#=GF ID   Csa1
#=GF AC   PF06023.16
#=GF DE   CRISPR-associated exonuclease Csa1
#=GF PI   DUF911;
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_8782 (release 9.0)
#=GF GA   27.00 27.00;
#=GF TC   27.30 27.10;
#=GF NC   26.80 26.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   22408157
#=GF RT   Characterization of the CRISPR/Cas subtype I-A system of the
#=GF RT   hyperthermophilic crenarchaeon Thermoproteus tenax.
#=GF RA   Plagens A, Tjaden B, Hagemann A, Randau L, Hensel R;
#=GF RL   J Bacteriol. 2012;194:2491-2500.
#=GF DR   INTERPRO; IPR009260;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   CRISPR (clustered regularly interspaced short palindromic
#=GF CC   repeats) elements and cas (CRISPR-associated) genes are
#=GF CC   widespread in Bacteria and Archaea. The CRISPR/Cas system
#=GF CC   operates as a defense mechanism against mobile genetic elements
#=GF CC   (i.e., viruses or plasmids). Csa1 is part of the archaeal
#=GF CC   subtype I-A system. Cas1 has not yet been enzymatically
#=GF CC   characterised [1].
#=GF SQ   71
#=GS B1L401_KORCO/2-309       AC B1L401.1
#=GS A0A4R1BEZ2_9ACTN/1-284   AC A0A4R1BEZ2.1
#=GS E1QQW1_VULDI/1-189       AC E1QQW1.1
#=GS A0A0U2U6Q3_9CREN/4-109   AC A0A0U2U6Q3.1
#=GS Q96X76_SULTO/1-279       AC Q96X76.1
#=GS A2BKJ7_HYPBU/2-270       AC A2BKJ7.1
#=GS F4BVL1_METSG/1-313       AC F4BVL1.1
#=GS A0A4Y7RV06_9FIRM/1-306   AC A0A4Y7RV06.1
#=GS D3RZS6_FERPA/1-310       AC D3RZS6.1
#=GS H2C0Y0_9CREN/1-293       AC H2C0Y0.1
#=GS A0A3N5AP42_9THEO/1-306   AC A0A3N5AP42.1
#=GS A0A2T9WWH0_9CREN/9-266   AC A0A2T9WWH0.1
#=GS A0A2H5UZT8_9ARCH/3-299   AC A0A2H5UZT8.1
#=GS H9ZZA3_FERFK/2-297       AC H9ZZA3.1
#=GS K8DY73_9FIRM/1-303       AC K8DY73.1
#=GS A0A6N7IM04_9FIRM/1-309   AC A0A6N7IM04.1
#=GS Q8ZZL7_PYRAE/1-280       AC Q8ZZL7.1
#=GS A8ABK7_IGNH4/16-109      AC A8ABK7.1
#=GS A0A0M2U345_9FIRM/1-306   AC A0A0M2U345.1
#=GS H2C4W1_9CREN/12-295      AC H2C4W1.1
#=GS A0A2U9IJ08_9CREN/1-284   AC A0A2U9IJ08.1
#=GS A3DLB8_STAMF/1-310       AC A3DLB8.1
#=GS E1QU80_VULDI/3-265       AC E1QU80.1
#=GS G0EGJ8_PYRF1/4-289       AC G0EGJ8.1
#=GS A0A023X6Y1_9ACTN/1-284   AC A0A023X6Y1.1
#=GS A0A031LIY4_9CREN/1-295   AC A0A031LIY4.1
#=GS L0K8Q1_HALHC/1-305       AC L0K8Q1.1
#=GS F4B6T2_ACIHW/1-283       AC F4B6T2.1
#=GS B0TFX6_HELMI/1-310       AC B0TFX6.1
#=GS F4B5P8_ACIHW/1-293       AC F4B5P8.1
#=GS A0A2H5V0A7_9ARCH/6-307   AC A0A2H5V0A7.1
#=GS D5U1T3_THEAM/41-321      AC D5U1T3.1
#=GS A0A7G6E237_9FIRM/1-306   AC A0A7G6E237.1
#=GS A0A830GW72_9CREN/1-304   AC A0A830GW72.1
#=GS Q9YCL7_AERPE/84-260      AC Q9YCL7.2
#=GS Q9YCL7_AERPE/1-90        AC Q9YCL7.2
#=GS A0A348B575_9CREN/1-300   AC A0A348B575.1
#=GS E0STX3_IGNAA/124-297     AC E0STX3.1
#=GS C9R974_AMMDK/1-307       AC C9R974.1
#=GS A4YFV5_METS5/1-272       AC A4YFV5.1
#=GS S5Z705_9CREN/14-115      AC S5Z705.1
#=GS K4LGE4_THEPS/1-307       AC K4LGE4.1
#=GS CSA1_SACS2/1-291         AC Q97YD4.1
#=GS A0A4R8HFU4_9FIRM/1-305   AC A0A4R8HFU4.1
#=GS O28400_ARCFU/1-281       AC O28400.1
#=GS A0A2V3JM66_9EURY/2-257   AC A0A2V3JM66.1
#=GS A0A7L9FLB2_9CREN/3-261   AC A0A7L9FLB2.1
#=GS B8D4S8_DESA1/1-280       AC B8D4S8.1
#=GS I3TFC8_THEC1/4-283       AC I3TFC8.1
#=GS A8ABK7_IGNH4/106-249     AC A8ABK7.1
#=GS A0A5Q2N509_9FIRM/1-307   AC A0A5Q2N509.1
#=GS A0A2H5UZ86_9ARCH/2-69    AC A0A2H5UZ86.1
#=GS A0A510DYE0_9CREN/1-287   AC A0A510DYE0.1
#=GS Q97Y83_SACS2/1-281       AC Q97Y83.1
#=GS A0A0U2U6Q3_9CREN/92-237  AC A0A0U2U6Q3.1
#=GS Q977B6_SULTO/1-288       AC Q977B6.1
#=GS S5ZDL3_9CREN/1-117       AC S5ZDL3.1
#=GS A0A4R2RGP8_9FIRM/1-312   AC A0A4R2RGP8.1
#=GS E0SSI5_IGNAA/1-240       AC E0SSI5.1
#=GS A0A2H5V4I6_9ARCH/1-313   AC A0A2H5V4I6.1
#=GS CSA1_THETK/1-278         AC G4RJY8.1
#=GS K0ICJ6_NITGG/1-318       AC K0ICJ6.1
#=GS A1HNE2_9FIRM/1-306       AC A1HNE2.1
#=GS Q8ZZU0_PYRAE/1-286       AC Q8ZZU0.1
#=GS E0STX3_IGNAA/31-131      AC E0STX3.1
#=GS W7KGY0_9CREN/1-268       AC W7KGY0.1
#=GS F6B8W8_DESCC/1-303       AC F6B8W8.1
#=GS B1I4M0_DESAP/7-311       AC B1I4M0.1
#=GS A0A0F7FGX1_9CREN/4-310   AC A0A0F7FGX1.1
#=GS D9PZC8_ACIS3/1-262       AC D9PZC8.1
#=GS A0A2R4ZSS2_9CREN/7-298   AC A0A2R4ZSS2.1
B1L401_KORCO/2-309                  ...................................................yyvdpv------EV..KKL.sRDLLPASRERPVDERLRGWNWFQSPLRPYSSeVPLGVWEIASSICPTGRDVWIRhKVLRRSVP..TT.P.QIA....KGIVVHRLVSSMFLKAKKMVYM.G.K.Y.EL....RDD....L.....-........IT...E...S..EGIV...........eRELENMRKyvklpd.....eeglrgFCRRIARWE..AT..RIE..GKVMEVR...AKY....PFLNEE...S..LVQIA......FP..V.A.TELAID.GSLLGLSQYLRADAAWIFGG.......I.L.F..DVK.T......DR.....KED.....W.....HRIQLAGYALAFESFF.EMPVDIGCVVYV.sEV.PEGL...RVFRDFF....LITDDLR.SRFLERRDELQMMLIREDE...P.K..RA.E...RCP.KY..CLFSDMCG--vv.......................................
A0A4R1BEZ2_9ACTN/1-284              ...................................................mfmpta----EEKK..RLL..RGTIPRARKLGVDDTLRGWSWSAPPLLSPYE.VPLGLSEVANAYCATGRDIYAR.RVLGAETE..PN.E.KMI....LGSALHSTLREWTVHAKRKLYE.S.G.A.ED....IER....A.....-........-V...R...-..-EIR............AFPEPDLP.................EARSLVAYE..AD..AIE..FRLREAI...SQF....PRIGTD...A..LVAQV......LP..V.T.LGQMLD.GAFLGLSRRLSTDLLNLGEP.......A.V.L..NII.F.....nDE.....KRS.....F.....HPLTLAGYALVLEAVY.EFPVDVGVTVYA..SFrNGRL...QIEREFA....VLGDELR.MEFIEVRDEKQRMVADELD...P.G..PC.E...ECE.AW..C---------s........................................
