#=GF ID Crystall_4
#=GF AC PF17945.5
#=GF DE Beta/Gamma crystallin
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF00195
#=GF GA 30.00 30.00;
#=GF TC 36.90 39.30;
#=GF NC 27.20 21.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF WK Crystallin
#=GF CL CL0333
#=GF RN [1]
#=GF RM 22483117
#=GF RT Structural insight into the bacterial mucinase StcE essential to
#=GF RT adhesion and immune evasion during enterohemorrhagic E. coli
#=GF RT infection.
#=GF RA Yu AC, Worrall LJ, Strynadka NC;
#=GF RL Structure. 2012;20:707-717.
#=GF DR INTERPRO; IPR040966;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is the C-terminal domain found in mucin glycoproteins such
#=GF CC as secreted protease of C1 esterase inhibitor from EHEC (StcE).
#=GF CC This domain adopts a beta/gamma crystallin fold and has been
#=GF CC shown to be dispensable for substrate binding. Furthermore,
#=GF CC deletion analysis suggest that lack of the C-terminal resulted
#=GF CC in impaired association with the cell surface [1].
#=GF SQ 53
#=GS A0A0B2X0M1_METAS/291-380 AC A0A0B2X0M1.1
#=GS Q1LIQ7_CUPMC/286-375 AC Q1LIQ7.1
#=GS A0A545UZH8_9HYPO/291-379 AC A0A545UZH8.1
#=GS A0A2V4NGJ0_VIBCL/29-118 AC A0A2V4NGJ0.1
#=GS A0A0A2VZ22_BEABA/387-476 AC A0A0A2VZ22.1
#=GS Q9KTH2_VIBCH/126-215 AC Q9KTH2.1
#=GS STCE_ECO57/807-896 AC O82882.2
#=GS A0A0B6S625_BURPL/321-416 AC A0A0B6S625.1
#=GS A4JE97_BURVG/278-367 AC A4JE97.1
#=GS A0A545WBV9_9HYPO/293-382 AC A0A545WBV9.1
#=GS A0A179IQ94_CORDF/387-476 AC A0A179IQ94.1
#=GS A0A2A5T4G2_9GAMM/319-408 AC A0A2A5T4G2.1
#=GS C5AGQ3_BURGB/319-414 AC C5AGQ3.1
#=GS A0A545WBV9_9HYPO/389-477 AC A0A545WBV9.1
#=GS A0A2N6N8D0_BEABA/387-475 AC A0A2N6N8D0.1
#=GS Q9KTH2_VIBCH/29-118 AC Q9KTH2.1
#=GS A0A0B6S625_BURPL/423-512 AC A0A0B6S625.1
#=GS E3BMX4_9VIBR/130-218 AC E3BMX4.1
#=GS A0A2A5T4G2_9GAMM/31-120 AC A0A2A5T4G2.1
#=GS A0A0A2VZ22_BEABA/291-380 AC A0A0A2VZ22.1
#=GS A0A0A2VB51_BEABA/291-380 AC A0A0A2VB51.1
#=GS A0A2V4NGJ0_VIBCL/126-215 AC A0A2V4NGJ0.1
#=GS A0A0B2X0M1_METAS/387-476 AC A0A0B2X0M1.1
#=GS J4UQ17_BEAB2/291-380 AC J4UQ17.1
#=GS A0A6S7C1J0_9BURK/291-380 AC A0A6S7C1J0.1
#=GS A0A166WM82_METRR/294-383 AC A0A166WM82.1
#=GS C5AGQ3_BURGB/421-510 AC C5AGQ3.1
#=GS U4KDF4_9VIBR/34-123 AC U4KDF4.1
