#=GF ID CelTOS
#=GF AC PF18659.5
#=GF DE Cell-traversal protein for ookinetes and sporozoites
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08213
#=GF GA 27.20 27.20;
#=GF TC 27.80 45.10;
#=GF NC 27.10 24.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 27906127
#=GF RT Malaria parasite CelTOS targets the inner leaflet of cell
#=GF RT membranes for pore-dependent disruption.
#=GF RA Jimah JR, Salinas ND, Sala-Rabanal M, Jones NG, Sibley LD,
#=GF RA Nichols CG, Schlesinger PH, Tolia NH;
#=GF RL Elife. 2016; [Epub ahead of print]
#=GF DR INTERPRO; IPR041004;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Cell-traversal protein for ookinetes and sporozoites (CelTOS) is
#=GF CC a conserved protein that is essential for traversal of malaria
#=GF CC parasites in both the mosquito vector and human host and is
#=GF CC therefore critical for malaria transmission and disease
#=GF CC pathogenesis. It specifically binds phosphatidic acid commonly
#=GF CC present within the inner leaflet of plasma membranes, and
#=GF CC potently disrupts liposomes composed of phosphatidic acid by
#=GF CC forming pores. CelTOS resembles class I viral membrane fusion
#=GF CC glycoproteins and a bacterial pore-forming toxin with roles in
#=GF CC membrane binding and disruption. CelTOS forms an alpha helical
#=GF CC dimer that resembles a tuning fork. Structure analysis indicate
#=GF CC that it has a distinct structural architecture with two
#=GF CC subdomains that independently resemble membrane binding and/or
#=GF CC disrupting proteins and could simultaneously act during
#=GF CC disruption [1].
#=GF SQ 31
#=GS I7J9D8_BABMR/26-142 AC I7J9D8.1
#=GS A0A1A8X4B1_9APIC/39-154 AC A0A1A8X4B1.1
#=GS L0AZQ6_THEEQ/25-148 AC L0AZQ6.1
#=GS A0A1D3UA29_9APIC/39-154 AC A0A1D3UA29.1
#=GS A0A1Y1JPX8_PLAGO/40-155 AC A0A1Y1JPX8.1
#=GS A5JZX5_PLAVS/50-165 AC A5JZX5.1
#=GS A0A024VMX1_PLAFA/39-154 AC A0A024VMX1.1
#=GS A0A384KT14_PLAKH/39-154 AC A0A384KT14.1
#=GS W4J1M3_PLAFP/39-154 AC W4J1M3.1
#=GS Q8I5P1_PLAF7/39-154 AC Q8I5P1.1
#=GS A0A024W4Q4_PLAFA/39-154 AC A0A024W4Q4.1
#=GS A0A024X5U3_PLAFC/39-154 AC A0A024X5U3.1
#=GS A0A2H6K9N2_9APIC/28-147 AC A0A2H6K9N2.1
#=GS A0A653GY22_9APIC/34-155 AC A0A653GY22.1
#=GS A0A0L1I7D4_PLAFA/19-134 AC A0A0L1I7D4.1
#=GS A0A1A8ZYT3_9APIC/39-154 AC A0A1A8ZYT3.1
#=GS Q4UGH3_THEAN/111-234 AC Q4UGH3.1
#=GS A0A0L7MAD8_PLAF4/1-50 AC A0A0L7MAD8.1
#=GS A0A0L7KHG1_PLAFX/21-136 AC A0A0L7KHG1.1
#=GS A0A1A8X2H8_PLAMA/39-154 AC A0A1A8X2H8.1
#=GS J7M8E0_THEOR/26-149 AC J7M8E0.1
#=GS A0A1J1HB15_PLARL/39-156 AC A0A1J1HB15.1
#=GS W7JVD3_PLAFA/39-154 AC W7JVD3.1
#=GS A0A0L7LZU0_PLAF4/39-154 AC A0A0L7LZU0.1
#=GS W7JS91_PLAFO/39-154 AC W7JS91.1
#=GS A0A509AQS4_PLABA/39-154 AC A0A509AQS4.1
#=GS A0A061DAC2_BABBI/37-156 AC A0A061DAC2.1
#=GS Q4N982_THEPA/30-153 AC Q4N982.1
#=GS A0A024WNX5_PLAFA/39-154 AC A0A024WNX5.1
#=GS K6VI33_PLACD/20-135 AC K6VI33.1
#=GS A0A1X1BHQ8_9APIC/30-147 AC A0A1X1BHQ8.1
I7J9D8_BABMR/26-142 ....gypsd--------VTKAHDYNLKRAIRSELETASDQIVEIIAQHVEKILQEQSPDETSFIQ..DG--WK...STAKKITKNAVVHIAKNTIPVIAAIVADSVKPPNTDVIVYNSLFKPVCKDIFDHVSAKL-d
A0A1A8X4B1_9APIC/39-154 ........s-GSEFSQRINNSLSSFISG--SATLDKVGDDLADNIASEIVSALQNEG---ASFLQ..SGFDVK...QQLKTHAKKILLEAVKAGLGPVEKIVADSVKPPRTSGHVYN-LLGPTLRTLFNKIEDAVH.