E1QQW1_VULDI/1-189                  ......................................................mlg--------..RLL..DRVKVF-GVGDLPVELRGWSQEVREVSLE--.YLPTVSEAF-SPCPTHRDVYVR.RVLRLQPR..IN.D.SLS....IGRALHELFLTPLRLVNRVGAG.D.V.-.--....IEE....L.....S........NL...K...A..QLLS............DLTKDLVD.................FGKVVFEAS..SR..ILM..DLVYD--...---....------...-..--GYP......IP..I.A.VEPSLE.GTVIGFSDVIKPDLVIGSLP.......VeV.V..VSE.N......PD.....YLA.....R.....KELALA----------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------dvv......................................
A0A0U2U6Q3_9CREN/4-109              .........................................rsvwdelrasageamv--------..---..--------------TVRGWDWSL--LQNRAP.VKPTVSEVT-SPCPTKRDSYLR.RVLGARPS..-S.P.LLE....KGKMVHEAFMSPFRGEEREFKE.E.L.L.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------...---....------...-..-----......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-.....----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------kkvheeaklrkaiade.........................
Q96X76_SULTO/1-279                  .....................................................miwr--------..QQL..KRLHRIREMDPVPDELRGWHYYSPPVKPKAY.LGLTMGEIAYDYCPTKRDVYVR.RVLNQKGS..ER.A.QLV....FGQAIHKVFSKALNDVRISYVL.G.K.DpYQ....IVK....E.....-........SY...L...E..SE--............FCPQEISE.................YCRKVYGNL..IL..FWS..SWLAEAK...---....AFYGGD...S..VGF--......LP..W.A.TEVRVD.GSAIGLSDRLTVDA--LGEF.......T.V.V..EVK.S......GK.....REE.....F.....HKLALAGYALAIESVL.ELPVDYGLLVYI.nGF.PNDV...EIKFESY....YISPDMR.REILDKRDEIIEMVLNGRD...P.G..KP.V...KCP.ET..CPFYEVC---wk.......................................
A2BKJ7_HYPBU/2-270                  ...............................................vlprrvwdyi--------..---..---RSLGSEGPVYAEIRGWRFDY--VAPRYR.YRPSVSEVA-SYCPSHRDAYLQ.HVRGLQPP..RS.L.RAQ....YGVLVHEFFLEPFRLVDRGADS.L.E.A.LT....AGK....Y.....R........LA...R...-..-RLG............VRADRFLE.................RVYELGAI-..--..---..-------...---....--LALQ...S..RVDGD......IP..L.R.VEPPIP.GAPVGLSDTVRPDLLVGFIPv.....eV.T.A..AGP.W......GT.....YGS.....K.....KELQLAGYALAIEAWT.GIPVDYGVVVYV.tRR.SDEP...RPEWRVV....VIDDALR.RSFLRERDEVAMIVENRVD...P.G..PAgE...GCP.SW..CPFRG-----vegcp....................................
F4BVL1_METSG/1-313                  ...................................................myffse-----EER..KYL.lKKLIPSTRERGIAEDLRGWNWHCSELSPPHD.ILMPVWEVSDRYCETGRDTYLR.HVQKVSVP..AS.E.EMV....AGRIYHQAMAELYPTAKRLIYK.EgM.S.IC....AEL....P.....G........IL...MerlD..DAIV............EANEQLSQtkfspsa..eagqsvsdNLRKLWSFE..VS..RIV..SSIFAYL...AKY....KYLSDD...S..LINHA......LP..F.V.VEHKLD.GKYLGLSRNLSADAINMGGM.......L.I.C..DLK.T......GQ.....KRD.....F.....HRLSATGYALVYESLY.EVPINIGCTVYL..SF.PKNHptpHIERDFF....IISDEVR.QWFIEERDSKQDLIFYERD...P.G..RC.P...N-P.GS..CRYREFC---f........................................
A0A4Y7RV06_9FIRM/1-306              .................................................myfltdee------RK..QLL..KNLLPRSRQMETAEELRGWNWHQPPLAPVYD.IKLALYEVANSYCNTGRDLYLR.RVDRIKAK..PN.L.AMI....RGKIFHEILVRVLVRAKRLIYE.K.G.V.GN....FQE....I.....I........KK...L...N..TPLDlsfl...seyqsRLQ----Edefv.........elqrKSAIIAAFE..NA..RVS..ARIQEIL...IKQ....PYIAED...S..LAALA......IP..V.V.VEQKLD.GTFLGLSANLSADAFTFSEP.......M.V.L..DLK.F......GE.....PKK.....F.....HRLTTTGYALVMEAIH.EFPVNLGCLVYA..EF.KGDR..lVVKKDIH....IIDDELR.QWFIEERDNKMRMIYEEID...P.G..YG.-...ECR.DH..CPYILQCR--g........................................
D3RZS6_FERPA/1-310                  ..................................................myyldvi------EV..KRL.tRDLLPRVRENQIDERLRGWNWFESPVRPYSDeLLLPVWDVATSICPTKRDAWIRhKILKRSVP..TT.I.QQA....KGFIVHKIISSMFLKAKKLVYL.G.Y.E.EL....RDE....L.....I........KS...A...E..ENLKmel......gemS------Knleirek...dveelkdFCMKIAKWQ..AT..RIE..SKVLEVK...AKY....PFLNEE...S..LVQLS......FP..I.A.TETVVD.GSLLGLSKYLRADAAWMLGG.......I.I.F..DVK.L......GR.....KED.....W.....HRLQVAGYALAFESVF.ERPVDIGCTVYV.sRA.GEGI...RVDRDFY....IVDDYLR.SSFLEKRDELQMTLLRDVE...P.D..VA.D...KCP.RY..CVFRSYC---lk.......................................
H2C0Y0_9CREN/1-293                  .........................................................MIFTLDQI..ALY.aKRARST--PRSISEELRGWRWNEPPVFPSSS.RTLGVSDVL-STCPTGRDVFLR.YVKWVRSG..TE.-.--P....RGSLIHETYASAVETVKRFIYE.G.V.S.DG....NQ-....L.....R........SS...M...L..EEFY............TFMKRLDKyrdf........pqyleVGRAMWDYV..SS..VYS..SELDRAV...QRS....PFLARD...S..LASMI......VP..F.F.VEYPVD.GSLVGLN-QVRVDAFIPQIP.......M.V.A..EMK.T......GV.....RKK.....-.....YELSLAGYALAYESNF.ETPVDFGLLCYV..KY.EGRI...NVRCDFK....VISDRMR.EEFLEERDKRLEILDKEID...P.G..LP.N...FCD.PH..CPFLSVCGG-k........................................
A0A3N5AP42_9THEO/1-306              .....................................................myff---TDEEK..KHL.lRYHLPRARERGVAEELRGWNWHQPPLEPVYRdVVLALYEVANAYCPTGRDVFLR.RVQREKGR..PN.L.AML....QGAIFHAVVADVIVAAKRAIYG.E.G.V.AN....YRT....I.....V........ER...V...Q..NHPVlpld...awaeqL-----TPeela.........dtasKVEILAAFE..KT..RVL..ARLQEIL...TKQ....PYIGED...S..LVSLA......LP..V.V.VEQKLD.GSFLGLSPNLSTDACVFWEP.......M.V.L..DLK.F......DK.....PRD.....F.....HRLTTTGYALVMEALY.EFPVNLGCIVYG..EF.RGDR..lIVKKDIH....IISDELR.QWFIETRDEKARLVAEEID...P.G..T-.G...DCY.EG..CPYHHVC---fg.......................................
A0A2T9WWH0_9CREN/9-266              .................................................rvlglgdl--------..---..------------PVEVRGWSREVSEVY--YE.YLPTVSETF-TPCPTHRDAYLR.RVVGVKAP..VN.N.SLG....VGRVLHDAFLTPFKAVYRLDAG.S.L.V.EG....---....L.....A........RA...K...G..ELLG............SITNDLVG.................AASVVFDYG..AR..FAM..-D-----...---....--LKLE...S..---FP......LP..V.A.VEPELS.GSLVGFSDVIKPDLVLGMIP.......VeV.V..VSD.N......QD.....YIA.....R.....KEEALAVYAMALEAMW.SNPVNYGILVII..NP.RTA-...SLITRQV....VLTDDVR.RAAIRERDETARIVSRKDD...P.G..SG.G...RCP.QS..CPFYDYCM--ggg......................................
