#=GF ID   Birna_VP4
#=GF AC   PF01768.20
#=GF DE   Birnavirus VP4 protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_946 (release 4.2)
#=GF GA   24.00 24.00;
#=GF TC   28.20 26.10;
#=GF NC   23.50 22.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Birnaviridae
#=GF RN   [1]
#=GF RM   2828658
#=GF RT   Birnavirus precursor polyprotein is processed in Escherichia
#=GF RT   coli by its own virus-encoded polypeptide. 
#=GF RA   Jagadish MN, Staton VJ, Hudson PJ, Azad AA; 
#=GF RL   J Virol 1988;62:1084-1087.
#=GF DR   INTERPRO; IPR025775;
#=GF DR   MEROPS; S50;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   VP4 is a viral protease [1]. The large RNA segment of
#=GF CC   birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [1].
#=GF SQ   11
#=GS G9I7F9_9VIRU/444-698      AC G9I7F9.1
#=GS POLS_IPNVJ/455-706        AC P05844.2
#=GS POLS_BSNV/431-756         AC Q8AZM0.1
#=GS POLS_IPNVS/455-706        AC Q703G9.1
#=GS D3GMG2_9VIRU/480-734      AC D3GMG2.1
#=GS POLS_IBDVB/454-722        AC Q9WI42.1
#=GS POLS_DXV96/444-702        AC Q96724.1
#=GS Q2PBR5_9VIRU/467-809      AC Q2PBR5.1
#=GS D0U495_9VIRU/434-694      AC D0U495.1
#=GS POLS_IBDVU/454-722        AC Q82635.1
#=GS A0A4P8PKK9_9VIRU/585-764  AC A0A4P8PKK9.1
G9I7F9_9VIRU/444-698                 .........l-VVPVASTMLPQFAPIIGAADNLANTVLGN..---SASGQPIGNS.ASGL................PISMTRRIKSAHSADTP............................................................................................IGDSNWEPTRNPEFNKLDVi.....ydVSHS.S...MALFPVIMMD.NDQVVPSDPEELFIAVslTESLRKQI--PGIDTMPYYTIGGHRVYNAVS....N.GrV.........STAPF.LTS......DYILLPCYQL.F..DGK......LATS..KTP-NKVTGTSHQLALyAAEGLQKRGIMGKAPY.AAFTGS..VAGQ..SVGEVFGISL...KSQLTDSLGIPLFGNSQGL--------------piqnlhqle.......
#=GR G9I7F9_9VIRU/444-698      pAS   .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
POLS_IPNVJ/455-706                   ..........VAAPVLSTLFPMAAPLIGA----ADQFIGDltKTNSAGGRYLSHA.AGGRyhdvmd...swasgseAGSYSKHLKTRLESNNY............................................................................................--EEVELPKPTKG------........----.-...-VIFPVVHTV.--ESAPGEAFGSLVVV..IPEAYPELLDPNQQVLSYFKNDTGCVWGIGE....D.-.-.........IPFEG.DDM......CYTALPLKEIkR..NGN......IVVE..KIFAGPAMGPSSQLAL.---SLLVNDIDEGIPR.MVFTGE..IADDeeTVIPICGVDI...KAIAAHEHGLPLIGCQPGVDEMVANTSLASHLI................
#=GR POLS_IPNVJ/455-706        pAS   .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
POLS_BSNV/431-756                    ........vf---PVVDTLLPAARPLTDLASGWIKNKYP-..--EAASGRPL--A.ASGR................PMAASGTFSKRIPLASSdeidyqsvlaltipgthpklvppterepnstpdghkitg.............aktkdntggdvtvvkpldwlfklpclrpqaadlpisllqtL------AYKQPLGRNSRI........VHFT.D...GALFPVVAFG.DNH----STSELYIAV..RGD-HRDLMSPDVRDSYALTGDDHKVWGATH....H.T.YyvegapkkpLKFNVkTRT......DLTILPVADVfWraDGS......ADVDvvWNDMPAVAGQSSSIAL.ALASSLPF-----VPK.AAYTGC..LSGT..NVQPVQFGNL...KARAAHKIGLPLVGM------------------tqdggedtrictl...
#=GR POLS_BSNV/431-756         AS    .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
POLS_IPNVS/455-706                   ..........VAAPVLSTLFPMAAPLIGM----ADQFIGDltKTNAAGGRYHSMA.AGGRykdvle...swasggpDGKFSRALKNRLESANY............................................................................................--EEVELPPPSKG------........----.-...-VIVPVVHTV.--KSAPGEAFGSLAII..IPGEYPELLDANQQVLSHFANDTGSVWGIGE....D.-.-.........IPFEG.DNM......CYTALPLKEIkR..NGN......IVVE..KIFAGPIMGPSAQLGL.---SLLVNDIEDGVPR.MVFTGE..IADDeeTIIPICGVDI...KAIAAHEQGLPLIGNQPGVDEEVRNTSLAAHLI................
#=GR POLS_IPNVS/455-706        AS    .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
D3GMG2_9VIRU/480-734                 ..........IAVPTLSTIFPQFGPLIGAGSALGDELLKS..--FAASG--TAIA.ASGTpitr.......asavtPGVDLVDLRNYAMDNWD............................................................................................IVN-MDLQNLTYNSQMLYTkklyvgerLSSE.GpprGVLFPTITMR.NNA-----LMSHMIYL.aVPGNWSSRLPMNVRDNYSETANGKRIWGIAN....T.-.Y.........LGHIM.TNQ......DITLLPILSI.Q..GGF......AIIP..DE-APILEGTSCVSAI.--LCAYRGDF-QGIPP.ALVTGNakLIEGryVVMPNPAQQM...KKQIAAQKELKFIGA------------------dlsg............
