#=GF ID CoV_NSP2_C
#=GF AC PF19212.4
#=GF DE Coronavirus replicase NSP2, C-terminal
#=GF PI Corona_NS2_C;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE Bateman A
#=GF GA 25.00 25.00;
#=GF TC 25.00 26.10;
#=GF NC 24.00 21.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 16227261
#=GF RT The nsp2 replicase proteins of murine hepatitis virus and severe
#=GF RT acute respiratory syndrome coronavirus are dispensable for viral
#=GF RT replication.
#=GF RA Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR;
#=GF RL J Virol. 2005;79:13399-13411.
#=GF RN [2]
#=GF RM 32586950
#=GF RT Structural insight into precursor ribosomal RNA processing by
#=GF RT ribonuclease MRP.
#=GF RA Lan P, Zhou B, Tan M, Li S, Cao M, Wu J, Lei M;
#=GF RL Science. 2020;369:656-663.
#=GF RN [3]
#=GF RM 34159380
#=GF RT Nsp2 has the potential to be a drug target revealed by global
#=GF RT identification of SARS-CoV-2 Nsp2-interacting proteins.
#=GF RA Zheng YX, Wang L, Kong WS, Chen H, Wang XN, Meng Q, Zhang HN,
#=GF RA Guo SJ, Jiang HW, Tao SC;
#=GF RL Acta Biochim Biophys Sin (Shanghai). 2021;53:1134-1141.
#=GF DR INTERPRO; IPR043613;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry corresponds to a presumed domain found at the
#=GF CC C-terminus of Coronavirus non-structural protein 2 (NSP2). NSP2
#=GF CC is encoded by ORF1a/1ab and proteolytically released from the
#=GF CC pp1a/1ab polyprotein and its function is unclear. Viral-host
#=GF CC protein interaction studies in SARS-CoV and SARS-CoV-2 found
#=GF CC that this protein could interact with several host proteins,
#=GF CC including prohibitin 1 (PHB1) and PHB2, which are implicated in
#=GF CC a number of cellular functions, including cellular migration,
#=GF CC differentiation and apoptosis [2,3]. This presumed domain is
#=GF CC found in two copies in some viral NSP2 proteins. This domain is
#=GF CC found in both alpha and betacoronaviruses.
#=GF SQ 121
#=GS B1PHI6_9ALPC/474-590 AC B1PHI6.1
#=GS Q6R1L9_CVHNL/476-592 AC Q6R1L9.1
#=GS S5YAF0_9ALPC/473-590 AC S5YAF0.1
#=GS A0A088DIE1_9BETC/685-814 AC A0A088DIE1.1
#=GS A0A059VJE6_9ALPC/475-592 AC A0A059VJE6.1
#=GS C6GHB6_9ALPC/465-584 AC C6GHB6.1
#=GS A0A1L2KGC1_9ALPC/779-897 AC A0A1L2KGC1.1
#=GS R1A_CVH22/777-897 AC P0C6U2.1
#=GS A0A0K1YZY7_SARS/690-818 AC A0A0K1YZY7.1
#=GS K4K1U5_9ALPC/773-890 AC K4K1U5.1
#=GS A0A125R5A3_9ALPC/768-879 AC A0A125R5A3.1
#=GS R1AB_CVH22/777-897 AC P0C6X1.1
#=GS A0A0U1UZA8_9ALPC/475-591 AC A0A0U1UZA8.1
#=GS A0A0U1WHC6_9ALPC/476-592 AC A0A0U1WHC6.1
#=GS A0A3G8EYU2_9ALPC/655-771 AC A0A3G8EYU2.1
#=GS A0A240FW17_9ALPC/432-553 AC A0A240FW17.1
#=GS B1PHK0_9ALPC/476-592 AC B1PHK0.1
#=GS R1A_BCHK5/715-851 AC P0C6T5.1
#=GS A0A0U1UZC3_9ALPC/477-594 AC A0A0U1UZC3.1
#=GS A0A2Z4EVM4_9NIDO/637-763 AC A0A2Z4EVM4.1
#=GS Q6R1L8_CVHNL/476-592 AC Q6R1L8.1
#=GS R1AB_FIPV/465-584 AC Q98VG9.2
#=GS A0A0U1WHC6_9ALPC/774-891 AC A0A0U1WHC6.1
#=GS A8JNZ0_9ALPC/776-896 AC A8JNZ0.1
#=GS R1AB_CVPPU/768-879 AC P0C6Y5.1
#=GS E0ZN51_BCHK9/646-772 AC E0ZN51.1
#=GS A0A1L2KGC3_9ALPC/475-592 AC A0A1L2KGC3.1
#=GS A3EXI9_BCHK9/646-772 AC A3EXI9.1
#=GS R1A_BC512/780-897 AC P0C6F6.1
#=GS D9J202_9ALPC/778-877 AC D9J202.1
#=GS R9QTB2_SARS/690-818 AC R9QTB2.1
#=GS A0A125R5A3_9ALPC/465-584 AC A0A125R5A3.1
#=GS A0A096XNJ3_9ALPC/455-577 AC A0A096XNJ3.2
#=GS K4K1U5_9ALPC/475-591 AC K4K1U5.1
#=GS A0A125R5A4_9ALPC/465-584 AC A0A125R5A4.1
#=GS Q2QKN6_9BETC/719-851 AC Q2QKN6.1
#=GS R1AB_CVPPU/465-584 AC P0C6Y5.1
#=GS Q0Q485_SARS/691-819 AC Q0Q485.1
#=GS T2B9I2_MERS/717-853 AC T2B9I2.1
#=GS A0A023YA54_MERS/719-855 AC A0A023YA54.1
#=GS A0A3G8EYU2_9ALPC/471-586 AC A0A3G8EYU2.1
#=GS A0A0U1UZA8_9ALPC/776-893 AC A0A0U1UZA8.1
#=GS Q6UZF5_SARS/690-818 AC Q6UZF5.1
#=GS R1AB_BCHK4/714-847 AC P0C6W3.1
#=GS C6GHB6_9ALPC/768-879 AC C6GHB6.1
#=GS T2B9U0_MERS/717-853 AC T2B9U0.1
#=GS Q6R1L8_CVHNL/780-898 AC Q6R1L8.1
#=GS C6GHB5_9ALPC/465-584 AC C6GHB5.1
#=GS B1PHK1_9ALPC/774-891 AC B1PHK1.1
#=GS A0A1X9JQL5_9ALPC/454-574 AC A0A1X9JQL5.1
#=GS C6GHB5_9ALPC/768-879 AC C6GHB5.1
#=GS A0A1L2KGC1_9ALPC/475-592 AC A0A1L2KGC1.1
#=GS I1VWF3_CVH22/777-897 AC I1VWF3.1
