#=GF ID   Bse634I
#=GF AC   PF07832.15
#=GF DE   Cfr10I/Bse634I restriction endonuclease
#=GF AU   Fenech M;0000-0001-7933-4617
#=GF SE   Pfam-B_46671 (release 14.0)
#=GF GA   27.00 27.00;
#=GF TC   42.50 42.40;
#=GF NC   23.10 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF WK   Cfr10I/Bse634I
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   11842098
#=GF RT   Crystal structure of the Bse634I restriction endonuclease:
#=GF RT   comparison of two enzymes recognizing the same DNA sequence. 
#=GF RA   Grazulis S, Deibert M, Rimseliene R, Skirgaila R, Sasnauskas G,
#=GF RA   Lagunavicius A, Repin V, Urbanke C, Huber R, Siksnys V; 
#=GF RL   Nucleic Acids Res 2002;30:876-885.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR012415;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Cfr10I (Swiss:P56200) and Bse634I (Swiss:Q8RT53) are two Type II
#=GF CC   restriction endonucleases. They exhibit a conserved  tetrameric
#=GF CC   architecture that is of functional importance, wherein two
#=GF CC   dimers are arranged 'back-to-back' with their  putative
#=GF CC   DNA-binding clefts facing opposite directions.  These clefts are
#=GF CC   formed between two monomers that interact, mainly via
#=GF CC   hydrophobic interactions supported by a few hydrogen bonds, to
#=GF CC   form a U-shaped dimer. Each monomer is folded to form a compact
#=GF CC   alpha-beta structure, whose core is made up of a five-stranded
#=GF CC   mixed beta-sheet.The monomer may be split into  separate
#=GF CC   N-terminal and C-terminal subdomains at a hinge located in helix
#=GF CC   alpha3 [1].
#=GF SQ   20
#=GS A0A1W1Y134_9NEIS/43-332  AC A0A1W1Y134.1
#=GS A0A2N5WTU4_9ACTN/8-291   AC A0A2N5WTU4.1
#=GS A0A2T0ZTG7_9ACTN/49-330  AC A0A2T0ZTG7.1
#=GS A0A4Q7XFT9_9ACTN/49-332  AC A0A4Q7XFT9.1
#=GS A0A1J1LCN2_9CYAN/8-319   AC A0A1J1LCN2.1
#=GS A0A2A2T9U1_9CYAN/25-149  AC A0A2A2T9U1.1
#=GS A0A6H1U5M1_9CYAN/1-293   AC A0A6H1U5M1.1
#=GS K9RTS0_SYNP3/10-273      AC K9RTS0.1
#=GS A0A7X1FWE7_9SPHN/21-289  AC A0A7X1FWE7.1
#=GS A0A2S3QD22_9FIRM/12-289  AC A0A2S3QD22.1
#=GS A0ZMH7_NODSP/2-291       AC A0ZMH7.1
#=GS A0A2A2TA74_9CYAN/1-57    AC A0A2A2TA74.1
#=GS A0A133UXA0_9EURY/2-258   AC A0A133UXA0.1
#=GS F4KRY3_HALH1/15-278      AC F4KRY3.1
#=GS A0A432WYT0_9GAMM/35-285  AC A0A432WYT0.1
#=GS A0A852SMY0_9MICO/3-269   AC A0A852SMY0.1
#=GS K9VYZ4_9CYAN/2-290       AC K9VYZ4.1
#=GS A0A7H0H471_9ACTN/42-323  AC A0A7H0H471.1
#=GS A0A843B539_9BURK/19-287  AC A0A843B539.1
#=GS A0A1W1VRH5_9THEO/33-318  AC A0A1W1VRH5.1
A0A1W1Y134_9NEIS/43-332             mnctfdsfmpgcdndpepdrsfseylaqfqsnalnagealfpgdldi---------.-..--------.--.--------------------------SRPAIAKVEGdvFE.LLEAGAFWNAAVAWNNFMDSgq...wnSKVFSCPVNavPTP..A...RKV..GIVKLPR--................................GYDATLLFKEDVRK.HIKFHEVAL..ARNETKLGLSSPDIVGVRLP.HPLPF.....sMQEFLN...PVDDLG..KENLA...LLQGAHTMLEGRIDSSGFLFAVAVKRTTRSDRMYQPLFEANVLKYLiGEVLRGpAF.......RFYAHLNS...FDGADV..RETYK..AASLLSLIKGGAGGARAIDALYLAQKPRDSAQ--------silndlt...........
