#=GF ID CATRA-C
#=GF AC PF20270.2
#=GF DE CASPASE and TPR Repeat-Associated C-terminal domain
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Aravind L
#=GF GA 24.60 24.60;
#=GF TC 25.10 25.80;
#=GF NC 24.50 24.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 32868406
#=GF RT Identification of Uncharacterized Components of Prokaryotic
#=GF RT Immune Systems and Their Diverse Eukaryotic Reformulations.
#=GF RA Burroughs AM, Aravind L;
#=GF RL J Bacteriol. 2020; [Epub ahead of print]
#=GF DR INTERPRO; IPR046923;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC One of two constant domains forming the CATRA module which is in
#=GF CC turn C-terminally fused to a diverse range of conflict effector
#=GF CC domains. This gene, along with a gene encoding the CATASP domain
#=GF CC and a gene encoding a TPR repeat region fused to a CASPASE
#=GF CC domain, forms the three gene island making up the CATRA conflict
#=GF CC systems. This all alpha-helical domain is predicted to be
#=GF CC involved in recognition of invasive molecules or in the
#=GF CC transmitting of a signal through conformational change, enabling
#=GF CC CASPASE-mediated proteolysis to free the fused effector domains.
#=GF SQ 80
#=GS A0A1X7C7J5_9ACTN/229-350 AC A0A1X7C7J5.1
#=GS A0A7X0IC25_9ACTN/227-354 AC A0A7X0IC25.1
#=GS A0A841C463_9ACTN/195-317 AC A0A841C463.1
#=GS A0A7K2YF25_9ACTN/205-354 AC A0A7K2YF25.1
#=GS A0A4U3MG16_9ACTN/238-302 AC A0A4U3MG16.1
#=GS A0A7W5YUH3_9ACTN/196-325 AC A0A7W5YUH3.1
#=GS A0A545APA1_9ACTN/225-346 AC A0A545APA1.1
#=GS A0A162J0A8_9ACTN/214-379 AC A0A162J0A8.1
#=GS K0K976_SACES/198-315 AC K0K976.1
#=GS A0A5M3VZH2_9ACTN/246-378 AC A0A5M3VZH2.1
#=GS A0A1S1QG02_9ACTN/221-364 AC A0A1S1QG02.1
#=GS A0A3N2PBA6_9ACTN/207-341 AC A0A3N2PBA6.1
#=GS A0A4R6J9T8_9ACTN/212-332 AC A0A4R6J9T8.1
#=GS A0A4R4P2T3_9ACTN/213-348 AC A0A4R4P2T3.1
#=GS A0A1G7XEC5_PSEOR/217-352 AC A0A1G7XEC5.1
#=GS A0A010YLS5_9ACTN/176-281 AC A0A010YLS5.1
#=GS A0A841D6H7_PLAVE/199-337 AC A0A841D6H7.1
#=GS A0A1I0BYY8_9ACTN/254-380 AC A0A1I0BYY8.1
#=GS A0A2T0RCI2_9ACTN/309-347 AC A0A2T0RCI2.1
#=GS A0A2S6GT20_9PSEU/205-317 AC A0A2S6GT20.1
#=GS A0A1G7XDB7_PSEOR/211-336 AC A0A1G7XDB7.1
#=GS A0A841BUK7_9ACTN/225-361 AC A0A841BUK7.1
#=GS A0A8J3MII1_9ACTN/221-357 AC A0A8J3MII1.1
#=GS A0A1S1QF37_9ACTN/320-458 AC A0A1S1QF37.1
#=GS A0A810NDN0_9ACTN/244-367 AC A0A810NDN0.1
#=GS A0A2B8AVU4_9ACTN/221-355 AC A0A2B8AVU4.1
#=GS A0A6F8YXY0_9ACTN/318-358 AC A0A6F8YXY0.1
#=GS A0A429FKE3_9ACTN/234-340 AC A0A429FKE3.1
#=GS D3D729_9ACTN/221-345 AC D3D729.1
#=GS A0A239ISV6_9ACTN/228-371 AC A0A239ISV6.1
#=GS A0A840NXD4_9ACTN/218-354 AC A0A840NXD4.1
#=GS A0A0D0VYV8_9ACTN/234-372 AC A0A0D0VYV8.1
#=GS H2JYC8_STRHJ/233-378 AC H2JYC8.1
#=GS A0A7M2T6A0_STRCW/235-379 AC A0A7M2T6A0.1
#=GS A0A7K1KXJ2_9ACTN/1-42 AC A0A7K1KXJ2.1
