#=GF ID   Colicin
#=GF AC   PF01024.23
#=GF DE   Colicin pore forming domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Bateman A
#=GF GA   23.40 23.40;
#=GF TC   24.40 26.40;
#=GF NC   22.20 19.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   1373773
#=GF RT   Refined structure of the pore-forming domain of colicin A at 2.4
#=GF RT   A resolution. 
#=GF RA   Parker MW, Postma JP, Pattus F, Tucker AD, Tsernoglou D; 
#=GF RL   J Mol Biol 1992;224:639-657.
#=GF DR   INTERPRO; IPR000293;
#=GF DR   SCOP; 1col; fa;
#=GF DR   HOMSTRAD; Colicin;
#=GF DR   TC; 1.C.1;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF SQ   24
#=GS A0A014PWS1_9GAMM/128-313  AC A0A014PWS1.1
#=GS A0A4P7L2K9_9GAMM/241-426  AC A0A4P7L2K9.1
#=GS A0A370R0V1_9GAMM/17-108   AC A0A370R0V1.1
#=GS A0A4P7JC92_9ENTR/172-356  AC A0A4P7JC92.1
#=GS A0A8J3GJ04_9HYPH/175-369  AC A0A8J3GJ04.1
#=GS M1SHS7_MORMO/1-116        AC M1SHS7.1
#=GS A0A6M8U9Q6_9GAMM/7-207    AC A0A6M8U9Q6.1
#=GS A0A0Q4MWP4_9GAMM/5-184    AC A0A0Q4MWP4.1
#=GS A0A8H9Z0Y0_9PSED/183-366  AC A0A8H9Z0Y0.1
#=GS C0AW44_9GAMM/1-81         AC C0AW44.1
#=GS A0A380QRI8_YERRU/265-451  AC A0A380QRI8.1
#=GS B1VJ71_PROMH/284-482      AC B1VJ71.1
#=GS A0A3N1J581_9ENTR/285-476  AC A0A3N1J581.1
#=GS B4F067_PROMH/378-561      AC B4F067.1
#=GS B2VE54_ERWT9/348-530      AC B2VE54.1
#=GS C0AY95_9GAMM/234-421      AC C0AY95.1
#=GS A0A2Z2EQH1_9CAUD/175-370  AC A0A2Z2EQH1.1
#=GS A0A0Q4MTM7_9GAMM/75-260   AC A0A0Q4MTM7.1
#=GS A0A7X6IK78_9PSED/200-392  AC A0A7X6IK78.1
#=GS A0A427K289_9GAMM/111-294  AC A0A427K289.1
#=GS A0A3N1IY76_9ENTR/251-434  AC A0A3N1IY76.1
#=GS D2TV62_CITRI/314-510      AC D2TV62.1
#=GS A0A328TKF4_9GAMM/1-84     AC A0A328TKF4.1
#=GS Q9I4Y4_PSEAE/310-494      AC Q9I4Y4.1
A0A014PWS1_9GAMM/128-313             .............trkklpp-------.D.SEIQEAIKFTTD....FYSVLTDKFSERFANHARNFANKA...K...GKRLRNATDAYNAFLKnYKDKNVMKFSKSDRMAMLNALNSVE.YSSMARNLKRFSVAMGYYGTIADIVDVVGEIRTALQTNQWRSVFVKLET.....I.....A.AGKVA....VVATGF...A.F......S..L.........IIGTP..I..GIIGYA..V....IMAVVGAMINDSLINEIN--ss..................................
A0A4P7L2K9_9GAMM/241-426             ............kqnldnek-------.Q.NEIKDAVKFTAD....FYKEVTSKYGEQSAKIAKELAEAA...K...GKQIRNAEQALKSFDK.YKESLNKKFGVKDREAIAKALESLK.RDEIAKNLKKFSKAFGLTSSFIDFHDLLQELKKSIETNNWQPFFIKTES.....L.....V.AGKAA....VAITAF...S.F......S..I.........ILGSP..I..GALGYA..L....IIAVVGALINDELIEKANKL....................................
