#=GF ID   AvrPtoB-E3_ubiq
#=GF AC   PF09046.14
#=GF DE   AvrPtoB E3 ubiquitin ligase
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_2fd4
#=GF GA   25.00 25.00;
#=GF TC   27.60 100.00;
#=GF NC   21.00 18.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16373536
#=GF RT   A bacterial inhibitor of host programmed cell death defenses is
#=GF RT   an E3 ubiquitin ligase. 
#=GF RA   Janjusevic R, Abramovitch RB, Martin GB, Stebbins CE; 
#=GF RL   Science. 2006;311:222-226.
#=GF DR   INTERPRO; IPR015133;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The E3 ubiquitin ligase domain found in the bacterial protein
#=GF CC   AvrPtoB inhibits immunity-associated programmed cell death (PCD)
#=GF CC   when translocated into plant cells, probably by recruiting E2
#=GF CC   enzymes and transferring ubiquitin molecules to cellular
#=GF CC   proteins involved in regulation of PCD and targeting them for
#=GF CC   degradation. The structure of this domain reveals a globular
#=GF CC   fold centred on a four-stranded beta-sheet that packs against
#=GF CC   two helices on one face and has three very extended loops
#=GF CC   connecting the elements of secondary structure, with remarkable
#=GF CC   homology to the RING-finger and U-box families of proteins
#=GF CC   involved in ubiquitin ligase complexes in eukaryotes [1].
#=GF SQ   2
#=GS A0A3D8JU15_9BURK/428-562  AC A0A3D8JU15.1
#=GS HPAB2_PSESM/428-553       AC Q8RSY1.1
A0A3D8JU15_9BURK/428-562             gd--VMTDLRTQLDayeAVNAKFSGLRPISRAYAE-EHMQFKDAAIYNQDDegpfskdlATACMFGEDLSLSNPNQRVIGLATVRSSREQAFDPDVNKEIVFMDMNKLAEFLVNNPKHPHNNQPLNVNNIADYAFKI--s
HPAB2_PSESM/428-553                  ..PAVVANIRAALD...PIASQFSQLRTISKADAESEELGFKDAADHHTDD........VTHCLFGGELSLSNPDQQVIGLAGNPTDTSQPYSQEGNKDLAFMDMKKLAQFLAGKPEHPMTRETLNAENIAKYAFRIVP.
#=GC seq_cons                        ....VhsslRstLD...slsupFStLRsIS+A.AE.EchtFKDAA.appDD........sTtChFGt-LSLSNPsQpVIGLAss.osppQsas.-sNK-lsFMDMpKLApFLsspPcHPhsppsLNspNIAcYAF+I...
//