#=GS A0A428YTD4_9ACTN/214-345 AC A0A428YTD4.1
#=GS A0A4U3MG16_9ACTN/209-245 AC A0A4U3MG16.1
#=GS A0A1C4RG02_9ACTN/221-356 AC A0A1C4RG02.1
#=GS A0A1S1QFF2_9ACTN/256-402 AC A0A1S1QFF2.1
#=GS A0A2T0STI2_9PSEU/206-321 AC A0A2T0STI2.1
#=GS A0A6F8YXY0_9ACTN/343-425 AC A0A6F8YXY0.1
#=GS A0A8J4DVC9_9ACTN/214-349 AC A0A8J4DVC9.1
#=GS A0A543C0Q5_9ACTN/226-314 AC A0A543C0Q5.1
#=GS A0A4R1DVC6_9ACTN/221-356 AC A0A4R1DVC6.1
#=GS A0A7W7MCH4_9ACTN/219-339 AC A0A7W7MCH4.1
#=GS A0A6F8XR89_9ACTN/285-322 AC A0A6F8XR89.1
#=GS A0A2I2KP68_9ACTN/247-374 AC A0A2I2KP68.1
#=GS A0A810NBD0_9ACTN/181-322 AC A0A810NBD0.1
#=GS A0A0M8UWR4_9ACTN/220-356 AC A0A0M8UWR4.1
#=GS K0K3J1_SACES/205-337 AC K0K3J1.1
#=GS A0A6M1L7X5_9ACTN/196-340 AC A0A6M1L7X5.1
#=GS A0A516RIQ3_STRST/209-353 AC A0A516RIQ3.1
#=GS F8AYB9_9ACTN/247-391 AC F8AYB9.1
#=GS A0A1H1Y8E9_9ACTN/208-313 AC A0A1H1Y8E9.1
#=GS A0A1H9JCD7_9ACTN/233-371 AC A0A1H9JCD7.1
#=GS A0A4R1HJ22_PSEEN/222-350 AC A0A4R1HJ22.1
#=GS A0A5M3WCM8_9ACTN/223-347 AC A0A5M3WCM8.1
#=GS W7ST62_9PSEU/209-326 AC W7ST62.1
#=GS A0A2T0RCI2_9ACTN/332-414 AC A0A2T0RCI2.1
#=GS A0A4R2JHB5_9PSEU/219-337 AC A0A4R2JHB5.1
#=GS C7PYD3_CATAD/241-366 AC C7PYD3.1
#=GS A0A5M3XYX8_9ACTN/126-253 AC A0A5M3XYX8.1
#=GS A0A8J4DSW8_9ACTN/210-238 AC A0A8J4DSW8.1
#=GS A0A1I2JCC6_9ACTN/261-401 AC A0A1I2JCC6.1
#=GS A0A4R4XPL7_9ACTN/187-306 AC A0A4R4XPL7.1
#=GS A0A1V9KGZ6_9ACTN/215-354 AC A0A1V9KGZ6.1
#=GS A0A7K1KTA6_9ACTN/203-331 AC A0A7K1KTA6.1
#=GS A0A6G2B5T9_9ACTN/233-370 AC A0A6G2B5T9.1
#=GS A0A6F8XR89_9ACTN/313-392 AC A0A6F8XR89.1
#=GS A0A1S1R1R4_9ACTN/211-351 AC A0A1S1R1R4.1
#=GS A0A8J3HP52_9ACTN/222-358 AC A0A8J3HP52.1
#=GS A0A4U3MJM4_9ACTN/207-275 AC A0A4U3MJM4.1
#=GS C7PYD7_CATAD/230-405 AC C7PYD7.1
#=GS A0A8J4DSW8_9ACTN/234-291 AC A0A8J4DSW8.1
#=GS A0A4U3MJM4_9ACTN/176-213 AC A0A4U3MJM4.1
#=GS A0A4R6RRX8_LABRH/215-331 AC A0A4R6RRX8.1
#=GS A0A1Y5YAA2_KIBAR/215-331 AC A0A1Y5YAA2.1
#=GS A0A7W9DQK5_9ACTN/224-349 AC A0A7W9DQK5.1
#=GS A0A7W7WRP1_9ACTN/208-342 AC A0A7W7WRP1.1
#=GS A0A438M8U0_9ACTN/187-306 AC A0A438M8U0.1
A0A1X7C7J5_9ACTN/229-350 ....................PPLARYLMHAAKLR..YQARVWGEG..EPRLRRLIGRVNEHVAQVRDAL.....E..----------.......RETDDPAALGRLRLDEADLASAVRDIRAIRRTVEIAAHNMSAA..VA---..........................................--....EPWRG.DRRLAEWLVGQLDDDTEYVEAARELA........
A0A7X0IC25_9ACTN/227-354 ....................PPLARYLLHAAVMR..FHLRVWQRD..-DRTAESRDAIDALLADLRRRR.....A..TARGGGRPLD.......--------LSRLGLYD--ASLICADLRELRESVTISVHNMSRV..VGTPQl........................................lAA....GPFAD.DRAMARSFIARLDDQIAYLEIAAHR-t.......
A0A841C463_9ACTN/195-317 ....................PPLARYLLHAAKIS..YHARVWSAD..R-SAEDARRRTDQAVAELLAVV.....A..--QPGRG---.......---DHSAALRTLQAARVDLSVALSRLREMQASVEIIRDNMRRY..LPD--..........................................--....-PLPA.DTRLADWLTQQLADAAGYLDLSRQRA........
