-223                  ....................MKFEHA-PQASYEDVGG.GQVLHSAPGFPGFPARLAVE.LFER.ARVLVGR.....ER--.....VGLWDPMCGAG.GIL.TS.V.ALLRPD...A..L.T.RVLASDVDEGA..LE.LAR.KNLLLTTVPG.LEARRAELVE-----..-RGAA.AGRVASADRLLARV....-A..GLPAPPASL.ARAD...VTD.P...S.SV.AG..LDl......dgVDVVMADLPYGTQTDWAST........STTP..TAQALEVL...RDAL-PDGAVVVLSTTEREHLR-..GLPD...ATRSFKHGHR..........................................................
A0A061PHI3_9BACL/1-230              ....................MQFLYETEAGDYRDFAS.GRVLRNAPGTTAFPVRLTSE.ILFR.CRALIGK.....KTE-.....LTIYDPCCGGA.HML.TA.A.GFLHGR...S..I.T.TIVGSDVNSSV..VP.IAK.SNVSLLTREG.LEDRKQQLQAFFDEF..QKSAH.REALESIERLEQLQ....QK..AGPFHSLQA.FDHD...ITT.S...P.PS.V-..EG.........VNIIIADLPYGNTVDWQTT........EDEP..LHQMLQNI...YETLDPDQSVVALISDKKQQTEH..RYYE...RVKALKHGKR..........................................................
A0A091CDM9_9ENTE/1-233              ....................MKFKFETLKKDYSDFSS.DKVLVNAPRTPAFPVRIASE.IMAR.CLSFLKS.....TDH-.....LTIYDPCCGGA.HLL.TV.L.GFIYST...N..L.T.KIYGTDIDKSA..LT.YAQ.KNLNLLTDET.LNQKIKTLQSVNKSQ..EEQTQsAEVLHSAKRLAALL...lDT..KAPQKEVQC.FPWD...IT-.E...G.PP.FF..KK.........VNIVITDLPYGNMAHWQGD.......iREQP..AKLLLDHI...YQTLDLNNSVVAIICNKNERIAH..QNFI...QVNRLKHGKR..........................................................
A0A2T0ML69_9ACTN/1-234              ....................MPYRHAVVRANYEDLAS.GGVLHSAPGFPAFPVRLASE.MFQS.ALALR--.....-GGG....pALVWDPCCGGG.YLL.TV.V.ALLHRR...L..V.S.GVVASDFNAEA..VH.LAE.RNLGLLTATG.LAARAAELDERAARY..DKPAY.AAAALAAGRLAQGL....SA..EGGDVRGVA.RRAD...VFD.P...D.AL.R-..-Dalg...glrPDVVLTDVPYGEQTSWLGP.......gAEGG..LGSMVRAL...GQVL-DEDAVIAVAVRGRKVPTD..GGPR...PHATYKIGTR..........................................................
A0A1B1ZMM7_9PSEU/1-185              ....................MQYRHAPAAN---HAAL.DAALASAPGRPTLPVRLTVE.LFGR.AREHVPG.....ARGT.....LTVWDPCCGAG.GTL.AV.L.GLLCA-...G..V.H.RLAGSDADPRP..LD.LAR.RNLGLLGPGG.LATRADELEELAARH..GKDAY.AGAAAAVRALVPRS....--..---RPEWSV.GVAD...AG-.-...D.PA.AV..RAalg...gavPDMVLADLPHDRQTTWSGL........----..--------...-----------------------..----...----------ppapgag...................................................
A0A7W1XUG8_9BACL/1-231              ....................MNYRYETAKKDYTDLAS.GRVLYHAPGSAPFPVRLASE.IFCR.ALALLKQ.....DQEKk...gYKIYDPCCGSG.YLL.TV.L.GFLHAG...K..I.R.EIWATDYDAEI..LE.TAA.RNLSLLTPAG.LRKREAEIREYIKKY..GKPSH.VDALASAKKLKSLQ....--..KQEPVKITC.RQRD...ITK.P...G.EN.PV..ND.........ANMIITDLPYGNLVSWQGH........EENP..INRLFENV...WQALYLDNAVVVIVTDG-QKLKH..PQFQ...RVHQLKAGKR..........................................................
