#=GF ID AvrLm4-7
#=GF AC PF18661.5
#=GF DE Avirulence Effector AvrLm4-7
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08376
#=GF GA 25.00 25.00;
#=GF TC 26.80 28.00;
#=GF NC 23.20 22.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 26082394
#=GF RT Crystal structure of the effector AvrLm4-7 of Leptosphaeria
#=GF RT maculans reveals insights into its translocation into plant
#=GF RT cells and recognition by resistance proteins.
#=GF RA Blondeau K, Blaise F, Graille M, Kale SD, Linglin J, Ollivier B,
#=GF RA Labarde A, Lazar N, Daverdin G, Balesdent MH, Choi DH, Tyler BM,
#=GF RA Rouxel T, van Tilbeurgh H, Fudal I;
#=GF RL Plant J. 2015;83:610-624.
#=GF DR INTERPRO; IPR040621;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC AvrLm4-7 is found in Leptosphaeria maculans, an ascomycete
#=GF CC fungus in the dothideomycete group which is responsible for stem
#=GF CC canker (blackleg) of Brassica napus (oilseed rape, OSR) and
#=GF CC other crucifers. AvrLm4-7 is one of six avirulence genes which
#=GF CC encodes a small secreted protein strongly over-expressed at the
#=GF CC onset of plant infection. This gene confers a dual recognition
#=GF CC specificity by two distinct resistance genes of OSR, Rlm4 and
#=GF CC Rlm7 and loss of AvrLm4 avirulence was demonstrated to be
#=GF CC associated with a strong fitness cost. Structure and functional
#=GF CC analysis of AvrLm4-7 protein show that it contains the motifs
#=GF CC RAWG and RYRE, part of a well-structured protein region held
#=GF CC together by disulfide bridges. Mutations in the RAWG motif or in
#=GF CC the RYRE motif (especially mutations in both motifs) almost
#=GF CC abolished the translocation of AvrLm4-7 into cells. Furthermore,
#=GF CC loss of recognition of AvrLm4-7 by Rlm4 is caused by the
#=GF CC mutation of a single glycine to an arginine residue located in a
#=GF CC loop of the protein [1].
#=GF SQ 41
#=GS N4V506_COLOR/23-113 AC N4V506.1
#=GS E3RP90_PYRTT/1-77 AC E3RP90.1
#=GS B2W4X8_PYRTR/20-109 AC B2W4X8.1
#=GS A0A364N3D7_9PLEO/22-108 AC A0A364N3D7.1
#=GS A0A8H4N2T4_9PEZI/23-118 AC A0A8H4N2T4.1
#=GS A0A2P5HGA0_9PEZI/20-108 AC A0A2P5HGA0.1
#=GS K2REL9_MACPH/23-118 AC K2REL9.1
#=GS A0A7J6JKX1_COLFN/24-112 AC A0A7J6JKX1.1
#=GS A0A2T2NDD9_CORCC/5-90 AC A0A2T2NDD9.1
#=GS E3RP91_PYRTT/23-119 AC E3RP91.1
#=GS A0A8H4N713_9PEZI/20-109 AC A0A8H4N713.1
#=GS B2W4X7_PYRTR/23-119 AC B2W4X7.1
#=GS E3RDK4_PYRTT/20-109 AC E3RDK4.1
#=GS A0A8H4IYJ8_9PEZI/20-105 AC A0A8H4IYJ8.1
#=GS K2S3P9_MACPH/18-110 AC K2S3P9.1
#=GS T0K8V7_COLGC/24-112 AC T0K8V7.1
#=GS A0A4R8QL51_COLTR/26-119 AC A0A4R8QL51.1
#=GS K2SJ40_MACPH/23-108 AC K2SJ40.1
#=GS E4ZIG0_LEPMJ/23-125 AC E4ZIG0.1
#=GS A0A2T2NCS5_CORCC/23-118 AC A0A2T2NCS5.1
#=GS K2RA67_MACPH/22-107 AC K2RA67.1
#=GS A0A2T2N3T1_CORCC/22-83 AC A0A2T2N3T1.1
