#=GF ID ComC
#=GF AC PF03047.18
#=GF DE COMC family
#=GF AU Mifsud W;0000-0002-9805-6461
#=GF SE Pfam-B_2107 (release 6.4)
#=GF GA 20.40 20.40;
#=GF TC 20.40 20.40;
#=GF NC 20.20 20.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF CL CL0400
#=GF RN [1]
#=GF RM 7479953
#=GF RT An unmodified heptadecapeptide pheromone induces competence for
#=GF RT genetic transformation in Streptococcus pneumoniae.
#=GF RA Havarstein LS, Coomaraswamy G, Morrison DA;
#=GF RL Proc Natl Acad Sci U S A 1995;92:11140-11144.
#=GF RN [2]
#=GF RM 9352904
#=GF RT Natural competence in the genus Streptococcus: evidence that
#=GF RT streptococci can change pherotype by interspecies
#=GF RT recombinational exchanges.
#=GF RA Havarstein LS, Hakenbeck R, Gaustad P;
#=GF RL J Bacteriol 1997;179:6589-6594.
#=GF DR INTERPRO; IPR004288;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists exclusively of streptococcal competence
#=GF CC stimulating peptide precursors, which are generally up to 50
#=GF CC amino acid residues long. In all the members of this family, the
#=GF CC leader sequence is cleaved after two conserved glycine residues;
#=GF CC thus the leader sequence is of the double- glycine type [2].
#=GF CC Competence stimulating peptides (CSP) are small (less than 25
#=GF CC amino acid residues) cationic peptides. The N-terminal amino
#=GF CC acid residue is negatively charged, either glutamate or
#=GF CC aspartate. The C-terminal end is positively charged. The third
#=GF CC residue is also positively charged: a highly conserved arginine
#=GF CC [2]. A few COMC proteins and their precursors (not included in
#=GF CC this family) do not fully follow the above description. In
#=GF CC particular: the leader sequence in the CSP precursor from
#=GF CC Streptococcus sanguis NCTC 7863 Swiss:O33758 is not of the
#=GF CC double-glycine type; the CSP from Streptococcus gordonii NCTC
#=GF CC 3165 Swiss:O33645 does not have a negatively charged N-terminus
#=GF CC residue and has a lysine instead of arginine at the third
#=GF CC position. Functionally, CSP act as pheromones, stimulating
#=GF CC competence for genetic transformation in streptococci. In
#=GF CC streptococci, the (CSP mediated) competence response requires
#=GF CC exponential cell growth at a critical density, a relatively
#=GF CC simple requirement when compared to the stationary-phase
#=GF CC requirement of Haemophilus, or the late-logarithmic- phase of
#=GF CC Bacillus [1]. All bacteria induced to competence by a particular
#=GF CC CSP are said to belong to the same pherotype, because each CSP
#=GF CC is recognised by a specific receptor (the signalling domain of a
#=GF CC histidine kinase ComD). Pherotypes are not necessarily
#=GF CC species-specific. In addition, an organism may change pherotype.
#=GF CC There are two possible mechanisms for pherotype switching:
#=GF CC horizontal gene transfer, and accumulation of point mutations.
#=GF CC The biological significance of pherotypes and pherotype
#=GF CC switching is not definitively determined. Pherotype switching
#=GF CC occurs frequently enough in naturally competent streptococci to
#=GF CC suggest that it may be an important contributor to genetic
#=GF CC exchange between different bacterial species [2]. The family
#=GF CC Antibacterial16, streptolysins from group A streptococci, has
#=GF CC been merged into this family.
