#=GF ID CCC_C_2nd_pro
#=GF AC PF21554.1
#=GF DE Prokaryotic cation-chloride cotransporter, C-terminal domain, 2nd
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE ECOD:EF20962
#=GF GA 27.00 27.00;
#=GF TC 41.10 39.90;
#=GF NC 26.30 25.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RC Paper describing PDB structure 3g40
#=GF RN [1]
#=GF RM 19368887
#=GF RT X-ray structure of the C-terminal domain of a prokaryotic
#=GF RT cation-chloride cotransporter.
#=GF RA Warmuth S, Zimmermann I, Dutzler R;
#=GF RL Structure. 2009;17:538-546.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found at the C-terminal end of a group of
#=GF CC prokaryotic cation-chloride cotransporters (CCCs), including
#=GF CC Na-K-Cl cotransporter from Methanosarcina acetivorans
#=GF CC (Swiss:Q8THK8). These proteins consist of an N-terminal
#=GF CC transmembrane transport region (Pfam:PF00324 and Pfam:PF13520)
#=GF CC followed by a cytoplasmic regulatory domain. The C-terminal
#=GF CC domain adopts a compact trapezoid-shaped elongated structure
#=GF CC with a mixed alpha-beta fold and can be divided in two
#=GF CC structurally related subdomains. This entry represents second
#=GF CC subdomain, which shows a central five-stranded parallel
#=GF CC beta-sheet and three alpha-helices that pack on either face of
#=GF CC the sheet [1].
#=GF SQ 73
#=GS A0A2S0HZJ5_9FLAO/596-728 AC A0A2S0HZJ5.1
#=GS F7XLM3_METZD/616-748 AC F7XLM3.1
#=GS A0A4R6TPD3_9FLAO/593-724 AC A0A4R6TPD3.1
#=GS A0A1M6ABL9_9FLAO/593-724 AC A0A1M6ABL9.1
#=GS A0A4E0Q9E1_9EURY/614-746 AC A0A4E0Q9E1.1
#=GS A0A069RNA6_PEPLI/578-699 AC A0A069RNA6.1
#=GS A0A6L9EET1_9FLAO/595-727 AC A0A6L9EET1.1
#=GS K9SFQ5_9CYAN/614-750 AC K9SFQ5.1
#=GS A0A8J7QCZ7_9BACT/611-744 AC A0A8J7QCZ7.1
#=GS W9DNA6_METTI/614-746 AC W9DNA6.1
#=GS A0A6P1ZCL3_9DELT/641-776 AC A0A6P1ZCL3.1
#=GS A0A2P6C508_9BACT/604-736 AC A0A2P6C508.1
#=GS A0A265UU25_9FLAO/568-700 AC A0A265UU25.1
#=GS A0A498H374_9EURY/587-719 AC A0A498H374.1
#=GS A0A2S7KP52_9FLAO/597-729 AC A0A2S7KP52.1
#=GS A0A0S1SDA8_9FLAO/593-724 AC A0A0S1SDA8.1
#=GS A0A316DRU4_9FLAO/597-729 AC A0A316DRU4.1
#=GS A0A0D5YQ10_9FLAO/597-729 AC A0A0D5YQ10.1
#=GS A0A7H5EZR1_9BACT/589-722 AC A0A7H5EZR1.1
#=GS A0A8A4TDF6_9BACT/618-751 AC A0A8A4TDF6.1
#=GS A0A553GA13_9BACT/596-728 AC A0A553GA13.1
#=GS A0A2A8D446_9BACT/593-725 AC A0A2A8D446.1
#=GS W8TK44_PEPAC/588-709 AC W8TK44.1
#=GS A0A8J2XFZ1_9FLAO/599-729 AC A0A8J2XFZ1.1
#=GS A0A0E3NTY8_9EURY/611-742 AC A0A0E3NTY8.1
#=GS A0A8J7JDP1_9FLAO/46-177 AC A0A8J7JDP1.1
#=GS A0A1Y0MQ10_9FLAO/597-729 AC A0A1Y0MQ10.1
#=GS A0A1Y6CNI8_9PROT/617-750 AC A0A1Y6CNI8.1
#=GS A0A521E196_9BACT/609-740 AC A0A521E196.1
#=GS A0A1B6BA25_9FIRM/571-704 AC A0A1B6BA25.1
