#=GF ID CDI_toxin_EC869_like
#=GF AC PF21111.1
#=GF DE CDI toxin restriction endonuclease-like domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE ECOD:EF23239
#=GF GA 27.00 27.00;
#=GF TC 27.40 28.90;
#=GF NC 26.70 26.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0236
#=GF RC Paper describing PDB structure 4g6u
#=GF RN [1]
#=GF RM 23236156
#=GF RT Structural basis of toxicity and immunity in contact-dependent
#=GF RT growth inhibition (CDI) systems.
#=GF RA Morse RP, Nikolakakis KC, Willett JL, Gerrick E, Low DA, Hayes
#=GF RA CS, Goulding CW;
#=GF RL Proc Natl Acad Sci U S A. 2012;109:21480-21485.
#=GF RC Paper describing PDB structure 4zqu
#=GF RN [2]
#=GF RM 26449640
#=GF RT Diversification of beta-Augmentation Interactions between CDI
#=GF RT Toxin/Immunity Proteins.
#=GF RA Morse RP, Willett JL, Johnson PM, Zheng J, Credali A, Iniguez A,
#=GF RA Nowick JS, Hayes CS, Goulding CW;
#=GF RL J Mol Biol. 2015;427:3766-3784.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Contact-dependent growth inhibition (CDI) systems encode
#=GF CC polymorphic toxin/immunity proteins that mediate competition
#=GF CC between neighbouring bacterial cells [1]. Despite sharing little
#=GF CC sequence identity, the toxin domains are structurally similar
#=GF CC and have homology to endonucleases. The EC869 toxin is a
#=GF CC Zn(2+)-dependent DNase capable of completely degrading the
#=GF CC genomes of target cells [1].
#=GF SQ 102
#=GS A9EB23_9RHOB/1-109 AC A9EB23.1
#=GS A0A3A9BRU2_9BACT/248-364 AC A0A3A9BRU2.1
#=GS A0A1I7KW48_9FIRM/51-163 AC A0A1I7KW48.1
#=GS A0A6B8KF89_9HYPH/311-431 AC A0A6B8KF89.1
#=GS S0FNW4_RUMCE/221-333 AC S0FNW4.1
#=GS T0NXV2_PHOTE/355-477 AC T0NXV2.1
#=GS I3DGP9_9PAST/292-418 AC I3DGP9.1
#=GS A0A4V3WBJ6_9RHOO/2623-2745 AC A0A4V3WBJ6.1
#=GS A0A099CXY1_9GAMM/477-599 AC A0A099CXY1.1
#=GS A0A3R9M2W3_9RHOB/402-524 AC A0A3R9M2W3.1
#=GS A0A3E2YSI6_9ACTN/3010-3131 AC A0A3E2YSI6.1
#=GS J7TFW1_MORMO/1636-1758 AC J7TFW1.1
#=GS W1ITV2_9GAMM/168-290 AC W1ITV2.1
#=GS F9ERB1_FUSNU/237-349 AC F9ERB1.1
#=GS C0B230_9GAMM/544-608 AC C0B230.1
#=GS A0A1M7B6M7_9RHOB/3-112 AC A0A1M7B6M7.1
#=GS A0A318XZT8_9FIRM/236-346 AC A0A318XZT8.1
#=GS D4S6R9_9FIRM/11-124 AC D4S6R9.1
#=GS A0A1A8ZQ87_9ACTN/3130-3251 AC A0A1A8ZQ87.1
#=GS A0A4R2N1V4_9PAST/266-393 AC A0A4R2N1V4.1
