#=GF ID   Cas_Csa4
#=GF AC   PF09703.14
#=GF DE   CRISPR-associated protein (Cas_Csa4)
#=GF AU   TIGRFAMs;
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   TIGRFAMs
#=GF GA   25.00 25.00;
#=GF TC   27.10 105.80;
#=GF NC   24.40 24.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR010184;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   CRISPR loci appear to be mobile elements with a wide host range.
#=GF CC   This entry represents a protein that tends to be found near
#=GF CC   CRISPR repeats. The species range for this species, so far, is
#=GF CC   exclusively archaeal. It is found so far in only four different
#=GF CC   species, and includes two tandem genes in Pyrococcus furiosus
#=GF CC   DSM 3638. CRISPR is a term for Clustered, Regularly Interspaced
#=GF CC   Short Palindromic Repeats. A number of protein families appear
#=GF CC   only in association with these repeats and are designated Cas
#=GF CC   (CRISPR-Associated) proteins.
#=GF SQ   9
#=GS CAS8A_METJA/25-374      AC Q57830.1
#=GS CAS8_THETK/6-349        AC G4RJZ5.1
#=GS Q8ZZL4_PYRAE/3-344      AC Q8ZZL4.1
#=GS Q9YCM8_AERPE/3-369      AC Q9YCM8.1
#=GS Q8U338_PYRFU/4-348      AC Q8U338.1
#=GS D3RZU0_FERPA/2-379      AC D3RZU0.1
#=GS Q8U337_PYRFU/6-378      AC Q8U337.1
#=GS A1RZX2_THEPD/116-470    AC A1RZX2.1
#=GS A0A2R4ZSQ8_9CREN/3-351  AC A0A2R4ZSQ8.1
CAS8A_METJA/25-374                 ..MLFETPGYNEILDLYIAYGVVECL.VREGVENLRFFPIGNKYCIVVEe....pTNVNIKN..........rIEKGMLNALEDMLSLHKAIGKYist........kediKIISDVDFSAGA------NINNVYwdgipKTLEKIKENIK.KGKLSTKSK--................................--------------NTVPLTLMPAAGKYMPKIYGVK...GGNPIKIDDSNYALAWIGFHYYAPYINI.....SDNRATYIhiYAIKPLEEL......GLIEILALKDLKKKINNYQLGkykfFVNKKLALL.-YHLTHTESISALEIV.TKK..NFSVVSYT..LE-NVDNNQA..IRSFGEYDLSK....LMDFLWYLKATDFYNTIQFV..............DNILRG..............DLEVSLT..FIDGI.......LYDDLDAVYSAIR--KLKS.VRISPLIIQSILEWFGN-f..................
CAS8_THETK/6-349                   qe--MITPGHGIIADALIMHGLIKIL.HIEGKMEGWAERRGERFVVCAE.....rPDLNWIDqwep..melleI-------AAEF----KAKGKDraseeeeqrpyfglvHDLSRSTVDPGNFSSWISDVREAL.....YALKADF-DLS.EEHKEK-----................................-RGEGRARSKKRGYYTLYLPLSGVYGKYVVENYGIR...Q-SQYAVCATCFALSTLGYIYGTVKARVerrssSGGGHDVF.nLTFIPRERT......SLRSLMALQRMAGLV-EMRPG....DLNE----L.-GAVVYMLSVGETIYA.VRE..GVDILVWV..TQ-RAGNFQR..TVGVNIFRGDR....LLEAIAEIKYR-APSWPKI-..............---ARQ..............-LGSSLN.vLGEYL.......AFGG--DVYHVIR------.------------------svmadlgrkggklag....
Q8ZZL4_PYRAE/3-344                 ..KEIYTPGHDVFADTLIMHGVVRHL.AASGIVEGYVERLGERYKISFEgepralADIES--...........VELLLFEIERYVVDGEEPVGRL...............RKIFDANINISATRSWLAQLSEAL.....-----VN----.-AELSVFTLDH................................KAKFREGRTASRRLSTVYLTLSPIYGKYFIENRVAK...ENKAFGVCHTCFAYLNIGFLYGATTIVIi...tRDGRRVVQ..LTPAPRGRI......SIADLALLQRLTEGY------....LVRSQEMPT.LAYPLYWLSTGETLYA.TEE..SLDILVWV..TE-KRGNFQR..VTDAMALDLSR....IMEFIAEVKNK-TRGWPKFV..............ECLALE..............GPEILAQ..LTEVV.......LFGG--DEYTVVRALSTSGkCAEDWRQVDILAEILFTW...................
Q9YCM8_AERPE/3-369                 ..CILYTPGHNLYTDTLILYGIARLL.AWSGKVSGEVERVGERYVVK--......VDADNCHpvsqlpesirlALRLLQEEQQQVFLGDE-----...............----------GTFYSDLYRLARGS.....KVGESILNNLRiRVAAKILSNDAnilek.....................yvspghKKLQGEFRGRKKGLVTLVLPLGPLYGKFYTWSLKPRr.lTEKPYVVCPYCYFLSVLGFHYGSYTYQ-.....KDGESKVV..-TLSPHHA-......SLEDVLALSQSFEAASIWMPA....ILRYRNSLTgPGLSLYVLSLGETLLS.SSS..HFEVLY--..GEFSVDNN--..--TFRVVDVGRlpgvLLTSIAIIKYH-MASWPRLI..............DFIARR..............DPGLLHRiaLTLSFevgneyaLYGILREILSLLNDDKSQE.ARYLAKQLDRLAEGLAM-v..................
