#=GF ID   BLI1
#=GF AC   PF17324.6
#=GF DE   BLOC-1 interactor 1
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD073250
#=GF GA   26.90 26.90;
#=GF TC   27.90 32.70;
#=GF NC   25.00 24.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   23547030
#=GF RT   The BLOC-1 complex promotes endosomal maturation by recruiting
#=GF RT   the Rab5 GTPase-activating protein Msb3.
#=GF RA   John Peter AT, Lachmann J, Rana M, Bunge M, Cabrera M, Ungermann
#=GF RA   C;
#=GF RL   J Cell Biol. 2013;201:97-111.
#=GF DR   INTERPRO; IPR020491;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   In yeast BLOC-1 consists of six subunits localised to the
#=GF CC   endosomes. In the absence of BLOC-1 subunits, the balance
#=GF CC   between recycling and degradation of selected cargoes is
#=GF CC   impaired. This family contains BLI1 (BlOC-1 interactor 1)
#=GF CC   protein, a subunit of the BLOC-1 complex which mediates
#=GF CC   endosomal maturation [1].
#=GF SQ   26
#=GS G0W7G6_NAUDC/10-106      AC G0W7G6.1
#=GS A0A1S7HZT7_9SACH/1-111   AC A0A1S7HZT7.1
#=GS A0A0C7MZ07_9SACH/1-108   AC A0A0C7MZ07.1
#=GS A0A1X7QWE1_9SACH/8-115   AC A0A1X7QWE1.1
#=GS A0A4C2E4T8_9SACH/1-111   AC A0A4C2E4T8.1
#=GS BLI1_LACTC/5-113         AC C5DGT3.1
#=GS G8ZQ95_TORDC/1-111       AC G8ZQ95.1
#=GS BLI1_VANPO/1-111         AC A7TLL0.1
#=GS A0A1G4JVM3_9SACH/1-108   AC A0A1G4JVM3.1
#=GS J8PZS1_SACAR/1-110       AC J8PZS1.1
#=GS H2B003_KAZAF/1-107       AC H2B003.1
#=GS G0VJC9_NAUCC/7-117       AC G0VJC9.1
#=GS BLI1_CANGA/1-103         AC Q6FLQ1.1
#=GS A0A7H9B7H9_ZYGMR/24-134  AC A0A7H9B7H9.1
#=GS A0A1S7HQP2_9SACH/1-111   AC A0A1S7HQP2.1
#=GS I2H839_TETBL/1-108       AC I2H839.1
#=GS A0A1G4MKZ9_LACFM/1-108   AC A0A1G4MKZ9.1
#=GS BLI1_ASHGO/1-108         AC Q75DG4.1
#=GS J8TYM2_SACK1/1-110       AC J8TYM2.1
#=GS G8BXX4_TETPH/1-111       AC G8BXX4.1
#=GS G8JS86_ERECY/1-107       AC G8JS86.1
#=GS A0A1G4J6F1_9SACH/1-110   AC A0A1G4J6F1.1
#=GS J7RFQ3_KAZNA/90-165      AC J7RFQ3.1
#=GS A0A7H9HSU3_9SACH/1-111   AC A0A7H9HSU3.1
#=GS BLI1_YEAST/1-110         AC P35727.1
#=GS BLI1_KLULA/1-103         AC Q6CP44.1
G0W7G6_NAUDC/10-106                 ...........sgg---KNKFLQTKVEACVNSLQELLDTEAARSISTFAGKTGSNKVWLEELSAEYK.LKPDRKLDA..IGELYAQQLKQLDDLEEKS------------------------------fimkiyvmklksfkkn
A0A1S7HZT7_9SACH/1-111              ..............MREQESTLHQDVEHCVEALQDYLNTELAKAVSVFSKKAGENETWLEEIRTKFQ.LKDEDELQA..IKTLKEQSLTRLEVLEKKVDYYEELCDELEEFQNELEVKTKLEQNRRSR................