#=GS A0A370IBR4_9NOCA/214-325 AC A0A370IBR4.1
#=GS A0A0B5E0T0_9RHOB/395-488 AC A0A0B5E0T0.1
#=GS A0A8B2P0I2_9HYPH/426-551 AC A0A8B2P0I2.1
#=GS I4YYR0_9HYPH/394-520 AC I4YYR0.1
#=GS A0A7W6DJG4_9SPHN/2-96 AC A0A7W6DJG4.1
#=GS A0A1G4P519_9FIRM/216-333 AC A0A1G4P519.1
#=GS A0A6I4YQB6_9PROT/333-463 AC A0A6I4YQB6.1
#=GS A0A4R2SSC0_9PAST/694-819 AC A0A4R2SSC0.1
#=GS A0A6I0FL37_9CLOT/304-413 AC A0A6I0FL37.1
#=GS A0A1Y4RGN2_9FIRM/247-363 AC A0A1Y4RGN2.1
#=GS A0A1W6MQG5_9HYPH/318-438 AC A0A1W6MQG5.1
#=GS A0A6L9Y804_9BURK/307-400 AC A0A6L9Y804.1
#=GS A0A518AKM4_9BACT/233-345 AC A0A518AKM4.1
#=GS A3TG71_9MICO/331-443 AC A3TG71.1
#=GS Q9CND7_PASMU/89-213 AC Q9CND7.1
#=GS B8I6J9_RUMCH/226-335 AC B8I6J9.1
#=GS A0A8J3E3P4_9PROT/309-417 AC A0A8J3E3P4.1
#=GS A0A517R2U1_9BACT/16-128 AC A0A517R2U1.1
#=GS A0A4P6ETB9_9MICO/8-119 AC A0A4P6ETB9.1
#=GS A0A060QL52_9PROT/848-983 AC A0A060QL52.1
#=GS A0A1I0DVG9_9FIRM/28-139 AC A0A1I0DVG9.1
#=GS A0A176QCI2_9MICO/374-491 AC A0A176QCI2.1
#=GS A0A2T0TRL3_9MICO/206-319 AC A0A2T0TRL3.1
#=GS A0A4U7JIB5_9FIRM/219-329 AC A0A4U7JIB5.1
#=GS A0A0N0ZAF2_9GAMM/1681-1804 AC A0A0N0ZAF2.1
#=GS A0A1Q4Z7C7_9ACTN/3116-3237 AC A0A1Q4Z7C7.1
#=GS A0A212Q5Z7_9HYPH/315-432 AC A0A212Q5Z7.1
#=GS A0A428JMG0_9RHOB/415-537 AC A0A428JMG0.1
#=GS D4S485_9FIRM/11-124 AC D4S485.1
#=GS A0A369Q580_9SPHI/7-96 AC A0A369Q580.1
#=GS Q7N2L4_PHOLL/1-111 AC Q7N2L4.1
#=GS A0A1V1PL65_9PROT/194-317 AC A0A1V1PL65.1
#=GS Q9K0T4_NEIMB/168-290 AC Q9K0T4.1
#=GS A0A0U5EZC0_9PROT/212-360 AC A0A0U5EZC0.1
#=GS A0A1W2DJZ4_9RHOB/3-74 AC A0A1W2DJZ4.1
#=GS A0A0A2VN69_BEABA/338-460 AC A0A0A2VN69.1
#=GS A0A086F4G6_CHRP1/570-684 AC A0A086F4G6.1
#=GS A0A3S4T6S4_9DELT/296-409 AC A0A3S4T6S4.1
#=GS H1D637_9FUSO/4-115 AC H1D637.1
#=GS A0A1C5J9F5_9ACTN/2801-2922 AC A0A1C5J9F5.1
#=GS A0A4R6DCS9_9RHOO/608-730 AC A0A4R6DCS9.1
#=GS A0A369AE59_9FIRM/1845-1954 AC A0A369AE59.1
#=GS D4S6S2_9FIRM/29-142 AC D4S6S2.1
#=GS A0A7J0BWE0_9DELT/413-535 AC A0A7J0BWE0.1
#=GS F9ES50_FUSNU/78-181 AC F9ES50.1
#=GS A0A1C5HLA9_9ACTN/3128-3247 AC A0A1C5HLA9.1
#=GS A0A120F730_9ACTN/1607-1728 AC A0A120F730.1
#=GS A0A0M6XR93_9RHOB/4-104 AC A0A0M6XR93.1
#=GS A0A017H5L0_9FUSO/177-291 AC A0A017H5L0.1
#=GS A0A4Y6VAY5_9PROT/889-1029 AC A0A4Y6VAY5.1
#=GS A0A0S2FB76_LYSAN/3288-3413 AC A0A0S2FB76.1
