#=GF ID CSS_CxxC
#=GF AC PF20982.1
#=GF DE CSS_CxxC domain
#=GF AU Galperin MY;0000-0002-2265-5572
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE Galperin M
#=GF GA 27.30 27.30;
#=GF TC 27.30 27.60;
#=GF NC 26.70 27.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 35311563
#=GF RT Comparative Genomics of Cyclic di-GMP Metabolism and
#=GF RT Chemosensory Pathways in Shewanella algae Strains: Novel
#=GF RT Bacterial Sensory Domains and Functional Insights into Lifestyle
#=GF RT Regulation.
#=GF RA Martin-Rodriguez AJ, Higdon SM, Thorell K, Tellgren-Roth C,
#=GF RA Sjoling A, Galperin MY, Krell T, Romling U;
#=GF RL mSystems. 2022; [Epub ahead of print]
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is a periplasmic sensor domain found at the N-terminal of
#=GF CC c-di-GMP phosphodiesterases, which is a variation of the CSS
#=GF CC motif sensor Pfam:PF12792 [1]. This domain, apart of the CSS
#=GF CC motif, has an additional conserved CxxC motif, which presumably
#=GF CC broaden its redox-sensing palette. It has been found in
#=GF CC Shewanella spp. and other members of Altermonadales, Vibrionales
#=GF CC and in some acidobacteria [1].
#=GF SQ 33
#=GS A0A1Y6L0J9_9GAMM/47-175 AC A0A1Y6L0J9.1
#=GS U1JNK6_9GAMM/39-166 AC U1JNK6.1
#=GS A0A545UIW8_9GAMM/40-175 AC A0A545UIW8.1
#=GS A0A1Y6L062_9GAMM/58-188 AC A0A1Y6L062.1
#=GS A0A6G8D6F7_9VIBR/33-170 AC A0A6G8D6F7.1
#=GS B1KEW5_SHEWM/50-181 AC B1KEW5.1
#=GS A0A6G9QNW0_9GAMM/36-167 AC A0A6G9QNW0.1
#=GS A0A4R6NAY5_9BURK/46-175 AC A0A4R6NAY5.1
#=GS A0A0Q0GL21_9GAMM/36-166 AC A0A0Q0GL21.1
#=GS A0A545UJF2_9GAMM/34-162 AC A0A545UJF2.1
#=GS A0A0D8D6Y7_9GAMM/38-173 AC A0A0D8D6Y7.1
#=GS R8AQ44_PLESH/14-149 AC R8AQ44.1
#=GS Q6LT27_PHOPR/65-193 AC Q6LT27.1
#=GS R8APE4_PLESH/27-164 AC R8APE4.1
#=GS A0A839IU20_9GAMM/44-169 AC A0A839IU20.1
#=GS Q9KN64_VIBCH/38-175 AC Q9KN64.1
#=GS Q6LJ31_PHOPR/57-188 AC Q6LJ31.1
#=GS A0A0J1GR09_9GAMM/28-159 AC A0A0J1GR09.1
#=GS C9P839_VIBME/1-115 AC C9P839.1
#=GS A0KF89_AERHH/1-117 AC A0KF89.1
#=GS A0A1S2U0B8_9GAMM/39-170 AC A0A1S2U0B8.1
#=GS Q1IP01_KORVE/42-170 AC Q1IP01.1
#=GS A0A0Q2V4W8_VIBFU/33-169 AC A0A0Q2V4W8.1
#=GS A0A178K8C3_9GAMM/39-170 AC A0A178K8C3.1
#=GS Q8E9W7_SHEON/36-166 AC Q8E9W7.1
#=GS A0A3E0U191_9GAMM/39-166 AC A0A3E0U191.1
#=GS A0A0A5I3U3_PHOS4/45-170 AC A0A0A5I3U3.1
#=GS D0I6J3_GRIHO/37-168 AC D0I6J3.1
#=GS A0A2V4NBC9_VIBCL/38-175 AC A0A2V4NBC9.1
#=GS A0A0J1H9M8_9GAMM/38-169 AC A0A0J1H9M8.1
#=GS A0A2T3MZV2_9GAMM/46-177 AC A0A2T3MZV2.1
#=GS A0A1I1LZ01_9GAMM/37-172 AC A0A1I1LZ01.1
#=GS Q87NV0_VIBPA/39-169 AC Q87NV0.1
A0A1Y6L0J9_9GAMM/47-175 ......................ehqr-----SENYLHSIQSTSILLDNLQYH........LSYTCDKEDISELERASYYSSHIRSISLETKSGK.VCGDHSNLS.QLYGS.....--PAKKI.PL.NREVVVIANADNNES.IVQYRKQVVGGVITVDIAQQPTNALLSNACDQC-w.............