A0A2N5WTU4_9ACTN/8-291              .............................................sf---VPGFAE.A..GVNGMPYG.--.QIIDRPIENAKKEGQLLYG--VDFSVSPAAVAKVAGdiFE.IISSAVLWNAAARWNFYMRTgsw.vsaPRYAKPNTQ..PAP..S...RQV..AVLNLPR--................................DYDWVQLLVPEARD.KIEEIRAGL..GGKELGLPTSTPDLAVVVVP.EELRE......LDLWAD...GLPDLK..HPSQA...ELRHAHKLVEGRVEPGEIILAVAFKKSLRSDRLYQPLYEANVMQLL.LEGRLG.AP.......RVEFEVHT...LSLEGT..DALNTytAASLYAVAEDRPDIHRAVRELYIPETATHLVKRFLGFLNE..................
A0A2T0ZTG7_9ACTN/49-330             ......................................aalpgwgss---------.-..---GLNAM.PFqEVVRQPIANARAEGDYLYG--SDFTLDSNAIAKVTGdiYE.TLTSAILWDAAAYWNSFMATgnw.ptpRRYARPSVG..RSE..R...RQV..GIVNLPR--................................RYDWVRLLEPNAKA.RIAVLRDKL..AENNLSMPTSTPDIAVVVLP.DEVRK......DDIWRT...PFLNLD..RGSQG...TLSTAHTRLADSVEPGEIILAMALKSSLRSDRLYQPLYEANVMQLL.LERHLG.AP.......RVEFEVHA...LTAEGTgaTAIYT..AASLHSAGE--PTAHRAVRELYEPANATQIVQRFFAFLN-q.................
A0A4Q7XFT9_9ACTN/49-332             .............................................sf---IPGFAA.A..GINNMPYA.--.EIISRPLENAKDEGKLLYD--VDFSVSSSAEAKVAGdiFE.IVSSAVMWNAAAWWNRYMIGgaw.gvtPRYAKPKTQ..PSP..S...RQV..AVLNLPR--................................DYDWVQLLVPEARD.KISEIRNGL..GDKSLGLPTSTPDLAVVVVP.EELRG......LDLWST...PLPNLN..HPAQS...ELREAHKLVQGRIEPGEIILAVAFKKSLRSDRLYQPLYEANVMQLL.LEGRLG.AP.......RVEFEVHT...LAPEGT..DAFNTytAASLYAVAEDRPDIHRAVRELYIPATASDMVQRLFGFLNE..................
A0A1J1LCN2_9CYAN/8-319              ..........................................lkqet-------EK.D..TKYTIKGSeVY.QTLYPQIKDKIDKNESVIDILTWIEAEVKTAYNEAYkgSEiELTQGALNNCRGQWNEFLIT.......SFLAEIAID..FYS..T...HKLyfVPFRLARSGetnktvkkpksqkkgtsqetvsteetvsseaaS-KFLALFHKDEFK.ENKGLHHIN.qFKDNIFFSSPDYVLSIL---.DDQGL......FNQIQP...LLNQQA..NEAES...LGTEIYKLLQGKLKAQEVKAVLSVKISNRPDRRYQALYETAMIKAI.GYACGQ.NW.......KYYMVTAK..qASLSDV..KIFTK..GIAPHGIAIKREL--ISVDQVYSCSNKQDLIKLVEDAL--p.................