#=GS A0A1G5IFV8_9FIRM/461-574 AC A0A1G5IFV8.1
#=GS A0A6L9MKU1_9HYPH/350-475 AC A0A6L9MKU1.1
#=GS A0A511X8U6_9PROT/259-401 AC A0A511X8U6.1
#=GS A0A3G8ZUE5_9ACTN/2207-2311 AC A0A3G8ZUE5.1
#=GS A0A3N1D034_9ACTN/2524-2636 AC A0A3N1D034.1
#=GS A0A1H5YGE6_9RHOB/402-524 AC A0A1H5YGE6.1
#=GS S9R1Y2_9DELT/992-1106 AC S9R1Y2.1
#=GS A0A0Q9ZXT8_9GAMM/2980-3102 AC A0A0Q9ZXT8.1
#=GS A0A1V4SQW0_RUMHU/225-336 AC A0A1V4SQW0.1
#=GS C0B223_9GAMM/1-40 AC C0B223.1
#=GS A0A0P6WWC0_9SPHN/4752-4867 AC A0A0P6WWC0.1
#=GS A0A1I0M0S2_9FIRM/211-326 AC A0A1I0M0S2.1
#=GS F9EQ08_FUSNU/1-80 AC F9EQ08.1
#=GS A6VN29_ACTSZ/601-725 AC A6VN29.1
#=GS A0A4R3HWS6_PAULE/5669-5791 AC A0A4R3HWS6.1
#=GS T0P0I4_PHOTE/317-439 AC T0P0I4.1
#=GS A0A251W7Z6_9CYAN/2361-2479 AC A0A251W7Z6.1
#=GS A0A0U5BDH8_9PROT/101-238 AC A0A0U5BDH8.1
#=GS A0A553DT11_9FLAO/1-83 AC A0A553DT11.1
#=GS A0A1V4SEE9_RUMHU/312-410 AC A0A1V4SEE9.1
#=GS A0A1V9F5W1_9BACT/1-80 AC A0A1V9F5W1.1
#=GS D3R2H4_MAGIU/198-321 AC D3R2H4.1
#=GS A0A1G5MBN3_AFIMA/409-531 AC A0A1G5MBN3.1
#=GS A0A6L9H952_9CLOT/257-375 AC A0A6L9H952.1
#=GS C0B226_9GAMM/1-77 AC C0B226.1
#=GS F4L2C9_HALH1/146-267 AC F4L2C9.1
#=GS A0A443IDC5_9GAMM/462-584 AC A0A443IDC5.1
#=GS A0A1V4SKD0_RUMHU/557-677 AC A0A1V4SKD0.1
#=GS A0A4R2N1S1_9PAST/1-39 AC A0A4R2N1S1.1
#=GS A0A2P1P9J3_9RICK/1-79 AC A0A2P1P9J3.1
#=GS A0A0U5EYK4_9PROT/101-238 AC A0A0U5EYK4.1
A9EB23_9RHOB/1-109 .................mg----------.--..----E.........RTP...DNFK...TFDFF..DE.DR.GL..A...TSAKTLETRAP....G.......YV..DR.....P......SRIFGALKRYIDQID.HFEY.....D...........N..........K....K..G...I...........E....I...S...A.D.EIDIKRLELAV.P.D.G........T.TPEQF..TQIQRAIDYA...ESLGIDVEV-s.......................
A0A3A9BRU2_9BACT/248-364 .........naiqeqegvr----------.--..-----.........NLP...NHFP...AYSAY..DS.AS.GK..A...TAECSIDLR-D....A.......SY..QN.....V......SGIKAAISRECKKME.NFQD.....T...........T..........Y....D..G...V...........T....L...K...R.D.DIKSRELVIYI.P.S.S........K.GGR--..----------...----------eidrasydqavkeirekypdiqit
A0A1I7KW48_9FIRM/51-163 ............nviddal----------.--..---GN.........NLG...HNYP...TIDKF..E-.-D.GI..V...TSFKSRDLSS-....V.......TY..QN.....A......SRLEYQIKKDIDALN.DFTD.....T...........S..........W....N..N...V...........V....I...T...E.N.MIKARRLQIVI.S.DtE........L.TAQQI..DAFNNSIEYA...KEKGIDIIIT........................