A0A7K2YF25_9ACTN/205-354 ....................PPLAHYLLHAGRLR..HQLRVWRAA..HPGLWRLRQETDACLRELLRVV.....P..PARHQPSERI.......PGTSAARLLDDLQARVLALIDRSTRLREMRRTVEIVADNLRVL..DPSEEgssapp.............................pasgvarPV....GPFAD.DRALAEWFGRQLDDDAIYLEHTLQRC........
A0A4U3MG16_9ACTN/238-302 ................hrrr--------------..---------..----------------------.....-..----------.......-----------------------LDLAELRQTVEIVADTMRRS..LLASGl.......................................tvPG....GPFAD.DLDLAGWLLARLGDEIAYRSVDAERA........
A0A7W5YUH3_9ACTN/196-325 ....................PPLTLHLLHAAKVR..HQLRQRDRF..--DADEVLRRADETLRERHRAS.....-..----SDDPAE.......RLLEVRRRLSGLLSGPDGLTWATTLLREMERTVRIAEANLRPS..TRLAA..........................................TP....GPFRD.DLELAAWLGQRLDDDLLYLEAARERV........
A0A545APA1_9ACTN/225-346 ....................PPLARYLMHAAKLR..FHSRVRG-D..GSALTDLRRRVETRVGRLTDGL.....S..-----R----.......PDADLRDEAADLVRDEAILRATQAELRNMRRSVEIAEDNMRNA..ID---..........................................--....DLLPS.DARLVRWLKPQLGDDIEFVNIAREQA........
A0A162J0A8_9ACTN/214-379 ....................APFTRYLMHAAKLR..YHLRVWS-G..GEPVRALRRDTDQVLAELTALL.....A.aGGATGAGGPAdaagvtaLPAKITACAAALRRETGLLATTATQLKEIRRSVDLATSNMAAY..ADPGIaravrapagqp....................gvsgsgqpwprPG....GVFTD.DLALAKWFGNQLDDDHFYVTAALERA........
K0K976_SACES/198-315 ....................PPLGVYLLQCSTVV..HNLRVWQAF..RGRLDALRASADTAATTLRH--.....-..----------.......DPHDTAA-ATRVADVERALGFSEAKARDMAAAVRFALADLQGT..PGP--..........................................--....SPRGD.VVD-TERFLLALEEAVTTLANARRLA........
A0A5M3VZH2_9ACTN/246-378 ....................PPFAAYLLAVAKVG..YELRVHKPF..--DLRELRGQADNAVDRGLTAL.....R..EIDEGPDAQV.......DPEVSLRLLTGVLAGPKGLTQRHTRLTEMRRTVEIAMSTMARH..RDSEE..........................................--....GLFAD.DAELAAWFHQRLDDDLLYLGAARERV........
A0A1S1QG02_9ACTN/221-364 ....................TPFGYYLLQTAKIR..YLARLWD-D..GRRVRATRIALDATIVELSRLL.....A.eLAEPSVDGNRl....ddRRARARDLRLRSQAAVAALAVQSAEIGLLVHAVDIAASNAREA..LNAEApi......................................epSV....GLFGD.DAALSALFSCRLADERQYAERSAATA........
A0A3N2PBA6_9ACTN/207-341 ...................g-PFVHYLLDAAKLR..QQRRIYHAS..GSAIRQLRHGTDSAVDRLLALH.....-..--RTTPVAAA.......DLVTADIELTHLQVNSTGVITTHARLRKVARNADAVLGNLRRL..APLAP..........................................-Gw..qGPLAD.DQILGEALREQVSDDITELEIARDQA........
A0A4R6J9T8_9ACTN/212-332 ....................PPLGRYLMHAAKLR..YLVRVHDQG..-RDLARLQTEVANRIEEVTGLL.....R..-ANGRV----.......-----AGPAAALAAAEAELAGALAALRTMRRSAQIAFANMTGA..LG---..........................................--....HPLPA.DARLGPWLSDQLADDTEYLQATYEQ-v.......
A0A4R4P2T3_9ACTN/213-348 ....................PPLAGYLLNAARLR..FELRIWD-D..GEGTRRLREDTDTVVGRLLGTV.....T..ASAGRGHGEA.......ELIDASRELVSLQTRAMGLADRTARLREMARTVAIAAANLAAF..GGGTQ..........................................LG....GLFAD.DRALAEWFGRRLDDETAYLDAASQRA........
A0A1G7XEC5_PSEOR/217-352 ....................PALGRYLLNAARLR..HQLRLWGTT..RSRTMAARNAADARVDRLLGLL.....D..PATRGDPEVD.......ALLSASVEIVSLQAGKVGLARTAAGLREMRRTVEIATANLSAL..GGETT..........................................-L....GPFAD.DRALGAWFSQQLADDETYLDAAKDRA........
