#=GF ID   CTD11
#=GF AC   PF20277.2
#=GF DE   C-terminal domain 11 of the ABC-three component (ABC-3C) systems
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Aravind L
#=GF GA   27.70 27.70;
#=GF TC   27.90 28.20;
#=GF NC   27.00 27.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   32894288
#=GF RT   Comprehensive classification of ABC ATPases and their functional
#=GF RT   radiation in nucleoprotein dynamics and biological conflict
#=GF RT   systems.
#=GF RA   Krishnan A, Burroughs AM, Iyer LM, Aravind L;
#=GF RL   Nucleic Acids Res. 2020;48:10045-10075.
#=GF DR   INTERPRO; IPR046921;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   C-terminal domains (CTDs) of ABC-3C systems, contain distinct
#=GF CC   patterns of charged and polar residues and are not yet unifiable
#=GF CC   with known domains. These domains are found at the C-terminus of
#=GF CC   the effector component of the systems, which are upstream of the
#=GF CC   Middle Component and ABC ATPase components on the genome. Due to
#=GF CC   the typically large size of these CTDs relative to the actual
#=GF CC   effector and MC domains, the CTDs are predicted to serve as the
#=GF CC   platform on which the remaining two components assemble.
#=GF CC   Therewith, conformational changes transmitted by the ABC
#=GF CC   ATPase-mediated detection of invasive elements like DNA viruses
#=GF CC   would result in an unfurling and activation of the
#=GF CC   CTD-associated effector [1].
#=GF SQ   87
#=GS A0A5E4X1Z7_9BURK/123-261  AC A0A5E4X1Z7.1
#=GS V7I5Q9_9CLOT/252-392      AC V7I5Q9.1
#=GS A0A4V6NGB1_9FIRM/126-263  AC A0A4V6NGB1.1
#=GS A0A1C0BXL2_9FIRM/235-372  AC A0A1C0BXL2.1
#=GS K1LUB0_9LACT/240-380      AC K1LUB0.1
#=GS A0A6A0B7F7_9LACT/253-388  AC A0A6A0B7F7.1
#=GS A0A371IQ39_9FIRM/115-253  AC A0A371IQ39.1
#=GS A0A1I1X747_9FIRM/261-351  AC A0A1I1X747.1
#=GS A0A1I7L772_9BURK/83-221   AC A0A1I7L772.1
#=GS A0A4D6B553_9CAUD/237-373  AC A0A4D6B553.1
#=GS A0A371ILA6_9FIRM/1-92     AC A0A371ILA6.1
#=GS A0A0R2KH19_9LACO/237-370  AC A0A0R2KH19.1
#=GS A0A7H0SRI2_9CORY/269-407  AC A0A7H0SRI2.1
#=GS F8DZX3_CORRG/269-408      AC F8DZX3.1
#=GS A0A8J2ZXD4_9BACL/272-407  AC A0A8J2ZXD4.1
#=GS E7MNK2_9FIRM/113-252      AC E7MNK2.1
#=GS A0A6P1IYE8_9BURK/114-254  AC A0A6P1IYE8.1
#=GS W4TFX4_CUTAC/17-140       AC W4TFX4.1
#=GS D9QBJ5_CORP2/234-368      AC D9QBJ5.1
#=GS A0A1U7MJI1_9FIRM/117-256  AC A0A1U7MJI1.1
#=GS A0A0F4KR17_9LACO/263-403  AC A0A0F4KR17.1
#=GS A0A0R2FTM8_9LACO/282-420  AC A0A0R2FTM8.1
#=GS A0A412AXM5_9FIRM/260-396  AC A0A412AXM5.1
#=GS A0A1I4QPU9_9BACL/117-256  AC A0A1I4QPU9.1
#=GS A0A4Q0T8C2_9BACT/50-190   AC A0A4Q0T8C2.1
#=GS A0A0L6Z9C9_9CLOT/272-407  AC A0A0L6Z9C9.1
#=GS A0A2V2NB83_9EURY/123-263  AC A0A2V2NB83.1
#=GS D0Z2M1_PHODD/116-256      AC D0Z2M1.1
#=GS A0A1H3ZXE1_9FIRM/236-373  AC A0A1H3ZXE1.1
#=GS A0A1H0JAT3_9PSED/114-254  AC A0A1H0JAT3.1
#=GS A0A369BH46_9BACL/113-250  AC A0A369BH46.1
#=GS A0A140L450_9CLOT/272-407  AC A0A140L450.1
#=GS A0A1I7JU69_9FIRM/210-347  AC A0A1I7JU69.1
#=GS I0HWB8_RUBGI/113-253      AC I0HWB8.1
#=GS A0A3E2N9J4_9CLOT/328-471  AC A0A3E2N9J4.1
#=GS A0A7T3V5D3_9SPIR/142-292  AC A0A7T3V5D3.1
#=GS B9YD47_9FIRM/279-415      AC B9YD47.1
#=GS D6ZG28_MOBCV/246-383      AC D6ZG28.1
#=GS A0A448PFZ5_9ACTO/244-385  AC A0A448PFZ5.1
#=GS G5KI97_9STRE/237-373      AC G5KI97.1
#=GS Q9A0Y9_STRP1/227-363      AC Q9A0Y9.1
