#=GF ID Cucumopine_C
#=GF AC PF18631.5
#=GF DE Cucumopine synthase C-terminal helical bundle domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08115
#=GF GA 27.00 27.00;
#=GF TC 27.70 27.60;
#=GF NC 26.70 25.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 26120001
#=GF RT Structural Basis for beta-Carboline Alkaloid Production by the
#=GF RT Microbial Homodimeric Enzyme McbB.
#=GF RA Mori T, Hoshino S, Sahashi S, Wakimoto T, Matsui T, Morita H,
#=GF RA Abe I;
#=GF RL Chem Biol. 2015;22:898-906.
#=GF DR INTERPRO; IPR040602;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC McbB from Marinactinospora thermotolerans is an enzyme that
#=GF CC catalyzes the Pictet-Spengler (PS) reaction of L-tryptophan and
#=GF CC oxaloacetaldehyde to produce the betaC scaffold of
#=GF CC marinacarbolines. This is the C-terminal domain composed of 5
#=GF CC bundled alpha helices. It is weakly similar to the signal
#=GF CC transduction histidine-protein kinase BarA from E. coli and the
#=GF CC DNA endonuclease I-MsoI from Monomastix sp [1].
#=GF SQ 171
#=GS A0A094DUP0_9PEZI/134-283 AC A0A094DUP0.1
#=GS A0A4S3JHT8_9EURO/166-308 AC A0A4S3JHT8.1
#=GS A0A1S2QPG1_9ACTN/11-147 AC A0A1S2QPG1.1
#=GS A0A2V3TYH3_9HYPH/6-144 AC A0A2V3TYH3.1
#=GS A0A4V3T3U1_9ACTN/163-301 AC A0A4V3T3U1.1
#=GS A0A395ICB5_ASPHC/166-308 AC A0A395ICB5.1
#=GS A0A0B2WX55_METAS/167-310 AC A0A0B2WX55.1
#=GS A0A5N6G8U6_PETAA/174-323 AC A0A5N6G8U6.1
#=GS A0A5M3YZS1_ASPTE/170-319 AC A0A5M3YZS1.1
#=GS A0A8J3BWF2_9ACTN/157-297 AC A0A8J3BWF2.1
#=GS A0A1B2I7J7_9BACT/5-157 AC A0A1B2I7J7.1
#=GS A0A1V6SD18_9EURO/171-320 AC A0A1V6SD18.1
#=GS A0A167XBD7_CORFA/166-307 AC A0A167XBD7.1
#=GS A0A4R1NG58_9GAMM/11-154 AC A0A4R1NG58.1
#=GS A0A429FLB2_9ACTN/159-298 AC A0A429FLB2.1
#=GS A0A1G9DHX2_9ACTN/159-298 AC A0A1G9DHX2.1
#=GS A0A2W2E1F5_9ACTN/159-298 AC A0A2W2E1F5.1
#=GS A0A8H4LHN8_9HYPO/167-309 AC A0A8H4LHN8.1
#=GS A0A100IQZ5_ASPNG/166-313 AC A0A100IQZ5.1
#=GS Q0CMX5_ASPTN/174-323 AC Q0CMX5.1
#=GS Q13WR5_PARXL/155-292 AC Q13WR5.1
#=GS M7T6U4_EUTLA/185-326 AC M7T6U4.1
#=GS A0A5N6G6I4_PETAA/128-277 AC A0A5N6G6I4.1
#=GS A0A1I3JMX6_9FIRM/7-108 AC A0A1I3JMX6.1
#=GS A0A317X7F3_9EURO/169-318 AC A0A317X7F3.1
#=GS A0A2V5I3W1_ASPV1/180-322 AC A0A2V5I3W1.1
#=GS A0A8J8HG64_9ACTN/3-136 AC A0A8J8HG64.1
#=GS A0A0B8NHZ9_9NOCA/1-132 AC A0A0B8NHZ9.1
#=GS A0A1T4SNX3_9HYPH/3-142 AC A0A1T4SNX3.1
#=GS A0A0A2VCH0_BEABA/165-314 AC A0A0A2VCH0.1
#=GS A0A395HXG5_ASPHC/211-278 AC A0A395HXG5.1
#=GS A0A416R2F3_9FIRM/3-143 AC A0A416R2F3.1
#=GS A0A372M3N9_9ACTN/159-297 AC A0A372M3N9.1
#=GS A0A4R1NFM2_9GAMM/6-146 AC A0A4R1NFM2.1
#=GS A0A845SBD7_9GAMM/155-292 AC A0A845SBD7.1
#=GS A0A8H7NQV0_BIOOC/96-239 AC A0A8H7NQV0.1
#=GS V6MEU9_9BACL/5-145 AC V6MEU9.1
#=GS A0A4S3J152_9EURO/170-319 AC A0A4S3J152.1
#=GS A0A1F5LSJ7_9EURO/147-284 AC A0A1F5LSJ7.1
#=GS E4NJY1_KITSK/156-294 AC E4NJY1.1
#=GS Q13WR6_PARXL/8-148 AC Q13WR6.1
#=GS A0A4V2JHP7_STRKA/163-301 AC A0A4V2JHP7.1
#=GS A0A7W9GEY9_9ACTN/159-298 AC A0A7W9GEY9.1
