#=GF ID CRA
#=GF AC PF06589.15
#=GF DE Circumsporozoite-related antigen (CRA)
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_19386 (release 10.0)
#=GF GA 26.60 26.60;
#=GF TC 27.90 26.80;
#=GF NC 26.20 25.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 8050527
#=GF RT Plasmodium falciparum: exported protein-1, a blood stage
#=GF RT antigen, is expressed in liver stage parasites.
#=GF RA Sanchez GI, Rogers WO, Mellouk S, Hoffman SL;
#=GF RL Exp Parasitol 1994;79:59-62.
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of several circumsporozoite-related antigen
#=GF CC (CRA) or exported protein-1 (EXP1) sequences found specifically
#=GF CC in Plasmodium species. The function of this family is unknown.
#=GF SQ 49
#=GS A0A1A8XGC4_9APIC/1-105 AC A0A1A8XGC4.1
#=GS A0A0L1IAR5_PLAFA/2-132 AC A0A0L1IAR5.1
#=GS A0A1D3JCN4_9APIC/2-151 AC A0A1D3JCN4.1
#=GS A0A1A8WRG8_9APIC/2-151 AC A0A1A8WRG8.1
#=GS A0A1D3THZ1_9APIC/1-105 AC A0A1D3THZ1.1
#=GS Q7RLY3_PLAYO/2-123 AC Q7RLY3.1
#=GS A0A509AQ14_PLABA/2-104 AC A0A509AQ14.1
#=GS A0A0L0CW34_PLAFA/2-132 AC A0A0L0CW34.1
#=GS K6UDF1_PLACD/1-106 AC K6UDF1.1
#=GS W4IU23_PLAFP/1-108 AC W4IU23.1
#=GS A0A024X986_PLAFC/2-132 AC A0A024X986.1
#=GS Q7RI01_PLAYO/2-151 AC Q7RI01.1
#=GS A0A384LP13_PLAKH/1-106 AC A0A384LP13.1
#=GS A0A024W4Z2_PLAFA/1-108 AC A0A024W4Z2.1
#=GS A0A0L7KLW0_PLAFX/1-108 AC A0A0L7KLW0.1
#=GS A0A1A8YK68_9APIC/2-154 AC A0A1A8YK68.1
#=GS A0A024WQD4_PLAFA/1-108 AC A0A024WQD4.1
#=GS W7JTD3_PLAFO/1-108 AC W7JTD3.1
#=GS A0A024VS38_PLAFA/454-583 AC A0A024VS38.1
#=GS Q7R7H8_PLAYO/2-130 AC Q7R7H8.1
#=GS W7K608_PLAFO/9-81 AC W7K608.1
#=GS A0A1A8YUQ5_9APIC/1-105 AC A0A1A8YUQ5.1
#=GS A0A1C3KCK0_PLAMA/26-106 AC A0A1C3KCK0.1
#=GS W7JLS6_PLAFA/1-108 AC W7JLS6.1
#=GS Q7RGC6_PLAYO/2-107 AC Q7RGC6.1
#=GS A0A679L6W5_PLAKH/2-148 AC A0A679L6W5.1
#=GS A0A0L7M439_PLAF4/1-52 AC A0A0L7M439.1
#=GS A0A2N0Z4M0_9BACI/21-110 AC A0A2N0Z4M0.1
#=GS A0A024W8Z7_PLAFA/2-132 AC A0A024W8Z7.1
#=GS A0A1Y1JD46_PLAGO/2-142 AC A0A1Y1JD46.1
#=GS Q8IIF0_PLAF7/1-108 AC Q8IIF0.1
#=GS A0A024X652_PLAFC/1-108 AC A0A024X652.1
#=GS A5K5F2_PLAVS/2-143 AC A5K5F2.1
#=GS A0A024WR58_PLAFA/10-80 AC A0A024WR58.1
#=GS A0A0L7M8Y9_PLAF4/2-132 AC A0A0L7M8Y9.1
#=GS A0A1A8WKF7_PLAMA/2-144 AC A0A1A8WKF7.1
#=GS A0A509B269_PLABA/80-296 AC A0A509B269.1
#=GS A0A1Y1JLQ1_PLAGO/1-106 AC A0A1Y1JLQ1.1
#=GS K6V7K9_PLACD/17-157 AC K6V7K9.1
#=GS W7JDS7_PLAFA/2-132 AC W7JDS7.1
#=GS A0A1J1H574_PLARL/1-104 AC A0A1J1H574.1
#=GS A5K4M8_PLAVS/1-106 AC A5K4M8.1
#=GS W4IQV5_PLAFP/9-81 AC W4IQV5.1
#=GS Q7RET0_PLAYO/2-151 AC Q7RET0.1
#=GS A0A509AME9_PLABA/2-151 AC A0A509AME9.1
#=GS A0A0L7KLK4_PLAFX/2-132 AC A0A0L7KLK4.1
#=GS Q8IBD0_PLAF7/2-132 AC Q8IBD0.1
#=GS A0A653H226_9APIC/2-138 AC A0A653H226.1
#=GS Q7RQT8_PLAYO/2-126 AC Q7RQT8.1