#=GS A0A2T5C3Q1_9BACT/599-731 AC A0A2T5C3Q1.1
#=GS A0A4Y6PQA0_9DELT/605-737 AC A0A4Y6PQA0.1
#=GS A0A2H3NQT7_9BACT/634-766 AC A0A2H3NQT7.1
#=GS A0A2N0VIX9_9BACT/607-738 AC A0A2N0VIX9.1
#=GS A0A4Y6PTT6_9DELT/639-772 AC A0A4Y6PTT6.1
#=GS A0A1G7WEJ0_9FLAO/600-730 AC A0A1G7WEJ0.1
#=GS A0A2A2GC67_9BACT/609-740 AC A0A2A2GC67.1
#=GS A0A316TLM3_9BACT/606-737 AC A0A316TLM3.1
#=GS A6DJU2_9BACT/616-749 AC A6DJU2.1
#=GS A0A850GPQ9_9DELT/269-404 AC A0A850GPQ9.1
#=GS A0A2A8D164_9BACT/630-762 AC A0A2A8D164.1
#=GS A0A5C7GN60_9FLAO/598-731 AC A0A5C7GN60.1
#=GS H1XRS4_9BACT/596-720 AC H1XRS4.1
#=GS A0A2H3P2B9_9BACT/636-768 AC A0A2H3P2B9.1
#=GS Q2S0B9_SALRD/682-814 AC Q2S0B9.1
#=GS A0A328C629_9DELT/701-834 AC A0A328C629.1
#=GS A0A425XYK9_9BACT/595-726 AC A0A425XYK9.1
#=GS Q4C7G4_CROWT/136-271 AC Q4C7G4.1
#=GS A0A4S3M3N7_9FLAO/594-727 AC A0A4S3M3N7.1
#=GS A0A5D3YIF1_9BACT/609-740 AC A0A5D3YIF1.1
#=GS A0A2Z4FHP6_9DELT/655-788 AC A0A2Z4FHP6.1
#=GS A0A3L9YD23_9FLAO/599-729 AC A0A3L9YD23.1
#=GS A0A6M1TEI0_9BACT/609-740 AC A0A6M1TEI0.1
#=GS Q8THK8_METAC/626-757 AC Q8THK8.1
#=GS A0A1M6J9D2_9FLAO/593-724 AC A0A1M6J9D2.1
#=GS A0A2H3NX17_9BACT/632-765 AC A0A2H3NX17.1
#=GS A0A7H5EWL5_9BACT/589-722 AC A0A7H5EWL5.1
#=GS A0A7C8HI18_9FIRM/583-704 AC A0A7C8HI18.1
#=GS A0A0G3W988_9CLOT/580-706 AC A0A0G3W988.1
#=GS A0A6S4QIF0_9SPIR/637-772 AC A0A6S4QIF0.1
#=GS Q12YP5_METBU/42-174 AC Q12YP5.1
#=GS A4ARZ3_MARSH/597-729 AC A4ARZ3.1
#=GS A0A850G596_9DELT/629-764 AC A0A850G596.1
#=GS A0A6M1ST56_9BACT/607-738 AC A0A6M1ST56.1
#=GS L8LYA9_9CYAN/631-766 AC L8LYA9.1
#=GS A0A2P6C3F0_9BACT/615-747 AC A0A2P6C3F0.1
#=GS A0A1M5R0M9_9CLOT/583-704 AC A0A1M5R0M9.1
#=GS B1WRZ6_CROS5/602-737 AC B1WRZ6.1
#=GS A0A371JUN3_9FLAO/597-729 AC A0A371JUN3.1
#=GS H6LIP2_ACEWD/584-706 AC H6LIP2.1
#=GS A0A3B0C9A9_9FLAO/597-729 AC A0A3B0C9A9.1
#=GS A0A411E8Z7_9FLAO/597-729 AC A0A411E8Z7.1
#=GS A0A371QIM6_9BACT/607-738 AC A0A371QIM6.1
A0A2S0HZJ5_9FLAO/596-728 ..............GQRNTINVWVSNRKNNWSL..GWD....IGNLDLSTLIAYKLMKNW.K.ARIRLITVIDDVEEVENATKFLDSLINLARL.P.ETL..ME..VCV.GD.FKD..V...vTAAPHADLNIFGM...QEDLRFEFVQEMTSKTNSSCLFVKDSGH..ESIL.
F7XLM3_METZD/616-748 ..............GRENSINLWINDRSPDWDI..SMD....LGNQDLAILIAYKLKINW.N.ARLKMITCVNEQYNVYKAERYLANLAELARI.P.NVT..YK..VMV.GDmESN..I....SKAPQASINVFST...DSDIDFDFIHKTVDQTGSSCLFAMDSGE..ENAL.
A0A4R6TPD3_9FLAO/593-724 ............ie---KNINLWMTNIPRNWKE..SFN....IRENNLSTLISLLLRKNW.K.GTIDV-KILNNDPELIFTEQDLNDLRTMVRF.P.KST..TF..ELK.QG.HLLdqV....KSEKSTDVNIISI...EGKMTIEEMVLIVNESRISAIFCGDSEF..ENV-m
A0A1M6ABL9_9FLAO/593-724 ............ie---KNINLWLTNIPTNWRE..TFN....IGNNDLSTLLSLLICKNW.K.GEIDVI-IVDDTQNTQFSETDIEDIKTMIRF.P.NKT..TI..SVKnGN.LLD.nV....KKYRNADVNIFSV...DADMTTADMISIVYESRISGIFCVDSNL..ENVL.