#=GS A0A319D6N2_9EURO/168-317 AC A0A319D6N2.1
#=GS A0A317VK48_9EURO/170-319 AC A0A317VK48.1
#=GS S9R046_9RHOB/9-146 AC S9R046.1
#=GS A0A0P4R4A5_9ACTN/163-301 AC A0A0P4R4A5.1
#=GS A0A501WE82_9RHOB/3-142 AC A0A501WE82.1
#=GS A0A395HXG5_ASPHC/153-216 AC A0A395HXG5.1
#=GS G3XW21_ASPNA/191-340 AC G3XW21.1
#=GS A0A1E4QSF3_9BURK/20-143 AC A0A1E4QSF3.1
#=GS A0A1L9UEL1_ASPBC/192-341 AC A0A1L9UEL1.1
#=GS A0A484KHA3_9ASTE/164-305 AC A0A484KHA3.1
#=GS A0A8H6A9V1_ASPBU/174-323 AC A0A8H6A9V1.1
#=GS A0A438M7L5_9ACTN/159-298 AC A0A438M7L5.1
#=GS A0A2V3UH10_9HYPH/155-292 AC A0A2V3UH10.1
#=GS A0A2X0K202_9ACTN/163-301 AC A0A2X0K202.1
#=GS A0A7U3VSU5_9ACTN/165-311 AC A0A7U3VSU5.1
#=GS A0A3D8QXS8_9HELO/165-306 AC A0A3D8QXS8.1
#=GS A0A2V3UDQ2_9HYPH/5-156 AC A0A2V3UDQ2.1
#=GS A0A1M3TEQ7_ASPLC/175-324 AC A0A1M3TEQ7.1
#=GS A0A2I1CF61_ASPN1/190-290 AC A0A2I1CF61.1
#=GS A0A428PCT8_9HYPO/167-309 AC A0A428PCT8.1
#=GS A0A2N7WP39_9BURK/8-148 AC A0A2N7WP39.1
#=GS A0A2C5Z1C2_9HYPO/169-318 AC A0A2C5Z1C2.1
#=GS A0A2I2GLR1_9EURO/170-319 AC A0A2I2GLR1.1
#=GS A0A5M3Z3V1_ASPTE/174-323 AC A0A5M3Z3V1.1
#=GS A0A2A9CT30_9ACTN/4-143 AC A0A2A9CT30.1
#=GS A0A1H6ESC6_9ACTN/159-298 AC A0A1H6ESC6.1
#=GS A0A2I2KJI7_9ACTN/5-144 AC A0A2I2KJI7.1
#=GS A0A2V3TU06_9HYPH/11-155 AC A0A2V3TU06.1
#=GS A0A1H1KMH2_9HYPH/3-143 AC A0A1H1KMH2.1
#=GS A0A395I1N2_ASPHC/169-318 AC A0A395I1N2.1
#=GS A0A7Y8WXV5_9ACTN/157-299 AC A0A7Y8WXV5.1
#=GS A0A2N7X6H5_9BURK/8-148 AC A0A2N7X6H5.1
#=GS A0A1B6APK6_9ACTN/163-301 AC A0A1B6APK6.1
#=GS A0A7K0C408_9ACTN/159-298 AC A0A7K0C408.1
#=GS A0A2V3UEW0_9HYPH/8-148 AC A0A2V3UEW0.1
#=GS A0A4R1NI09_9GAMM/3-142 AC A0A4R1NI09.1
#=GS A0A5S4FEN2_9ACTN/159-298 AC A0A5S4FEN2.1
#=GS A0A415E7K8_9FIRM/1-133 AC A0A415E7K8.1
#=GS A0A1Q9CR98_SYMMI/193-341 AC A0A1Q9CR98.1
#=GS A0A221P4C8_9ACTN/157-297 AC A0A221P4C8.1
#=GS W0HU54_9GAMM/3-142 AC W0HU54.1
#=GS A0A2C5YIR8_9HYPO/171-298 AC A0A2C5YIR8.1
#=GS A0A507B4F3_9PEZI/165-308 AC A0A507B4F3.1
#=GS A0A416R252_9FIRM/4-145 AC A0A416R252.1
#=GS A0A1X0WGJ8_9GAMM/3-143 AC A0A1X0WGJ8.1
#=GS A0A4R1NFB0_9GAMM/155-292 AC A0A4R1NFB0.1
#=GS A0A2P8B3K1_9ACTN/158-298 AC A0A2P8B3K1.1
#=GS A0A379JHC0_9NOCA/163-301 AC A0A379JHC0.1
#=GS A0A2V1HQR4_9MICO/2-141 AC A0A2V1HQR4.1
#=GS A0A401KQW6_ASPAW/169-317 AC A0A401KQW6.1
#=GS A0A1L9PH91_ASPVE/169-318 AC A0A1L9PH91.1
#=GS A0A428P793_9HYPO/166-309 AC A0A428P793.1
#=GS A0A2V3TUD7_9HYPH/4-143 AC A0A2V3TUD7.1
#=GS A0A8E0QPB5_9EURO/163-308 AC A0A8E0QPB5.1
#=GS A0A7G9B2X9_9FIRM/162-302 AC A0A7G9B2X9.1
#=GS A0A7W5VJ62_9ACTN/160-299 AC A0A7W5VJ62.1
#=GS A0A7W8EM87_9ACTN/163-302 AC A0A7W8EM87.1
#=GS A0A6L5F3F5_9ACTN/154-291 AC A0A6L5F3F5.1
#=GS A0A7K2YFC1_9ACTN/162-300 AC A0A7K2YFC1.1
#=GS A0A1V6PPY8_9EURO/171-320 AC A0A1V6PPY8.1
#=GS B6GZM6_PENRW/171-320 AC B6GZM6.1
#=GS A0A1L9X796_ASPA1/185-327 AC A0A1L9X796.1
#=GS A0A2K8PJ52_STRLA/165-303 AC A0A2K8PJ52.1
#=GS A0A416R2D5_9FIRM/3-144 AC A0A416R2D5.1
#=GS A0A1R3RTX7_ASPC5/170-319 AC A0A1R3RTX7.1
#=GS E4NIM4_KITSK/2-136 AC E4NIM4.1
#=GS A0A2V3TWM1_9HYPH/11-153 AC A0A2V3TWM1.1