#=GS A0A0U1UZC3_9ALPC/669-787 AC A0A0U1UZC3.1
#=GS A0A172B3C8_9ALPC/465-584 AC A0A172B3C8.1
#=GS S5Z1D1_9ALPC/473-590 AC S5Z1D1.1
#=GS A0A1L2KGC3_9ALPC/779-897 AC A0A1L2KGC3.1
#=GS B1PHK1_9ALPC/476-592 AC B1PHK1.1
#=GS A0A0U1WHG1_9ALPC/655-771 AC A0A0U1WHG1.1
#=GS A0A0U1WHG1_9ALPC/471-587 AC A0A0U1WHG1.1
#=GS R1AB_FIPV/768-879 AC Q98VG9.2
#=GS A0A172B201_9ALPC/465-584 AC A0A172B201.1
#=GS D9J203_9ALPC/465-584 AC D9J203.1
#=GS A0A125R5A4_9ALPC/768-879 AC A0A125R5A4.1
#=GS A8JNZ0_9ALPC/474-591 AC A8JNZ0.1
#=GS A8JNZ1_9ALPC/474-591 AC A8JNZ1.1
#=GS R1AB_CVH22/477-593 AC P0C6X1.1
#=GS Q6UZF1_SARS/690-818 AC Q6UZF1.1
#=GS D9J202_9ALPC/465-584 AC D9J202.1
#=GS R1AB_SARS2/690-818 AC P0DTD1.1
#=GS R1AB_BCHK5/715-851 AC P0C6W4.1
#=GS V9PIT1_9ALPC/465-584 AC V9PIT1.1
#=GS E0ZN59_BCHK9/646-772 AC E0ZN59.1
#=GS R1A_CVH22/477-593 AC P0C6U2.1
#=GS U5LR11_9BETC/723-859 AC U5LR11.1
#=GS I1VWF3_CVH22/477-593 AC I1VWF3.1
#=GS E0ZN35_BCHK9/646-772 AC E0ZN35.1
#=GS S5YAF0_9ALPC/779-896 AC S5YAF0.1
#=GS A8JNZ1_9ALPC/776-896 AC A8JNZ1.1
#=GS A0A059VJE6_9ALPC/778-895 AC A0A059VJE6.1
#=GS A0A0U1WHD1_9ALPC/774-891 AC A0A0U1WHD1.1
#=GS B7U2M9_9BETC/719-851 AC B7U2M9.1
#=GS Q6R1L9_CVHNL/780-898 AC Q6R1L9.1
#=GS A0A0U1WHL2_BCHK5/715-851 AC A0A0U1WHL2.1
#=GS R1AB_SARS/690-818 AC P0C6X7.1
#=GS R1A_CVPPU/768-879 AC P0C6V2.1
#=GS D9J203_9ALPC/775-877 AC D9J203.1
#=GS A0A172B3C8_9ALPC/797-876 AC A0A172B3C8.1
#=GS R1A_BC512/479-596 AC P0C6F6.1
#=GS A0A0U1WHD1_9ALPC/476-592 AC A0A0U1WHD1.1
#=GS I1VWF4_CVH22/777-897 AC I1VWF4.1
#=GS U5KNA9_9BETC/723-859 AC U5KNA9.1
#=GS A0A120I2U3_9ALPC/465-584 AC A0A120I2U3.1
#=GS A0A0K2RW65_9BETC/713-845 AC A0A0K2RW65.1
#=GS R1A_CVHN5/682-806 AC P0C6U5.1
#=GS A0A120I2U3_9ALPC/768-879 AC A0A120I2U3.1
#=GS A7BKB9_9BETC/719-851 AC A7BKB9.1
#=GS R1AB_BC512/479-596 AC P0C6W0.1
#=GS B1PHI6_9ALPC/775-892 AC B1PHI6.1
#=GS R1AB_CVHN5/683-806 AC P0C6X4.1
#=GS B1PHK0_9ALPC/774-891 AC B1PHK0.1
#=GS R1A_BCHK9/646-772 AC P0C6T6.1
#=GS A0A0U1WHG4_9ALPC/475-592 AC A0A0U1WHG4.1
#=GS A0A1B3Q5W8_9BETC/646-772 AC A0A1B3Q5W8.1
#=GS A0A172B201_9ALPC/797-876 AC A0A172B201.1
#=GS R1AB_BC512/780-897 AC P0C6W0.1
#=GS R1AB_BCHK9/646-772 AC P0C6W5.1
#=GS A0A0K1Z0N1_SARS/690-818 AC A0A0K1Z0N1.1
#=GS I1VWF4_CVH22/477-593 AC I1VWF4.1
#=GS R1A_CVPPU/465-584 AC P0C6V2.1
#=GS A0A0U1WHG4_9ALPC/772-889 AC A0A0U1WHG4.1
#=GS A3EXH3_BCHK9/646-772 AC A3EXH3.1
#=GS S5Z1D1_9ALPC/779-896 AC S5Z1D1.1
#=GS V9PIT1_9ALPC/768-879 AC V9PIT1.1
#=GS R1A_BCHK4/714-847 AC P0C6T4.1
#=GS B1PHI7_9ALPC/474-590 AC B1PHI7.1
#=GS R1A_SARS/690-818 AC P0C6U8.1
#=GS A0A0K2RVJ3_9BETC/713-845 AC A0A0K2RVJ3.1
#=GS R1A_SARS2/690-818 AC P0DTC1.1
#=GS Q0ZJK7_CVHK1/683-806 AC Q0ZJK7.1
#=GS B1PHI7_9ALPC/775-892 AC B1PHI7.1
B1PHI6_9ALPC/474-590 .............................v-DHFKVANKKFKR............AGNYVLFE...............NALACIVSAKVKGVK...QAG......LKKLLYAKAIVG.AT..VKV..TVSRIETAT......VKLTECKPSKF..VKKGNVAVINDIAFFHSDG-....VYRl.mSDSDEVYEDIAFTAEG-t........
Q6R1L9_CVHNL/476-592 .............................l-DVFKIGDVKFKR............LGDYVLTE...............NALVRLTTEVVRGVR...DAR......IKKAMFTKVVVG.PT..TEV..KFSVIELAT......VNLRLVDCAPV.vCPKGKIVVIAGQAFFYSGG-....FYRf.mVDSTTVLNDPVFT----gel......
S5YAF0_9ALPC/473-590 ..............................CDTVKVARHSYPR............LFDYVLLD...............NHLVKMVTQRITGKK...QAG......LTEATFADVILG.AT..TNV..TSDRTEACN......VGLVLCDYDVP.vLNTGYTAIIGGKAFFCSEG-....YYRf.mATPNVVLDEPVFRAAA-e........
A0A088DIE1_9BETC/685-814 .............................y-QQVQFAGTYVGAf.........eiHQTLLELG...............GAIYTRVQVAANSIQdlvLPS......TVSKKELTFVDG.HA..IDT..ELTSEEVTVlegiveQLDTDTNKIAG.dSIKGDLVTVNNCVFVRFGDG...nLSP...ATTDCQATKGVFKLKGG.........
A0A059VJE6_9ALPC/475-592 .............................c-DCLKVGGKTFNK............VGSYVLFD...............NALVKLVKAKVRGPR...QAG......VCEVRYTSLVIG.ST..TKV..VSKRVENAN......VNLVVVDEDVT.lNTTGRTVVVDGLAFFESDG-....FYRh.lADADVVIEHPVYKSAC-e........
C6GHB6_9ALPC/465-584 ..............................TQTITIAGVEAKCf.........vlGSKYLLFN...............NALVKLVSVKILGKR...QKG......LDRAFFATNLIG.AT..VNV..TPQRTEAAN......ISLNKADDVVT..PGEGHIVIVGDMAFYKSGEH....YFM..mASPDSVLTNNVFKAA--rv.......