A0A4E0Q9E1_9EURY/614-746 ..............GRMNSINLWIDDHSPDWDI..SMD....LGNQDLAILISYKLKKNW.E.ASLRMITNVQEQHNVYKAKEYLENLAEIARI.P.NVK..DK..VLL.GDiRSN..I....SKAPQASINIFSM...GPDPDFDFIRSAVERTGSSCLFALDSGE..ENAL.
A0A069RNA6_PEPLI/578-699 ............gl--ERRINLWLRDQSP----..---....--NNDLASLCALQFSRNF.G.AELNLCRVVDDENIKKQTVKDMMDFIEEARL.P.ANT.kVR..IFS.GD.FKD..C....LHENNADLNIIGM...P--MEYEAMIEMIDNSPSSILFVASGGL..ENAL.
A0A6L9EET1_9FLAO/595-727 ..............GQRNVINVWVSDRTDNWNL..GWD....IGNLDLSTLIAYKLKKNW.E.AQIRLIIVIRDEKEKENAHNFLQSLTSLARL.P.STL..TE..VHI.GS.FRE..V...vQKAPKADLNIFGM...DGNLKFEFVNEMTSKTGSSCLFVKDSGH..ESIL.
K9SFQ5_9CYAN/614-750 ..............GQGATINLWIRPQ-IDDEI..PMQerlrLGSINLSVLLAFKLARAW.D.AELNLISTVTEPSQMEAAKAYVDALKDLCRI.P.NRS..LT..YMM.MG.HLD..Ac..mAIAPRADISFIGL...AAIPDFDFVTRMQGLANSSCLFIGDSGG..ESAL.
A0A8J7QCZ7_9BACT/611-744 ..............GRERTVNLWVRDQSPDWQL..SLK....LSNLDYAVLMSIQLKLNW.Q.ANSRILTVVREEEHVELAQRFLGNLLAYARM.P.NDV..EI..IAE.HG.RFDdfL....RKAPRADLNIMGL...SGQVDKAGMERLVRECHGSCLFVLDSGY..ASAL.
W9DNA6_METTI/614-746 ..............GRQNSINLWINDRSPDWDI..SMD....LGNQDLAILIAYKLKKNW.K.ASLKMISCVKEQYNNYKAEQYLENLSELARI.P.NVS..TK..ILL.GDiESS..T....GNAPQASINVFSM...EPDVDFDFVRKTVEDTGSSCLFALDSGE..ENAL.
A0A6P1ZCL3_9DELT/641-776 .........sregg-----VHLVIDTPEDGWRI..GTD....LGHADLATLLAYKLKTNW.K.TRLTITARIQNADERKDALDYLRAAVELARI.P.NAM..LR..LAE.SEeELD..YsvaaGEEPP-AITIFSM...VAPAEFDTLRTRGKRVRTPCLFAMDSDR..ENAL.
A0A2P6C508_9BACT/604-736 ..............GQRQTINVWIKDRTPDWRL..SME....IGNLDLALLTAYKLSQNW.N.ARMRVVTAVPDPNEQEKAQDFLEKLMDLGRF.P.NAE..A-..VVG.PK.PFNeyV....PEAPQADLNIFGL...QPDPDFDTIRDLVTQTDSTCMFVRDSGR..ESAL.
A0A265UU25_9FLAO/568-700 ..............GQRKTINVWVSDRTGNWEL..SWD....IGNLDLSILIAYKLKMNW.G.AKIRLITVVKSAEEEINATDFLNQLINLARL.P.DTL..IE..VHL.GD.FKT.vV....ADAPPADLNIFGM...DDTLAYTFLKDMTEKTGSSCLFVKDSGH..ESIL.
A0A498H374_9EURY/587-719 ..............GRRRRINLWVPAACTAWTP..GEK....LPNCDLAILVAYKLAINW.G.AVVTFITTVEDPAGVPAVRESLSALLEQVRI.P.HAE..LL..VVN.RRyEEY..L....GSEPQADLTVFSL...SSKPDFAAVRTIVEKTRSTCLFCRDSTL..ESAL.
A0A2S7KP52_9FLAO/597-729 ..............GKRKMINVWVSDRQGSWTL..GWD....IGNLDLSTLIAYKLKKNW.E.ASIRLITVIGNEKEMEEARAFLEDLVNLARL.P.NTL..IE..VHH.GR.FRD.yV....PDAPQADLNIFGM...DQDLPFQFVEEITLLTQSSCLFVKDSGH..ESIL.