#=GS A0A2S4YLH9_9ACTN/163-301 AC A0A2S4YLH9.1
#=GS A0A1L9TPY1_9EURO/164-313 AC A0A1L9TPY1.1
#=GS D8MR06_ERWBE/3-144 AC D8MR06.1
#=GS A0A093XTM2_9PEZI/152-301 AC A0A093XTM2.1
#=GS A0A2V1HQ85_9MICO/4-143 AC A0A2V1HQ85.1
#=GS A0A1G9AR34_9ACTN/159-298 AC A0A1G9AR34.1
#=GS A0A2A9CVD2_9ACTN/14-154 AC A0A2A9CVD2.1
#=GS A2R024_ASPNC/175-324 AC A2R024.1
#=GS A1DKD0_NEOFI/163-308 AC A1DKD0.1
#=GS A0A5D0Q6S8_9ACTN/159-298 AC A0A5D0Q6S8.1
#=GS A0A101NH40_9ACTN/163-301 AC A0A101NH40.1
#=GS A0A4R4N9U5_9ACTN/159-298 AC A0A4R4N9U5.1
#=GS A0A1I0KMN8_9ACTN/158-297 AC A0A1I0KMN8.1
#=GS A0A8J8H9F8_9ACTN/162-302 AC A0A8J8H9F8.1
#=GS A0A2I2GLI6_9EURO/167-308 AC A0A2I2GLI6.1
#=GS A0A5C4WNV5_9ACTN/159-298 AC A0A5C4WNV5.1
#=GS A0A1H3PEK4_9MICO/14-154 AC A0A1H3PEK4.1
#=GS E7GHY3_CLOSY/3-142 AC E7GHY3.1
#=GS A0A2N7WPA8_9BURK/11-153 AC A0A2N7WPA8.1
#=GS A0A5J6F5H2_9ACTN/159-297 AC A0A5J6F5H2.1
#=GS A0A319CIC9_9EURO/185-327 AC A0A319CIC9.1
#=GS A0A8H6A7E4_ASPBU/144-272 AC A0A8H6A7E4.1
#=GS A0A5C8K2B9_9ACTN/158-297 AC A0A5C8K2B9.1
#=GS A0A3F3PVF1_9EURO/191-340 AC A0A3F3PVF1.1
#=GS A0A2N6NNU9_BEABA/165-314 AC A0A2N6NNU9.1
#=GS A0A1E3H425_9HYPH/3-142 AC A0A1E3H425.1
#=GS A0A6G4U1J3_9ACTN/163-301 AC A0A6G4U1J3.1
#=GS A0A6P1ITC5_9BURK/3-141 AC A0A6P1ITC5.1
#=GS A0A7X0HJN3_9ACTN/162-300 AC A0A7X0HJN3.1
#=GS A0A5N5XHS6_9EURO/174-323 AC A0A5N5XHS6.1
#=GS A0A5N6G6A3_PETAA/179-257 AC A0A5N6G6A3.1
#=GS A0A2T0MRK1_9ACTN/159-298 AC A0A2T0MRK1.1
#=GS A0A0L1JGF9_ASPNO/162-305 AC A0A0L1JGF9.1
#=GS A0A5N5WI31_9EURO/126-275 AC A0A5N5WI31.1
#=GS A0A8J6J384_9FIRM/3-142 AC A0A8J6J384.1
#=GS A0A1J7C6Q4_9GAMM/3-142 AC A0A1J7C6Q4.1
#=GS A0A416RDE6_9FIRM/5-102 AC A0A416RDE6.1
#=GS A0A1E4QSE9_9BURK/62-204 AC A0A1E4QSE9.1
#=GS A0A3M2SLG7_9HYPO/166-309 AC A0A3M2SLG7.1
#=GS A0A416R2B2_9FIRM/4-145 AC A0A416R2B2.1
#=GS J4W1X7_BEAB2/165-314 AC J4W1X7.1
#=GS W0HZB1_9GAMM/11-154 AC W0HZB1.1
#=GS A0A845SLI6_9GAMM/6-146 AC A0A845SLI6.1
#=GS A0A1U9ZVA9_9ACTN/159-298 AC A0A1U9ZVA9.1
#=GS A0A1M6LRX5_9ACTN/160-300 AC A0A1M6LRX5.1
#=GS A0A484K5H0_9ASTE/163-304 AC A0A484K5H0.1
#=GS A0A7V8NFV1_9ACTN/163-301 AC A0A7V8NFV1.1
#=GS A0A840P7I0_9ACTN/156-295 AC A0A840P7I0.1
#=GS A0A093XQP8_9PEZI/168-317 AC A0A093XQP8.1
#=GS A0A7W9PNJ9_9ACTN/163-301 AC A0A7W9PNJ9.1
#=GS S3C888_9ACTN/157-297 AC S3C888.1
#=GS A0A845SLX8_9GAMM/3-142 AC A0A845SLX8.1
#=GS A0A812U011_9DINO/194-341 AC A0A812U011.1
#=GS A0A545URT9_9HYPO/165-314 AC A0A545URT9.1
#=GS A0A6I4MBU2_9ACTN/159-298 AC A0A6I4MBU2.1
#=GS A0A401KD22_ASPAW/303-450 AC A0A401KD22.1
#=GS A0A1T4SMS8_9ACTN/160-300 AC A0A1T4SMS8.1
#=GS A0A0L8QUW3_9ACTN/157-297 AC A0A0L8QUW3.1
#=GS A2QLY6_ASPNC/156-285 AC A2QLY6.1
#=GS A0A2A9CT44_9ACTN/4-143 AC A0A2A9CT44.1
#=GS A0A1H0TG68_9ACTN/177-315 AC A0A1H0TG68.1
A0A094DUP0_9PEZI/134-283 ....................VKELVQEIHNETEKS.WS.GISTDL.KLV.HRGLAK..ASP..G..S..KDSYFATMVFINGEI..RPLGYN....VL.NGTLKIAATQ.pGY......SLEHLIGIYRVFALT...P...S...E...FVG............Y...T...G...ANFLCSTHNKIEELIekvvernqNQ.VV.AREDFLAMVSAFALYVNLLNAQNLHL....................
