#=GF ID ComR_TPR
#=GF AC PF18710.5
#=GF DE ComR tetratricopeptide
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08223
#=GF GA 26.50 26.50;
#=GF TC 26.50 26.70;
#=GF NC 26.40 26.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Repeat
#=GF CL CL0020
#=GF RN [1]
#=GF RM 27907189
#=GF RT Structural Insights into Streptococcal Competence Regulation by
#=GF RT the Cell-to-Cell Communication System ComRS.
#=GF RA Talagas A, Fontaine L, Ledesma-Garcia L, Mignolet J, Li de la
#=GF RA Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle MJ, Prehna
#=GF RA G, Hols P, Nessler S;
#=GF RL PLoS Pathog. 2016;12:e1005980.
#=GF RN [2]
#=GF RM 27907154
#=GF RT Pheromone Recognition and Selectivity by ComR Proteins among
#=GF RT Streptococcus Species.
#=GF RA Shanker E, Morrison DA, Talagas A, Nessler S, Federle MJ, Prehna
#=GF RA G;
#=GF RL PLoS Pathog. 2016;12:e1005979.
#=GF DR INTERPRO; IPR040799;
#=GF DR SO; 0001068; polypeptide_repeat;
#=GF CC In Gram-positive bacteria, cell-to-cell communication mainly
#=GF CC relies on extracellular signaling peptides. ComR is a member of
#=GF CC the RNPP family, which positively controls competence for
#=GF CC natural DNA transformation in streptococci. It is directly
#=GF CC activated by the binding of its associated pheromone XIP [1].
#=GF CC The crystal structure analysis of ComR shows that it contains an
#=GF CC N-terminal helix-turn-helix (HTH), DNA binding domain (DBD) and
#=GF CC a C-terminal tetratricopeptide repeat (TPR) domain. The TPR
#=GF CC domain is composed of 11 alpha-helices forming 5 TPR motifs
#=GF CC followed by an additional C-terminal alpha-helix 16 called CAP.
#=GF CC The pheromone XIP binding site is found in the TPR region.
#=GF CC Biochemical and mutational analysis indicate that, if the
#=GF CC interacting XIP is accepted it can then trigger the
#=GF CC conformational change of the TPR domain to open the DBD-TPR
#=GF CC interface to allow dimer formation that is required to bind DNA
#=GF CC [2].
#=GF SQ 68
#=GS A0A172Q9H5_9STRE/75-281 AC A0A172Q9H5.1
#=GS A0A1L8QQ60_9ENTE/1-211 AC A0A1L8QQ60.1
#=GS Q8E2E0_STRA5/73-296 AC Q8E2E0.1
#=GS A0A1E5GSY1_9ENTE/63-280 AC A0A1E5GSY1.1
#=GS E1M6K6_9STRE/71-193 AC E1M6K6.1
#=GS A0A172QA32_9STRE/72-295 AC A0A172QA32.1
#=GS A0A1Q8EB20_9STRE/75-295 AC A0A1Q8EB20.1
#=GS F5X439_STRPX/73-294 AC F5X439.1
#=GS A0A0E4CTV3_9STRE/73-296 AC A0A0E4CTV3.1
#=GS G5KFI4_9STRE/1-49 AC G5KFI4.1
#=GS Q8DVT6_STRMU/75-294 AC Q8DVT6.1
#=GS A0A2X3VIM9_9STRE/75-293 AC A0A2X3VIM9.1
#=GS A8AZW8_STRGC/82-296 AC A8AZW8.1
#=GS A0A2L0D697_9STRE/78-290 AC A0A2L0D697.1
#=GS G5KFI5_9STRE/73-240 AC G5KFI5.1
#=GS J1P3S6_STREE/76-160 AC J1P3S6.1
#=GS A0A3P1V774_9STRE/74-297 AC A0A3P1V774.1
#=GS Q8DND0_STRR6/70-291 AC Q8DND0.1
#=GS K1LYB9_9LACT/75-296 AC K1LYB9.1
#=GS E1M6K7_9STRE/1-73 AC E1M6K7.1
#=GS A0A3L9DNT9_9STRE/73-296 AC A0A3L9DNT9.1
#=GS J1NTA4_STREE/8-83 AC J1NTA4.1
#=GS J0V3D8_STREE/2-124 AC J0V3D8.1
#=GS A0A3L8GRC0_STRIN/72-295 AC A0A3L8GRC0.1
#=GS A0A380K4J4_9STRE/76-120 AC A0A380K4J4.1
#=GS A0A172Q9D4_9STRE/76-290 AC A0A172Q9D4.1
#=GS A0A8D0F567_STROC/14-110 AC A0A8D0F567.1
#=GS A0A139NF75_9STRE/74-297 AC A0A139NF75.1
#=GS Q9A1Y2_STRP1/73-296 AC Q9A1Y2.1
#=GS Q5M612_STRT2/75-294 AC Q5M612.1
