#=GF ID CaiF_GrlA
#=GF AC PF07180.15
#=GF DE CaiF/GrlA transcriptional regulator
#=GF PI DUF1401;
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_16789 (release 10.0)
#=GF GA 25.00 25.00;
#=GF TC 26.50 26.10;
#=GF NC 23.60 19.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF CL CL0123
#=GF RN [1]
#=GF RM 8631699
#=GF RT Identification and characterization of the caiF gene encoding a
#=GF RT potential transcriptional activator of carnitine metabolism in
#=GF RT Escherichia coli.
#=GF RA Eichler K, Buchet A, Lemke R, Kleber HP, Mandrand-Berthelot MA;
#=GF RL J Bacteriol. 1996;178:1248-1257.
#=GF RN [2]
#=GF RM 24092262
#=GF RT Structure of GrlR-GrlA complex that prevents GrlA activation of
#=GF RT virulence genes.
#=GF RA Padavannil A, Jobichen C, Mills E, Velazquez-Campoy A, Li M,
#=GF RA Leung KY, Mok YK, Rosenshine I, Sivaraman J;
#=GF RL Nat Commun. 2013;4:2546.
#=GF DR INTERPRO; IPR020357;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This is a family of transcriptional regulators. CaiF is involved
#=GF CC in carnitine metabolism [1]. GrlA is encoded within the LEE type
#=GF CC III secretion system in the enteropathogenic E. coli O157:H
#=GF CC [2]. GrlR interacts with GrlA at its Helix-Turn-Helix (HTH)
#=GF CC motif, preventing GrlA from binding to its target promoter DNA.
#=GF SQ 38
#=GS T0QFK2_PHOTE/27-156 AC T0QFK2.1
#=GS A0A2I0FWA3_9GAMM/16-143 AC A0A2I0FWA3.1
#=GS A0A859PWL2_9ENTR/5-110 AC A0A859PWL2.1
#=GS D2TKG4_CITRI/1-135 AC D2TKG4.1
#=GS D2TGM1_CITRI/3-77 AC D2TGM1.1
#=GS A0A381H9C6_CITKO/2-81 AC A0A381H9C6.1
#=GS CAIF_ECOLI/2-110 AC P0AE58.1
#=GS A0A2C6DV90_9GAMM/2-105 AC A0A2C6DV90.1
#=GS A0A656YFF4_SALNE/19-124 AC A0A656YFF4.1
#=GS L0M8W9_ENTBF/2-101 AC L0M8W9.1
#=GS Q7DB62_ECO57/1-137 AC Q7DB62.1
#=GS B4EY28_PROMH/3-73 AC B4EY28.1
#=GS A8ALR9_CITK8/2-81 AC A8ALR9.1
#=GS A0A0Q4MGM1_9GAMM/19-114 AC A0A0Q4MGM1.1
#=GS A0A3S4I8L6_SALBN/10-156 AC A0A3S4I8L6.1
#=GS A0A1B7JPY6_9GAMM/2-92 AC A0A1B7JPY6.1
#=GS A0A085HGD4_9GAMM/1-120 AC A0A085HGD4.1
#=GS Q7N9P5_PHOLL/27-164 AC Q7N9P5.1
#=GS Q7CR90_SALTY/1-69 AC Q7CR90.1
#=GS A0A370R3E7_9GAMM/1-118 AC A0A370R3E7.1
#=GS A0A097R6J8_HAFAL/1-89 AC A0A097R6J8.1
#=GS CAIF_SHIFL/2-110 AC P0AE59.1
#=GS A0A6I6EUP1_9GAMM/4-143 AC A0A6I6EUP1.1
#=GS A0A4Z0PA80_SALET/1-120 AC A0A4Z0PA80.1
#=GS C0ATT7_9GAMM/1-73 AC C0ATT7.1
#=GS A0A4P7J4F7_9ENTR/1-84 AC A0A4P7J4F7.1
#=GS A0A4Z0L4B2_SALET/19-164 AC A0A4Z0L4B2.1
#=GS A0A2I8Q8R5_9ENTR/1-81 AC A0A2I8Q8R5.1
#=GS Q32K63_SHIDS/27-138 AC Q32K63.1
#=GS E3G9M8_ENTLS/1-105 AC E3G9M8.1
#=GS A0A2X4TLW8_SALER/1-98 AC A0A2X4TLW8.1
#=GS C5B8S0_EDWI9/3-88 AC C5B8S0.1
#=GS I2BCX8_SHIBC/4-94 AC I2BCX8.1
#=GS Q8XA37_ECO57/2-110 AC Q8XA37.2
#=GS E3GCC9_ENTLS/15-151 AC E3GCC9.1
#=GS A9MR34_SALAR/1-98 AC A9MR34.1
#=GS A0A509BKG6_9ENTR/28-119 AC A0A509BKG6.1
#=GS A0A3S4EZH2_SALBN/1-116 AC A0A3S4EZH2.1
T0QFK2_PHOTE/27-156 ...............t-GKQSNHGDFRLPACLSHLNDTPLYMAVAYWGLLKGRGFTKREISQVFRVTERRATDVMNYIYNERRDVI-ACEKV.FFREKQGSRR.LMLIVTAVVEPM..PQKGQ..APV--------------------------------------------tktvkstrsrtssqanhmrtwflqr..................................