#=GS A0A5C4SR66_9FLAO/154-174  AC A0A5C4SR66.1
#=GS R5EH97_9FIRM/128-265      AC R5EH97.1
#=GS A0A0A2T6S8_9BACI/112-252  AC A0A0A2T6S8.1
#=GS A0A6C1B994_9RHOO/114-254  AC A0A6C1B994.1
#=GS R5CJN2_9FIRM/101-245      AC R5CJN2.1
#=GS A0A3A9HZ41_9FIRM/222-362  AC A0A3A9HZ41.1
#=GS A0A7Y8KY76_9BURK/114-254  AC A0A7Y8KY76.1
#=GS A0A433HAV6_9BACI/112-251  AC A0A433HAV6.1
#=GS A0A1I3SA24_9BACL/113-252  AC A0A1I3SA24.1
#=GS A0A1M6KY46_9FIRM/235-372  AC A0A1M6KY46.1
#=GS A0A0A2THK4_9FIRM/244-381  AC A0A0A2THK4.1
#=GS A0A075TTL8_9CORY/270-409  AC A0A075TTL8.1
#=GS A0A0P8W8Z9_9CLOT/272-407  AC A0A0P8W8Z9.1
#=GS A0A4R5HEP5_9ALTE/113-252  AC A0A4R5HEP5.1
#=GS A0A133ZF81_9ACTN/165-288  AC A0A133ZF81.1
#=GS V7I435_9CLOT/272-407      AC V7I435.1
#=GS F8E196_CORRG/234-368      AC F8E196.1
#=GS A6C758_9PLAN/114-255      AC A6C758.1
#=GS A0A1Q5Q1V6_9ACTO/245-382  AC A0A1Q5Q1V6.1
#=GS A0A2V3ZRE8_9BACT/113-255  AC A0A2V3ZRE8.1
#=GS A0A401IA53_9BACL/120-259  AC A0A401IA53.1
#=GS A0A1I0EWZ7_9FIRM/256-391  AC A0A1I0EWZ7.1
#=GS A0A2N6ULV4_9ACTO/251-388  AC A0A2N6ULV4.1
#=GS A0A2C1Z4Z3_9BACI/124-263  AC A0A2C1Z4Z3.1
#=GS A0A6N8I458_9FIRM/142-277  AC A0A6N8I458.1
#=GS R6KKZ6_9CLOT/117-258      AC R6KKZ6.1
#=GS A0A1W6WG09_9FIRM/239-373  AC A0A1W6WG09.1
#=GS A0A2S1GYC6_9BACI/145-284  AC A0A2S1GYC6.1
#=GS A0A410DTU2_9CLOT/237-373  AC A0A410DTU2.1
#=GS N2BSS2_9ACTN/252-389      AC N2BSS2.1
#=GS A0A841KUX6_9CLOT/272-407  AC A0A841KUX6.1
#=GS A0A845H7R3_9BURK/123-261  AC A0A845H7R3.1
#=GS B0TCY6_HELMI/223-358      AC B0TCY6.1
#=GS A0A1V4IY40_9CLOT/243-379  AC A0A1V4IY40.1
#=GS A0A3N7C6A2_9BURK/113-253  AC A0A3N7C6A2.1
#=GS A0A1H6SDN2_9FIRM/164-291  AC A0A1H6SDN2.1
#=GS A0A1Y4NA57_9FIRM/235-372  AC A0A1Y4NA57.1
#=GS A0A4U7JAH4_9FIRM/243-379  AC A0A4U7JAH4.1
#=GS A0A060R6D5_9BACT/113-252  AC A0A060R6D5.1
#=GS A0A4V3EUF5_9CLOT/272-407  AC A0A4V3EUF5.1
#=GS A0A1W2EU78_9FIRM/126-263  AC A0A1W2EU78.1
#=GS R7CME1_9FIRM/239-305      AC R7CME1.1
#=GS G2T3Y2_ROSHA/113-252      AC G2T3Y2.1
#=GS A0A4Y1ZJS0_9BACL/111-248  AC A0A4Y1ZJS0.1
#=GS G4CU83_9ACTN/240-373      AC G4CU83.1
#=GS A0A2N6UXV7_9ACTO/235-370  AC A0A2N6UXV7.1
A0A5E4X1Z7_9BURK/123-261             .......................................q-QNVFSQYHLETEISEII.....ESLCKE..DAQFEES..SL...N-.EAKRVDEKLDGTITPFAKRKIKNNVTWFYLFIRERFADLER.SEPGKAVLISHQVKTFYLKQKMLTT.......NQQEIFENTVKWINSKYS..SASETAAEVIAAFYVQNCELF...............
V7I5Q9_9CLOT/252-392                 .......................................l-RVDVNDMTLEDDIQTVL.....DGLMSD..FDESELV..EL...SM.DALRIDQKIKPE-NHMLKNDEITRVLKYYNYINDLFSSMDR.DGTGDFDLIASEVNTAYKKLDNGRL.......TQEEIVDQLAEWIRNKSQvgSKFLRACHIVVAYFIQNCEVF...............
A0A4V6NGB1_9FIRM/126-263             .....................................lha---STMTLGLETEIEEII.....NKIVAL..SENEFT-..DL...NY.LAVPLANKFYPN-EVLLKIKVNGYVTTYFTYIHELFRTLER.TSNFDFEVLSMQIRAAFQKMNNTGA.......NKNEIFEAMNSWIGRKTT..NTCRSACEAITSFFVQNCEVF...............
A0A1C0BXL2_9FIRM/235-372             ....................................svhl----LDDLPLEKGIVGVI.....KKVKKL..GEKELV-..GA...SL.DPKEIKQKLSPTQDMALYIAVNGYVTTYYPRIREIMMNLDK.RGEIDYDEIQDQIHAFYKRLKKANK.......SRLEIFNEIAGKIHRVT-..LQDDIYCQIVVSYFVQSCEVF...............
K1LUB0_9LACT/240-380                 .....................................qik--EVSNSVKLEKDILEVI.....NNLSSI..DLSSIHT..DL...TL.NAVELKKKIHPE-NYMLIFDINTKVTSYYNTVRNIFSNLEG.EGIIVFEKIASQVKLYYLNLEEENI.......DQSQIYEEVTDWIHNSSG.gNSNRLACQIIAAFFVQNCEVF...............