A0A1A8XGC4_9APIC/1-105 ............m--KLVSAIFL.-FFLIF.LVENTLGDN..II-GGGNSGPK..KKVQK............--------------............................................................................................-RSPEPLID..V..HELIGDMVKKEEELVKLSKKKSTYKTATTILATALGVVSALLLGGTGLVLYNTERGRH..............
A0A0L1IAR5_PLAFA/2-132 .............KNKLSTLFFItIFLILI.FIDSAKGDE..RKNFWKSRFTAgrGNITN............KPTEVNHPIKKEGEnfl......................................................................................svgKGDHDES--..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn........
A0A1D3JCN4_9APIC/2-151 .............KNKLSSLFVI.SFFLLVvFSNVIKGDN..NINKKRDMWIS..RFFLG...........kRDQKTDNDVSEEEHkakiekakie.......................................................................kekkekeeiltSNNKEDMND..VrsMLLLKEIYEKDNQLSIISRKKKKYKTATFTLGTLLTLIAVRALANLAVNGL-------tklvqkeen.....
A0A1A8WRG8_9APIC/2-151 .............KNKLSSLFVI.SFFLLVvFSNVIKGDN..NINKKRDMWIS..RFFLG...........kRDQKTDNDVSEEEHkakiekakie.......................................................................kekkekeeiltSNNKEDMND..VrsMLLLKEIYEKDNQLSIISRKKKKYKTATFTLGTLLTLIAVRALANLAVNGL-------tklvqkeen.....
A0A1D3THZ1_9APIC/1-105 ............m--KLVSAIFL.-FFLIF.LVENTLGDN..II-GGGNSGPK..KKVQK............--------------............................................................................................-RSPEPLID..V..HELIGDMVKKEEELVKLSKKKSTYKTATTILATALGVVSALLLGGTGLVLYNTERGRH..............
Q7RLY3_PLAYO/2-123 .............NTKLYSLFVF.ICLIIV.YCATVQGSK..-DNGKNGVYEL..KMIKKk.........hkKNNKDNKHVQRAGE............................................................................................DEDEDDNID..Y..TNLVKEEEKRNEEVKRLSKMHKAY---TLGMSTIIFLSTLFLIRDCVLESISRPDSY-i.............
A0A509AQ14_PLABA/2-104 .............KINIASILFI.-IFSLC.LVNNAYGKN..K----HGKTGS..KNVIK............--------------............................................................................................-KPAEPVID..V..QELISDMVKKEEEIVKLAKNKKSLRKANVALATALSVVSALLLGGAGLVMYNTEKGRH..............
A0A0L0CW34_PLAFA/2-132 .............KNKLSTLFFItIFLILI.FIDSAKGDE..RKNFWKSRFTAgrGNITN............KPTEVNHPIKKEGEnfl......................................................................................svgKGDHDES--..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn........
K6UDF1_PLACD/1-106 ............m--KLLTAVFL.-LFCAI.LCDPALGDN..VN-GLGGPPSK..KKTPK............--------------............................................................................................SKSPEPLID..V..HELIGEMVRKEEELINANKKKSKYKLATTILASALGVVSAVLLGGAGLVFYNAGNGRH..............
W4IU23_PLAFP/1-108 ............m--KILSVFFL.ALFFII.FNKESLAEK..TNKGTGSGVSS..KKKNK............--------------............................................................................................KGSGEPLID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH..............