U1JNK6_9GAMM/39-166 .........................e-LEFLLEKLETHVGEAINMNEQFTQT........LAFDCSASDMTQMQRAAFTSPHVRLFEVHIENGK.ECSSHGKAI.EQSEE.....-ASWHAL.RD.NVFIGSELNSITHTH.DLAVIYKTPNYRLIADIEPI---HIPRAFCDECA..............
A0A545UIW8_9GAMM/40-175 ..........................DAEKLLYQFHDALTKAREVLDSLPAP........LSFSCNRQSIKQLAKLAFEHPSIRLIGVKHGDQE.ACASEPIDV.DLSHYhdrivSAENHQL.AD.NLALATKENANGRL-.DLLMIRSHADSRYFASINPFMIDYLTEFACRNCL..............
A0A1Y6L062_9GAMM/58-188 .........................s--SDLIDNYTTTIGDYQSFIKPIVKN........IRFDCGSHDKNYIEKITYNNYYIRNIDIETNNNK.HCSSFVNKA.EFNST.....SVFIKKL.DK.NLSLWTTVNSVNKQS.ILSLVWKGKLGQIVIRFEPIISDVIRNKYCDNCI..............
A0A6G8D6F7_9VIBR/33-170 .......................aql----LLNQKFAEINQSIEQRNLALDTmvatqvqsLTFSCNSNDMQLIRDPQFYNRFIRLIGIETAQGV.SCSTIGYPI.PLPTE.....-LSSSEM.AM.GYHLSATPTSQTASR.ELLIQYIEPRGRVFWVVDGSWAQELLLKPCSDCF..............
B1KEW5_SHEWM/50-181 .............dldflaqslikqt-----------TILATDEGKES-FSQ........LSWSCNEADIALLKSAEFSPEMVRLVQMELASGE.KCSNLSSPYyHMAQN.....TKKYPQS.NI.EVSISADQNPFLRD-.-FIFEFPVGNHSLIAITNRTVFNSFLTDLCPNC-y.............
A0A6G9QNW0_9GAMM/36-167 ..........................DAAMLTDKFERLIKTSAAQLNALPDIt......fDSFECNDEVEAQLKRTVFDASFIRWVGVAKGLNI.YCESNEVIR.EVHKV.....--KHHQI.SE.TYSLGVLESITGQHL.ELILIRNMGDIFYVASLIPLEPRYFVPMSCEHCL..............
A0A4R6NAY5_9BURK/46-175 .........................q-GEALLHEFQASLRQAGQELLALDPA........EARACEGGLSLSLARRTFSNAGVRWMAIAREGEL.LCRSHVVGV.PWNGA.....-KRVHKV.DA.QWSLIALEPGEGRY-.GLFLSREQQGLQYLAALEPPNLDAVGEASCAQC-r.............
A0A0Q0GL21_9GAMM/36-166 ..........................DAQILSEKLTMYIEDTAIELKSLPAI.......nDTYVCDSQNEDLLTKSVFNSTFIRWLAVMDQLKV.ICRSQIIPR.HVEKL.....--VRHRI.GP.DVKLAVLNQPDSDVH.ELFLSYESGKKQYVASIVPMNPRYFIPVNCEDCL..............
A0A545UJF2_9GAMM/34-162 ..........................DGEKIAQRMENVIVDSIRVIDSLPAL........TEVKCSQQSIQLLANVVYEADSVRWLGLSDQNGD.YCSSLPLDI.SLNKF.....--QKHKL.YG.DYSLATLDQSDGHS-.ELLLIKESAESLYVADLNNLSVNTLNDLPCESCV..............
A0A0D8D6Y7_9GAMM/38-173 ..........................DAEQLLYQFHDAILEADKILAGLPDP........ELFQCSQKDIEQLAMLAFEHPAVRLIGVLHGDQQ.ACASEEVHI.DLSDYhervlGPIKHQL.TD.THALATVSHGDEHL-.DLLMVRSHDNSRYFASINPFMVNYLTEFVCMNCL..............