A0A6A0B7F7_9LACT/253-388             .......................................l-QQVLAELDLEDEIKDII.....ESLANL..QSVGNLE..QL...SM.NALKIDQKILPE-NGLLKNSIQVNVLTYYRYIGSLFEEIED.-----LDIIQSEIKKAFKRLNTGDW.......NQQEIVDKLAQWILDKTKnpASHIEACRIIISFFIQSCEVF...............
A0A371IQ39_9FIRM/115-253             .......................................f-RNSLHENNIEDNIKKII.....DMLMEE..DIDDDF-..EE...KY.QAKKVDDKLNDTISKLTKRSIKSNVRLYYLIIQDKFRQLDE.ESDNTFKIIANQINTYYLKISRVSK.......SQEEIFKYLSNWLNNKTN..NYSSEACDILISFFIQNCEVF...............
A0A1I1X747_9FIRM/261-351             .......................................a-KASVKSIQLEDDIRTVL.....DALSQI..RDASEMV..QL...EY.DALHVEEKFEPE-NFILKNETQLQVVMYYRYIEKVLSESD-.---VDFDTIASEVKLS---------.......------------------..---------------------sqkl...........
A0A1I7L772_9BURK/83-221              ...................................qrriq-----YEYQIESDIATIM.....DALMSE..ATTEVL-..DA...DY.VAKEIDTKLVGEISNLTKQKIKNDVSSFYLFVRNQLAEIEK.TVPGQGVLIAMQVKLFYTKQKGLNL.......TQQQIFQNTVGWISSKTP..NGTEEAAAVVAAFFVQNCELF...............
A0A4D6B553_9CAUD/237-373             .......................................s-QQTLSAIQLDEGITEVL.....IRMNKL..KYDDY--..DI...SF.DPKELTDKIAIDQNRTLYNTVKNQVIDNYVTLDKILVSLDK.RGKIDYIEIQNQMRSMYKKLKKSNK.......DSLEIFNTISEKIHHAT-..LQDIYFCQMIVSFFIQKCEVL...............
A0A371ILA6_9FIRM/1-92                .......................................m------------------.....------..-------..--...--.----------------LKNDEMTRVLRYYNYIDELFSAMDR.DGTGDFDLIASEVETAYKKLDNGQL.......SQDEIVNALAEWIKNKSGvgGRNMRACHIVVAYFIQNCEVF...............
A0A0R2KH19_9LACO/237-370             ......................................se--ELLDPIHLEKGLTDVL.....SNLSKL..NPMTIS-..-V...SL.DPKEISQKVT---DPNLYLLVKNNVTTYFLSIKKIMINLDK.QGVIEYEILQNQMRTLYLKMAKTKR.......SEQEIFYEISNKIHKTT-..LANKLYCDIVVSYFIQSCEVF...............
A0A7H0SRI2_9CORY/269-407             .......................................l-RDAALEAQLHPAISDII.....EQLGEK..ILTGGAS..PL...RL.EAIPVARKIRPE-FYELSQRILILVLQWYRVVEQGFRELEG.KHRSRFTVIATQVADFYENACQVTD.......DQQEIFDAVASWIHTNSG..STNPNASRIVAAFFVQNCEVF...............
F8DZX3_CORRG/269-408                 .......................................l-QDTALDSQLHPAIASVI.....ETLGER..IVTGVIP..EL...TL.DAVRVAEKVRPE-YFELAERIKIHVLKWYRIIEQEFRSLEGvRGRSRFDAIAGQVADFYDQASQHTD.......DQQAIFDQVADWIHTNSD..SVNLSASVIVTCFFVQNCEVF...............
A0A8J2ZXD4_9BACL/272-407             .......................................a-RDATSRYTIEKQIEQVL.....REVELM..DATDDT-..QL...KI.EPVKVENKITE---KRLKDRVLFDVRQLYEGVNDSLYRLAG.ENSLNVDKFARNVRRMYEDASESRI.......SQSEIYYLLVETLFEKTG..RKYRGACEIIISYFVQRCEVF...............
E7MNK2_9FIRM/113-252                 .....................................lkn---TYALFNIEEEIKEIL.....KNLNDE..SLEEDLV..RL...SY.ESLKIEQKANDTLPFAIKRTIKNDVVDYFDYIHKIFIEMDK.VTPYKFDTLAAQIKGFYCKTMQINP.......NQEFVYASLVDWLNEKTG..SYSRRACEIVIAYFIQDCEVF...............
A0A6P1IYE8_9BURK/114-254             ......................................an--ATISDYTIQQEVYAIL.....DSISSL..TSSELDI.pPA...NF.DATTVDKKLHTGMSPLQRLEIKTYAVTFYVRIRDQIRMLEQ.NDQAAIRLLQNQINTYYLAMQQQNP......dNKDAVFNFVAQWISTRT-..RRPLLAAKVLTSFFVQNCEVF...............
W4TFX4_CUTAC/17-140                  .................................khatahr------------------.....-SIHNL..PIEDLAP..DA...TY.DVMQMQAKLD---DVKLVRRARDHMSIYESVVREEAKSLGE.AGNLDFERMRDDIWDACRVLIDAGL.......SHDEVWARLTEWIDQHT-..QVDEYACGVVVSLLTQICELF...............
D9QBJ5_CORP2/234-368                 ..................................deglap-------LGLDRKISQLL.....AVINQL..PFEEVVR..DT...NY.SVVKLKEKIDD---MALLRLCFDAMATYEPVVRNSAMALEA.QGDFKFSKMRRQIQSAWDVLDDSGM.......SQYDIWQRLTAWIHEHT-..EVDRYASGVVVAFMIQI----gdlf...........