#=GS A0A1G6BIT0_9STRE/73-296 AC A0A1G6BIT0.1
#=GS A0A242K4G0_9ENTE/75-293 AC A0A242K4G0.1
#=GS A0A1Q8E6R5_9STRE/73-296 AC A0A1Q8E6R5.1
#=GS A0A380K563_9STRE/74-293 AC A0A380K563.1
#=GS Q8DWI6_STRMU/73-296 AC Q8DWI6.1
#=GS A4VSD6_STRSY/78-299 AC A4VSD6.1
#=GS A5MCD8_STREE/76-290 AC A5MCD8.1
#=GS A0A139NHK9_9STRE/15-234 AC A0A139NHK9.1
#=GS A0A1Q8EAZ8_9STRE/74-277 AC A0A1Q8EAZ8.1
#=GS J1DMI9_STREE/1-127 AC J1DMI9.1
#=GS A0A1T4MJM7_9ENTE/73-293 AC A0A1T4MJM7.1
#=GS A0A2X3W5P8_9STRE/73-296 AC A0A2X3W5P8.1
#=GS A0A6M0L5D2_9LACT/75-295 AC A0A6M0L5D2.1
#=GS A0A242K672_9ENTE/1-112 AC A0A242K672.1
#=GS A0A380K4I3_9STRE/72-294 AC A0A380K4I3.1
#=GS A0A2L0D265_9STRE/72-295 AC A0A2L0D265.1
#=GS A0A242K4M9_9ENTE/75-165 AC A0A242K4M9.1
#=GS F9PYQ6_9STRE/1-142 AC F9PYQ6.1
#=GS A0A139NN13_9STRE/1-218 AC A0A139NN13.1
#=GS A0A242K5G9_9ENTE/1-125 AC A0A242K5G9.1
#=GS A0A5C5TCY1_9STRE/75-293 AC A0A5C5TCY1.1
#=GS A0A139NAG1_9STRE/71-295 AC A0A139NAG1.1
#=GS A8AZ18_STRGC/75-293 AC A8AZ18.1
#=GS A8AZ57_STRGC/75-293 AC A8AZ57.1
#=GS G6ENH8_STRTR/75-294 AC G6ENH8.1
#=GS A0A139NGV0_9STRE/15-234 AC A0A139NGV0.1
#=GS A0A380K385_9STRE/73-294 AC A0A380K385.1
#=GS B9DST9_STRU0/72-295 AC B9DST9.1
#=GS G5JQ00_STRCG/75-294 AC G5JQ00.1
#=GS A0A4R0QFG6_9STRE/1-207 AC A0A4R0QFG6.1
#=GS A5MAB8_STREE/8-229 AC A5MAB8.1
#=GS A0A242K4G7_9ENTE/75-293 AC A0A242K4G7.1
#=GS A0A139NGW5_9STRE/72-296 AC A0A139NGW5.1
#=GS A0A3P1VDL4_9STRE/75-293 AC A0A3P1VDL4.1
#=GS A0A380K3S0_9STRE/1-164 AC A0A380K3S0.1
#=GS A0A172Q9J0_9STRE/77-295 AC A0A172Q9J0.1
#=GS G5K5D9_9STRE/73-296 AC G5K5D9.1
#=GS Q8CY78_STRR6/97-164 AC Q8CY78.1
A0A172Q9H5_9STRE/75-281 .................................................PQAYFEQKYKLIK.FPSYGDAERLAPKK------------QLPEEELFTLDLLEKSFDRMTVGESGSAEQIYEDFFKQLLSKETYSLNDILLVKYYFI...-----QCQDSVFDRKTFQHLVA...RLLKQEITGDEYYNVELLGALS.ALAG.VYVVSADYSDMKPTLDKMDDVVNQTMQHVYKPILLMLEAKYYLYQGHNFQKAKSCYDLALTLAENFGDTVLINNLKKER...................
A0A1L8QQ60_9ENTE/1-211 .................................................-----------MK.QTMYKDSIRAEKVNLLFDQIYDNFYDQINEEEQLTIDILRATTDIVVFNNVQFESGLLKEYFPQTLLKKELCELDFLLIYLYFF...--YIFGKDKAYKNRNTTKQAIN...KLVKNSDYSNDSNAYLAIKIHI.IALN.FLSELKDYDTYKQLLDISKTISEENQEFQKKPILQMMEAKYLLFHVSDTEKAKVMYRVAAKTAMLLGDNIAHDQIL---lem................
Q8E2E0_STRA5/73-296 .................................................PKRYKELKYLILR.IPTYADAERLKLRECQFDHIFEEFYDNLPEDECLAIDSLQAKFEVYQTGDINFGVEVLCECFDKVKYKEKYTLNDLIIIDLFLT...CAVVSKFNNRAFTKEVFQTICK...TLISQNHKLTAEDLFWFNHVLL.NCVF.VGLCLNSEECLAEMLEVSRQTMVSTHDFHKMPLYFMYQWKYFITIDNDIKSAENAYQQSIMFSKMIDDKHLIKKLELEW...................
A0A1E5GSY1_9ENTE/63-280 .................................................PERYIRLKMSLFK.RPPQYNHAMEKIVEDIFEEIYKDYYEVLPEEEQLLVDIAQAQNDVNLSEKIDFGEGILQEYFFQVKNKKEYSENDLLIVHLYFG...-----CCHYKPYDDQEFDTLVE...KCLEQVNYSSELGLIILNRVLG.TIAG.LYIISDQYDKVLNVIKISNTIMKMSQDFHRKPIIDMVEGKYWL-HCNDIEKANKKYNDAMVLAQLHGEDLLAERIKMEW...................
E1M6K6_9STRE/71-193 .................................................PKRYQELKYFLLH.HPDYGDKELQEQKEEYFDEIFECFYDDLPRDEKVLVDCLQAIDEVRATGNSLYGTSLLENGLHNLLFRDVYKAEELLRLRLYFA...CNLMDGLKAGEIKESEHETILY...F---------------------.----.-------------------------------------------------------------------------------min................