#=GS A0A4R8RLB0_COLTR/23-111 AC A0A4R8RLB0.1
#=GS K2RME6_MACPH/20-109 AC K2RME6.1
#=GS A0A2T2NCU5_CORCC/20-109 AC A0A2T2NCU5.1
#=GS A0A2T2N2T0_CORCC/20-109 AC A0A2T2N2T0.1
#=GS E4ZN67_LEPMJ/22-76 AC E4ZN67.1
#=GS A0A4T0WI10_9PEZI/24-110 AC A0A4T0WI10.1
#=GS K2S6B3_MACPH/23-122 AC K2S6B3.1
#=GS E4ZN68_LEPMJ/20-109 AC E4ZN68.1
#=GS E4ZIG1_LEPMJ/22-107 AC E4ZIG1.1
#=GS E4ZIG2_LEPMJ/20-111 AC E4ZIG2.1
#=GS K2T0N7_MACPH/20-110 AC K2T0N7.1
#=GS A0A8H4IYX3_9PEZI/20-109 AC A0A8H4IYX3.1
#=GS K2S6K5_MACPH/20-106 AC K2S6K5.1
#=GS A0A0G2FUN8_9PEZI/20-106 AC A0A0G2FUN8.1
#=GS A0A2T2N2L6_CORCC/23-118 AC A0A2T2N2L6.1
#=GS A0A364N3H3_9PLEO/20-109 AC A0A364N3H3.1
#=GS N4UP70_COLOR/26-119 AC N4UP70.1
#=GS A0A364N376_9PLEO/23-116 AC A0A364N376.1
#=GS E5A6Z5_LEPMJ/22-113 AC E5A6Z5.1
N4V506_COLOR/23-113 ...............CRQAIVTYSK..QYD-CGLNNf...vTAVDDDCK.KLADNIGTQGRK.F.AEI..PTVD----SS.eCLECDND....GEfrR....CR......CMLTAWRFRDWEPE....PAK----yeefqyeyw....
E3RP90_PYRTT/1-77 ..............m----------..---ACDASP.....APMNEECY.KIMTNMRDYSNS.H.SRL..WGGDFTRDVPvaCGTCDSE....GK.vT....CI......CTVRAWRFREWMYD....PGFRYW-p............
B2W4X8_PYRTR/20-109 ...............CTQWQIFYRT..KSYACELDA.....GAHRNLCN.QMPGKYLIYNAD.N.QGR..LGTDITASTF..CDPCSQR....GQ..R....CY......CLVQFWRYSEWISSyippFEDNTW-r............
A0A364N3D7_9PLEO/22-108 ...............CVQRYVEYSR..EKP-CSLGN.....DVIDQECR.TIARDLRNYGIS.H.GKI..YGGDVDGKVD..CRACDGT...pSI.nY....CS......CTVTAWRFREWMHE....PPLSQR-p............
A0A8H4N2T4_9PEZI/23-118 ...............CKQRYYIYYK..EYANCNEGLepaikERAARECS.TFRQPFVELSDQ.T.HNQ..LGRDITAELViaAGTLPDN....SA..N....CIf...yqCNVVAWRYREWQTD....MEHRAL-p............
A0A2P5HGA0_9PEZI/20-108 ...............CTRSSITFVS..PEPVLTLDD....qTKFGAACT.VLKTTMAEFSAT.N.DNI..YGPDLTNRFI.cCNSAGNT....SA.pM....CH......CSVTAWRFHEWQTT....ENKY---dlg..........
K2REL9_MACPH/23-118 ...............CKQRYYIYYK..EYANCNEGLqpaikERAARECA.TFRQPFVELSDQ.T.HNQ..LGRDITAELViaGGTLPDD....SA..N....CIf...yqCNVVAWRYREWQTD....MEHRSL-p............
A0A7J6JKX1_COLFN/24-112 ...............CRQAIVTYST..EYE-CDLDHf...dTAIAEDCK.KLAEGIGKQGKK.F.---..AEPPVVDSVE..CLECDPDg..eSR..K....CR......CLLSAWRFRDWEPE....P------akfddfqye....
A0A2T2NDD9_CORCC/5-90 ...............CRQKFIEWQT..AQP-CGTQK.....AVMDADCW.KIEAAMKDYSLA.H.SRV..WGASFTADNV..CFPCDST....GQ.vL....CT......CTVRAWRYREWMYE....PGSASWP.............
E3RP91_PYRTT/23-119 ...............CYQRFYTYYK..EYQNCHEALswglePHLAKECA.TLGQKFKDLNAQ.P.VMQqiFGRDITSGLD.gTVKLGNE....SP..N....CIa...wrCGVTAWRFREWQNN....LENTPL-p............
A0A8H4N713_9PEZI/20-109 ...............CTRHTIQFKS..AKATCTDGA.....APFNTGCG.AIRETIKTFSAN.N.ENI..YGQALTSQFT.gCDSCTAV....DP..R....CY......CTVTAWRFREWQTT....SN-----tfdlgdwe.....
B2W4X7_PYRTR/23-119 ...............CYQRLYVFYK..EYQNCHEAQawgldQKLKLECA.ALGQKFKDLNAK.P.EMQqiFGRDITADMA.eTITLPDD....NP..N....CIa...qqCVVTAWRYREWQTN....MENKAL-p............