A0A3A8YBF5_9BACT/1-230              ....................MVYKY-CENKNFEDLAS.GKVIAHKSGYPNFPVRLAQE.IFSR.CLHYLDN.....PGS-.....ICIYDPCCGGG.YLL.AV.L.GFLNYE...K..I.D.TIIASDINEEA..VQ.LAA.ENLSLLTKNG.LNQRIQQLKHYLSLH..NKSSH.KEALDSAANLLSIL....TN..SAHEIGYKV.FQTN...ILS.D...C.PF.DT..QTf.......kADIIFTDVPYGNLVKWQHK........NEDN..I-NLLEQL...LPVA-KDGAIVAVCSDKSQKFQS..DYFQ...RLEKQVIGKR..........................................................
A0A1I4SM55_PSUAM/1-190              ....................MQYRHAPAADR---SAL.DAVLASAPGRPTLPVRLTVE.LLGR.AREHLAS.....RGAGnp.gpVTVWDPCCGAG.VSL.TV.L.GLLCP-...G..I.A.TLAGTDADPAP..LD.LAR.RNLALLAPGG.PAARASELDDLATRH..GKESY.ADAAAAARELVPRS....RP..QWMVAPADA.HDRA...ATR.A...A.LA.G-..IA.........PDVVLADLPHGRQTSWAGA........TAAP..A-------...-----------------------..----...----------tpa.......................................................
A0A221W1A9_9PSEU/1-195              ....................MSYRFAVERTDHADLAG.GAVLRSAPGFPGFPVRLAVE.LFAR.ARAWLPD.....RSE-.....LTLWDPLCGSG.YLL.TV.L.GLLHRH...E..L.G.AVLASDVDPRA..CA.LAA.ENLGLLGEAG.LRARSAHLRDLAERF..DKPSH.AEAAEAADRLTGLL....RA..GGGDLPAVV.RRAD...ATN.P...T.ET.RA..ATag....lppVDLVITDLPYGEQTAWQGQ........AG--..--------...-----------------------..----...----------aataaa....................................................
A0A7I8DQZ9_9FIRM/1-224              ....................MNYKYA-VNQNYEDFAS.GRVFYNAKNVPNYPVRLINE.LYGR.CLSYSEK.....KED-.....LCLYDCCCGGG.YSL.TV.L.GFLNQR...S..I.S.SIVGSDIDENM..LT.TAE.KNLSLLTKEG.LARRKHELQELYLKY..SKSSH.MDAQISADRLGLFL....--..-KKDISIKI.FQAD...ALN.L...T.PQ.IF..S-.........PDIIITDIPYGHLVEWHGN........DD-C..LDKLINSL...RNFA-SNNTIIAVSMDKGQKLSQ..TGIK...RLEHQVIGKR..........................................................
A0A0N1NBN1_9ACTN/1-245              ....................MPYRHATERSDGSDFAS.GFVLHSAPNHPAFPVRLATE.LFLR.ALEHLPT.....PTGPgsgpgVTLWDPCCGSG.HLA.TV.L.GWCHRR...T..I.G.RVVASDVDGET..LS.LAR.KNLRLLSPEG.LLDRERERLELSVRF..DKPAY.AEAARAAHRLAGRL....AE..DGGALPWSA.GRAD...VFD.P...A.SL.SA..LLasaglrgaaPDVVVMDVPYGERTHWGGQ.......aPERP..VPALLRSL...AAVL-PPHAVIAVADRARKIPVA..P-LR...PLERLRIGTR..........................................................
A0A5B2XG26_9PSEU/1-235              ....................MTYRYAVDRVDRTDLAS.GSVLRSAPGFPAFPVRLASE.VFQR.AAALRGS.....AGR-.....LTVWDPCCGSG.YLL.TV.L.GLLHRD...R..I.G.AVLGSDAAEAA..LP.LAG.ANLGLLLAGG.LRARQRELAALADAH..GRPSH.LAAVAAAGRLADEV....EA..AGEDPEVVT.ATAD...VFR.P...D.RL.AE..ALag.....rsPDLVITDVPYGDQTEWSGAp......aGVEP..LPAMLTSV...ASVL-PADAVLAVACRARRVPLG..G-LP...RIGSLRVGTR..........................................................