A0A2A2T9U1_9CYAN/25-149             .................................selfksfdirvrql---------.-..--------.--.------------------------------------..NA.NVTMGALNNAHGDWYEWLIG.......IAAWNYCID..NPG..S...-YL..-TIPLPNVT................................QFDIATLYKEDIKF.IIQELRDNV.eSRASVSLITSNPDFVII-NP.EKLDF......------...------..-----...----------------------------------------------.------.--.......--------...------..-----..----------------------------------------shdksnkithidiscins
A0A6H1U5M1_9CYAN/1-293              ..............................................m-NNQNWFSDrN..NQIQINTIeIY.KSLVDRIERKIQNNEQTANIVDWLVSETQRVFQKNY..NR.IPTQGALNNSIGRWNEFIAL.......TLFTKSVID..YNQ..KhpdSYV..VVFKLPNTKisrq........................nltpS-KFLQLFHKQEFE.KQGKLA-KLspFKEKIFFPS--PDFIIVNLD.GQSHLllgnnyKSELTQ...LLQQQS..REPNE...N--KIFPFLQGKMLASHLKSAISLKTSNRPDRRYQPLFEAAMIKAM.SSATHQ.QW.......RYYMVASE...FTETDQ..ILFEK..AIAPHGIAIQKES--KFVDNIYLNLNKNNFHGL-------iddsms............
K9RTS0_SYNP3/10-273                 ......................ymiqvfcslrsgnfpnqndtfrgil---------.-..--------.--.--------------------------DSLDQAARAI..NP.SVSQGSLNVCHGDWYEWIIA.......RSLWNFRIQ..NRK..K...-LI..-GLLLPKVS................................SFDISNLYTPNLSN.HINDLKQKV.nNIAGVQLITSNPDFVVI-DP.EEIDV......DPSLNS...HIHQFT..SDSIR...LLQQSYTGFIDQCSFNNIVAYLAVKTSFRSDRRLQIPHEGSLMKATyIHLQTR.EWvinpkglKYYAAASE...VGPADR..DALKT..-VATHSITNVQSLPQAAVDEVFEINTLQQANDAFEKIL--i.................
A0A7X1FWE7_9SPHN/21-289             ...................afkdyrqqayrntreagallwpgafrls---------.-..--------.--.---------------------------EQQLAKVDGdvYE.MMEAAALWNAAATWNKFMDTglwdssvFRKPDGAV-..PTP..T...RKV..AIVKMAR--................................GADTTKLLSPAARA.EYFAFETAL..QKRGLELKLSTPDILGLRIP.DPMPA.....gFEIFMS...PLPDLT..LASQE...QLETAWRGIQGSLEGRHFLFAIAVKTSTRSDRLYQALFEANVLKYIlGYVLRG.-Pa.....iRFHAHLET...FANADV..VGRYK..AASMTSLLA-GGVPSKAVDQLYLALNPRDTAQMIL-----delp..............
A0A2S3QD22_9FIRM/12-289             .........................nsatgkgqivpshalddlygas---------.-..--------.--.----------LPQL-PIVATLEQLTKHISDVANAKG..LA.LPSREALSNARGTWFETLVV.......ASAWNYIIN..LGI..T...DTL..-VVQLPNVQ................................RFDFRNLFDQSSQS.MLDDLERSLrrHEVDVEMVTSNPDLIVI---.-KSKDm....lSRLAPR...KIANLS..LANQH...YLSGFYENLRTKCPWDSIVAGIGLKTSVRPDRRLQLVHEGNILKSTfAHLKMR.HWnrd.frfLYVVASSE..kFNDADK..KALKT..-AATHTIVNVDATPERSVDELYWLTEFEDVERMLGDVIT-t.................