A0A172QA32_9STRE/72-295 .................................................PARYEELKYLIMR.TPIYADTNRVELVETYFDEVYEQYYDNLPEEEQLAIDILQSSLDVQITDNIEFGSILLQDYFEQVKAKRIYSINDLLIVGLYFY...QISSESIYSDDISSETLDMLAG...RLILQTHYIVPSYLFLLRDVLL.QCGG.MLLLTHSYQHLPAIVQELNTIINKTQDYQKKPLVDMLEWKYYLYVKQNFSRAQQKYQQAVQFSAMIDDAVLKENLEKEW...................
A0A1Q8EB20_9STRE/75-295 .................................................PQDYLDLKYLALR.LSAFGQEEKLDEMAACVEEMAERFYDQLPEDERVIIWILRCRIRMCRGIKPATRTQIFDDYLEQVQRRKVYGINDLLLIHVYFL...---ACQLIEDLLEEPFYRQMVD...CLLEQDQHLKIEEWFILRDVLI.ACLT.AGLQYGLAYKHREMLALLEQMMELTQDYQKKAVVYLLEWKCAMMFRQDVALARKSYQQALAFSHVLRDTYLRQQLMSEW...................
F5X439_STRPX/73-294 ................................................t--RYKELKYLLLR.TPTYGDEERLKRQTSYFDEISEKYYEVIPEEERLIIDCLQSKLDVHFSDDVNFGEGILNDYFDQVIRKKNFQINDLVLIDLYFA...CLASAKSFVGIYSLDLYDKLME...CLLDQENLSPET-SLILNNVLL.NNVD.LVLRFHRESFMKRIIIKSDTIMTSVHDFQRRPVLSLVEWKYYLQFKKDFLAAQKSYSNAILFANLIGDTYLENKLIEEW...................
A0A0E4CTV3_9STRE/73-296 .................................................PEDYLNLKYDILR.TPTYGENKKIDWRDQILTEIYDNYYDDLPEEEQLAVDTIQSFFDVHDTSEAIYGKEILEEYFFQISHKDAYSINELLMIRLFLE...HARMTELSKFPKENAVFQHLLK...TLPCQVNVVRPKDLFILRDVLF.VMVG.VAGSKEQNDCIPAFIQTIEQIMNRTQDYQKLPILKMISWKYKLYVDKNKKDAEQLYEAAKLSAGMIGDPNLLEKIENEW...................
G5KFI4_9STRE/1-49 .................................................-------------.------------------------------------------------------------------------------------...----------------------...----------------------.----.------------------------------MPIICIMEWKYFLNCLLDFKKAKSCHTKAILFANMMGDDYLEEKINEEW...................
Q8DVT6_STRMU/75-294 .................................................PDDYWELKGQIVK.FPTYADKERLQQKQELIEEIYDKYFDILPEDELLFLDLSENILDSFHEKDIPNIEEIYDDAFEQVLKKETFAFNDYLYMSYFLQ...----KCGKTADYDQTTFKLLEQ...KLLKQELTVDELYNIELLIAVM.EASG.VYALHNDYQNLLPLMKKAQRIIDKAQLHTYKPPLLELEAKYYVKVVKDKKKAKELYQQALVMGEVLGDPVIIADVKMEM...................
A0A2X3VIM9_9STRE/75-293 .................................................PDEYFTMKYQLFK.FPTYGDKERLAQKAQMIEDIYEKYFDCLPEEELYTLELSDNTLDYISTGKTAAAEDIFEDFFKQLFLKKKYTFNDLLLVSYYAV...-----QCQNKGYEEEVLKSLEA...TVLKQDVSGDEYYNIELLGTLT.AIAG.VYLDHAEYSQLKILADRMHDIIAETQQHSAKPIALIYDAKYYLYAENNVEKAKECYDLATLLAQNFGDNILEANLRDE-r..................
A8AZW8_STRGC/82-296 .................................................PKRYLELKNKLIR.SHTYGDEERISILEEMFDEIYENFYEHLPEEEQLLVEVLQVQLDVFSSRDITYGLSLLEEYFQQILKKKKYSYNDLLIINLYFL...-----CCATGLEDKTYFEELSK...KVLLYIDYSDNDRIYILERILI.GILI.QVK----TEDYLIYTKVLREITESTNNFQHKPAIYAFEAKYYLKVEESYEKAEQSYNKAIEFANLLNDQVLASNLLKEK...................
A0A2L0D697_9STRE/78-290 .................................................PQSYVSLKRRIVQ.FKSYEDPERLNYLDGLMDEL-QTYYDSVPEEEQMAIEVLQADLDVFVTHKTAFAEQLIEEYFEQVLLKKAYNWNDYLLISLYLF...-----LCAVGIEDSRYFDYFIP...SIFSKGDLSDPDIAYQMEEVVL.AVLA.QE----NVAYYPDCIDTLDRVIKVTKHYQNKPILEMFKAKLAL-FQGDIEQMESSYQTAFLIAESLDEPILLNRLKME-y..................
G5KFI5_9STRE/73-240 .................................................PKRYKELKYLILR.TPVFTDVSKINLREQQLDEIYEIYYDELPEIEKLAIDCIQATLDTSLTKDVNFGIGILNDYLIQTKKKKKYQINDLILINLYLA...CLDITKKKGNLYDSHFYKTIFE...IIQQNVQNYHIEEKFIVQQILI.QYFL.LSLYYEEFDYLCDIVKLTKQIL---------------------------------------------------------d..................