D3EHE3_GEOS4/1-237                  ....................MEYIYESAQRSYEDFAS.GRVLYNAQGTTSFPVRLASE.IAQR.CFHILEE.....KGVQg...pYTLYDPCCGGA.YLL.TV.V.GLLHGR...R..I.R.RVIGSDINAEV..LG.IAG.KNLSLLREEG.LEQRTEQLKELLALY..HKPSH.QDALESADRLRELI....-R..MSRLEETFC.FQAD...ITQ.P...Q.PE.ES..LAsc.....kgTQIVMTDLPYGDMVSWSGG........SQEP..VEDFFNGI...HAILDPVRSVVAVISDKGQKLKH..DRFK...RIQHLKIGKR..........................................................
A0A1R1F2M5_9BACL/1-235              ....................MEYLYETKADSYEDYAS.GRVLYNAPGVTSFPVRLGSE.IVQR.CFGILED.....RGISg...pYTLYDPCCGGA.YLL.TI.T.GLLHGT...K..V.R.RMYASDVDPNA..LS.VAG.KNLALLTKQG.LTERELQLRELYGNY..GKPSH.KEALESLARLESAV....-S..GLTLDASVV.FQDN...ITE.P...H.HL.DH..VDq.......pIHLVLTDLPYGDLVSWESG........DADP..VSALFEHI...YPLLSSEGAVVAMIADKSQKLGH..ARYK...RLQHFKVGKR..........................................................
G4L5U2_TETHN/1-235                  ....................MKFKFEPIKKDYSDFSS.DKLLVNAPRTPAFPVRVASE.IMAR.SLSFLNS.....ADG-.....LTLYDPCCGGG.HLL.TV.L.GFCYSK...N..L.K.NIYGSDIDTKA..LE.YAQ.KNLNLLTPEG.LSKKKKDLQYNDEKQ..DEKTQ.LEALNSANRLEKQL...fHT..TYPKKDIQC.FHWD...ITR.K...K.PP.HL..KN.........VNIVITDLPYGKMSDWQGEg.....ttQNNP..NKQMLNNI...YQTLDLNNSIVTIICNKQEKINH..QKFE...QVKRLKHGKR..........................................................
A0A5C8JSV3_9ACTN/1-235              ....................MTYRHAIARTSHEDLAS.GAVLHSAPGYPAFPVRLASE.IFQR.ALALRGG.....DQP-.....AVLWDPCCGSG.YLL.TV.L.ALLHRR...Q..I.A.AVLACDLDPEA..RN.LAE.RNLALLSQAG.LAARAADLKARAARF..GKPAY.DSAARAACRLAAEL....DA..AGGDVPHAV.RQAD...VFD.P...A.QL.QR..TLgq.....haPDIVMTDVPYGEQTHWRGP.......sAAAG..VSGMVEAL...SAVL-PHGSVIAVTVRGRKVPMD..RGPR...PQASFKIGTR..........................................................
A0A060LXB2_9BACI/1-229              ....................MQFTYETIKRDFSDFSS.GRVLYNAPGSTGFPIRLTSE.IFQI.SRSYLQK.....PSQ-.....LNVYDPCCGGA.HLL.TG.I.GFLHGG...S..I.Q.TLYGSDSNETI..IE.TGQ.SNLRLLTYEG.LAQRKRKLEKDYLLF..NKSAH.AEALKSVDRLKSYL....DK..-TGEVKGEI.FQFN...IAS.K...D.VP.KL..EE.........IHIVMTDLPYGELVSWDTN........VLSP..VKQMLQNV...YSVL-AHDGVVAVVSDKFTLIEH..PLFR...RLKVLKHGKR..........................................................
A0A2K2FAS2_9FIRM/1-231              ....................MEYKY-CSNDNFEDFAC.GRVIYNKAGMPNFPVRLSQE.IFGR.CLSYLKN.....EKD-.....ICIYDPCCGSG.YML.TV.L.GLLNMD...S..I.N.KIIGSDIDIEA..VT.MAK.QNLSLLTEEG.MKARIQQLEDLYGRF..HKASH.EAAIQSANHIMNML....RE..HPDKPTTFV.FQAD...VLS.E...D.VL.KD..RNf.......kADIVMTDVPYGNLASWQGS........EDDI..MGMLLENL...IPVL-KPDSVVAICSDKKQKIKN..DKYQ...RLEKHQIGKR..........................................................
