#=GF ID   CadC_C1
#=GF AC   PF18500.5
#=GF DE   CadC C-terminal domain 1
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF01548
#=GF GA   25.00 25.00;
#=GF TC   28.00 101.40;
#=GF NC   24.00 22.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0342
#=GF RN   [1]
#=GF RM   21308846
#=GF RT   Crystal structure of the sensory domain of Escherichia coli
#=GF RT   CadC, a member of the ToxR-like protein family.
#=GF RA   Eichinger A, Haneburger I, Koller C, Jung K, Skerra A;
#=GF RL   Protein Sci. 2011;20:656-669.
#=GF DR   INTERPRO; IPR040970;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   CadC is an integral membrane protein of 512 amino acids
#=GF CC   comprising an N-terminal cytoplasmic DNA-binding domain, a
#=GF CC   transmembrane helix, and a C-terminal periplasmic domain. CadC
#=GF CC   belongs to the ToxR-like regulators that encompass biochemically
#=GF CC   non-modified one-component systems with similar gross topology,
#=GF CC   including several low pH-induced transcription regulators.
#=GF CC   Structural analysis of the C-terminal periplasmic domain
#=GF CC   indicates that it resembles the sensory domain of a
#=GF CC   (pH-activated) ToxR-like regulator. Furthermore, it is composed
#=GF CC   of two subdomains with a cavity at their interface that is
#=GF CC   suited to accommodate cadaverine, the feedback inhibitor of the
#=GF CC   Cad system. This is the N-terminal subdomain of the C-terminal
#=GF CC   periplasmic domain. It is composed of five-stranded beta-sheets
#=GF CC   [1].
#=GF SQ   36
#=GS A0A4Z0L4F0_SALET/11-144   AC A0A4Z0L4F0.1
#=GS A0A447M0D8_SALBN/191-324  AC A0A447M0D8.1
#=GS R8AMB9_PLESH/180-312      AC R8AMB9.1
#=GS A0A085UBM3_YERRU/194-327  AC A0A085UBM3.1
#=GS A0A085A7L3_9ENTR/189-322  AC A0A085A7L3.1
#=GS A9MHI0_SALAR/191-324      AC A9MHI0.1
#=GS A0A378DKE7_KLEPR/100-233  AC A0A378DKE7.1
#=GS C5B7S6_EDWI9/226-359      AC C5B7S6.1
#=GS CADC_ECOLI/190-324        AC P23890.1
#=GS Q8ZN35_SALTY/193-326      AC Q8ZN35.1
#=GS A0A378BWH9_KLEPO/217-350  AC A0A378BWH9.1
#=GS A0A0H3GJJ5_KLEPH/201-334  AC A0A0H3GJJ5.1
#=GS E3G7X4_ENTLS/191-324      AC E3G7X4.1
#=GS H5V4G9_ATLHE/185-318      AC H5V4G9.1
#=GS A0A086GAU5_9GAMM/198-331  AC A0A086GAU5.1
#=GS A0A509CKU5_9ENTR/27-160   AC A0A509CKU5.1
#=GS A0A370QPW6_9GAMM/191-324  AC A0A370QPW6.1
#=GS A0A0J5P875_PLUGE/183-316  AC A0A0J5P875.1
#=GS A0A5R9LPE4_9ENTR/182-315  AC A0A5R9LPE4.1
#=GS A0A090UZF6_PSEVU/177-310  AC A0A090UZF6.1
#=GS A0A859RNC1_9ENTR/189-322  AC A0A859RNC1.1
#=GS I2BCI7_SHIBC/193-326      AC I2BCI7.1
#=GS D4E2F2_SEROD/194-327      AC D4E2F2.1
#=GS W1DGB6_KLEPN/18-85        AC W1DGB6.1
#=GS A0A2X4TKM1_SALER/191-324  AC A0A2X4TKM1.1
#=GS A6T5S7_KLEP7/201-334      AC A6T5S7.1
#=GS Q8XDS2_ECO57/190-324      AC Q8XDS2.1
#=GS W1EFW1_KLEPN/24-157       AC W1EFW1.1
#=GS W1HSW6_KLEPN/30-163       AC W1HSW6.1
#=GS A0A1W6B7Z8_9GAMM/194-327  AC A0A1W6B7Z8.1
#=GS J2XBX7_KLEPN/201-334      AC J2XBX7.1
#=GS E3G897_ENTLS/190-323      AC E3G897.1
#=GS A0A1I4VXD0_9GAMM/188-321  AC A0A1I4VXD0.1
#=GS A0A097R5I1_HAFAL/212-345  AC A0A097R5I1.1
#=GS W1DIP7_KLEPN/1-77         AC W1DIP7.1
#=GS A0A0F7H7F8_SERFO/195-328  AC A0A0F7H7F8.1
A0A4Z0L4F0_SALET/11-144              ...t-RLLLNPRDIDVR.FEGGNSCNNWVS..QESYAIGLGGLITDLLNTYSTFMVHDKTNYRVNEPSSSGKTLTIQFVNQRHYRAQQCFMSVVLIDNADGSTMLDKRYFVTNTNQLSIQDDLFNSLSFVLTQPWPNRMRE...