A0A6B8KF89_9HYPH/311-431 ...................QGGPWEDYLA.GS..LPGAR.........KLP...ANAK...TFDLF..NP.LT.QE..A...VSAKTLNTLSV....S.......YI..RK.....P......ESIYGKLKRYTDAAA.DYAP.....R...........R..........-....-..K...R...........D....L...D...P.D.LIRSKAIHLAI.S.E.Y........T.SPVQW..RQLRRARRYA...REKGIPLVIT........................
S0FNW4_RUMCE/221-333 .............qeirkl----------.--..--QGA.........NLP...FNFP...TVAKY..G-.-N.GT..V...TSIKSLNIE-E....A.......YY..KD.....P......VNLEKKITSYINKLK.EFNG.....G...........T..........C....G..E...V...........S....I...R...S.S.DIFRKELLLII.P.EiE........L.ASNQQ..SVIDKCIGLA...ESRGITLK--pv......................
T0NXV2_PHOTE/355-477 ...................QGYPFEDFVA.TQ..MPKDS.........RLP...KNFE...VYDFY..DG.KT.GI..A...TSVKTLDTRTA....A.......RI..KD.....P......KQLYSSIKRNIDDAS.NFTE.....G...........S..........K....G..T...K...........I....I...D...S.S.MISQREVRIAV.P.K.T........T.TPDQW..EQINRAITYG...TEKNINVKIT........................
I3DGP9_9PAST/292-418 ...................QGKAWEEYLQtTS..LPEGTln.....lnEIK...PNFK...TFDHL..L-.PD.GT..A...VSAKTMDTVGS....K.......TY..QD.....P......KRITHQLNKYVDDMV.NFKG.....D...........G..........K....G..F...D...........R....I...Y...N.K.DISSKEMYLAI.P.F.G........S.TKEQW..NAINKSIDYA...QSQGVKIIVK........................
A0A4V3WBJ6_9RHOO/2623-2745 ...................QGMPWEDYLA.SQ..LPSGT.........RLP...QGFK...TFDFY..DA.ST.GT..A...ISAKTLDTTTA....A.......KI..AN.....P......NQIYSSLKGNVDAVA.NFDS.....Y...........A..........L....N..N...V...........P....L...N...K.N.MIGVRELYVAV.P.S.G........T.TSAQW..VQINRAIEYG...KSQGVNVVI-s.......................
A0A099CXY1_9GAMM/477-599 ..................p-GYTWESYVL.RK..QDLTA.........PPT...NNFK...TFDGF..DF.SC.GL..A...VSCKAMNLEMP....G.......YT..NN.....P......SSVYYTLKKYVDAAV.NFTR.....D...........E..........K....A..G...F...........K....V...L...G.E.QVPNRTIELAV.S.P.N........P.TPAQL..QQLQRAMDYA...KQNHINLNI-r.......................
A0A3R9M2W3_9RHOB/402-524 ...................QGEPWEDLLE.AG..GDHGL.........RSP...PTFP...TFDFF..DF.DS.RL..A...TSAKTLDTRAP....T.......YA..DR.....P......SRIFGRLRDYIDRIE.RFEQ.....G...........S..........S....G..V...F...........R....I...R...P.G.QIERRRLELAV.P.F.D........T.TPEQA..IQIQRAIDYA...IDRGIEVNV-r.......................
A0A3E2YSI6_9ACTN/3010-3131 ..........nqferglai----------.-E..AKLGG.........NLP...RSFP...TIDRF..A-.-N.GT..A...TSIKSVDLTAK....S.......-Y..QS.....A......GQLTSRLQGYVDKAA.GFAK.....S...........N..........Pv.twD..G...V...........T....I...K...P.G.QVAVRELEIAV.Q.R.G.......aA.TSAQQ..NALNQIVQYG...AQKGVTVRI-i.......................
J7TFW1_MORMO/1636-1758 ...................QGMPFEHYIG.TQ..LPPGS.........KLP...DGFK...TFDYY..DS.KD.KI..A...ISVKTINTQTD....S.......RL..NK.....P......DAIKYIINGHVNKIA.QFKN.....Y...........S..........M....D..D...V...........P....L...R...T.D.NIKKRVLHIGL.P.E.K........T.TPEQW..KSINSAIKNA...NDKNVDIKIT........................
