#=GF ID BNIP3
#=GF AC PF06553.16
#=GF DE BNIP3
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_18014 (release 10.0)
#=GF GA 26.00 26.00;
#=GF TC 26.60 26.00;
#=GF NC 24.30 25.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 12690108
#=GF RT CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell
#=GF RT apoptosis.
#=GF RA Lamy L, Ticchioni M, Rouquette-Jazdanian AK, Samson M, Deckert
#=GF RA M, Greenberg AH, Bernard A;
#=GF RL J Biol Chem 2003;278:23915-23921.
#=GF DR INTERPRO; IPR010548;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of several mammalian specific
#=GF CC BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or
#=GF CC BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3
#=GF CC (BH3)-only family, a Bcl-2-related family possessing an atypical
#=GF CC Bcl-2 homology 3 (BH3) domain, which regulates PCD from
#=GF CC mitochondrial sites by selective Bcl-2/Bcl-XL interactions.
#=GF CC BNIP3 family members contain a C-terminal transmembrane domain
#=GF CC that is required for their mitochondrial localisation,
#=GF CC homodimerisation, as well as regulation of their pro-apoptotic
#=GF CC activities. BNIP3-mediated apoptosis has been reported to be
#=GF CC independent of caspase activation and cytochrome c release and
#=GF CC is characterised by early plasma membrane and mitochondrial
#=GF CC damage, prior to the appearance of chromatin condensation or DNA
#=GF CC fragmentation [1].
#=GF SQ 2341
#=GS A0A8D2GHV8_THEGE/77-261 AC A0A8D2GHV8.1
#=GS A0A7K5F060_PROAR/1-185 AC A0A7K5F060.1
#=GS A0A7L3M2M0_9PASS/6-194 AC A0A7L3M2M0.1
#=GS A0A7L4ENB7_HIRRU/5-192 AC A0A7L4ENB7.1
#=GS A0A7K8XAU3_9PICI/1-185 AC A0A7K8XAU3.1
#=GS A0A7J8I3K9_MOLMO/28-204 AC A0A7J8I3K9.1
#=GS A0A6J2X4U0_SITOR/10-115 AC A0A6J2X4U0.1
#=GS A0A8C0QJM8_CHEAB/11-194 AC A0A8C0QJM8.1
#=GS A0A8B8VLB4_BALMU/10-196 AC A0A8B8VLB4.1
#=GS A0A7K9QX34_IRECY/1-152 AC A0A7K9QX34.1
#=GS A0A8C0J8B3_CHEAB/16-207 AC A0A8C0J8B3.1
#=GS H3D732_TETNG/5-176 AC H3D732.1
#=GS A0A8C0A295_BOSMU/28-218 AC A0A8C0A295.1
#=GS A0A8D2DKQ1_SCIVU/10-180 AC A0A8D2DKQ1.1