A0A2I0FWA3_9GAMM/16-143 ..............iv---QKNHAGCVVPASVKKWAHLPMYQLIALWCLQQKRWVDRDEIADAFRIDKRRASFLMSYILGRPARIHCQAREI.PRVDSHYSLH.TLLVENVILDEV..PAPARtpIDTTP------KCRRVGNGAA--------------------------edwqwllrr..................................................
A0A859PWL2_9ENTR/5-110 ...............s-GKQSNHGSFIVPEELGDETCSTLHEYVARWLLITRKYACCDDIANAFGISRRQASNIIYNIHRKHADM-------.----------.------------..-----..-----------------------------------------------yllsmkrikegkgnvvkiwlkiesinpvkknkkktks......................
D2TKG4_CITRI/1-135 ..............me----SKNSDYVIPDSVKNYNGEPLYILVSLWCKLQEKWISRNDIAEAFGINLRRASFIITYISRRKEKISFRVRYV.SYGNLHYKRL.EIFIYNVNLEAA..PTESH..VSTGP----KRKTLRVGNGIVGQSS-IWNEM--------IMRRKKE-s..........................................................
D2TGM1_CITRI/3-77 ...........eervd---------------------KPLYLLIADWVMAEKRWVSAKEIAKQFNMDHCKASNTVSYILAEVAEIH--CETK.TIPN------.------------..-----..-----------------------------------------------qlegrgcqcqrlv..............................................
A0A381H9C6_CITKO/2-81 ..............se-----------------KYVEKPLYLLIADWVMAENRWVSAKEIAKQFNMDYCKAINTVSYILSEVGEIECETR--.T---------.------------..-----..-----------------------------------------------ipnqlegrgcqcqrlvrikr.......................................
CAIF_ECOLI/2-110 .............ceg------------------YVEKPLYLLIAEWMMAENRWVIAREISIHFDIEHSKAVNTLTYILSEVTEISCEVKM-.----------.------------..-----..-----------------------------------------------ipnklegrgcqcqrlvkvvdideqiyarlrnnsreklvgvrktpripav..........
A0A2C6DV90_9GAMM/2-105 .............sel------------------FDREPLYLSIARWSMQQQRWVNANEIAEQFDLSRKRVINIVSYMIAEVTEIACVTK--.T---------.------------..-----..-----------------------------------------------ipndlagsgcqcqrlirvnhidesidvrvknavnktkppqqvee...............
A0A656YFF4_SALNE/19-124 ................YPGQTNHDACFIPASVRQYAGEPLYIIVAHWCLLQQNWVQRNQIAEAFHITARRASYLIAYLRSKTSRVVSICRHQ.TLPN-KARRY.EIYVIRVLDSPT..PSTRR..EKAG-------------------------------------------...........................................................
L0M8W9_ENTBF/2-101 ..............se-----------------QCVGKPLYLLIAEWIMAEDRWVTAREISIHFDIEHSKAINTLSYILSEVGEISCEVKM-.----------.------------..-----..-----------------------------------------------ipnklegrgcqcqrlvkvvaidsqlyervnhhvrekmagv...................
Q7DB62_ECO57/1-137 ................MESKNKNGDYVIPDSVKNYDGEPLYILVSLWCKLQEKWISRNDIAEAFGINLRRASFIITYISRRKEKISFRVRYV.SYGNLHYKRL.EIFIYDVNLEAV..PIESP..GTTGP----KRKTYRVGNGIVGQSN-IWNEM--------IMRRKKE-s..........................................................
B4EY28_PROMH/3-73 ...........eedin---------------------KPLYLLIADWVQEQQRWVSAKEIAKNFDIPQCNAINIVSYILSDVKEIEC--DTK.S---------.------------..-----..-----------------------------------------------vpnqlegrgcqc...............................................