A0A0S1SDA8_9FLAO/593-724 .............i--EKSINLWMTNIPVDWKE..TFS....VRNNNLSTLIALLIRRNW.K.GSIEV-NILNNNPKMNITPTDIEDLRTMVRF.P.KHT.nIS..IKQ.GD.LLE.nV....KMERNTDVNIFSI...ENGMTIETMVKMVNESRISAIFCADSEF..ENVL.
A0A316DRU4_9FLAO/597-729 ..............GQRNMINVWVRDRKDNWDL..GWD....IGNLDLSILVAYKLKKNW.D.ASIRLIIVIDDEGEKENAQQFLLTLINLARL.P.ETL..TE..VYV.GN.FKE..I...vEKSPAADLNIFGM...EGNLQFEFVKEISAKTGSSCLFVKDSGH..ESIL.
A0A0D5YQ10_9FLAO/597-729 ..............GQRNVINVWVSDRRGNWEL..GWD....IGSLDLSILIAYKLKKNW.D.ARIRIITVISDADEEENAKNFLKSLINLARL.P.DTL..IE..VHV.GN.FKE..I...vGNAPKADLNIFGM...DEHFKIAFVEEMTEKTASSCLFVKDSGH..ESIL.
A0A7H5EZR1_9BACT/589-722 ..............GQQQAINVWMRPQGPQWKV..AHA....HQTQDLALLLAYKLKRNWnD.AHIRMMTVIEDEEDRPKAQAFLHEVIELARL.P.IDE..TL..VAV.GDfKTH..L....EEAPLADINLLGI...TPGRDIDAYREIAVMVDTTCLFVLDSGH..ENI-y
A0A8A4TDF6_9BACT/618-751 ..............GRERTVNLWVRDQSPDWHL..GLK....LSNLDYAVLMSYQLKVNW.Q.AKARMLTVVKDPGHVEMADRFIRNLLEYARM.P.GDI.eVL..AKA.GN.FSD..F...lIEAPRADLNIMGL...SDKVDKQAMENLVRATQGSCLFVLDSSY..ASAL.
A0A553GA13_9BACT/596-728 .............r-KRQVINVWIRNRAPEWKI..SWD....IGNLDLSILVAYKLKRNW.G.AKIRLVTVVDNEEQKEQALNFMHELIDHARL.P.KTE..MG..VYV.DD.FSA.lI....KRAPEADLNIFGL...DTHPNLQFMDKMVDETQTTCLFIRDSGL..ENI-f
A0A2A8D446_9BACT/593-725 ..............GQRETVNVWINDRSPDWKV..SMD....IGNLDLPVLMAYKLKRNW.N.AEMRLLTVVRSEEQADDARAFLHTLTDLARM.P.EAT..AE..VHV.GDfESY..L....EEAPRGDVNIFGL...MDPPNFARMREIVTRTRTSGLFVRDSGT..ESAL.
W8TK44_PEPAC/588-709 .............g-SERIINIWLRDRSP----..---....--NNDLAVLSAIKMVGNL.G.AELRLCRVVGHKSHIEKAEEELAKFIEEARL.PgNTQ..IK..VFT.GD.FYR..H....IEEERADLSIVGM...PT--KYEHMIRMIDLAPGSLLFVASGGL..ESLL.
A0A8J2XFZ1_9FLAO/599-729 ...........ler----DITLWLKEFPSGWKT..NFD....IGNNDISILTALMLQKNW.K.GNINVKVALDS-LGMQ-NEEDISLLNDLVRF.P.VNS..IIesYDI.QS.EAS..L....LKSNNSDINIIPI...LKENNIKEMIEIVNFTRTSAIFCLDSLN..ENAL.
A0A0E3NTY8_9EURY/611-742 ..............GRRNSINLWVEDRGPAWEI..SMD....LGNLDLALLTAYKLKRNW.K.ASLSFTALIDSPSRIRAARDFLYSLADLARI.P.NVA..VR..VLH.EG.LEK..S....SGVPSASLHIFCL...SPDPDLDLARALTEKTGSSCLFALDSGE..ENAL.
A0A8J7JDP1_9FLAO/46-177 .............i--EKSINLWITNIPIDWKE..SFN....IKDNDLSTLISLLICKNW.K.GTIE-VQILNNNNQIKFSETDIEDLLTMVRF.P.KNT.sVT..VKH.GD.LLD.nV....TRERNTDVNIFSI...EEGMSVEDMVKIVNQSRISAIFCADSDF..ENVL.
A0A1Y0MQ10_9FLAO/597-729 ..............GQRDTINVWLSSRKDNWNL..GWD....IGNLDLSTLIAYKLMKNW.Q.AKIRLVMVIADESQRENAENFMQQLISLARL.P.ETL..TE..IFV.GN.FRA..I...lPAAPRADLNIFGM...DADLRFEFVEEMTQATNSSCLFVKDSGH..ESIL.
