#=GF ID   Bc2l-C_N
#=GF AC   PF21592.1
#=GF DE   Bc2l-C, N-terminal domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   ECOD:EF20608
#=GF GA   27.00 27.00;
#=GF TC   33.80 84.50;
#=GF NC   26.30 23.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0100
#=GF RC   Paper describing PDB structure 2wq4
#=GF RN   [1]
#=GF RM   20152153
#=GF RT   A TNF-like trimeric lectin domain from Burkholderia cenocepacia
#=GF RT   with specificity for fucosylated human histo-blood group
#=GF RT   antigens.
#=GF RA   Sulák O, Cioci G, Delia M, Lahmann M, Varrot A, Imberty A,
#=GF RA   Wimmerová M.
#=GF RL   Structure. 2010 Jan 13;18(1):59-72
#=GF RC   Paper describing PDB structure 6zzw
#=GF RN   [2]
#=GF RM   33769626
#=GF RT   Prediction and Validation of a Druggable Site on Virulence
#=GF RT   Factor of Drug Resistant Burkholderia cenocepacia*.
#=GF RA   Lal K, Bermeo R, Cramer J, Vasile F, Ernst B, Imberty A,
#=GF RA   Bernardi A, Varrot A, Belvisi L;
#=GF RL   Chemistry. 2021;27:10341-10348.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found at the N-terminal end of Lectin from
#=GF CC   Burkholderia cenocepacia (Bc2l-C) and similar bacterial
#=GF CC   sequences. Bc2l-C is a soluble lectin involved in bacterial
#=GF CC   adhesion and subsequent deadly infection to the host. It has two
#=GF CC   domains: a C-terminal domain Pfam:PF07472 and this domain, which
#=GF CC   adopts a compact jellyroll architecture composed of 11
#=GF CC   beta-strands and a short helix. It shows specificity for
#=GF CC   fucosylated human histo-blood group epitopes H-type 1, Lewis b,
#=GF CC   and Lewis Y [1,2].
#=GF SQ   5
#=GS A0A0D7PJ28_9BRAD/8-125   AC A0A0D7PJ28.1
#=GS T0P0S6_PHOTE/9-131       AC T0P0S6.1
#=GS A0A5P8WH24_9NOSO/31-153  AC A0A5P8WH24.1
#=GS Q7MZP1_PHOLL/12-132      AC Q7MZP1.1
#=GS W1IRN0_9GAMM/12-132      AC W1IRN0.1
A0A0D7PJ28_9BRAD/8-125              ..sg--PHATNS-SSWTPIPGLALTLP---EGIGTTAIVI-LDVPNPFAQGNNFPGGNFGITINGTPSSVVAVFTYNEQVPQSTGRIPTTLVVGVPLGNK..PQAIVGVWSGIRGSTVNIDTPATLTA-l
T0P0S6_PHOTE/9-131                  ..dt--TISTSSDDSWEDIPGLSISVIEHSLKRSTKALII-LNIPTPYASGNDYPAVTFAI-TMNSKVLASSTISYDYSRPDSFGRRPATVQTCIDLTDTnsLGSIQAKWKASRKSIGHIDSYCSISAI.
A0A5P8WH24_9NOSO/31-153             tgaq----QTIGSDTYTDIKGLTLILPQANLLSGQTNAIVTLNLPIPYAQGANFPGITYRILAD-GVEVGSGGFTYISQQPQSFGRVPSTLVANVQLSTT.kQTVVTAQWLGVRGSIGIIDTYASLSAV.
Q7MZP1_PHOLL/12-132                 ....SNPLQTS-SQNYVDIPGLKLDVSKYSNSPCLTA-LITLNIPTPYASGNNFPGGNFAIVTDQGEQLAYGGFTYSSKIPENSGRMPFTLVARYSLASN..VSTIKAQWSNIRGSTVHIDSYASISAV.
W1IRN0_9GAMM/12-132                 ....NNPIQTSS-SNYVDIPGLEINVSRYSDSPGLTA-LITLNVPTPYASGNNFPGGNFIIITDQGEQLASGGFTYSNKSPESYGRMPFTLVTSCSLASN..ISIIKAQWSNVRGSTVHIDSYASISAV.
#=GC seq_cons                       ..st..PlQTSSssoYsDIPGLsLsVscaSpusGpTAhlITLNlPTPYASGNNFPGGNFuIlTDpGcpLASGGFTYssppP-SaGRhPsTLVsslsLuos..losIpAQWSulRGSTVHIDSYASISAV.
//