A8ALR9_CITK8/2-81 ..............se-----------------KYVEKPLYLLIADWVMAENRWVSAKEIAKQFNMDYCKAINTVSYILSEVGEIECETR--.T---------.------------..-----..-----------------------------------------------ipnqlegrgcqcqrlvrikr.......................................
A0A0Q4MGM1_9GAMM/19-114 .............vvq---QRNHEGSRIPAELARYAGQPLYMLIALWCWKQKRWVDHKTISSVFEITERRASFQVSYLTQKSDRIQLQVRKV.KSEGAQRISR.EIWVQRVK----..-----..-----------------------------------------------wr.........................................................
A0A3S4I8L6_SALBN/10-156 ...............k-PNQSNHENTIIPESVSQYSKQPLYIIIALWCQQQNRWINRNDIAHAFSMPVRRASFQLSYMTRRPKHIHFRSRQQiSSGEGKQHLYnEIWVENVIIESQdqSIERA..PPKGERGVMGAYRSRVGNGMSGGAN-IWDTLITMRRAKK--------eg.........................................................
A0A1B7JPY6_9GAMM/2-92 ..............cg-----------------QYINEPLYLTIANWVLKQDRWTTAREISNNFDIPHPNAVNIVSYILSDVAEIQCEVKM-.----------.------------..-----..-----------------------------------------------ipnklsgrgcqcqrlikvtridnqlysrlrg............................
A0A085HGD4_9GAMM/1-120 ..............my----------------REYVQEPLYLSVARWVMQQKRWVSATEIAEHFNLTTCKAINTVSYILSEVSEIVCK--TK.SVPN------.------------..-----..-----------------------------------------------qlegrgcqcqrliqvdsiddlissriknavnaegesdsderleqgirvppselnqe...
Q7N9P5_PHOLL/27-164 ...............t-GKQSNHGDFRLPACLSHLKDTPLYMAVAYWGLLKGSGFTKSEISQVFRVTERRATDVMNYIYNERRDV-IACEKV.FFREKQGSRR.QMLIVTAVVEPM..PQKGQ..ASVTKTVKSTR------------------------------------srtlsqanhmciwrtwflqracgpf..................................
Q7CR90_SALTY/1-69 .............mce-----------------KYVERPLYLLIADWMMAENRWITAREISRQFDIEHCKAINTLSYILSEVGEIVCEVKM-.----------.------------..-----..-----------------------------------------------ipnqiagr...................................................
A0A370R3E7_9GAMM/1-118 ..............ms----------------RNFDREPLYLCVARWVMQQKTWVCAQSIAEQFGLPLSKAVNTVSYILAEVNEITCS--TK.TVPN------.------------..-----..-----------------------------------------------qlagrgcqcqrllrvehiddsiearllnavniesiptslsdrittaippgklnr.....
A0A097R6J8_HAFAL/1-89 ..............mc----------------REYVPEPLYLSVARWAMQQQRWISSREIAEQFDLTPCKAINLVSYILSAVDEIDC--QTK.TVPN------.------------..-----..-----------------------------------------------qlegrgcqcqrmiqvdhiddhiaer..................................
CAIF_SHIFL/2-110 .............ceg------------------YVEKPLYLLIAEWMMAENRWVIAREISIHFDIEHSKAVNTLTYILSEVTEISCEVKM-.----------.------------..-----..-----------------------------------------------ipnklegrgcqcqrlvkvvdideqiyarlrnnsreklvgvrktpripav..........
A0A6I6EUP1_9GAMM/4-143 ilayvdekkvrlakvv--AQSNHDGGCVPEELKDYADRPLYLLIALWCYRQRTWIDRKQISAAFAITERRASFQISYIIRKNNIVRCQTRKI.KAPGSRHLCH.EILVENVLLTPE..DVKKP..SQSHT--NCKR------------------------------------rsrdnicqndmrwl.............................................
A0A4Z0PA80_SALET/1-120 .............mce-----------------KYVERPLYLLIADWMMAESRWITAREISRQFDIEHCKAINTLSYILSEVGEIVCEVKM-.----------.------------..-----..-----------------------------------------------ipnqiagrgcqsqrlvkvvsidsqryrrlndnlqerkvsvakaprlsavpptelnreqk
C0ATT7_9GAMM/1-73 ..............mc----------------EEYMNKPLYLSIADWVQEQERWVSAKEIAKKFDIPQCNAINIVSYILSDVKEIEC--ETK.SVP-------.------------..-----..-----------------------------------------------nqlegrgcqc.................................................