A0A1Y6CNI8_9PROT/617-750 ..............GREREINIWIRDQSPDWTL..GLR....LANLDLAILLGYQLNRNW.K.GKINLVTVINKKENIAPAHEFLHSLAKDARL.P.TNTdiFL..YHG.EF.ENQ..I....EHAPRADVNIFGL...SRNIGPDRLRDLAIKTNSSCLFVLDSGN..ESAL.
A0A521E196_9BACT/609-740 ..............GRSASVNVWIHEQSPEWDL..SME....LGNVDLAMLTAYKLKVNW.N.ARMRIITVVEEP-EVEKAYQYLNNLLDVARL.P.DVI..PH..VEI.GNfETV..M....RNAPQADVDLLGL...PEEPDLDKLRSYVEETQSACVFVADSGN..ENIL.
A0A1B6BA25_9FIRM/571-704 ycclwihpkmgfgi--ENKINLWLRSKS-----..---....-PNNDLAVLCALQLSRNF.G.AELNLCRVVRNEAEQEETVKKMLTFVEDARL.PvNTK..VR..VLL.GS.FHE..N....IVTTHADLNIIGM...P--VSYESMIEIIDIVPSSALFVSSIGH..EDV-m
A0A2T5C3Q1_9BACT/599-731 ..............GQRQLINVWIRNRAPHWKI..TWD....IGNLDLSILIAYKLKMNW.N.ARIRLIMVVENEEQEKQAFQFMSELIDLARL.P.KTE..IT..VHI.GS.FID.fA....KDAPEADLNIFGL...TPEPSFDFMEDMVEDTSTTCLFIRDSGA..ENIL.
A0A4Y6PQA0_9DELT/605-737 ..............GSKKVINLWVHDRNPDMEL..VLR....ESHINLAILVAYMVTQNW.K.GRLNLVSCVEEDRTHEEVRQELQRVIDLARL.P.DPE..IH..LLD.GP.FID.nL....DKGPRADVDIMGL...SRPPNFELMREAISKTRSTCVFVADSGK..ESAL.
A0A2H3NQT7_9BACT/634-766 ..............GQRETINVWINDRSPHWRV..SMD....VGNLDLLILMAYKLKRNW.D.AEMRLLTVVDTEEDAQAAHTFLHMITDLARM.P.DAE..IV..VHV.GD.FQA.yL....SNAPRGDVNVFGL...MDPPRFERMRALVSQSRTSSLFVRDSGN..ESAL.
A0A2N0VIX9_9BACT/607-738 ..............GRSASVNVWIHEQSPKWDL..SMD....LGNIDLSMLSAYKLSHNW.N.ATMRVITVVE-ESEVENAYEYLENLLDISRL.K.NVI..PH..VEI.GS.FEE.aM....QSAPQADVDFFGL...PDDPDLEKLRYFVKVTQSACVFVADSGN..ENIL.
A0A4Y6PTT6_9DELT/639-772 ..............GHERTINVWIRDQSPDWPL..GLR....LSNLDLSLLLAYQICRTW.N.GEIRFMTICDDPDNVEEAENYLEQLVEDARL.N.RYG..KT.wVRS.GN.FME.eL....RRAPRADLNIFGL...ARDVDMEFLRKLVRETQHSCLFVRDSGH..ESAL.
A0A1G7WEJ0_9FLAO/600-730 ............ie---KSIHLWLKNIPSDWKE..SFD....IGNNNLSILTSILMSQNW.K.GTLNVH-VVCEEENCFTSD-DIKRLNYMVRF.P.KNT.nLD..VRQ.GDlKEH..V....ARGRSADINIFTT...FEDMKIEDMVELVNSSRISGLFCLDSSQ..INAL.
A0A2A2GC67_9BACT/609-740 ..............GRSSAINVWIREQSPDWDL..SME....LGNVDLSLLTAYKLKMNW.K.AQMRVITVVED-SQVEEAYRYLDNLLDAARL.P.DVL..KH..VEV.GT.FNE..A...lQNAPQADLDLMGL...PNDPDLEQLRSYVETTQSACVFVADSGN..ENIL.
A0A316TLM3_9BACT/606-737 ..............GRSDSINVWLREQSPDWDL..SMD....LGNIDLALLSGYKLKKNW.G.ARMRVIVVVE-EGQEEAAHAYLEDLLDVARL.K.GVI..PH..VEI.GT.FED..A...lGNAPHADVDFFGL...PDEPDMETLRSYVEQTRSACVFVADSGD..ENIL.
