#=GF ID   CdiA_C_tRNase
#=GF AC   PF18664.5
#=GF DE   CdiA C-terminal tRNase domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08616
#=GF GA   26.50 26.50;
#=GF TC   26.60 27.40;
#=GF NC   26.00 25.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   27445337
#=GF RT   Functional Diversity of Cytotoxic tRNase/Immunity Protein
#=GF RT   Complexes from Burkholderia pseudomallei.
#=GF RA   Johnson PM, Gucinski GC, Garza-Sanchez F, Wong T, Hung LW, Hayes
#=GF RA   CS, Goulding CW;
#=GF RL   J Biol Chem. 2016;291:19387-19400.
#=GF DR   INTERPRO; IPR041620;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the C-terminal tRNase domain of CdiA a
#=GF CC   type II toxin/immunity protein complex which can be found in B.
#=GF CC   pseudomallei isolate E479. The C-terminal tRNase domain has an
#=GF CC   alpha/beta-fold characteristic of PD(D/E)XK nucleases. The
#=GF CC   PD(D/E)XK superfamily includes most restriction endonucleases
#=GF CC   and other enzymes involved in DNA recombination and repair [1].
#=GF SQ   34
#=GS A0A1S8CDS7_9GAMM/75-201     AC A0A1S8CDS7.1
#=GS A0A553AD87_9FLAO/243-350    AC A0A553AD87.1
#=GS A0A8J3Q6X8_9ACTN/204-295    AC A0A8J3Q6X8.1
#=GS A0A7W5FBY5_9ACTN/284-377    AC A0A7W5FBY5.1
#=GS A0A2T5IUF2_9GAMM/1-75       AC A0A2T5IUF2.1
#=GS A0A1V9FY21_9BACT/2991-3104  AC A0A1V9FY21.1
#=GS A0A1V0PZS4_9RHOB/40-151     AC A0A1V0PZS4.1
#=GS A0A083ZVM1_9GAMM/167-283    AC A0A083ZVM1.1
#=GS A0A1S9ZV52_9GAMM/296-418    AC A0A1S9ZV52.1
#=GS B2FLL9_STRMK/3400-3514      AC B2FLL9.1
#=GS A0A8J7IKN6_9FLAO/239-346    AC A0A8J7IKN6.1
#=GS A0A084A2P0_9GAMM/158-280    AC A0A084A2P0.1
#=GS A0A0H5CR21_9PSEU/126-219    AC A0A0H5CR21.1
#=GS A0A378TC45_9MYCO/10-108     AC A0A378TC45.1
#=GS A0A0C5UZG6_9GAMM/543-659    AC A0A0C5UZG6.1
#=GS A0A085HKY2_9GAMM/471-587    AC A0A085HKY2.1
#=GS A0A2W2F0E5_9ACTN/295-390    AC A0A2W2F0E5.1
#=GS A0A0N0VIV9_9PSED/3256-3370  AC A0A0N0VIV9.1
#=GS A0A8J8GXP8_9ACTN/49-144     AC A0A8J8GXP8.1
#=GS A5UV07_ROSS1/12-118         AC A5UV07.1
#=GS A0A847SB71_9NEIS/438-561    AC A0A847SB71.1
#=GS A0A083ZVL8_9GAMM/219-344    AC A0A083ZVL8.1
#=GS A0A381E665_9GAMM/198-318    AC A0A381E665.1
#=GS A0A377QZ45_9NEIS/322-447    AC A0A377QZ45.1
#=GS A0A370Q339_9GAMM/528-650    AC A0A370Q339.1
#=GS A0A0A0B1I9_9CELL/756-850    AC A0A0A0B1I9.1
#=GS D9TBI6_MICAI/297-388        AC D9TBI6.1
#=GS A0A8J8KFM6_9ACTN/40-132     AC A0A8J8KFM6.1
#=GS A0A8J3BY27_9ACTN/293-389    AC A0A8J3BY27.1
#=GS A0A495X7X6_9PSEU/40-109     AC A0A495X7X6.1
#=GS A0A0H5CSP6_9PSEU/123-216    AC A0A0H5CSP6.1
#=GS A0A1S8CDJ6_9GAMM/75-197     AC A0A1S8CDJ6.1
#=GS A0A083ZVM4_9GAMM/1-110      AC A0A083ZVM4.1
#=GS A0A892ZJV8_9NEIS/586-712    AC A0A892ZJV8.1
A0A1S8CDS7_9GAMM/75-201                .....................PAEAAAAARLETALGK-LERI...TTSSTd......knADFIITSGP...YAGKTVDLMYTTKNLSQKEIDGINKFYEKN...M..TTskspgdiphGQDQILQH.LKK...A..DLV...PVDFSI..LTQKNQAIFMDFIKTLP.KEQQDKIIIM........