R8AQ44_PLESH/14-149 ........klegfyyaanersdairh------------------VMKNEITN........IQFDCGKHDVQILRDLNLYNSQFRVQGIELKDGG.GCSSLGSDL.SILSPse.pkTYAYKFY.GY.DVGFTTTHDITNTGG.EVVTFINVNGNFIYWVLNSAWTHEQLQSPCKNCF..............
Q6LT27_PHOPR/65-193 ......................enqr-----IEQYFERVRATSILLDNLQYE........LNYTCDNQDIDTLEHASYFNAEIRRLSLRTPNGI.TCGDMVDTL.NIYAK.....PKQEIYL.NQ.QISLIANTSKDRTI-.-IQYHRQILKGFITVDITPQDPISLLKNECDGC-w.............
R8APE4_PLESH/27-164 .iwkmdnleimalkrdqlikhtmiqd-------------------------Ia......dLKFDCGKDDIETLRNLNLYNSQFRVQGIKLANGS.GCSSLGPDL.DIISRa..rmQQSMYKL.DNyNIGITSTAQSYGVHG.EQVIFANINGNYVYWVLNGAWTYEQLQTPCKDCF..............
A0A839IU20_9GAMM/44-169 .....................dgqrg-----LQRLEHFIDQTRETLQQITQQ.......hEYINCSAQTITELRQHVFLSSRLKEVGLMDQNHRiYCVSNAGPV.NFKLYp..etRKRLADS.TN.DMTLSLTKAKMSQSR.SLFIYYQAKDG-----------------------mgadallrpqtf..
Q9KN64_VIBCH/38-175 .........................v-AQHLLNQKFAEINQYLEQRNLALDSmithqvqsLTFTCNNHDLQLIRDPQFYNRFVRLIGIENAQGD.GCSTIGYPI.ALAED.....--SSAAE.PT.GFTLSATPKTQTASR.ELLIQYSEPRGRVFWVVDGSWAQDLLREPCGDCF..............
Q6LJ31_PHOPR/57-188 ..........................DSKDLLNTYMLRIDNYHPIMKGISDN........FQFNCKALDETKIQQVAYNDYFIRRITLTTNDGE.QCTSFKGAS.AESKL.....LPLIDQL.ST.NLSLWVTSELGDQEN.LLVVEWKDKRGSMLVHMEPLISDILKNKYCDNCV..............
A0A0J1GR09_9GAMM/28-159 ..........................DSRRLLKHYADQINDYPAMMNALREQ........LLFDCSAYDKHQLKHITYNDYQIRRMTLSLPDGT.TCTSFDGAN.NQDNR.....VPLISHL.TD.DISLWVATEPRFSQQ.IMVVEQQTDKGGLNVYMEPLATEGLRNKYCGDCV..............
C9P839_VIBME/1-115 ......................miqq----------------------QIKQ........LQFDCGDHDWQVIRDPHYYSRYIRFMGIATNEGK.QCSTLGYPL.EWTAL.....SDLNHSKgAA.VFSLAATPDIAGTES.ELMIQFSQEGNTAIWVLDSSWTQSKLNQPCSGCF..............
A0KF89_AERHH/1-117 .....................mdesi--------------------RAQLAQ........FTFDCGQKDMALLRDPRFYSRHIRIQGLKLASGT.GCSSLGVDL.PFTAA.....DLPPYPS.QE.LFGLAATQARFNTEQ.ELVAYFHVGNNTAYWVLNNSWSHALLQYPCTDCF..............
A0A1S2U0B8_9GAMM/39-170 ........kqfklmeeylsqrqrsin-----------------DIILHQVPE........FHFDCGPKDAKLLRSPENYNRYFRVMGIKTKTGL.GCSSLGTDL.LLPDL.....-PNDTYV.GQ.GFGLTTTGAMYDTEQ.ELLVYFKSNGNTAYWILDSSWIRELINVPCSDCF..............
Q1IP01_KORVE/42-170 ..........................QAAMMLRGFQDGYQNARADLAKLPSM........EEMNCRDGISDTLARLNFDNQYVRWYGIAQEGKV.ICRGPRVGV.DLSDA.....--RFHRI.DD.EWFLISTESPTKAS-.NLLLAQKRGNLLYLAMLEPLLFDFMHEVDCKACV..............
A0A0Q2V4W8_VIBFU/33-169 lfllnhkmdevsrylaergrvlnhmm--------------------IEQADQ........LQFDCSEDDMHLMRAPKYYNHYVRLIGVITANGK.SCSTVGVSL.VADEL.....-EGVRIP.AT.GFYMATTPAYEHSES.ELLVMYKKGGNLIYWVLYGGWGRELLKTPCDDCF..............