A0A370R0V1_9GAMM/17-108              .............vvisviy-------.-.------------....------------------------...-...----------------.-------------------------.------------EAFGLVGTAIDINDMRVAVTKGVRTGDWNDAFRTAER.....L.....A.TSGLA....SA--AV...A.F......A..A.........LTATL..M..GIVGYA..L....IMAFTSALIDDALMDRINK-f...................................
A0A4P7JC92_9ENTR/172-356             .................del---KSKD.A.EQIKDALKVTAD....FYNQLTGKLGEHSSKVAKELAEAS...R...GKQINGVDDALKSFDK.FRNNLNKKYSLKDRQAISHALESIN.RAEMAKSFGIYSKAFGFVSKSLDRLDVAVELQKALTTDNWRPFFVKMES.....L.....A.AGRVA....SAVTAW...T.F......A..L.........MVGTP..V..GILGFA..I....IMAAMSALVNDSLMEDINKL....................................
A0A8J3GJ04_9HYPH/175-369             ......nesqasvidttsgi-------.-.---------ITD....SGKTLSGKLGDKYNTLAKEAADNIknfQ...GKKLRSFNDAMASINE.LANNPKMKLSQADKTVVSNALKQMD.LSALADRFKGLEKAFTWGDRLLKAEKIRDGVVTGVTTGDWQKLAFEVEA.....M....yL.SGVAG....AVALGI...T.T......A..M.........ISTVA..V..AL----..-....--------------------slpavavsaltvvsvigisiltsyidadkakaln..
M1SHS7_MORMO/1-116                   .................mns-------.-.------------....------------------------...-...----------------.-----------EDRRAIVAALESIK.SAETAKNFTKFSKGMGVLSHAINAFDWVGELIKSVKTDNWRPFFVKTEV.....I.....A.AGNAA....TVVVAF...I.F......S..V.........LLGNP..V..GLIGYG..L....IMAGTGVLIDDELAEKAN--lf..................................
A0A6M8U9Q6_9GAMM/7-207               .................qkqAEEKASNgK.DALNKASTLVAD....MGEKVGAYLGQKYKFIANEIASDIknfQ...GKRIRSFNEAMKSLNK.VTQNPEMKINRNDRQAIVNAWKHIN.AADMANKLGNLSKAFKVADVVIKVEKVRQKSIEGYETGNWGPLLLEVESwvvsgI.....V.AGVALa.lfSSMVSL...F.T......VagT.........FPATA..I..MILGI-..L....SISWMASYIDEKLVDKIN--hq..................................
A0A0Q4MWP4_9GAMM/5-184               ..............skspgk-------.-.------------....---DISKAIENKYNEIAKEIAEDI...RnfqGKTIRSYDDAMKSLQK.IIENPSMKIKSSDKDAIVNALKGFD.AKDMADKVGKLGRSFNVAGLILKVDTVRQKFIEGIKTGNWGPLVLEVES.....W.....VlSGIAS....TIALGVfsaA.LapwllaA..G.........MTTTA..V..TVAGI-..I....VVAFLASLIDAKVAEKINN-e...................................
A0A8H9Z0Y0_9PSED/183-366             ................negl-----TE.R.EAYTSAIKMTAD....FYKEIGAKYGAQQAAIAKELEAAS...K...GKPMKNVDQAMAAFSK.NKAILDANLSTSNREAIANALKAVD.RSKAAKQLVAFGKAFGIVGITMDMYDLLASLQTSIKTNNWRPFFVKAES.....M.....L.LAKEA....GVLTAW...A.F......S..I.........MLGTP..L..GIIGYA..V....IMAAVSALVNEALVNKVVN-t...................................
C0AW44_9GAMM/1-81                    ....................-------.-.------MKFTIL....FYEKVTQEFGKKAAQLSKELAEQS...K...GKTIRNVEDALRTYEK.YGQNINNKINAKDRAAIIKALESIDaKQLL---------------------------------------------.....-.....-.-----....------...-.-......-..-.........-----..-..------..-....--------------------wnsf................................