E3RDK4_PYRTT/20-109 ...............CTQWQIQFKS..KSNGCELDA.....GLFRNLCN.EMPAKYLIYNEQ.N.KGR..LGVHITASTF..CDPCGQQ....SP..R....CY......CLVQFWRYSEWISNyipaLPHDTW-e............
A0A8H4IYJ8_9PEZI/20-105 ...............CTQKYMEWYK..YYP-CKTQK.....TVIDGDCW.KIQSNMRDYSLS.H.EKV..WGGSFTADNV..CNSCEDG....GQ.mW....CT......CTIRAWRFREWMYE....PGSSSWP.............
K2S3P9_MACPH/18-110 ...............CQQFLATLQT..TEYACKGYN....dAGLQAKCE.ALVPWYEQYSKN.N.QNR..LGQGAQYESY.wCDNCNDEn.klNP..K....CY......CGIRFWRLREWMGR....VPD----pptdsk.......
T0K8V7_COLGC/24-112 ...............CRQAIVTYST..EYE-CDLDHf...dTAIAEDCK.KLAEGIGKQGKK.F.---..AEPPVVDSVE..CLECDPDg..eSR..K....CR......CLLSAWRFRDWEPE....P------akfddfqye....
A0A4R8QL51_COLTR/26-119 ...............CMQAVVKYRR..NWT-CATTQ.....AEIDKSCA.GIVQTITVHASRaNcKQK..FGGCEVANPA..AFVKEDQ....KW..N....CRqyktsfCTFTAWRFRYWVGE....PQK----vvdwe........
K2SJ40_MACPH/23-108 ...............CRQKYIEWYK..YAP-CKAKK.....SDIDGECW.EIQRKMRDYSNA.N.QKI..WGGQFTADNI..CQSCESD....GQ.mW....CT......CTVRAWRFREWMVD....PGSWKWP.............
E4ZIG0_LEPMJ/23-125 ...............CKKRYFRYTN..SWRNCNEGRadflkERLKEDCEvNMTQTYLQHNSR.V.NGA..LGAEISGELE..RTYSPPD....VE..S....CIt...yrCTITAWRFREWQNN...dF------ddkgkilfnttsw
A0A2T2NCS5_CORCC/23-118 ...............CKQKWFIYQK..EYQNCNEGVrpevhYRTVDECL.TFHNAFLELSAQ.T.QNQ..FGRDITSEMQsaAAPLPPN....NP..N....CIy...yrCRVISWRYREWQTN....MDNRPL-p............
K2RA67_MACPH/22-107 ...............CTQKYMEWYK..YYP-CKTQK.....SVIDGDCW.KIQGNMRAYSLS.H.EKV..WGGAFTADNV..CNSCEDS....GE.mW....CT......CTVRAWRFREWMYE....PGSSEWP.............
A0A2T2N3T1_CORCC/22-83 ...............CRQRYIEWYK..YMP-CGGNK.....GPLDGECW.QIEKNMRDYSLS.H.EKV..WGGSFTADNW..M------....--..-....--......--------------....-------qepgssywp....
A0A4R8RLB0_COLTR/23-111 ...............CRQAIVTYSK..QYD-CGLNNf...vTAVDDDCK.KLADSIGTQGRK.F.AEI..----PTVDSI.eCLECDND....GEfrR....CR......CMLTAWRFRDWEPE....PAKY---qefqye.......
K2RME6_MACPH/20-109 ...............CQQWKVGFIS..KAEACELDA.....GHWRNTCL.DLTYDYIEYSRA.N.GAR..LGHDISGTTS..CDTCDTK....NP..K....CY......CHIAFWRYREWMGTtipyLEN----diws.........
A0A2T2NCU5_CORCC/20-109 ...............CTQWKAGFVS..KQSACELDT.....GYWGNTCR.DLTYKYIDYSNK.N.QAR..LGRDITSQLY..CDPCGAV....EA..R....CY......CRLHFWRIREWMGW....-------slphiedndwa..
A0A2T2N2T0_CORCC/20-109 ...............CQQWKVGYAS..KGTACELDA.....GYWRNKCR.DMSWKYIDYSRK.N.QER..LGRDIGGDAY..CDPCTNN....DP..K....CY......CRVTFWRYKEWMGQtipyF------edadwa.......
E4ZN67_LEPMJ/22-76 ...............CRQKRIQWYK..MAE-CHNGK.....GQVDRDCW.QIEANMRAYSDQ.N.EGV..YGPVISADS-..-------....--..-....--......--------------....-------ewml.........
