#=GF ID Caf4
#=GF AC PF11615.12
#=GF DE CCR4-associated factor 4
#=GF PI DUF3249;
#=GF AU Pollington J;0000-0002-8158-8998
#=GF SE pdb_2pqr
#=GF GA 21.00 21.00;
#=GF TC 21.10 21.40;
#=GF NC 20.80 20.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11113136
#=GF RT Characterization of CAF4 and CAF16 reveals a functional
#=GF RT connection between the CCR4-NOT complex and a subset of SRB
#=GF RT proteins of the RNA polymerase II holoenzyme.
#=GF RA Liu HY, Chiang YC, Pan J, Chen J, Salvadore C, Audino DC,
#=GF RA Badarinarayana V, Palaniswamy V, Anderson B, Denis CL;
#=GF RL J Biol Chem. 2001;276:7541-7548.
#=GF RN [2]
#=GF RM 16009724
#=GF RT The WD40 protein Caf4p is a component of the mitochondrial
#=GF RT fission machinery and recruits Dnm1p to mitochondria.
#=GF RA Griffin EE, Graumann J, Chan DC;
#=GF RL J Cell Biol. 2005;170:237-248.
#=GF RN [3]
#=GF RM 16835275
#=GF RT Fis1p and Caf4p, but not Mdv1p, determine the polar localization
#=GF RT of Dnm1p clusters on the mitochondrial surface.
#=GF RA Schauss AC, Bewersdorf J, Jakobs S;
#=GF RL J Cell Sci. 2006;119:3098-3106.
#=GF DR INTERPRO; IPR021653;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Caf4 is a WD40 repeats containing protein involved in
#=GF CC mitochondrial fission. It displays physical interactions with
#=GF CC CCR4-NOT complex [1]. It has a paralogue, Mdv1. Both Caf4 and
#=GF CC Mdv1 act as adapter proteins, binding to Fis1 on the
#=GF CC mitochondrial outer membrane and recruiting the dynamin-like
#=GF CC GTPase Dnm1 to form mitochondrial fission complexes [2].
#=GF CC However, Fis1 and Caf4, but not Mdv1, determine the polar
#=GF CC localization of Dnm1 clusters on the mitochondrial surface [3].
#=GF SQ 6
#=GS A0A835H9D9_9MAGN/210-264 AC A0A835H9D9.1
#=GS J8TXM6_SACK1/65-124 AC J8TXM6.1
#=GS A0A1E3P115_WICAA/83-140 AC A0A1E3P115.1
#=GS CAF4_YEAST/65-124 AC P36130.3
#=GS G0V7S1_NAUCC/83-158 AC G0V7S1.1
#=GS A0A4C2E2F8_9SACH/27-72 AC A0A4C2E2F8.1
A0A835H9D9_9MAGN/210-264 .......QRTTLDQGSCPLAFANRSYTIKLAAHIENEAH.PYPID.............S...vARHNLASVLD------------hhgssr..........
J8TXM6_SACK1/65-124 .......QRDQMGRSSFQNNFADSATTFKILAHLDNERY.PLPID.............A....AKEQLPSLFEGFNATISTVKQK................
A0A1E3P115_WICAA/83-140 ryatste--------YFKNAFSSSKTAYKILTHIPDELL.E-EIP.............E....EKPQAFSLFQGFNATLPEV---dee.............
CAF4_YEAST/65-124 .......QKGQVGIFSFQNNYADSATTFRILAHLDEQRY.PLPNG.............A....AEKNLPSLFEGFKATVSIIQQR................
G0V7S1_NAUCC/83-158 ....akd-----GKSYFNNRYTDLRTSFKIMTHLNDEILnDIPSDvskstdngrktikAaaenATDQGPSLFQGFEASIPIIDQ-l...............
A0A4C2E2F8_9SACH/27-72 ......l-RSTNGKTFFQNKFADSKTSFKVLSYLSDD--.-----.............-....----------------------qlsdipnefdgtnlsl
#=GC seq_cons ........+sp.Gps.FpNsFADSpToFKILuHLs-Ehh.shP.s.............u....AccphsSLFpGFpAols.l...................
//