#=GS A0A545UZH8_9HYPO/386-475 AC A0A545UZH8.1
#=GS J4VZK5_BEAB2/291-380 AC J4VZK5.1
#=GS A0A168DY11_CORFA/388-477 AC A0A168DY11.1
#=GS A0A1T4WEV6_9GAMM/36-65 AC A0A1T4WEV6.1
#=GS Q1LIQ7_CUPMC/382-471 AC Q1LIQ7.1
#=GS A4JE97_BURVG/374-463 AC A4JE97.1
#=GS U4KDF4_9VIBR/131-220 AC U4KDF4.1
#=GS A0A168DY11_CORFA/292-381 AC A0A168DY11.1
#=GS A0A2N6N8D0_BEABA/291-380 AC A0A2N6N8D0.1
#=GS A0A0D9P4Z6_METAN/279-368 AC A0A0D9P4Z6.1
#=GS A0A6S7C1J0_9BURK/387-476 AC A0A6S7C1J0.1
#=GS A0A179IQ94_CORDF/291-380 AC A0A179IQ94.1
#=GS J4UQ17_BEAB2/387-475 AC J4UQ17.1
#=GS A0A2N6N9P3_BEABA/387-476 AC A0A2N6N9P3.1
#=GS E9EF41_METAQ/383-472 AC E9EF41.1
#=GS A0A2A5T4G2_9GAMM/223-312 AC A0A2A5T4G2.1
#=GS J4VZK5_BEAB2/387-476 AC J4VZK5.1
#=GS A0A0A5HXA6_PHOS4/29-118 AC A0A0A5HXA6.1
#=GS A0A166WM82_METRR/390-479 AC A0A166WM82.1
#=GS A0A2N6N9P3_BEABA/291-380 AC A0A2N6N9P3.1
#=GS E9EF41_METAQ/287-376 AC E9EF41.1
#=GS E3BMX4_9VIBR/33-122 AC E3BMX4.1
#=GS A0A2A5T4G2_9GAMM/127-216 AC A0A2A5T4G2.1
#=GS A0A0D9P4Z6_METAN/375-464 AC A0A0D9P4Z6.1
#=GS A0A0A2VB51_BEABA/387-475 AC A0A0A2VB51.1
A0A0B2X0M1_METAS/291-380 GCIVSLRTSARYCLSADQEA...EYSLPPW...IYE.HDVYVDAAPGTAVQLSD...FDNLS...YHR.IATFVGTVDNGRLKSVRAANGVLLDFSRPHSMRVV..
Q1LIQ7_CUPMC/286-375 GCIISLRNGAKYCLEAGQKS...DYSLPAW...IYA.HDVYVQADSGVSVVLSD...WDNLS...YHR.LAEFVGTVENDKLRGVKANNGETLDFSKPRSMEV-k.
A0A545UZH8_9HYPO/291-379 GCIINTATSERYCLPPGH-A...ADSLPKW...IYG.KPVYVDAAPGTAVELCD...FENLS...YGR.IARFEGTVEHENLKSVAAESGETLDFSRPHSMRV-k.
A0A2V4NGJ0_VIBCL/29-118 GCIISRLNGEKYCLKVGERS...GYSLPSW...IYA.HPVDVQAPSGVSVMLSD...WDNLS...YNR.LAVFDRYTGNEDLKNVKAYNGAYLDFSKPRSMRVL..
A0A0A2VZ22_BEABA/387-476 GCIFGLTSGRKYCLPAGQRS...GYELPGW...ISG.LDVQVQPASGAKVTLCD...WANLS...YNR.LATFDSFVQNWELKNVTAANGQMLDFSRPKSMRV-s.
Q9KTH2_VIBCH/126-215 ACIVSRQTGERFCLKEGERS...GYSLPAY...IYG.HEVDVEAPLGLGVMLSD...WDNLS...YNR.LAVFGGNTQNEQMRAVKAYNGETLDFSKPRSMRVV..
STCE_ECO57/807-896 GCIVSVNSGKRYCLPVGQRS...GYSLPDW...IVG.QEVYVDSGAKAKVLLSD...WDNLS...YNR.IGEFVGNVNPADMKKVKAWNGQYLDFSKPRSMRVV..
A0A0B6S625_BURPL/321-416 ACLVNVQFGTQYCLPAGQESyngDRKWPVL...FSG.WDVRVQADDGVAVRLST...NPRLDaagIGK.SAQFFGTTDTDRLRHVKANNGEYLNFSQPNAMRV-t.
A4JE97_BURVG/278-367 GCIVSLQTAARYCLPVGQRS...GYALPSW...IYA.HDVFVDAAPGTAVMLSD...WDNLS...YNR.IATFVGTVENGGLKQVKAVNGQVLDFSRPHSMRVV..