#=GS A0A7J8BNY8_ROUAE/28-154 AC A0A7J8BNY8.1
#=GS A0A8C0F4K6_BUBBB/1-179 AC A0A8C0F4K6.1
#=GS A0A8C7BXD6_NEOVI/23-200 AC A0A8C7BXD6.1
#=GS A0A6G1Q159_9TELE/12-232 AC A0A6G1Q159.1
#=GS A0A7K5KAJ3_9TYRA/1-98 AC A0A7K5KAJ3.1
#=GS A0A0D8XPT8_DICVI/39-176 AC A0A0D8XPT8.1
#=GS A0A7L2R3F6_9PASS/1-83 AC A0A7L2R3F6.1
#=GS A0A8C4U7S0_FALTI/23-214 AC A0A8C4U7S0.1
#=GS A0A6P5BGD1_BOSIN/56-242 AC A0A6P5BGD1.1
#=GS A0A851D7Y2_TODME/2-190 AC A0A851D7Y2.1
#=GS A0A1A7ZBN8_NOTFU/12-233 AC A0A1A7ZBN8.1
#=GS A0A2Y9KCX7_ENHLU/24-214 AC A0A2Y9KCX7.1
#=GS A0A2K5SH20_CEBIM/28-218 AC A0A2K5SH20.1
#=GS A0A8B9EHR2_ANSCY/1-179 AC A0A8B9EHR2.1
#=GS A0A8D2MI31_ZONAL/16-202 AC A0A8D2MI31.1
#=GS A0A6I9I748_VICPA/29-219 AC A0A6I9I748.1
#=GS A0A8C0ZA90_CYACU/98-287 AC A0A8C0ZA90.1
#=GS A0A7K6TTM7_9AVES/1-152 AC A0A7K6TTM7.1
#=GS A0A7K4VBM7_9EMBE/6-194 AC A0A7K4VBM7.1
#=GS A0A7K9D7X9_9AVES/1-152 AC A0A7K9D7X9.1
#=GS A0A7R9KDP1_9ACAR/45-217 AC A0A7R9KDP1.1
#=GS A0A8J4P751_APTPA/3-192 AC A0A8J4P751.1
#=GS A0A6P6DXD4_OCTDE/25-208 AC A0A6P6DXD4.1
#=GS A0A2I2ZVP5_GORGO/1-178 AC A0A2I2ZVP5.1
#=GS A0A8R1WEY4_BOMMO/8-189 AC A0A8R1WEY4.1
#=GS A0A7K8VQQ2_9STRI/1-98 AC A0A7K8VQQ2.1
#=GS A0A8B9FDY9_9PSIT/24-208 AC A0A8B9FDY9.1
#=GS A0A7L3LGB5_9CHAR/1-98 AC A0A7L3LGB5.1
#=GS A0A8C5Y3L7_MICMU/11-195 AC A0A8C5Y3L7.1
#=GS H2LJD6_ORYLA/10-177 AC H2LJD6.2
#=GS A0A7L2FDY9_QUIME/1-98 AC A0A7L2FDY9.1
#=GS A0A384AZJ0_BALAS/28-218 AC A0A384AZJ0.1
#=GS A0A091EQF6_CORBR/1-190 AC A0A091EQF6.1
#=GS A0A0C2DQE2_9BILA/5-125 AC A0A0C2DQE2.1
#=GS A0A7L1TXI2_PHANI/1-98 AC A0A7L1TXI2.1
#=GS A0A671PXX2_9TELE/10-156 AC A0A671PXX2.1
#=GS A0A7K5MFC6_CARCD/1-98 AC A0A7K5MFC6.1
#=GS A0A7L1XSX7_9AVES/1-98 AC A0A7L1XSX7.1
#=GS A0A094L0S2_ANTCR/1-100 AC A0A094L0S2.1
#=GS A0A8C7A469_NEOVI/16-206 AC A0A8C7A469.1
#=GS A0A3P8UF69_CYNSE/15-224 AC A0A3P8UF69.1
#=GS A0A7L4J8A4_9PASS/2-83 AC A0A7L4J8A4.1
#=GS L5KCR8_PTEAL/61-251 AC L5KCR8.1
#=GS A0A4W4F935_ELEEL/13-232 AC A0A4W4F935.1
#=GS A0A452FMF4_CAPHI/26-194 AC A0A452FMF4.1
#=GS A0A8J4L1H5_APTPA/1-98 AC A0A8J4L1H5.1
#=GS A0A8C1AHF0_CYPCA/1-156 AC A0A8C1AHF0.1
