#=GF ID Corona_NS2A
#=GF AC PF05213.16
#=GF DE Coronavirus NS2A protein
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_6568 (release 7.7)
#=GF GA 23.00 23.00;
#=GF TC 23.00 23.10;
#=GF NC 22.90 22.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF CL CL0247
#=GF RN [1]
#=GF RM 12466548
#=GF RT Detection of novel members, structure-function analysis and
#=GF RT evolutionary classification of the 2H phosphoesterase
#=GF RT superfamily.
#=GF RA Mazumder R, Iyer LM, Vasudevan S, Aravind L;
#=GF RL Nucleic Acids Res 2002;30:5229-5243.
#=GF DR INTERPRO; IPR039573;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family contains a number of corona virus non-structural
#=GF CC proteins of unknown function. The family also includes a
#=GF CC polymerase protein fragment from Berne virus and does not seem
#=GF CC to be related to the Pfam:PF04753 Coronavirus NS2 family. This
#=GF CC family is part of the 2H phosphoesterase superfamily [1].
#=GF SQ 14
#=GS C0KYT9_9BETC/14-265 AC C0KYT9.1
#=GS B7U2N1_9BETC/4-259 AC B7U2N1.1
#=GS R1AB_BEV/4402-4641 AC P0C6V7.1
#=GS A0A0A7UXA7_9BETC/4-257 AC A0A0A7UXA7.1
#=GS NS2A_CVMA5/2-253 AC P19738.1
#=GS VP3_ROTS1/692-832 AC P15736.2
#=GS Q9PYA1_CVM2/6-257 AC Q9PYA1.1
#=GS R1A_BRV1/4277-4445 AC P0C6F4.1
#=GS Q2QKN5_9BETC/4-193 AC Q2QKN5.1
#=GS A0A0K2RVN0_9BETC/4-193 AC A0A0K2RVN0.1
#=GS VP3_ROTSH/692-832 AC A2T3S5.1
#=GS R1A_BEV/4402-4569 AC P0C6F3.1
#=GS R1AB_BRV1/4277-4517 AC P0C6V8.1
#=GS A7BKC0_9BETC/4-259 AC A7BKC0.1
C0KYT9_9BETC/14-265 ...............................................................................................................AFADKPNHFINFPLAQFSGFMGKYLKLQSQLVEMGLDC...KLQKAPHVSITLL...D.IKADQYKQVEFAIQEII...DDLAAYEG.D..I....VFDNP....HMLGR.CL..VLDV...R...GFEELHEDIVEILRRRGC.TADQSRHWIPHCTVAQF-DEE...RETK.GM.QFYHKEPF.YLKH.NNLLTDAGLELVKIGSSKIDGFYCSELS-----------VWCGER-LCYKPPTPKFSDIFGYCCIDKIRGDLEIGDLPQDDEEAWAELSYHYQRNTYFFRHVHDNSIY--FRTV.............................
B7U2N1_9BETC/4-259 ...............................................................................................................AYADKPNHFINFPLTQFQGFVLNYKGLQFQLLDVGVDC...KIQTAPHISLAML...D.IQPEDYRSVDVAIQEVI...DDMHWGEGfQ..I....KFENP....HILGR.CI..VLDV...K...GVEELHDDLVNYIRDKGC.VADQSRKWIGHCTIAQLTDAA...LSIKeNV.DFINSMQF.NYKItINPSSPARLEIVKLGAEKKDGFYETIAS-----------HWMGIR-FEYNPPTDKLAMIMGYCCLEVVRKELEEGDLPENDDDAWFKLSYHYENNSWFFRYVYRKSSY--FR--ks...........................
R1AB_BEV/4402-4641 ..............................................................................................................v-YADDPTHFLSLPVVN-KNFLAAFYDLQ-----EGFPG...KKQVAPHISLTML...K.LSDEDIEKVE----DIL...DEMVLPNS.W..V....TITNP....HMMGK.HY..VCDV...E...GLDSLHDEVVSVLREHGI.ACDQKRLWKPHLTIGEL-NDV...SFDK.FK.DFAISCKL.----.------EDCDFVKLGAPKANARYEFITTLPLGDFKLLRGAWSACRHLCFQNGAYQSSRSKHYIDLAT---EYNAGIVKVNKSNT---HSVEYQSKRFMIKRVKDQSEFALAKTA.............................