A0A1L2KGC1_9ALPC/779-897 ..............................CKAVKTAGVTFKFy.........avEQPYVVFN...............GVLSRLARKKPADVD...CSF......DSRVGEFWAFID.AT..YAI.dNPKVADVEP......LELSEVDFVPP..TNGGRFVISDDFLWYNKDDL....YYP...-AGLSGVLPKAFTKNAG.........
R1A_CVH22/777-897 .............................v-STVKIGGLTFKTy.........afDKPYIVIR...............DIVCKVENKTEAEWIe.lFPH......NDRIKSFSTFES.AY..MPI.aDPTHFDIEE......VELLDAEFVEP..GCGGILAVIDEHVFYKKDGV....YYP...-SNGTNILPVAFTKAAG.........
A0A0K1YZY7_SARS/690-818 .............................i-DQVTIAGVKLRSl.........nlGEVFIAQS...............KGLYRQC---IRGKE...QLQll..mpLKAPKEVTFLEG.DS..HDT..VLTSEEVVLkngeleALETPVDSFTN.gAVVGTPVCVNGLMLLELKDKe..qYCA...LSPGLLATNNVFRLKGG.........
K4K1U5_9ALPC/773-890 .............................t-SVVKIGGKSF--............--TYYLFEkpk........maisGILHNVRVLKAKDCT...IAA......EDILVEMTVFDS.FE..IPI..QPSRVEVQQ......VEFEEAEFVQP..QAGGVLAVVNKHVFYNKGDY....YYP...-ANETHAVPVCYKRGSG.........
A0A125R5A3_9ALPC/768-879 .............................r-KNVKIGGIPFTTfk........tpSNSFIDMK...............DAIYSVV--------...EYG......-----EAFSFKT.AS..VPV.tNSGTVTNDDws..dpILLEPADYVEP..KDNGDVIVIAGYTFYKDEDD...hFYP...-YGSGMVVQKMYNKMGG.........
R1AB_CVH22/777-897 .............................v-STVKIGGLTFKTy.........afDKPYIVIR...............DIVCKVENKTEAEWIe.lFPH......NDRIKSFSTFES.AY..MPI.aDPTHFDIEE......VELLDAEFVEP..GCGGILAVIDEHVFYKKDGV....YYP...-SNGTNILPVAFTKAAG.........
A0A0U1UZA8_9ALPC/475-591 .............................v-DHFKIANKKFKR............AGDYILFE...............NALACLVSGKIKGVK...QAG......LKKLLYAKAIVG.AT..VKV..TVNRIESAT......VKLVECKPSNF..VKKGSAVVINNIAFFHSDG-....IYRl.mSDSDEVYEDIAFTAEG-v........
A0A0U1WHC6_9ALPC/476-592 .............................v-ETFKVAGETFSR............VGDCVLLE...............NAVVRLVSTKVKGLK...QSG......VKKATVATPIVG.AT..KKV..QSSRTEVGD......ITLVKTASAPL..VNQGVTVLIGGVAFFKSGG-....VYRl.mADADAVYEEPVYCQQA-s........
A0A3G8EYU2_9ALPC/655-771 .............................a-NIVKLAGVTF--............--THYAFT...............VPVIAFNGVLFPVKE...SKPpagvpvESSIKDFMSFKN.AD..VRV..KPTRVEREC......CELQEVDFVPP..KDGGILKVIDGYAFYNVGNN....YYP...-ASCDGIVSVMFNKKGG.........
A0A240FW17_9ALPC/432-553 ..........................kdig----SFLGVQF--............-RTFMNVNm............mnDCLFTVKNVTVNGVR...SMG......LTTMNVIDFFLG.KK..SSV..VVNEFEVAEww.nnsVSMVLCDAKP-..EGNGKGVVIAGQAFYNEGQ-....FYWpllKGTTEVAETLCFKQAGG.........
B1PHK0_9ALPC/476-592 ..............................VDTYKVVGETFKR............VGDYVLLG...............NAVAKLVTTKVKGVR...QAG......AKKVTFATPVIG.VA..KRV..TSTRTEIDS......VQLVACASTPL..VENGCTVIVDGIAFFKSGG-....VYRl.mADTDLVYETPVYCQQA-t........
R1A_BCHK5/715-851 ..............................HTTVSWAGSKLPSvvyngrdslvfpSGTYYCVSt............qgRSLQDQFDLVIPGDL...SKKqi..giLEPTPNST---T.VD..KKI..NTNVVEVVV......GQLEPTKEHSP.eLVVGDYVIISNKIFVRSVEDsetvFYP...LCTDGKIVPTLFRLKGG.........
A0A0U1UZC3_9ALPC/477-594 .............................a-NTVTIAGKAVRA............AFDYLLFD...............NAIVKLQSVKVSGLK...QAG......VKNALYASVVIG.PT..QNV..KTTRVEVVN......VKLTPITDKVP.fNREGYVALVDGVAFFVNDG-....YYRl.mADSDCVLEEPVFKAASG.........
A0A2Z4EVM4_9NIDO/637-763 .............................k-TTTKWAGCAVEGi..........yTNAHCFFSr............tgMLVEKQFKASSLGFI...FTP......RQAKAEIEVLEGdFD..VPV..ELCSEEVDEn....aGTLEEVFGASDlqIVRGQLSVLASKLFVRTEEG...lFYR...YVSSGGVLLKAFRLRGG.........
Q6R1L8_CVHNL/476-592 .............................l-DVFKIGDVKFKR............LGDYVLTE...............NALVRLTTEVVRGVR...DAR......IKKAMFTKVVVG.PT..TEV..KFSVIELAT......VNLRLVDCAPV.vCPKGKIVVIAGQAFFYSGG-....FYRf.mVDSTTVLNDPVFT----gel......
R1AB_FIPV/465-584 ..............................TQTITIAGVEAKCf.........vlGSKYLLFN...............NALVKLVSVKILGKR...QKG......LDSAFFATNLIG.AT..VNV..TPQRTESAY......ISLNKVDDVVT..PGGGHIVIIGDMAFYKSEE-....YYFm.mASPDSVLVNNVFKAA--rv.......
A0A0U1WHC6_9ALPC/774-891 ..............................CKTVVIGGLDF--............--AYYCFAkpa........ialgDTFVRVSRNALSAFN...RPV......EDGSSEAYTFDG.GA..IET..VCSRVQFDT......VVLESVQDIPV..PSDGYVAVVDGYTFFTDGTH....YFP...-TGLSRCHTTCFKRGGG.........
A8JNZ0_9ALPC/776-896 .........................ttvsv---LTICGISA--............--KYYAFDkpm........lcmhGITERVTSFDITSLG...KPI......LDGLSRCNVFAR.GS..NAV..VVDSVDHEL......LDLEECDFVEP..ASHGVLVVSDDYGFYSCETG....IYP...YASDGKVLPLRFRKKAG.........
R1AB_CVPPU/768-879 .............................r-NDIEIGGIPFSTfk........tpTNTFIEMT...............DAIYSVI--------...EQG......-----KALSFRD.AD..VPV.vDNGTISTADws..epILLEPAEYVKP..KNNGNVIVIAGYTFYKDEDE...hFYP...-YGFGKIVQRMYNKMGG.........