A0A1Y2MXF1_PSEAH/1-234              ....................MQYRHAGP---ANHAAL.DAVLVSAPGRPTLPVRLTVE.LLGR.ARSHLDG.....PGG-.....-TVWDPCCGAG.VTL.TV.L.GLLA-P...G..I.T.ALVGTDVDPGP..LD.LAR.RNLGLLRTGG.LSARAQELDALSARH..RKPAY.AEAAGCARSLVPAG....RP..AWSVGVADA.LDRD...RTR.A...M.LG.D-..LE.........PDVVLADLPHGRQTTWATPtptttpgaDGDPpgTAAFLTAV...ASVL-DARAVLVAVDRGRTVPVP..AGVR...PLERLRVGHR..........................................................
A0A852U248_9ACTN/1-230              ....................MAYRYATDRADRSDLAS.GQVLRSAPGHPGFPVRLADE.LFQR.ASAHSPN.....--RP.....VTLWDPCCGSG.YLA.AV.L.GLLHRD...R..L.A.RVLASDVDDAA..VR.LAA.RNLELLTERG.LAGREGELRARAAEF..GKPSY.LETADAARRLAARL....SG..LGGDLPHEA.WPGD...AFA.P...A.EP.GH..P-.........VDLVLTDVPYGDLTHWSGAv......pGADP..VPALLRSL...AGVL-PGPAVLAVTARTRRIAVP..DGVR...PLERLRVGNR..........................................................
A0A0M4QLW8_9PSEU/1-190              ....................MQYRHAPAAN---HAAL.DAVLASAPGRPTLPVRLTVE.LAGR.ARAHLSA.....DAP-.....LTVWDPCCGAG.VTL.TV.L.GLLEV-...G..I.T.RLVGTDADPEP..LD.LAR.RNLALLDPGG.LTARAADLDALAARH..DKPSY.ADAATAARTLVPAStpawSV..AVADARDTA.AVRG...VLA.V...A.SP.DD..TG.........PDLVLADLPHGIRTTWAAS........PTRP..--------...-----------------------..----...----------gaad......................................................
A0A5C4TI67_9BACL/11-245             ...................v-SYQFATEYENYEDLAS.GRVLYNQHGSTAFPVRLASE.LFQR.GKAILSG.....KGSRg...pYRIYDPCCGGA.YML.AS.I.GFLHGE...D..I.E.SIAASDIDPSA..VD.LAC.RNLSLLTAEG.LRKRVEQIEQMHDSY..GKQSH.AEALAGAERLRQRI...gSF..PKSAGISEC.FAAD...ATQ.P...N.ER.LK..GK........rFDIVLTDVPYGNKVEWNTE........ASDP..AGLLLDRL...EPVL-APASVVILVSAKDFKITH..VRYR...RLGQYKIGKR..........................................................
A0A7R7ICH8_9FIRM/1-226              ....................MEYKF-TPNDNYEDFAS.GRVLYHVGGAPTFPVRLTLE.IYER.CLQYSNK.....KTD-.....ISLYDCCCGGA.YML.TI.L.GLLKGN...T..I.S.RLYGSDIDSGS..IK.LAK.DNLSLLTTTG.IQKRRDELTTLYDTY..KKDSH.SQALQSIDRIEKLL....--..-SKEINTSI.FHQN...ILE.L...S.DL.PF..I-.........PDIIITDVPYGNLVEWGDG........NS-D..INQMMDAI...SKVC-SPETIICVCMDKKQKIQTdtDIYQ...RLEKQSIGKR..........................................................
#=GC seq_cons                       ....................MpY+atsp+psapDhAS.GpVLhsAPGhPuFPVRLAoE.lapR.uhshltp.....pss......lslaDPCCGuG.YLL.TV.L.GLLHtc...p..l.s.plhuSDlDsps..lp.lAt.+NLuLLotpG.LspRtpcLcphstpa..uKsoa.h-AhpuAcRLtstl.....t..tssslstps.hpuD...shs.s...t.t..sh.............sDlVlTDlPYGphspWpGs........sssP..lsthLpsl...ttlL.sspuVlulssct+ph.h...tthc...tlcph+lGpR..........................................................
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