J1P3S6_STREE/76-160 .................................................PKGFLKLKDELIH.SQTYADKGRIERKEAILEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKRNIF-------------...----------------------...----------------------.----.-------------------------------------------------------------------------------l..................
A0A3P1V774_9STRE/74-297 .................................................PRRYKELKYQILR.APTYLDEVRLQEREAQFDEIFTDYYDQLPEEECLMVDCIQATMDVALSQNIDFGIGIIQDYFEQVKRKKHLLENDLILLELYFI...CLIISNFDAKIYNSQNFDNLVE...NLLEQEKYGDIDNLFLVNKALI.KAFG.ASVRLKKYKKLEEIAVTCRRIMTTTGDFQKMPILNLIEWKYYLYSLNDLPSAEACFENAIKFSQIISDDYLEENLNSEW...................
Q8DND0_STRR6/70-291 .................................................PSAYLELKYQILR.EPIYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLLIRLFFY...--QMLIRKDLAKFINQIEKLML...FLLEQKKVTQIENYFIIRDTLI.SGMC.CLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAKLIGDGFLVKELTEEW...................
K1LYB9_9LACT/75-296 .................................................PFEYYQIKDRLMN.FASYGLKDKIQEKDDLYEIVFQKYYDYLPEEEQIAIDIMHATSDVVNEHIDLYGQAIIDDYFDQVKLKSSYTLNDLLIIRLYLS...--QVDFTNEQYFDDNLIDTMLS...KVLNQVDFIHYNMVNFGISFYI.DSIT.TLFHYKNFNRIEEILTCLDTLIHIDKKAEDLIICTMLKAKWYLYAKNSIPMTKYFYQQAIDYANLFNEVFLADKLTDE-l..................
E1M6K7_9STRE/1-73 ..............................................mgl-------------.------------------------------------------------------------------------------------...----------------------...----------------------.----.-------FHYFKRAIEALNKIGQKTRDFQKQPIVLMLEWKYYI--QTDYDTAKKKYEEAKMMARMFGNEQLIVSLDNEW...................
A0A3L9DNT9_9STRE/73-296 .................................................PKRYKELKYLILR.TPTYLDEERLKVREEQFDEIFEEYYDKLPEAEQVLVDIVQARFEVFNSGNKEFGSSILEDYFEQVKKKKFYGINDMALIDLYLI...CVLVENFDVEFYDEVTYNQFIQ...NLRNQGSYLNVEDLFFLNKIYL.IICS.VLVKKGDYAQLEDYLDELYHLILKSQDFQRMPLYYMYRWKYSLSYLDDKNSAEEFYAHAILFAEMTSDLYLVKKLKDEW...................
J1NTA4_STREE/8-83 .................................................PPAYLELKYQILR.EPIYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHM----------------------...----------------------...----------------------.----.-------------------------------------------------------------------------------s..................
J0V3D8_STREE/2-124 ...........................................lirkdl-------------.------------------------------------------------------------------------------------...----------AKFINQIEKLML...FLLEQKKVTKLENFFIIRDTLI.SGMC.CLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALREERDFSLAESFYQSSKTFAQLIGDEFLVKKLTEEW...................
A0A3L8GRC0_STRIN/72-295 .................................................PKRYKELKHLILR.TPTYKDKEKVRIREKQFDEIFINYYDNLPEEEKLVVDGLQASLDVALSKNINFGSDILNDYFEQIKVKSCFTRNDLIIIDLYLI...CVRTSKFSDAIYDAAVYKSLLK...KTIAQIDCAEIDDFYVLNQVLI.TFYT.ISIQLDRPKELELIISNCNRIMSVVNDFYRMPILYVMEWKYSIKYLDDLKKATSFYHKAKLFAQMTGDSDLANKIEKEW...................
A0A380K4J4_9STRE/76-120 .................................................PKRYLELKNRLTK.THTYGDPKRIKELEGFLDEIYEHYYDSLPEEE----------------------------------------------------...----------------------...----------------------.----.-------------------------------------------------------------------------------...................
A0A172Q9D4_9STRE/76-290 .................................................PKRYLELKNRLIK.SHTYGDKERIAKQEEIFDEIYNNYYDFLPEEEQLLVEALQVQLNVFTSRDIGFALGFLEEYFQQILTKKNYSYNDLLIVYVYFT...-----CCAMGLEDKEYFDELSK...KVLLHVDYSDLEKLYLVERVLL.SILV.QVD----PTEYLIYTKIFREIMKESNHFQHKPVVYVFEAKYYLDIEQNKNKTIESYDKAIMFAKMLNDEVLARNIEIEK...................
A0A8D0F567_STROC/14-110 ......................................segffsvlvqt-------------.------------------------------------------------------------------------------------...----------------------...------------------VVLMnDLAT.VLDAQGHYDEAYSYVKRAAELAKETQHPEEHMVLNNLAA--ILMHKEDFLQAKQVYKEALEQAQQKGDVASVQHIQEE-l..................
A0A139NF75_9STRE/74-297 .................................................PEDYLKLKYQLIR.TTSYGDKDVLSELDEAVDAIFARYFDDLPEEEQFIIEVLQSKLYTYEMEGERFGKPILEENLSKLRDKKQYTINDLLIVDLYQT...HLDDEDLLSKSFDIDCFNAIVR...TTLDSIEGLGREYLFKARDVLL.YVPY.AEFIRKDFRYSKEVLECLNTIMTMTQDYQQKPLVKMMEWQYLLGYKQDVDGAKECYQEAVSLAKLFGNEFLAEKLTEEW...................