W1ITV2_9GAMM/168-290 ...................QGMPWEDYVG.KA..LPTDA.........RLP...KNFK...TFDYY..DG.AT.KT..A...ISAKSMDTQTM....A.......KL..AK.....P......NQIYSSIKGNIDAAA.KFEK.....S...........A..........L....S..G...Q...........Q....I...N...S.S.MISHREIQLAV.P.A.N........T.TKTQW..IEINRAIEYG...KSQGVTVKVT........................
F9ERB1_FUSNU/237-349 ............idealkn----------.--..-----.........NLG...RTFK...TFDEY..DD.VT.KT..A...TSVKSIDLD-S....K.......TY..TS.....G......SGLSSKLNSNLKDIK.DFTE.....Y...........E..........L....G..D...I...........Y....L...S...K.D.MIDKNVLKLVI.N.N.K........PlNKSQM..ENLKKVVDNA...TKEGIKV---eai.....................
C0B230_9GAMM/544-608 ...................QGMTFENYIG.LS..NKRLT.........RLH...LNAK...TFDYY..DG.NT.GE..Y...ISVKTLNTQTA....S.......RI..KK.....S......K-INRKYI-------.----.....-...........-..........-....-..-...-...........-....-...-...-.-.-----------.-.-.-........-.-----..----------...----------kyiyf...................
A0A1M7B6M7_9RHOB/3-112 ................glg----------.--..----E.........RTP...DNFK...TFDFW..DG.DA.GI..A...TSAKTIDTRAP....G.......YV..DR.....P......SRLYGALKRYIDQID.SFEY.....D...........N..........K....K..G...I...........E....I...N...A.D.DITLKRLELAV.P.D.G........T.TPEQF..TQIQRAIDYA...ESLGIDVNV-r.......................
A0A318XZT8_9FIRM/236-346 ...............irkl----------.--..--QGA.........NLP...FSFP...TIAIF..S-.-N.GK..A...VSIKSLNTE-E....A.......YY..KS.....S......DNLKKKLLMYIDKLE.KFEG.....G...........K..........S....S..E...I...........T....I...E...G.M.QVCIRELRLII.P.E.A........ElLSNQQ..QAINECIKTA...QGKGINLKV-i.......................
D4S6R9_9FIRM/11-124 ..........gdmiddalg----------.--..----N.........NLG...HSFP...KIDKL..D-.-N.GV..A...VSIKSIKLS-D....K.......TY..ET.....A......KGIYNKLRRDVDALD.EFKE.....A...........A..........D....K..K...R...........N....I...S...P.K.DYSAKKLEIAV.QdM.K........I.TAEQQ..RGLEMVKEYA...KEKGIEISIT........................
A0A1A8ZQ87_9ACTN/3130-3251 ..........nqferglai----------.-E..AKLGG.........NLP...RSFP...TIDRF..A-.-N.GT..A...TSIKSVDL-TA....K.......TY..QS.....A......SQLSSRLTGYVDKAA.GFAK.....N...........N..........Av.twD..G...V...........T....I...R...P.G.QVAARELEIAI.P.R.G........TaTAAQQ..NVLNQIVQYG...ASKGVTVRV-i.......................
A0A4R2N1V4_9PAST/266-393 ...................QGYPWEQYLM.SY..LPEGTtn.....lnKIK...SNFK...TFDHL..L-.PD.GT..A...VSAKTMDTIGS....K.......TY..QN.....P......KRITSQLNKYVDDMV.SFDR.....D...........S..........Kq..gT..E...F...........I....L...E...N.E.DIVSKELYLAI.P.N.G........T.TKQQM..NAINESVRYA...DSQGVKIIVK........................
A0A370IBR4_9NOCA/214-325 ............rkkptpm----------.--..-----.........---...----...TSDSF..RI.EG.GT..A...IQVKTLQNSSD....A.......-Y..QK.....P......NAVRKVLNEYVEQLF.NFEReislnE...........R..........R....G..A...E...........V....YhaeH...S.G.EVDRKILHVEL.D.S.E........P.TATQL..VDLEKIRESC...EHNGIE----fiy.....................
A0A0B5E0T0_9RHOB/395-488 ..rglsyerslaeradgeg----------.--..--RGT.........WLE...KEFRdhpGVDFF..DF.AT.GQ..A...TSVKTLDLNAY....T.......YR..TS.....P......SQIYGTLSRYVRDLA.EFEG.....G...........E..........-....-..-...-...........-....-...-...-.-.-----------.-.-.-........-.-----..----------...----------glirreevrlrtsv..........