A6DJU2_9BACT/616-749 ..............GQQKSVNIWVRDQSPDWNL..GLY....MTNVDMLALTAYKIAGNW.K.GKICLCCAVSKEEYKRPTRKFFKNLTSLARL.GsNVE..IF..VTD.ES.FSN..A...lHSVDKADLNIFGH...SDELTKQAMEDLTKNLGTTCFFVRGSGI..ESI-m
A0A850GPQ9_9DELT/269-404 ..............GREQVVNVWLDLSAQGSSIaeVLT....EGNSHLALLLAYRLARAW.E.AELNIVGTISRAEDEASARAQVDEIRDLARI.P.ATG.rTH..ILV.GEiEAV..A....HLSPQSDFDIIGL...RAGDDLAFMNRMVEATRSSCMFTLDSGN..ENVL.
A0A2A8D164_9BACT/630-762 ..............GQQQTINVWIRDRSPEWNI..SMD....IGNLDLALLTGYKLSQNW.D.ARLRVLTVTNDPKEEARAQEFLDTLTDLGRI.P.DPE..IV..VRS.GD.FRD.hV....RDAPQSDLSIFGL...DPNIDFAFSRALVETTESTCLFVRDSGL..ESAL.
A0A5C7GN60_9FLAO/598-731 ..............GQRNTINVWVSNRKGNWEL.gGWD....IGNLDLSLLIAYKLKMNW.E.ASIRMIIVVDDPKEEDNAKNFLKRLKSLARL.P.KTL..TE..VHV.GI.FDE.fV....LKAPSADLNIFGM...QETLPFDFIKNMTTKTNSSCLFVKDSGH..ESIL.
H1XRS4_9BACT/596-720 ............gl--QQNINLWLRDQSPNWH-..---....-----LAILISLQLQLNW.G.GKLNLITATEDPAKKQQLLHFLEKLSDRARL.P.SMT..EY..YVL.EG.KFK.eA...lAQAPTADINIFGL...ADHLPFDFMRQAPELVNASCLFVRDSGL..ENAM.
A0A2H3P2B9_9BACT/636-768 ..............GQREVINVWIHDRSPDWRI..AMQ....TGNLDLALLAAYKLSQNW.D.AKLRLITIVDDPDELEKARDFLAKLIDLGRI.P.NAT..LI..AEH.GE.FKD.yV....QQAPHADLNIFGL...LPNPNFAFFRELVSTTESSCVFVRDSGR..ESAI.
Q2S0B9_SALRD/682-814 ..............GQRQTINVWIRDRSPDWRI..SME....IGNLDLALLTGYKLSQNW.D.AQMRLVTAVADPDQQGTAQDFLEKLIDLGRF.P.DST..A-..VVG.TD.PFD..Ay..iKAAPQADLNIFGL...QPEPDFDTIRRLVDQTDSTCMFVRDSGR..ESAL.
A0A328C629_9DELT/701-834 ..............GHERRINVWVRDQSPDWPL..GLR....LANLDLSLLLGYQAQRNW.Q.GILRLLTVCPDPAEVDNACRYLQLLVDDARL.P.RDT..RQ..WVE.SGsFMK.wL....HDAPRADLQIMGL...ADTIDREFMERMVAATGSSVLFVRDSGN..ESAL.
A0A425XYK9_9BACT/595-726 ............ie---KNINLWMTNIPVDWKE..KFN....IMNNDLSTLVSLLICRNW.K.GIIDV-HILNNNEKLNFSEVDLEDLHTMIRL.P.KNS..TM..TLK.QGtLIE.nV....NLERNTDVNILNI...EQGMGVDDMVKIVNQSRVSAIFCADSEF..ENVL.
Q4C7G4_CROWT/136-271 ..............GRMEVINLWIRPQLDDLPImeRLE....KGNTDLAILMSLRLAKAW.K.GELNIISVIDKEEDRQETENYINSLKDLCRI.P.RTAksLI..IVG.KF.PDC..I....KQTPQGDIDFIGL...QSIPDFQFVHQMIDMTGSSCLFMSDSGS..ESAL.
A0A4S3M3N7_9FLAO/594-727 ............gl--EKSINLWLADIPENWET..KRE....LGNNDLAILMGLLLEENW.D.ARLNIILELNPEQTTGEGQIFLKRLKESARL.P.KNV.gFH..LVR.KD.TPE..L...wNKVPPADLSIASF...DADSPLTDLLVVVQNHRSSFLFTADSGR..ENA-q
A0A5D3YIF1_9BACT/609-740 ..............GRSETINVWIHEQGPDWDL..SME....LGNMDLALLTAYKLKVNW.G.AQMRVITIVDEP-QVEEAYRYLENLLDVARI.P.DAT..PH..VEI.GTfQGI..M....EDAPQADLNLMGL...PEKPDLDDLRSYVEKTQSACVFVADSGK..ENIL.