A0A447M0D8_SALBN/191-324             ...t-RLLLNPRDIDVR.FEGGNSCNNWVS..QESYAIGLGGLITDLLNTYSTFMVHDKTNYRVNEPSSSGKTLTIQFVNQRHYRAQQCFMSVVLIDNADGSTMLDKRYFVTNTNQLSIQDDLFNSLSFVLTQPWPDRMRE...
R8AMB9_PLESH/180-312                 ..sp--VLMDPNAVSIQwVANPNS--VCAN..TQGPISSVNELLAQALNNYSPYNAHDMTNYSGRSLPTAGKTLYTQFENQQHHRVSQCFLSVSLVNNATRKVLMSKRYIITETNLLTVQVDVLNHVFAVLGLQPPQT---lit
A0A085UBM3_YERRU/194-327             ...m-PMLMNPRDIDIR.IQGGNSCSHWTS..QLSYVAGLSEVVTDSLNTYSTFLVHDQTNYNYTGPSSSGKSLTIEFVNQRHYRAQQCFLSVRLVDNADSSIMLDKRYFVTADNQLKIQEDFLSSLSIALKQPWPAALQQ...
A0A085A7L3_9ENTR/189-322             ...t-RLLLNPRDIDIR.LENGSSCNNWMS..QRSYAVGLGSLVTTSLNTYSTFMVHDKTNYNVNEPSSSGKTLSIEFVNQRHYRAQQCFMSVQLVDNADGSSMLDKRYFITNGNQLTIQNDLMNSLSEALKQPWPEKMQE...
A9MHI0_SALAR/191-324                 ...t-RLLLNPRDIDVR.FEGGNSCNNWLS..QESYAIGLGGLITDLLNTYSTFMVHDKTNYRVNEPSSSGKTLTIQFVNQRHYRAQQCFMSVVLIDNADGSTMLDKRYFVTNTNQLSIQDDLFNSLSFVLTQPWPDRMRE...
A0A378DKE7_KLEPR/100-233             ...a-RLLLNPRDIDIH.LVNGNSCANWSS..QHSYAVGLASLITTSLNTFSTFMVHDKTDYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVQLVDNADSSTMLDKRYFVTNDNQLTIQNDLMNSLSDALAQPWPARMQ-a..
C5B7S6_EDWI9/226-359                 ...h-PMLLNPRDIDIR.IQGGNRCSNWTN..QLSYVIGLSEDLAQGLNTYSTFLVHDQTNYNYGGKSSSGKSLYIEFVNQRHYRAQQCFLSVRLVDNADNLVMLEKRYFITPDNLLSVQKDFINSIFTVLKVSMPPSL--dk.
CADC_ECOLI/190-324                   ...s-RILLNPRDIDIN.MVN-KSCNSWSSpyQLSYAIGVGDLVATSLNTFSTFMVHDKINYNIDEPSSSGKTLSIAFVNQRQYRAQQCFMSIKLVDNADGSTMLDKRYVITNGNQLAIQNDLLESLSKALNQPWPQRMQE...
Q8ZN35_SALTY/193-326                 ...t-RLLLNPRDIDVR.FEGGNSCNNWVS..QESYAIGLGGLITDLLNTYSTFMVHDKTNYRVNEPSSSGKTLTIQFVNQRHYRAQQCFMSVVLIDNADGSTMLDKRYFVTNTNQLSIQDDLFNSLSFVLTQPWPNRMRE...
A0A378BWH9_KLEPO/217-350             ...a-RLLLNPRDIDIH.LVNGNSCANWSS..QHSYAVGLASLITTSLNTFSTFMVHDKTDYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVQLVDNADSSTMLDKRYFVTNDNQLTIQNDLMNSLSDALAQPWPARMQ-a..
A0A0H3GJJ5_KLEPH/201-334             ...a-RLLLNPRDIDIH.LVNGNSCANWSS..QHSYAVGLASLITTSLNTFSTFMVHDKTDYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVQLVDNADSSTMLDKRYFVTNDNQLTIQNDLMNSLSDALAQPWPARMQ-a..