A0A178K8C3_9GAMM/39-170 ..........................DAEAMLGIYSKQIETYERKLAEFSNL........FLYDCGPLDQYQLENLAYKDYFIRRLSLKTRTGK.TCTSFAGAN.GERTL.....SPLLPFL.TP.NTSLWVTNSAGNDQS.LLVVQREDERGALFVHMEPLITDSLRNNYCRECV..............
Q8E9W7_SHEON/36-166 ..........................DSEMLASKFQMYITESAEQILEMPRL.......dPGVTCTAELESLLKQKTFDSSFVRWLAIYKDNQV.LCQSGVIPH.DLTAL.....--KAHKV.RE.NLSIAVASHNTQTSH.ELFLMRHMEGIDYIASITPLRPRYFVPVDCERCL..............
A0A3E0U191_9GAMM/39-166 .........................e-LEYLIGKLDSHVTEAIRLNDEFTEE........LAFDCSISDIEKMQRVAFTSPHVRLFEVHIAGGK.ECSSHGLAV.EQDEK.....-ASWKNL.RD.NIFIGSELNKINHTH.DLTVIYQGEGFNLIADIEPI---HIPKAFCENCA..............
A0A0A5I3U3_PHOS4/45-170 .....................dgsds-----INKLERYIDTMADDLQTLAIK........VGDDCSEQDKLALRAKVFNSRMLKEIGLYKDGIV.YCTSNEGPS.QIRLFn..stLQRIDAS.PK.HITISLTESKSKLK-.TFFIYSSSDKKR----------------------ginallhpqqflel
D0I6J3_GRIHO/37-168 .....................eskaq---ELNEYVEARSDHINNVIMQQLLK........FNYDCSEADIQTLHNPLFYNHYVRFVGMYTADGK.SCSTLGDFI.GIKEL.....---QHDE.ST.HFPIGFRVGLTSNEHaEFFIQYSLNGHHLYWVLDNSWVSEKINARCKDC-y.............
A0A2V4NBC9_VIBCL/38-175 .........................v-AQHLLNQKFAEINQYLEQRNLALDSmithqvqsLTFTCNNHDLQLIRDPQFYNRFVRLIGIENAQGD.GCSTIGYPI.ALAED.....--SSAAE.PT.GFTLSATPKTQTASR.ELLIQYSEPRGRVFWVVDGSWAQDLLREPCGDCF..............
A0A0J1H9M8_9GAMM/38-169 ..........................DVEQTLSYYSSQITHYPEKLSQLASV........FEFNCLEQDRRQLQQLTYHDYLIRRMRLQLPDGR.HCNSMESIE.PERQL.....LPLVSPL.RE.GVGLWVANEAHSNEQ.LLVVEKHVEIGKLLVYLEPLISDSLRDKYCTSCL..............
A0A2T3MZV2_9GAMM/46-177 ..........................DSKELLQTYSMNISELQTVLSKLSEK........FQFDCGALDEYQMQHVAYNDYIIRRITLQTRDGK.QCTSFKGAG.TETRL.....APLIKNL.SA.NVSLWVTSESRTEQN.ILVTEWKDERGTMLVHMEPLVSDTLRNKYCDDCI..............
A0A1I1LZ01_9GAMM/37-172 ..........................DAEQLLFQFHDSVVEAHKMLDSLPEP........ENFQCDNKNIEKLAMLEFEHPNVRLVGVFHDNKQ.ACASQDVHI.DIRNYhervlNPSKHQL.SN.NYSLATVSHGDKHI-.DLLLVKSHADSKYFASINPFMVNYLTEFACTNCL..............
Q87NV0_VIBPA/39-169 ........................ki--ETLVKYLNQRSTFLESAITKQIAQ........LDFNCQSDDMKVLRDPRYYNRYIRFIGMTTEDGD.SCSSVGMPV.SKVTS.....-SERVQL.DT.NFYISLILPEYKDQA.EWMVIYDNQHVEVFWVLDNSWVKQLIAEPCEECL..............
#=GC seq_cons ............................t.hlpphtttlpph.phlpphspp........hpFsCsspDhphLcphsa.sphlRhlulppssGp.tCoShsssl.shsph.......thcpl.ss.shuLussssspsppp.-LllhhppspsphhhslpshhsptlhptsCpsCh..............
//