A0A024X986_PLAFC/2-132 .............KNKLSTLFFItIFLILI.FIDSAKGDE..RKNFWKSRFTAgrGNITN............KPTEVNHPIKKEGEnfl......................................................................................svgKGDHDES--..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn........
Q7RI01_PLAYO/2-151 .............NTKLYSLFFF.IYLIIV.YCATVQGNK..NSNGKADGHGL..SFIKKv.........yqNSNNKDKHMLRTDEdgigtfnikylykcvyytyiqiiqncssy.................................fillheivlciinnfcfinpsgdvvidilkKEYVDPHI-..-..IKLVDIVNKKE-----------------------------------------------iinffnvlknrpyv
A0A384LP13_PLAKH/1-106 ............m--KLLTAVFL.-LFCAI.LCDHAFGNN..IN-HSGPHHPK..KKTPK............--------------............................................................................................SKAPEPLID..V..HELIGEMVRKEEELINVTKKKSKYKLATTVLASALGLVSAVLLGGAGLVFYNAGNGRH..............
A0A024W4Z2_PLAFA/1-108 ............m--KILSVFFL.ALFFII.FNKESLAEK..TNKGTGSGVSS..KKKNK............--------------............................................................................................KGSGEPLID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH..............
A0A0L7KLW0_PLAFX/1-108 ............m--KILSVFFL.ALFFII.FNKESLAEK..TNKGTGSGVSS..KKKNK............--------------............................................................................................KGSGEPLID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH..............
A0A1A8YK68_9APIC/2-154 .............KNRLSSLFVI.SFFLLVvFSNVIKGDN..NINKKKDMWIS..RFFLG...........kRDQKTDNDVSEEEHkakiekakiekek..................................................................iekekkekeeiltSNNKEDVND..VrsMLLLKEIYEKDNQLSIISRKKKKYKTATFTLGTLLTLIAVRALANLAVNGL-------tklvqre.......
A0A024WQD4_PLAFA/1-108 ............m--KILSVFFL.ALFFII.FNKESLAEK..TNKGTGSGVSS..KKKNK............--------------............................................................................................KGSGEPLID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH..............
W7JTD3_PLAFO/1-108 ............m--KILSVFFL.ALFFII.FNKESLAEK..TNKGTGSGVSS..KKKNK............--------------............................................................................................KGSGEPLID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH..............
A0A024VS38_PLAFA/454-583 .............KNKLSTLFFItIFLILI.FIDSAKGDE..RKNFWKSRFTAgrGNITN............KPTEVNHPIKKEGEnfl......................................................................................svgKGDHDES--..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqks.........
Q7R7H8_PLAYO/2-130 .............NKKLYSLFFL.IYLIVL.YCATVQGNK..DDNGKNDRHGK..NIIKK............NYNKNNKQMKGTNEdhte...................................................................................dneefDENYEDNKE..S..MRLINKKEKKESEANKLSKIKKAY---AFGITTVIALNILFLLKNYINNNLADPNGHI..............
W7K608_PLAFO/9-81 .nflsvgkgdhde----------.------.---------..-----------..-----............--------------............................................................................................--------S..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTRL----nqksn.........
A0A1A8YUQ5_9APIC/1-105 ............m--KLVSAFFL.-FFLIF.LVENTLGDN..II-GGGNSVPK..KKVQK............--------------............................................................................................-RAPEPLID..V..HELIGDMVKKEEELVKLSKKKSTYKTATTILATALGVVSALLLGGTGLVLYNTERGRH..............
A0A1C3KCK0_PLAMA/26-106 agsttpppkkksp----------.------.---------..-----------..-----............--------------............................................................................................KKTPDPLID..V..HEIINDMVKKEEEIVNLSKKKSAYKTATTALASTLGLVSALLLGGIGLVLYNNERGRH..............
W7JLS6_PLAFA/1-108 ............m--KILSVFFL.ALFFII.FNKESLAEK..TNKGTGSGVSS..KKKNK............--------------............................................................................................KGSGEPLID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH..............
