#=GF ID   CEL_III_C
#=GF AC   PF18054.5
#=GF DE   CEL-III C-terminal
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF03964
#=GF GA   27.00 27.00;
#=GF TC   27.10 27.70;
#=GF NC   24.20 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15194688
#=GF RT   Crystal structure of the hemolytic lectin CEL-III isolated from
#=GF RT   the marine invertebrate Cucumaria echinata: implications of
#=GF RT   domain structure for its membrane pore-formation mechanism.
#=GF RA   Uchida T, Yamasaki T, Eto S, Sugawara H, Kurisu G, Nakagawa A,
#=GF RA   Kusunoki M, Hatakeyama T;
#=GF RL   J Biol Chem. 2004;279:37133-37141.
#=GF DR   INTERPRO; IPR041014;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the C-terminal domain found in Cucumaria echinata
#=GF CC   CEL-III protein which is a lectin that exhibits both hemolytic
#=GF CC   and hemagglutinating activity. The domain is responsible for
#=GF CC   oligomerization and insertion of CEL-III into the erythrocyte
#=GF CC   membrane. The domain is composed of eight stranded beta sandwich
#=GF CC   and two alpha helices, the latter changes conformation upon
#=GF CC   binding to the cell surface carbohydrates [1].
#=GF SQ   8
#=GS A0A0D8CIP6_9PROT/289-447  AC A0A0D8CIP6.1
#=GS A0A0P1EQT4_9RHOB/285-446  AC A0A0P1EQT4.1
#=GS A0A078ABI8_STYLE/65-211   AC A0A078ABI8.1
#=GS A0A0B3S9Q7_9RHOB/253-406  AC A0A0B3S9Q7.1
#=GS A0A0J9E5R2_9RHOB/386-523  AC A0A0J9E5R2.1
#=GS A0A222E072_9RHOB/253-406  AC A0A222E072.1
#=GS J9J1X2_9SPIT/193-337      AC J9J1X2.1
#=GS A0A4R3N0Y0_9GAMM/301-455  AC A0A4R3N0Y0.1
A0A0D8CIP6_9PROT/289-447             .........vy--GQWKQKQ..TC.FGNACgS.LSATVSRGVSTTDSWEKTDSYGQSITTKIESGeLPILGGG-KVSAEAGLTFSQTSSWSSASTTEIKNGFEVQC.......NfgSVSDTSF.GEMWQFETISSSQCLDKITCSGSIEVLDYMCIvwKEIPKEMNPP.VCLPGYCKNNACTEC...............................
A0A0P1EQT4_9RHOB/285-446             .........se--GKWSLVA..RC.TGTSC.KeLRRSISFGTSKTDTWSTQHQWGVVVTNSIEAE.FGIFGTSSKVSASVAASYAQSQEFQQALNTSQTSTLTAICtfeessdN..PEENVKT.GEMYQFLTGTEAVCTEGGACKSQTYTADHACI..ADPASDYAGP.QCIPGYCANADCSEC...............................
A0A078ABI8_STYLE/65-211              ........lrg---EWVKRF..S-.-TSNG.K.ISSQLTIGITQETSETKSKTFGASLEAAASSG.VSFLGSGAEITVTASASASMASEITSSLGTSRTTQSTVEC.......D.qASGRQSS.LWQWRLRGTKGDKVLLSYDS------EDYVCK..--YGSDYLTPpKCPLGSCSDTEC---rgsc...........................
A0A0B3S9Q7_9RHOB/253-406             ...........TVGRWEKVI..SC.DGKNC.P.ISHEISVGTTKTNSWTTTQQWGITVTESMEAG.LTILGTGVKASASISQSYAASFAFTSALSKSVTQNYTATC.......D..PSGEYSS.RALWQFSTGTGETCLESGTCDGATFTAEYLCV..GDAPGDYVGP.ACIPGYCADELCTVC...............................
A0A0J9E5R2_9RHOB/386-523             dghweaatppc---------..--.--PSC.PeIDYQVSYGVEEGKETSSESSFGIEISLSVEED.DEILGTGVSAEQSISSSASFSSAVAESFSRSKTEDITVPC.......H..LG-----.-QVWQWVSVATRDCAFG---------------..----------.---------------vqcpaitarssviqctvpgdepihdpswspc
A0A222E072_9RHOB/253-406             ...........TVGRWQKVI..SC.DGLNC.P.ISHQISVGTERTNSWTTTQQWSVTVTESMEAG.LTIFGTGVKASASVAESYAGSYAYSSALSQSVAQNYTATC.......D..PSGSYTS.RALWQFSTGTGTSCLESGTCDGSTFTAEYLCV..GDAPSGYTGP.VCIPGYCADELCSTC...............................
J9J1X2_9SPIT/193-337                 ........vnt---FWERVI..SS.N---G.P.ITETIEVGWSKEDSKTDEVTVSQSFTASAEEG.YTFMGSSGKASLSYTLSSSIRQAVTSSLSISKRVSKTVSC.......N.nPNNEL--.VTLYQWVLDGQRIGQPSILVDDSNFICRYGVN..AN-----SSP.ACPLTMCADSQCNTC...............................
A0A4R3N0Y0_9GAMM/301-455             ........tfv---AWQKVAefKCaKGAEC.D.LSYALAYGSSSKNYFTKTTEWAEWVTNSVGLG.V----VGIKASVEASANYGDSENFQNALNVEYGQKTTINC......vE..NKSPYAYhLVLYQFETQTDITCILSGDCSTVTQTMDTFCA..VNPPDGYQGP.QCLPGDCADEFCYTC...............................
#=GC seq_cons                        ..........h...pWp+Vh..oC.pGssC.s.ISpplShGsocssSaTsoppaGholTsShEuG.lsIhGoGsKASsSsotSautSpuaoSALopShspshTlsC.......c..ssuphs..htlWQFpTsospsCl.ShsCssss.st-YhCh..ss.sssYsuP.tClPGhCADp.CspC...............................
//