A0A8B2P0I2_9HYPH/426-551 ...................QGDPWERHLA.EQ..GVLGDw......lgERA...PNLK...TFDFF..SR.NS.RV..A...IIGKTLNTAAP....G.......YT..RR.....P......RSIFSRIKGYLDEIA.EFEG.....D...........D..........R....K..G...Y...........R....I...R...Q.G.EIELRRMELAI.P.S.R........T.TAEQM..DEINRARTYA...ESLGIELEVT........................
I4YYR0_9HYPH/394-520 ...................QGMPWKDYLA.GQ..LPKGS.........RLP...ANFK...TFDFF..DE.AS.GV..A...TSAKTLDTMTA....A.......KL..AD.....P......KQVYYSLKANIDDMA.NYNK....tY...........R..........L....D..N...R...........S....V...D...P.N.HIEVRQLQVAV.P.A.G........T.TSAQW..EQINRAVEYAagnNMQSVKLIVT........................
A0A7W6DJG4_9SPHN/2-96 ...............idrf----------.--..-----.........---...----...-----..E-.-N.GL..A...TSIKSIDLD-A....A.......TY..QS.....G......STLTRTLNGYVDKVA.GFQG.....R...........T..........W....A..G...V...........R....I...R...G.Q.DITGRALDLAI.P.H.S........G.SAAQQ..AIISQTVKYG...ASRGVTVNV-i.......................
A0A1G4P519_9FIRM/216-333 ...........rgdffren----------.--..--ASS.........NLP...KTFP...VIDSY..N-.-G.GT..C...ESVLSIDLT-A....P.......YY..SN.....D......GRVMKTVKAEIDDLA.GFDG.....A...........D..........VvisgQ..R...Y...........V....V...S...G.Q.DIRARRLNVVI.P.S.N........S.PETSR..AVVSSLTEYA...RINGVDLNIT........................
A0A6I4YQB6_9PROT/333-463 ...................QGNPYEVWVS.QK..LEPKGyl....wlaDYK...NNWK...AFDQW..NQ.NT.HD..A...VSDKTIDLQAK....S.......YA..NN.....P......IRVEARILANIGQMI.HYQN.....Df........gtA..........L...rS..G...V...........PplldV...S...K.T.SIGSYTLSLGV.P.S.E........P.TEEQW..EALCKAYQIG...E---------grva....................
A0A4R2SSC0_9PAST/694-819 ...................QGKAWESYLQ.QT..LPEGTld.....lnSIK...SNFK...AFDHL..L-.PD.GT..A...ISAKTMDTVGA....K.......TY..KD.....P......KRITYQLNKYVDDMV.NFKS.....D...........G..........K....G..D...F...........I....I...N...N.Q.NIKTKEMYLAI.P.H.G........T.TKKQF..EAINKSVNYA...ESLGVKIIVK........................
A0A6I0FL37_9CLOT/304-413 ..............ikkll----------.--..---NS.........NLD...ENFP...IIDSY..RD.RT.VE..A...--IRSHDTRLI....S.......--..NE.....G......RGFYYQLTSSIRELD.EFTG.....R...........K..........Y....K..G...K...........A....I...T...P.E.DYSKKQLTIVV.P.DvE........V.TEEQI..KSIRDAMTYG...ADREIII---rlv.....................
A0A1Y4RGN2_9FIRM/247-363 ........gkliqeqqnvr----------.--..-----.........NLP...DQFP...AFSAF..DP.AT.GT..A...TAEVSIDLRAK....S.......-Y..QT.....T......AGIVGTIRSQCSDME.NYRT.....S...........T..........R....E..Q...V...........T....V...N...E.E.EIREKVLIVYI.P.S.S........T.GDRTI..----------...----------drsaydqavnevqeaypdiri...
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F9EQ08_FUSNU/1-80 ..................m----------.--..-----.........---...----...-----..--.--.--..-...---------TS....K.......TY..TS.....G......SGLSSKLNSDLKDIK.DFTE.....Y...........E..........L....D..K...V...........K....L...E...N.K.DIEVRVLKIVI.N.N.K........PlNKSQM..ENLKKVVEHV...TEDGIKV---eav.....................