A0ZMH7_NODSP/2-291                  ...............................................FNNTEWLTE.NsnGKFRINSRaIY.RDLSSKIVNKLDQNLSVSEILDWMRNETSKAFREKY..SQ.NPQVGALNKATGGWNELMAT.......SLLSEIVLN..INQ..E...NEVciAVFSMPNSRpqieg......................vdqsyS-SFLNLFKNEYFA.NINNASAKIkpFKDNIFMPSPDDIIAVI---.EDEKN......SKIVNS...LLEQQA..RDPDT...L--ALYNSFKGKLGIKEVKAAISLKTSNRPDRRYQPLFEAAMVKAM.GYVLQQ.IW.......KYFMVVSE...LTPADR..TIFST..AIAPHGVALEKNL--KLVDGTYLYSRKADLLPLVNDAIKK..................
A0A2A2TA74_9CYAN/1-57               ...............................................---------.-..--------.--.------------------------------------..--.--------------------.......---------..---..-...---..---------................................--------------.---------..--------------------.-----......------...------..-----...----------------------------------------------.------.--.......-YYAISTK...VGEADR..KALRT..-VATHSIANIDSQPQAAVDSVHSVNSLAEAIVVFDEILKS..................
A0A133UXA0_9EURY/2-258              .................................elnqwgnpgiktee---------.-..--------.AF.FYLKDKID----FDNPISKILEKIEQEIKEISRELL..GE.EPTGNSLRRSRGDWFELIVF.......EAVWEA-IP..PNN..N...-FV..-AIKLPRARv..............................gSGGYLGNFR----E.--SEVKDNL..IKK--NLYCSNPDFMVFKES.EENGSg....wKDMSLR...KIWGDK..S----...------KEISGTIKMENVFSIIAAKTNPRPDRRYQHLHEATTTKTI.HKLADK.PKg....giKYHTVMMK...MGEKDK..EVYTY..-PFIYNMIVNGSV-KPVIDSYLVSESYTDILEFFRKIFNK..................
F4KRY3_HALH1/15-278                 ........................qkniafctllggllpdddilitd---------.-..--------.--.-----------------------LFNHFDNKVREQE..-K.SISREALSNVHGDWYEWLLA.......IAAWNYTAE..-NP..N...ANL..-ALLLPNVI................................QFDVSTLYVERLNK.LIDDLRNKV.iTVSGVQLITSNPDFVIV--N.RDL--......VNQYFG...NIEPIT..KISTTslsNLETMYQRFINKCDYEQIEGYISVKTSLRPDRRLQIPHEGSLMKALyAHLQTR.EWitnpkglKYYAIATR...MTPPDR..SALKT..-VATHSLTTVFSLPQAAVDNVFEVNSLKQAKQAFSSIL--v.................
A0A432WYT0_9GAMM/35-285             ...............................vyhapdlkimdaftqi---------.-..--------.--.----------------------------DSVAMNAG..--.-LERGALNNARGDWYEWIIG.......ANAWNYRIK..KQS..P...-LL..-ILNLPNKK................................RFDVSKLYQDKFSD.QIADLRQKV.sESSDVELITSNPDFVII---.-DTSNi...elPHRFHI...PFGRLT..VDDLD...LLDTAYQDFIGQCSFDDIRGYFSVKTTFRPDRRLQIPHEGSLMKAIhVHLQTR.SWiidpkalKYYAAATK...VNNSDR..EALKT..-VATHSITNVSSKPQAAVDDVFVIDSVEQLHDALEVIL--ei................
A0A852SMY0_9MICO/3-269              ...................frevvqqpvenahaegqllygsdyvfap---------.-..--------.--.----------------------------NAASKVAGdiYE.LITSAVLWETAAAWNRVMRGqaw.ptsPRYARPQVR..ASD..G...RQI..AVLNLPR--................................RYDWVKLLVPSAQQ.EITNLRARL..GTHGLGMPTSTPDVAVVVLP.ETERQ......APVWAQ...SLGNMS..LASQR...TLEGAHRVLEGKIEPGEIVLAIALKTSLRSDRLYQPLYEANVMEFL.LEGHLG.AP.......RVDFEVHT...LSAEGT..GALNTysAAALSSAAS--DHPHRAIRELYVPANAAQVVQRFIGFLNE..................
