#=GF ID   AvrM-A
#=GF AC   PF18241.5
#=GF DE   Flax-rust effector AvrM-A 
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF03287
#=GF GA   27.00 27.00;
#=GF TC   29.50 107.40;
#=GF NC   25.10 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   24101475
#=GF RT   Structures of the flax-rust effector AvrM reveal insights into
#=GF RT   the molecular basis of plant-cell entry and effector-triggered
#=GF RT   immunity.
#=GF RA   Ve T, Williams SJ, Catanzariti AM, Rafiqi M, Rahman M, Ellis JG,
#=GF RA   Hardham AR, Jones DA, Anderson PA, Dodds PN, Kobe B;
#=GF RL   Proc Natl Acad Sci U S A. 2013;110:17594-17599.
#=GF DR   INTERPRO; IPR040489;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in AvrM-A present in Melampsora lini.
#=GF CC   AvrM-A is a natural variant of AvrM which is a secreted effector
#=GF CC   protein that can internalize into plant cells in the absence of
#=GF CC   the pathogen and bind to phosphoinositides. AvrM results in
#=GF CC   effector-triggered immunity. This domain makes up part of the
#=GF CC   C-terminal region, which is highly conserved in AvrM. The domain
#=GF CC   is required for M-dependent effector-triggered immunity [1].
#=GF SQ   8
#=GS F4S8Q3_MELLP/381-526  AC F4S8Q3.1
#=GS F4S8Q4_MELLP/250-399  AC F4S8Q4.1
#=GS F4RW28_MELLP/278-425  AC F4RW28.1
#=GS F4R586_MELLP/376-521  AC F4R586.1
#=GS F4S6E1_MELLP/328-477  AC F4S6E1.1
#=GS F4RGY5_MELLP/399-544  AC F4RGY5.1
#=GS F4S6E2_MELLP/233-380  AC F4S6E2.1
#=GS F4RW29_MELLP/280-429  AC F4RW29.1
F4S8Q3_MELLP/381-526             ......ESLAPGALAKLTDAEYVRKAAFFDETVAQNLDDWMFYEKQAAQKFNELYPKVLERF..KKIKGEEKFNGR.MRSIIKKLDPHATAE.STDPEVI....KQ....A...eRQFVKEAKAL--KDPEIKKAAFAIKSWEKTTRNAKNNAIRSADKIFKRNKILES....
F4S8Q4_MELLP/250-399             ....gl--LTPEALSKLSNTQYIKQAAASDKKVLQNYNKWMSAEEYLRDLRSRWFGEAKTTF..IKSNGDALFDER.MGAITQILKGSKGRGgSTDSESTi.elAA....Q....KEFIKEQAKN-LKDEGLQRAVLAIKLAEQSAAKAESAALRSADQFFKRNKLLES....
F4RW28_MELLP/278-425             ftsgei--------LKLTDKQYVRKAALYDKDTNKNHGQWLKNEKSLRELVKSTRSKLSPTF..IR-DGEQILKSK.IDETYSKLIKELKLK.GKEIDEI....SI....QdlaeREIIKKEAKGSEYQEFHHVGIREIERLEKITEKFKRLALRSADKFYKGLGVLKS....
F4R586_MELLP/376-521             ......KSLNPQALAQLTDKQYVEQAAFYDIKAYRRYAQWSDAEKRL---DDILYDQDLVAA..LKSKFETATKDKeINVIADQLKDNLKAK.GKPIDEK....TVntvaR....SNFIKEQASL---DPVLQHYVSRIKIAEKQIENTKNTALEGADRYYKSHKLLKS....
F4S6E1_MELLP/328-477             ......DSLTPEALSKLTPKEYVKKASFFDKEVYKKYVQWKTEERLMRVAVNTFFPKVAKKF..KTGQCEKEFDEE.WANTIKGLQADVKFR.GGPSDLE....TI...eQa.skRQFIKKQANHYPNDIKLKQPEDKIQLFEKNIENLMKDALRGANIVFKRD-----pvsr
F4RGY5_MELLP/399-544             .....d-TLEPQAFTQLTDKQYVEKAAFYDIKAYQRYAQWSDAEKRL---DDVLYDQELVAT..LERKFETATQDKeINKIADQLKEDLKAK.GKPIDGK....TVhavaR....SKFIKKQASL---DPFLRQYVSRIKSTEKQVENTKNAALRGADRYYKSHKLLKS....
F4S6E2_MELLP/233-380             ......ESLTPEALSKLTNKEYVKKASLFDQKVQQNLAEWEAQEDLMHDYLSKFFKLQALEF..KS---QKKLDAK.WTKAMEEVKEKAKET.GEPTDPTslekAA....Q....RQFIKNQAKRHPKNLGWKEDEETMKEFEKYVREAEKKALRSAKRVLPRTDLLRS....
F4RW29_MELLP/280-429             ......ESLSPQALSKLTDEDYARKAALFDKDVNRKYGQWLNIEETLDRLVKDSLSRLSFVFshSRKEGDAILKKK.IDFISSKMIEKAKRK.GKPIEEK....II....QkaaeKEVIKREAKNYLVFEEA---LVNLKYLEKSGMKAKSEALRSADKFYKNNRILKS....
#=GC seq_cons                    ......cSLsPpALoKLTDKpYV+KAAhaDccVhppYuQWhstE+pLcphssphaschthsF..h+tcsEpthccK.hspIhcpLccchKt+.GcPhDtp....sl....Q....+pFIKcQApt..hD.tl+pslppIKhhEKpscpsKssALRSAD+aaKps+lL+S....
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