A0A380QRI8_YERRU/265-451             .................aed--KKAQE.EnDAVKDAVKFTAD....FYQTVTEKYGVQSAKIAQELAEAA...K...GKQLRSVDEALKAFDN.YKDVLNKKFSVKDREAIAKALESID.RDLMAKNLAKFSKAFGLVGKAIDGVDVVKEINNGMETGNWRPLLVKLET.....L.....A.AGRGA....ASLVAF...T.F......G..V.........MTASP..L..GILGFG..L....LMVITSTLINDALIEKINK-y...................................
B1VJ71_PROMH/284-482                 ................fiqd-----AE.K.EALMGAADIITNtgekISKHLGEKYKTIANEIASDLRN-F...Q...GKKLRSLSDALKMMEK.INRNPNIKIKQADRVVLANAVRHVD.TKILSENFQRLGKSFGVLGKVLSVEKLREKAAIGFETGNWKPLMLEVEA.....MiisgyA.TGIAIsiaiSFISSI...AsF......L..A.........IGALPttL..AIIATI..M....LISYLASLIDDKVVDKINNL....................................
A0A3N1J581_9ENTR/285-476             qrkaqaeknaqdmfssfptn-------.-.-----PISIASD....FYKSLADKFGVRLSDEAKSLAEAA...T...GKKIRNASEAIAAFDK.YKDVLNKKFSLADREAIAKALESLD.KQMMAAQLKKFSKMFGIVGEALQWSDFVTGLVKGFRTGNWNDAIIGGEK.....I.....A.ASKLA....SLAVVV...A.F......S..S.........MAVTP..I..GIIGFA..A....ILAVTSALITDERLKKMND-f...................................
B4F067_PROMH/378-561                 ..............pqqeke-------.F.NDIKDGVKFTIS....FYEKVTQEFGKKAAQLSRELAEQA...K...GKTIRSVEDALRTYEK.YGQNINNKINAKDRAAIIKALESID.AKQLASNLGKFSKGLGYTNHAINAVELLVEFKKAVKTGNWRPFFVKATA.....I.....T.AGMAA....VALTAF...A.F......S..L.........IVGGP..V..GILGYA..L....IIATVSALIDDALVEKV---ssa.................................
B2VE54_ERWT9/348-530                 ............ddekemge-------.-.--ILSAIKFTSD....FYKELTEKWGEKSAEIAQELAWEA...K...GRQIRNADEALEAFEK.YKNVLNKKFSTKDQEAIGKALESLS.QDEMTKNFARFSKGFGLIGSGIDAYETAIELKKAMDTNNWRPFYVKLET.....L.....A.AGKVA....TFLTAF...A.Y......S..I.........ILGTP..M..GILGFA..L....IMTLVGFFVNDKFVEKIN--rk..................................
C0AY95_9GAMM/234-421                 .........ankkeqidndf-------.-.NQLHDSIKFTAD....FYKEVFNAYGDKARKLAESLAQQV...R...GKTIRNVDDALKAYEK.YKVDINRRINAKDRKAIATALESFK.IDDIAQKLKKFSKGMTYTGYAINFSDWATELHKAIQTDDWRPFFVKTET.....L.....I.VGMAA....TSVAGF...T.F......G..V.........LLGGP..I..GILGYG..L....IMAGVGALINDDLVEKANQ-f...................................
A0A2Z2EQH1_9CAUD/175-370             ......nesqasvidttsgi-------.-.---------ITD....SGKTLSGKLGDKYNTLAKEAADNIknfQ...GKKLRSFNDAMASINE.LANNPKMKLSQADKTVVSNALKQMD.LSALADRFKGLEKAFTWGDRLLKAEKIRDGVVTGVTTGDWQKLAFEVEA.....M....yL.SGVAG....AVALGI...T.T......A..M.........ISTVA..ValSLPSVA..VsaltVVAVIG--------------isiltsyidadkakalnn..................