Q9A1Y2_STRP1/73-296 .................................................PKRYKELKYLILR.TPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQNDLILLELYLA...YLDIEGMDGQYSDKIFYDSLLD...NLSEQFEQFELDELFIVNKIII.DISS.LSLKNNRLDNLEKAIEMSQKIMAKIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEW...................
Q5M612_STRT2/75-294 .................................................PDEYYEMKNRLIK.FPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFSTNDLLVIDYYFF...----HLYGRKQYDKKLFERIIK...RVLNQEIWTDDVYNIVLFNDLM.AIAA.LKIFHNSFSDFLTVVDKALAVIEKSQLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKA--gk.................
A0A1G6BIT0_9STRE/73-296 .................................................PKRYTELKYLILR.TPTYMDAERLRIREEQFDEIYEKFYEELPEDEQLTITFIQSKFEVYQTGDTEFGTDVIEDYFKQVQKKKLYTLNDIVLIDLFLT...CSIVSNFTSHLFDNAIYELLSS...NLIKQSEYLPIEDLPLLNSVLL.VCAD.ASVRLEKFNLLSNLLSASHSLMTKIQDFQKMPIYNMLMWEYYLFGENNYVQAENHYNQSILFAKMMNDIHLAEKLEKEW...................
A0A242K4G0_9ENTE/75-293 .................................................PKGYLQLKRRLYK.FYTYKEQERKAKKNQLFKEIYETYYDDLPEEEQLSIDVQSATNVLAMTDNVEFGEGILGDYFSQVMQRQEFSVNDLLIIELYLF...-----YIHLREYDEVVFLSLFN...KLVKQIDCSLDVDQFLLIRVLI.VSIS.VFIEYGNYDKIIDAVTAADRVMKSNQDFQKKPILDMYEGKYYLFSQKDSTSAKQKFEEGAKLAELQGDSVISQKILKEW...................
A0A1Q8E6R5_9STRE/73-296 .................................................PDQYVKLKYDILR.TPTYNRADLIDKRNGKLKQIYDRFYDQLPDIERVAIDALQSTIDVLETKSDIFGREIVKKHIPRIERKRKYDVNDLLVIHLFME...HAYLSNLRKKSDSRKMFLKLVA...ELPKQVMLMEPEDLFVLRNVMF.ATIR.VLGAKEICDPIPALFQGLDQIMQITQDFQKYPIFSMLRWKYELLVHRDVNRASSYCKEAMVFAKLMGNLHLMEQLHAQW...................
A0A380K563_9STRE/74-293 ................................................s-KDYLKLKVEFIR.LSTYDDSDRKAKKEEIIDTIFEKYYDNLPSDEQLTLTILSTEMEMLHSKDTTYGEELFKEVQSKIFNIQRITVNEILWMNFYLV...---YISGREDLYSKEKINDILA...IIISI-DNDDELFLELEIKLCV.TLCG.VMIWSNTLEKFSKLRPTFKRLILKHSDSKSIPIYHMMNGKYAMLVEGKRREALLHYDRALEEARFLEDDILYQRISEEM...................
Q8DWI6_STRMU/73-296 .................................................PSRYKELKYLLLR.TPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVNDLILIDLYFS...CLTVSGLDSAIFDSRKYNQLLE...TLLKQVDCLPLEDLFVLNNVLL.NNFG.LLLELKKYDFVKQLIAVSNKIMDRTHDFQKKPIVNLLTWKHHLFVEKDYAEAKKSYDAAILFAQLTENINLRENLEKEW...................
A4VSD6_STRSY/78-299 .................................................PERYSKLKFDVLR.TPTYGNEDLAEKRDAMMTEIYDDYYDELPEEEKIAIDAIQSRIDTLESGTAGFGKEILEDYFEQIFRKRKYELNDLLIVRLHLE...YVRLSSCDSEIF--RQFLKIIE...HLHEQINIINSNDLFVLRDTLL.SCVN.ILGSKKYYEPIPKIFDSVDKIIQSTQDFQKKPIVSVLKWKYALFVDKDRDEAEKHYLDAVLFAKLIENRELEQKIEEDW...................
A5MCD8_STREE/76-290 .................................................PKGFLKLKDELIH.SQTYADKGRIERKEAILEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKKKYFSVNDLLIIELYFF...-----CCAMGLEDKEHFEELAQ...KVLLCSEYEDKASLVQMEKVLL.SLFI.QIQ----TEDSLIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAELLDDQVLVQRILAEK...................
A0A139NHK9_9STRE/15-234 .................................................PDSYYEKKNRLIK.FPTYGDSGRIAQKLQLIAEVHEEYDELLPEDELLTLDIFESVMNFSLLEKGPKTEEIFEDVFLQAQKKKKLSTNDLLVIHYYFL...----ENHDKKYLDKKILEMLCR...KLLNQEISADETHNITLIVVLM.SCAA.VYLMLEEFKTILPIANRLLQFVDEAQLQTYKPGALALKAKYYSRYLGDSERANRYYDKALSFARLLNDDALVRGIKQEK...................