A0A4S3JHT8_9EURO/166-308 ...............wrdak-----ELIEMEVDRV.WI.TKPDEI.KKI.SWGIID..SGA..G..S..GEQYFSVMVHLKSFL..LHLGCD....VL.YRLLKVSKYD..EV......LLPTLIRMTREFLEE...N...FntfE...MLS............D...L...G...LDSMRHVGASYSKAL........PT.LG.NKEEYRQLTGVLFTYVCRMHRW-VH-f...................
A0A1S2QPG1_9ACTN/11-147 ...............araws------ELRSLTAHL.LA.REPEEI.HAL.RTGALP..HRP..G..S..YGQYFTAWDLANGIL..RDYSMN....LY.QALRMVARR-..EI......GVDSALAVLRSWVPM...Y...G...E...FLR............Y...S...G...FERLADHARLMVE--........SG.VR.DHRGLVAELSALVAYVNRLTAWSHHY....................
A0A2V3TYH3_9HYPH/6-144 ....................VQAVVAMIDAETAAI.LN.QEPEEA.RKL.REGRLD..DKA..G..A..YGQYFGTWDIAAGML..RDCSMY....AL.YPLLRLARQQ..RS......DLN-IAAMADEMLPP...Y...T...N...YLG............Y...S...G...FPTLERLGDALRPVL........RE.A-.TPEEADALLSAYLRYANRLYCWVYHY....................
A0A4V3T3U1_9ACTN/163-301 ...................a-ARLIADIVAETEKI.WL.APPAEL.DDL.HRGIIP..SRA..G..N..FGTVLPTLLFVNGET..RPLGYA....AY.GGLVR-ANVQ..GM......PMASLAHMARLLVGV...P...A...E...FLG............Y...C...G...LEKLWAFTQRFFDVI........DD.L-.DRDDFYAVTSQMALYINCLGGWNLQL....................
A0A395ICB5_ASPHC/166-308 ...................w-REAASIISAQVDRV.WI.HEPEDI.KKI.SWGIID..SGA..G..S..GEQYFSVMVHLKSFL..LHLGCD....VL.YRLLKISQYE..EI......ALPVLRRMTREFLEQ...N...FntfE...MLT............D...L...G...LSDMGEIGDVYLHGL........AS.LT.SKDDYRSLTGVLFTYVCRMHRW-VH-f...................
A0A0B2WX55_METAS/167-310 ...............yrqvk-----TLIEEEIDRI.WL.DEPAEF.QKV.RWGVID..SGA..G..T..GEQYFTVMVHLEAYL..MVVGGD....VM.YRFLKLAEYH..DI......ELPALNRLTREFLVG...N...F...D...MFE............F...MadlG...LPSMHKIGQEYSDAL........ST.LK.TKEEYVELTGAMQTYMNRMHRWSY--fi..................
A0A5N6G8U6_PETAA/174-323 ....................VKDLVDEIHKETQKS.WS.DISDSI.KKI.HHGEAP..EKP..G..S..KESYFGAMVFSNSVV..RTLGYH....IF.DNILKLAVTR.pEF......TLQHLIILFRDLIPS...I...A...D...FIG............H...L...G...VEFLCESYWKVDKLVkekvesnpNQ.EE.AREDFLAMISALAFYVNLLNAQNLHM....................
A0A5M3YZS1_ASPTE/170-319 ....................VRKIVQEIYVEVGNS.LV.LFLELI.ATI.HKGLAP..SGA..G..S..KGSYFQTMVFLQGQV..RALGYT....VL.NNLVRMEATQ.pQF......SLQHLITMYRVLASP...I...V...E...FCG............Y...M...G...TGFLLDIHEKIDAAIkrsvennpDQ.QE.AREDFLAMICAFAQYVTLLNAQNLQL....................
A0A8J3BWF2_9ACTN/157-297 ...................l-RPLIERIAQETEKV.LV.APTDEL.IDM.HEGTFF..SGA..G..T..KNSVLTTLVAVNGET..RPLGYV....SY.AGLVRAARLT..ET......PLKSLVALARILLVK...P...S...E...FLG............Y...C...G...MDTLWEFTKEVNAAL........DQ.IA.TREDFAALMAQMTTYVNALGAWNLQL....................
A0A1B2I7J7_9BACT/5-157 ................wvdv----KEMIEAEIDKN.WW.EEPIEV.RMS.RNGVFP..SGA..G..S..HGQYLGNLFFLVSDT..QAMGWW....TA.APAIQQALRD.dSF......TLDHCKKMWIYINKH...M...C...H...LMGdstgagtncpapW...L...N...LPKFSEFCDAIIDSF........DS.IN.TKDEFWDLIWSWQNYANCMNRW-FQM....................
A0A1V6SD18_9EURO/171-320 ....................VKDIVQEIHNEMDKT.WS.GISDDV.STI.HCGRAP..DYP..G..S..KSSYFAAMLFANSEV..RTLGYY....VL.DNILKIAANH.pRF......DLRHLVVLYRELVSV...P...A...E...FLG............Y...V...G...TEFLRNSHRKIDELIklnvernaNQ.EE.AREDLLAMVSVLAQYINLLNAQNLHL....................