#=GS A0A8C0QWM4_CANLU/1-103 AC A0A8C0QWM4.1
#=GS A0A7K5K0M8_9TYRA/5-192 AC A0A7K5K0M8.1
#=GS A0A3Q3LRW8_9TELE/12-235 AC A0A3Q3LRW8.1
#=GS A0A8C3RCH3_9PASS/39-236 AC A0A8C3RCH3.1
#=GS A0A7L2C3W9_9PASS/5-128 AC A0A7L2C3W9.1
#=GS A0A7K8ZNP7_9PASS/1-98 AC A0A7K8ZNP7.1
#=GS A0A7L4AFX8_9AVES/1-152 AC A0A7L4AFX8.1
#=GS A0A0V1L3J6_9BILA/2569-2730 AC A0A0V1L3J6.1
#=GS A0A850UVJ6_9CORV/6-170 AC A0A850UVJ6.1
#=GS A0A7L1N531_RHICY/1-152 AC A0A7L1N531.1
#=GS A0A7L3R353_9SYLV/1-98 AC A0A7L3R353.1
#=GS A0A7L0P8N1_9AVES/1-98 AC A0A7L0P8N1.1
#=GS A0A7K7BB52_9AVES/1-98 AC A0A7K7BB52.1
#=GS A0A7R8H0Y8_LEPSM/131-184 AC A0A7R8H0Y8.1
#=GS A0A851VRT3_9PASS/2-189 AC A0A851VRT3.1
#=GS A0A7L3LLD7_9CHAR/2-190 AC A0A7L3LLD7.1
#=GS A0A7K8FTL5_9CORV/1-98 AC A0A7K8FTL5.1
#=GS A0A7L0ZQP5_9PASS/1-98 AC A0A7L0ZQP5.1
#=GS A0A7K5WCD9_9SYLV/1-183 AC A0A7K5WCD9.1
#=GS A0A7K6YMQ1_ALCTO/1-185 AC A0A7K6YMQ1.1
#=GS A0A7K8FUG1_9CORV/1-185 AC A0A7K8FUG1.1
#=GS A0A8B9Q769_APTOW/492-671 AC A0A8B9Q769.1
#=GS A0A674BA05_SALTR/18-234 AC A0A674BA05.1
#=GS A0A4W2EVC1_BOBOX/32-208 AC A0A4W2EVC1.1
#=GS A0A7K8IYP4_9PASS/87-179 AC A0A7K8IYP4.1
#=GS A0A0V1CMA5_TRIBR/1446-1606 AC A0A0V1CMA5.1
#=GS A0A2I3GJE9_NOMLE/50-231 AC A0A2I3GJE9.1
#=GS A0A2K6GLP3_PROCO/28-218 AC A0A2K6GLP3.1
#=GS A0A851F7M3_PITSO/1-98 AC A0A851F7M3.1
#=GS A0A7K5TB02_9FRIN/1-98 AC A0A7K5TB02.1
#=GS A0A287APE4_PIG/1-178 AC A0A287APE4.1
#=GS A0A183IY13_9BILA/2-107 AC A0A183IY13.1
#=GS A0A6P4Z234_BRABE/29-220 AC A0A6P4Z234.1
#=GS G1LWI6_AILME/25-207 AC G1LWI6.2
#=GS R7UUN5_CAPTE/10-196 AC R7UUN5.1
#=GS A0A182Y571_ANOST/36-268 AC A0A182Y571.1
#=GS A0A0L7LHP0_OPEBR/77-160 AC A0A0L7LHP0.1
#=GS A0A0A0B4L5_CHAVO/1-152 AC A0A0A0B4L5.1
#=GS A0A5E4MZM1_9HEMI/9-189 AC A0A5E4MZM1.1
#=GS A0A7K5S662_LANLU/1-185 AC A0A7K5S662.1
#=GS A0A4W5K4C6_9TELE/9-223 AC A0A4W5K4C6.1
#=GS L8I712_9CETA/1-189 AC L8I712.1
#=GS A0A852AI06_CALOR/6-192 AC A0A852AI06.1
#=GS A0A5G2QRP7_PIG/11-103 AC A0A5G2QRP7.1
#=GS A0A7L2JDX2_CINMU/74-176 AC A0A7L2JDX2.1
#=GS A0A093Q8A9_9PASS/1-190 AC A0A093Q8A9.1
#=GS A0A6A1PXF6_BALPH/230-400 AC A0A6A1PXF6.1
#=GS A0A212CH82_CEREH/1-84 AC A0A212CH82.1