Q7RGC6_PLAYO/2-107 .............KINIASIIFI.-IFSLC.LVNDAYGKN..KY-GKNGKYGS..QNVIK............--------------............................................................................................-KHGEPVIN..V..QDLISDMVRKEEEIVKLTKNKKSLRKINVALATALSVVSAILLGGAGLVMYNTEKGR-r.............
A0A679L6W5_PLAKH/2-148 .............KHKLPILLVI.NLFLLItFGDVIKGDN..ITNKKKDIWKS..RFTAGk..........gTPKKNENSIDKNKEkdkgkdkdikk......................................................................nkddfltslinKEDMNDSRN..-..IMLLREIYEKDNELSIIRRKKKKYKTATFTLGTLITIIALRAIADLAVKGI-------sklfeqe.......
A0A0L7M439_PLAF4/1-52 ............m----------.------.---------..-----------..-----............--------------............................................................................................---------..-..-------IKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH..............
A0A2N0Z4M0_9BACI/21-110 ........ktnli---LNSLIVI.VILLIVfVSYTIFGSK..DE-ANGDKTVK..EKTAE............-TKKDNNTTETVNG............................................................................................NTDESTNSD..E..EKTLEEDESKTEEEAIV-----------------------------------------teggsds.......
A0A024W8Z7_PLAFA/2-132 .............KNKLSTLFFItIFLILI.FIDSAKGDE..RKNFWKSRFTAgrGNITN............KPTEVNHPIKKEGEnfl......................................................................................svgKGDHDES--..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn........
A0A1Y1JD46_PLAGO/2-142 .............KSKLSILFVI.NLLLLItVSDVIKGDN..SINKNKDIWKS..RFTVGkgtpkknediseK---N--------Kkkdnkke..............................................................................kddiqtgINNRDDMNDsrS..IMLLREIYEKDNQLSIVNRKKKKYKTATFTLGTLLTIIALRTIADIAVKGI-------sklfqke.......
Q8IIF0_PLAF7/1-108 ............m--KILSVFFL.ALFFII.FNKESLAEK..TNKGTGSGVSS..KKKNK............--------------............................................................................................KGSGEPLID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH..............
A0A024X652_PLAFC/1-108 ............m--KILSVFFL.ALFFII.FNKESLAEK..TNKGTGSGVSS..KKKNK............--------------............................................................................................KGSGEPLID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH..............
A5K5F2_PLAVS/2-143 ............r-HKLPILLVI.NLFLLItFGDVVKGDN..IINKKKDIWKY..RFTVGkgtp....kkneDFNDKNK------Dkdkdnkk.............................................................................dkddfltsGNHKDDMND..SrsIMLLREIYEKDNQLSIINRKKKKYKTATFTLGTLITIIALRAIADLAVKGI-------sklfqk........
A0A024WR58_PLAFA/10-80 ...lsvgkgdhde----------.------.---------..-----------..-----............--------------............................................................................................--------S..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTRL----nqksn.........
A0A0L7M8Y9_PLAF4/2-132 .............KNKLSTLFFItIFLILI.FIDSAKGDE..RKNFWKSRFTAgrGNITN............KPTEVNHPIKKEGEnfl......................................................................................svgKGDHDES--..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn........
A0A1A8WKF7_PLAMA/2-144 ...........ky--KVSVLYVI.TVFLLIaFSDVIKGDNsnNDNKKKDMWKS..RFSLGkgtq...ktdgdANEKNDKNHDKEKKekefl.................................................................................mnnlkgADMNDPRS-..-..VMLLKEIYDKDNQLSIISRKKKKYKTATFTLGTLLTIIAIRTLTEFAVKSIA------kffqk.........
A0A509B269_PLABA/80-296 .............NTKLYSLFVF.IYLIIV.YCATVHGNK..NDNGKNNGNGL..SFIKKiy........qnDNNKDNKHVQRTGEdgigtfdikylykcfcyvyiqviqncvntkvciqckclhniiylfhsplilfyymkvfkwfliyflliiilciinnfcfinpsgdvivdilkKEYVDPHI-..-..IKLVDIVNKKENKLKKINERKHIYQLLAMSLGALFISRLIYDIKGQYMSSIENPNS--mi............