A0A167XBD7_CORFA/166-307 ...............eakal-------IEKEIDHI.WL.EEPVEF.QKV.RWGVID..SGA..G..T..GEQYFTVMVHLEAYL..MVIGGD....AM.YRFLKLAQYD..DI......PLPALNRLTREFLVG...N...F...D...IFE............FmadL...G...LPSMHEIGQKYSDAL........SA.LQ.TKDEYIELTGAMQTYMNRMHRWSY--fi..................
A0A4R1NG58_9GAMM/11-154 ...............wrdak-----AIIEKEIDRV.WL.HEPEEI.QKI.RWGIID..SGA..G..S..GEQSFSVLVHLEAYL..MLVGAD....VM.YRFLKISQYD..DM......QLPTLNRITREFLTA...T...F...N...VFE............F...MtdlG...LTNMHAMGQMYSDAL........DT.LA.TKEEYVELTGAMMTYVIRMHRWIH--yi..................
A0A429FLB2_9ACTN/159-298 ...................v-DALIGKVHAETERV.WT.HPPEEL.VEL.HEGRIA..SRA..G..S..FDTVLTTLLFVNGET..RPLGYC....AY.GGLVRAAAE-..EM......PLDCLRQMARILTAT...P...A...E...FLG............Y...C...G...LETLHHFTESALDAA........GR.IE.RRTDFLALMAQMALYVNCLGGWNLQL....................
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A0A5S4FEN2_9ACTN/159-298 ...................l-NALAADVHAETERI.WL.DPPREL.IDL.HQGRIT..SGA..G..S..YETVLTTLLFVNGET..RPLGYS....CY.GGLVRAALD-..GM......PMPWLRQMTRQLAHT...P...A...E...FLG............Y...C...G...LDTLWGFTQRLLDGL........ER.LD.CHEDFVAVMAHMALYCNCLGGWNLHL....................
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A0A7K2YFC1_9ACTN/162-300 ...................a-KQLIRDVYTETERI.WL.TEPLEL.ADL.HGGWIP..SGA..G..S..FETVLPTLLFVNGET..RPLGYA....TY.GGLVRAAVA-..DM......PMDSLRHMARLLIGI...P...A...E...FLG............Y...C...G...LEKLWAFTQRFLSCL........DR.L-.DRDDFLAVASQLALYINCLGAWNLHL....................
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A0A416R2D5_9FIRM/3-144 ..................wk--TVKKTIDEENARI.LK.TPPEDV.LRVfKYEILE..TEG..G..T..GGLMLGPWFEGATAS..RYVGPY....YV.YNIVKLAGLP..GY......TAQQVKEMTFQLLPK...A...V...G...TAK............L...C...G...MATYAELAQKVLDCM........KD.LD.TKEDMLKLLNALYLYGSNMNAWIHH-y...................
A0A1R3RTX7_ASPC5/170-319 ....................VRDIVREIHDEMDKS.WS.GISADI.DMI.HCGQAP..DNP..G..S..KSSYFAAMLFANSEV..RTIGYY....VL.DNILKIAATH.pEF......DLRHLIVLYKEFVSV...P...A...E...FLG............Y...V...G...TEFLRNSHRKIDGLIksnvegnaNQ.EE.AREDLLAMVSVLAQYVNLLNAQNLL-l...................
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A0A319CIC9_9EURO/185-327 ...............whsah-----TTITAQTNTI.WL.HLPVSI.QKI.TWGLIP..SGA..G..T..GNQCFSVLVHLKSFL..LHLGCD....VL.YRLLKISRYP..DI......PLGVLQRMTREFLSA...N...FntfE...MLV............D...L...G...LDEMGVIGEVYLRGI........GA.VA.CKEEYRALTGALFTFVCRMHRW-VH-f...................
A0A8H6A7E4_ASPBU/144-272 krlvqeindeamefyicsrt----------PTEKF.WS.SVSADL.SIV.HRGMTP..SRA..G..S..KGSYFATMVFINGEI..RPLGYN....LL.NNILSMAATQ.pRF......NLEHHITLYRVFTCT...P...A...E...FVG............Y...V...G...GKHLHSTYRKIDDLI........NS.S-.--------------------------iqdn................
A0A5C8K2B9_9ACTN/158-297 ...................i-DALIGDVHAETERI.WL.SPPDDL.ADM.HEGRIP..SCA..G..S..FETVLTTLVFVNGET..RPLGYS....CF.TGLVRAAYE-..EM......PLESLRHMAQLLAAT...P...A...E...FLG............Y...C...G...LGKLHDFTTRALAGL........DR.ID.NRDDFAALMAHLALYVNCLGSWNLQL....................
A0A3F3PVF1_9EURO/191-340 ....................VRNLVEEIHTETQKC.WS.DISDDI.EEI.HYGNAP..EKP..G..S..KDSYFGAMVFSNSVV..RTLGYH....VI.DNIIKLAFTR.pEF......TLGHLIALFRDFVPS...I...A...D...FVG............H...L...G...AEYVNDIYERIDKLIkekveknpNK.EE.AREDFLAMISAFSFYVNLLNAQNLHM....................
A0A2N6NNU9_BEABA/165-314 ....................IRDLVAAIHQETEAS.WS.GISKDL.AKV.HQGLSP..SLA..G..S..KGSYFATMVFINGEI..RPLGYN....VL.NNILKVAATQ.pNF......DLEQLAALYTVFASV...P...S...E...FVG............Y...T...G...ANYLFSTHEAITAMIkksvlqnrNK.ED.AREDLLAMVSAFAKYVNLLNAQNLH-v...................
