#=GF ID   CTD8
#=GF AC   PF20284.2
#=GF DE   C-terminal domain 8 of the ABC-three component (ABC-3C) systems
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Aravind L
#=GF GA   27.60 27.60;
#=GF TC   27.60 34.40;
#=GF NC   27.20 27.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   32894288
#=GF RT   Comprehensive classification of ABC ATPases and their functional
#=GF RT   radiation in nucleoprotein dynamics and biological conflict
#=GF RT   systems.
#=GF RA   Krishnan A, Burroughs AM, Iyer LM, Aravind L;
#=GF RL   Nucleic Acids Res. 2020;48:10045-10075.
#=GF DR   INTERPRO; IPR046912;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   C-terminal domains (CTDs) of ABC-3C systems, contain distinct
#=GF CC   patterns of charged and polar residues and are not yet unifiable
#=GF CC   with known domains. These domains are found at the C-terminus of
#=GF CC   the effector component of the systems, which are upstream of the
#=GF CC   Middle Component and ABC ATPase components on the genome. Due to
#=GF CC   the typically large size of these CTDs relative to the actual
#=GF CC   effector and MC domains, the CTDs are predicted to serve as the
#=GF CC   platform on which the remaining two components assemble.
#=GF CC   Therewith, conformational changes transmitted by the ABC
#=GF CC   ATPase-mediated detection of invasive elements like DNA viruses
#=GF CC   would result in an unfurling and activation of the
#=GF CC   CTD-associated effector [1].
#=GF SQ   13
#=GS A0A401UP54_9CLOT/183-305  AC A0A401UP54.1
#=GS D5V5X7_ARCNC/260-386      AC D5V5X7.1
#=GS A0A0Q5PE98_9BURK/269-394  AC A0A0Q5PE98.1
#=GS A0A4Y9SZ31_9BURK/268-396  AC A0A4Y9SZ31.1
#=GS Q1WSD2_LIGS1/23-147       AC Q1WSD2.1
#=GS A0A345IZR0_9PROT/261-387  AC A0A345IZR0.1
#=GS A0A161WHY6_9CLOT/2-122    AC A0A161WHY6.1
#=GS M7P389_9GAMM/268-394      AC M7P389.1
#=GS A0A1L3MPA0_9BACI/267-394  AC A0A1L3MPA0.1
#=GS A0A084JEJ9_9CLOT/3-106    AC A0A084JEJ9.1
#=GS A0A7R7AJH9_9GAMM/260-385  AC A0A7R7AJH9.1
#=GS A0A1S2QWR7_9BACI/267-394  AC A0A1S2QWR7.1
#=GS A0A4Y9RI17_9BURK/160-288  AC A0A4Y9RI17.1
A0A401UP54_9CLOT/183-305             .sdlg----YDDCIFIKKLECAHIFEKE--MCMKEFFNAE.IAKS.TIESKGN...LKDLkvyRQLKSKIHSIWYPQYMQYADEI--DGN..ILLAKTYERIEEFDTTTLHT-I.D.DISLIAKKGMLHQLSNECK--------vgwikn
D5V5X7_ARCNC/260-386                 .....TDSKYDDEYFVLKLLIADVHQSIVKNSKKHFYYSE.AIRK.IFTSKQD...LLIL...KELYAKIESIYFNTYALFTSKKIDSST..ELVSIVHDKIIEKEKDFLATEL.S.KINGLHKQGMIHQLANDMSKDISWSDP......
A0A0Q5PE98_9BURK/269-394             .....DPSQYRDETFVLKLMLADVHNAAVKHSKEHFLNAE.YARK.LFSSAAD...QERL...RTIYDRIRTLYQNCYENFVSRG-GDST..LLVNEVHQKIVLEDANYLKTAF.P.MLQGLHKMGMLHQIANDLQDDVWWSEN......