A0A1U7MJI1_9FIRM/117-256             .................................vkstyvi-------FNIEAEIREIL.....EKLNTQ..SLESELV..QL...SY.ESLKVDQKTNDTLPFAIKRSIKRDVVDYFDYIRRLFIEIDK.VTPYKFNTLAAQIKGFYYKCMQVNP.......NQEYVYNSLVDWIDEKTD..SYSRKACEIVVAYFIQDCEVF...............
A0A0F4KR17_9LACO/263-403             ..................................lenqli------GINLEHEVAQVV.....EKIANL..HQQSTDD.iDL...VM.NPVSVKEKLPQ--NYLLQREITNQVQYYYNIINREFINLSR.TDGIEFDEVCEEVRFAFIKVKKFKE.......TKEEQFEAMVDWMQQTLGfyDDRRLACKCVTSFFVQNCEVF...............
A0A0R2FTM8_9LACO/282-420             .......................................i-AQDLNQLTLEAKLTKVI.....QGLKKV..KPNLANS..IV...DY.DAHTVEEKISH--DYALQGAVSYYVSGYYNKIKDQFSNLEG.-PDFSFDELATTIKLAYFKFKREQL.......DQEEIFNHLADWILTKEQlpQDYSEASRIIVAFFVQNCEVF...............
A0A412AXM5_9FIRM/260-396             .......................................a-KLSVSDVQLEDDIRTIL.....SALGTI..KNASELV..EL...EY.EALRIDEKFDAE-NFILKNETQMQVVTYYRYIEKVFSNSN-.---ADFDMIASEIKVSSMKLEKAGL.......SQQDVIRQLSEWIRNKAGlgTESLLACNIVVSFFIQNCEVF...............
A0A1I4QPU9_9BACL/117-256             .....................................ygq----FNAYKIEEEINVVL.....EMLVSE..VPSDLEE.nKL...KY.DALRVSEKADTTLTALTRRDIENDVVDYYITIKQRFVDLNK.SRTGSFDLLSSQVKTFYTELKVSGI.......SQEDIFDGIIEWFNKKTN..NHSRPACRIIASFFVQNCEVL...............
A0A4Q0T8C2_9BACT/50-190              .....................................qrs---LRGDYQLEASIDEVI.....SLLGEV..DFSDENT.nNL...QF.DAKSLDQKFDASLPGPTRRKIKHHVADYYSHIKRGFRDLEM.QTPMASEVIYTQVRSFYKKQKSLGL.......SQPEIFLNIVLWLRSNTA..SHSFDAPEIIASFFVQNCEVF...............
A0A0L6Z9C9_9CLOT/272-407             .......................................a-RDATSRYTLEKQIEQVL.....REVDLM..DVTDDT-..QL...KI.KPVKVENKITE---KRLKDRVLFDVRQLYEGVNDSLYRLAG.ENRLNVDRFAKSIRRMYEDASESHI.......SQSEIYYLLVETLFEKTG..RKYRGACEIIISYFVQRCEVF...............
A0A2V2NB83_9EURY/123-263             ..................................fhklcg------KSFLEKEIIDVI.....NSLNEK..NWDECDI..GL...DY.TALKIDQKLDFDFNFILKNQIKFNITSYFLLIKHLFSEIDK.LSPGKFKIISQQIKLFYYSLLPSTK.......NQEDIYNQMADWIKLESN.nTGSVDTCKIIISFFIQNCEVF...............
D0Z2M1_PHODD/116-256                 ......................................lt--DTWDNQTLHKDIALVA.....ERIDQL..DASTLED.tKL...SF.DALKVSDKTDDTFGQLNEMKVSMFVVNYFANIKESLKRLEM.QRKASSLVICNQVRSYYSMLLFQDF.......NQNDIFEQMCDWFMVNTG..IKERTKAEVLVSYFIQHCEIF...............
A0A1H3ZXE1_9FIRM/236-373             ......................................sm--QLLDSMPLEKEIIGVI.....SKIKNL..KEKDLL-..DP...SL.DPKDIREKLSPDENFALYNTVKGYVDTYYVTLKEIITNADK.RGEIDYEEVQDQMKAIYKRLHKAGK.......SNVEVFNEISEKIHKVS-..FQEDFYCQIVVAFFIAKCEVF...............
A0A1H0JAT3_9PSED/114-254             ........................................ARKSISEHSLREEIKELI.....EKISNL..DDESLIS.fDL...QL.NASTLSEKLKKGASPVLRRNIRNDVVDYFVTIQDELRLLEQ.RDQAAVKMLLNQVNTYFWAMHSEHP......dNKDAIFNYIAQWISAKS-..GKSIDASRIVTSFFVQNCEVF...............
A0A369BH46_9BACL/113-250             ..................................lrstyy------LFNIESEIVVVL.....EKLQTI..DGDITT-..-L...SY.ESLKIDEKTNDSLPFILKRKIKNDAVDYFDFIRNIFVTMDQ.VTPHKFDTLASQVKSFYWKCMQTDT.......NQEYIYNALVKWLDEKTD..HCSRRACEIVIAFFVQDCEVF...............
A0A140L450_9CLOT/272-407             .......................................a-RDATSRHEIEKQIEQVL.....REVDLM..DVTADT-..QL...KM.EPIKVENKITE---KRLKERVLFDVRRFYEGVNDTLDRLAG.ENKLNVDRFAKSIKRMYEDASESQI.......SQSAIYNLLVETLFEKTG..RKYREACEIIISYFVQRCEVF...............
