#=GF ID   Birna_VP2
#=GF AC   PF01766.21
#=GF DE   Birnavirus VP2 protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_946 (release 4.2)
#=GF GA   27.00 27.00;
#=GF TC   355.50 355.50;
#=GF NC   19.20 18.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Birnaviridae
#=GF CL   CL0055
#=GF RN   [1]
#=GF RM   2828658
#=GF RT   Birnavirus precursor polyprotein is processed in Escherichia
#=GF RT   coli by its own virus-encoded polypeptide. 
#=GF RA   Jagadish MN, Staton VJ, Hudson PJ, Azad AA; 
#=GF RL   J Virol 1988;62:1084-1087.
#=GF RN   [2]
#=GF RM   8525637
#=GF RT   Strain variability and localization of important epitopes on the
#=GF RT   major structural protein (VP2) of infectious pancreatic necrosis
#=GF RT   virus. 
#=GF RA   Heppell J, Tarrab E, Lecomte J, Berthiaume L, Arella M; 
#=GF RL   Virology 1995;214:40-49.
#=GF DR   INTERPRO; IPR002662;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   VP2 is the major structural protein of birnaviruses [2]. The
#=GF CC   large RNA segment of birnaviruses codes for a polyprotein
#=GF CC   (N-VP2-VP4-VP3-C) [1].
#=GF SQ   11
#=GS G9I7F9_9VIRU/2-442      AC G9I7F9.1
#=GS POLS_IBDVU/9-452        AC Q82635.1
#=GS POLS_BSNV/7-428         AC Q8AZM0.1
#=GS POLS_IPNVS/5-453        AC Q703G9.1
#=GS Q2PBR5_9VIRU/11-462     AC Q2PBR5.1
#=GS D3GMG2_9VIRU/7-478      AC D3GMG2.1
#=GS A0A4P8PKK9_9VIRU/7-429  AC A0A4P8PKK9.1
#=GS D0U495_9VIRU/1-431      AC D0U495.1
#=GS POLS_IBDVB/9-452        AC Q9WI42.1
#=GS POLS_DXV96/2-442        AC Q96724.1
#=GS POLS_IPNVJ/5-453        AC P05844.2
G9I7F9_9VIRU/2-442                 ...NTSNEYLKTLLDPAQFIADIPDDIMIRHINRAETITYNLKTGASGTGLIVFYPNTPSSVAGFHYRWDAEN.SVWAFDQY...IYTAQELKKSYDYGRLISGAVSVKSSSIPSGVYALTGTFNAVWFQGTLSE..VS.NLNYDRILSITSNPLDKVGNVLVGDGLAVLSLPQGFNNPYVRLGDESPSSLTSVTHITNTSQNLGYGGAFAVP..........QTTVAGQGT...FFKEFNINVDSVGPIDVtwSGLMTMQ....---D...EWTVTANYQPLNLSG....TLIQGSMR....TIIWSN.VGVSNGTHYMN.LNEINVS.FFH.ENPPPEPVAAIKVHITFGNNTNGES..............SMNVD.GSFTFHVV..GGATIGVNSPTVMIGYQGVASGSTITLSGVNNYELVPNPALQKNLPMSYGTCDPTDLNYVKYILSNREKLGIRSVMTLAQYAKMKMQMNIMTDYHVGDRE..ASSFDFWHLLKQIK..
POLS_IBDVU/9-452                   ...QQIVPFIRSLLMPTTGPASIPDDTLEKHTLRSETSTYNLTVGDTGSGLIVFFPGFPGSIVGAHYTLQ-SN.GNYKFDQM...LLTAQNLPASYNYCRLVSRSLTVRSSTLPGGVYALNGTINAVTFQGSLSE..LT.DVSYNGLMSATANINDKIGNVLVGEGVTVLSLPTSYDLGYVRLGDPIPAIGLDPKMV-ATCDSSDRPRVYTITaad...dyqfSSQYQAGGV...TITLFSANIDAITSLSI..GGELVFQ....TSVQ...GLILGATIYLIGFDG....TAVITRA-....VAADN-.-GLTAGTDNLM.PFNI---.VIP.TSEITQPITSIKLEIVT-SKSGGQAgd..........qmSWSAS.GSLAVTIH..GGNYPGALRPVTLVAYERVATGSVVTVAGVSNFELIPNPELAKNLVTEYGRFDPGAMNYTKLILSERDRLGIKTVWPTREYTDFREYFMEVADLNSPLKI..AGAFGFKDIIRALR..