A0A0C7MZ07_9SACH/1-108              ............mk----ETQIRKYVEHCNNSLQEIVDLQSAQAIKEFQTKTEENFQRLDDAKSRFK.T-DTQSIEE..FKALKSEFSTKIDDLEKSIDYYEKLADEIQEFLVECEVKEKLAMKRLS-q...............
A0A1X7QWE1_9SACH/8-115              .............e-RANRRQLQRDIETCVHVLQEGVDTEAAEAISVFSNKTTSNEKWATTLAGTYQ.IKTDEEFKS..FETDKRLYIEKIDKLEEEVEYFEKLCIEMEEFSKELEVKTKVERSR---................
A0A4C2E4T8_9SACH/1-111              ..............MRDQERTLNQDVEHCISVLQDYLDTGSAKAISVFDKKTSENEDWLEEIRLKYR.IKSDDELQT..IKMLKQQRLIQLEALEGKVDYYEKLCDELEEFQDEMEVKAKLEQSRRSR................
BLI1_LACTC/5-113                    ...........agm---KERVLRQHIEGCIDQVQEYVDLESAQAISSFESKAVDHFRCLDGLKAQYN.TRE-DKISE..FKRLQSEYATKVDGLEKSIEHFEKLSEEIEEFLVELEVKTKLASKRQS-................
G8ZQ95_TORDC/1-111                  ..............MREHERVLHQDIERCVEILQESVDAEAAKAISVFSKKTSDNEEWLKDLKTKFK.LKDKVELEQ..LLSLKNKQLDQIEGIEKKIDYYERLCDELEEFQDEIEVKMKLEQSRRSR................
BLI1_VANPO/1-111                    ..............MREQERKLSNGIEHCLSKTQEYVDMESAKAISIFSSKVNSNGRWLAEISGKYE.LKESGELEA..FRLLKEDHVKMLDQLEGKIEYYEKLLDELTEFTSEIEIKRKIEKNRRSR................
A0A1G4JVM3_9SACH/1-108              ............mk----EGQLKRQVESCTNQLQGNVDLQSAQAITTFQMKSEDNFRRLDDLKDKFQ.TN-YQAIED..YKLVKTQFRTKIEDFEKSLEYHEKLADEIEEFLAESNVKKKVAIKRQSR................
J8PZS1_SACAR/1-110                  ............mg---EQSKLYYDVEKLVNSLQESFDLDCAQSVSLFTSKSRSNETWLEDLENKFK.LKDDLELDN..VENLKTEIDAKLDVLEDKVSYYEKLCKELEEFQNEMKIKTVVNNRRQS-q...............
H2B003_KAZAF/1-107                  .............m------KLNQDINNYINELQTYIDTESVKTISLFNKKSQETEEWLNRLSSEFEnLKDEEELTK..LKELHESYEQNLDELESKIEYLEKLCDEIDEVYDELGVKTKVNDRRKSR................
G0VJC9_NAUCC/7-117                  .............g-TNNARSMQQNVENCMKQVQEFVDTETTKSISLFSAKTRANEVWLQEITEKYS.TIPDDELKK..LDALKKDYLEKLGELTKKVEYFEQMCDELEEFQNELEIKTKVNTNRQSR................
BLI1_CANGA/1-103                    .............m-------IKQDVQKCVDALQDFVDKEIGESVNLFSCKSRANNELLLNIDEKFQ.LKDKDELHQ..LGEQKIENQNKLQEIRNKVEYYEKLLTELEEAQKELEVRYKLVS-----ksk.............
A0A7H9B7H9_ZYGMR/24-134             ..............MKEPERSLRQDIEHCVDILQDVIDTESTKSISIFSKKTNENERWLEQLKPSFQ.LKNDQDLQK..FQELKNAQTKKLNDIEQKIDYYERLFAELEEIQNELEVKAKLEKKRRSR................