A0A1I7JU69_9FIRM/210-347             ......................................sv--QLLDNMALEKGIIGVI.....GKIKDL..KQKDLV-..GA...SL.DPKEIKQKLDPDKDLAIYGVVNYYVNTYFLKVKEIMMSLDK.RGIIDYEETQDQMKAFYRNLKKKKL.......TKVEIFNEIVDKIHRVS-..LQENIYCQIVVAYFIQSCEVF...............
I0HWB8_RUBGI/113-253                 .......................................q-RSLASQYPLELQIAAVV.....AHLHSA..SVEETGD.aTL...AF.TPKAVDDKLDATMPPPTKRKVRNAVEDYFRHVQAAFLELER.SDPGCSELIFVQVKAFYLMQKRQGL.......PQSQVFANLVDWIRARAK..AQTLESAEAVASFFIQNCEVF...............
A0A3E2N9J4_9CLOT/328-471             .....................................ldr----ISGIKFQDEIETVL.....REVHKT..KNAQGLE..PT...DIkDLVEIERKIH---EPFLKDKINASMARLYKTVKNTCSRLEQ.EIGFDTNMFGELMKSAYKLLESGIQqksdiidPQEYIADLLVEKLFSQVG..QRHRDACEIIVGYLVKRCDLF...............
A0A7T3V5D3_9SPIR/142-292             ..............................lditnkdeyl------QKELEQVVKSILlweknDNLSMA..DKIELDKntEL...NY.DPVVVEKKLYDV--KSLKTVVLANVTEYYKMIKSFFLAEQK.KSSEQAEYVSKTVKNKYLKVKAIAK......gDKHEIFKRMKIFIQDKTE.nYDNDEILNIIVSYFIQSCEVF...............
B9YD47_9FIRM/279-415                 .......................................s-RELVATQKIDEGVRRVL.....EKIPSI..SKPRDV-..DL...NY.DPVALRQKIEAK-NLLLYVRTQAQVNIYFNAVHEIFQQLSK.EGKLRFKPFCNQVKITYLNLKDKGY.......DQQRIFDEMVDWLQTST-..NEERGSCEVIISYFIQKCEVF...............
D6ZG28_MOBCV/246-383                 ........................................ARQTLSAVQIERGITRVV.....ENLARA..NPKEFE-..PL...NF.DPVAVKNKIDEFSDFFLFDEVMQHVTKFFRFIQNQLKEQAR.LKAFDEELLRAQIKASYRKLADKKF.......DKLVIHDELSKRLSQLT-..KQDQRYCSYVVSYFVQSCEVF...............
A0A448PFZ5_9ACTO/244-385             .............................nevfsagtapq------------DLGRVV.....RALAEA..PDPHAPE..EVspdKF.EATAVSRKIRPE-YYALCLTIKTLAEAYYYKVGSLFTALDD.GEERAYRRIRTKVRAIYDDAVEVTD.......DQQLIFNDFVDWVAKQAD.vPTRSQGALIVAAFFVQNCQVF...............
G5KI97_9STRE/237-373                 .......................................s-QQSISDMKLDSGIVSVL.....TSLNKL..KFDEY--..DI...SY.DPKQLTDKISPENNRTLYQLVKNQVIDNYLTIQKIIINLDK.QGRIDYEDIQYQMRSMYKKLKAAKH.......GNLEIFNTISEKLHKAT-..LQDIYFCQMIVSYFIQKCEVL...............
Q9A0Y9_STRP1/227-363                 .......................................s-QQAISDMKLDSGIVSVL.....TSLNKL..KCDEYN-..-I...SY.DSKQLTDKISPENNRTLYQLVKNQVIDNYLTIQKIIVNLDK.QGKIDYEKIQYQTRSMYKKLKAAKH.......NNLAIFNTISEKLHLAT-..LQDIYFCQMIVSYFIQKCEVL...............
A0A5C4SR66_9FLAO/154-174             ......................................re------------------.....------..-------..--...--.---------------------------IYEFIKDELG----.-------------------------.......------------------..---------------------edvdivkld......
R5EH97_9FIRM/128-265                 .....................................lse---ATLTMGLELQIADVV.....KRICAL..HEDEMA-..TL...NY.EPVRLTKKFSAT-EVLLKNRIGTYVTSYYPYIRDCFKELEG.INGFRLDALSLQIKSCFIKMEGLSD.......NKSDIFDQLVNWVMAKTC..STSREACEAIVSFFVQNCEVF...............
A0A0A2T6S8_9BACI/112-252             .......................................t-RAKYHDYQIETEIKEVI.....TVLVEE..EFHEDTP.nEL...EL.NALKLNEKANETLTKITKRRIRNEIREYYLYIQQQFIILDS.QYPESFNRIALQVKLFYSILRKSES.......SQEVIYGQLTEWLSKKTG..NSSLGACGIIISFFIQNCEVF...............
A0A6C1B994_9RHOO/114-254             .......................................a-RTTAAQYAIQEEIYTIL.....DNIVAL..DGDAPEI.sPA...RF.DISTVDKKLRVGMSPLQKHEIKMYAVNFYVRIRDHIRLLEQ.NDQLAIRIMQNQINTYYLEMQKQHP......dNKDAVFNFVAQWISSRT-..GRSLLAAKVLTSFFVQNCEVF...............
R5CJN2_9FIRM/101-245                 qheqwvtkkleeksisysfaelevlakylvsstasaqats------------------.....------..-------..--...SF.SLLKIDEKIKKNSLLDVQRYITMGLSSNF-TIEDYLNRHP-.-DPLFAAKLTNIMAQKYRELKSNGL.......DNCEIFDELWNFASGNNS.dFSYKAAGLGILTYFFEKCEVF...............