E3G7X4_ENTLS/191-324                 ...t-RLLLNPRDIDIR.LMNGNSCNNWAS..QRSYAVGLGSLITTSLNTFSTFMVHDKTNYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVQLVDNADGSVMLDKRYFITNDNQLSIQNDLMNSLSESLTQPWPERMQ-a..
H5V4G9_ATLHE/185-318                 ...r-QLMLNPRDIDIR.VENGSACSNWAS..QKAYVAGVSNLMTTLLNTFSTFFVHDKTNYPFNDLSSSGKTLTVSFVNKRHYRAQQCFMSVRLFDNAQQAMMFEKRYFITNDNQLIIVADLLSTLSGALKQTWPAQMTQ...
A0A086GAU5_9GAMM/198-331             ..mp--VLLNPRDIDIR.IQGGESCSNWMP..QLSYVVGVSELITDSLNTYSTFLVHDQTNYNYSGPSNSGKSLYIEFVNQRHYRAQQCFLSVRLVDNADSSIMLDKRYFITADNQLKIQTDFLASLSAALKQPWPPQLE-q..
A0A509CKU5_9ENTR/27-160              ...t-RLLLNPRDIDVR.FEGGNSCNNWVS..QESYAIGLGGLITDLLNTYSTFMVHDKTNYRVNEPSSSGKTLTIQFVNQRHYRAQQCFMSVVLIDNADGSTMLDKRYFVTNTNQLSIQDDLFNSLSFVLTQPWPGRMRE...
A0A370QPW6_9GAMM/191-324             ...a-PMLLNPRDIDIR.IQGGNSCSNWTN..QLSYVVGISEQLTQGLNTYSTFLVHDQTNYNYGGPSSSGKSLFIEFVNQRHYRAQQCFLSVRLIDNADASVMLEKRYFITADNLLTVQQDFVNSVFQVLKITPPPQL--ld.
A0A0J5P875_PLUGE/183-316             ...t-RLLLNPRDIDIH.LVNGNSCNNWAS..QHSYAVGLGSLITTSLNTFSTFMVHDKTDYNVNEPSTSGKTLTIEFVNQRHYRAQQCFMSVKLIDNADGSVMLDKRYFVTSDNQISIQNDLMNSLSQSLMQPWPDAMQ-a..
A0A5R9LPE4_9ENTR/182-315             ...a-RLLLNPRDIDIH.LLTGNTCNNWSS..QHAYAIGLGSLITTSLNTFSTFMVHDKTNYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVKVVDNADGSTMMDKRYFVTSDNQLSIQNDLLSSLSEVLKQPWPARMQE...
A0A090UZF6_PSEVU/177-310             ...a-RLLLNPRDIDIH.LVDSSGCTNRSS..QHAYAVGLGSLITTTLNTFSTFMVHDKTNYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSIKLVDNADGSTMLDKRYFVTSDNQLSIQNDLMNSLSEALTQPWPERLQ-t..
A0A859RNC1_9ENTR/189-322             ...t-RLLLNPRDVDIH.LLSGNTCNNWSS..QHSYAIGLGSLITTSLNTFSTFMVHDKTNYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVKVVDNADGSTMMDKRYFVTSDNQLSIQNDLLSSLSEALKQPWPARMQE...
I2BCI7_SHIBC/193-326                 ....DKLLLNPRDIDIR.LVNGNSCSNWSS..QRSYVVGISELISSSLNTWSTFLVHDKTDFNINNPSTSGKSLNIEFVNQRHYRSQQCFMSVKLVDNADRSVMLDKRYFITRDNLVEIQNDLLNNLSVVLQQPWPDVMKE...
D4E2F2_SEROD/194-327                 ...m-PMLLNPRDIDIR.IQGGNSCSNWMP..QLSYVVGLSELIADSLNTYSTFLVHDQTNYNYGGPSSSGKSLTIEFVNQRHYRAQQCFLSVKLVDNADSAIMLDKRYFITTDNQLKIQADLLNSMSVALKQPWPPQL--lk.
W1DGB6_KLEPN/18-85                   ...a-RLLLNPRDIDIH.LVNGNSCANWSS..QHSYAVGLASLITTSLNTFSTFMVHDKTDYNINEPSSSGKN--------------------------------------------------------------------ad.
