#=GF ID   Chp1-like_PIN
#=GF AC   PF21484.1
#=GF DE   Chromo domain-containing protein 1-like, PIN domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   ECOD:EF20697
#=GF GA   27.00 27.00;
#=GF TC   28.50 28.30;
#=GF NC   26.70 24.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0280
#=GF RC   Paper describing PDB structure 3tix
#=GF RN   [1]
#=GF RM   22081013
#=GF RT   The Chp1-Tas3 core is a multifunctional platform critical for
#=GF RT   gene silencing by RITS.
#=GF RA   Schalch T, Job G, Shanker S, Partridge JF, Joshua-Tor L;
#=GF RL   Nat Struct Mol Biol. 2011;18:1351-1357.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found at the C-terminal end of Chromo domain-
#=GF CC   containing protein 1 from Schizosaccharomyces pombe (Chp1) and
#=GF CC   similar proteins predominantly found in yeast. Chp1 is a
#=GF CC   component of the RNA-induced initiation of Transcriptional Gene
#=GF CC   Silencing (RITS) complex, a central player RNA interference
#=GF CC   (RNAi) pathway which is important for heterochromatin formation
#=GF CC   and accurate chromosome segregation. This entry represents the
#=GF CC   PIN domain of Chp1, which shows an alpha-beta fold [1].
#=GF SQ   8
#=GS A0A0E9N9E3_SAICN/817-962  AC A0A0E9N9E3.1
#=GS A0A8H4AD44_GIGMA/402-548  AC A0A8H4AD44.1
#=GS A0A2Z6R0E0_9GLOM/650-800  AC A0A2Z6R0E0.1
#=GS CHP1_SCHPO/810-956        AC Q10103.1
#=GS B6K5E2_SCHJY/927-1074     AC B6K5E2.1
#=GS A0A2P4QGN1_RHIID/2-61     AC A0A2P4QGN1.1
#=GS A0A015K0U9_RHIIW/655-806  AC A0A015K0U9.1
#=GS A0A015N897_RHIIW/497-648  AC A0A015N897.1
A0A0E9N9E3_SAICN/817-962             .......HGGVIVMTSEMIINSPNIVEFVLGYAEY--GGWNVMVCPGLITEVEAFCHqglTGESDEAGK.EFGDVLLTILAIKEALDKKRVVEFVL--LEERETI..CQS..L.LASLRLYQVWSCETYRRFIVLHSVKDD.tE....QEWTQGIEVHTPDQFL------kmka
A0A8H4AD44_GIGMA/402-548             ......s-GGIIVITERALLKYDQILGNMQRFLEH-NPEWVLKIPSSILEKLQVKYL...TQY-NAHYY.TLQRLRDEMSFLTNECGSIKFLLPDEIKDEEIFDM..NEY..C.YSSMNVLFNKYYNSYRYFIIIDDQ-KYslE....MTTVYGIEVMTLDEFERKI---fhi.
A0A2Z6R0E0_9GLOM/650-800             ......l-GGVILVTSTAIKNTDNIIDSILYFTNL-VNGWDFKIHPNILSYLQRLLT...FLSGNEFLRvRLD---KAFKSIVNGLISGNIKYLLPNEMPLDDYN..MDSrkLtFDSMECLSKTNYNKYHRFVVIDDTDEI..DeqyvENEKKGIETMTIEKFKQKFV--n...
CHP1_SCHPO/810-956                   .......KGGVVSVTLSALIKTPRLLELISPFLEIKKDSWILILPPSIVDMVKSYFV...TNNPDKSLL.EIQNLLNTLQRYLTNPALKNVTLYQDWDIVIDDSA..DVS..L.ASTLQLYQKKNYDKYRRFVLIHEL-KN..E....LTPVNGLDIVDYDEFKETFMRA....
B6K5E2_SCHJY/927-1074                .......RGGILSVTPIAFIKKPDIIKSVLPFIQLKITSWRFVLPVGYITMLRSCFE...KYFPNEPSK.KLNDCIATYNRLMEEAGSSTIMMLQDWEVIESEDE..SET..L.LNSLLFYQQKHYEQYRRFVLLHDVQKF..P....LKEPNGIETLTFNDFRQRFMST....
A0A2P4QGN1_RHIID/2-61                dsrkltf--------------------------------------------------...---------.-----------------------------------..---..-.-DSMECLSKTNYDKYHHFVVIDDTDEI..DeqyiENEMKGIETMSIEKFKQKFMS-i...
A0A015K0U9_RHIIW/655-806             ......s-GGVILVTSTAIKNTDNIIDSILYFTNL-VNGWDFKIHPNILSYLQRLLT...FLSDNEFLRvRLNKAFKSIEDGLI---SGNIKYLLPNEMPLDDYNmdSRK..LtFDSMECLSKTNYDKYHHFVVIDDTDEI..DeqyiENEMKGIETMSIEKFKQKFMS-i...
A0A015N897_RHIIW/497-648             ......s-GGVILVTSTAIKNTDNIIDSILYFTNL-VNGWDFKIHPNILSYLQRLLT...FLSDNEFLRvRLNKAFKSIEDGLI---SGNIKYLLPNEMPLDDYNmdSRK..LtFDSMECLSKTNYDKYHHFVVIDDTDEI..DeqyiENEMKGIETMSIEKFKQKFMS-i...
#=GC seq_cons                        ........GGVIlVTspAlhpossIl-slLhFhpl.hsuWshhl.PsIlohLpphhp...hhpsNEhh+.cLschhpohpphhpt..Stslhhh.s.-h..c-.t..scp..L.hsSMcsLpKpNY-KY++FVVIDDsc-h..-....psEhpGIETMol-cFKQKFMp.h...
//