A6VN29_ACTSZ/601-725 ...................QGKAWESYLQ.TI..LPEGTid.....lnSIK...PNFK...AFDHL..L-.PD.GT..A...VSAKTMDTV--....G.......GY..KN.....P......RRITSQLNRYVDDMV.KFQQ.....D...........G..........K...rG..G...R...........V....I...S...S.E.QILSKEMYLAI.P.Y.G........T.SKEKI..QAINKSVDYA...KIQGVKLIVK........................
A0A4R3HWS6_PAULE/5669-5791 ...................QGMPWENYLS.TQ..LPAGS.........RLP...TNFK...TFDFF..DD.IS.GT..A...ISAKTLNTTTA....A.......KL..AK.....P......EQTFTSLKANIDAAA.NFES.....Y...........T..........L....K..G...V...........S....L...S...S.G.DIAARQVQVAV.P.R.V........T.TDAQW..QQIQRAIQYG...QSKNVQVVVT........................
T0P0I4_PHOTE/317-439 ...................QGIPWEDYVG.TQ..LPVDA.........RLP...KNFK...TFDYY..DG.VT.KT..A...ISVKTMDTQTL....S.......KL..TK.....P......NQIYSSLKGNIDAAS.LFKT.....Y...........T..........L....L..D...R...........K....L...N...T.S.MIANREIRLAV.P.A.N........T.TKAQW..SEINRAIEYG...INQGVKVTVT........................
A0A251W7Z6_9CYAN/2361-2479 ..............pyfgh----------.--..-----.........NTP...PSFR...GVDTF..IR.NT.GD..V...TSIKSLDPLKMdlntG.......RLfpKS.....G......NEIQRTLEKYIDDLD.KFQGa...tH...........K..........K....S..G...F...........T....I...E...S.S.DIKQKWLEVIT.R.P.D........L.TTDQI..AAFSEAAQLA...SDKGII----fmln....................
A0A0U5BDH8_9PROT/101-238 ...................QGNPFEVWDA.QR..LKDQGydwl.adyqTPK...SNWK...SFDEW..NN.NS.RT..A...ISDKTMDLG-A....P.......YY..KI.....Q......RNIQARILANVQQMI.RYDT.....D...........SgpyryndgssKv..gT..S...V...........E....F...S...K.T.EINHYVLDLGV.P.S.D........P.TDDQW..QAICKALQRA...KDR-------vam.....................
A0A553DT11_9FLAO/1-83 .................md----------.--..-----.........---...----...-----..--.--.--..-...-------L-TA....T.......SY..QK.....G......NSVLNTLKGYVDSLS.SFSS.....K...........T..........W....G..G...T...........A....V...T...QgE.SYTSKALELAV.Q.SgK........G.SEAQW..GQINQAIQYA...LDKDINVTI-r.......................
A0A1V4SEE9_RUMHU/312-410 .......frngkgylsdik----------.--..-----.........---...----...-----..--.--.--..-...-SIKSIDI-TA....K.......TY..QK.....S......SNLKSLLKGYVNDLA.NFSE.....A...........K..........F....E..K...V...........N....Y...Y...V.M.DGTSRTLEIAI.P.AvE........M.TADQA..KVFKYITDYA..kSEKNINVVVK........................
A0A1V9F5W1_9BACT/1-80 ..........mgaksyiga----------.--..-----.........---...----...-----..--.--.--..-...-----------....-.......--..--.....-......GKVFDVLKGYIDVLM.QFKG.....G...........S..........R....A..G...V...........I....I...K...E.A.DITSKVLQVAIkP.F.G........T.SLMQW..VEIAKAWQYA...YKNNIG----fqlr....................
D3R2H4_MAGIU/198-321 .....dwhnfkrgaylreq----------.--..--NGG.........NLP...HNYP...VISRF..K-.-S.GE..A...TMIKSIDLT-A....P.......TW..QN.....P......DNITEQASRMVKNLA.GFNG.....Tpe.......lwG..........K....D..R...I...........S....I...R...N.G.DIKSRKIIIVV.P.E.N........S.PPQAL..AALRNALAAG...AGQGV-----fyeii...................