A0A010YLS5_9ACTN/176-281 ....................PPFARYLRHAASVR..YQLRAWQAA..-DEMRRVQERLDRGAPLAEARA.....-..----------.......-----------------DLAFWMAAVPDLDRNLEHAAADMRQV..PGVDP..........................................--....AVAED.DFGLIEWFRQGLADDLAHLRGVDDRA........
A0A841D6H7_PLAVE/199-337 ...................r-PFGRYLLHSAKMR..WAWWLILNE..-DRFRRVSVEVDTLTDRLAGLL.....HdaAARGGRVTTA.......ELAHGQAAVVSAVSGNAGLVTALRDLRTIRLSVKIAAENMRAA..IREDA.........................................aAG....TFLDH.DRRLSDRLAEQLDADIVYVEATRDSA........
A0A1I0BYY8_9ACTN/254-380 ....................PPLGRYLLHAAKLR..YELRVWERD..G-RTRELRGTLRDLSAEPHERR.....P..----------.......---ATSPGADLLTAHRLDAELMTVDLLELRRAVEIAADNMGRV..PFPCGpp......................................pgDA....GPFAD.DRDLAAWFMDRLDDEIAYLGLAARRA........
A0A2T0RCI2_9ACTN/309-347 ....................PPLARYLLDAAKVR..YELRVRQAE..DAALRRATTTG-----------.....-..----------.......-------------------------------------------..-----..........................................--....-----.--------------------------aegel...
A0A2S6GT20_9PSEU/205-317 ....................PPLARYLLHAGNLR..HHARVWDRE..RRSLAQLRGAVDTTASQARQGF.....S..----------.......-----ASVLARLRDLEAELLFCGTRARRMSRAVSTEAALMG--..-----..........................................--....VPLPG.DRGRADWLLAELSATIAALAESAALA........
A0A1G7XDB7_PSEOR/211-336 ....................PLLARYLIQAAKLR..YEARIVEAA..-DRLEPLRRAVTAAAAELRTQL.....G..---AGG----.......---SPAAALADLRLLDLRLRSSVRTLGALRRTAGIAATNMERL..TLSEE..........................................PT....GPFAE.DLAVARWLQDQLAVDLGYLDDTLAEA........
A0A841BUK7_9ACTN/225-361 ...................r--LPVYLLNSAKLR..HQARIIEQQ..RAEITQRRLSTYQQLNTIQALM.....-..-YASPTPDID.......QLVNAEVTITKMQAQSEGLVDTQARIATFQRTIGIAASNITTL..TDPVLd.......................................ptRR....SLVDD.DQALAQGISAALDDDHAFLAAVTTRA........
A0A8J3MII1_9ACTN/221-357 ....................PPLTRYLLQVAKVR..YESGVLQSR..LARLHLLMAQAAERCDELASLV.....-..--HRDELDLA.......GLREADGKLRELRVGRDGLVAALGDVRAMAGTVRIAQANMRAA..LEPGGr.......................................gsAA....GPLEN.DRQTVRWANHQLQVEQSYLSASLAQ-v.......
A0A1S1QF37_9ACTN/320-458 ....................PYLVGYLANAAKVR..YQYRVWSDA..-PSVAALRERAATDVTELRRRLm..spR..ADVASGADPA.......EAVLTDRLLVHLDL----LVAARADRDDMRESVEIAVSNIREM..LREDRs.......................................peDG...pGLFAE.DLRLATYLTEQLGRDRFFLTTAVDRV........
A0A810NDN0_9ACTN/244-367 ....................PPLARYLLHAAKAR..FQLRVLHRD..N-PSDDLRHRVDALAADVRA--.....-..----------.......-GDTSAAVIGALTAVQRDANLSVEDLRTMRHAVGVAKHNMAAAwgR--TP..........................................PDv..rGLFAD.DRDLIDWLLTHLDDEREHLETTAARA........
A0A2B8AVU4_9ACTN/221-355 ....................PPLAKYLLHAAKLR..YELRVWRAA..-EDIATLRAATDATIKAVLERT.....-..AVPAGPSRHT.......EIIRASHALVALQARERGLVDRSTLSREMARTVDIAAANLVLF..AGDES..........................................LG....GPFAD.DRALAGWLVQRLDDEAAYMESAVRRC........
A0A6F8YXY0_9ACTN/318-358 ....................APLPRYLLDAAKVR..YQLRVREAA..EA---SLRGALAGRATAA----.....-..----------.......-------------------------------------------..-----..........................................--....-----.--------------------------eta.....
A0A429FKE3_9ACTN/234-340 ....................PPLGRYLLHAAKLR..YELRVWNRD..G-DVRGLLAAVADGTAPAARA-.....-..----------.......-------------------RAAVAELRALRRTVEIADANMGRA..LDDPGa........................................fAA....GPFAD.DRDLARWLLEALDDASGYLEAAADRA........
D3D729_9ACTN/221-345 ....................PPLARYLLHAAALR..YQLRVWQRD..G-QSRQLHDTLDALGAELRR-L.....G..AQGQAQT---.......---------DVLRLRALDAVLAVSELRALRRSVDIIGDNLGRA..RELVEp........................................gIG....GPFAD.DADLARSLVERLDDQIAYLDAATESA........