#=GS A0A7L4EYP7_HIRRU/1-98 AC A0A7L4EYP7.1
#=GS A0A7L3J022_THACH/1-152 AC A0A7L3J022.1
#=GS A0A7N4PFM9_SARHA/27-219 AC A0A7N4PFM9.1
#=GS Q4QRM2_DANRE/9-186 AC Q4QRM2.1
#=GS A0A1Y1LKJ2_PHOPY/7-184 AC A0A1Y1LKJ2.1
#=GS A0A7L4ESF6_HIRRU/1-152 AC A0A7L4ESF6.1
#=GS A0A851AYU1_PICGY/5-194 AC A0A851AYU1.1
#=GS A0A8C6ZIN0_NOTPE/23-216 AC A0A8C6ZIN0.1
#=GS A0A7K4Q643_MELMO/1-152 AC A0A7K4Q643.1
#=GS W5Q9X6_SHEEP/31-218 AC W5Q9X6.1
#=GS A0A6P5M0Y5_PHACI/27-217 AC A0A6P5M0Y5.1
#=GS A0A7K8V3A5_9STRI/1-152 AC A0A7K8V3A5.1
#=GS A0A8C2TL62_COTJA/118-309 AC A0A8C2TL62.1
#=GS A0A093PW83_9PASS/1-186 AC A0A093PW83.1
#=GS A0A5N5TBR7_9CRUS/134-312 AC A0A5N5TBR7.1
#=GS A0A672P3N1_SINGR/21-222 AC A0A672P3N1.1
#=GS A0A7K9TSI7_9AVES/19-118 AC A0A7K9TSI7.1
#=GS A0A8U8AQB2_GEOPR/7-201 AC A0A8U8AQB2.1
#=GS H3D9U6_TETNG/9-184 AC H3D9U6.1
#=GS A0A6J2QRC6_COTGO/15-223 AC A0A6J2QRC6.1
#=GS A0A6J0TXT8_9SAUR/84-180 AC A0A6J0TXT8.1
#=GS A0A0V0VCG6_9BILA/2447-2608 AC A0A0V0VCG6.1
#=GS A0A671Z095_SPAAU/14-222 AC A0A671Z095.1
#=GS A0A672KJG7_SINGR/65-154 AC A0A672KJG7.1
#=GS A0A3S2MF43_ORYJA/9-180 AC A0A3S2MF43.1
#=GS A0A5E4BA07_MARMO/29-219 AC A0A5E4BA07.1
#=GS A0A8C9Y026_SANLU/14-222 AC A0A8C9Y026.1
#=GS A0A6G1QHW8_9TELE/14-222 AC A0A6G1QHW8.1
#=GS A0A8C8K2Q0_ONCTS/14-232 AC A0A8C8K2Q0.1
#=GS A0A4W5LZQ9_9TELE/12-230 AC A0A4W5LZQ9.1
#=GS A0A250YBN7_CASCN/10-194 AC A0A250YBN7.1
#=GS A0A8C6I7S4_MUSSI/5-63 AC A0A8C6I7S4.1
#=GS A0A4U5UYM3_COLLU/12-235 AC A0A4U5UYM3.1
#=GS A0A2K6FMB5_PROCO/12-194 AC A0A2K6FMB5.1
#=GS A0A7L3V7M0_MOLAT/6-194 AC A0A7L3V7M0.1
#=GS A0A7K7S1L2_9PASS/1-152 AC A0A7K7S1L2.1
#=GS A0A6P6D213_PTEVA/1-157 AC A0A6P6D213.1
#=GS A0A7L4CXI8_9AVES/11-117 AC A0A7L4CXI8.1
#=GS A0A384AZE9_BALAS/1-178 AC A0A384AZE9.1
#=GS A0A0V1L532_9BILA/2574-2735 AC A0A0V1L532.1
#=GS A0A7K7U1F8_9CHAR/3-178 AC A0A7K7U1F8.1
#=GS A0A7L1AU21_GYMTI/1-152 AC A0A7L1AU21.1
#=GS A0A4X2KY34_VOMUR/15-200 AC A0A4X2KY34.1
#=GS A0A7L3WZH5_9GRUI/1-98 AC A0A7L3WZH5.1
#=GS A0A7L1H1Y2_9PICI/1-98 AC A0A7L1H1Y2.1
#=GS A0A7K9ERT8_BARMA/4-178 AC A0A7K9ERT8.1
#=GS A0A667Y107_9TELE/9-188 AC A0A667Y107.1