A0A1G5MBN3_AFIMA/409-531 ...................QGIPWEDALE.AT..GQFGQ.........RLP...QNFK...TIDFY..DP.VK.RT..A...TSAKTLYTRAA....G.......YV..ED.....P......EKIYRTLQRYTDHLA.SFDG.....D...........R..........K....K..G...L...........S....V...K...S.S.EIEVKRIELAV.P.M.D........T.SRQQI..VKIRRAVRYA...EQHGVQLRVT........................
A0A6L9H952_9CLOT/257-375 ..........eaiqdmeqv----------.--..----R.........NLP...KGFK...TFSAF..DE.GS.GK..A...TAERSVDLRED....S.......-Y..RD.....E......NGIAGTIRKKCNDMI.NYRD.....H...........T..........Y....G..G...V...........T....L...R...K.D.DIRSMELILYI.P.S.S........T.KDRNIdrSAFDKAVQKV...----------krdypeisivvk............
C0B226_9GAMM/1-77 ..................m----------.--..-----.........---...----...-----..--.--.--..-...-----------....S.......KL..NR.....P......KQIYNTIKGNIDDVA.KFEG.....H...........R..........L....S..G...V...........N....L...H...S.E.MIAKREIWLAV.P.Q.S........T.TKAQW..IEINRAVAYG...KSMNIEIKIT........................
F4L2C9_HALH1/146-267 ......qieaslingfndg----------.--..-----.........-WP...NNFP...VIDGY..DA.AT.GT..A...ISIKSIDLNAK....-.......TY..QN.....L......AALENRLMDYFRKLR.DFTR.....E...........Q..........R....G..L...I...........D....I...GdplR.T.PINFKELVLAV.P.R.Q........P.TAAEQ..AIINKVINSA...----------mgltppisirvt............
A0A443IDC5_9GAMM/462-584 ...................QGMPWEDYVG.KS..LSADA.........RLP...QNFK...TFDYY..DG.AT.KT..A...VSAKSMDTQTM....A.......KL..GN.....P......NQVYSSIKGNINAAA.KFER.....S...........E..........L....S..G...Q...........V....L...N...S.S.MIANREIQLAV.P.A.N........T.TKAQW..VEINRAIEYG...KSQGVKVTVT........................
A0A1V4SKD0_RUMHU/557-677 .....gwlergniidklrg----------.--..----N.........GLG...HNFP...VIDKL..E-.-N.KV..A...VSIKSLDTA-A....A.......TY..QN.....S......SALLSKLNSFVYQLS.RFDG.....A...........T..........Y...gG..K...S...........A....F...Q...G.V.DFSSKALELVI.P.DvQ........L.SMEQI..QAIIKAKEYA...NSLEIGFKI-ii......................
A0A4R2N1S1_9PAST/1-39 .................mt----------.--..-----.........---...----...-----..--.--.--..-...-----------....-.......--..--.....-......---------------.----.....-...........-..........-....-..-...-...........-....-...-...-.-.---GKELYLAI.P.N.G........T.TKQQM..NAINESVRYA...DSQGVKIIVK........................
A0A2P1P9J3_9RICK/1-79 .................mg----------.--..-----.........---...----...-----..--.--.--..-...----------A....K.......TY..QN.....A......TKLEYVIRKDIDRLV.KFNK.....G...........E..........L....G..K...Y...........Q....I...E...P.H.HIQSKVLEIAV.P.D.L........G.SFSQQ..MTLNKRVNYG...KSVGIDVKI-i.......................
A0A0U5EYK4_9PROT/101-238 ...................QGNPFEVWDA.QR..LKDQGydwl.adyqTPK...SNWK...TIDEW..QA.SS.GI..A...VSDKTIDMGAK....S.......-Y..QV.....M......RNIQGRLLANVQDMI.RYES.....DlgpyryndgsdK..........V...gT..S...L...........Q....V...T...Q.T.QIKHFSLDLGV.P.V.E........T.TNEQW..EAICKALQRA...KER-------vae.....................
#=GC seq_cons .....................................ts.........pls...tsF....shDha..s...s.Gs..A...sShKolDhpss....s.......hh..ps.....s......splhppLpt.lcphs.pFps.....s...........p..........h....s..s...h...........s....l...p...s.s.pIpp+pLclul.P.p.s........s.ospQh..ttlpcslpYu...pppGlpl.l.........................
//