A0A239ISV6_9ACTN/228-371 ...................r-PLTRYLMHAAKAG..YEARRYHTLasEKPLHKRRAASDQESRALLRAL.....Q.pGASGEPVSLK.......DVLAAAAMLDQTQLGPHGTLWAITQHRDLARTVNIAVTNMRLH..TPRLRr.......................................vgAG...pSWPER.DLAAAENLIAQVQNDVEYLSTARERA........
A0A840NXD4_9ACTN/218-354 ....................PALATYLLHLAKVR..YQYRVHAGE..-LGFLARGDALETDVARLVAL-.....-..HEDDEAVTPE.......RWRRAHQDLERVRVAAMDLALTAVGLAEMARTVEIAQDNARAV..LPHAAf.......................................spAG....GPLAD.DEDMIGWFRAQLEDDRVYVEAAVQRA........
A0A0D0VYV8_9ACTN/234-372 ...................a-TLTRYLLYAAMAR..YELRVWSAG..--QTRSLPHQVDARLARLLPLL.....D.eAAEEDQPDPA.......QWDRYARRLGRLVADEAGLLDAVAELSGLRRTVQIAATNMATL..VPSPAg.......................................ahRD....GPFAD.DHALTTWFDQQLDDDLTYLRATLAR-t.......
H2JYC8_STRHJ/233-378 ...................v-PLTRYLANAAIVRdqYGVRVADAAsiAGRLRGLRRQGAELTREWRDVLv..ahP.tGTRMGRRDLA.......RCESIAVRAQRLLAEERLAHAATGDMRLMLRNLEIAADGMKVL..GTGPD.........................................gTP....KTVGR.DKECHSNLAQILDDDVAHSEIAREQ-v.......
A0A7M2T6A0_STRCW/235-379 ....................APVTRYLLHAAIVR..HQYRVRRDA..HQRLGREQQGLQQEANRLLDDChrllgA.gSGRNSRRALA.......RWEKLAEAAQKLQITDRQAAVKDSLLRTMAQTVAIAADTMNGS.mI-EPG.........................................rPD...pRPLAA.DVQCAERLSEVLQDDAADVATTREL-v.......
A0A7K1KXJ2_9ACTN/1-42 ....................--------------..---------..----------------------.....-..----------.......---------------------------------------MTEV..LGVDG..........................................AG....RLFSD.DQALATWLGEQLKDDLEILEAARS--ht......
A0A428YTD4_9ACTN/214-345 ....................PPLPGYLWEMAKVR..HEARRFD-E..-RRSALVVPKLVERASRFEAAE.....-..-RSRGW----.......TGKARDEELRALQRDTALASAGAAALRTMQRTVQAASGDALAI..LEYAGr.......................................kpNG....GVFAA.DLAYVDWLRVEIADEADTAADAV---sya.....
A0A4U3MG16_9ACTN/209-245 ....................PPLARYLLSAARLR..HALRVWQEA..PETADHHRRRLD----------.....-..----------.......-------------------------------------------..-----..........................................--....-----.--------------------------la......
A0A1C4RG02_9ACTN/221-356 ....................APFLRCLEGAARLR..HHASVHRAH..QPALHSLCRRLSAASERLAGLC.....G..QVLAAGSGPD.......ELIAADASIAALYVGDQGLNQSLRDLRDMRQSVRITLDSLAEL..LPSAA..........................................--....GAGADpDQILGRSLLALIDDDIAHAESVKREA........
A0A1S1QFF2_9ACTN/256-402 ....................TPLGYYLLQAAKIR..YLNRLWD-D..GRRVRATRAVLDGITGSLARLL.....A.eAPRATAADAAaaq.vdeRADPANDLRRRSRAAAAVLVTQSAEIGDLAQAVDIATSNLAEA..RKAEVpv......................................dpSA....GLFGD.DVAMARLFAQSLADEHSYVERSLTR-s.......
A0A2T0STI2_9PSEU/206-321 ....................PPLGRYLLHASLLR..HHVRVWRRD..EPWLAGLREQVDGHVVESRD--.....-..----------.......---DPASAVDELRRDEIGLRVAGDRVERMRTSVETTRTNMAAL..EP---..........................................--....DLLPA.DVGLADWFLATLDDSLLGLTRGRAL-a.......
A0A6F8YXY0_9ACTN/343-425 ...............slrga--------------..---------..----------------------.....-..----------.......---------LAGRATAAETAVLLTRLADMRLTVEIARSNMDAV..LRALDpwg....................................gspTG....GLFAD.DRACAAWVQSRLADDVRYMRNAHRRA........
A0A8J4DVC9_9ACTN/214-349 ...................v-PLTRYLLHAAKLR..YQQWILVRD..LPAVRAATAAARTDCDRLVGDV.....-..---QRPMPPE.......RLRATSERLTLAQSRERGLVDSLSRIRIMTGTVRTAERNMRSA..LDTPTa.......................................dePG....SPLDN.DRHIAAWLSDQLGTEEIYLQATNERV........