E0ZN51_BCHK9/646-772 ............................lt--SARWAGCKVEAv..........yTGTYHYFAkfgv.......vselQIRAKALGVLLTPRQ...QKM......EVEVLEGK----.ADapVEL..TSLELEELH......GTLEEVFGYSDlgLVKGSLVTMASKVFVRTDDG...vLYR...YVKSGGVLLKAFRLRGG.........
A0A1L2KGC3_9ALPC/475-592 .............................s-EVVTIGGQQFRA............IGSYILLN...............NAIVKIVTEKVKGVR...EHS......LRTAKYANAVIG.CT..VDV..TPTHIEPAV......VSLKLVDQAPP.iDKKGRIKVIGGQAFYFCNG-....VYRl.mATPTAVLQEPVFA----geas.....
A3EXI9_BCHK9/646-772 ............................lt--SARWAGCKVEAl..........yTGTYHYFAkcgv.......lsetQVCAKVLGVLLTPRQ...QKMev..evLEGTPDAP----.--..VDL..TNNELEEAH......GTLEEVFGYSDleLVKGSLVTMASKVFVRTDDG...vFYR...YVRSGGVLLKAFRLRGG.........
R1A_BC512/780-897 ............................ts--FIKVAGVAFKYc.........atCVPKIVIN...............GCYHTVTRLFAKDLQ...IPT......EDGVADFNTFNH.CV..FPV..NPTRIETDS......LELEEVDFVEP..GVDGKLVILDDYSFYSDGTN....YYP...-SDGKGVVASCFKKKGG.........
D9J202_9ALPC/778-877 ...gfttpigrdfldfgedvveifcggktr-------------............--------...............---------------...---......--------CFSG.AS..IPV.sVDKVVEDDVw...stIILEETEYQPP..KNGGVVVVIGGYTFYTTNHE...qFYP...-FGDSKVVQKLYNKAGG.........
R9QTB2_SARS/690-818 .............................i-DQVTIAGAKMRSl.........nlGEIFIAQS...............KGLYRQC---IRGKE...QLQll..mpLKAPKEVTFLDG.DS..HDT..VLTSEEVVLkngeleALETPVDSFTN.gAVVGTPVCVNGLMLLELKDKe..qYCA...LSPGLLATNNVFRLKGG.........
A0A125R5A3_9ALPC/465-584 ..............................TQTITIAGVEAKWf.........vlGSKYLLFN...............NALVKLVNVKILGKR...QKG......LDSAFFATNLIG.AT..VNV..TPQRTEAAN......ISLNKVDDVVT..PGEGHIVVVGDMAFYKSGEH....YFM..mASPDSVLTNNVFKAA--rv.......
A0A096XNJ3_9ALPC/455-577 ..................ilcidasdryfc----------CKDv..........tGTNLKLFK...............TLLVSWYESVINGAK...EAG......LTTAKYFTSVTG.KL..RAV..TVRRTEAGG.....dTVLEEVDDKVD.pPPSGICRLINDYAFYYGGG-....YYFp.lTASDQIIEGAVFKAAG-s........
K4K1U5_9ALPC/475-591 ..............................VNTVTFAGQSFKA............VGDYVLLN...............NAIVKFVSVKVKGLH...QDG......IKSTMYATTVVG.KT..AKV..KSRRIETCN......ANLSVVPDQAL..VKDGVTKIVGGRSFFCSGG-....CYRl.mSDVDTVIMSPVYQAV--ap.......
A0A125R5A4_9ALPC/465-584 ..............................TQTITIAGVEAKWf.........vlGSKYLLFN...............NALVKLVNVKILGKR...QKG......LDSAFFATNLIG.AT..VNV..TPQRTEAAN......ISLNKVDDVVT..PGEGHIVVVGDMAFYKSGEH....YFM..mASPDSVLTNNVFKAA--rv.......
Q2QKN6_9BETC/719-851 ...........................rvt---FIDGLSCFKI............GRRRICLSgrkiyevergllhssQLPLDVYDLTMPSQV...Q-K......AKQKPIYLKGSG.SD..FSL..ADSVVEVVT......TSLTPCGYSEP.pKFADKICIVDNVYMAKAGDK....YYPv.vVDDHVGLLDQAWRV---pca......
R1AB_CVPPU/465-584 .............................t-QIITIAGIEAKCf.........vlGAKYLLFN...............NALVKLVSVKILGKK...QKG......LECAFFATSLVG.AT..VNV..TPKRTETAT......ISLNKVDDVVA..PGEGYIVIVGDMAFYKSGE-....YYFm.mSSPNFVLTNNVFKA---vkv......
Q0Q485_SARS/691-819 .............................i-DQVTIAGTKVRSl.........nlGEVFIAQS...............KGLYRQC---VRGKE...QLQll..mpLKAPKEVTFLEG.DS..HDT..VLISEEVVLkngeleALETPVDSFTN.gAVVGTPVCVNGLMLLELKDKe..qYCA...LSPGLLATNNVFRLNGG.........
T2B9I2_MERS/717-853 ..............................HTKVSWAGSNISAviysgreslifpSGTYYCVTt............kaKSVQQDLDVILPGEF...SKKql..glLQPTDNST---T.VS..VTV..SSNMVETVV......GQLEQTNMHSP.dVIVGDYVIISEKLFVRSKEEdgfaFYP...ACTNGHAVPTLFRLKGG.........
A0A023YA54_MERS/719-855 ..............................HTKVSWAGAKVKAvvynsreslvfpSGTYYCVAa............raNAVQQEFSAVLPGEL...AKKql..glLEPVRHAT---T.VD..VQV..QNKVVDVVV......GQLEETNMHSP.dLIVGDYVVISDKLFVRCEEDgqtvFYP...MCTNGQAVPTLFRLKGG.........
A0A3G8EYU2_9ALPC/471-586 .............................i-EEFKVAGVVFKS............FGDYVLFD...............NALCRIVQAKIKGAK...QAG......LKEAKYVSLVSG.PA..THV..SVKRVEKSD......ANLTLFDNVVP..PSDGNAVIIGGLAFYTDGVH....YWF..mADSDTVLENPVFT----tgk......
A0A0U1UZA8_9ALPC/776-893 ............................kn--IISIGSIKCYHy.........gfVKPVLVIK...............DVFYRIHDAAVDTFN...VDV......EAGLNTVKTFSG.GE..NPI..TFSRVEVAS......VELEHAEYVKP..EANGHVSVINGHTFYTCGDY....YYP...-CDQNNCFSQCFKKVGG.........
Q6UZF5_SARS/690-818 .............................i-DQVTIAGAKLRSl.........nlGEVFIAQS...............KGLYRQC---IRGKE...QLQll..mpLKAPKEVTFLEG.DS..HDT..VLTSEEVVLkngeleALETPVDSFTN.gAIVGTPVCVNGLMLLEIKDKe..qYCA...LSPGLLATNNVFRLKGG.........
R1AB_BCHK4/714-847 ..............................HTNVSWAGTKLSAiiyegreallfnSGTYFCLSt............kaKTLQGQMNLVLPGDY...NKKtl..giLDPVPNAD---T.ID..VNA..NSTVVDVVH......GQLEPTNEHGP.sMIVGNYVLVSDKLFVRTEDE...eFYP...LCTNGKVVSTLFRLKGG.........
C6GHB6_9ALPC/768-879 .............................r-RDVEIGGIPFSTfk........tpSSSFIDMK...............DAIYSVV--------...EYG......-----EAFSFKT.AS..VPV..TNNGTVTADdw.sdpILLEPADYVEP..KDNGDVIVIAGYTFYKDEDD...hFYP...-YGSGMVVQKMYNKMGG.........