A0A3A9HZ41_9FIRM/222-362             .......................................l-RVDINDATLEDEIQNVL.....YGLAGI..TDDTELE..EL...SL.DALRLDQKILPE-NRLLKNDETTRVLRYYNFIDNLFSAMDR.DGTGDFDLIASEIEVAYKKLDTGQL.......SQDEIVEQLAEWIKNKSGvgNRNMRACHIVVAYFIQNCEVF...............
A0A7Y8KY76_9BURK/114-254             ......................................ak--LTASQYVIQSEVCEIL.....DAIVGF..DFDDLNL.gSP...NF.DVATVDKKLKTGMSPLQKHEIKQNAISFYVRIRDHLRFLEQ.QDQVAVRILQNQIKTFYLEMSKQNP......gNKDLVFNYVAQWISDRA-..GKPILAAKVLTSFFVQNCEVF...............
A0A433HAV6_9BACI/112-251             .......................................t-RAKYADYQIESEIKEVI.....TMLVEE..FNEGALK..QL...EL.KALKLDEKANETLTRITKMRIRNEITEYYYYIKEQFVQLDS.QYPKSFNHIASQVSAFYNSLSRIEP.......SQEVVYGQLTEWLSKKTG..NSSLGACGIIISFFVQNCEVF...............
A0A1I3SA24_9BACL/113-252             .......................................t-RAKYADYQIESEIKEVI.....IMLVEE..FNESALK..QL...EM.QALKLNEKANETLTRVTKMRIRNEITEYYYYIKEQFAQLDS.QYPRSFNAIASQISAFYNSLSRIET.......SQEVIYGQLTEWLSKKTG..NSNLGACGIIISFFVQNCEVF...............
A0A1M6KY46_9FIRM/235-372             ....................................sirl----LDDLPLEKGIVGVI.....KRIRKL..GEKELS-..DA...SF.EPKEVKQKLSPSQDMVLYNAVTNYVTTYFIRIKEIMINLDK.SGEIDYDEIQDQIHALYKKLKKANK.......PHLEIFNEIADKIHRVT-..LQDAIFCQIVVSYFVQSCEVF...............
A0A0A2THK4_9FIRM/244-381             .......................................t-RRTLDEVAIEKGIAQVI.....ENLSKA..QPGQLL-..AL...NY.DAVSVTEKIDEELHSFLVYEVTGHVARYFLFIEKTMQDLVR.RKQFSDDLLRAQIKESYRKLAEKKN.......SPEMIYSALSERFRSIT-..KQDIRFCSIVISYFIQSCEVF...............
A0A075TTL8_9CORY/270-409             .......................................l-QDLALDAQLGPAISDVI.....ETLGER..IMSGNVP..DL...TM.DAVRVTDKIRTE-FYELAGRIRIHVLQWYRIIEHEFRALEGvRGRSRFDAIAGQVADFYDQASQHTD.......DQQAIFDHVADWIHTNSD..STNLNASVIVTCFFVQNCEVF...............
A0A0P8W8Z9_9CLOT/272-407             .......................................a-RDAASRHTIENQIEQVL.....REVDLM..DVTADT-..QL...KI.KPVKVENKITE---KRLKEQVLFDVRLLYEGVNDALDRLAG.ENKLNTDKFAKNIKRMYEDASESHI.......SQSDIYTLIVETLFEKTG..RKYREACRIIISYFVQRCEVF...............
A0A4R5HEP5_9ALTE/113-252             .......................................q-EEIWSRYSIEAELGIVI.....DALYSD..PNIDIES..DL...EF.TPKTVDEKLDETITRPTHRKIKTQVRDYYVFIKEKFSILDQ.SEADLSETISLQVKTYYLKQKRLGL.......DQQEIYENIVAWINAKTK..PKTMDASEIMASFFVQNCEVF...............
A0A133ZF81_9ACTN/165-288             ......................................lg--QDVDCVKIESNLAKVI.....NILAEE..TLDINAG..SP...EI.NSFAIEDKILF-NDLEYAKDIIDEYKIFYHRLDEIYSEFDR.EGKNKSFSVLQEIRRQYIELNRLNY.......TPTDIFYEIINCV-----..---------------------ikviigssnyi....
V7I435_9CLOT/272-407                 .......................................a-RDAMSRYTLEKQIEDVL.....REVHLM..DVTNDT-..RL...RI.KPVKVENKITE---KRLKERILLDVRQLYEGVNNSLDRLSG.ENKLNVDTFAKNVKRMYEDAAETLT.......SQSDIYNLLAETLFEKNG..YKYREACQIIISYFVQRCEVF...............
F8E196_CORRG/234-368                 ..................................deglap-------LGLDRKISQLL.....AVINQL..PFEEAVR..DT...DY.SAMTLQQKIDD---MALLRLCFDAMATYEPVVRNTAKALEA.QGDFKFSKMRRQIQSAWDVLDDSGM.......SQYNIWQRLTAWIHEHT-..HVDRYACGVVVAFMIQICDLF...............
A6C758_9PLAN/114-255                 ......................................qe--LLWKQFGIESELISII.....ESLYEL..DITEIDNsvDI...GY.DPKTINDKTNQSISRPTVRKIRNNVTDYYSFIKSQIAILDK.SNAEFSNLVSLQIKSFYTKQKQQKI.......SQQAVFDNIVKWIQMKTK..PQSKDGAEIITSFFIQNCEVF...............
A0A1Q5Q1V6_9ACTO/245-382             .......................................a-REVASTVDIERGITKVI.....EKLGNA..KLQDFE-..PL...SF.DPVAVKAKIDESIDFFLYDEVMRHVTKYYRFIEGQMQEEAR.LKTFDDNLLRAQIKALSKKLVEKGY.......PKMRIHADLSDRLSQIT-..KQDIRYCAFVVSYFVQSCEVF...............