A0A543C0Q5_9ACTN/226-314 rdvrtradvsgnaaspatal--------------..---------..----------------------.....-..----------.......----------------RNSAVTTARLQAMRQAVHATWENAESA..LADLG..........................................AGaddlGPFGA.DRDLARWFDRQLVHDIHFTEIQYEK-a.......
A0A4R1DVC6_9ACTN/221-356 ....................APFTRYLEGAARLR..HQASVHRAH..QHSFHAVCQHLSAASQRLAELC.....G..EVLANEAGPD.......DLLTAEAAISALYVGDQGLNQALRDLREMRHSVRITVDTMADL..LPPHP..........................................-V....NDTSG.DPELGRGLIALLDDDISHGESVKQEA........
A0A7W7MCH4_9ACTN/219-339 ....................PPLGRYLMHATKLR..YQARVLDAG..--QLRQLRSRLTGRVAEIRDRL.....R..--AGGPGEP-.......------VDLAAFAADEAELAAALGGLRRMRQSVRIARANMDRS..LP---..........................................--....VPLPA.DAEVAEWLTGRIDDDVEYLDATREEA........
A0A6F8XR89_9ACTN/285-322 ....................APLPRYLLDAAKVR..YQLRVREAA..EPSLRAA---------------.....-..----------.......-------------------------------------------..-----..........................................--....-----.--------------------------ltgqgtaa
A0A2I2KP68_9ACTN/247-374 ....................PTLVTYLAATAKIR..YQLRSWG-D..GVATHQLLERAERAARHVRAHL.....P..----------.......--LPDPTAVDEVRTVAVDLAALTASLATRRQSIRLAARNARSA..LRADGt........................................tPGe..hDVFGE.DLALASHVDDQLDADLIFLDAATRQ-v.......
A0A810NBD0_9ACTN/181-322 ....................APLTRYLMSMATIR..HQLRMWAHA..-DELRAARDEADTLLDRLLPTL.....D.dDPVAATTAEE.......TVLTWTRHLARLRSTEARLVTAATDLRRVRRTVQIAAANGDRA..IRPEVsp......................................dpAG...pGPFRD.DHALTEWFTHRLDDDGEYLDAARER-i.......
A0A0M8UWR4_9ACTN/220-356 ....................PPLTRYLLHSTKLR..CQEHVLVSA..MPRLRAAIEETEQACDTLVDLL.....R..---SGDPPLG.......QLLEAGRALATVQAEQGGLIAAAADAADMVETVRAARRNMDAA..LADVDd.......................................ctSG....GPVDM.DRAAGSWLEEQLGIELAYLESSRRRA........
K0K3J1_SACES/205-337 ....................PVLARYLLHAVKLR..HHVGVWQRD..EDWLTRLRTQVDTHVDELRTDL.....D.gTARAGVGGVE.......PGRDRAALADELRGDEAGLVVAADRVERMRKSVEIARVNMAAF..RP---..........................................--....RPLPA.DEGLAEWFLAQLGDTLDQVERSRGLA........
A0A6M1L7X5_9ACTN/196-340 ...................r-PLPAYLWEMANVR..HQARRLA-E..-RRMVYQPEALLERAGRFER-A.....E..-----VKHPR.......GAAVREAMLSTLRREVALVAAHEAVLRTMHRTVEAATANARVW..LEAGWvkpvspdv..........................ggdvvaphVS....DPVGQ.DLRYAKWLLVEILDEADTVRDAV---sya.....
A0A516RIQ3_STRST/209-353 ....................APLTRYALHAAKLR..YERAVLDRS..--RHGELRDRAGEAVRRASEVT.....A.rLLGGDRPALR.......EVLDARVVLVALRTDAQGLIVAAARLRMLRRTVEIARDNLVAA.vPGECDpapd..................................aalpEA....SPIAG.DLLLGERLRQDVDDELEYLQATIEA-s.......
F8AYB9_9ACTN/247-391 ....................PAFPRYLLHAARIR..YQIRVWSVE..QPELRRIRRETDEAISDLLHRL.....G.tGDGDAGGDVDei..sdaELFDGLQRLTRLELNDAGLALGSTRLREIRRTVEIARANMAKR..LPWTVt........................................pAG....GLFAD.DRELASWFDEQLDDDSSYAEATRERA........
A0A1H1Y8E9_9ACTN/208-313 ....................PPLGHHLRHAAVLR..HQVRVWQRA..-DGLRRVQDRLDDGGDPAEVRR.....D..----------.......------------------IAYWRSALRDMRRTVKNLETAIHEV..GGAEA..........................................--....GPLAD.DLAVAVWFRGALKDDLAALAVADERA........