A0A545WBV9_9HYPO/293-382 GCIVSVKTNDAYCLTVGQSS...GYSLPSW...IYD.QQVYVRADPGTAVQLSD...YDNLS...YNR.LAKFDGTVENSQLKAVKANNGQTLDFSHPHSMRVV..
A0A179IQ94_CORDF/387-476 GCIVSLTSVKKYCLPAGQRS...GYSLPSW...IYA.QEVQVEAVPGAAVMLSD...SDDLS...YNR.IATFNGLVQNWELKRVKAANGEELDFSRPKSMRVL..
A0A2A5T4G2_9GAMM/319-408 GCIVSLETNAKYCSTVFWMG...RHKLPSW...IYE.HKISIQAAGGAAVAISE...RERLP...YQH.TVTFAGTVASKDINLIRADNYQLFDLSKPTYIEVV..
C5AGQ3_BURGB/319-414 ACLVNALFGVKYCLSEGQES...YNGDGKWtvmFSG.MDLGVQADDGVAVQLSTdrrMDAVG...SGK.SAEFVGTVESSRLKHVKANDGQYRDFSRPNAMRV-r.
A0A545WBV9_9HYPO/389-477 GCIVSLTSVELYCLPKGKSA...GYSLPSR...IYG.HDVQAEGS-AAGVMLSD...WDNLS...YNR.IATFNKLVQNWELKKVRAVNGEVLDFSRPKSMRVV..
A0A2N6N8D0_BEABA/387-475 GCITALATVDRFCLPTGQKA...-LVLPAW...IIQ.TEVQVEAVAGAAVTLCD...FENLS...YNR.LARFTGFMQNWDLKSVTAANRAVLDFSRPRSMKV-s.
Q9KTH2_VIBCH/29-118 GCIISRLNGEKYCLKVGERS...GYSLPSW...IYA.HPVDVQAPSGVSVMLSD...WDNLS...YNR.LAVFDRYTGNEDLKNVKAYNGAYLDFSKPRSMRVL..
A0A0B6S625_BURPL/423-512 GCIVSLDSAQKYCLPAGQPA...VGQLPAW...IKG.QAVFVQADPGVAVRLSD...RADFA...YNR.VATFSGTVDHDKLLKVRADNGEDLDFSRPVSMEVI..
E3BMX4_9VIBR/130-218 ACVISRLNGAEFCLKPEHRN..rKWFLPFY...MWG.HPVDVLAPEGLAVQLK-...-NKWS...HHRsWATVTTDTNNEDLTRVRTHHGY-ANVSRPFWMRVI..
A0A2A5T4G2_9GAMM/31-120 GCIVSLESNERYCLPVGQRS...GYSLPDW...ING.HEVYVQASEGAAVMLSD...MDNLS...YHR.LAIFSGTVTNQQLINVGAINGDRLNLSNPRSMRVV..
A0A0A2VZ22_BEABA/291-380 GCIVNIDNDDKYCLQAGERS...PYSLPSW...IYN.KQVYVDAAPGTAVVLSD...WDNLS...YNR.LARFEGTVENDRLKAVKADNGETLDFSHPKSMRVV..
A0A0A2VB51_BEABA/291-380 ACIVSTQTNDRYCMSPGDKA...EYALPEW...IRG.HTVRVDAGPGTAVELCD...MDNLS...YNR.VAKFVGSVDNSTLKAVKANNGETLDFSRPHSMRVL..
A0A2V4NGJ0_VIBCL/126-215 ACIVSRQTGERFCLKEGERS...GYSLPAY...IYG.HEVDVEAPLGLGVMLSD...WDNLS...YNR.LAVFGGNTQNEQMRAVKAYNGETLDFSKPRSMRVV..
A0A0B2X0M1_METAS/387-476 GCITSLLSGARYCLPPGQRS...GYSLPAW...IYA.HDVQVHAAPGTAVMLSD...VENLA...YHR.FASFTGFVQNWELTKVRARNGKHVDFSRPRSMRVI..
J4UQ17_BEAB2/291-380 ACIVSTQTNDRYCMSPGDTA...EYALPKW...IRG.HTVRVDAGPGTAVELCD...MDNLS...YNR.VAEFVGSVENAALKAVKANNGETLDFSRPHSMRVV..