A0A1E3H425_9HYPH/3-142 ....................VKEVIDELDAEREKI.WL.TCPDEV.KDI.GQGIVP..RGT..G..S..RGQYFSTLVFAEGEA..RTLADE....ML.WGIIQVCEKP..DA......DLGTLKHVISEIIGY...K...A...D...FFD............F...V...G...LPHAAAMIHKYVAAA........QE.CG.TLDELKALSSACLTYANRVHMW----vda.................
A0A6G4U1J3_9ACTN/163-301 ...................a-SSLIADVAAETEKI.WL.APPVEL.DGL.HQGIIP..SQA..G..N..FGTVLPTLLFVNGET..RPLGYA....AY.GGLVRAAVQ-..GM......PMDSLVHMARLLVGV...P...A...E...FLG............Y...C...G...LEPLWAFTQRFLDVV........DR.L-.DRDDFYAVTSQLALYINCLGGWNLQL....................
A0A6P1ITC5_9BURK/3-141 ..................yl--DLLADLQAETAGI.AR.QEPEGY.RKL.RTGTLE..NRP..G..S..EGAYFGALDIAHGML..RDFAMY....TV.YPTLALHREQ..-H......DVGVSRAVVRQMFPT...V...L...N...YLG............Y...S...G...FPEMKRLGHQLLEVS........GH.C-.DWAQFEQLLVAFLRYVNTLYAWCYH-w...................
A0A7X0HJN3_9ACTN/162-300 .................adl---LIQDIYNETERN.WL.TAPPEL.ADM.HQGWIP..SRA..G..T..HDTVLPTLLFVNGET..RPLGYA....SY.GGLIRAAVA-..DM......PMASLHQMTRILVGV...P...A...E...FLG............Y...C...G...LEKLWDFTQRFLDCL........DD.L-.DRDDFLAVTSQVALYINLLGAWNLHL....................
A0A5N5XHS6_9EURO/174-323 ....................VRSLVEEIHKETEKS.WS.GVSEGI.DKL.HHGQAP..EKP..G..S..KNSYLGTMLFSNSVV..RTLGYH....IF.DNIIKLSATR.pEF......TLQHLIILFRDLIPS...I...A...D...FIG............H...L...G...EEFLCDSYWKVDNLIkqnvennpNE.EE.AREDFLAMVSAMSFYVNLLNAQNIHM....................
A0A5N6G6A3_PETAA/179-257 ..........nnilkvvath---------------.--.------.---.------..---..-..-..---------------..------....--.----------..--......--------PDELVTV...P...A...K...FLG............Y...V...G...TEFLCESHPKIDNLIrlngegdpNQ.EV.AREDFLAMVSVLAQYVNLLNAQNLNM....................
A0A2T0MRK1_9ACTN/159-298 ...................l-NRLVTEVHAETQRI.WL.EPPQEL.LDL.HEGRIP..SGA..G..S..YETVLTTLLFVNGET..RPLGYS....CY.GGLVRAALD-..GM......PMPWLRQMTRQLAHT...P...A...E...FLG............Y...C...G...LDRLWDFTQRLLAGL........ER.LD.SHEDFVAVMAHMALYCNCLGGWNLHL....................
A0A0L1JGF9_ASPNO/162-305 ..............wratkk------LIEKEIDRI.WL.DEPEEI.QKI.RWGVID..SGA..G..T..GEQYFTVLVHLEAFL..MVLGGD....LM.GRFLKIAQDD..DV......RLTTLNRITKEFLVE...R...F...D...LFE............FmgdL...G...LPSMLKIGGMFATAL........DT.LE.SKQDYIQLMGTMLTYTNRLHRWSY--fi..................
A0A5N5WI31_9EURO/126-275 ....................VKSIVQGIHNEMDRS.WS.GISDNV.STI.HCGRAA..DHP..R..S..KSSYFAAMLFANSEV..QTLGYY....VL.DNILKIAATH.sEF......HLRHLVVLYRELISA...P...A...E...FLG............Y...V...G...TEFLRDSHRKIDELItlkvepntNQ.EE.AREDLLAMVSVLAQYVNLLIAQNLL-l...................
A0A8J6J384_9FIRM/3-142 ....................WKAAIDKFEERRLAI.WE.NMPHDV.YDL.SNGVVP..GDT..N..V..YGQYVMTALYADSEM..RTLCDE....IL.FYLVETAKEG..SV......DLHTLVRYAKNLLDY...K...A...K...FFK............F...T...G...VPMAGELLNMYIKAL........DS.VE.NLEQLIKLTEAALMYFNRHHMW-V--dl..................
A0A1J7C6Q4_9GAMM/3-142 ....................IDEVIARFEQEREKI.WF.DQPDEV.KAL.GQGIVP..RGT..G..S..RCQYLSTIIFAEGEA..RTMADE....ML.WGLIRVAEDT..DA......DLKTLQSLIKEIIGY...K...A...D...FFD............F...V...S...LPHAASLIHLYVDTA........CR.CT.TLEELCRLSHAALSYANRLHMW-V--df..................
A0A416RDE6_9FIRM/5-102 ....................WRDVKAEIEAEIDKI.WF.DEPLEL.TLS.KRGIFP..SGA..G..A..HQQAFGNFVFLFADT..HAIGGF....VIeAPMYSFVDNP..SF......TLDHCKTIFTAINM-...-...-...-...---............-...-...-...---------------........--.--.--------------------------nkcrimganhg.........