POLS_BSNV/7-428                    ...NTQIRYLNSLLVPETGSTSIPDDTLDRHCLKTETTTENLVAALGGSGLIVLFPNSPSGLLGAHYTKT-PQ.GSLIFDKA...ITTSQDLKKAYNYARLVSRIVQVRSSTLPAGVYALNGTFNGVTYIGSLSE..IK.DLDYNSLLSATANINDKVGNVLVGDGVAVLSLPAGSDLPYVRLGDEVPSSAGV-----ARCSPSDRPRHYNAN..........NKQVQVGTT...DTKTNGFNIDATTPTEV..TVDMQIA....QIAA...GKTLTVTVKLMGLTG....AKVASRSE....TVSGN-.-GGT-------.-FHFSTTaVFG.ETEITQPVVGVQVL----AKTNGD-..............PIVVD.SYVGVTVH..GGNMPGTLRPVTIIAYESVATGSVLTLSGISNYELIPNPELAKNIQTSYGKLNPAEMTYTKVVLSHRDELGLRSIWSIPQYRDMMSYFREVSDRSSPLKI..AGAFGWGDLLSGIR..
POLS_IPNVS/5-453                   ...KATATYLKSIMLPETGPASIPDDITERHILKQETSSYNLEVSESGSGVLVCFPGAPGSRIGAHYRWNANQ.TGLEFDQW...LETSQDLKKAFNYGRLISRKYDIQSSTLPAGLYALNGTLNAATFEGSLSE..VE.SLTYNSLMSLTTNPQDKVNNQLVTKGVTVLNLPTGFDKPYVRLEDETPQGLQSMNGAKMRCTAAIAPRRYEIDlp.....sqrLPPVPATGT...LTTLYEGNADIVNSTTV..TGDINFSl.aeQPAD...ETKFDFQLDFMGLDNdvpvVTVVSSVL....ATNDNY.RGVSA------.----KMTqSIP.TENITKPITRVKLSYKINQQTAIGNva..........tlGTMGP.ASVSFSSG..NGNVPGVLRPITLVAYEKMTPLSILTVAGVSNYELIPNPELLKNMVTRYGKYDPEGLNYAKMILSHREELDIRTVWRTEEYKERTRVFNEITDFSSDLPT..SKAWGWRDIVRGIR..
Q2PBR5_9VIRU/11-462                trk---SPYIKSLLLPETGPASIPDDKIRRHVKRSESTTTNLTS-TTGKGMLIVYNNHPKNLVGSHYTYA-SD.GKLRFDRN...LYTAQDLSKNFNYGRKVSQLVTIKSTQLPAGVYAMQGTMNGVCIDGAPSE..VEtALKYETILSASTNALDKVAGVLVNDGVGVLSLPTTFDNDYIRMGDPAPSSFTP--GSAQLSKPTHNPGLNSIVtagttgltsgTKTISTTKT...IISTDVINVDSTEGLLL..DLNIQLMrwgvPSGK...TATVTVDVKTVDLAG....AETDAEQR....EIKIS-.-GTNTGRDNVItLSGLMMG.LSG.KKPLVAPTAAVVIEVSAISSESMTL..............THSGHiNNYSLTSL..CAGTPGTTNPITIIIYTDLTPGGIMTVTAVSNFELIPNAELRKNIPTDFGNSDPSEMDFIKRILGQRETLELRTIWDMGMYDARRDVLSEFAHLD-DNSL..AMAWEWSDVLWWI-k.