L0AZQ6_THEEQ/25-148 ........a-PSLYTSFSQKTYVDRISKIIRNDLDSKVDEIVDILASDLEKELGKNGLLAASYLEtvSGNGWA...KQAKVIVKKTLLSIIKRMIPLFDMWIHDAVQPPVVDRLVYKLLVHPLGFGISEELRNKLH.
A0A1D3UA29_9APIC/39-154 ........s-GSEFSQRINNSLSSFISG--SATLDKVGDDLADNIASEIVSALQNEG---ASFLQ..SGFDVK...QQLKTHAKKILLEAVKAGLGPVEKIVADSVKPPRTSGHVYS-LLGPTLRTLFNKIEDAVH.
A0A1Y1JPX8_PLAGO/40-155 ........a-GTEFSERIGNSLSSFLSE--SSSLEVIGNELADNIANEIVNSLQKDS---ASFLQ..SGFDVK...SQLKTTAKKVLLEALKAALEPTENIVASTIKPPRVSEEVYF-LIGPVVKTLFNKVEDVLH.
A5JZX5_PLAVS/50-165 .........GGSEFSERIGNSLSSFLSE--SASLEVIGNELADNIANEIVSSLQKDS---ASFLQ..SGFDVK...TQLKATAKKVLVEALKAALEPTEKIVASTIKPPRVSEDAYF-LLGPVVKTLFNKVEDVLH.
A0A024VMX1_PLAFA/39-154 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKNHAKSMLKELIKVGLPSFEKLVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
A0A384KT14_PLAKH/39-154 .........GGSEFSERIGNTLSSFLSE--SASLEVIGNELADNIANEIVGSLQNDS---ASFLQ..SEFDVK...AQLKATAKKVLTEALKAALEPTEKIVASTIKPPRIKEDIYF-LLSPVVRSLFNKVEDVLH.
W4J1M3_PLAFP/39-154 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKKHAKHMLKELIKLGLPSVEKVVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
Q8I5P1_PLAF7/39-154 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKKHAKSMLKELIKVGLPSFENLVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
A0A024W4Q4_PLAFA/39-154 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKSHAKFMLKELIKVGLPSFEKVVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
A0A024X5U3_PLAFC/39-154 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKKHAKHMLKELIKLGLPSVEKVVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
A0A2H6K9N2_9APIC/28-147 .....nqps----KSINIHDADIEKFRDIVRKDIADKTDELIGLIVKDVEKLIEENDMVRPVFLE..NA--LK...ENAKKMIKTGVISIIKHMVPVFERWIVEAIKPPVTSAMVYTALIKPIGKSIFDQLYHKFN.
A0A653GY22_9APIC/34-155 sflqnnltl-----EDSIRSNFSSFLNE--STSLETVTDNIAQAFVNELFVQLNNKS-KEASFLQ..TEFNIK...AEMKKQAKNLFLVAMKQGLEPVETLIAESIKPPTLKPHAYS-LVSKVLMELFNHVEKKLK.
A0A0L1I7D4_PLAFA/19-134 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKKHAKSMLKELIKLGLPSVENLVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
A0A1A8ZYT3_9APIC/39-154 ........s-GSEFSERINNSLSSFISG--SATLDKVGDDLADNIASEIVSALQNEG---ASFLQ..SGFDVK...QQLKTHAKKILLEAVKAGLGPVEKIVADSVKPPRTSGHVYS-LLGPTLRTLFNKIEDAVH.