A0A1Q8EAZ8_9STRE/74-277 .................................................PKRYLDLKYLVMR.TGLFGQSTLVAQKEAYLLEMYEEFYDDLPEDEQVAVDVLQSWVDVFVTGQPTFGNRMLEEYFEQVKQRSVYQVNDLLLLELYFY...CV---YLDNSLFNRRLYRHFVN...GLLAQDQHLPVEQLFLLSTVYV.TCVA.VGLNNGYCDGIGQLVKQSKEIMKQIQDFQNLPIVHLQECQILF--LKNRQLAE--------------------------kkveellnsis........
J1DMI9_STREE/1-127 .................................................-------------.---------------------------------------------------------------------------MLIIELYFF...-----CCAMGLEDKEHFEELAQ...KVLLCSEYEDKASLVQMEKVLL.SLFI.QIQ----TEDSLIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAELLDDQVLVQRILAEK...................
A0A1T4MJM7_9ENTE/73-293 .................................................PKRYLELKNLLFRgIKVYQNEERAETVDEQFDEIYNNYFEDLPRYEQDTIELKQILHDMTLTKTAGSAEEIIAESFDRVYKKDDLDLNDFLIIKLYFN...----LSILKNEVDTEEVKTLSQ...KVIEKIESAIDLELLVIGSILT.SIAI.ILIEKKNYEELLKIIEIGEKLRKKTLDFRSKPVFCMLKGKCILFHQKDPELAKQHYQEAITSAEMLEDSFLSEKIKEE-l..................
A0A2X3W5P8_9STRE/73-296 .................................................PRRYKEIKYLLLH.TPTYGNQAKLEERESLFDDIFNNYYDHLPEDEQLIMDALQSKLDIHFSDNINFGRGILNDYFDQVLLKDYYQLNDLIIIDLYLS...CLTINGLEDSIFRQSAFDRIIE...VLICQGDSLPLDDLFMLNNVLL.NNFE.LFFLLKKHKEIEEIILLSNNIMQKIHDFHKKPVVNILEWKYYLLVKNDVKKAEESYHSAVMLAQLIGNAYLAEKLEEEW...................
A0A6M0L5D2_9LACT/75-295 .................................................PEEYYDLKKRIIQ.LHTLQHKEKTQEKEYLFKQIYTHFFDSLTTEEQLSIDILQKEMQIVTTKDFSVGKAILEEHFDHVKRKRTYSFNDLLIIDIFFL...-SILAEVNDFHIYKYYINKFKQ...NLLNHECYYHSEYY-IIQKCFF.ALLG.IITQYDDFSDFYLCLNKLKEILTYTHDIEKKPIINMLEAKYFI-YKKDFKLAKNFYTSAIKGAQYLNDTPLEEKILLE-m..................
A0A242K672_9ENTE/1-112 ................................................m-------------.------------------------------------------------------------------------------------...----------------FLTLFS...RVTDQIDYSIDIEQFLLIKALI.VSIS.VFLEFGNYDKIIDAVTAANKIMNVNQDFQKKPIIDMHEGKYYLFSQKDVPTAKQKFEEGAKLAELQGDSVISQKILKEW...................
A0A380K4I3_9STRE/72-294 .................................................PKRYNELKYLILR.IPTYSDKERLKEREQQFEEIFEDYYDNLPEEEQLIIDGLQSKFEVYQSGNIHFGTDMIAEYFHQVKKKKSYTLNDLAIIDLYLL...IAAISQFDEQHFQKEDFKIICD...TLLIQGEELAVEDRFLLNNLLL.NCVN.IALNLKLAANIQPMLELSHKTMVLIQDFQKMPIYNMYRWKYAL-LQDNQTEAEDYYNQSVMFSKMLNDEHLIQQLDDEW...................
A0A2L0D265_9STRE/72-295 .................................................PFRYKELKYLIMR.TPTYRQEQQIKQITQYFDEIYLDFFEKLPEDEKIAIEVLQTSMDIHLDEDVNFGGDLVRESFQQIQLKKRYELNDLLIIRLYFF...YIYFANFQDTLFDLSIVKKLCG...YLKKQAQFTHPSDLFLLRDILL.QAIT.ILIKLEEFQDASDLIEQTRDIISTTQDYQKQPILDMMEWKLILAQHNNRGAAEAKYNEALLFSRIVGNQYLEEQLIIEW...................
A0A242K4M9_9ENTE/75-165 .................................................PKRYLQLKQRLYK.LYTYKEEERIAKKEQTFDEIYENYYDQLPEEEQLSIDVQQASMDVHLAENADFGDGILHDYLYQILQKKEYSINDLLI------...----------------------...----------------------.----.-------------------------------------------------------------------------------...................
F9PYQ6_9STRE/1-142 ...............................................ml-------------.-------------------------------------------------------------------RTEYSTNDLLLLYLYFL...----SLAVNAERDEITLKKVCL...NIVSQTNYDDTNYIHLLQRVLI.GLVL.YQLDIDYHEFIPEILSILREIMIDIGDTSLKPTVDFIEAKYYLYGEKDKEKALQYYEKAINGAEFLNDMNFKNRVIEEK...................
A0A139NN13_9STRE/1-218 .................................................----------MLR.RPTYGNEELLEKKDQVFREIYDDYYDNLPVEEQMAIDAYSSGLDILRTEDAVYGNEIIHRHFYEIYEKEFYTINDLIVIRLFIIwldTSHQQQTNDVSKNMVYLENLAE...KLPKQRDNYDLEEVFVLRDLLI.NLIIqMGRFQLKLEKLPELFDVVEDIMEESHDLQKKPVLLQLKWTYYLKVKDNYEEAYRCYQDALQLTQLLGDAHLKALLESV-w..................