Q8U338_PYRFU/4-348                 ..NEFKTPQIDPIFDLYVAYGYVESL.IRGGAKEATLIPHGASYLIQ--......TDVSNEE...........FRHGLVDALSEMLSLHIALARHspr.........eggKLVSDADFSAGA------NINNVYwdsvpRNLEKVMKDLE.K-KRSVKGT--................................--------------ATIPITLMPSAGKYMLKHFGVQ...GGNPIKVDLLNYALAWVGFHYYTPYIKY.....AKGDTTWIhiYQIAPVEEV......DMISILSLKDLKMHLPHYYESnldfLINRRLALL.-YHLLHSESLGALELF.TEK..EFVIHSYT..LE-RSGNNQA..IRSFEEEEIGK....LMDFLWKLKRRDFYHAIKFI..............DDLLKK..............ATEGALA..LIDAI.......MNERLEGFYTALKLGKKAG.VVSSREIVAALEDIICER...................
D3RZU0_FERPA/2-379                 tv--LITPGHHEITDTLIMYGLVEALkMRDPFAEVIVVPSGDRYRIL--......TNIDEGE...........IHYILEEFGKKSYITNLYLYET...............---SQMNILPPV--IRLHMLQRGNe...nRQQENII-NSF.KFLQELSGEISklkknnlikkliyidenhkflesrkeletlcgK----RKKSGKFPSVVANLPIAPFGG-------TLQ...GVGSYYLCKLCVALAWIGLYYYSSRIVLs...sKDSQQTFV..HIFKPESES......KGETILMLKNISQ-INLLRQS...iFKNSNLNLHtSAVPLLLLCFGETSAAiSTV..NLKSIVYTftNE-KKGPTWRtaIRNIATYQVNS....LIKFVEYSKIY-SDKLLRLI..............DVLLRDrd..........sdGMLALST..LSQAI.......IYQDKDQLYSAFREI----.------------------rrvlsknkrenlldqgiik
Q8U337_PYRFU/6-378                 .p-MF-SGYYSRVLNTHIMYGIVESA.LRAGVTNLHVVPTGEGYEIHSR.....yLDCRLKNqedlegegcklLLEGLRDALEEIIMTHYAMGFRskk.........fnnVILSNTVISNGAFIDPPQNVQRYY.....RELEAILNNLDiKSLKSTKSLID................................-----------KKVLRAPQQLDPTLNQWL--SFYKQ...EEGISRITNLEYALAWVGFYYYSSVHKF.....KRGSSQIVeiIQYPPNEEV......EMWELLLIKDLATKI--VQGNdfhwKISSEYGLL.KTLLLTELPPSTEEVP.GLS..KFTVVIYG..QESQQGKGWR..I--FRTLELPV....VWDFIGYLKARAFYETMKFVkilnklertikesqEDILRE..............---ISHQ..LYSAL.......TNRDEMGFYSAFRVLKRAG.YPLDPELVNAIAQYLSER...................
A1RZX2_THEPD/116-470               ..PTLYTPGHSPYTDTLIMHALARAA.WGARDAALRVRGTGFEYVLETS......VDART--...........LAYELRRTFEEV---HAAFLDR...............-----------------QRLGRLFqdkdvRLLDSAL-DPE.GLRAFLEGELS................................RPGHAGAEGRGFDGLTFKLPLMPSAGKYLHTDLTRKpkyEAKEYRVCKYCAALAALGL---ASSVYV.....ARGARVLV..VTLAFSGEAgydalgGYYDFLQGEEAKDVLGVLGPR....VDNVPERLL.AQLAVALLTRNALEAL.DHA..GATWRVYA..VKFDTGRAVQ..VRGFYDVEVDS....VVGAMSSLARVDDASYSKL-..............RDMLKQlaratgadspragyALEALSR..LFEFFetaspdsLYGFARSVYCAYE--GKAG.------FHGVVESLVRAW...................
A0A2R4ZSQ8_9CREN/3-351             .y-TLYTPGHGLVADSLVLHGILRIL.AWCGINKGKVSRFGERFVIELEd...skLNCDKDIiy.......eiLEEVLISVEEYLNVREERRGHReiin......vsdrlSKI------------NYANINKPVl...rNWLSQILDSVE.-------GFISlqvy........................kdpnHKDRFEKSRKGGGLATLYLPLSAIYGKYVQEKKGV-...SESPYKVCDTCFITINMGLLFGTHIVRV....dKKEKSSVY.yTTFIAREDV......DINDLLLLQRMGEGY----HH....VENGAEIPL.ISAPLIAISQGETIAS.VEDpyKIQVLTWS..LQ-LSNNFQR..SLGLSVIDYEP....IYRFVAEIKLR-VPTWPRFL.............nECLLRFe............gGEAVLAS..LTETL.......LFGG--DIYVVSRMLSSH-.------------------imdilkke...........
#=GC seq_cons                      ....hhTPGHs.lsDoLIhaGllctL.htsGhspspV..hG-+YhIp.p......sDscptp...........lthhLhchhcchh.hctshucp.................l.p.sh..us.....tplscsh.....+.L-plh.slc.c.ttph.u..t.....................................thpttththsTl.LsLsPhhGKYh.pphshp...ptssatVCphCaALuhlGahYhoshlpl.....pcGppsll..hshtPpc-s......shh-lLhLpchtptl..h..s....hlNpp.tLL..shsLhhLShGpp.hs.scp..phsllsas..hE.psGNs.p..lhshtsh-lsp....lhcFlu.lKh+.hhsh.+hl..............-slLRp..............s.tshtp..Lh-sl.......lass..slYoshR..pptt........ht.l.phh......................
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