A0A4Y9SZ31_9BURK/268-396             ...sd--AELADEYFVLKLMLADVHVSTIRHCKENFLNAE.YTRK.LFSSRTD...QEKL...AQLYERIRTLYHDSFDKFINSKSPKKTpgELVAEIHEKIVHQDDGYLKSAL.P.VIHALHKKGMLHQLANDLEGDVWWSEE......
Q1WSD2_LIGS1/23-147                  eisem----YNDIIFISMLKSAQ--IADVDDFKVDFYNAE.IARH.ESLSKDDingKKQY...DNLRMKIHSIWKTQYRLYKQP--NDGN..CLINQTYLRIEDLDSSTLGSSI.S.DFNLLAKKGILHQLADD--KELGWVD-n.....
A0A345IZR0_9PROT/261-387             ..mse---EYNDEYFVVKLLIADVHNSLVDDSKKHFYYSE.EIRK.IFTSSSD...RKIL...QELYAKIESLYKNFYGDLITKKITSSN..ELVNEIHKKIIEDDRDFLNTTL.S.KINGLHKKGMIHLLANDLKRDIFWDEN......
A0A161WHY6_9CLOT/2-122               ..ega--------LFVKKLKKEEIDNETIGYSKKTFFYADgYIRK.LEKYNLP...IEVV...EDTFSNCYNVYSDIRYRMYRKN-KNSQ..KLVEEVMDNL--SDYNFSSLNLyA.QPKSVQKTGIIHILANDGKRDVFWGE-v.....
M7P389_9GAMM/268-394                 .....DETDFDDELFVLKLISADIHKTTIREAKEAFLNAE.YIRK.IFSSSSD...KKRL...AELYAKIRKVYQNSYTKYIHDGIPNSG..LLLADVHETIIKQDKKFLDTFI.L.FINAIHKQGMLHQLANSKDENIWWIK-d.....
A0A1L3MPA0_9BACI/267-394             .....DIGQYDKEIFVIKLILADVHKTVIGSSKETFYNAE.YITKyLLSQKIN...MSHL...EALYTKIKHLYTIHFGELLSGKIKDST..ELVTVLHGQILKQDRNFLKSSL.T.MIDALQKTGMLHQLANNLDSEIMWAKE......
A0A084JEJ9_9CLOT/3-106               qsdiv---------------------------KRLFFYADgYIRK.LEKYNLP...IEVV...EDTFSACYNVYSDIRYRMYRKN-KNSQ..KLVEEVMDNL--SDHNFSSLNL.YvQPKSVQKTGIIHILANDGKRDVFWGE-v.....
A0A7R7AJH9_9GAMM/260-385             ...dg--NEFDEEYFVLKLVIADVHETITGHAKEYFYNAE.LARK.IFTSDSD...RKNL...DTLYKRIKHLYQEEYEKYLVNK-DTSD..SLVSSLHSRIMSEEGSYLKDLL.K.GAESIHKKGMLHQLANKKDKIILWSD-k.....
A0A1S2QWR7_9BACI/267-394             .....DDGKLDDEIFVLKLLIADIHKSLIDDSKQTFFNAE.YMIRaLISKGYN...LDDL...NELYSNIERLYRIYFVKFIEGEIKSSN..ELVVKIFENIIDRDKEFLKSTI.P.LIDANKKTGMLQQLANNLDKEIWWAKN......
A0A4Y9RI17_9BURK/160-288             ...sd--AELADEYFVLKLMLADVHVSTIRHCKENFLNAE.YTRK.LFSSRTD...QEKL...AQLYERIRTLYHDSFDKFINSKSPKKTpgELVAEIHEKIVHQDDGYLKSAL.P.VIHALHKKGMLHQLANDLEGDVWWSEE......
#=GC seq_cons                        .......spasDEhFVlKLhlADlHpohlccuKcpFaNAE.YhRK.lhoSpsD...hcpL...cpLYs+I+slYpspatcalspp.ssSs..cLVsclH-+IlcpDcsaLcosL.s.hIpul+KpGMLHQLANDhcc-laWu-.......
//