T2B9U0_MERS/717-853 ..............................HTKVSWAGSNISAviysgreslifpSGTYYCVTt............kaKSVQQDLDVILPGEF...SKKql..glLQPTDNST---T.VS..VTV..SSNMVETVV......GQLEQTNMHSP.dVIVGDYVIISEKLFVRSKEEdgfaFYP...ACTNGHAVPTLFRLKGG.........
Q6R1L8_CVHNL/780-898 ..............................CSVVHTAGVCI--............--KYYAVNvpy........vvisGFVSRVIRRERCDVT...FPC......VSCVTFFYEFLD.TC..FGV.sKPNAIDVEH......LELKETVFVEP..KDGGQFFVSDDYLWYVVDDI....YYP...-ASCNGVLPVAFTKLAG.........
C6GHB5_9ALPC/465-584 ..............................TQTITIAGVEAKCf.........vlGSKYLLFN...............NALVKLVSVKILGKR...QKG......LDRAFFATNLIG.AT..VNV..TPQRTEAAN......ISLNKADDVVT..PGEGHIVIVGDMAFYKSGEH....YFM..mASPDSVLTNNVFKAA--rv.......
B1PHK1_9ALPC/774-891 ..............................CKTVVIGGLEF--............--AYYCFAkpa........ialgDIFVRVSKNALSAFN...RPT......EAGAVDALVFEG.GD..IET..VCSRVQFDT......VALEPVQEVPV..PSDGYVAVVDGYTFFTDGTH....YFP...-TGLSRCYTTCFKRGGG.........
A0A1X9JQL5_9ALPC/454-574 .....................cieaseryf-----------HCkd........vtGTNLKVFK...............TLLVSWCEAAITGVK...EAG......LTTAKYFVSVTG.KV..CNV..VVKRTEAIS.....gVFLEEVDNTIT.pPSTGICRLINDYAFFYGGG-....YYFp.lTASNEVVDGAVFKAAG-s........
C6GHB5_9ALPC/768-879 .............................r-RDVEIGGIPFSTfk........tpSSSFIDMK...............DAIYSVV--------...EYG......-----EAFSFKT.AS..VPV..TNNGTVTADdw.sdpILLEPADYVEP..KDNGDVIVIAGYTFYKDEDD...hFYP...-YGSGMVVQKMYNKMGG.........
A0A1L2KGC1_9ALPC/475-592 .............................s-EVVTIGGQQFRA............IGSYILLN...............NAIVKIVTEKVKGVR...EHS......LRTAKYANAVIG.CT..VDV..TPTHIEPAV......VSLKLVDQAPP.iDKKGRIKVIGGQAFYFCNG-....VYRl.mATPTAVLQEPVFA----geas.....
I1VWF3_CVH22/777-897 .............................v-SIVKIGGKAFKKy.........afDKPYIVVC...............DIVCKVEHKTDADWV...ELMp....rNDRIKSFSTFEN.AY..LPI.aDPTHFDIEE......VELLDTEFVEP..GCGGILALIDDHVFYKKDDI....YYP...-SNGTKILPVAFTKAAG.........
A0A0U1UZC3_9ALPC/669-787 .............................r-QVVVLAGVKL--............--SYYAFEtpa........valnGVLHAVKRCSAKSLD...VPC......EEGAAEFNVFEG.GV..HLL..KPTAVELAS.....dMELLETDYVEP..CAGGVLRICDDYAWYMDGDR....FYP...-YGDNGVIPLCYKLGGG.........
A0A172B3C8_9ALPC/465-584 ..............................TQTVEFFGVTAKFl.........llGCKYILFE...............NALFKLETLKLSGKR...ESG......LKDAVFASAIVG.ST..IEV..KPSRFEKST......ANLVVVEDVVM..PGEGHAVVVGDMAFYRSGD-....YYFm.mTSPTSVLTTTVFKAE--ka.......
S5Z1D1_9ALPC/473-590 ..............................CDTVKVARHSYPR............LFDYVLLD...............NHLVKMVTQRITGKK...QAG......LTEATFADVILG.AT..TNV..TSDRTEACN......VGLVLCDYDVP.vLNTGYTAIIGGKAFFCSEG-....YYRf.mATPNVVLDEPVFRAAA-e........
A0A1L2KGC3_9ALPC/779-897 ..............................CKAVKTAGVTFKFy.........avEQPYVVFN...............GVLSRLARKKPADVD...CSF......DSRVGEFWAFID.AT..YAI.dNPKVADVEP......LELSEVDFVPP..TNGGRFVISDDFLWYNKDDL....YYP...-AGLSGVLPKAFTKNAG.........
B1PHK1_9ALPC/476-592 ..............................VDTYKVVGETFKR............VGDYVLLG...............NAVAKLVTTKVKGVR...QAG......AKKVTFATPVIG.VA..KRV..TSTRTEIDS......VQLVACASTPL..VENGCTVIVDGIAFFKSGG-....VYRl.mADTDLVYETPVYCQQA-t........
A0A0U1WHG1_9ALPC/655-771 .............................s-DVVKIACMNF--............--TYYAFN...............KPMVAVNGTLCPVEL...VEPpsdvskEALVTDFMVFKS.PD..THV..KPIRIETES......CELHEVDFVTP..RDGGVVKIIDGYAFYESNGN....YYP...-SSVDGVKNVTYRKKGG.........
A0A0U1WHG1_9ALPC/471-587 .............................i-EEFKVAGVAFKR............LGDYVLFD...............NALCQLASVKLKGFK...QDG......LKTATYVSTVYG.PS..KRV..KVKRVEKCD......ANLVLCDSAPL..VDEGYACVIQGQAFYTNGT-....YYWf.mTDHTSVLESPVFKKD--ti.......
R1AB_FIPV/768-879 .............................r-KDIEIGGIPFSTfk........tpSSSFIDMK...............DAIYSVV--------...EYG......-----EALSFKT.AS..VPV..TNSGIITTDdw.sdpILLEPADYVEP..KDNGDVIVIAGYTFYKDEDD...hFYP...-YGSGMVVQKMYNKMGG.........
A0A172B201_9ALPC/465-584 ..............................TQTVEFFGVTAKFl.........llGCKYILFE...............NALFKLETLKLSGKR...ESG......LKDAVFASAIVG.ST..IEV..KPSRFEKST......ANLVVVEDVVM..PGEGHAVVVGDMAFYRSGD-....YYFm.mTSPTSVLTTTVFKAE--ka.......
D9J203_9ALPC/465-584 ..............................TQTVEVVGITCKCv.........vlGCKYLLFD...............NALVMLKDLKLKGKR...EAG......LNTATFASAIIG.GT..AEV..NPTRFEYST......ANLTLVNDVVQ..PGPGYAVVIGGMAFYCTGD-....YYFm.mSSPTSVITTSVFKAS--if.......
A0A125R5A4_9ALPC/768-879 .............................r-KNVKIGGIPFTTfk........tpSNSFIDMK...............DAIYSVV--------...EYG......-----EAFSFKT.AS..VPV.tNSGTVTNDDws..dpILLEPADYVEP..KDNGDVIVIAGYTFYKDEDD...hFYP...-YGSGMVVQKMYNKMGG.........