K9VYZ4_9CYAN/2-290                  ..............................................v-NNIEWFTK.KdgDKVQINSRiIY.RNLSTELVNKLDNNLSVNEIISWIKNTTREAFREQY..AR.YPEVGALNNAAGRWNEFIAT.......TLLSEIAFD..INQktD...ECI..AVFSLPDSRlqke.......................dsdevSSKFLSLFSKDEFD.TGKALAK-ItpFKNNIFLPSPDYVIVVL---.---AN......SDIVTSvqcLLAQQA..KAPDT...L--ALYNFLKGKIQVGELKAAVSLKTSNRSDRRYQPLFEAAMIKSM.GYLLDQ.PW.......KYYMVAST...LTPADK..SIFSK..AISPHSMALEQNA--KLVDGTYLYNRKSNLEPLVQAAIE-n.................
A0A7H0H471_9ACTN/42-323             .............................................ag---IPGWTS.S..GLNSMSFR.--.EVVLQALGNANDEG-RLWYG-ADYVVKANAVSKVTGdiYE.IVTSAVLWETAAAWNRYMRGdaw.rtsPRYARPQVT..PSL..N...RQV..AVLNLPR--................................RYDWVKLLTPEAQE.RVREFRASL..ASNDLAMPTSTPDIAIVILP.ASEQQ......SPVWTA...DLGDLS..LPSQR...RLDDAHRTLEGKIEPGELILAIALKTSLRSDRLYQPLYEANVMEFL.LERYLG.AP.......RVEFEVHT...LTAEGT..GAAIT.ySAAALSSAGG-DDPHRAIRELYVPANAGQVVQRFIGFLN-e.................
A0A843B539_9BURK/19-287             ..................................nrsfeeylgtfrn---------.-..--------.--.--------NALAAGNLLFG--SAFDVKSSAIAKVEGdvFE.LLEAGAFWSAASAWNKYMDSgdw.istAFTCPAGSV..PTP..T...RKV..AIVKLPR--................................GYDATKLFRPEVRG.SIQAHEHAL..KLRGMELGLSSPDIVGVRLP.HPLPA.....eLQIFMQ...PVASLG..EADQL...LLEDAHKLLEDRIEATGFLFAVAVKRTTRSDRLYQPLFEANVLKYLiENVLRG.AA......fRFYAHLNS...FAGADV..EGHYR..AASLISLIRG-GTPTKAVDVLYLAT---------------hprasaqsildd......
A0A1W1VRH5_9THEO/33-318             ...........................kcllkylsqkplselvgkvt---------.-..--------.--.-----------------SDLLDELQNGIKKASQKHY..GI.EPRDQSFNNVRGAWFEKVVSfw...lwSRWYEYCKN..IGG..I...PYF..-VLKLPDAA................................KFNFVKIFCSEEEEkVIGSLKKHL..DNHGVALETSNPDFVVVTLKaGEHKScp.vkhKDFSLE...NLGRLEdlYRNFE...YLENLYRGFRNKCKYTDVICAIGVKDSLRPDRRLQLVYEGNIFKAVmLHFKTR.FWdysyeipPFYAIVNGkkaPGKKDA..RALIT..-ATTSTLVDIRLRPERAVDETFYAGRLGDIDQVFSKI---ker...............
#=GC seq_cons                       ..........................................hhht.................................................h..p.pshu+hth..hc..losuuL.NutusWNcahhs.......sthhchsls...ss..s...ppl..sllpLPc..................................paDaspLap.chpp.pIpsl+ppL..tppsltLsoSsPDlsll..s.cc.pt.......shhhp....lsphs..psspp...hLpshaphlpG+lchsclhhAlulKoShRsDRhYQsLaEAslhKhl.hchttt.th.......+aahhssp...hsssDp..puhpT..usuhaolsp.tstsp+AVDplYlssshpphhphh.thl....................
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