A0A2V3ZRE8_9BACT/113-255             .......................................e-KELWKNSKVEDEIYQII.....NFLSEN..DLNLMDN.iEL...NY.DPKKIDDKTDDSITFLTKRLIKLNVQDYYHLIKEKFSEIDL.EIPLTTETISSQIKSHYLTLRKQNVn.....sTQKMIFDGMVSWLYKMTN..QTSFAASEIIISYFVQNCEVF...............
A0A401IA53_9BACL/120-259             .....................................aki---STSHQDIEDEIVLVI.....NSLMSI..DPVSLQK.mEL...EY.KALKISSKIEMT-YSILKAKIETYVCIYFNLIKETFQSLDQ.ENKINFDLVASEVRASFLKCDEEII.......SKSEIFEALVKWLKSKSN..GSSSEACEAVISYFVQSCEVF...............
A0A1I0EWZ7_9FIRM/256-391             .......................................a-QKSIDRMELEEDIRIAL.....AALMEI..KNPSKMI..GL...DY.KALRIDEKIKN--EPLLKNEVQNHVLQYYRTIEGAFNDSE-.---ADFDTIATEIKLSSLKLEKAGL.......SKEDVIESLAEWIRKKANlgDRSRTACRIVVAFFIQNCEVF...............
A0A2N6ULV4_9ACTO/251-388             .......................................a-RKTLTTVDIERGISKVV.....EKLGNA..NPKEFE-..PL...NF.DPVAVKDKIDQSVDVFVYDEVFMHVTRYFRFIEKELQEQAR.LKTFDDGLLRAEIRASYTKLADKGY.......AKQRIHEALTIRLSQIT-..KQDARYCAYVTSYFVQSCEVF...............
A0A2C1Z4Z3_9BACI/124-263             ......................................tr--AKYIDYQIETEIKEVI.....AKLVEE..FNEGAIK..TL...NM.SALKLDEKADETLSRITKSRIRNEIIEYYLYIKEQFAQLDS.QYPKSFNAISSQVKSFHDSLSRKES.......SQEVIYAQLTEWLSKKTE..NSSLGACSIIISFFIQNCEVF...............
A0A6N8I458_9FIRM/142-277             .......................................a-RDATSRYVIEKQIEQVL.....REVDLM..DVTDDT-..QL...KI.EPVKVENKITE---KRLKDRVLGDVRQLYEGVNDSLYRLAG.ENSLNVDKFARNVRRMYEDASESHI.......SQSEIYYLLVETLFEKTG..RKYRGACEIIISYFVQRCEVF...............
R6KKZ6_9CLOT/117-258                 .......................................c-RELYGNYAIDDEINVVL.....NLLARScsQSNTVKE..EL...VM.SAMRIDEKADDSLELITKITIENYVRIFFPEIKNKFIELDN.NDEGIFDIIALQIKVFYLQIKKINN.......NQTIIFEQIVEWIHQRTG..KKSRIASTIIASFFVQNCEVF...............
A0A1W6WG09_9FIRM/239-373             ....................................dqei----RADQHVQEGVRRVI.....EKIPFI..KPPTDI-..DL...NY.DPVPVRQKIS---DFALYLRIKTDVNVYFNDAHEVFQEMGR.EGKLRFNPFCQQVRYMYVSFRDKGY.......SQDKIFYEMTKWLYDAT-..NEKWRDCEIVIAYFTQKCEAF...............
A0A2S1GYC6_9BACI/145-284             .......................................a-RVAVSHQDLEDEIILVI.....NALSHV..NMRSLEK.mKL...EY.NALKISNKIDES-YVILKNKIESYVCTYFNFIKETFRNLEA.SGQLNFNIIASEIKTSFLKCEKELL.......NKGDIFNSMVNWMNSQLG..NSSYEACEVVVSYFVQNCEVF...............
A0A410DTU2_9CLOT/237-373             ....................................tiev----LANTKVEEGVERVL.....RKISDT..PMMKLI-..PL...SY.EPVSLREKILPE-NRSLYIKAKAYVTEYYPAVHGIFQQLSK.ERKLRFDPFCMQVKMNYINLRDKGL.......TQPEIFEALVEWLASNT-..NDRKDLCEIVISYFIQKCEVF...............
N2BSS2_9ACTN/252-389                 ......................................le--AAINDINLGGQISAAV.....RKLSDA..DLTADAS..Q-...VF.TAVSVDRKFNESLYEEEKDQIRNSVIKSYIKVHAELTVLCQ.SGECDWDVLRSKMHGLYVQLKLKTE.......NQSKIFNTICSTIQKAG-..KCRQSISIILTSFFIQMCDIF...............
A0A841KUX6_9CLOT/272-407             .......................................a-REATSRYTIEKQIEQVL.....REVDLM..DVTDGT-..QL...KI.QPVKVEKKIVE---KRLKERVLFDVRRLYQGVNDALDRLAG.ENKLNVDKFAKNVKRMYEDANESQL.......SQSAIYNLLVETLFEKTG..RKYREACEIIISYFVQRCEVF...............
A0A845H7R3_9BURK/123-261             .......................................q-RNIFLQYALEREISEII.....DSLCDS..SVDFEM-..GS...NF.EAKRVDRKLDSTIRPLTKRKIKNDVSSFYLFVRERFSDLER.ADPNKAVLVAQQIKSFYLKQKTICS.......NQQEIFDNTVRWIQSKHT..AGSTPAAEVIAAFFVQNCELF...............
B0TCY6_HELMI/223-358                 .......................................a-RDATSRYALEKQVEYVL.....REVQLM..DVTDDT-..RL...KI.EPVKVERKITE---KRLKERVLFDVRQLYEGVNNALDRLSG.ENKLNVDRFAKSVKRMYEDASEKLT.......SQSDIYNLLADTLFEKTS..RKYREACKIIISYFVQRCEVF...............