A8JNZ0_9ALPC/474-591 ..............................CDDIVVFGVKCKA............VGDYIIFN...............NSVVKTVKAKIKGVK...EAG......LKTMTYTQCLLG.PT..KPV..KVKRVERSV......AQLKVVDTAVP.lKQEGECLVVGGRAMFRSDG-....YYRf.mADADVVLESPVFTAG--sq.......
A8JNZ1_9ALPC/474-591 ..............................CDDIVVFGVKCKA............VGDYIIFN...............NSVVKTVKAKIKGVK...EAG......LKTMTYTQCLLG.PT..KPV..KVKRVERSV......AQLKVVDTAVP.lKQEGECLVVGGRAMFRSDG-....YYRf.mADADVVLESPVFTAG--sq.......
R1AB_CVH22/477-593 .............................v-ETCTIAGKAFDK............VFDYVLLD...............NALVKLVTTKLKGVR...ERG......LNKVKYATVVVG.ST..EEV..KSSRVERST......AVLTIANNYSK.lFDEGYTVVIGDVAYFVSDG-....YFRl.mASPNSVLTTAVYKP---lf.......
Q6UZF1_SARS/690-818 .............................i-DQVTIAGAKLRSl.........nlGEVFIAQS...............KGLYRQC---IRGKE...QLQll..mpLKAPKEVTFLEG.DS..HDT..VLTSEEVVLkngeleALETPVDSFTN.gAIVGTPVCVNGLMLLEIKDKe..qYCA...LSPGLLATNNVFRLKGG.........
D9J202_9ALPC/465-584 ..............................TQTVEVVGITCKCv.........vlGCKYLLFD...............NALVMLKDLKLKGKR...EAG......LNTATFASAIIG.GT..AEV..NPTRFEYST......ANLTLVNDVVQ..PGPGYAVVIGGMAFYCTGD-....YYFm.mSSPTSVITTSVFKAS--if.......
R1AB_SARS2/690-818 .............................a-DSIIIGGAKLKAl.........nlGETFVTHS...............KGLYRKC---VKSRE...ETGll..mpLKAPKEIIFLEG.ET..LPT..EVLTEEVVLktgdlqPLEQPTSEAVE.aPLVGTPVCINGLMLLEIKDTe..kYCA...LAPNMMVTNNTFTLKGG.........
R1AB_BCHK5/715-851 ..............................HTTVSWAGSKLPSvvyngrdslvfpSGTYYCVSt............qgRSLQDQFDLVIPGDL...SKKqi..giLEPTPNST---T.VD..KKI..NTNVVEVVV......GQLEPTKEHSP.eLVVGDYVIISNKIFVRSVEDsetvFYP...LCTDGKIVPTLFRLKGG.........
V9PIT1_9ALPC/465-584 ..............................TQTITIAGVEAKCf.........vlGSKYLLFN...............NALVKLVSVKILGKR...QKG......LDSAFFATNLIG.AT..VNV..TPQRTESAY......ISLNKVDDVVT..PGGGHIVIIGDMAFYKSEE-....YYFm.mASPDSVLVNNVFKAA--rv.......
E0ZN59_BCHK9/646-772 .............................l-TSVKWAGCKVEAl..........yTGTYYYFSqngl.......ltevQVCAKRLGLLLTPRQ...QKM......EVEVLDGD--YD.AP..VTL..TDLELEEST......GVLEEVFGASDvkLVQGTLVSLASKLFVRTADG...lFYR...YVKSGGVLSKAFRLRGG.........
R1A_CVH22/477-593 .............................v-ETCTIAGKAFDK............VFDYVLLD...............NALVKLVTTKLKGVR...ERG......LNKVKYATVVVG.ST..EEV..KSSRVERST......AVLTIANNYSK.lFDEGYTVVIGDVAYFVSDG-....YFRl.mASPNSVLTTAVYKP---lf.......
U5LR11_9BETC/723-859 ..............................HKKVSWAGSKVHAviyegkdalvfsSGTYHCVTa............pgSVVGAHLEATIPGEV...VKKql..smLTATNYST---T.VD..VRP..KTRNVELVY......GQLETTNMHSP.dVVVGDYVIVSDKVFVRSEEDgrlaFYP...MCTNGKAVPCMFTLKGG.........
I1VWF3_CVH22/477-593 .............................v-ETSTIAGKSFDK............VFDYVLLD...............NALVKLVTIKLKGVR...ASG......LKTVKYATAVVG.ST..EEV..KSSRVERST......AVLTIANNYPK.lSDEGYTAVIGDVAYFVSDG-....YFRl.mASPNSVLTTAVYKP---lf.......
E0ZN35_BCHK9/646-772 ............................lt--SARWAGCKVEAv..........yTGTYHYFAkfgv.......vselQIRAKALGVLLTPRQ...QKM......EVEVLEGK----.ADapVEL..TSLELEELH......GTLEEVFGYSDlgLVKGSLVTMASKVFVRTDDG...vLYR...YVKSGGVLLKAFRLRGG.........
S5YAF0_9ALPC/779-896 ............................sa--AIHIAGVKF--............--IHYATTvpq........laynGCLYALKKTYAATVG...LQT......EEGVDGFYAFDH.CQ..LPV..TPRLLQVED......VNLEEADFKPP..VGGGCVAVINGYSFYVEGDS....YYP...-TDCSAIHSLRFRKLGG.........
A8JNZ1_9ALPC/776-896 .........................ttvsv---LTICGISA--............--KYYAFDkpm........lcmhGITERVTSFDITSLG...KPI......LDGLSRCNVFAR.GS..NAV..VVDSVDHEL......LDLEECDFVEP..ASHGVLVVSDDYGFYSCETG....IYP...YASDGKVLPLRFRKKAG.........
A0A059VJE6_9ALPC/778-895 ............................ve--NLVLAGVSF--............--KYYATSvpk........ivlgCCFHSVKSVLASAFQ...IPV......QAGVEKFKVFLN.CV..HPV..VPRVIETSF......VELEETTFKPP..ALNGSIAIVDGFAFYYDGTL....YYP...-TDGNSVVPICFKKKGG.........
A0A0U1WHD1_9ALPC/774-891 ..............................CKTVVIGGLDF--............--AYYCFAkpa........ialgDTFVRVSRNALSAFN...RPV......EDGSSEAYTFDG.GA..IET..VCSRVQFDT......VVLESVQDIPV..PSDGYVAVVDGYTFFTDGTH....YFP...-TGLSRCHTTCFKRGGG.........
B7U2M9_9BETC/719-851 ...........................rvt---FIDGLSCFKI............GRRRICLSgskiyevergllhssQLPLDVYDLTMPSQV...Q-K......AKQKPIYLKGSG.SD..FSL..ADSVVEVVT......TSLTPCGYSEP.pKVADKICIVDNVYMAKAGDK....YYPv.vVDGHVGLLDQAWRV---pca......
Q6R1L9_CVHNL/780-898 ..............................CSVVHTAGVCI--............--KYYAVNvpy........vvisGFVSRVIRRERCDVT...FPC......VSCVTFFYEFLD.TC..FGV.sKPNAIDVEH......LELKETVFVEP..KDGGQFFVSDDYLWYVVDDI....YYP...-ASCNGVLPVAFTKLAG.........