A0A553AD87_9FLAO/243-350               ...................qi--EAEGMAIFEETFNTTVRAIr.nGEQKA.........GDFIITQGK...LAGKSVDLVSAVDK----------KGF--K...L..DA.........FIKSIDSHfLKD..gV..DFI...NIDIRK..LGNDAKQVVKKHIGESS.KANQARTII-t.......
A0A8J3Q6X8_9ACTN/204-295               ....................a-GEADTAVRVEEATGTTLSR-...STDPS.........VDWVDNA--...-TGKTYDAVGNFPQ----------QHFDAQ...W..PN.........LQTKIIDH.LAK...A..DYV...PVDVSQ..WTPDQIAKVQKFIT---.----------dng.....
A0A7W5FBY5_9ACTN/284-377               .....................PEESESAQRIEAETGVRLTRA...ETGSS.........ADWVDES--...--GKTYDAVGNFDS----------RYFERQ...W..PQ.........LQFQIERH.LDK...A..DLV...PVDVSR..FTPEQKAMVERFIE---.----------qrglg...
A0A2T5IUF2_9GAMM/1-75                  ...................md---------------------...-----.........---------...-----------------DNINRLNQFYEKN...M..TVlnpksnvieGIEQIKEH.VQK...S..DFV...PVDFRI..LNSKNQQIFMNFVKTLP.KSAQEKFIIM........
A0A1V9FY21_9BACT/2991-3104             ...................ef--EAESGALLEEAYDIKLREL...KPGEI.........GDYAVESGK...INGINVAGKTIDQT--GVPLSGVGKF---K...M..EK.........FYAQIKRH.LREkqgA..YFI...LIDLRH..FSEQERAEVLKHLSDNF.SNDASRIIT-i.......
A0A1V0PZS4_9RHOB/40-151                ....................s-NEANTANALEHVLGKRLERS...QKNIG.........GDWVSRG--...-AGGAVDKVYDDCS------PPRHAFFETQ...F..DN.........FRASLKRHtSQK...SgiHVV...VVDVRNrdLTPDQIKRVLSVIKELS.PGERKKVLLL........
A0A083ZVM1_9GAMM/167-283               ....................l-AEGSAASELQNSMGGNLERV..dPDISG.........ADFIFTSGP...NKGKTVDFMFTTAKGTAKEIEGMNKFFNNN...W..DK.........NVAQLHTH.LNK...A..DIV...PLDFRN..LNAENQQRLLSYINTLS.PADKAKVVIM........
A0A1S9ZV52_9GAMM/296-418               ....................l-HEAMAAAQYQAFFGVRLIRP...--KPEfvngnakagFDYLV---E...QTGKRIDFMFTMHGYPKKKIEKLNQFFAHNdttW..AD.........KKDDIQSH.LRK...A..DIV...PLDLRY..LTDENRTMLIQHVLSLP.VKQQKQILF-i.......
B2FLL9_STRMK/3400-3514                 ....................v-HEGQAAVQLENSLGGTLKRT...DPVQGs......knPDFVFVSGP...YAGKTVDFMWTDGT----KSTQINKFFSNN...S..AQ.........NQRQLIDH.VNK...A..DMV...PLDYRN..LAPENQALVNSWIKMLT.PEQQGKIIIL........
A0A8J7IKN6_9FLAO/239-346               ...................qv--EAEGIAIFEETFKTTARAIk.nTDTKA.........GDFIVTSGK...YQGKSVDLVSAVDH---------PKFD---...T..KR.........FIKSIDEH.FDKd.gV..DFI...NVDIRN..LDDAGKELVKKHISNLS.EANKAKTIL-t.......