A0A2H5UZT8_9ARCH/3-299              ..............................................fysyddllris--------..---..KTIQEM--PCDVSDELRGWRWSDPPLLPVYS.VKINASDLS-FSCGTGRLAFLR.HSLRVGEK..AG.E.GLR....FGAFVHQVISAATANAKAIMYC.S.K.P.SN....GVE....F.....F........EI...M...S..RTMYscv......qvdGLTEDYVN.................ALNTLWSRA..AL..TYS..SAYDRIL...ETS....KYLSVD...G..LVGRV......VP..W.I.CEFPVD.GRLLGLSRAIRLDA-LAPPA.......L.I.V..EFK.T......RK.....PSR.....E.....FEVALTGYALCFESQY.KIPVNYAVILYI..EF.NHSKtsfKVYENIV....RIDDEVR.LRFVEKRDLYAQIASAKVD...P.G..LP.V...ECD.AY..CPFLRVCR--se.......................................
H9ZZA3_FERFK/2-297                  ........................................................m-QMLFSLV..KDV.pKRLYWLRSNDPVPEDLRGWSYHTYPVRPRAY.FGLGVSEVAYKYCETFRDLWMR.RKEYVRGEvlES.S.PLY....MGKLIHSLMNYAFRDASEIVSR.N.L.G.PL....---....E.....S........IR...R...A..QELS...........rKRASELTK................sYYRKAMEFY..MT..MVL..SAISTLW...IQ-....QSLTND...P..LSY--......IS..I.K.TEFVID.GTPVGLSNTLRVDA-YHEGG.......V.I.I..EYK.L......GNpd.plLTE.....R.....HSVGLAGYALAIESSL.DIPIDYGAIVYI.sEL.SRRP...SIKVFPV....YISSLYR.KKFLENRDEAIEVLMRATP...P.P..RS.G...NCY.QY..CPFFKACNG-ge.......................................
K8DY73_9FIRM/1-303                  ...............................................myflsdeekk--------..HLL..KGYLPRSRQTYIVDELRGWNWHQPPLLPPYE.LKLGAYEIANAYCPSYRDLYLR.RVQKVRSQ..PN.L.AML....RGAFLHDILVKEIIAAKKIIYK.T.G.I.AS....YKT....I....fK........QL...E...K..REPY............KVPDNFQLndkek.......aclerEAEIIVKFE..RQ..RLT..SRIHDVL...VKQ....PYIGED...S..LVNIA......VP..L.V.VEQKLD.GSFLGMSAHLSIDAYTFSEP.......M.I.L..DLK.F......GE.....KKS.....F.....HRLQTTAYALAMEAIY.EFPVNLGCIVYA..KI.KDDR..lFIEKDIH....IIDEELR.QWFIEERDEKMRLVEEEID...P.G..V-.K...DCL.DT..CPYYQFCH--.........................................
A0A6N7IM04_9FIRM/1-309              ......................................................myf--FTDEEK..KNL.yRGLLPKAREMGVADELRGWNWPFPPLAPIYD.VLLAIYEVAGAYCPTGRDLYLR.RVKGIKTR..PN.L.AMQ....KGTVLHGALAHLIVAAKRIIYE.E.G.V.AN....YQK....I.....V........AR...L...-..NELP............LYPPECWPgeadpgedpenyarllrNVKVLTDFE..KS..RLI..ARIQEIL...VKQ....PYIGED...S..LVSLA......IP..V.V.VEQKLD.GSFLGLSPNLSTDAVTYPEP.......V.I.V..DLK.F......GR.....PQP.....F.....HRLNTTGYALVMESLY.EFPVNLGCLVYA..EF.KDDR..lLVRKDLH....IISDELR.QRFCEVRDEKARLVAEEID...P.G..VP.E...NCP.AS..CPYFPFCR--.........................................
Q8ZZL7_PYRAE/1-280                  .........................................................MLTLQEIA..RLL..RRAKITWGPVEISPEYRGWNYDKPPVKPPAY.LGLALSDFAYGYCPTGRNIYLK.YVLGERGA..AV.K.ALV....EGQALHQALFKALEDYKKYAYS.G.H.P.MS....PSF....E.....-........--...-...-..----............GVPEDVRP.................KAEALYKYV..AT..RLL..GEHSYVS...AAR....LARSRD...S..AVFYT......AP..I.A.TQVAVD.GSPLGMS-YVVADG--VALG.......A.V.I..EFK.F......GP.....AQN.....V.....-DAALAGYAMAIEADW.GVPIDYGIHVQI..TV.NSTV...EYKATAY....PLGDSAR.TKFLELRDEAIDIVIAGRD...P.G..VA.P...DCP.KT..CPFYHICHA-dr.......................................
A8ABK7_IGNH4/16-109                 .......................................lprwvwdelratagetvv--------..---..--------------HTRGWDWQL--LQPRYK.ARPSVSDLT-SPCPTKRDVYLR.KVLGVRLE..-S.E.AMS....KGRAVHEAFMAPFKGV------.-.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------...---....------...-..-----......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-.....----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------eletedpllkr..............................
A0A0M2U345_9FIRM/1-306              ................................................myfltdeek-------K..QLL..RGYLPKSRELGVNEELRGWNWHRPPLSPIYD.LKLALYEVANSYCPSNRDLYLR.RVDGLKPA..PN.V.AMI....RGKAFHETLVQVLVRAKRTIYE.K.G.V.TN....YQD....I.....I........RA...L...S..EPFQpdlr...pyrnqL-----TKsdfe.........dlqkKAITIAAFE..SS..RII..ARIQEIL...VKQ....PYIGED...S..LVSLA......IP..V.V.AEQKLD.GSFLGLSANLSADAFTFSEP.......M.I.L..DLK.F......GE.....PKK.....F.....HRLTTTGYALVMEAVY.EFPVNLGCIVYA..DF.KDDR..lLIKKDIH....IIDDELR.QWFIEERDEKMRMVYEEID...P.S..LA.E...KCY.DT..CPCYSACHG-.........................................
H2C4W1_9CREN/12-295                 .........................................................MLSQAEMF..RSL..RKLHSWRSSDPVPEELRGWSYHRPPVRPRSY.LGLSMHEVAYLYCPTKRDVYLR.RIMKVKGD..WD.KpHIQ....LGSLVHKVVGRASRDVALVALS.G.Q.D.PV....EAF....S.....S........FN...P...-..---S............LECGEMEE.................YCRKLYKFL..TL..TWL..ADTARSR...AV-....----YG...G..EALGL......FP..W.V.SEIRVD.GSLLGLSNKLSIDA--LGSL.......A.L.V..EVK.T......GK.....RED.....F.....HKVGLTGYALAVESSL.EVPVDFGFLVYFngVG.KGEV...EVQVDPV....YVSPDLR.KEFLDRRDEVVDIVVSQRD...P.G..MP.P...TCP.EA..CPFYSTCNG-r........................................
A0A2U9IJ08_9CREN/1-284              .........................................................MLTRLDMI..RGL..KSLHEIRATDPVQEELRGWYYYSPPVKPRAY.LSLSISDVAYAYCPTKRDVYLR.KVTGSKGN..YE.KpQII....NGTAIHKVFYKASKDVWSIISL.G.K.D.PI....ESF....N.....S........LA...P...-..--EL............ECPQNLQN.................YCIKLYKYL..TM..LWL..SEVAKAR...SS-....--YGGE...S..IGL--......VP..W.L.SEVRVD.GSMLGLSNRLSIDA--IADF.......S.I.I..EIK.T......GK.....QED.....F.....HKLGVVGYALAIESSM.EIPIDYGFLIYV.nGF.NRDS..iEISTNAI....YISSDLR.KEFLDRRDDVIDMILSEKD...P.G..MP.A...SCP.DS..CPFIEVCR--k........................................