#=GR D3GMG2_9VIRU/480-734      pAS   .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
POLS_IBDVB/454-722                   ..........IAVPVVSTLFPPAAPLAHAIGEGVDYLLGD..EAQAASG--TARA.ASGK................ARAASGRIRQLTLAADKgyevvanlfq........................................................................vpqnpvvdgiLAS----PGVLRGAHNLDC........VLRE.G...ATLFPVVITTvEDAMTPKALNSKMFAV..IEGVREDLQPPSQRGSFIRTLSGHRVYGYAP....D.G.V.........LPLET.GRD......-YTVVPIDDV.W..DDS......IMLS..KDPIPPIVGNSGNLAI.AYMDVFRP----KVPIhVAMTGA..L--N..ACGEIEKVSFrstKLATAHRLGLRLAG--PGAFDVNTGPNWATFIK................
#=GR POLS_IBDVB/454-722        pAS   .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
POLS_DXV96/444-702                   ..........VAVPLAATLAPQFAPIIGAADGLANAILGD..---SASGRPVGNS.ASGM................PISMSRRLRNAYSADSP............................................................................................LGEEHWLPNENENFNKFDIi.....ydVSHS.S...MALFPVIMME.HDKVIPSDPEELYIAVslTESLRKQI--PNLNDMPYYEMGGHRVYNSVS....S.N.V.........RSGNF.LRS......DYILLPCYQL.L..EGR......LASS..TSP-NKVTGTSHQLAIyAADDLLKSGVLGKAPF.AAFTGS..VVGS..SVGEVFGINL...KLQLTDSLGIPLLGNSPGLVQVKTLTSLDKKIK................
#=GR POLS_DXV96/444-702        pAS   .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
Q2PBR5_9VIRU/467-809                 ........ti--APIAGAVFPAAAPLTSAISTMANAASGR..-ALAASGKPLYRNmALAG................ERPLSRQITRIARTAARmtatalrsaaltpcclrnqdacnltadilmeltgadscppgissaarlvnenngcrcsnpspdikdaisaieageamdsiltaevaqaadrpM------IRTKRKARKTRTa.....ngVELSaV...GVLLPVLMDS.-GRRI---SGGAFMAV..KGDLSEHIKNPKNTR-IAQTVAGGTIYGLSE....MvN.I.........DEAEK.LPIk....gAITVLPVVQA.T..ATS......ILVP..DNQ-PQLAFNSWEAAA.CAADTLES---QQTPF.LMVTGA..VESG.nLSPNLLAVQK...QLLVAKPAGIGLAANSDRALKVVTLEQLR----qvv.............
#=GR Q2PBR5_9VIRU/467-809      sAS   .................................................................................................................................................................................................................................................................................................................................................................*..............................................*....................................................
D0U495_9VIRU/434-694                 vpaasdwanr--------MLPGSGDVIKGINRTAGHLLYG..--EAASGRLIAQS.ASGSligqlghrdalacdvdP---------------Tlmgh...................................................................................naaqlICYNTALGVRSTGNRIYMIrl...ktpKRNP.R...VTIFPALVFN.TTPLGPEVSGTQLYAV..IEGLYNQV--PQ-SRFKVTGKNGRTIYGIKP....G.A.Y.........IPPGP.N--......-CTVVPISSI.T..QNE......ITTT..ATP-PIPRGGSMEAAL.ALLQYIPP----GVTP.FAVTGN..VIEG..KIVPNKWADL...KREGMKGTGIPLVTD------------------qdyktikdlakateml
#=GR D0U495_9VIRU/434-694      pAS   .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
POLS_IBDVU/454-722                   ..........IAVPVVSTLFPPAAPLAHAIGEGVDYLLGD..EAQAASG--TARA.ASGK................ARAASGRIRQLTLAADKgyevvanlfq........................................................................vpqnpvvdgiLAS----PGILRGAHNLDC........VLRE.G...ATLFPVVITTvEDAMTPKALNSKMFAV..IEGVREDLQPPSQRGSFIRTLSGHRVYGYAP....D.G.V.........LPLET.GRV......-YTVVPIDGV.W..DDS......IMLS..KDPIPPIVGSSGNLAI.AYMDVFRP----KVPIhVAMTGA..L--N..AYGEIENVSFrstKLATAHRLGLKLAG--PGAFDVNTGSNWATFIK................
#=GR POLS_IBDVU/454-722        pAS   .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
A0A4P8PKK9_9VIRU/585-764             ptkftthrga------------------------------..-------------.----................-----------------............................................................................................-------------------........----.-...--LFPTVAFG.EGTSV----AQTYV-A..LPGDYRHLMAPNLRNEWAPTQDGFKVYGMTHhtihD.N.G.........KPSRK.LNIqvatggNITILPVDKVqW..DKEdpglatVTTS..WNGFPAVVGQSGSLAL.ALASNL-----DYFPQ.AVFTGC..LNNG..QVQPVAFGCM...KAQAAHALGLKLCGFTTGRD-------------ediplyt.........
#=GR A0A4P8PKK9_9VIRU/585-764  pAS   .................................................................................................................................................................................................................................................................................................................................................................*..................................................*................................................
#=GC seq_cons                        ...........ssPlhuTlhP.uAPLhsAhsthusthlGs.....AASGp.hupu.ASGp................shshStpl+phh.sss.............................................................................................l.p....sshpps.p.h.h........l..p.s...hsLFPVlhhs.psp.sPttstsphhAV..ltuhhccl.sPs.ps.hhhThsG++VYGhsp....s.s.h.........lshph.sp.......shTlLPltpl.h..ssp......lsls..csshP.lsGsSspLAl.Ahhshlhs...ttlPh.sshTGs..l.ss..slhsltslsh...KttsA+phGLsLhGs.sGh..............................
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