D3GMG2_9VIRU/7-478                 .tr--TSKYLKSILNPASGPCHIPDDIVTRCSLRSETTTYNITAPGSGQGIFIFYPNSPFGWCGYHYTFD--G.TKYLYDNItgpLDTAQNLDQNYNYSRLVSQLLTLRSSTLPAGVYALNGTFNAITYDGCVSEanLP.TTQYGQLLSLNSDVIDKVGNVLVGDGVAILSLPNRFDVPFCRMNDPAPSTGNTGALFRSSIVDATANLRYEMQ..........MAPIAIGAMpayNTILASINVDNVRSISV..RGNIPLI....NSSRlnvTSVITYNVLYQDFTG....ATIYQETKaapiTIDPNYaTGPNNQGGCSF.MVESTFS.AMPaGAKHTQPVAAVAFSIANIVQPTVSSwdvnefgfapfsnvSTEST.SSITLTVEavSAAFPGMNSPVTVVAYQGLAGGSVLTLSGVSNYELIPNPSLKKNLPTSYGRHDPAELNYVKMVLANREELGVKTVFALPEYKQLLTRLEEFYNLDTN-TY..AEAFDWGKLLRTIK..
A0A4P8PKK9_9VIRU/7-429             ..s-TVVPYLKSLLMPDTGPASIPDDNIERHTIKSEPTTYNLTVGESGSGIIVLYPNSPNSPLGAHYKRDKNNpSKLIFDRA...ITTSQDLKKAYNFGRLVSRVLSAKSSTLPSGVYSLNGTLSAVTYIGSLSE..IG.DLDYNKILSTTANHNDKVGNVLAREGVTVLALPTGFDLQFTRMGDDSPSSEGA-----ATVDPSSQPRVYSAQa........eTSQTITTGT...SKNLIAHNLDAITPVTV..QTHVSLT....---T...TSPTSVEISLIGLDE....SKVVTHNA....IISGT-.TGTLT------.-QDV-TA.IFT.QADIKQPIVAMTVKVTA-----AAD..............ITAAQ.IQTRTTVH..GGDAPGVLRPVTIVAYETLAENSILTLAGVSNYELIPNPELSKNIVATYGKLNPQEMLYTKVVLSHRDEIGLKSVWATDQYKDFRAYFAEVADISKPLQI..AGAFGWGDVLGF--lr
D0U495_9VIRU/1-431                 .ms---NEYLRSILMPERGPSSIPDDNVRRHCVRQETITANIVVGSSGKGAFVLFPNNPSSLIGAHFKYDDQG.KSYKYTQS...LVVAQRLNESYNYGRKSAGVIYIRSSTLPSGVYNISGTINAATYEGPPSE..VG.LPEYNKILSITSNPMDKLGNVGVLEGVAVLTLPASYDIDYTRLADLSPSSAKNGCVVNDSGQSLIYTQYDEIN..........Y----TGSQ...EKQLLSFNIDSNILVTT..TATLDFY....TTAS...DAQVTIKIKYLGIDG....LVVSENEI....ISRIDS.LERTVSIDAFY.PFPQ---.VI-.KEGGQEPVAAVELYLTSDKSTSITG..............TI---.-RSITTAH..SAARPGITSPTTIVAYEGVQSGASITVAGVSNYELIPNPELARNMETRYARTDPYGMIYTKYVLANRDRLGIRSVWPTNDYKARFPLFEELGLMQSDASIteAMAFGIHDVISWIR..