A3DLB8_STAMF/1-310                  .................................................myyldeie-------Y..KLL.iHDLLPRTRENPIDDRLRGWNWHQPPVRPYSFeLQLPIWEIAGSICPTYRDVWIRrKVLRKKLF..TT.S.KQA....EGVIIHKIVSHVFKEAKKLIYS.G.D.Y.SD....LKN....AllpgvK........EL...V...D..NEVKy.........isE----LVEnida........nkikeFALQVADWE..ML..RIE..GRINTVK...AKY....PYIDEE...G..LVSLA......VP..V.S.LEMPVD.GRLLGLSSMLRVDASWLPGG.......L.I.Y..EIK.T......GY.....REK.....W.....HKLQVAGYALALESIY.ERPVDIGVVVYV.nRA.VEGI...RVNRDIF....VVSDDLR.SRFLEKRDEIQMLLLKGEE...P.R..IP.D...KCP.RK..CLFRNICL--ge.......................................
E1QU80_VULDI/3-265                  ..........................................lprwvwdyikvtmeg--------..---..----------GSYAEIRGWFRDA--VAPRHV.VRPTVSEVS-SPCPTKRDAYLR.RVAGVTME..DS.E.SLR....LGRMVHEVFLTPFKESIPF---.-.S.Q.LD....NRF....E.....S........II...N...-..----............--------.................----EYGDL..GN..KYR..AQLYEVY...TK-....AVATSL...N..AREEG......IP..I.S.VEPAIP.GAPIGLSDIVKPDILVGFIPv.....eL.V.T..SSQpT......EE.....LTS.....R.....KDIAVTAYALAIEAWI.GHPVDIGVVLHI..SI.NGKP...RLTWRVV....KIDDTLR.RAFLDMRDNVARIIEHGDD...P.G..PA.S...SCP.RT..CPFYGVCHG-.........................................
G0EGJ8_PYRF1/4-289                  ....................................................llaas-----SLA..RAL..RKLHLLRAADPVEERYRGWSWHSSPVKPRYF.VGLGVSEVAYRYCPTRRDLWLR.RVRGLRGQ..PT.E.AML....KGRIVHEAFRLAARDLSRLVLG.E.G.K.ST....EDA....V.....-........--...-...-..---A............ELVGGARE.................RASVILESA..GI..EGD..GDGIAVF...AAR....VYKKMV...F..AWAQWmeetgaPP..W.I.TEYEVD.GGLLGLSRRLRVDA--LAPG.......L.V.V..EVK.Y......GR.....WSR.....D.....YPVALAGYAMALEASL.EIPFDYGLVILV..NG.-DGS...RLTLEPV....YIGNEER.AEFLTARDEAAEIVVSQVD...P.G..RP.P...RCP.DQ..CPMRLVC---ap.......................................
A0A023X6Y1_9ACTN/1-284              ...................................................mfmpta----EEKK..RLL..RGTIPRARRLGVDDSLRGWMWSAPPLLSPYE.VPLGLAETANAYCPTARDVYAR.RVLGASPE..PN.G.KMI....LGKDLHDTLGAWIVHAKKSLYT.H.G.A.ND....LEA....A.....-........--...-...I..ESIR............TFPEPDLP.................EQKTLVLYE..AD..AVE..FRLREAV...SQF....PRIRTD...A..LVAHV......LP..V.T.LGQMLD.GAFLGLSRRLSTDLLNLGEP.......C.I.L..NII.F......GD.....EKR....pF.....HALTLAGYALVLEAVH.EFPVDVGVTVYV..DF.DGGR..pRIERDFT....VLGDEVR.MEFIEVRDEKQRMVADQSD...P.G..PC.E...GCE.AW..C---------s........................................
A0A031LIY4_9CREN/1-295              ...................................................miiyak--------..---..-RAKNT--PRAISEELRGWKWSDPPVLPPSS.SFIGVSDITGGLCPNGRIIYLR.YVEGVREP..SS.P.ELG....RGSIIHSAYSKGIENVKKLILD.G.E.T.RG....-DR....I.....R........TA...M...A..DDLP............ILLKEISRfsnv........pnyqeVAKLIWNHV..SD..VYS..VEVDKVR...GKS....PFLSRD...S..LVSLV......VP..F.Y.VEFPID.GSLLGLSSNLRADAFIPQIP.......I.I.A..EMK.T......RK.....PKE.....V.....YSLTLAGYALAYESVY.EVPIDFGLLCYV..RV.DEQSsivQPKCDFK....VINDRLR.QDFLEERDRRLEIKERGVD...P.G..LP.K...YCE.AD..CPFLTTCGG-r........................................
L0K8Q1_HALHC/1-305                  ...................................................myflts-----EER..QKL.vRGLLPKARQMEISDELRGWNWNQPPLEAMYE.EKLALYEIAGKYCPTGRDLYLR.KVEGVKTE..WN.Q.AMI....QGKVLHDTLAELLVKAKKLMYC.H.G.I.EG....QKI....I....iE........KL...Q...E..VSFV............ALEKWESKldqef......ylelkeKIKLMWQFE..YN..QLV..VRMQGLL...AKQ....PYIGVD...S..LVNLT......IP..I.V.VEQKLD.GSFLGLSSYLSADAFNYCEP.......M.I.L..DLK.F......GK.....PKD.....F.....HKLTITGYALVMESIY.SYPVSVGCLVYP..EF.RGDR..iVVKKEFE....IIDDELR.QWFIEERDEKMRMVCEEID...P.E..VA.Q...NCY.QT..CPYYEQC---y........................................
F4B6T2_ACIHW/1-283                  ...................................................mynvrs-----QII..RQV..RRLHSYRASDPIEEELRGWNYHMPPIKPRRY.LGLSMSDVAYRYCDTKRDVYLR.RVLKVQGE..QR.S.ALV....LGQSVHEVIASVSNEIVKLLSL.G.Y.K.PW....AAI....E.....A........IF...R..kA..NKVS...........nLCPQQFFK.................FCEEVYKAF..AL..DLI..SDFSD--...---....------...S..TSF--......LP..I.I.SEFRVD.GTPLGLSSKLSVDA-ITQLS.......L.V.V..EIK.V......AS.....TQE.....F.....HKLALAGYALALESAL.ELPIDFGSLIYV.nGI.NKNT..pEFKYEVY....YISPDLR.KEFIDARDEVIDMVSEGRD...P.G..MP.T...ACC.PS..CPFLNYCN--kg.......................................
B0TFX6_HELMI/1-310                  ...............................................myflsdeerk--------..KLL..HYYLPKARREGVAEELRGWNWSQPPLSPVYD.CPLGVFEVASGYCSSSRDVYLR.RVEGARSK..PN.G.AMF....QGSLLHGLAARFIVATKGLIYQ.E.G.V.DG....YRE...iL.....R........KL...Q...E..MTLSelldeglvfelaSLA----Eadre.........elerKSRLLLEFE..RG..RLI..ARLQEAL...VKQ....PYIGED...A..LTALA......VP..V.V.VEQKLD.GSFLGLSAHLSADAYNIGQP.......M.I.V..EVK.F......GE.....PRD.....F.....HRLATAGYALVMEAVY.EHPVDVGCLVCV..TF.KGDR..vIIRRDIH....LIDDELR.QWFVEARDEKARMVYEEID...P.G..LA.K...DCP.QS..CPFANRC---s........................................
F4B5P8_ACIHW/1-293                  .........................................................MFFTSSDI..LLL.sRRIKKS--PRAIDEELRGWNWNEPPIYSQHF.SQTSVSELI--YCSTLRNLYLR.QKGYKVGE..ES.S.LIK....KGRAIHDTYSTAISTIKRLLYS.S.P.Q.ID....GNK....L.....K........TL...M...T..DEFYs.........flKKYEDQAD.................YVKTLWDYI..TN..IYS..AELDRVR...SKF....FNLTED...S..LVSSV......VP..F.Y.VEYPVD.GSLVGLSSSLRIDAFVPFIP.......L.I.A..EMK.T......GK.....YKY.....S.....HELQLAGYALAFESQY.EIPIDFGYLCYV..NVdEKEV...KSNCKLI....QISNSLR.SEFLDKRDKALEIMDNVID...P.G..IA.N...DCE.KE..CPYYKVCH--ps.......................................
A0A2H5V0A7_9ARCH/6-307              ..................................................mvyflga--------..EEM..REVEREASKTVIDESLRGWSYNSSPVRPPYD.IPLPVSVIANRYCRCGRDVYLS.YVLRQAGK..PP.T.EAR....TGHLYHEIISSIVEEAKRFIYN.Y.G.TaPP....IEL....Y.....Q........YLd.tM...G..ETTI............QGLADKLKlpted.......slhvrNARKLWMYM..SL..EIS..HSLNTVL...SRG....VGVSLD...T..LVSAT......IP..F.V.VNYLVN.GRPVGLSERLQADA-LGAMS.......L.V.L..DLK.T......GP.....PMD.....F.....HKLTTTGYALALESSL.SQPVNVGCIVYL..SF.RDESptpIVIRRIH....AIDESLR.MEFLEERDRKQRIVAEGID...P.A..KP.S...ICD.PN..CMYLN-----l........................................
