#=GF ID   Bombinin
#=GF AC   PF05298.15
#=GF DE   Bombinin
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_5347 (release 7.7)
#=GF GA   21.40 21.40;
#=GF TC   21.40 22.20;
#=GF NC   21.30 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Bombinin
#=GF RN   [1]
#=GF RM   11835991
#=GF RT   Antimicrobial peptides from skin secretions of Chinese red belly
#=GF RT   toad Bombina maxima. 
#=GF RA   Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang
#=GF RA   Y; 
#=GF RL   Peptides 2002;23:427-435.
#=GF DR   INTERPRO; IPR007962;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of Bombinin and Maximin proteins from
#=GF CC   Bombina maxima (Chinese red belly toad). Two groups of
#=GF CC   antimicrobial peptides have been isolated from skin secretions
#=GF CC   of Bombina maxima. Peptides in the first group, named maximins
#=GF CC   1, 2, 3, 4 and 5, are structurally related to bombinin-like
#=GF CC   peptides (BLPs). Unlike BLPs, sequence variations in maximins
#=GF CC   occurred all through the molecules. In addition to the potent
#=GF CC   antimicrobial activity, cytotoxicity against tumour cells and
#=GF CC   spermicidal action of maximins, maximin 3 possessed a
#=GF CC   significant anti-HIV activity. Maximins 1 and 3 have been found
#=GF CC   to be toxic to mice. Peptides in the second group, termed
#=GF CC   maximins H1, H2, H3 and H4, are homologous with bombinin H
#=GF CC   peptides [1].
#=GF SQ   2
#=GS A0A834LZX5_RHOSS/20-135  AC A0A834LZX5.1
#=GS A0A6A4M0Y8_9ERIC/18-135  AC A0A6A4M0Y8.1
A0A834LZX5_RHOSS/20-135             aekcrqlvgeeassksrterftflnc-------------------------------------------------LDMSY...GTIACAVKEIVKLYFYYIRAAHVHkEVSEATEAAMREKLSEGHS.LEEAVRWAYQ-KGNEAKRRATRQAKHIMGPVISS----------awdffeti
A0A6A4M0Y8_9ERIC/18-135             ....................itaekc------------------------------RQLVGEEASSKSRTDGFTFLNCFDmsyGTIACAVKEIVKLYFYYIRAAHVHkEVSEATEAAMREKLSEGHSlEEAVKWAYQ--KGNEAKRRATRQAKHIMGPVISS----------awdffeti
#=GC seq_cons                       ....................hTh.pC.................................................Lsh.....GTIACAVKEIVKLYFYYIRAAHVHKEVSEATEAAMREKLSEGHS..Etshhhh...KGNEAKRRATRQAKHIMGPVISS..........AWDFFETI
//