A0A1H9JCD7_9ACTN/233-371 ....................PPLGKYLLHAARLR..YQLRVWSAA..G-SAGRLRDAADTAVTELLEQT.....-..AAPHGPGREA.......DLLRATRALVGLQARERGLVDRSTRSREMARTVEIAAANLAAL..GDSSPdg......................................ptPG....GPFAD.DRALAEWFGRRLDDESTYLEATLRRC........
A0A4R1HJ22_PSEEN/222-350 ....................TPLGRYLLQAATLR..HEYRLRGRR..--DGGTSLDEADRRCERVLALV.....R..-----GPITA.......DVDPALTALTELTSTGPELVTRATRLREGARNVTIARRNMVLH..LGPAV..........................................-A....GPFDD.DRRLAEWLERQLDNDLTYVDTALER-l.......
A0A5M3WCM8_9ACTN/223-347 ....................PPLARYLLQAAKMR..FHLRVWQRD..R-RTRELRTAIQAMEAELRR--.....A..GHDRRAIDLS.......PLDDFDA------------LLMAADLRELRRSVEIAMANLELV..ANRPEl.......................................ltPG....GPFAD.DRDLARWFVTQLGDDLDVVKASALRA........
W7ST62_9PSEU/209-326 ....................PPFARYLMHVAKIR..DQLRVRRHA..-PDTAELCRRIEDVLARCGSQP.....-..------VPP-.......-------------AVHIALARTITSLEVMAKTVRVSWENAVAA..AEVAIp.......................................aaGG....DPVSR.DRLLATWFDQQLRDDAEYLHH-----ydrgv...
A0A2T0RCI2_9ACTN/332-414 ................daal--------------..---------..----------------------.....-..----------.......-------RRATTTGAEGELVILTSLLDDLRLTVGIARSNMARV..LRTIGvd.....................................adaPA....GVFAD.DLGTADWFDETLADQLHYLGNARERA........
A0A4R2JHB5_9PSEU/219-337 ....................APLGRHLMHAAKVR..DSVRRFA-D..GHVTRKARRRLDEGVQRALFSV.....S..----------.......--------EGGLREDVDIVEMLLSRLTRLQSAAGITAGNLRQA..LGGRV..........................................TG...tGPLTD.DVALADWFTQRLADEQHSLAEALADA........
C7PYD3_CATAD/241-366 ....................PPLARYLLHAAKLR..YEMRVWRRD..G-QARELNEALDTLSSELIR-T.....G..A---------.......-TDSAKAELLRLRS--GQALMLLGDLKLLRQTAEIADDNMRRA..LSEAEq.......................................lrAV....NPFLR.DAADAQEFLELLDDQIAYLDTRTAR-s.......
A0A5M3XYX8_9ACTN/126-253 ....................PPFARYLLHAAKIR..YQVRVHDQG..-KRIRDLRGHTEGGIGKVDPDS.....-..----------.......-TATLEERLSLLHTNEADLLDVMTRLRIMQRTVKIAADNMAAV..LGQYSad......................................npDR....SVFGD.ESALANWFGKQLEDDLAYIEAAQH--hv......
A0A8J4DSW8_9ACTN/210-238 ....................PPLARFLLHAARLR..YELRVWEAA..EA--------------------.....-..----------.......-------------------------------------------..-----..........................................--....-----.--------------------------paed....
A0A1I2JCC6_9ACTN/261-401 ...................r-PLTRYLLHTAKLR..YEARQYAAA..-DPVVAHVDVTDRQTRELLQEL.....E.pAAAGEPISLG.......RVLRAANLLDRTQLGPQGMTWTITGLRQLSRTVAIAAANMRIH..APVVHr.......................................qgPG....VPWPAaDLAAAEALVAQADSDQVYLETTRERA........
A0A4R4XPL7_9ACTN/187-306 ...................s-PLARFLMHAAKVR..FQLRVYDEG..-RVFHEARERVDEQAARVVAAL.....E..--------DD.......RLLAAHRELMHRQAAPDGLIWTMTRLREMLRTVEIARHNMR--..-----..........................................-G....TPFED.DLALADWFRLRIQDDLGYADATRERA........
A0A1V9KGZ6_9ACTN/215-354 ...................r-PLARYLLQLSKIR..YQGRLYALS..-EPSRAQIAESDERTTALLREL.....D..SAARRPVPLE.......RLLRTSHLLDETQFGPQGLLWTITRQRQLTRSLSTAVANMALH..TPDPRrh......................................gaGV....SWTVT.DLADAEWLIKQVDEDRLHLEAARERA........
A0A7K1KTA6_9ACTN/203-331 ....................PFLGRYLMHMAKSR..YQMRVHATF..-PDVRDVCDRLRDGASDALSLA.....R..-------SLG.......QGDALADRLAELGLDQARASGRVAEAKTMRRTVEIALDNAAAV..LGPGT.........................................aES....GFVAD.DLRLARWFRQRLDDEIAYLDAASE--a.......