D5U1T3_THEAM/41-321                 ....................................................lilrr-----VMF..RSI..RRLYELARADPVDPELRGWSWDRLPLKPRAY.LNLGVSEIASKYCETRRDIWLR.RKTGARAE..PT.E.PIL....TGRLIHDAISLALKETAKLLIN.N.T.E.PY....TAY....Q.....I........LS...-...-..EKWRk..........lNPPKGYEK.................TVEKTYKAT..LI..TIL..GEAMY--...EK-....--L---...-..VNETP......QP..VaY.SEYRVD.GTPLGMSQNLSVDV--ISDS.......V.I.I..DFK.T......GA.....PRD.....F.....HKLSITGYALALEAAY.ETPRDYGLLIYI..NN.PEDP...RITYKPV....YISNTLR.RLFIEERDNIIDMLLEDAE...P.P..KD.L...NCQ.PT..CPLHGACN--k........................................
A0A7G6E237_9FIRM/1-306              ................................................myfltdeer-------K..QLL..KSYLPKSRQMDIADELRGWNWNQPPLEPVYD.IKLALYEIANSYCPTNRDLFLR.RIDGVKAR..PN.A.AML....RGKLLHQVLVDVLVRAKKLIYL.H.G.V.GN....YQEflqeH.....K........IP...F...K..TNFE............RYRSQLSEeefs.........slarDAEILANFE..TS..RIV..ARIQEIL...IKQ....PYIAED...S..LVSLA......IP..V.V.VEQKLD.GSFLGLSQNLSADAFTFSEP.......M.I.I..DLK.F......GE.....PKK.....F.....HRLTTTGYALVMEAIH.EFPVNLGCLVYA..EF.KNGR..lSVKKDIH....IIDDELR.QWFIEERDEKMRMIYEEID...P.G..IA.Q...NCY.DT..CPYYRNC---lg.......................................
A0A830GW72_9CREN/1-304              .........................................................MFYTLDDS..IRL..SRQFGKRPREFVSDELRGWRWNEPPLLSDSP.TRLSVSDVASGICPTGRDVFNK.SVSHVRPG..DN.P.SMH....LGLLVHITYETAVRTAKKLIYS.G.I.N.KS....SDF....I.....D........AM...R...N..EGERn..........iALTRRLRRwsiae.......ddfqsIYWSLWDQA..TS..TYS..GALGKAR...TLS....KYATLE...S..LAGAV......IP..I.N.VEFMID.GSLIGLTKAIRIDG--VLLP.......F.IpI..ELK.T......GP.....PSE.....W.....HRVALAGYALAMESQW.ETPVDFGVLIYV..DF.QDGD..lYIREEEV....AIGDELR.MDFIHERDRRASIAEKGVD...P.G..MP.D...KCN.TW..CPYLEYCG--qq.......................................
Q9YCL7_AERPE/84-260                 ....................................................ahrvg--------..---..-------------------------------.----------------------.--------..--.-.---....----------------------.-.-.-.--....---....-.....-........--...-...-..----............--------.................DAYRMFNYL..LR..RVR..ARGNEIRvmnAVF....EKAVEF...S..AAARVd....gIP..V.A.VEPNVP.GGPVGLSDYVRPDLLVGIMPv.....dL.V.L..AGH.G......DR.....WVA.....R.....KELAIAGYALAVEAWT.GNPVDYGVVVGL..RV.NDGL...KIVWRLV....RVDDHLR.TRFLERRDAVARIIEYRSD...P.G..LP.E...ACP.PG..CVFREVCG--v........................................
Q9YCL7_AERPE/1-90                   ......................................................mfp--------..RGL..WDLVRSSAGDGVYAELRGWKWNV--VGPRYA.ARPTLSDVT-GVCPVGRDTYLR.RVLNTRVN..-G.G.LLR....LGALVHEAFLLPFKAHRV----.-.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------...---....------...-..-----......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-.....----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------gda......................................
A0A348B575_9CREN/1-300              .........................................................MFFTPEDV..ALY.aKRVRQT--PRQVGEEMRGWRWPEPPLLPPSG.RTLPVSDASGALCQTGRYVYLS.YVKWVKAP..TS.P.EAA....RGSLIHEAYAESVETVRKLIYS.G.E.V.VD....GNA....L.....R........SA...M...L..DEYY............EAERRLSEyssv........qdfhnVVKAIWDRA..TS..VFG..ASLDRAR...ER-....ARGRRE...T..LAAAT......IP..F.L.VEFPID.GSLVGLSPNSRVDALIPNVP.......L.V.V..EMK.T......GA.....RRR.....A.....HERALAGYALAYESQY.EVPVDFGLLCYV..RV.EDKV...SDRCELL....KIGEALR.TEFLEERDRRLQVLEDGVD...P.G..LP.K...FCD.RE..CPFLSHCGG-kv.......................................
E0STX3_IGNAA/124-297                ................................diewlygmfrrslkdyadlrgywka--------..---..-------------------------------.----------------------.--------..--.-.---....----------------------.-.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-----FE...SVF....RKSLAL...S..MIAEEe....qMP..I.S.VEPYIP.GGAIGLSDFVRPDLMVGFMP.......I.D.I..TLS.L.....gGN.....SLE.....R.....KELALAGYALAIEAWS.GNPVDIGITIGI..SI.NSDV...RFQWRVV....RIDDSLR.RRFIEARDDVARIIEYGED...P.G..KP.S...QCL.KM..CPFREVCG--v........................................
C9R974_AMMDK/1-307                  .....................................................myff---TDEEK..KHL.lRYHLPRAREQGVAEELRGWNWHQPPLEPVYRdVVLALYEVANSYCPTGRDVYLR.RVQQKRGR..PN.L.AMI....QGIIFHAVVADVIVAAKRAIYS.E.G.V.AN....YRAi..vE.....R........IQ...N...H..PPIPl..........dEWAEQLSKdqld.........dtlaKAEILATFE..KT..RVL..ARLQEIL...TKQ....PYIGED...S..LVSLA......LP..I.V.VEQKLD.GSFLGLSPNLSTDAFVFWEP.......M.V.I..DIK.F......DR.....QRD.....F.....HRLTTTGYALVMEALY.EFPVNLGCIVYG..EF.RGDR..lIVKKDIH....IISDELR.QWFIEARDEKARLVAEEID...P.G..K-.G...ECY.EE..CPYFHICW--ge.......................................
A4YFV5_METS5/1-272                  ......................................................mrs-----QIT..RQL..RLLHSYRASDPIEEELRGWSYHHPPIKPRRY.LSLSMGDVAYRYCETKRDVYLR.-RNGVQGE..AN.Q.ALN....HGLSVHRIFSTISREVSRLTLS.G.L.P.PW....DVV....S.....-........IL...M...-..SRCSk..........lSRECQDRS.................GCEQACKSF..SL..DLI..SDYFD--...---....------...S..TSF--......IP..T.I.SEFRVD.GTPLGLSPRLSVDA-ITQFS.......M.V.V..EIK.T......GT.....PQD.....F.....HKLALAGYALALESSL.ELPLDFGTLIYV..R-.--GG...ELRYESH....YVSPDLR.KEFLDSRDEVISMLSEDRD...P.G..LP.T...VCY.PS..CPFLSHCRG-g........................................
S5Z705_9CREN/14-115                 .................................................yfskrdly--------..ASL..RRFHRARSQDPVEEEYRGWNWDKPPLRPRAY.LGLGVSEVAYRYCPTMRDVYLR.-RMGVEGE..KN.Q.WLA....NGELVHRVFQMVSEEVRREL--.-.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------...---....------...-..-----......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-.....----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------algrs....................................
K4LGE4_THEPS/1-307                  ..............................................mmyflsdderk--------..QLL..RYYLPKARELGVVDELRGWNWHQPPLEPVYG.SVLALYEVAGKYCPSGRDVFLR.RVQGIKGE..PN.S.AMI....QGMVLHEVLADLLVTAKRAIYL.H.G.T.EK....YRAiceeL.....E........KYipeK...T..SHFAgl........tdSEAADLSR.................KVEILCSFE..KA..RVL..SRLQEVL...TRY....PYIGED...S..LANLT......IP..V.V.VEQKLN.GAFLGLSGNLSTDAFIFYEP.......M.I.L..DLK.F......GE.....PRD.....F.....HRLGTTGYALVMEAIY.EFPVNLGCIIYG..EF.RGDR..lIVKRDIH....IISDELR.QWFIEERDEKARFVTEEID...P.G..LA.E...DCP.AT..CPFYHVCC--ae.......................................