A0A242K5G9_9ENTE/1-125 .................................................-------------.----------------------------------------------------------------------------MIIELYFH...-----CIHFKDYDEQLFMTLSD...KVIEQVDYSVDVELFLLIKVLL.VAIS.VFIEYDNYDRLIGAVKVANLIMQTNQDFQKKPAVDVFEGKYWLFSQGDVNRAEQKYLD---------------------gaqsvsythldvykrq...
A0A5C5TCY1_9STRE/75-293 .................................................PESYFEKKYLLFK.SSSYGNTERIAEKHRIIEEIYQEYFDLLPDEELLTLDLIERLLDWRLHSEGERADSLFADYFEQVLIKDVYVLNDLLLLQYYAV...-----QCQDVTYESEKFGICFE...KVRKQAIQGNEFYNVALLGVLS.AFAG.SYLVSQDYEKMLQTVERMDEIIQQTLQQVYRPVTLCFRAKYAVYQSRDKQKAQQAYDMAILLAKDIGDDILWTNLTKEK...................
A0A139NAG1_9STRE/71-295 .................................................PKRYQELKYFLLH.HPDYGDKELQEQKEEYFDEIFECFYDKLPRDEQVMIDCLQAIDQVRATDNEQYGQGIIEDYIETLKNQSSFSANDFLKLRLYFL...CMGAEYFKQGTLSKKEQADIKRlfeMVCNQVEQVETSELFLVRDTLF.ASLG.CCETMGALELFEIAIEKLKWITEKTRDFQKTPIIFMVEWKYYI--QTDFNLAYQRYQEAIMFAKLFGNEQLIQSLDGEW...................
A8AZ18_STRGC/75-293 .................................................PPEYIDLKYQLQT.LYHYGDPERLRLLEKIIDEIYENYFENLPEEEQLSIQIAQATVDMVSAKDPSFDQGLLDEYLEQAMKKKELSFNDVEIIQLRLL...-----SLALGDFNQEEFVDLLG...KVILAADYFPLSDLEKVQNTIV.SAAG.VLAHYGIYDILPDIVNVLNDIMTKRRDFQDNIFVHALNWKVALFVEDNLEKAKNDYQKVCMMADLLSEDLVKRNMQEEW...................
A8AZ57_STRGC/75-293 .................................................PSGYLELKYRLEK.LYHYGDGERLQQREELIEEIYRKYFDQLPEEEQLYLQIKQAKNDMVLTENIAYDQGLIDEYLDQALAKEKLTEMDLEIIDLRLL...-----ALGLKDFDKKEFTCLLN...KLLVAVADYPTNGLEKIQTRII.FAAG.VLSHYQEYDRLPEILRVLEELMLRRNDFQDRVFSYALQWKIALFLENNLEKAEDNYQKVKLMLELLPEDVLKENMRLDW...................
G6ENH8_STRTR/75-294 .................................................PDEYYEMKNRLIK.FPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFSTNDLLVIDYYFF...----HLYGRKQYDKKLFERIIK...RVLNQEIWTDDVYNIVLFNDLM.AIAA.LKIFHNSFSDFLTVVDKALAVIEKSQLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKA--gk.................
A0A139NGV0_9STRE/15-234 .................................................PDSYYEKKNRLIK.FPTYGDSGRIAQKLQLIAEVHEEYDELLPEDELLTLDILESVMNFSLLEKGPKTEEIFEDVFLQAQKKKTFLLNDLLVIHYYFL...----EIHRNKYIDEKLLGQLER...KLLVQEISSEEVYDILLITTLM.DIAT.IHMLKDDYKPILQFVNRVLQIADEAQLHTYKPIATTMKAKYFNHYEHNMEKAEQYYDEAMAFAKLLGDDVLAQGIKQEK...................
A0A380K385_9STRE/73-294 ................................................a--DYLELKQKLLR.IPTYGDQARLKEREQYFTSIYERFYDQLPEDEQLIIDCLQSKLDVHFSDNDSFGLGILQDYFEQTFKKSTYTVNDFVFFDLYLV...CFAYKKNQEHFYEEEQYDLVMA...KLLNSNPPLAEE-KFQLNNVLL.NNIK.LAFGLEKWDIIENIVSKSNQLMTEIHDFQKRPILSLIEWKYQLYAKQDTALATQSYQNAILFAKLIGDDYLEKQLSQEW...................
B9DST9_STRU0/72-295 .................................................PKRYQELKYLILR.HPTYMNTDSIEERESQFDIIFEDYYADLPEEEQVLIDRLRSRFEVYQSGNSVYGQDLLLEYIDQIKKKKTYDLNDIFFIDLYLT...CGYVSSFKETLFDKGIFECFTS...KLILLEEKLDFKDLFLLNNVLM.TAIA.VGLTLEEYVKIRTLLNVCRRIMTITQDFQRMPIYYMYEWRYTLFHEKDFRKAPYYYQQSLLFARTHGDEYLKTMIVNAW...................
G5JQ00_STRCG/75-294 .................................................PADYFELKHRLVK.FPTYGDPERVEQKQAMIEEAYEKYFTVLPEEELLFLDLSEKILNWSQTQKIVDIKGIYEDAFEQIQRKKVYTMNDLMVVGYYLF...----GIHNKKYYDKKLFNKLKN...RLLEQEPSTNELYNIDLLSILI.SVLG.VYVQHGNYQATLPVIKKIYQLIEKTQQPIYRPSVMMVEAKYYLNIEEDKERATQLYDQAINFATLLGDEVLADGLRDEK...................