A0A1V4IY40_9CLOT/243-379             ......................................ai--EALADSKIEEGVNRVL.....RKISTT..PFTELI-..PL...NY.DPVEVKRKIKRD-NVPLFIKIQSSVNIYYLYVENLFQQLSK.EGQLRFEPFSMQVKLNYWNLRDQGL.......SQSDIYYKLVDWLAKNT-..NESKEPCEVIISYFVQKCEVF...............
A0A3N7C6A2_9BURK/113-253             .......................................q-RSLASQYPLEQQIAAVV.....AHLHSA..AVEGAES.aEL...SF.TPKAVNDKLDATMPPPTKRKVRNAVEDYFRHVQAAFLELER.SDPGCSEQIFVQVKSFYVMQKRQSL.......PQAQVFANLVAWIRVRAK..AQTLESAEAVASFFIQNCEVF...............
A0A1H6SDN2_9FIRM/164-291             .....................................lgn---DVSYQKIESNLATVL.....NILSSE..VMKIEVA..SP...EI.NSFAIQDKIDF-NELTGVQEIIDDYKIYYHRIDEIYNEFDR.EGKIKRYSVLQSIKTQYIKARNEKN.......DATDIFLLTIEKV-----..---------------------mniisassnfvtipi
A0A1Y4NA57_9FIRM/235-372             ....................................svhl----LDDLPLEKGIVGVI.....RKVKKL..GEKELV-..GT...SF.DPKEIKQKLSPSQDMALYIAVNSYVTTYYPQIKEIMMNLDK.RGEIDYDEIQDQIHAFYKRLKKANK.......SRLETFNEIAGKIHRVT-..LQDELYCQIVVSYFVQSCEVF...............
A0A4U7JAH4_9FIRM/243-379             ......................................ai--EALADSKIEEGVNRVL.....RKISTT..PFTELI-..PL...NY.DPVEVKRKIKRD-NVPLFIKIQSSVNIYYLYVENLFQQLSK.EGQLRFEPFSMQVKLNYWNLRDQGL.......SQSDIYYKLVDWLAKNT-..NESKEPCEVIISYFVQKCEVF...............
A0A060R6D5_9BACT/113-252             ......................................gr--RNLLKLDLEDEIIDII.....RKISSL..NDDELTEdiKL...NY.DAIKVDRKIDPK-YKVLKRRIKDDVSLYFGVVRREFETIDC.LGLRKFEQISYQMRNAYLKISEREK.......DKEKIFNHLVSWLKLKT-..ETEDCICQVIISFFIQDCEIY...............
A0A4V3EUF5_9CLOT/272-407             .......................................a-RDATSRHEIEKQIEQVL.....REVDLM..DVTADT-..QL...KM.EPIKVENKITE---KRLKERVLFDVRRFYEGVNDTLDRLAG.ENKLNVDRFAKSIKRMYEDASESQI.......SQSAIYNLLVETLFEKTG..RKYREACEIIISYFVQRCEVF...............
A0A1W2EU78_9FIRM/126-263             ......................................lh--DSTLTLGLETEIEEII.....KKIVAL..NENELA-..DL...NY.LAVPLANKFYPN-EVLLKIKVNGYVTIYFTYIHELFRNLER.TSNFDFEVLSMQIRAAFQKMDNTDA.......NKNEIFEAMSSWIGRKTL..NTCRSACEAITSFFVQNCEVF...............
R7CME1_9FIRM/239-305                 ....................................dqei----RADQHVQEGVRRVI.....EKIPFI..KPPTDI-..DL...NY.DPVPVRQKIS---DFALYLRIKTDVNVYFKA----------.-------------------------.......------------------..---------------------wrfdt..........
G2T3Y2_ROSHA/113-252                 .....................................lkn---TYALFNIEEEIKEIL.....KNLNDE..SLEEDLV..RL...SY.ESLKIEQKANDTLPFAIKRTIKNDVVDYFDYIHKIFIEMDK.VTPYKFDTLAAQIKGFYCKTMQINP.......NQEFVYASLVDWLNEKTG..SYSRRACEIVIAYFIQDCEVF...............
A0A4Y1ZJS0_9BACL/111-248             ...................................lhdat-----FTLGLEYEIENVV.....EKIYGL..KESDIS-..GI...NY.NAVAIADKFISD-EILLKSKITGYVMTYFTFIRDLFKNMET.TTTFDFDILSGQIRACFIKMDSSGA.......DKVEIFENMVDWINNKTQ..NISRIACEAIISFFVQHCEVF...............
G4CU83_9ACTN/240-373                 ..................................eglvpl--------GLDGKIAELL.....KAIHNL..PVEDLAP..DV...TY.DVMPMQAKLAD---TKLVRRVRDHMSIYETRVRQTAKALQE.AGQLDFERMRDDIWGAWRVLADAGL.......SQDEIWTRLTAWIHQHT-..NIDDYACGVVVSFLTQICELF...............
A0A2N6UXV7_9ACTO/235-370             ..................................ladnvv------PLGLEKEISLLL.....DAVSNI..PYEQRIP..DS...KF.KAVDLEQKIHD---ADLLSQATDAVSVYKPFIVTQLKSKEA.REQLKFTRLCNQFQGAWLTFESSGL.......DQPGQFRQLCDWMNNHT-..GSGIYVCGILISYFIHICEVF...............
#=GC seq_cons                        .......................................t....hsphplEppIppVl.....cplsph..s.pphh...pL...sa.-slplcpKlstp.phhLppclpspVppYY.hIcchhppL-p.psphsh-hlspQl+shYhchpptph.......sQpcIasplscWlpppT...ppshtACplllSaFlQsCEVF...............
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