#=GF SQ 47
#=GS A0A434ADW9_9BACT/1-24 AC A0A434ADW9.1
#=GS A0A249T2E2_9BACT/1-24 AC A0A249T2E2.1
#=GS Q8DRH5_STRR6/1-25 AC Q8DRH5.1
#=GS A0A2L0D500_9STRE/1-35 AC A0A2L0D500.1
#=GS Q7CRB4_STRR6/1-31 AC Q7CRB4.1
#=GS A0A380KXM1_9STRE/1-36 AC A0A380KXM1.1
#=GS T1ZE54_STRIT/1-31 AC T1ZE54.1
#=GS Q8CVC8_STRMU/1-26 AC Q8CVC8.1
#=GS I6L8Z2_STRMU/1-32 AC I6L8Z2.1
#=GS A0A329ZRE4_9HELI/45-64 AC A0A329ZRE4.1
#=GS Q5M2V9_STRT2/1-30 AC Q5M2V9.1
#=GS A0A7X6S0F7_9STRE/1-32 AC A0A7X6S0F7.1
#=GS A0A1G6S0E6_9BACT/1-29 AC A0A1G6S0E6.1
#=GS A0A1M5CXI2_9BACT/1-25 AC A0A1M5CXI2.1
#=GS CSP1_STRR6/1-31 AC P60243.1
#=GS F9PXG0_9STRE/1-28 AC F9PXG0.1
#=GS G5JMR3_STRCG/1-33 AC G5JMR3.1
#=GS A0A249SWK1_9BACT/1-29 AC A0A249SWK1.1
#=GS A0A4Y8KXN2_9BACT/1-25 AC A0A4Y8KXN2.1
#=GS A0A3L7JH35_9BACI/1-19 AC A0A3L7JH35.1
#=GS A0A172QAG2_9STRE/1-27 AC A0A172QAG2.1
#=GS A0A434AWL0_9BACT/1-24 AC A0A434AWL0.1
#=GS A5M595_STREE/1-25 AC A5M595.1
#=GS A0A434AWJ6_9BACT/1-24 AC A0A434AWJ6.1
#=GS A0A434AFK6_9BACT/1-24 AC A0A434AFK6.1
#=GS A0A2V3PS06_9BACT/1-26 AC A0A2V3PS06.1
#=GS A0A249SWM7_9BACT/1-28 AC A0A249SWM7.1
#=GS A0A554VNZ6_9FLAO/1-28 AC A0A554VNZ6.1
#=GS A0A139NEP3_9STRE/1-36 AC A0A139NEP3.1
#=GS Q8DSB2_STRMU/1-30 AC Q8DSB2.1
#=GS I5BSN9_9BACT/1-25 AC I5BSN9.1
#=GS A0A249SXD3_9BACT/1-28 AC A0A249SXD3.1
#=GS J0VAC3_STREE/1-31 AC J0VAC3.1
#=GS A0A172Q608_9STRE/1-27 AC A0A172Q608.1
#=GS T0S6W7_LACLC/1-30 AC T0S6W7.1
#=GS A0A4P7ZX59_9SYNE/1-32 AC A0A4P7ZX59.1
#=GS A5M6E4_STREE/1-31 AC A5M6E4.1
#=GS A0A850R7A5_9LACO/1-28 AC A0A850R7A5.1
#=GS Q8DSB3_STRMU/1-29 AC Q8DSB3.1
#=GS A0A4Q7PGC4_9FLAO/1-23 AC A0A4Q7PGC4.1
#=GS G5JMW2_STRCG/1-30 AC G5JMW2.1
#=GS A0A1M5GAW0_9BACT/1-24 AC A0A1M5GAW0.1
#=GS J1P1V9_STREE/1-25 AC J1P1V9.1
#=GS J1DAV8_STREE/1-31 AC J1DAV8.1
#=GS A0A0B1T0W6_OESDE/26-50 AC A0A0B1T0W6.1
#=GS T0S6I1_LACLC/20-51 AC T0S6I1.1
#=GS A5M8W5_STREE/1-31 AC A5M8W5.1
A0A434ADW9_9BACT/1-24 ............mk---.-----NFETLNTQDLQNIKGG-------yqdksi...
A0A249T2E2_9BACT/1-24 ..............MKK.---ITQFKTLTRTDLKIVKGGG------lt.......
Q8DRH5_STRR6/1-25 .............mMKN.---LNNYREISNKELQEIKGGF------gv.......
A0A2L0D500_9STRE/1-35 ........mkkqtn--KhLKAIDNFPTLTSQELEHIEGGANW----flt......
Q7CRB4_STRR6/1-31 ..............MDK.KQNLTSFQELTTTELNQITGGGWWEEL-l........
A0A380KXM1_9STRE/1-36 mkktitvadfkeak---.-----KFTTLTNKDLDKVIGGDGRV---gy.......
T1ZE54_STRIT/1-31 ..............MDK.KQTLDHFRTLTSQELEQVVGGGWLEDL-l........
Q8CVC8_STRMU/1-26 ..............MNT.-KMMEQFETMDAETLSHVTGGG------ly.......
I6L8Z2_STRMU/1-32 ..............MKKtLSLKNDFKEIKTDELEIIIGGSGSLSTF.........
A0A329ZRE4_9HELI/45-64 .............r---.--------TLNETELEEVKGGGWWSDI-.........
Q5M2V9_STRT2/1-30 ..............MAN.-NTINNFETLDNHALEQVVGGSGWMDYI.........
A0A7X6S0F7_9STRE/1-32 ..............MTKqTKSLTHFSELSSSELHRISGGDWWSD--wm.......