A0A2Z4FHP6_9DELT/655-788 ..............GHERTINVWVRDQSPNWHL..GLR....LANLDLSLLMAYQICKTW.N.GKIRLLCACDKEENVAAAEAYLNQLIEDARLvP.YCT..TW..VQP.GD.FME.qI....KVAPSADLNVFGL...PNEINNEYLVKLVRKTEHSCLFVRDSGY..ESAL.
A0A3L9YD23_9FLAO/599-729 ............le---KNLSLWLSNFPKNWRN..DYD....LGNNDLAILTSLLLAKNW.K.GELNAKVALDEEGIITQ--SDISILNDLIRF.P.VGS..NI..ESF.TT.EAK..Ae..yFGKNSTDLNILSL...PSDSKIEELIKVVNQSRTSAIFCMDSTT..ENAL.
A0A6M1TEI0_9BACT/609-740 ..............GRSSAINVWIREQSPGWDL..SME....LGNVDLALLTAYKLKVNW.D.AQMRVITVVDEP-QVEAAYRYLDNLLDAARL.P.EVL..KH..VEI.GA.FNE..A...lQNAPQADLDLLGL...PNDPNLDELRSYVETTQSACVFVADSGN..ENIL.
Q8THK8_METAC/626-757 ..............GRQNLINLWIENRGLDWDI..SME....LGNMDLALLIAYKLKSNW.K.ASLSFMTFAPTAIQAQAAENFLQSLAELARI.P.NVK..MQ..VLR.EN.PIK..S....SKLPFASLHIFSL...DPNPDLDLARHLMEKAGSSCIFALDSGE..ENAL.
A0A1M6J9D2_9FLAO/593-724 .............i--EKTINLWMTNIPVDWKE..TFS....VGNNNLSTLISLLICRNW.K.GLIEVH-ILNNNPKLTLSPNDIEDLRTMVRF.P.KKT.tID..IKH.GD.LMD.nV....NMEKNSDINVFCI...QPGMPIETMVKIVNQSRISAIFCADSEY..ENVL.
A0A2H3NX17_9BACT/632-765 .............s-QERRVNVWVTDQSPEWSL..GMR....MPNLDLPLLLALQIRHDW.N.CTLRLVTICSDTDEMPNARHFHERLIEDARL.P.ADT.eSF..VMQ.GD.FFD.kV....EKAPEVDLNIFGI...ARTADPEAMRRLVEITGTSCLFVRDSGR..ESAL.
A0A7H5EWL5_9BACT/589-722 ..............GQQQTINVWIRPQGPKWKV..AEA....HQTQDLALLLAYKLKLNW.NnAHVRIITVIEDADAKKSAAKFLKEVIELARL.P.IDE..TL..VIV.GD.FTE.qL....NNTPPADINLFGV...TPGRTMQQYQEVATAVDTSCLFVLDSGH..ENI-f
A0A7C8HI18_9FIRM/583-704 .............g-QEKNIHLWLRSKS-----..---....-KNYNLAVLSAIQIMKNW.N.GNLTLCRVAEHASQVPNIEKELLKFIEDARL.PiNTK..ID..VKV.GN.FYD..L....IKEQSTDLNILGM...SNS--LGQIENIIDQVPASILFVGDSEL..ENVL.
A0A0G3W988_9CLOT/580-706 ..............GQSKKINLWLRDKSP----..---....--NNNLAVLSALQISKNW.S.AKVTLCRIVSSTANIRQVEEELKEFIKDARL.P.TNT.rIM..VKC.GN.FED..V....ITNESTDLNILGMptyNDEINFEYIVKIMNLVPSSILFVADSGL..ENAL.
A0A6S4QIF0_9SPIR/637-772 ..............GREKEVVIWVRDQTPDWQL..SFS....MSNLDYAILLGYQIKKNW.N.GHLRLVCAVADEARVDYATDYLEQLSEFARL.G.DRV.sVH..VLP.QQfEVA..I....KQFTSADLHIIGL...GDRLDKRSLLRLSHLAKSSCLFVKDSGAglESA-l
Q12YP5_METBU/42-174 ..............ERHKSINLWIDDKSPEWEI..SMD....LGNMDLAILVGYKLKRKW.K.ASMNLITAVDDEEQKKKAVEYTQTLAELARL.P.NVN..HF..ALI.GSiEGI..A....HEAPQAALNIFNL...SNEPDFELIRRMVELTGSSCLFTIDSGE..ENAL.
A4ARZ3_MARSH/597-729 ..............GKRNMINVWVSDRTDNWHL..GWD....IGNLDLSTLIAYKLKKNW.E.ATIRLIIVIKNEKEKENADKFLNSLVNLARL.P.KTL..TE..VHV.GN.FME..I...vGDAPTADLNIFGM...DENLKFEFVKTMTMKTESSCLFVKDSGH..ESIL.