A0A2X4TKM1_SALER/191-324             ...t-RLLLNPRDIDVR.FEGGNSCNNWLS..QESYAIGLGGLITDLLNTYSTFMVHDKTNYRVNEPSSSGKTLTIQFVNQRHYRAQQCFMSVVLIDNADGSTMLDKRYFVTNTNQLSIQDDLFNSLSFVLTQPWPDRMRE...
A6T5S7_KLEP7/201-334                 ...a-RLLLNPRDIDIH.LVNGNSCANWSS..QHSYAVGLASLITTSLNTFSTFMVHDKTDYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVQLVDNADSSTMLDKRYFVTNDNQLTIQNDLMNSLSDALAQPWPARMQ-a..
Q8XDS2_ECO57/190-324                 ...s-RILLNPRDIDIN.MVN-KSCNSWSSpyQLSYAIGVGDLVATSLNTFSTFMVHDKINYNIDEPSSSGKTLSIAFVNQRQYRAQQCFMSIKLVDNADGSTMLDKRYVITNGNQLAIQNDLLESLSKALNQPWPQRMQE...
W1EFW1_KLEPN/24-157                  ...a-RLLLNPRDIDIH.LVNGNSCANWSS..QHSYAVGLASLITTSLNTFSTFMVHDKTDYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVQLVDNADSSTMLDKRYFVTNDNQLTIQNDLMNSLSDALAQPWPARMQ-a..
W1HSW6_KLEPN/30-163                  ...a-RLLLNPRDIDIH.LVNGNSCANWSS..QHSYAVGLASLITTSLNTFSTFMVHDKTDYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVQLVDNADSSTMLDKRYFVTNDNQLTIQNDLMNSLSDALAQPWPARMQ-a..
A0A1W6B7Z8_9GAMM/194-327             .skg---IINPRDIDIQ.FSGRPTCTNWTR..QSTYMMGIADQITNLFNTYSTYMVHNQTDYRYRGPTSAGKILTIEFVNQRHYREQQCFMAVRLVDNADSSVMLDRRYFITHDNQLAIQHDLLKSLSQALQQPWSEKMQ-r..
J2XBX7_KLEPN/201-334                 ...a-RLLLNPRDIDIH.LVNGNSCANWSS..QHSYAVGLASLITTSLNTFSTFMVHDKTDYNINEPSSSGKTLTIEFVNQRHYRAQQCFMSVQLVDNADSSTMLDKRYFVTNDNQLTIQNDLMNSLSDALAQPWPARMQ-a..
E3G897_ENTLS/190-323                 ...t-RLLLNPRDIDIR.LENGNSCNNWMS..QRSYAVGLGNLVTTLLNTHSTFMVHDKTDYNFNEPSSSGKTLTIEFVNQRHYRAQQCFMSVQLVNNADGSSMLDKRYFITNGNQLVIQNDLMDSLSEALEQPWSEKMHE...
A0A1I4VXD0_9GAMM/188-321             ..tl--LMLNPRDIDVR.LLNGDSCNEHSL..QYPYAVGIGDLITTSLNTYSTFMVHDRTNYNVNEPDSSGKTLTIEFVNQRHYRSQQCFMSVKLIDNGDSSVMLDKRYFITNDNQLSILKDLLNNLSTALAQPWPTEMQ-k..
A0A097R5I1_HAFAL/212-345             ...a-PMLLNPRDIDIR.IQGGNSCTNWTN..QLSYVVGLSEMLAQGLNTHSTFLVHDQTNYNYGGPSSSGKSMFIEFVNQRHYRAQQCFLSVRLIDNADSSVMLEKRYFITTDNLLTVQKDFIDSMFQTLKVVQPASMVQ...
W1DIP7_KLEPN/1-77                    mnqa-------------.------------..------------------------------------VPAKTLTIEFVNQRHYRAQQCFMSVQLVDNADSSTMLDKRYFVTNDNQLTIQNDLMNSLSDALAQPWPARMQ-a..
A0A0F7H7F8_SERFO/195-328             ..mp--VLLNPRDIDIR.IQGGNSCSNWTP..QLSYVVGVSELVTDALNTYSTFLVHDQTNYNFAGPSSSGKSLYIEFVNQRHYRAQQCFLSVRLVDNADSSIMLDKRYFITTDNQLKIQQDFLTSLSAALKQPWPQQL--al.
#=GC seq_cons                        ...s.RLLLNPRDIDI+.l.sGNSCsNWsS..QcSYAlGLusLITsuLNTaSTFMVHDKTNYNlNEPSSSGKTLTIEFVNQRHYRAQQCFMSVpLVDNADuSsMLDKRYFlTsDNQLoIQsDLhNSLSpuLpQPWPs+Mp....
//