A0A1E4QSE9_9BURK/62-204 ...................w-KLFIDKVENHINDQ.WL.NEPWEI.TKI.KWGLID..TGA..G..S..GGQFFSVLVHLDIFLeaAKCVIY....AL.AMYVKENSEQ.fQF......TKILLRYILKESFD-...A...F...E...FLK............D...L...G...LAYMQDLGDEYFEAI........DDpAT.GINELFEMSVTFVLD-----------itrifswvks..........
A0A3M2SLG7_9HYPO/166-309 ............wkaakavi--------DAEIAQLrLA.EEPDDI.KLI.RLGAVH..SRA..G..G..ESSPYQTFVFLQGFL..STLGPH....VF.SRLIAVSSYP..EM......TTTLMVRQTREFLTE...T...FnhfD...FLA............D...L...G...LTRTRDVGKLYITAL........ED.VK.TLDEYRSLTDSMRTMIQLLYRW-VH-l...................
A0A416R2B2_9FIRM/4-145 ...................f-KQLKAEIEEQIAVS.SL.EPDQDV.LDVfRYSISK..AGA..GypQ..DNQIFTTWFYGAPDC..-GYVTD....WC.YFLVELARDE..YY......SMEELCKIARFWFVQ...P...S...H...FGE............Y...C...G...LYKQYYFTKEIDKIM........DT.L-.TRQEFVELLSAFRAYIANVNVWVFQY....................
J4W1X7_BEAB2/165-314 ....................IRDLVAAIHQETEAS.WS.GISKDL.AKV.HQGLSP..SLA..G..S..KGSYFATMVFINGEI..RPLGYN....VL.NNILKVAATQ.pNF......DLEQLAALYTVFASV...P...S...E...FVG............Y...T...G...ANYLFSTHEAITAMIkksvlqnrNK.AD.AREDLLAMVSAFAKYVNLLNAQNLH-v...................
W0HZB1_9GAMM/11-154 ...............wqqak-----ALIEAEIDRV.WR.HEPEEI.QKI.RWGIID..SGA..G..S..AEQSFSVLVHLEAYL..MLVGAD....VM.YRFLKISQYD..DL......PLATLNRITREFLTA...T...F...N...VFE............F...MtdlG...LTNMHQIGQMYSDAL........DK.LE.TKEDYVKLTGAMMTYVIRMHRWIH--yi..................
A0A845SLI6_9GAMM/6-146 ..................lg--EVIDHVRRSTATM.AA.EEPAEI.YAF.RTGTLD..NQA..G..S..YGQYFGTWDIAAGMM..RDYSMY....TY.YPLLQVIENP..DI......TLPQFCFILDSFDHP...Y...S...N...YLR............Y...S...G...FPQLGKLALALREWL........PR.AD.SRQQAIEAIRAFCIYTDTFAAWSFHY....................
A0A1U9ZVA9_9ACTN/159-298 ...................l-NRLVTEVHAETERI.WL.TPPQEL.LDL.HSGRIP..SRA..G..S..YETVLTTLLFVNGET..RPLGYS....CY.GGLVRAALD-..GM......PMPWLRQMTRQLAHT...P...A...E...FLG............Y...C...G...LDRLWDFTQRLLSGL........ER.LD.DHEDFVAIMAHMALYCNCLGGWNSHL....................
A0A1M6LRX5_9ACTN/160-300 ....................VQRLIDEMHDATRRS.WT.DPPEEL.VDM.HAGRIG..SRA..G..S..RDQYFSTLVFLNGEV..RPLGYN....AL.NGLVRLVRTT..DL......PLETLREITPGFIRT...P...A...E...FLG............Y...T...G...LHALEDFTGRSVKAL........GA.LE.DREEYFALISTLALYTNMLNTWNLHL....................
A0A484K5H0_9ASTE/163-304 ..............wksvea------LFRHEAKRV.LQ.EEPDEV.FAS.FAGFVP..TGM..G..T..GGNVLPVWMHTWCCL..MTDGPS....TL.YHFLRDSDLP..SM......TLPMMKDLTRYHLLQ...PfnhF...E...FLA............D...L...G...LPKFKAWGKMYSSAL........AD.LE.SLDEYKQLTAALLTLVNVY-------lrrvq...............
A0A7V8NFV1_9ACTN/163-301 ...................a-RRLIHDVHSATERD.WL.SGPQEL.ADL.HAGVIP..SGA..G..S..FDTVLPTLLFVNGET..RPLGYA....TY.GGLVR-ATVQ..GM......PLESLRHMARLMVGL...P...A...E...FLG............Y...C...G...LERLWEFTQRFLGCL........DQ.L-.DREDFLSVVSQLALYVNCLGGWNLHL....................
A0A840P7I0_9ACTN/156-295 ...................v-DALIGDLYAETKRI.WL.EPPEEL.VEL.HEGRVR..SGA..G..S..YETVLTTLLFVNGET..RPLGYA....CY.GGLVRAAQT-..DI......PLPALREMARILAAT...P...A...E...FLG............Y...C...G...LETLWRFTRRTMDLL........DQ.IS.ERDDYTALMAHMALYVNCLGGWNLHL....................
A0A093XQP8_9PEZI/168-317 ....................VKELVREIHNETEKS.WS.GISTDL.KLV.HRGLAK..ASP..G..S..KDSYFATMVFINGEI..RPLGYN....VL.NGTLKIAATQ.pGY......SLQHLIGIYRVFAST...P...S...E...FVG............Y...T...G...ANFLCSTHEKISELIekivernsDQ.VV.AREDFLAMVSAFALYVNLLNAQNLHL....................
A0A7W9PNJ9_9ACTN/163-301 ...................a-DRLLKDVHAETERI.WL.SEPPEL.ADL.HRGWIP..SGA..G..T..YETVLPTLLFVNGET..RPLGYA....AY.GGLVR-AVTG..GM......PLDSLRQMARLLTGV...P...A...E...FLG............Y...C...G...LEKLWGFTQRFLSCL........DR.L-.DREDFLAVASQLALYINCLGGWNLHL....................