A0A0A7UXA7_9BETC/4-257 ...............................................................................................................AYADKPTHFINFPLSHFNEFVVKFNKLQATILERGVEC...KLQNCPHISVTML...D.IKPSDINSVDIAIQEVI...DDFCFDDA.A..L....TFCNP....HILGR.CI..VLDV...K...GCAELHEDVVEYIREKGC.VADQSRKWIAHCTIAQFTNITpkhLPDG.IK.DLQFNCTI.---P.INQSAPAYLELVELGADKKDGFYKSLVS-----------HWMGIR-SVGKPPTDHLSAIMGYCCLDMIREELPEGSFPEQDDDAWNKLAYHYDNNLWFYRFVFKNSKY--FR--kti..........................
NS2A_CVMA5/2-253 ...............................................................................................................AFADKPNHFINFPLAQFSGFMGKYLKLQSQLVEMGLDC...KLQKAPHVSITLL...D.IKADQYKQVEFAIQEII...DDLAAYEG.D..I....VFDNP....HMLGR.CL..VLDV...R...GFEELHEDIVEILRRRGC.TADQSRHWIPHCTVAQF-DEE...RETK.GM.QFYHKEPF.YLKH.NNLLTDAGLELVKIGSSKIDGFYCSELS-----------VWCGER-LCYKPPTPKFSDIFGYCCIDKIRGDLEIGDLPQDDEEAWAELSYHYQRNTYFFRHVHDNSIY--FRTV.............................
VP3_ROTS1/692-832 ........................................................................................tyaddpnyfigiqfrnipykydv--------------------------------------...---KIPHLTFGVL...H.ISDNMVPDVI-DILKIM...KN-ELFKM.D..I....TTSYT....YMLSDgIY..VANV...S...GVLSTYFKIYNVFYKNQI.TFGQSRMFIPHITLSFN----...----.--.--------.----.------------------------------------------------------------------------------------------------------------------nmrtvriettklqiksiylrkikgdtvfd
#=GR VP3_ROTS1/692-832 pAS ..............................................................................................................................................................*.*.........................................................................................................*.*................................................................................................................................................................................
Q9PYA1_CVM2/6-257 ...............................................................................................................AFADKPNHFINFPLAQFSGVMGKYLKLQSQLVEMGLDC...KLQKAPHVSITML...D.IRADQYKQVEFAIQEVI...DDMAAYEG.D..I....VFDNP....HMLGR.CL..VLDV...K...GFEELHEDIVEILRKRGC.IADQSRQWIPHCTVAQF-EEE...KEIN.EL.QFYYKLPF.YLKH.NNILTDARLELVKIGSSKTDGFYCSELS-----------IWCGER-LCYKPPTPKFSDIFGYCCIDKIRVDLEIGDLPEDDEEAWAELSYHYQRNTYFFRYVHDNSIY--FRTV.............................
R1A_BRV1/4277-4445 ...............................................................................................................AYADEPTHFLSLPVVN-KNFLEAFYELQ-----EGFPG...EKQVAPHISLTML...K.LTEEDVAKVE----DIL...DEMVLPNT.Y..A....TITNP....HMMGQ.YY..VFEV...E...GLQALHDEVVSVLRQHGI.ACDQTRMWKPHLTIGEIKDGS...VFNK.FK.DFGITCKL.----.------EDCDFVKLGAPKANARYEFIATLPVGDL--------------------------------------------------------------------------------nc...........................
Q2QKN5_9BETC/4-193 ..............................................................................................................s-YADNPNHFINFPLTQFDGSVLNYKGLQSQLLDEGVDC...KIQTAPHISLTML...D.IQPEDYISVDVAIQEVI...DDMHWGEGfQ..I....KFDNP....HILGR.CL..VLDV...K...GVEELHDDLVNYIRDKGC.VADQSRKWIGHCTIAQFTDAA...LSIKeNV.DFINSMQF.NYKItINPSSPARLEIVKLGAEKKDGFYETVVSH-------------------------------------------------------------------------------------wmgir........................