POLS_IBDVB/9-452                   ...QQIVPFIRSLLMPTTGPASIPDDTLEKHTLRSETSTYNLTVGDTGSGLIVFFPGFPGSIVGAHYTLQ-GN.GNYKFDQM...LLTAQNLPASYNYCRLVSRSLTVRSSTLPGGVYALNGTINAVTFQGSLSE..LT.DVSYNGLMSATANINDKIGNVLVGEGVTVLSLPTSYDLGYVRLGDPIPAIGLDPKMV-ATCDSSDRPRVYTITaad...dyqfSSQYQPGGV...TITLFSANIDAITSLSV..GGELVFR....TSVH...GLVLGATIYLIGFDG....TTVITRA-....VAANN-.-GLTTGTDNLM.PFNL---.VIP.TNEITQPITSIKLEIVT-SKSGGQAgd..........qmSWSAR.GSLAVTIH..GGNYPGALRPVTLVAYERVATGSVVTVAGVSNFELIPNPELAKNLVTEYGRFDPGAMNYTKLILSERDRLGIKTVWPTREYTDFREYFMEVADLNSPLKI..AGAFGFKDIIRAIR..
POLS_DXV96/2-442                   ...NTTNEYLKTLLNPAQFISDIPDDIMIRHVNSAQTITYNLKSGASGTGLIVVYPNTPSSISGFHYIWDSAT.SNWVFDQY...IYTAQELKDSYDYGRLISGSLSIKSSTLPAGVYALNGTFNAVWFQGTLSE..VS.DYSYDRILSITSNPLDKVGNVLVGDGIEVLSLPQGFNNPYVRLGDKSPSTLSSPTHITNTSQNLATGGAYMIP..........VTTVPGQGF...HNKEFSINVDSVGPVDIlwSGQMTMQ....---D...EWTVTANYQPLNISG....TLIANSQR....TLTWSN.TGVSNGSHYMN.MNNLNVS.LFH.ENPPPEPVAAIKININYGNNTNGDS..............SFSVD.SSFTINVI..GGATIGVNSPTVGVGYQGVAEGTAITISGINNYELVPNPDLQKNLPMTYGTCDPHDLTYIKYILSNREQLGLRSVMTLADYNRMKMYMHVLTNYHVDERE..ASSFDFWQLLKQIK..
POLS_IPNVJ/5-453                   ...KATATYLRSIMLPENGPASIPDDITERHILKQETSSYNLEVSESGSGLLVCFPGAPGSRVGAHYRWNLNQ.TALEFDQW...LETSQDLKKAFNYGRLISRKYDIQSSTLPAGLYALNGTLNAATFEGSLSE..VE.SLTYNSLMSLTTNPQDKVNNQLVTKGITVLNLPTGFDKPYVRLEDETPQGPQSMNGARMRCTAAIAPRRYEIDlp.....serLPTVAATGT...PTTIYEGNADIVNSTAV..TGDITFQl.eaEPVN...ETRFDFILQFLGLDNdvpvVTVTSSTL....VTADNY.RGASA------.----KFTqSIP.TEMITKPITRVKLAYQLNQQTAIANaa..........tlGAKGP.ASVSFSSG..NGNVPGVLRPITLVAYEKMTPQSILTVAGVSNYELIPNPDLLKNMVTKYGKYDPEGLNYAKMILSHREELDIRTVWRTEEYKERTRAFKEITDFTSDLPT..SKAWGWRDLVRGIR..
#=GC seq_cons                      ...pthspYL+SLLhPpoGPASIPDDhlcRHsl+uEToTYNLssusSGoGllVhaPNsPuSllGAHYpas.ss.ushtFDQh...LhTAQ-LccuYNYGRLlSphlol+SSTLPuGVYALNGThNAVTapGoLSE..ls.slsYNplLShToNs.DKVGNVLVs-GVsVLSLPsuFDhsYVRLGD.sPSohps.phhtsosssustPphYpIs..........hspltssGs...ppplhuhNlDulsslsV..sGplshp....psss...stslosslphlGlsG....spVsspsh....shsss..hGsost.t......ph.hs.lhs.pstlspPlsulclplsh.spossss..............ohsus.uShshTlt..uGshPGshpPlTlVAYEslAsGSllTluGVSNYELIPNPELtKNlsTpYG+hDPtshsYsKhILSpR-cLGlRoVWshs-YcchpphFpElsDhsoshph..AtAFGatDll+tI+..
//