CSA1_SACS2/1-291                    .........................................................MFFTHSDM..LLL.sKRIKKL--PKNVDEELRGWNWSEPPVYTRSL.SQVSISEMV--YCSTLRNVYLK.-VKGFRGE..IG.R.QIL....QGSLIHTIYAIGIEAIKRFIYS.R.E.S.ID....GST....L.....R........TL...M...G..DEFY............SLLKDLREee.............giYAKVLWDHI..TN..IYS..AELDRVR...SKF....TNLTRD...S..LVSQV......VP..F.Y.VEFPVD.GSLLGLT-NLRVDAFIPHLP.......L.I.A..EMK.T......GK.....YRY.....T.....HELSLAGYALAIESQY.EIPIDFGYLCYV.tVT.EKEV...KNNCKLI....PISDSLR.SEFLDMRDKAQDIMDKGVD...P.G..IA.K...DCE.SD..CMFYKVCH--p........................................
A0A4R8HFU4_9FIRM/1-305              .......................................................my--FLTEEE..RQLlvRGLLPKSRRIGITDELRGWNWNQPPLEPMYD.HRLALYEIAGKYCLTGRDLYLR.KIVGVKSK..WN.Q.AML....QGSILHDTLAELLVTAKRLIYS.Y.G.V.NK....QSL...iI.....E........EL...Q...K..PNFKhldkk.kgildeEFYSELRD.................KVGVIWQFE..YN..RLI..FRMQELL...AKQ....PYIGVD...S..LANLT......IP..V.V.VEQKLD.GSFLGLSSHLSADAFNFCEP.......M.I.L..DLK.F......GK.....PRD.....F.....HKLTITGYAMVMESIY.SFPVSVGCLVYP..EF.KNGR..lLIKKEFC....IIDEELR.QWFIEERDEKMRIVSEEID...P.G..VA.N...KCY.QS..CPYFEECH--.........................................
O28400_ARCFU/1-281                  .........................................................MVYFLNELehKFL.tLELRPRIRQNPVPEELRGWNWHSPPLKPYYN.VKLPMYLICSRYCPTSRDVYLT.MVEKVRGE..ES.F.PVS....LGKAIHEAVAKAIREAKSKNFS.A.E.P.PN....YDN....E.....M........IN...V...-..----............--------.................AVKAVWEYT..MS..LCQ..SSYLKVR...SEQ....PYATEE...G..VLLTS......MP..F.L.VEHRMD.GSLLGCSGLISVDCYDYLRN.......V.V.F..DLK.V......GE.....FNE.....E.....MRLYTTGYALVLESIH.EIPVDVGCIISI..TF.NGER..mRVSKDLH....YIDANLR.SWWIEERDRKAEIVFNEAD...P.G..VA.K...SCS.SN..CLFNAFC---l........................................
A0A2V3JM66_9EURY/2-257              .....................................................sdtv--------..---..-------------------------------.---LVSDIV-TYLRCPRLVYFA.NLLNNREP..VE.R.DVN....ARYLAHLLSKELALTYHRAAAS.T.S.E.DV....AEV....L.....Q........TE...L...-..DRIV...........nELPMIYRAel.............agVDHSVIRDA..AE..SIDtgAIGLQII...DVI....RKTGRD...E..LLARI......TP..C.A.VEYAIY.SDALGLA--GSPDKLVRVGD.......C.V.LpyMIR.T......GNtpengVWK.....P.....DRMQITAYAMLVEERF.EQVVEYGFVEYA..RF.----...-FEIRKV....VIRSGDR.RRVLELRNRV-RMIKGGRM...P.D..RA.Q...GAPcEL..CVFEEDCV--ak.......................................
A0A7L9FLB2_9CREN/3-261              .....................................................papv--------..--L..ERVRGVVAGDLV-VELRGWRLEL--VGPRRG.FMPTVSEVS-SPCPSKRDVYLR.RVRGLKPA..SD.G.VLL....AGRVFHEAFLEPFRVVLRAGPS.L.E.R.LA....GAK....A.....R........LL...R...-..----............GAPRELRS.................AASRVFDAS..SA..LAM..A------...---....-----W...G..VGGAR......LP..V.A.VEPEVP.GGPVGLSDVVRPDL--LVAG.......V.P.V..DFV.Y......GN.....GLE.....R.....KELAVAAYAMAVEAAS.NNPVNYGVVVQY..--.-AGG...RLLWRAV....ILDDRVR.SRFLEARDAVARIVESGED...P.G..VA.E...SCP.DW..CPWRGVCHA-al.......................................
B8D4S8_DESA1/1-280                  ........................................................m-------L..RLV..RRIYSWSRADPVDEELRGWNWDKPPLKPRAY.LDLGVWEVSSKYCGTRRDLWLR.RKMGVVVE..PS.E.SMA....KGKMVHEAITTALREAGRYLSN.G.L.E.VW....SAY....E.....A........AK...-...-..EKWRri........dtGGSRENAR.................LVEKIYKST..LL..SIL..GEAAYE-...---....----EA...L..YGSRR......PP..LaI.SEYRVD.GSNLGLAPNLSADL-VAEGG.......V.I.L..DIK.Y......GA.....PRE.....F.....HKLSLTGYALALESEY.EVPYDYGILIYI.qGY.LESL...KINIKPI....YINSYLR.RYFIEERDEIIDMLIENRE...P.P..RD.S...ACN.PS..CPFYKVCN--k........................................
I3TFC8_THEC1/4-283                  ...................................................lfarrl------VL..RSV..RRLYAWSRADPVEEELRGWSWDRPPVKPRAY.LGLGVSEVAGKYCPTRRDVWLR.RKMGLAPE..TT.E.PLA....KGRLVHEAVTAAVRCASRGLSR.G.W.E.TW....DIL....T.....-........-Y...C...L..GRFR............PQGNGDTA.................TALKAYKST..LV..TLL..GEVEYE-...---....-RLVSG...G..---SG......LP..V.V.SEMKVD.GTPLGLSPQLSIDV--YAEN.......I.V.V..DFK.T......GA.....PRD.....F.....HKLSIAGYALALEAEY.EVPVDYGILVYV.nPS.DSGL...RVLYRPV....YVSNELR.RWFLEERDEIVDMLVSNRE...P.P..KD.K...NCP.QT..CPFYRVCH--q........................................
A8ABK7_IGNH4/106-249                ................................................llkrvyeea--------..---..-------------------------------.----------------------.--------..--.-.---....----------------------.-.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------...---....-KVRKA...A..AEEEG......IP..V.E.VEPEIP.GHSVGLSSALKPDFLVGFIP.......-.-.V..EVV.Y......GN.....GLE.....R.....KKLAVTGYALALESWI.GHPVEVGIVVSV..T-.--DK...KTYWNVV....RIHEGLR.RRFLEVRDEVARILGEKED...P.G..AP.E...ECP.KA..CPFAEVCK--r........................................
A0A5Q2N509_9FIRM/1-307              .................................................mifftdee------RR..RVL.fQELQRL-KEQAVDEELYGWNCFRKPLCPFYN.TFSVESETLTERHESYEQVSST.GNSSAWEE..MT.V.TINpvgiAEKVYYDVVVNFLSAVKLLIYQ.Q.P.G.KA....PVD....V.....L........NE...I...Q..KEIEklq......vlgLLSKDVLDllpiypk..eqdqrvlaNAERLLNYE..RR..RIM..VRIEEVL...AHH....RNISMD...F..LALKT......VP..L.N.LQMSLQ.GHLIGLVAGLKADVI-RITElg...ssA.V.V..ILK.VlknhrdDR.....FDEapisfS.....HRMLTTAFALALESNF.YNPVHVGVIVYL.sFV.GQDI...FVDKDIH....LIDNDLR.ELFIEWRDG----------...-.-..--.-...---.--..----------swn......................................
A0A2H5UZ86_9ARCH/2-69               ......................................................myy--------..---..-------------------------------.----------------------.--------..--.-.---....----------------------.-.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------...---....------...-..---HS......FP..F.V.VNYLVN.GRVVGLSERNQADE-LGAVS.......L.V.L..IFK.R......GP.....PMD.....F.....YKLATTGYALALESSL.FQPV--------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------l........................................
