#=GF ID   CompInhib_SCIN
#=GF AC   PF11546.12
#=GF DE   Staphylococcal complement inhibitor SCIN 
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_2qff
#=GF GA   23.00 23.00;
#=GF TC   23.60 24.80;
#=GF NC   20.60 22.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17709514
#=GF RT   Staphylococcal complement inhibitor: structure and active sites. 
#=GF RA   Rooijakkers SH, Milder FJ, Bardoel BW, Ruyken M, van Strijp JA,
#=GF RA   Gros P; 
#=GF RL   J Immunol. 2007;179:2989-2998.
#=GF DR   INTERPRO; IPR021612;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   SCIN is released by Staphylococcus aureus to counteract the host
#=GF CC   immune defense. The protein binds to and inhibits C3 convertases
#=GF CC   on the bacterial surface, reducing phagocytosis and blocking
#=GF CC   downstream effector functions by C3b deposition on its surface
#=GF CC   [1]. An 18 residue stretch 31-48 is crucial for SCIN activity
#=GF CC   [1].
#=GF SQ   18
#=GS A0EX15_9CAUD/1-114      AC A0EX15.1
#=GS Q8SDJ7_BPPHD/1-114      AC Q8SDJ7.1
#=GS A0A385IRD2_9CAUD/1-114  AC A0A385IRD2.1
#=GS A0A345AR32_9CAUD/1-114  AC A0A345AR32.1
#=GS W5R8I4_9CAUD/1-114      AC W5R8I4.1
#=GS A0A143PBX8_9STAP/1-115  AC A0A143PBX8.1
#=GS A7TWS0_9CAUD/1-114      AC A7TWS0.1
#=GS Q2G1D4_STAA8/5-111      AC Q2G1D4.1
#=GS R9QT53_9CAUD/1-114      AC R9QT53.1
#=GS A0A345AQJ4_9CAUD/1-114  AC A0A345AQJ4.1
#=GS Q2FZB7_STAA8/1-116      AC Q2FZB7.1
#=GS A0A1W6JPP0_9CAUD/1-114  AC A0A1W6JPP0.1
#=GS SCIN_STAA8/1-114        AC Q2FWV6.1
#=GS A0A075M4C3_9CAUD/1-114  AC A0A075M4C3.1
#=GS A2FLM7_TRIV3/21-107     AC A2FLM7.1
#=GS M9NSU6_9CAUD/1-114      AC M9NSU6.1
#=GS A0A1P8L6B0_9CAUD/1-114  AC A0A1P8L6B0.1
#=GS A0A1X9H025_9CAUD/1-114  AC A0A1X9H025.1
A0EX15_9CAUD/1-114                 ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGQK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
Q8SDJ7_BPPHD/1-114                 ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGLK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
A0A385IRD2_9CAUD/1-114             ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGQK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
A0A345AR32_9CAUD/1-114             ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGQK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
W5R8I4_9CAUD/1-114                 ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGQK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
A0A143PBX8_9STAP/1-115             ................MNFKQFLLSGLAVALLGSAGANVF-SNQAEAASYGA..YEFRDYDVTAKENLKNLLNA..SSYYKaMAKESGARFYQNKLNQELHF.AKKQQNASNDSQVVTAINRLSAVYNEVF-----qihlqt.
A7TWS0_9CAUD/1-114                 ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGLK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
Q2G1D4_STAA8/5-111                 ................MKIKTYLVAGIKAALLDTTGIKLASKSET-------..TSHTYQHQALVDQLHELIAN..TDLNK.LSYLNLDAFQKRDILAAHYI.AKSAIRTKNLDQMTKAKQRLESIYNSISNPLHS.......
R9QT53_9CAUD/1-114                 ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGLK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
A0A345AQJ4_9CAUD/1-114             ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGLK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
Q2FZB7_STAA8/1-116                 ................MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKylTESQFHDKRIAEELRTLLNK..SNVYA.LAAGSLNPYYKRTIMMNEYR.AKAALKKNDFVSMADAKVALEKIYKEIDEIINR.......
A0A1W6JPP0_9CAUD/1-114             ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGLK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
SCIN_STAA8/1-114                   ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGLK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
A0A075M4C3_9CAUD/1-114             ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGLK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
A2FLM7_TRIV3/21-107                psyeqkykskaeeywk------------------------------LSSLEQ..TEEERELQDLVDKMRSMVEQfrAEINE.LHEMHDNAIQKRDSLINEYQtAKYALDVEEL-----------------------lmkfrtk
M9NSU6_9CAUD/1-114                 ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGQK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
A0A1P8L6B0_9CAUD/1-114             ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGQK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
A0A1X9H025_9CAUD/1-114             ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGQK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
#=GC seq_cons                      ................MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLP..TSNEYQNEKLANELKSLLDE..LNVNE.LATGSLNTYYKRTIKISGhK.AMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.......
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