A0A0U1WHL2_BCHK5/715-851 ..............................HTTVSWAGSKLPSvvyngrdslvfpSGTYYCVSt............qgRSLQDQFDLVIPGDL...SKKqi..giLEPTPNST---T.VD..KKI..NTNVVEVVV......GQLEPTKEHSP.eLVVGDYVIISNKIFVRSVEDsetvFYP...LCTDGKIVPTLFRLKGG.........
R1AB_SARS/690-818 .............................i-DQVTIAGAKLRSl.........nlGEVFIAQS...............KGLYRQC---IRGKE...QLQll..mpLKAPKEVTFLEG.DS..HDT..VLTSEEVVLkngeleALETPVDSFTN.gAIVGTPVCVNGLMLLEIKDKe..qYCA...LSPGLLATNNVFRLKGG.........
R1A_CVPPU/768-879 .............................r-NDIEIGGIPFSTfk........tpTNTFIEMT...............DAIYSVI--------...EQG......-----KALSFRD.AD..VPV.vDNGTISTADws..epILLEPAEYVKP..KNNGNVIVIAGYTFYKDEDE...hFYP...-YGFGKIVQRMYNKMGG.........
D9J203_9ALPC/775-877 tlsgfttpigrdfldfgedvveifcggktr-------------............--------...............---------------...---......--------CFSG.AS..IPV.sVDKVVEDDVw...stIILEETEYQPP..KNGGVVVVIGGYTFYTTNHE...qFYP...-FGDSKVVQKLYNKAGG.........
A0A172B3C8_9ALPC/797-876 .......................lfddepv-------------............--------...............---------------...---......-------RCFTG.AT..VPV..NVSDFEDDVr...gdVVLEECEYQPP..RDEGIVVNLGGYTFYTTDNE...kFYP...-FGDCKVVPKLYNKAGG.........
R1A_BC512/479-596 ..............................CDALVVAGKSFAK............IGDYVLLP...............SALVRLVSSKVKGKA...QSG......IKQLQFATVVLG.DT..HKV..ESDRVEFSS......VNLKMVDEEFP.lNPVGHTVAVGNQAFFCSDG-....LYRf.mADRDLVITSPIFKPE--le.......
A0A0U1WHD1_9ALPC/476-592 .............................v-ETFKVAGETFSR............VGDCVLLE...............NAVVRLVSTKVKGLK...QSG......VKKATVATPIVG.AT..KKV..QSSRTEVGD......LTLVKTASVPL..VNQGVTVLIGGVAFFKSGG-....VYRl.mADADAVYEEPVYCQQA-s........
I1VWF4_CVH22/777-897 .............................v-SIVKIGGKAFKKy.........afDKPYIVVC...............DIVCKVEHKTDADWV...ELMp....rNDRIKSFSTFEN.AY..LPI.aDPTHFDIEE......VELLDTEFVEP..GCGGILALIDDHVFYKKDDI....YYP...-SNGTKILPVAFTKAAG.........
U5KNA9_9BETC/723-859 ..............................HKKVSWAGSKVHAviyegkdalvfsSGTYHCVTa............pgSVVGAHLEATIPGEV...VKKql..smLTATNYST---T.VD..VRP..KTRNVELVY......GQLETTNMHSP.dVVVGDYVIVSDKVFVRSEEDgrlaFYP...MCTNGKAVPCMFTLKGG.........
A0A120I2U3_9ALPC/465-584 .............................t-QIITIAGIEAKCf.........vlGAKYLLFN...............NALVKLVSVKILGKK...QKG......LECAFFATSLVG.AT..ANV..TPKRTETAT......ISLNKVDDVVA..PGEGYIVIVGDMAFYKSGE-....YYFm.mSSPNSVLTNNVFKA---vkv......
A0A0K2RW65_9BETC/713-845 ............................rv--TFIKGLSVFKI............GRKRICFSgsnv.......yeleRGLLDLSHLPSSVYD...LTMpskiqkANQKPIYLKGVG.FD..FSL..SDDVVEVVT......ASIIPCGYSKP.pKIAEKICVVDNVYMAKAGDK....YYPv.vVDKQAGLLDQAWRIP--ca.......
R1A_CVHN5/682-806 ........llecvtvdvlkdmpvlktingl-------------............----VCIV..............gNKFYNVSTGLIPGFV...LPC......NAQEQQIYFFEG.VA..ESVivEDDVIENVK......SSLSSYEYCQP.pKSVEKICIIDNMYMGKCGDK....FFP..iVMNDKNI----------clldhawrf
A0A120I2U3_9ALPC/768-879 .............................r-NDIEIGGIPFSTfk........tpTNTFIEMT...............DAIYSVV--------...EQG......-----EALSFRD.AD..VPV.vDNGTIATADws..epILLEPAEYVKP..KNNGNVIVIAGYTFYKDEDE...hFYP...-YGFGKIVQRMYNKMGG.........
A7BKB9_9BETC/719-851 ...........................rvt---FIDGLSCFKI............GRRRICLSgskiyevergllhssQLPLDVYDLTMPSQV...QK-......TKQKPIYLKGSG.SD..FSL..ADSVVEVVT......TSLTPCGYSEP.pKVADKICIVDNVYMAKAGDK....YYPv.vVDGHVGLLDQAWRV---pca......
R1AB_BC512/479-596 ..............................CDALVVAGKSFAK............IGDYVLLP...............SALVRLVSSKVKGKA...QSG......IKQLQFATVVLG.DT..HKV..ESDRVEFSS......VNLKMVDEEFP.lNPVGHTVAVGNQAFFCSDG-....LYRf.mADRDLVITSPIFKPE--le.......
B1PHI6_9ALPC/775-892 ............................kr--VISIGSVTCFHy.........gfV------Kpml.........vikDVFYCIEDAIVDTFN...VAT......EAGLNTVKTFIG.GD..SSI..TVSRVEIAS......VELEAAQYVKP..EDNGYVSVIDGHTFYTCGD-....YYH...PCDQQNCFSQCFKKVGG.........
R1AB_CVHN5/683-806 .........lecvtvdvlkdmpvlktingl-------------............----VCIV..............gNKFYNVSTGLIPGFV...LPC......NAQEQQIYFFEG.VA..ESVivEDDVIENVK......SSLSSYEYCQP.pKSVEKICIIDNMYMGKCGDK....FFP..iVMNDKNI----------clldhawrf
B1PHK0_9ALPC/774-891 ..............................CKTVVIGGLEF--............--AYYCFAkpa........ialgDIFVRVSKNALSAFN...RPT......EAGAVDALVFEG.GD..IET..VCSRVQFDT......VALEPVQEVPV..PSDGYVAVVDGYTFFTDGTH....YFP...-TGLSRCYTTCFKRGGG.........
R1A_BCHK9/646-772 .............................l-TSVKWAGCKVDAl..........yTGTYYYFSrkgv.......ltevQLCAKRLGLLLTPKQ...QKMev..evLDGDFDAP----.--..VTL..TDLELEECT......GVLEEVFGASDvkLVKGTLVSLASKLFVRTEDG...fLYR...YVKSGGVLGKAFRLRGG.........
A0A0U1WHG4_9ALPC/475-592 .............................v-NSVKIAGRSFKS............IGSYVLFD...............NAIIKFVAVKVKGLH...QAG......IKSTEYATSIIG.KT..TKV..NSKRTESAD......VNLVLVNDKQP.lLKDGVTKIIGGKSFFYSGG-....VYRl.mSDNNSVLDEPVFQEKV-s........
