#=GF ID   CMV_1a
#=GF AC   PF12467.12
#=GF DE   Cucumber mosaic virus 1a protein family
#=GF AU   Gavin OL;
#=GF SE   Prosite
#=GF GA   25.00 25.00;
#=GF TC   29.00 29.00;
#=GF NC   24.30 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15305604
#=GF RT   The necrotic pathotype of the cucumber mosaic virus (CMV) ns
#=GF RT   strain is solely determined by amino acid 461 of the 1a protein.
#=GF RA   Diveki Z, Salanki K, Balazs E;
#=GF RL   Mol Plant Microbe Interact. 2004;17:837-845.
#=GF DR   INTERPRO; IPR021002;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain family is found in viruses, and is typically between
#=GF CC   156 and 171 amino acids in length. The family is found in
#=GF CC   association with Pfam:PF01443, Pfam:PF01660. 1a protein is the
#=GF CC   major virulence factor of the cucumber mosaic virus (CMV). The
#=GF CC   Ns strain of CMV causes necrotic lesions to Nicotiana spp. while
#=GF CC   other strains cause systemic mosaic. The determinant of the
#=GF CC   pathogenesis of these different strains is the specific amino
#=GF CC   acid residue at the 461 residue of the 1a protein.
#=GF SQ   5
#=GS 1A_TAV/447-610        AC P28931.1
#=GS I7GUN6_9BROM/420-541  AC I7GUN6.1
#=GS 1A_PZSVT/429-597      AC Q9DUT3.1
#=GS 1A_CMVQ/448-609       AC P06011.1
#=GS 1A_CMVFN/448-610      AC P17769.2
1A_TAV/447-610                   .............f-IRKFFASL--TRPMRVFLSACVKTLFPTL-RPRDEKEFLVKLS---TFVTFNEVCQVDLDAEWDVISSAA--------FTAEMAVEDGKRLAED-RKQKAEA-----ASQIPVDEIPDDtAESSDDTPREADTNQKSEPSSPELETLSTQTRSPI-TRLAQRASSMLEYSAYEAQLHDNAVSNL......................
I7GUN6_9BROM/420-541             wnhctgwwsestkf-------------------QDFLAVCFPSLLDYYHSKVFVEKISECVVFE--SELAALEGSKSWS--DDAYNILNNNLLLCALALSKCKEHKPEK--EKEKEE--VLAVPSKA-------.----------------------------------------------------------------tptlvevkeeekldtpiiavdr
1A_PZSVT/429-597                 ..............WVSHFFKSLWPSGDLRDLFGR----YFPSLIRYYDKIEFVEKLTHCEVFV--NELGMTDDKEQRDVVAEAADVLKNTLLKVAIKMSLDKTFRPAE--EKKEERTTTTTVTSSAVGDVDER.PAGTVSGPTIQAPSVTQENTVTSLS-------EPLDGRLAVRLEAMKEYKRYLLKLQKNTESNL......................
1A_CMVQ/448-609                  ...........fiw---KWFASM--SRPFRVFFSTVVKTLFPTL-RPREEKEFLVKLS---TFVTFNEECSFDGGKEWDVISSAA--------FVATQAVADGTILAEEKAKKLADR------LAVPVEEVTAI.PEVS-PTPVDQGTACGLETETSELDSLSAQTRSPI-ARIAERATAMLEYSAYEKQLHDTTVSNL......................
1A_CMVFN/448-610                 .............s-ISKWFAAL--TRPLRVFFSSVVHALFPTL-RPREEKEFLIKLS---TFVTFNEECSFDGGEEWDVISSAA--------YVATQAVTDGKILAAQKAEKLAEK------LAQPVSEVSDS.PETSSQTPDDTADVCGREREVSELDSLSAQTRSPI-TRVAERATAMLEYAAYEKQLHDTTVSNL......................
#=GC seq_cons                    .............a.lpKaFASL..oRPhRVFFSssV+sLFPTL.RPR-EKEFLlKLS...TFVTFNElCuhDGucEWDVISSAA........aVAppAVpDGchLAE-.tEKcAE+.....ssupPVsEVs-p.PEsSssTPs-pusssspEspsoEL-oLSsQTRSPI.sRlApRAoAMLEYuAYEtQLHDsTVSNL......................
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