Q4UGH3_THEAN/111-234 .........GPAKKSSFVEKSNVEKLTKVLREDLNSKVDEVVDLIATDLERELLKNGLTNLSLMQ..QS-DAKafgGKAKEIIKKTLIGVMRSLIPVFERWIHDSVQPPVVDRHVYTVLIHPIGYRICEQIHEKLK.
A0A0L7MAD8_PLAF4/1-50 .......ms--------------------------------------------------------..------...-----------KELIKVGLPSVEKLVAENAKPPQVEPASYG-IIVPVLTSLFYKIETAV-g
A0A0L7KHG1_PLAFX/21-136 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKKHAKSMLKELIKVGLPPVEKLIAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
A0A1A8X2H8_PLAMA/39-154 .........NGSEFSERLNKSFSSFISE--SASVEEIGNEIADNIANEIISALQKDS---VSFLQ..SGFDIK...RQLKENAKVVLKEVLKQGLEPIENIVADAVKPPHTNPQVYH-LLSPVLKTLFNRMEQAVH.
J7M8E0_THEOR/26-149 .........GPSKNSSFVQKASIERLTKVIRDDLNSKVDEVVDLIATDLERELLKGGLTNLSLLQ..QG-NVGgmgAKAKQVIKKTLVGVLKSVVPMFETWIHDAVQPPVVDRNVYSALIQPVGFGISEQLHEKLH.
A0A1J1HB15_PLARL/39-156 ......nen---QIYDHSNNKISSFILQ--SQSLEMVSDELADSIANEIVNALQKDS---SSFLQegIGFDIK...GQIKKHAKEVLKEVAKAGIQPIEEVVAASVKPPTISPHAYK-LLKPVLKTLFNKVEQTI-k
W7JVD3_PLAFA/39-154 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKKHAKSMLKELIKVGLPSVEKVVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
A0A0L7LZU0_PLAF4/39-154 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKKHAKLMLKELIKVGLPSVEKLVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
W7JS91_PLAFO/39-154 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKKHAKSMLKELIKVGLPSFENLVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
A0A509AQS4_PLABA/39-154 .........GGVESSNRIKKSLASFISE--SSSLDDIGNGLAETITNEIFSAFQQDS---SSFLQ..TKFDIK...KHIKENAKKVLIEAIRLGLEPVEKIVAQSIQPPKVNRHTYS-LVSPVVKALFNKIEEAVH.
A0A061DAC2_BABBI/37-156 .........NDTDVETYLQHDISTEFRDIVRRDIADKTDELISLIVKDVEKLIEQNDMVRPVFLE..NA--LK...ENAKRMIKSGVISIVKHMVPVFERWIVEAIKPPVTSGMVYTALVKPIGKSIFDQLYHKFN.
Q4N982_THEPA/30-153 .........GPSKKSSFVEKSNVEKLTKVLREDLNSKVDEVVDLIATDLERELLKNGLTNLSLMQ..QS-DVKgfgSKAKEIIKKTLVGVMRSLLPVFERWIHDSVQPPVVDKHVYGVLIHPIGYRICEQIHEKLK.
A0A024WNX5_PLAFA/39-154 .........NGSQFIEQLNNSFTSAFLE--SQSMNKIGDDLAETISNELVSVLQKNS---PTFLE..SSFDIK...SEVKKHAKSMLKELIKLGLPSVEKVVAENVKPPKVDPATYG-IIVPVLTSLFNKVETAV-g
K6VI33_PLACD/20-135 .........GGSEFSERIGNSLSSFLSE--SASLEVIGDELADNIANEIVSSLQKDS---ASFLQ..NGFDVK...TQLKATAKKVLMEALKAALEPTERIVATTIKPPRVSEEAYF-LLGPVVKTLFNKVEDALH.
A0A1X1BHQ8_9APIC/30-147 ....paqgi-------TITNAQVEKFRDLVKTDLAQKVDDLIELIVADVERAIVENGEAHAAFIQ..TG--IN...ENVKKMVKQAALTMVKHLIPVFEGWIADAVRPPVTTPTVFNMLIKPVCQSIFDNIYLKL-k
#=GC seq_cons .........sGSpF.-plsNShoSthh-..SpSlsplGD-LA-sIuNElVusLQKsS...soFLp..SuFDlK...uplKcpAKphLhEllKsGLPshE+lVA-sVKPP+VcstsYs.LlsPVlpoLFNKlEssl..
//