A0A0K2RVN0_9BETC/4-193 ...............................................................................................................AYADRPTHFINFPLISFEGFMLNFKDLQFRLLHEGVDC...KLQMVPHVSLAML...D.IVQDQIKCVDTSLQQVI...DGICWDDGfH..I....NFGNP....KILGR.CV..VLEV...K...GLEELHGEIERSISEKGC.VIGQSRPWIAHCTIAQLTDAA..lVINE.NL.DFINSLQFnYTIT.INPASPSRLELVKIGAEKKDGFYKSVVSH-------------------------------------------------------------------------------------wmgir........................
VP3_ROTSH/692-832 ........................................................................................tyaddpnyfigiqfrnipykydv--------------------------------------...---KIPHLTFGVL...H.ISDNMVPDVI-DILKIM...KN-ELFKM.D..I....TTSYT....YMLSDgIY..VANV...S...GVLSTYFKIYNVFYKNQI.TFGQSRMFIPHITLSFN----...----.--.--------.----.------------------------------------------------------------------------------------------------------------------nmrtvriettklqiksiylrkikgdtvfd
#=GR VP3_ROTSH/692-832 AS ..............................................................................................................................................................*.*.........................................................................................................*.*................................................................................................................................................................................
R1A_BEV/4402-4569 ..............................................................................................................v-YADDPTHFLSLPVVN-KNFLAAFYDLQ-----EGFPG...KKQVAPHISLTML...K.LSDEDIEKVE----DIL...DEMVLPNS.W..V....TITNP....HMMGK.HY..VCDV...E...GLDSLHDEVVSVLREHGI.ACDQKRLWKPHLTIGEL-NDV...SFDK.FK.DFAISCKL.----.------EDCDFVKLGAPKANARYEFITTLPLGDL--------------------------------------------------------------------------------nc...........................
R1AB_BRV1/4277-4517 ...............................................................................................................AYADEPTHFLSLPVVN-KNFLEAFYELQ-----EGFPG...EKQVAPHISLTML...K.LTEEDVAKVE----DIL...DEMVLPNT.Y..A....TITNP....HMMGQ.YY..VFEV...E...GLQALHDEVVSVLRQHGI.ACDQTRMWKPHLTIGEIKDGS...VFNK.FK.DFGITCKL.----.------EDCDFVKLGAPKANARYEFIATLPVGDFKLLRDVWCACRHLCFQNGAYQSSRSKHYIDLAT---EYNAGIVKVNKSNT---HSVEYKGQRFMIKRVKDQHEFALARTA.............................
A7BKC0_9BETC/4-259 ...............................................................................................................AYADKPNHFINFPLTQFEGFVLNYKGLQFQLLDEGVDC...KTQTAPHISLAML...D.IQPEDYRSVDVAIQEVI...DDMHWGEGfQ..I....KFDNP....HILGR.CI..VLDV...K...GVEELHDDLVNYIRDKGC.VADQSRKWIGHCTIAQLTDAA...LSIKeNV.DFINSMQF.NYKItINPSSPARLEIVKLGAEKKDGFYETIVS-----------HWMGIR-FEYNPPTDKLAMIMGYCCLEVVRKELEEGDLPENDDDAWFKLSYHYENNSWFFRHVYRKSSY--FR--ks...........................
#=GC seq_cons ...............................................................................................................AYADcPsHFlshPlsp.psFhhtahcLQ......Ghss...KhQpAPHlSlTML...c.Ips-phppV-.sI.-ll...D-hshscu.p..I....shsNP....HMLG+.ph..VhDV...c...Gl-pLH--lVsllRc+Gh.ssDQSRhWIPHhTIuph.-ts...h..K..h.DFh.shph............tch-hVKlGA.KtsuhYc.lso...................................................................................................................
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