A0A510DYE0_9CREN/1-287              .........................................................MFFTLSDV..MLL.sRRTRST--PRSISEELRGWNWSEPPVYPPST.MTLGVSDLTNGLCPTGRFAFLK.-YTGKKVE..-V.K.PL-....PGASVHEVYAKGIETVKRLIYE.-.E.D.LN....GAR....L.....R........TL...M...E..DEFY............SLKVEDLT.................LAKAIWDRV..VN..TYS..AELDKAK...GRS....PYFSRD...S..LASMV......VP..F.S.VEFPLD.GTLVGLHNGVRADAFIPHVP.......M.I.A..EMK.T......GK.....PRR.....Q.....HELALTGYALAYESMF.EYPMDFGYLCYV..QV.KEGR..vFDSCRLV....QVGDYLR.DEFLQMRDKVMESIENGVE...P.E..KP.K...RCD.QD..CPFLKVCN--p........................................
Q97Y83_SACS2/1-281                  ......................................................mrs-----QIV..RQL..RRLHSYRASDPIEEELRGWNYYMPPIKPRRY.LGLSISDVAYKYCETKRDVYLR.KVLKIQGE..QR.T.PLL....LGQAIHEIVRNVSNEVVKLLSS.G.Y.K.PW....SVL....E.....T........LF...R...N..NKIVr..........sLCPPQFIK.................YCEEVYKAY..AL..DLL..SDFSD--...---....------...S..TSF--......IP..V.I.SEFKVD.GSPLGLSSRLSVDA-IMQLS.......L.V.V..EMK.V......GS.....VQE.....F.....HRLALAGYGMALESAL.ELPIDFGALIYV.nGI.NTSS..pEFKVEVF....YVSPDMR.KEFLDARDEVIDMISQEKD...P.G..MP.V...SCS.PS..CPFLNYCNN-nk.......................................
A0A0U2U6Q3_9CREN/92-237             ..............................................llkkvheeakl--------..---..-------------------------------.----------------------.--------..--.-.---....----------------------.-.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------...---....---RKA...I..ADEEG......IP..Y.K.VESKLP.GSVIGLSTIVKPDFLVGFMP.......V.E.L..VYG.W......NG.....NVE.....R.....KKLALAAYALVIEAWT.GLPIDAGVVINV..N-.-D-Q...GIKYVLV....RIGDYYR.RKFLEERDYLASILSRKED...P.G..RA.E...SCP.NY..CPFAEVCK--q........................................
Q977B6_SULTO/1-288                  .........................................................MFFTLSEI..QLL.sKRMKGF--PRAISEELRGWHWNEPPLYPSSN.TLLSVSDLTNGLCDSGRYVYLK.-HKGIVPK..VE.A.KI-....-GNTIHTTYATAIETIKRLIYE.H.E.D.LD....SVK....L.....R........TL...M...T..DEFY............NLKVEVIE.................VAKILWDHI..VS..IYS..AELEKAR...SK-....PFLRKD...S..LASLV......IP..F.H.VEYPVD.GSLVGLQSALRVDAFIPILP.......L.I.A..EMK.T......GS.....YKR.....D.....HELALAGYALAFESQY.EIPVDFGYLCYV.nVI.EGKI...HNNCRLI....VISDTLR.QEFVEVRDRALRAIDDDVD...P.G..LA.K...KCS.AD..CPFLPHCKG-g........................................
S5ZDL3_9CREN/1-117                  ........................................................m--------..---..-------------------------------.----------------------.--------..--.-.---....----------------------.-.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------...---....------...-..-----......--..-.-.------.---LGLSRNLRVDA-LVETG.......V.V.I..EVK.L......GK.....PHE.....N.....YKRALAGYALALEANY.EVPVDYGILLYV.sIA.NGGK..vGFSWEPV....YISTSLR.SEFIDARDEVIDMLVSGKE...P.P..RA.E...VCP.ES..CPFRGVC---g........................................
A0A4R2RGP8_9FIRM/1-312              ..................................................myfwtse-----EQK..RLL..RYFLPRARREGVAEELRGWNWNQPPLSPIYE.CSLAVYEVANGYCDSARDLYWR.RVERVKAA..PN.K.AMV....QGRLFHALVAGMMVETKRRIYK.Y.GvD.AY....PEI....L.....R........EI...N...E..LGLN............ELLDEKTKqagktlde.etraqvldKMKLLLAFE..RG..RIV..ARMQEVL...VKQ....PYIGVD...S..LAALT......VP..V.V.VEHKLD.GSFLGLSAHLSTDAYQMGES.......M.I.V..DLK.F......GE.....PRP.....F.....HRLATTGYALAMEAMY.EFPVNVGCVVYV..SF.AGDR..vRVQRDIH....LINDELR.QWFIEARDTKARLVAEELD...P.G..MA.K...ECQ.KD..CPYAGRCKG-g........................................
E0SSI5_IGNAA/1-240                  ........................................................m--------..---..-----YRASDPVDEGLRGWHWYEKPLRPRAF.LELSMADAVYRFCPSRRDLWLR.RRIGVEGE..AS.D.GMR....KGFAIHSIFHISSGVVAKAIFS.G.Y.S.PW....DAY....E.....Y........GY...R...-..----............----QCIK.................SAK-VYNNI..INveKLC..KEFSFIW...SS-....------...M..AMELG......SP..IaI.TEFTVD.GSLIGLSRNLRVDA-LFEGS.......V.I.I..ELK.Y......GS.....FRR.....D.....YIDVLAGYAIAMESFI.EMPIDFGILMLV..NS.DG-T...AIKIEPV....YIGNDVR.KEFIELRDEAIDILLS---...-.-..--.-...---.--..----------dv.......................................
A0A2H5V4I6_9ARCH/1-313              ..................................................mfflrre-------EfeRRL..RALRDQVDAAMVSPELRGWNSSRPPVKPLGR.HLLSVSELASRYCPTMRDVYLR.RIARISPP..PS.F.KMF....RGLVYHFIINQLTTRSKRYIFE.R.G.KiPG....PEL....F.....K........LL...L...I..DEPV............AVESAVRDastkvqvdedevrsltlLASRLYRYL..AL..QVA..SGVDLTQ...SKF....PHVDVD...S..LVNES......IP..A.V.SEMKVD.GSLVGLSRELSVDIYT-PYN.......T.V.I..DIK.T......GD.....IRS.....F.....HRYVGAGYALAIESDK.GVEVDFGVTIYI..SV.QPSApapEVKADYY....LIGDELR.REFLELRDEAQLLIEKGKD...P.G..MP.V...KCP.EF..CPYYTVCN--r........................................
CSA1_THETK/1-278                    .........................................................MLTLLEIA..RLL..RRAKVTQGPAEVSPELRGWAYDRQPVKPPAY.LGLALSDFAYGYCPTGRSLYLK.YVLGERPQ..PT.K.PLA....EGQALHAVLFKALEDFRRYVYS.G.A.P.MS....PPG....E.....-........--...-...-..----............GMPEDLRA.................KAEALYRYI..AV..RLT..GEYQYVL...ASR....LARSRD...A..AAFYA......AP..I.A.AQIAVD.GAPLGLS-YVVADG--VALG.......A.V.V..EFK.F......GP.....SQN.....V.....-DVALAGYAMAIEAEY.GVPIDYGIHVQI..AV.DGQV...EYRASAY....VLGDAPR.AKFLEARDEAIDVVASARD...P.G..PA.P...QCP.KT..CPYYSVCR--s........................................
K0ICJ6_NITGG/1-318                  ................................................myflsgedr--------..RRL.fKGIVSRGRTMTVDESLRGWNWDKPPIEPPYDtIKLGVYEVASQYCQSGRDVFVR.RIDGIKGV..PS.K.DMV....RGLVYHYAVADEISVAKAYMYK.Q.G.V.LGaaglYEH....L.....K........AK...S...E..ERFAsym.....lthgE---YFREaaftea....dieevkmNLDKLWGYE..AS..QMA..ASIKAIL...SKQ....PRIGID...A..LVHTA......IP..V.I.VEQKID.GSALGLSTHLSVDA-FSFDS.......I.I.L..DLK.T......GE.....EKE.....F.....HKLSTTGYALVYESIF.EYPINVGCVVYV..NF.SNNSpvpIIKRVPH....LIDETLR.REFLEARDLRMKMIYDRRD...P.G..LP.R...KCY.AK..CQYLRHCG--vg.......................................