A0A084A2P0_9GAMM/158-280               .....................PAEAASAAQLEPTLGT-MERY...TPPPGmit...dktPDFVITSGP...NKGKTVDAMYTTDRLSQKEIDGLNKFYEKN...M..SAg.......sGRDVIQNH.LQK...A..DFV...PVDFRV..LTPANQKIFMDYIKTLP.KVQQDKIIIM........
A0A0H5CR21_9PSEU/126-219               .....................PGESQTARRIEDKRRTALVRS...PDETG.........PDWIGP---...-DGRTYDAVGNFPG----------EFLDRQ...W..KK.........FTERIVDH.MDK...S..YYV...PVDVSQ..FSPEQVKRVQEFIGP--.----------lgpr....
A0A378TC45_9MYCO/10-108                .....................PAEAETGLRIENETGVTLERL...PGDSP.........GDWRDTA--...-TGKTYDAVGNFDG----------KFFDKQ...W..AN.........LKEQILKH.LDK...A..DFV...PIDVSK..FTPEQTQKVKVFLEGLH.----------tdrafi..
A0A0C5UZG6_9GAMM/543-659               .....................PGEAGAAAEMEYYLGGTLDRA...PGGTS.........ADFVVNSGD...FAGARIDLKLTPDT--FDQASKINQYFDKT...F..PK.........FSQSVANK.LAK...P..DGVdlmPFDTRF..LTEQNKSRLFEFVETLP.ASSQQKVIYL........
A0A085HKY2_9GAMM/471-587               .....................PAEASAAVEIQNSLGGTLKRI...GDGEG........lGDFIFTSGP...NKGKTVDFMFTTANGTSKEITGINQFFNNN...W..EK.........NVKVLEDH.LKK...A..DFV...PLDFRV..LNHINQQRLMDHIKTLS.ASEQKKIIIM........
A0A2W2F0E5_9ACTN/295-390               .....................PGEADTAVRLERELGVRLTRA...PADSS.........ADWVD----...STDRTYDAVGNFPG----------QFFDRQ...W..PQ.........LQYQIERH.LDK...A..DFV...PVDVSR..FSAEQVARIEQFIT---.----------drglapr.
A0A0N0VIV9_9PSED/3256-3370             ....................l-HEGQVAVQLENTFGSTLKRVeplKDGKN.........PDFVFVDGP...YSGKTVDFLWTDSS----RADQINKFFSNN...S..AK.........NREQLIDH.INK...A..DMV...PLDYRV..LSSENQSMVNGWIKTLS.VEQQGKLLIL........
A0A8J8GXP8_9ACTN/49-144                ....................r-SEAETAWRVQDSLGVQLRR-...SPDPN.........VDWI----D...ATGRTVDAVGNFPG----------RHFERQ...W..PN.........LQARIRDH.LEK...A..ELV...PVDVAQ..FSPEQIARVRRFID---.----------dnalgpra
A5UV07_ROSS1/12-118                    .....................PHEGEVGAIIEDWFGG-LRR-...SPDPE.........ADWIGTSGS...YEGKTFDLIGLPRG--------ASAFHSDN...M..EN.........FLPAVDMHfLKS...V..DYI...VLDVRF..MTPAQKETVLRHINAQW.ASEKSRLILV........
A0A847SB71_9NEIS/438-561               .....................PAEAAAGAQLEDALGA-MKRY...EPSLTqga..ndknPDFVIIDGP...YKGKTVDAMYTTGQLTKKEIDGINKFFEKN...MilGK.........EKENILNH.LDK...A..DFV...PVDFRV..LTQNNQQIFMNYIGTLP.AAQRAKIIIV........
A0A083ZVL8_9GAMM/219-344               ..................ynp---AEAAARLEGVLGP-LERA...PNTGQk.......aTDFIITSGP...NAGKTVDLMYTTKNLSQKEIDGMNKFFEKN...M..TVtpqgqnipgGQKQILEH.LEK...A..DIV...PVDFTV..LTPLNQKIFMDFIIKLP.KNQTDKIIIM........
A0A381E665_9GAMM/198-318               ....................h-GEAGAAVELQNILGGKLRRLn.eKDNSN.........ADFVIEGGP...NNGKTVDFMFTVNN--ERSRIGINDYFIKN...F..NRrk.....agIKDTLIDH.TNK...A..HIV...PLDFRN..LNPENRAMVTDFINREMtKEQKSQIIIM........