A0A1G6S0E6_9BACT/1-29 ..............MEK.LNAL-KFDALTTAEMNQIAGGTWRAD--f........
A0A1M5CXI2_9BACT/1-25 ..............MKK.-VALDQFKKLSSKELSKVQGG-------ak.......
CSP1_STRR6/1-31 ..............MKN.TVKLEQFVALKEKDLQKIKGGEMRLSKF.........
F9PXG0_9STRE/1-28 ..............MEK.TVKLEQFKKLTEKELQEIQGGDWR----f........
G5JMR3_STRCG/1-33 ..............MNT.-NILENFEEMNPEDLNTITGGG------ffdsvtdfv
A0A249SWK1_9BACT/1-29 ..............MKK.KNLINKFDTLKRAALQQINGGG------nnsn.....
A0A4Y8KXN2_9BACT/1-25 ..............MKK.-TGLNNFKQLNAKELNKIQGG-------ik.......
A0A3L7JH35_9BACI/1-19 ............mk---.--ELNQFVEIKAKDLKQIE---------.........
A0A172QAG2_9STRE/1-27 .....mtrkidnvv---.-----KFEELTSEELQQISGG-------ia.......
A0A434AWL0_9BACT/1-24 ............mk---.-----NFETLNTQNLQNIKGG-------yqdksi...
A5M595_STREE/1-25 ...........mmk---.--DLNNYREISNKELQEIKGGF------gv.......
A0A434AWJ6_9BACT/1-24 ............mk---.-----NFETLDTQDLQNIKGG-------yqdksi...
A0A434AFK6_9BACT/1-24 ............mk---.-----NFETLNTQDLKNIKGG-------yqdksi...
A0A2V3PS06_9BACT/1-26 ..............MKK.-KSIKNFKKLENKDLKKIKGGG------sh.......
A0A249SWM7_9BACT/1-28 ..............MKK.---KTQFEKITRTQLKKIKGGGTVMK--tm.......
A0A554VNZ6_9FLAO/1-28 ..............MKN.---LNEFESLNETELTEINGGCG-----icdfi....
A0A139NEP3_9STRE/1-36 ..meqtqkqittfa---.--NLNQFASLDEKELVQVIGGDGR----ft.......
Q8DSB2_STRMU/1-30 ..............MNT.-QKLNQFETMDTETLATIEGGMTWAEIG.........
I5BSN9_9BACT/1-25 ..............MKN.----NNFIELRNDALNTINGGAWSL---v........
A0A249SXD3_9BACT/1-28 ..............MKK.--TISQFEVISRHDLQQINGGGSR----hal......
J0VAC3_STREE/1-31 ..............MDK.KQNLTSFQELTTTELNQITGGGLWEDL-l........
A0A172Q608_9STRE/1-27 ..............MNT.-KTFEQFATLTDAELSAVEGGGM-----ew.......
T0S6W7_LACLC/1-30 ..............MENvKNSLELFTELTDEELENIHGGQ------nmsm.....
A0A4P7ZX59_9SYNE/1-32 ...........mst-NT.TELKTNITELKNKELETIQGGLGS----til......
A5M6E4_STREE/1-31 ..............MDK.KQNLASFQELTTTELNQITGGGLWEDI-l........
A0A850R7A5_9LACO/1-28 ..............MKT.---INSFKILNESKLQQVSGGRRR----knvi.....
Q8DSB3_STRMU/1-29 ..............MKTqTEIWKRFEALDTADLAIIQGGS------eni......
A0A4Q7PGC4_9FLAO/1-23 ..............MKN.---LENFKKLNRKELACIKGGQ------d........
G5JMW2_STRCG/1-30 ..............MTT.-QTLEQFDAMTVQELAAIEGGATVED--dg.......
A0A1M5GAW0_9BACT/1-24 .............m---.---KTNFKQLKTKEMNKVQGGA------cats.....
J1P1V9_STREE/1-25 ...........mmk---.--DLNNYREISNKELQEIKGGF------gv.......
J1DAV8_STREE/1-31 ..............MKN.TVKLEQFVALKEKDLQKIKGGEMRLSKF.........
A0A0B1T0W6_OESDE/26-50 ..............MKN.VVKITDFTALDSKVLNNVIG--------tv.......
T0S6I1_LACLC/20-51 ..............MKTqELNLKQFVMLSEKELQEISGGGGWGSAF.........
A5M8W5_STREE/1-31 ..............MKN.TVKLEQFVALKEKDLQKIKGGEMRLSKF.........
#=GC seq_cons ..............Mpp....lppFcpLssp-LppIpGGt......h........
//