A1HNE2_9FIRM/1-306                  ...............................................myfltdderk--------..MFL..KKMLPKARRLDIDEELRGWNWHQAPLEPVYE.ERLAVYEVSSGYCPTSRDLYLR.RVLKNKLK..PN.F.FMI....SGRVFHQIIVDVMENAKKQIYY.H.G.T.YA....PEK....L.....M........AA...L...R..QPIAikw.....pddlN------Llsaeq......sqdiktKGNFLRDYE..QS..RIA..ARIGEIL...TQQ....PYIGAD...S..LAHLA......IP..L.V.CENKLD.GRFLGLSQYLSADALILSEP.......M.I.I..DLK.F......GT.....PQK.....Y.....HRLSTTGYALAMEALY.EVPVNLGCIVYG..EFrNGRL...IVTKDMH....LIDDELR.QWFIESRDNKMRMICEEID...P.G..IA.E...GCY.EY..CPGYEFCH--q........................................
Q8ZZU0_PYRAE/1-286                  .........................................................MFREFRMV..RGL..--------RVEVGEELRGWRWGEPPVQPPPLgVRLSVSDIVGGGCESRRDLYLK.RVLGVRAE..PN.G.GMK....FGAYIHEVFKRSLAELRSLIEG.G.A.V.KG....WEL....V.....Q........SF...N...A..EAIAr..........eAAIAAEAEa..............dpRGVELARYL..AI..QVA..ARVDEIA...SR-....SSADSL...S..IAARA......VP..V.L.AEYVID.GRPLGLT-LVRADA--LYYN.......V.V.V..EIK.V......GS.....YSE.....R.....HALALAGYALAIEADE.EVPVDAGLLISV..AF.NGGV...KLRAYPV....AIGEGLR.REFLEERNRLMELVASGSD...P.G..LS.P...KCD.DK..CPLWRHCHG-g........................................
E0STX3_IGNAA/31-131                 ................................................fvrwfdmlp--------..RWV..WDYVRATAGDGMYAEVRGWRFDV--VGSRFR.ARPSISEVA-SPCPTKRDVYLR.RVLHTYVD..-S.Q.VLR....LGRAVHEVFLLPFR--------.-.-.-.--....---....-.....-........--...-...-..----............--------.................---------..--..---..-------...---....------...-..-----......--..-.-.------.--------------------.......-.-.-..---.-......--.....---.....-.....----------------.------------..--.----...-------....-------.-------------------...-.-..--.-...---.--..----------yrgrdiewlygm.............................
W7KGY0_9CREN/1-268                  .........................................................-------M..RQL..RRLHSYRASDPIDEDLRGWNYHSPPIKPRAY.LSLSVADVAYRYCDSKRDVYLR.KVLKMKGE..QT.P.SLT....LGQQVHELIALISRDVTRLLAQ.G.L.P.AY....EVL....E.....V........IN...K...-..KRYN............TAFNPFLE.................KFKKAFAFY..--..---..-------...---....-LLSDA...S..DSSGF......IP..L.I.SEFRVD.GTPLGLSPRLSADA-ISQLS.......M.V.V..EVK.V......AN.....YQD.....F.....HKLALAGYALALESAF.ELPVDFGALIYV.nGI.NEKY..pEIRTEAH....YLSTDLR.KEFIDARDEVIDMLLEEKD...P.G..LA.S...NCQ.SS..CPFYSYCR--r........................................
F6B8W8_DESCC/1-303                  ................................................myflsdeek-------K..HLL..KNYLPRSRQADTAEELRGWNWHQPPLLPPYE.TKLGAYEIAGAYCPSNRDLYLR.RVQKIKSL..PS.L.AMI....RGYFLHDVLVKELSRAKKIIYH.R.G.V.PG....YKE....I....fN........DL...E...Q..GQDY............KLPDQFQVnkkdk.......lylekEADIIAKFE..RQ..RLA..AKIHDVL...VKQ....PYIGED...S..LVNLA......VP..V.V.LEQKLD.GSFLGMSSHLSVDAYTFSEP.......M.V.M..DLK.F......GE.....KRK.....F.....HRLQTTAYALAMEAVY.EFPVNLGCIVYA..KI.KDDR..lIIEKDIH....IIDDELR.QWFIEERDEKLRMIEEEID...P.G..V-.K...ECP.DS..CHIRQLC---y........................................
B1I4M0_DESAP/7-311                  ..................................................yflteee------KK..HLL..KGLLPRSRELGIAEELRGWNWPAPPLQPVYD.TVLALYEVANSYCPTNRDLYLR.RVRRVFPA..PS.A.AMV....QGRVLHAALVHVLVSAKRLIYS.V.G.V.AQ....YQT....I.....CrelqelgpVN...V...E..SELQ...........aLAPEDAADl..............krKVAIVTEFE..KA..RII..SRIQEIL...FKQ....PYIGED...S..LAVLA......IP..V.I.VEQKLD.GSFLGLSPNLSTDAFTVCEP.......M.I.V..DLK.F......GE.....RRD.....F.....HRLTTTGYALVMESLY.EFPVNIGCLVYG..SF.RGDR..lIINKDLH....IIDDELR.QWFIESRDEKARMVYEEID...P.G..FP.A...ECY.QG..CHCYAACHG-.........................................
A0A0F7FGX1_9CREN/4-310              ........................................................l-FPIIEDI..NSL.yRDFRRM-PPVEVSEELRGWSYGQGVVAPPGG.PLLGVSDITGGFCDRGRDVYLR.YVKRVQPR..DN.Y.LLQ....RGRLIHETWTRTIVEVKRSIYN.H.G.L.DA....SIQ....E.....L........AN...T...A..STLK...........eKLKAEFNAkhslvp.....eeertwLVDRIINEG..FS..TYA..SSLERQL...SRS....RFLEID...G..LVAAT......VP..L.L.TEYPLN.GEKIGLSRALRIDALIP-PG.......L.I.L..ELK.T......RH.....PRR.....E.....FELALVGYALAFESEY.EIPIDRGLLMYV..EV.DPPKrrlYVRPRII....ALGDALR.SEFVERRDKLLELILYDED...P.G..VS.S...NCP.SE..CPYIHYCRG-g........................................
D9PZC8_ACIS3/1-262                  ...................................................mlqllr--------..QEL..KYLHGL--QLSVPSELRGWAWDRPPVRPRYR.AGLGVAEVAYYSCCPREALE-A.RLRGPRQD..--.A.AML....LGAAVHELFRRVAYGLQGLVGR.G.V.E.PW....EAA....R.....R........VM...E...S..RAYA............EVASQLGLa...............gEAQRLRD--..LQ..GAL..AVMLAGD...ATL....QRLLGG...S..ATGSW......AP..W.L.SEYVVD.GTPLGLARRLRVDA--LMSG.......A.V.V..EFK.V......GQ.....ARD.....W.....HAVQMAGYAMALESQL.EVPFDYGLLVSV..SL.SPP-...SLSVHGL....LLGEGPR.SRFLEARDSMAEE------...-.-..--.-...---.--..----------lassgv...................................
A0A2R4ZSS2_9CREN/7-298              .........................................................MLTRLEII..RGL..KKLHTIRARDPVPEELRGWSHNTPPVKPRAY.LGLGVGEIAYRYCETKRDLYLR.RVLGIKGD..SGkA.PLV....NGAAIHKIFSEASRGVRKLALL.G.K.PgPE....IYE....E.....L........SK...E...A..PRIAs..........tTCPEDLRI.................TCEKIYRYL..AL..MWS..AEIAKAR...IA-....-YGSQD...A..AGL--......IP..W.I.TELRVD.GTLVGLSDRLSVDA-IAEAS.......I.V.I..EIK.T......GQ.....KKN.....F.....HKLALAGYALALESSL.ETPIDYGVLIYI.nPV.GEEP...EITLEPH....YISPDTR.KEFIDARDEAIDMILSSKD...P.G..IA.R...NCP.ET..CPFLEICG--vr.......................................
#=GC seq_cons                       ...................................................................p.L..+thh.h.tttsls-ELRGWsWppPPltPhh..htLult-lu.taCsTtRDlYLR.+Vhthcsp..ss.t.thh....tGphlHcshspshtps++hlhp.t.t..........th....................h..........tth.............th.tth.p.................hsphlhph...t...th...uchtphh....p......hhst-...u..lsths......lP..l.h.sE.tlD.GohlGLSptLpsDA.hh..s.......h.l.l..-lK.h......Gp......pc.....h.....HcLslsGYALAhEu.a.EhPV-hGhllYl..ph.pssh...tlphchh....hIs-pLR.ptFlEtRDchhchl.pthD...P.G..hs.p...pC..pt..CPahphC...t........................................
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