A0A377QZ45_9NEIS/322-447               ....................r-HEAETAAQWQQAHGVRLEPY...DLEKAg......gkPDFLIADQDlprSQWQTIDFMFTEDPGNEFKIGKFNQYFADT...A..SHw......tdQVKQIQKH.LAK...A..DIV...PLDLRR..LNALNRAKVLGYVLSLP.QEQQDKIYI-il......
A0A370Q339_9GAMM/528-650               .....................PAEAATAAQLEPALGQ-MERY...TPPKGats...gtsPDFVITSGP...NKGKTVDAMYTTDKLSQKEIDGLNKFYEKN...M..SSg.......sGKDVIQDH.LKK...A..DFV...PVDFRV..LTRTNQKIFMDYIKTLP.KTQQDKIIIM........
A0A0A0B1I9_9CELL/756-850               .....................PSEYQTAQRIIEERGVEITRA...PKGSS.........ADWVD----...SAGNTYDAVGNFPG----------EFFDDQ...W..PN.........LAEQIVKH.LDK...A..DFV...PVDVSR..FSPEQIARVREFIEPLS.----------prv.....
D9TBI6_MICAI/297-388                   .....................PAEAETAVRVEEHLGVRLRRA...PSDSS.........ADWV----D...EAGRTYDAVGNFPG----------QYFDRQ...W..PQ.........LQYQIERH.LEK...A..DLV...PVDVSR..FSAQQTAMVEQFI----.----------adrg....
A0A8J8KFM6_9ACTN/40-132                .....................PAEAETARRVEELLGIELER-...SANPD.........VDWVD---P...ATGLTYDAVGNFDA----------RYFDRQ...W..PN.........LQTRIIDH.LAK...A..DRV...PIDVAR..FTSAQIATVQKFL----.----------adnsl...
A0A8J3BY27_9ACTN/293-389               .....................PTEAETARRLERERGITLTRA...PSSSR.........ADWFD----...ETDRSYDAVGPFDP----------KYFERQ...W..RR.........FSEQIVLH.LKK...A..DLV...PVDVSQ..FTPQQVARIEAFIA---.----------rtnlaprv
A0A495X7X6_9PSEU/40-109                sgdgydhngitydalgpfpcp---------------------...-----.........---------...------------------------EYFMQN...W..EQ.........TKRGLVAH.LEK...A..DIM...PIDVTG..LSPEQVKMIVDFIAPL-.----------gpr.....
A0A0H5CSP6_9PSEU/123-216               ...................rg--ETVTARRVEDERRTVLVRS...TRKKG.........PDWIGP---...-DGKTYDAVGPFAG----------KYFDRQ...W..EI.........FQGRIVDH.MTK...A..DWV...PVDVSQ..FTPEQIARVREFIG---.----------plgpr...
A0A1S8CDJ6_9GAMM/75-197                .....................PAEAASAAQLESTLGT-MERY...TPSPGaks...gtsPDFVITSGP...NKGKTVDAMYTTDKLSQKEIDGLNKFYEKN...M..STg.......sGRDVIQDH.LQK...A..DFV...PVDFRV..LTPANQKIFMDYIKTLP.KVQQDKIIIM........
A0A083ZVM4_9GAMM/1-110                 .....................-----------------MERAp.nTGQKA.........TDFIITSGP...NAGKTVDLMYTTKNLSQKEIDGMNKFFEKN...M..TVtpqgqnipgGQKQILEH.LEK...A..DIV...PVDFTV..LTPLNQKIFMDFIIKLP.KNQTDKIIIM........
A0A892ZJV8_9NEIS/586-712               ....................e-HEAIAAAQWEQAFGVRLQPY...DGVGNky.....gkPDYYITDNKlpkKQWQTLDFMFTADIDDTKSIHNLNRFFAHTtdgW..KD.........KQRRIQLH.LLK...S..DIV...PLDLRH..LNTENRARLLSYVLSLT.KEQQNQI---kliv....
#=GC seq_cons                          ......................tEApsAsplEpthGspLcRh...sssps.........sDalh.s......sG+TlDhhhshss..........cFF-+p...h..sp.........hpcpIhcH.LpK...A..DhV...PlDhpt..LospppthlhcaIptL....pptphhh.........
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