A0A1S7HQP2_9SACH/1-111              ..............MREQERTLHQDVEHCVEALQDYLNTELAKAVSVFSKKADENETWLEEIRAKFQ.LKDEDELQT..IKTLREQSLTRLEVLENKVDYYEKLCDELEEFQNELEVKTKLEQNRRSR................
I2H839_TETBL/1-108                  .............m-GDKYRSMNQDIDLLIQAIQDKVNVDSAKSMSTFEEKSSKKVQMLKDLTNKYN.LLNQAKLNN..ISEIKTIQLKQLDEIENKLTYLEKLCDEFDEFQNELAIKKS--------tksss...........
A0A1G4MKZ9_LACFM/1-108              .............m---KEKVLKQEIERCAEHVQEIVDLESAKAISEFQSKADENYQWLEELKTRYS.MRNDNE-ND..IRQLRSRHKEKIDALEEDVNYFEKLLDEMEEFVTELDVKRKLANKRQSR................
BLI1_ASHGO/1-108                    .............m---NEKQLRQQLDRCLDHVQEHVDMLSARAISKLSGDAVANHEWLSELSGRYP.TRSAEELQQ..FRELKDGYVKKLDTLETEVKYLEDLGQELAEFQNELSVKLQ--------rirrnsy.........
J8TYM2_SACK1/1-110                  ............mg---EQNNLCYDVEKLVNSLQEAFDLDCAQGVSLFTSKSRSNEAWLEELERRFK.LKDDVELDE..VENLKTEINIKLGILEDKVSYFERLCKEFEEFQNEMKIKTVVNNRRQS-q...............
G8BXX4_TETPH/1-111                  ..............MKGEDRVVYQSIEGLVDKTQEFIDTELAKAISFFSSKSEDNKKWLNEISSTYK.LENEGTMKD..FEELKKAHIKKVDELEQKVVYFEDLYKEINELVEELAVKTKIQKKRQSR................
G8JS86_ERECY/1-107                  .............m---KEKILRHHLDKCVDYTQEHVDLESARAISSFGVDTNANYEWLYELNSRYP.TRKIEEIRT..YQLLKTDYMKKLDNLDGRITYFENLAKELDEFQNEVNIKMQ--------rikrst..........
A0A1G4J6F1_9SACH/1-110              .............m---NEKALKKELEACIVQLQEIANVESAEAISGFEGTIERNYKKLEELKTKFI.LKNGDEDRDraMDV-LDQFDEKLSALETVVEYHEKLADEIDEVLREFKVKKELAENRLSR................
J7RFQ3_KAZNA/90-165                 fhvqradrvqrvva---------------------------------------------REITSSVQ.LKDSAELER..VQMLKEQYSQRIGELELQLDSMERLCGEMEEFLEELNLKRQ--------qrkp............
A0A7H9HSU3_9SACH/1-111              ..............MKETVRNLYQDIERCVDLLQEAVDLETAKAVSLFGEKTFDNERWLEELKQRFQ.LRSDEELEQ..IRSLKTQQANMIDTVESRIEYFEKLCDELEEFQSELEVKTKLAQNRRSR................
BLI1_YEAST/1-110                    ............mg---EQNKLYYDVEKLVNSLQESFDLDCAQSVSLFTSKSRSNEAWLEELENKFK.LKDDVELDD..VENLRAEIDMKLNMLEDKVSYYERLYKELEEFQNEIKIKTVVNNRRQSR................
BLI1_KLULA/1-103                    ...........mrg-----KALKSKLEELVDGIQQRIDFVTATGVSSFEQETEQNYGKLEYLQSK--.IKKDDGISD..WVDEKQRLSGRLNKLEKQVQELEELADEWENYLQLLA-DTK--------lrkdn...........
#=GC seq_cons                       .............h...pp+pLppclEcClstLQEhlDhEsAcuIShFspKoppNppWLc-Lps+ap.LKscsELcp..hcpLKpphhp+L-pLEp+l-YaE+LscElEEFpsElcVKpKltppRpS.................
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