A0A6G2B5T9_9ACTN/233-370 ....................PPLGRYLLHAARLR..YQLRVWSAA..G-SAGRLRDAADTAVTELLEQT.....-..TAPHGPGREA.......DLLWATRALVGLQARERGLVDRSTRSREMARTVEIAAANLAAL..SGPLPg.......................................dsPS....GPFVD.DRALAEWFGRRLDDEATYLEAALRRC........
A0A6F8XR89_9ACTN/313-392 ...............aaltg--------------..---------..----------------------.....-..----------.......------------QGTAAEMAVLLTRLADMRLTVEIARSNMDAV..LRTIDpwg....................................gapLG....GLFAD.DRACAAWVESRLADDVRYMTNAHRRA........
A0A1S1R1R4_9ACTN/211-351 ....................TPFARYLMHAAKLR..YHLRVWA-G..GDPLRTVRDRTDQLTESVAGLL.....D..EQLAAGGALP.......RQDEGRTRTGDLRAQALHLALSMTRVREIRHSVEIAGYNLAQY..APPADah.....................................ggnGG....GLFAD.DRDLASWFPQQLDDDLRYADASAERA........
A0A8J3HP52_9ACTN/222-358 ....................PPLARYLLHAAKLR..YLLRVWERD..R-HAGRGRVDLGALADRLRSLA.....-..-KEPGPADAE.......LLKSVLGQLDRLHQDGLESAMFGASLKELRLTAEIALSNMAKV..VAAESv.......................................pdHC....DLVAD.DRAVGGWLLDQIGTDLRYLDL-----dsgra...
A0A4U3MJM4_9ACTN/207-275 ..............tfdagr--------------..---------..----------------------.....-..----------.......---------------------RIGDIRRMRHTVDIAADNMLRS..FDLTPl.......................................llQG....GPFAD.DADLVKSLIERLDDDARYLHDSID--pa......
C7PYD7_CATAD/230-405 ....................PPFGRYLMHMAKIR..HELRIHA-G..GDAVRRLRTEADSRVERLLQLL.....E..--GEIPAGPA.......ELVAASTRLAVLRVQSAGLIAALTRLREMRRTVQIAQWNMAAA..LGEDGgiegqasavsgpghirarasdnevggpvsgrpgttgsrpgtpPA....TPLTD.DRALADWFATRLDDDALYVAAACDR-t.......
A0A8J4DSW8_9ACTN/234-291 .................apa--------------..---------..----------------------.....-..----------.......----------------------EDRLVLLHRVVEIAGDNLRLA..LPDDLl........................................gAD....GPLVE.DVRLAAWVTRRLEDDR----------frra....
A0A4U3MJM4_9ACTN/176-213 ....................PPLARYLLHAAKMR..YELGVWLRD..G-GGRPIPGT------------.....-..----------.......-------------------------------------------..-----..........................................--....-----.--------------------------fdagrr..
A0A4R6RRX8_LABRH/215-331 ....................PPFARYLMHVAKIR..DQLRVRRQA..-PGTTELCQRVEDTVARFGD-A.....-..----------.......---------GVPTAAHSALSRMITSLTVMAKTVRVSWDNAAAA..IGIESs.......................................ieTN....SVITR.DHTLATWLHQQLTDDAEYL-------ihfdee..
A0A1Y5YAA2_KIBAR/215-331 ....................PELARYLLHMAKVR..YQLRVHARL..-PEAGMLCRTIDDAVAQRDQ--.....-..----------.......---------AALSTSRFRIARHVTNLKTMRHTVEIALSNAVAA..LKRVAd.......................................lpQD....GPIGD.DLALGTYFRQRLDDDIRYLETSAEGA........
A0A7W9DQK5_9ACTN/224-349 ....................PPLARYLLHAAKIR..YELRVWLRD..G-QARQLRDTIERLATELRR-L.....G..A---------.......---GAAVQAELLRLRRLDALMLHADLRALRHTVDIAADNLGRA..FDLSAl.......................................vaPD....GPFAD.DAGLARSLLERLDDELAYLAMATDRA........
A0A7W7WRP1_9ACTN/208-342 ...................g-PFVQYLLDAAKLR..YQHADHRAS..ATAIRRLRLEMDNTVDDLLDLH.....-..--KSATTAPG.......QLVAADASLTDLQVRTHGVIFTLAQLRKTARGIEAAEANLRATvsLDPAA..........................................-P....GPLAA.DLALAQSVCERLADDIAYLEISQERA........
A0A438M8U0_9ACTN/187-306 ....................PPLVRHLMHAAKLR..YQLRVYRQG..-EDFRAARHRVDEQVETLLKTL.....G..-----GD---.......GLPAARRELAARQTAEAGLIWTLTRLREIRTTAAIARHNMREP..-----..........................................--....-SLRD.DLDLADWFLMRLDDDLAYAEATRERA........
#=GC seq_cons ....................sPLsRYLlcAAKlR..aphRVapts....thptlppphcptssclht.h.............................htt.hstlphttttlhhthscL+php+oVcIAtsNhtth..hs..............................................s....ushs-.DhsLApWhtppLsD-htYlcsutcps........
//