A0A6S7C1J0_9BURK/291-380 GCIVSLRSGAKYCLKAGARS...GYSLPDW...IYS.QNVYVQADSGVSVMLSD...WDNLS...YAR.TALFYGTTENSKLKHVKADNGEYLDFSMPRSMRVV..
A0A166WM82_METRR/294-383 GCIVSMDSGARYCMTAGQKA...AYSLPAW...ING.HNVSVDAAPGTAVKLSD...FDALS...YNR.VASFVGTVGTDGLRKVRAANGQDLDFSRPKSMGV-t.
C5AGQ3_BURGB/421-510 GCIVSLDSAQKYCLPAGQQP...VQQLPAW...IKG.QDVFVQADQGVAVRLSD...RPNFA...YNR.VATFSGTVSHDKLIKVRADNGEDLDFSRPVSMEVI..
U4KDF4_9VIBR/34-123 ACIVSRDTGAKYCLQAGQRS...GYSLPSY...IRG.HDVDVIAPEGLGVMLSD...WDNLS...YNR.LAVFERHTHNEAMEHVLARNGQYLDFSNPRSMRVV..
A0A545UZH8_9HYPO/386-475 GCITELTTCNKYCLPAGKEC...NF-FPSW...FDTvGGVQVEALPGAQVTLSD...FQDLS...HGH.LATFPGFVQNWELRSVKAENGQELDFSKPQSMRV-t.
J4VZK5_BEAB2/291-380 GCIVNIDNDDKYCLQAGERS...PYSLPSW...IYN.KQVYVDAAPGTAVVLSD...WDNLS...YNR.LARFEGTVENDRLKAVKADNGETLDFSHPKSMRVV..
A0A168DY11_CORFA/388-477 GCIFGLTSGDKYCLPAGQRS...GYELPAW...ISG.LDAQAQPAPGARVQLCD...WANLS...YNR.LATFDQFTQNWELRNVTAANGQVLDFSRPRSMRVL..
A0A1T4WEV6_9GAMM/36-65 GCIVSLETGAEYCLPVGQRS...GYSLPSW...I--.-----------------...-----...---.-----------------------------------gf
Q1LIQ7_CUPMC/382-471 GCIVSLVSVDKYCLPAGERS...AYSLPAW...IYA.HDVVVQADAGIGVMLSD...WDNLS...YNR.LAVFSDVVENENMKRVQAYDGQTLDFSKPRSMRVV..
A4JE97_BURVG/374-463 GCIVSLTSGAKYCLPAGQRS...GRALPSW...IYA.NEVQVEAAAGIAVMLSD...TDDLA...FNR.VATFTGLTQNWELKKAKAWNGEDLDFSRPKSMRVV..
U4KDF4_9VIBR/131-220 ACIVSRQTGAEYCLKAGQRS...GYSLPYY...IRG.HQVDVIAPEGLAVMLSD...WDNLS...YNR.LAVFTKDTNNEDMKNVRAYNGRYLDFSHPRSMRVL..
A0A168DY11_CORFA/292-381 GCIVKVETGDRYCLPAGERS...PYSLPKE...FWN.QQVYVDAAPGTAVTLCD...WDNLS...YNR.LATFDGTVENDRLKAVKAANGETLDFSHPKSMRVV..
A0A2N6N8D0_BEABA/291-380 ACIVSTQTNDRYCMSPGDKA...EYALPEW...IRG.HTVRVDAGPGTAVELCD...MDNLS...YNR.VAKFVGSVDNSTLKAVKANNGKTLDFSRPHSMRVL..
A0A0D9P4Z6_METAN/279-368 GCIVSLHTKARYCMSAGTTP...VSSLPRW...IYE.HEIYVDAAPGTAVKLSD...FDNLS...YNR.IATFVGTVENNRLKSVKAANGKYLDFSRPHSMRVV..
A0A6S7C1J0_9BURK/387-476 GCIVSLISAEKYCLPAEDRS...GYELPNW...IKG.HDVFVQADHGVAVMLSD...WDNLS...YSR.VATFSGVVEHEDLKHVRAQNGEDLDFSHPFSMRVI..