S3C888_9ACTN/157-297 ...................a-RDLIERIAAETERV.LI.EPTDEL.VAA.HEGRFD..QGA..G..T..KNSVLTTLVCINGET..RPLGYV....SH.TGLVRAARLT..DV......PLSALVEMAKILLVK...P...T...E...FLG............Y...C...G...LNTLWDLTQDMVALL........AE.TT.SREDFIALMSHMATYTNALGAWNLQL....................
A0A845SLX8_9GAMM/3-142 ....................VDEVIARFEQEREKI.WF.EQPDEV.RDL.GNGIVP..RGT..G..A..RGQYLSTIIFAEGEA..RTMADE....ML.WGLIRVAEDT..DA......DLPTLQSIIKEIIGY...K...A...D...FFD............F...V...S...LPHAAAMIHLYVDTA........CQ.CT.TLHDLCRLSHAALSYANRLHMW-V--df..................
A0A812U011_9DINO/194-341 ...................v-DEAVAFIRSQTRRH.WL.EPPQELvRLL.STGDTR..GQE..G..T..EGYVFPPMVIGNGVM..MVLSTY....AH.SGVLNVLASL.lEKgi.gkdDIFVLQQLVKKVADT...N...L...P...YLR............S...L...S...LDTICGGFDRFFAAW........DQ.AE.TAAQVRTLAGAISLFGALMHGWF---vfl.................
A0A545URT9_9HYPO/165-314 ....................VQDLVAAIHQETEAS.WS.GISKDL.TNV.HQGLSP..SQA..G..S..KGSYFATMIFMNGEI..RPLGYN....IL.NNILKIAATH.pNF......DLEQLAALYTVLASV...P...S...E...FVG............Y...T...G...AKYLFLAHEAISAMIersvllnrNK.ED.AREDLLAMVSAFAKYVNLLNAQNLH-v...................
A0A6I4MBU2_9ACTN/159-298 ...................v-DALIGDVHAETERI.WL.DPPQEL.VDL.HDGRIT..SRA..G..T..HGTVLTTLLFVNGET..RPLGYS....AY.SGLVRAAHE-..GL......PMEPLRRMAHGLIAV...P...T...E...FLA............Y...C...G...LEKLGGFTERLLDGL........DR.LD.RRQDFAAVMAHMALYVNCLGGWNLHL....................
A0A401KD22_ASPAW/303-450 ....................VKNIIQEIHTET--S.WS.GLSQDL.ELI.HKGLAP..SGA..G..S..KGSYYFTMVFLQGQI..RALGYT....VL.NNLVRMAVIQ.pHF......DLQHLVTMYRILASP...I...V...E...FCG............Y...M...G...TGFLLEMHEKIDAAIkhsvennpDK.LE.ARGDFLAMIGAFAQYVTMLNAQNLQL....................
A0A1T4SMS8_9ACTN/160-300 ....................VQKLVEEIQDETERV.WI.TPPAEI.VDM.HQGRIA..SRA..G..S..YDQYFSTLVFLNGEV..RPLGYC....AL.NGLLKICRTT..DL......TLNDLKRITPTFIKT...P...A...E...FLG............Y...T...G...LDTLWRFTQQVLTLL........PD.VE.TREQYFALVNALALYANMLNTWNLHF....................
A0A0L8QUW3_9ACTN/157-297 ...................a-RDLIERIAAETERV.LI.EPTDEL.IAA.HEGRFD..TGA..G..T..KGSVLTTLVCINGET..RPLGYV....SH.TGLVRAARLT..DV......PLSALVELAKILLVK...P...T...E...FLG............Y...C...G...LNTLWDLTQEVVAAI........GE.TS.SKEDFIALLSHMATYTNALGAWNLQL....................
A2QLY6_ASPNC/156-285 .................tsa--------REETETS.WS.GLSQDL.ELI.HKGLAP..SGT..G..S..KGSYFFTMVSLQGQI..RALGYT....VL.SNLVRMAVIQ.pHF......DLQHLVTMYRILASP...I...V...E...FCG............Y...M...V...TRFLLEMHGKIDAAI........KH.S-.--------------------------venspdkleddrcicsaats
A0A2A9CT44_9ACTN/4-143 ...................v-TEVIAELDAERERI.WL.DCPQEV.TDM.GRGRIP..RRT..G..S..HGQYLTTLIFAEGEA..RTLSDE....FL.WGIIELSETE..QL......DLHTLQAIVRQIVGY...K...A...D...FFD............F...V...G...MPQAAGLVHRYVQAT........QV.AE.SLDEFLALTRAAISYVNKLHMW----vda.................
A0A1H0TG68_9ACTN/177-315 ...................a-SHLIADIVAETEKI.WL.APPAEL.DDL.HQGVIP..SQA..G..N..FGTVLPTLLFVNGET..RPLGYA....AY.GGLVRAAVQ-..GM......PMDSLVHMTRLMVGV...P...A...E...FLG............Y...C...G...LEKLWAFTQRFLGVL........DR.L-.DRDDFYAVTSQMALYINCLGGWNLQL....................
#=GC seq_cons ...................h.pplltclcsEs-+h.Wh.s.Pp-l.tcl.+pGhhs..utA..G..S..tsphhsThlFssGph..RsLGhp....sh.ssll+hAtst..ph......sLppLhphh+thsss...s...u...-...FlG............a...s...G...lppLtshspphhssl........sp.hp.s+--ahulhuuhshYlNtLsuWslp.....................
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