A0A0Q4MTM7_9GAMM/75-260              ......kssyilsgtgnelg-------.-.------------....------KLLGDKYSTIANEIAEDIknfQ...GKKIRSYDDVLKSINK.ITKNPAMVINDADKVAITNAIKSLE.ADDIAKNIKGISKSFAYANLAVKIENVRQKTIIGFENGDWGPLMLEVQSwvvggL.....V.AGGALa.ilSNFVAP...Y.L......A..L.........LLGIP..L..TAVTIAgvI....IIGILASFIDDKLVDRINN-e...................................
A0A7X6IK78_9PSED/200-392             ......narlaaaeearqid-------.-.-EHKRAVAFVAD....ANKYILEKYGANLHQVVMDLQKDI...S...GKKIRSYTEAMQTFEQ.VRTNPNARLSPQDTRALVDALNALD.KATYMENVNRLAKGFGVTGKVVQAHSVIEKMVIGFRDGDWKPLMLELES.....I.....A.AGAGA....GALLAL...A.L......P..P.........-----..-..------..-....--------------------llsliwvppaavvvvtgiaiaaaaifldakavetin
A0A427K289_9GAMM/111-294             ...........aqinytred-------.-.--IANAVKATSD....FYQEVTAKYGERASGLAQSFAEEA...K...GKTIRNMDQALAAFNN.YKNSLGVKFSAQDRNAIHSALKSMD.YANMAKQLSIYNKAFGYYGKFSDLYDITQELIKSLETDNWRPFFVKIET.....F.....T.AGKVA....TAVTAF...A.F......S..I.........LIGVP..L..GIVSFA..V....IMATVGALVNDKLINKIN--ag..................................
A0A3N1IY76_9ENTR/251-434             ................iere-----KE.D.TDLKDAVKATAD....FYKELTEKFGEQSAKVSEELAAAA...K...GKTIKNADEALKAFEK.YKDVLNKKFSVKDREAISNALESLK.RDEMAKNFARFSKAFKYVGNTIDVYDTAMELKKAVETDNWRPFFVKLES.....L.....A.AGRAA....TAITAF...S.Y......S..I.........ILGTP..L..GIFGFA..I....MMTLVSVFVDDKFVEKIN--sa..................................
D2TV62_CITRI/314-510                 ...............mnrdr-----IQ.S.DVLNKAAEVISD....MGNKVGDYLGEAYKSLAREISDDIknfQ...GKTIRSYDDAMASLNK.VLSNPGFKVNRADSDALANAWRSLD.AQDMANKLGNISKAFKVADVVMKVEKVREKSIEGYETGNWGPLMLEVES.....W.....VlSGIAS....TVALGI...F.S......A..TlgayalslgAPAVA..V..GIVGIL..-....LAATVGAFINDKFADTLNN-a...................................
A0A328TKF4_9GAMM/1-84                .........maddivnnikn-------.-.------------....-----------------------F...Q...GKKICSYNDAMNSLNK.VLSNPSLKISAGDKAALSNAMAHIN.ANDMANKLGNLSKGFRVAGWAQKV-------------------------.....-.....-.-----....------...-.-......-..-.........-----..-..------..-....--------------------snvlen..............................
Q9I4Y4_PSEAE/310-494                 ....................AERKAAE.E.QALQDAIKFTAD....FYKEVTEKFGARTSEMARQLAEGA...R...GKNIRSSAEAIKSFEK.HKDALNKKLSLKDRQAIAKAFDSLD.KQMMAKSLEKFSKGFGVVGKAIDAASLYQEFKISTETGDWKPFFVKIET.....L.....A.AGAAA....SWLVGI...A.F......A..T.........ATATP..I..GILGFA..L....VMAVTGAMIDEDLLEKANNL....................................
#=GC seq_cons                        ................p.tt............h.tuhphssD....hhpplspchGpphsplAp-lApth...p...GKpIRshs-AhpuhpK.hpss.shKhstpDRpAIssALcSl-.tsphAcpltphSKuFuhsupslch.clhtchhpuhcTssWpPhhlchEo.....l.....s.uGhuA....sshsuh...s.a......u..h.........hhusP..l..GIlGhu..l....lhuhhuuhlsDplh-+hN......................................
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