#=GS A0A8C3ARI3_CYCLU/9-189 AC A0A8C3ARI3.1
#=GS A0A671V3L9_SPAAU/41-223 AC A0A671V3L9.1
#=GS A0A7K6UEV3_9AVES/1-98 AC A0A7K6UEV3.1
#=GS A0A0Q9XPF9_DROMO/1-177 AC A0A0Q9XPF9.1
#=GS A0A7K4YYJ7_BUCAB/1-177 AC A0A7K4YYJ7.1
#=GS A0A7K6X5V4_9PASE/6-194 AC A0A7K6X5V4.1
#=GS A0A8B9ZX21_9AVES/71-264 AC A0A8B9ZX21.1
#=GS A0A7L2R511_9PASS/1-98 AC A0A7L2R511.1
#=GS A0A8C5Y633_MICMU/9-191 AC A0A8C5Y633.1
#=GS A0A7M7R7D0_APIME/10-191 AC A0A7M7R7D0.1
#=GS A0A0A0AGM8_CHAVO/1-186 AC A0A0A0AGM8.1
#=GS A0A226P460_COLVI/23-204 AC A0A226P460.1
#=GS A0A7L2AAD1_LEILU/1-143 AC A0A7L2AAD1.1
#=GS A0A8C0BFL0_9AVES/6-187 AC A0A8C0BFL0.1
#=GS A0A6P7X512_9AMPH/8-215 AC A0A6P7X512.1
#=GS A0A5F5Y5F2_FELCA/20-187 AC A0A5F5Y5F2.1
#=GS A0A7K9UZW5_ANSSE/1-98 AC A0A7K9UZW5.1
#=GS A0A8C5WP07_LATLA/21-213 AC A0A8C5WP07.1
#=GS A0A7K7LES7_9AVES/1-98 AC A0A7K7LES7.1
#=GS A0A7L1P0Q6_RHICY/1-188 AC A0A7L1P0Q6.1
#=GS A0A7K7CAW4_APHCE/1-98 AC A0A7K7CAW4.1
#=GS A0A851Y7Q4_EOLRO/1-152 AC A0A851Y7Q4.1
#=GS A0A7L0CB66_9AVES/21-151 AC A0A7L0CB66.1
#=GS A0A093NW21_PYGAD/1-189 AC A0A093NW21.1
#=GS A0A553REW4_9TELE/9-178 AC A0A553REW4.1
#=GS A0A7K8SLU8_9AVES/3-178 AC A0A7K8SLU8.1
#=GS A0A6I9MHE7_PERMB/1-178 AC A0A6I9MHE7.1
#=GS A0A4W5LNH5_9TELE/24-243 AC A0A4W5LNH5.1
#=GS A0A7L3P3D4_9DEND/1-98 AC A0A7L3P3D4.1
#=GS A0A158QXR0_NIPBR/37-168 AC A0A158QXR0.1
#=GS A0A8C7D6L7_ONCKI/24-242 AC A0A8C7D6L7.1
#=GS A0A4W4EG74_ELEEL/9-193 AC A0A4W4EG74.1
#=GS A0A6G0V5A3_9BILA/1131-1291 AC A0A6G0V5A3.1
#=GS A0A8V5FLB9_MELUD/7-202 AC A0A8V5FLB9.1
#=GS A0A7L3YV91_FREGA/1-98 AC A0A7L3YV91.1
#=GS A0A452FZP7_CAPHI/39-226 AC A0A452FZP7.1
#=GS A0A8C5WIJ0_9ANUR/26-219 AC A0A8C5WIJ0.1
#=GS A0A834FCF6_ORYME/9-180 AC A0A834FCF6.1
#=GS A0A671M3P4_9TELE/9-163 AC A0A671M3P4.1
#=GS A0A6P3HGJ0_BISBI/28-218 AC A0A6P3HGJ0.1
#=GS A0A803W245_FICAL/20-209 AC A0A803W245.1
#=GS A0A6J3PUZ8_TURTR/85-263 AC A0A6J3PUZ8.1
#=GS A0A7J8G4Z6_ROUAE/10-194 AC A0A7J8G4Z6.1
#=GS A0A7L0MXY0_9PASS/1-185 AC A0A7L0MXY0.1
#=GS A0A852PHJ9_9PASS/6-194 AC A0A852PHJ9.1
#=GS A0A6I9X1Y0_9HYME/2-185 AC A0A6I9X1Y0.1