A0A1Y1JLQ1_PLAGO/1-106 .........mkpi-----TAVFL.-LFCLI.LCDNAYGDN..INGGGNTNIPK..KKTPK............--------------............................................................................................-KAPEPLID..V..HELISEMVRKEEELVTVTKQKSKYKMVATVLASLLGIVSGVLAGGAGLVLHNTSKGR-p.............
K6V7K9_PLACD/17-157 ............r-HKLPILLVI.NLFLLItFGDVVKGDN..IINKKKDIWKS..RFTVGkgtp....kkneD--FNDKNKDKDNKkdkd...................................................................................dfltsGNNKDDMNDarS..IMLLREIYEKDNQLSIINRKKKKYKTATFTLGTLITIIALRALADLAVNGIA------kifkke........
W7JDS7_PLAFA/2-132 .............KNKLSTLFFItIFLILI.FIDSAKGDE..RKNFWKSRFTAgrGNITN............KPTEVNHPIKKEGEnfl......................................................................................svgKGDHDES--..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn........
A0A1J1H574_PLARL/1-104 ............m--NLSSIIFL.TFFFIL.FNKSIEGKV..TS-VE----NN..KTIPK............-----------KKS............................................................................................K--QKLDID..V..SEILSDMIKKDEELVKVSKSRSKYKVITGALASTLAILAAAVASGVGLVLYNTSHNRH..............
A5K4M8_PLAVS/1-106 ............m--KLLAAVFL.-LFCAI.LCNHALGDN..VN-GLGAGNPK..KKSPK............--------------............................................................................................SKSPEPLID..V..HELISEIVRKEEELVNMTKKKSNYKLATTVLASALGVVSAVLLGGAGLVFYNAGNGRH..............
W4IQV5_PLAFP/9-81 .nflsvgkgdhde----------.------.---------..-----------..-----............--------------............................................................................................--------S..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTRL----nqksn.........
Q7RET0_PLAYO/2-151 .............KQKLHTFFVI.ICLVVVlYCGGIDGKQ..NNNIKRDMWMS..RFFNHk.........ngKYMKNEKKVEKSEGanknneilddih...................................................................sddideivknvlkSENVDNQT-..-..LKIIKELDKKKNEIIIANKKKNLYKSSAFSMGVIFVGLALRELTALLVGLYLDKHPNT..............
A0A509AME9_PLABA/2-151 .............KHKLHTFFVI.ICLVVVlYCGGIEGKQ..NNNIKKDMWIS..RFFTHk.........ngKYARNEKTVENAEGgnknneilddly...................................................................nedidevvknilkSENVDIQT-..-..LKIIKELDKKKNEVIIANKQKNLYKSGAFGMSVIFLSFALRELAELLVNYYLDKHHNT..............
A0A0L7KLK4_PLAFX/2-132 .............KNKLSTLFFItIFLILI.FIDSAKGDE..RKNFWKSRFTAgrGNITN............KPTEVNHPIKKEGEnfl......................................................................................svgKGDHDES--..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn........
Q8IBD0_PLAF7/2-132 .............KNKLSTLFFItIFLILI.FIDSAKGDE..RKNFWKSRFTAgrGNITN............KPTEVNHPIKKEGEnfl......................................................................................svgKGDHDES--..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn........
A0A653H226_9APIC/2-138 ............a-NKLLSLFVI.TIFFLVnFSYVITGHK..NENSKNNMWIS..RFNMG...........kDGNKINKDADRHLHetykkd................................................................................tdnllnSNKKDVFTDerS..ALLLKEIYTKDKELSIIKRKKKMYKNATITLGTLIAVIAIRLIKKYIENYLL------klvd..........
Q7RQT8_PLAYO/2-126 .............NTKLYSLFVF.IYLIVV.YCATVQGNK..--NGKNDVHEP..NGINK...........kSNKKDNKHVQKTDGied.....................................................................................yenfDKNCEPNKE..S..MNSVKEED-IESEAIRASKKKEAY---IVGISSLATVLTLSMLRGCALAVVVNSNS--yn............
#=GC seq_cons ...............KL.olFhl..hhhll.asssshG-p..ppptttshhss..chhsp......................................................................................................................ptst-s..s..h..h.LlpEhhcK-pELshlsKKKpKYK.hTssLAollulluhhhlGulslshhsp...................
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