A0A850G596_9DELT/629-764 ..............GREQVVNVWLDLSAQGSSIaeVLT....EGNSHLALLLAYRLARAW.E.AELNIVGTISRAEDEASARAQVDEIRDLARI.P.ATG.rTH..ILV.GEiEAV..A....HLSPQSDFDIIGL...RAGDDLAFMNRMVEATRSSCMFTLDSGN..ENVL.
A0A6M1ST56_9BACT/607-738 ..............GRSASINVWIHERSPDWDL..NMN....LGNLDLALLTAYKLKINW.N.AEMRVITVVEE-GQEEEAYKYLENLLDIARL.R.EVT..PH..VEI.GS.FTE..A...lENAPHADVDLLGL...PEEPDLNELRTYVEKTQSACVFVADSGR..ESIL.
L8LYA9_9CYAN/631-766 ..............GRVEVINLWLTPQLGEIPLseKLK....KGNLNLTMLMALRLYRSW.Q.GSLNLITVVNSNEEVPMARQYIEELRDLCRI.P.NQA.tTF..VLV.GEfNSC..I....IHAPQSDMDFIGL...PKQPNFDFICRMIDLTGSSCLFFRDSGN..ESAI.
A0A2P6C3F0_9BACT/615-747 ..............GQREQINIWIHDRSPDWSI..SMD....IGNLDLPLLTAYKLVQNW.N.AQMRLLTVVDDPSERENAQAFMETVTNLARM.P.GAD..AL..VME.GA.FRE.aV....PNAPQADLNIFGL...PPGPDFNFMRSMVDQTRSSCLFVADSGQ..ESAL.
A0A1M5R0M9_9CLOT/583-704 ..............GQEKNINLWLRDKST----..---....--NNNLAVLSAIQIMKNW.N.GSLTLCRVIDSSSDVKQVEKDLHKFIEDARL.PiNTK..IQ..VMV.GS.FSE..L....IQKEQTDLNILGM...PE--QFGEIEKIIKIIPASVLFVADSGL..ENAL.
B1WRZ6_CROS5/602-737 ..............GRMEVINLWIRPQLEDLPMieRLE....KGNTDLAILMALRLSKAW.K.AQLNIISVIPQEQDRKEAENYIDSLRDLCRI.P.ATAnsLI..IVG.EF.PSC..I....SQTPQGDMDFIGL...QSIPDFHFVHEMINMTGSSCLFMSDSGS..ESAL.
A0A371JUN3_9FLAO/597-729 ..............GQRNIINVWVSDRRSNWDL..GWD....IGNLDLCMLIAYKLKMNW.G.ARIRVITVIKNPKEKANATKFLHRLVNLARL.P.ETL..TE..VHV.GD.FNT.iV....SNAPTADLNIFGM...DADLKFEFVKTMSDKTQSSCLFARDSGH..ESIL.
H6LIP2_ACEWD/584-706 ...........lgs--ERKINIWLREKS-----..---....-RNNDLAVLSALKLVNNL.H.SEITLYRAVGHEHAKNKVEKELLGFIEEARL.PgNTQ..IK..VVT.GN.FYQ..L....IQEESADLTILGM...PG--KYEDIIKLLDTSPGSLLFVASGGF..ENIL.
A0A3B0C9A9_9FLAO/597-729 ..............GQRNIINVWVSDRKGNWSL..GWD....IGNLDLSTLIAYKLKRNW.E.AQIRLITVINDEEEYENAKEFLNSLINLARL.P.ETL..TE..IHI.GN.FRD..V...vGKASNADLNIFGM...HADLPFEFVKEMTQKTESSCLFVKDSGH..ESIL.
A0A411E8Z7_9FLAO/597-729 ..............GERNMINVWLSDRQNNWSL..GWD....IGNLDLSLLIAYKLKTNW.N.ARIRLITVISDPKEEENARNFLNSLINLARL.P.LTI..TE..VFV.GD.FKN..I...aENAPSADLNIFGM...EENLSFHFVKEMVYKTNSSCLFVKDSGH..ESIL.
A0A371QIM6_9BACT/607-738 ..............GRQASVNVWIREQSPHWDL..NMD....LGNVDLALLSAYKLKKNW.N.ADMRVITVVE-ESQVENAYQYLENLLDVARL.K.DAS..AH..VEI.GT.FEE..A...lQTAPQADVDFFGL...TKDPKLDELRSYVELTRSACVFVADSGN..ENIL.
#=GC seq_cons ..............GpcpsINlWlc-psssWcl..uhc....lGNhDLulLhAY+Lp+NW.p.AplcllsllsctpphppAppaLcpLh-lARl.P.ssp..hp..Vhh.Gs.htc..l....ppuPpADlNIFGl...sss.sh-hhcchlppTpSSCLFVtDSGp..EssL.
//