A0A4T0WI10_9PEZI/24-110 ...............CRQAIATYSK..HYE-CNLKKf...eSAITQDCQ.KLAASIGKAGPK.F.A--..--EPPTVDSV.eCLECDAD....GEarK....CR......CLLTSWRFRDWEAE....PA-----kfqdfe.......
K2S6B3_MACPH/23-122 ...............CKKRYYQYWM..EFANCNEGLqptikERAARECA.TFRQPFVDLSAQ.T.QNQ..LGRDITAELTiaGGTIDEYtdkgNT..N....CIy...yqCTVTAWRYREWQTN....MEHRAL-p............
E4ZN68_LEPMJ/20-109 ...............CSQYRIDYAA..NNQTCEKDA.....GKWRNLCS.DLAYQYLQWTKV.N.GGR..LGHDIRPVTY..CNTCDMQ....DP..R....CY......CSVSFMRLREWMGTtiptI------pdpnwh.......
E4ZIG1_LEPMJ/22-107 ...............CRQKRIEFIK..AKP-CAEDY.....ELIEKQCL.NITTELRKYGES.I.GRV..YGSTIEYTPA..CQDCQGA....NT.tS....CS......CTITAWRFREWMHE....PPIDRR-p............
E4ZIG2_LEPMJ/20-111 ...............CTQYGIGYASraNETACETSA.....PKYLNYCR.DLAFEYNEYSLK.N.MVR..LGGTIAAHTN..CDPCNHP....QP..R....CY......CEVGFWRYKEWLGT...dV------pklnhthlv....
K2T0N7_MACPH/20-110 ...............CQQWKIGFVS..RERACEVDG....aGRLRNVCG.DLAYRYIQYSLA.N.GVR..LGRDITGTTS..CDPCDDP....NP..K....CY......CRITFWRFREWMGT....-------qvpylsdnnwl..
A0A8H4IYX3_9PEZI/20-109 ...............CQQWKVGFVT..KENACELDA.....GHWRNACL.DLTYDYIEYSRS.N.GAR..LGHDITGTTS..CDTCDTK....NP..K....CY......CRITFWRYREWMGT....-------tipylenavws..
K2S6K5_MACPH/20-106 ...............CTRHTIQFKS..AKATCTDGA.....AEFQKACP.TIRETVKSFSSA.N.ENI..YGQDFTSQFT.gCDSCTAT....DP..R....CY......CTVTAWRFHEWQTT....TNT----fdlg.........
A0A0G2FUN8_9PEZI/20-106 ...............CTRYTVKFRS..AAPTCVDDQ.....AAFNTHCT.EIKDTIADFSDD.N.EDL..YGSDFTSQFT.gCDSCSVA....DP..R....CH......CSVTAWRFHEWQST....ENEY---dtg..........
A0A2T2N2L6_CORCC/23-118 ...............CKQRFYNYQK..EFANCNEGLmpgvkGRAERECA.SFRQAFVDLSAQ.A.NSQ..LGHSITSELKlvGEVLPDD....NP..N....CIy...yqCQVVAWRYREWQTE....MNHRAL-p............
A0A364N3H3_9PLEO/20-109 ...............CTQYKIGYKS..KSTACELDG.....NTWRNHCR.DLLFQYTQYTEQ.H.DGR..LGKDMTQDVS..CDPCDWK....NQ..H....CY......CTVSFWRFREWLGTeiptMKHDSW-v............
N4UP70_COLOR/26-119 ...............CIQAVVKYRR..NWT-CATTQ.....TEIDKSCA.GIVQTITVHASRaNcKQK..FGGCEVANPA..AFVKEDQ....KW..N....CRqyktsfCTFTAWRFRYWVGE....PQK----vvdwe........
A0A364N376_9PLEO/23-116 ...............CKQRFFSYQT..AYENCNEGLaigvkARFEKECA.TFAQKYQSYNNE.V.NGA..IGRDIDSKVN..SWTSGDN....ES..S....CIr...yeCQVRAWRFREWQPE....FDDKPI-p............
E5A6Z5_LEPMJ/22-113 creasisgeirypqg----------..---TCPTKT.....EA-LNDCN.KVTKGLIDFSQS.H.QRA..WGIDMTAKVQ..CAPCITT....DP..WdvvlCT......CKITAHRYREFVPK....IPY----ssfss........
#=GC seq_cons ...............CpQthlpahp..phssCptst.....sthppcCt.sltpshtpaopp.s.pth..hGtslTupsh..CssCsss....s...p....Ch......CplsAWRaREW.sp.....t.....s............
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