A0A179IQ94_CORDF/291-380 GCIVSLQTNDSYCLSAGERS...PYSLPAW...IYN.HQVYVDAAPGTAVVLSD...YDNLL...HNR.LATFVGTVENDKLKAVKAANGETIDFSYPKSMRV-q.
J4UQ17_BEAB2/387-475 GCITALATVDRFCMPAGQKA...-LALPAW...IIQ.TEVQVEAVAGAAVTLCD...FENLS...YNR.LATFTGFVQNWDLKRVTAANKAVLDFSRPRSMKV-s.
A0A2N6N9P3_BEABA/387-476 GCIFGLTSGRKYCLPAGQRS...GYELPGW...ISG.LDVQVQPASGAKVTLCD...WANLS...YNR.LATFDSFVQNWELRNVTAANGQMLDFSRPKSMRV-s.
E9EF41_METAQ/383-472 GCITSLITSARYCLPPEQQS...SDSLPPW...IYA.HDVQVEAAPGTAVILSD...SNNLS...HKR.LATFTGFIQNWELTKVRALNGEDVDFSRPKSMRVI..
A0A2A5T4G2_9GAMM/223-312 GCIISLESNDRFCLPVGQSS...GYALPNW...IKG.HEIYVQASQGAGVMLSN...WYDLT...DTN.VTAFAGTVNNQDLVSRRAVSGKEMDFSAPFSMKVV..
J4VZK5_BEAB2/387-476 GCIFGLTSGRKYCLPAGQRS...GYELPGW...ISG.LDVQVQPASGAKVTLCD...WANLS...YNR.LATFDSFVQNWELKNVTAANGQMLDFSRPKSMRV-s.
A0A0A5HXA6_PHOS4/29-118 GCIVSKETGDKYCLNVGERS...GYSLPSF...IYE.HEVDVYAGAGAGVMLSD...WDNLS...YNR.LAVFTGYTPNSELEAVKAYNGKVLDFSAPRSMRVV..
A0A166WM82_METRR/390-479 GCIVSLTSCARYCLPAGQGS...GYSLPSW...VKA.HEVQVEAASGTAVVLSD...FENLA...YNR.LATFDGFVQNWELKKVKAENGQDLDFSRPKSMRVV..
A0A2N6N9P3_BEABA/291-380 GCIVNIDNDDKYCLQAGERS...PYSLPSW...IYN.KQVYVDAAPGTAVVLSD...WDNLS...YNR.LARFDGTVENDRLKAVKADNGETLDFSHPKSMRVV..
E9EF41_METAQ/287-376 GCIVSLQTSARYCLSAGNTS...GYSLPRW...IYE.HEVYVDAAPGTAVQLSD...FDNLS...YKR.IATFVGTVENNRLKSAKAASGKYLNFSRPHSMRVV..
E3BMX4_9VIBR/33-122 ACIVSRDTGAKYCLEAGQSS...GYSLPSY...IYG.HEVDVIAPDGLAVQLSD...WDNLS...YNR.VATFSRHTHNKALRRVRARNGHYLDFSNPRSMRVI..
A0A2A5T4G2_9GAMM/127-216 GCIISLKTKDKYCLPVGKSS...DSSLPSW...IKG.HSVYVQASAGTAVMLSG...LNNLS...SDH.LATFSGTVTNDKLIAVKALNGETLNFSTPHSMRVV..
A0A0D9P4Z6_METAN/375-464 GCITSLTTSASYCLPAEQQS...EGSLPSW...IYA.HDVQVEAAPGTAVILSD...SDNLP...QDR.LATFTGFVQNWDLTKVRALNGEDLDFSRPKSMRVI..
A0A0A2VB51_BEABA/387-475 GCITALATVDRFCLSAGQKA...-LVLPAW...IIQ.TEVQVEAVAGAAVTLCD...FENLS...YNR.LARFTGFMQNWDLKSVTAANRAVLDFSRPRSMKV-s.
#=GC seq_cons GCIVSlpous+YCLssGp+S...sYSLPuW...Ihu.+-V.VpAssGsAVhLSD...aDNLS...YNR.lAsFsGsVpNpcL+pV+AtNGphLDFS+P+SMRVl..
//