#=GS A0A8D0GKE6_SPHPU/35-175 AC A0A8D0GKE6.1
#=GS A0A7K6IZG1_9CORV/1-152 AC A0A7K6IZG1.1
#=GS A0A3Q0E3N2_CARSF/28-204 AC A0A3Q0E3N2.1
#=GS A0A6P6P5D4_CARAU/9-177 AC A0A6P6P5D4.1
#=GS A0A7L1DDX5_9PASS/1-98 AC A0A7L1DDX5.1
#=GS A0A2Y9J634_ENHLU/10-195 AC A0A2Y9J634.1
#=GS A0A8C0IYB5_CHEAB/7-190 AC A0A8C0IYB5.1
#=GS A0A8C7ENH7_NEOVI/28-209 AC A0A8C7ENH7.1
#=GS A0A4W4EFB0_ELEEL/9-196 AC A0A4W4EFB0.1
#=GS A0A8C4MFP1_EQUAS/10-194 AC A0A8C4MFP1.1
#=GS A0A5N4DKC7_CAMDR/39-222 AC A0A5N4DKC7.1
#=GS A0A3Q7TDN8_VULVU/28-218 AC A0A3Q7TDN8.1
#=GS A0A7K9T6V7_9AVES/1-98 AC A0A7K9T6V7.1
#=GS A0A811ZE06_NYCPR/28-218 AC A0A811ZE06.1
#=GS A0A6J0VIL6_ODOVR/2-178 AC A0A6J0VIL6.1
#=GS A0A7L2M400_9SYLV/1-185 AC A0A7L2M400.1
#=GS A0A7K7FFI4_CHIMN/3-192 AC A0A7K7FFI4.1
#=GS A0A8M2BKA1_DANRE/9-196 AC A0A8M2BKA1.1
#=GS A0A7M4F7T7_CROPO/27-216 AC A0A7M4F7T7.1
#=GS A0A7L4M4Y3_GLAPT/1-98 AC A0A7L4M4Y3.1
#=GS A0A0K0D0H4_ANGCA/51-181 AC A0A0K0D0H4.1
#=GS A0A8C4NF65_EPTBU/70-259 AC A0A8C4NF65.1
#=GS A0A3P9QEQ4_POERE/14-204 AC A0A3P9QEQ4.1
#=GS A0A7K8KB22_9GRUI/1-98 AC A0A7K8KB22.1
#=GS A0A7K9HIV8_9AVES/1-98 AC A0A7K9HIV8.1
#=GS V8NP03_OPHHA/42-222 AC V8NP03.1
#=GS A0A4W4EFB6_ELEEL/27-198 AC A0A4W4EFB6.1
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A0A7L0Y9T0_9PASE/1-98 ...................................................................................................edfle-----.-.--------...-...-...-----...-...............................................................................................----.--.-...--....--...-.-.--...-.-.....-.-.---------..-..-.--..-....-....-.............-....-....--......---.........--.--........--.--...........................................................---.-.-...-..-.-.-.--.--..-...----...............--R.R.R...E.V.....E...R..L.......L.R....KN..ADWI......WD.WS.SRP..EN.I..P.P....K...........EF...L...F.KH..PR.........................R.....TATLSM.....R.N.T...S...V...M.K...KG..gIFSA.E.FLKVFLPSLLLSHL....LAI.GL...........G.IYIGRRLTTTASS-s....................................................
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