A0A1B3Q5W8_9BETC/646-772 .............................a-TTVKWAGCKIDGf..........yNGDYHFFSakgv.......ltevQVCAKTLGAMLTPRQ...QRMev..evLDGKYDAP----.--..VAI..TVPELEELN......GTLEEVFGFDDltLVRGSLVALASKVFVRTDDG...lLFR...YVKSGGVFLKAFRLRGG.........
A0A172B201_9ALPC/797-876 .......................lfddepv-------------............--------...............---------------...---......-------RCFTG.AT..VPV..NVSDFEDDVr...gdVVLEECEYQPP..RDEGIVVNLGGYTFYTTDNE...kFYP...-FGDCKVVPKLYNKAGG.........
R1AB_BC512/780-897 ............................ts--FIKVAGVAFKYc.........atCVPKIVIN...............GCYHTVTRLFAKDLQ...IPT......EDGVADFNTFNH.CV..FPV..NPTRIETDS......LELEEVDFVEP..GVDGKLVILDDYSFYSDGTN....YYP...-SDGKGVVASCFKKKGG.........
R1AB_BCHK9/646-772 .............................l-TSVKWAGCKVDAl..........yTGTYYYFSrkgv.......ltevQLCAKRLGLLLTPKQ...QKMev..evLDGDFDAP----.--..VTL..TDLELEECT......GVLEEVFGASDvkLVKGTLVSLASKLFVRTEDG...fLYR...YVKSGGVLGKAFRLRGG.........
A0A0K1Z0N1_SARS/690-818 .............................i-DQVTIAGVKLRSl.........nlGEVFIAQS...............KGLYRQC---IRGKE...QLQll..mpLKAPKEVTFLEG.DS..HDT..VLTSEEVVLkngeleALETPVDSFTN.gAVVGTPVCVNGLMLLELKDKe..qYCA...LSPGLLATNNVFRLKGG.........
I1VWF4_CVH22/477-593 .............................v-ETSTIAGKSFDK............VFDYVLLD...............NALVKLVTIKLKGVR...ASG......LKTVKYATAVVG.ST..EEV..KSSRVERST......AVLTIANNYPK.lSDEGYTAVIGDVAYFVSDG-....YFRl.mASPNSVLTTAVYKP---lf.......
R1A_CVPPU/465-584 .............................t-QIITIAGIEAKCf.........vlGAKYLLFN...............NALVKLVSVKILGKK...QKG......LECAFFATSLVG.AT..VNV..TPKRTETAT......ISLNKVDDVVA..PGEGYIVIVGDMAFYKSGE-....YYFm.mSSPNFVLTNNVFKA---vkv......
A0A0U1WHG4_9ALPC/772-889 ..............................TKTIKIGSQAF--............--TYYAFEvpk........vllsGALHSVRTVKAKELN...LSV......QDVIVEFNVFDG.AT..VEV..TPNRVEKEE......ISLEEVEFIPP..EGNGSIAVVDGYSFYSCGDL....YYP...-SNENAVVPLCFKRSGG.........
A3EXH3_BCHK9/646-772 .............................l-TSAKWAGCKVEAl..........yTGTYYYFSrngl.......ptevQVCAKRLGLLLTPRQ...QKMev..evLDGEYDAP----.--..VTL..TDLELEEST......GVLEEVFGASDvkLVQGTLVSLASKLFVRTADG...lFYR...YVKSGGVLSKAFRLRGG.........
S5Z1D1_9ALPC/779-896 ............................sa--AIHIAGVKF--............--IHYATTvpq........laynGCLYALKKTYAATVG...LQT......EEGVDGFYAFDH.CQ..LPV..TPRLLQVED......VNLEEADFKPP..VGGGCVAVINGYSFYVEGDS....YYP...-TDCSAIHSLRFRKLGG.........
V9PIT1_9ALPC/768-879 .............................r-KDIEIGGIPFSTfk........tpSSSFIDMK...............DAIYSVV--------...EYG......-----EALSFKT.AS..VPV..TNSGIITTDdw.sdpILLEPADYVEP..KDNGDVIVIAGYTFYKDEDD...hFYP...-YGSGMVVQKMYNKMGG.........
R1A_BCHK4/714-847 ..............................HTNVSWAGTKLSAiiyegreallfnSGTYFCLSt............kaKTLQGQMNLVLPGDY...NKKtl..giLDPVPNAD---T.ID..VNA..NSTVVDVVH......GQLEPTNEHGP.sMIVGNYVLVSDKLFVRTEDE...eFYP...LCTNGKVVSTLFRLKGG.........
B1PHI7_9ALPC/474-590 .............................v-DHFKVANKKFKR............AGNYVLFE...............NALACIVSAKVKGVK...QAG......LKKLLYAKAIVG.AT..VKV..TVSRIETAT......VKLTECKPSKF..VKKGNVAVINDIAFFHSDG-....VYRl.mSDSDEVYEDIAFTAEG-t........
R1A_SARS/690-818 .............................i-DQVTIAGAKLRSl.........nlGEVFIAQS...............KGLYRQC---IRGKE...QLQll..mpLKAPKEVTFLEG.DS..HDT..VLTSEEVVLkngeleALETPVDSFTN.gAIVGTPVCVNGLMLLEIKDKe..qYCA...LSPGLLATNNVFRLKGG.........
A0A0K2RVJ3_9BETC/713-845 ............................rv--TFIKGLSVFKI............GRKRICFSgsnv.......yeleRGLLDLSHLPSSVYD...LTMpskiqkANQKPIYLKGVG.FD..FSL..SDDVVEVVT......ASIIPCGYSKP.pKIAEKICVVDNVYMAKAGDK....YYPv.vVDKQAGLLDQAWRIP--ca.......
R1A_SARS2/690-818 .............................a-DSIIIGGAKLKAl.........nlGETFVTHS...............KGLYRKC---VKSRE...ETGll..mpLKAPKEIIFLEG.ET..LPT..EVLTEEVVLktgdlqPLEQPTSEAVE.aPLVGTPVCINGLMLLEIKDTe..kYCA...LAPNMMVTNNTFTLKGG.........
Q0ZJK7_CVHK1/683-806 .........lecvtvdvlkdmpvlktingl-------------............----VCIV..............gNKFYNVSTGLIPGFV...LPC......NAQEQQIYFFEG.VA..ESVivEDDVIENVK......SSLSSYEYCQP.pKSVEKICIIDNMYMGKCGDK....FFP..iVMNDKNI----------clldhawrf
B1PHI7_9ALPC/775-892 ............................kr--VISIGSVTCFHy.........gfV------Kpml.........vikDVFYCIEDAIVDTFN...VAT......EAGLNTVKTFIG.GD..SSI..TVSRVEIAS......VELEAAQYVKP..EDNGYVSVIDGHTFYTCGD-....YYH...PCDQQNCFSQCFKKVGG.........
#=GC seq_cons .............................h.pslpluGhphpt............stsYlhhs...............sslhclhphhltuhp...pts......hptsh.spsh.G.ss..hsV..sssplEsss......spLp.sc.sss..hssGphlllsshsFacss-.....aY....hssssslhsssF+htu..........
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