A0A4P7J4F7_9ENTR/1-84 .............mce-----------------EYVERPLYLLISDWIMAEDRWVTAKEISRQFDIEHCKAINTLSYILSEVSEIVCEVKM-.----------.------------..-----..-----------------------------------------------ipnqlagrgcqcqrlvkvvsidp....................................
A0A4Z0L4B2_SALET/19-164 ................YPGQTNHDACFIPVSVRQYAGEPLYIIVAHWCLLQQNWVQRNQIAEAVHITARRASNLIAYLRSKTSRVVSICRHQ.TLPN-KARRY.EIYVIRVLDSPT..PSTRR..EKAGPPPVSKR---RVGNGDRSMANELWSRLGSHSNAGKILKKKEDE...........................................................
A0A2I8Q8R5_9ENTR/1-81 ..............ms----------------KEYVEKPLYLLIADWVMAENRWVSAKEIARHFDMDHCKAINTVSYILSEVEEISCE--TK.TIPN------.------------..-----..-----------------------------------------------qlqgrgcqcqrlvrvkn..........................................
Q32K63_SHIDS/27-138 ....llicetgvrmce-----------------GYVEKPLYLLIAEWMMAENRWVIAREISIHFDIEHSKAVNTLTYILSEVTKISCEVKM-.----------.------------..-----..-----------------------------------------------ipnklegrgcqcqrlvkvvdideqiyarlrnnsreklvgvrk.................
E3G9M8_ENTLS/1-105 .............mce-----------------EYVDKPLYLLIADWVMAQNRWVSAKEIAGQFDIPHCKAINTVSYILAEVGEIE--CETK.TI--------.------------..-----..-----------------------------------------------pnqlegrgcqcqrlvrvrkiskllyerlkspasvkstlcanps................
A0A2X4TLW8_SALER/1-98 ..............ms----------------KEYVEKPLYLLIADWVMAENRWVSAKEIAKQFNMDHCKAINTVSYILSEVGEIN--CETK.TIPN------.------------..-----..-----------------------------------------------qlegrgcqcqrlvriksidsqlyarignsarekm.........................
C5B8S0_EDWI9/3-88 ............gnmr----------------REYAQEPLYLSVARWVMQQQRWVSAREIAQQFDLSPCKAINTVSYILSGVEEITCQ--TK.TVPN------.------------..-----..-----------------------------------------------qlegrgcqcqrliqvthide.......................................
I2BCX8_SHIBC/4-94 ............tnvv---------------------KPLYFQIADWMMAQNRWVSAGEIARQFGIEHCKAINTVSYILGEVAEIECETR--.T---------.------------..-----..-----------------------------------------------ipnqlegrgcqcqrqvrvrnidaglyarfkkqe..........................
Q8XA37_ECO57/2-110 .............ceg------------------YVEKPLYLLIAEWMMAENRWVIAREISIHFDIEHSKAVNTLTYILSEVTEISCEVKM-.----------.------------..-----..-----------------------------------------------ipnklegrgcqcqrlvkvvdideqiyarlrnnsreklvgvrktpripav..........
E3GCC9_ENTLS/15-151 ...............h-PSQAGYDACYIPESVRQYRGEPLYILVAWWCLQQHDWVNRNQISEAFRVPVQRASYLMAYLRNKTRRVIVESRQM.LLAN-NVYRY.EIQVTRVMLPGS..R-KKR..LPGEKRRLTR---RRIGNADTTQATLIWNNL----------------rkgnpspv...................................................
A9MR34_SALAR/1-98 ..............ms----------------KEYVEKPLYLLIADWVMAENRWVSAKEIAKQFNMDHCKAINTVSYILSEVGEIN--CETK.TIPN------.------------..-----..-----------------------------------------------qlegrgcqcqrlvriksidsqlyarignsarekm.........................
A0A509BKG6_9ENTR/28-119 ...............k-GSQKNHGEYRLPADMQPWANEPLYLIIARWCLQQNRWINRNDVAAAFYLTERRASLQLAYINQKKNRIACRT---.----------.------------..-----..-----------------------------------------------vsmfptikdtttmrygsit........................................
A0A3S4EZH2_SALBN/1-116 .............mce-----------------KYVERPLYLLIADWMMAENRWITAREISRQFDIEHCKAINTLSYILSEVGEIVCEVKM-.----------.------------..-----..-----------------------------------------------ipnqiagrgcqcqrlvkvvsidsqlyrrlnhnlqerkvsvaktprlsavppnrak....
#=GC seq_cons ...............p.................pYspcPLYLLIAcWshtppRWVoA+EIAcpFclscs+AlNplSYILu-VsEIpCps+h...................................................................................pthtspspph.ph.ph.........................................
//