A0A4R0QFG6_9STRE/1-207 .................................................-------------.----MDQDRIKEREEHFDEIFSEYYDELPEEEQLAIDALQSSFEVYHTGQVDFGVDLIPEYFEQLKKKKRYRMNDLILIDLYLT...AAAISYFDSSIFQKSDFLHFCR...NLLQQRKYLLSEELFFLNRLIL.TAVA.MRIYLKDADLVLELLNESNAIMEVTEDFQKKSIYCLLQCEYAIFYKKDKELAKHYYEEALLFAKLFNDKKLQEQLQVEW...................
A5MAB8_STREE/8-229 .................................................PPAYLELKYQILR.EPIYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLLIRLFFY...--QMLIRKDLAKFINQIEKLML...FLLEQKKVTQIENYFIIRDTLI.SGMC.CLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAQLIGDEFLVKKLTEEW...................
A0A242K4G7_9ENTE/75-293 .................................................PQRYQQLKYKLYR.LVTYNEEDRLLKRKRYFNEIYEHYYADLPEEEQLAIDGQQATMEVHLKEETDFGEGILHDYFSQITNKTEYTNNDLLIIELYFH...-----CIHFKNYDDTLFMTLLD...HVIDQIAHSIDTTLLLLHKLLL.LAAS.VFMEYDNYDRLKSVVNASNDIMKKSQDFQKKPVINLLEGKYWLFAQKDKIKAQQKYEDGAQCAQLFGDFVLSDKIMAEW...................
A0A139NGW5_9STRE/72-296 .................................................PQEYLSLKYDILN.TQVYRHPDLMTQVLKQISDVHERFYADLPQEEAYIFGLLEKMLRAYNLEEDQMPITEIKEHLRPLLNHLYFDLNTLIMIRYVLNr.eISYDEKYKKSLFGASYIAMVQE...ELVNLTTTVRREDWFICRDNLI.TALT.LSLNHADHEKCFLLLKVLKENMARFQDVQKKMIVMMLEWKIFL-LNNQLDEAQETYDKTKAFVQIIGDKHVLMKIMEEW...................
A0A3P1VDL4_9STRE/75-293 .................................................PQRYLDLRYKMQR.LPHYGNPERIMEREAILDEIYESFFDNLPEEEQLAVQIEHALLDIAATRRPEFDQGLVDEYLERSLAKSQLDMNDMNILFLRQL...-----ILAFNGFDKEEFVNLLS...RIIHQRTNTTVEGLRLIQNVVI.SSIG.MLCHFEEYDMLYQLHQVLEELMELIKDYSDKAFVYMTRWKINLYLEHNLEAAKENYSSARQLAQLLSEELLFTNIRNEW...................
A0A380K3S0_9STRE/1-164 .................................................-------------.--------------------------------------MQAQLDVFTSRDYQYGLTLLEEYFQQILKKSHYSYNDLLIINLYFF...-----CCALGLEDKSHMEQLAS...RVIEDIDYSDLDRVYATERILV.TLL-.---INAEPEDYLTYTSVLRDIIERTNNFQHKPAVYAFEAKYYLLVKKDKAKAKALYDKAILFANMLNDEALAEEFIRE-s..................
A0A172Q9J0_9STRE/77-295 .................................................PDSYFRMKYRLFK.IPSYSDPQRLDEKIELIETIYDHYFSLLPEEELFTLDLLDNIFDYLRKGQRPAAEDSFAEAFKELLLKPRYSLNDLLLAKFYLI...-----QHHSGAYNKALVQKMET...RALKQEISGDDYYNLELINFFS.DLSA.LYTSHAEYPKLDVPVKRMHDLIRETRQDSMIPLTLMFEAKYYIYVKQCRNKAEELYNAAVWLAESFDDVLLKTKLIHE-r..................
G5K5D9_9STRE/73-296 .................................................PKRFKELKYLILR.TPTYMDGDKLKTREAQFDEIFEDYYDQLPEVEQLVIDCLQSKFDVYQSGDINFGSPLIQEYINQISKNTKYQLNDLLIIDLYLT...CAVVSNFSKYHFDLSLYQEFVN...TILKSEEELLLEDLFMLNNILH.TCLD.VSIRLKDYLKVEQMLLLSQKIMSRIQDFQKIPMYCMYYWKYALYHLNDFAKAKHFYEQSVMFTSLTNDNYLVKKLEKEW...................
Q8CY78_STRR6/97-164 ................................................d-KEYLELKYFLMR.TPTYEDETIAQKKESVFDKIFEEYYDRLPEEERFII------------------------------------------------...----------------------...----------------------.----.-------------------------------------------------------------------------------pnysylalanytvqklpek
#=GC seq_cons .................................................PpcYhcLKh.lh+.hsoYtcpc+lpp+-phh-EIacpYaDpLPEEEplhl-hlpuph-hh.opp.tauptllp-aFpQlhpKcpashNDLlllcLYhh........thptthhspphapplhp...pllpQ.phhp.pthhhlpplLl.shhs.hhh.htphcph.phlphhpplhppspDapc+Pll.hhchKYhLhhppshppAcphYppAhhhAphhsDphLhpplppEh...................
//
