#=GF ID   CyRPA
#=GF AC   PF18638.5
#=GF DE   Cysteine-Rich Protective Antigen 6 bladed domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF07858
#=GF GA   38.10 38.10;
#=GF TC   57.40 57.10;
#=GF NC   33.70 19.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Repeat
#=GF CL   CL0186
#=GF RN   [1]
#=GF RM   28195038
#=GF RT   Structure of the malaria vaccine candidate antigen CyRPA and its
#=GF RT   complex with a parasite invasion inhibitory antibody.
#=GF RA   Favuzza P, Guffart E, Tamborrini M, Scherer B, Dreyer AM, Rufer
#=GF RA   AC, Erny J, Hoernschemeyer J, Thoma R, Schmid G, Gsell B,
#=GF RA   Lamelas A, Benz J, Joseph C, Matile H, Pluschke G, Rudolph MG;
#=GF RL   Elife. 2017; [Epub ahead of print]
#=GF DR   INTERPRO; IPR041396;
#=GF DR   SO; 0001068; polypeptide_repeat;
#=GF CC   Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA)
#=GF CC   is a 42.8 kDa protein of 362 residues with a predicted
#=GF CC   N-terminal secretion signal. It is part of a multi-protein
#=GF CC   complex including the PfRH5-interacting protein PfRipr and the
#=GF CC   reticulocyte binding-like homologous protein PfRH5, which binds
#=GF CC   to the erythrocyte receptor basigin. PfRH5, PfCyRPA, and PfRipr
#=GF CC   colocalize during parasite invasion at the junction between
#=GF CC   merozoites and erythrocytes. The complex seems to be required
#=GF CC   both for triggering Ca2+ release and establishment of tight
#=GF CC   junctions. PfCyRPA adopts a 6-bladed beta-propeller structure
#=GF CC   with similarity to the classic sialidase fold, but it has no
#=GF CC   sialidase activity and fulfills a purely non-enzymatic function.
#=GF CC   Each blade of the propeller is constructed by a four-stranded
#=GF CC   anti-parallel beta-sheet [1].
#=GF SQ   52
#=GS A0A024WX65_PLAFA/4-152    AC A0A024WX65.1
#=GS A0A0L7M5R2_PLAF4/33-203   AC A0A0L7M5R2.1
#=GS A0A0L1IAB9_PLAFA/39-353   AC A0A0L1IAB9.1
#=GS K6UU69_PLACD/1-104        AC K6UU69.1
#=GS CYRPA_PLAF7/39-353        AC Q8IFM8.1
#=GS A0A1J1GJW4_PLARL/33-341   AC A0A1J1GJW4.1
#=GS A0A0L1I3X9_PLAFA/33-203   AC A0A0L1I3X9.1
#=GS A0A509ANV7_PLABA/33-342   AC A0A509ANV7.1
#=GS A0A1Y1JET1_PLAGO/34-354   AC A0A1Y1JET1.1
#=GS W7K011_PLAFO/33-344       AC W7K011.1
#=GS A0A024WVI4_PLAFA/33-344   AC A0A024WVI4.1
#=GS A5K678_PLAVS/37-357       AC A5K678.1
#=GS A0A384L9X5_PLAKH/36-357   AC A0A384L9X5.1
#=GS A0A024XE54_PLAFC/203-320  AC A0A024XE54.1
#=GS A0A024WWH3_PLAFA/1-158    AC A0A024WWH3.1
#=GS A0A0L7K5U6_PLAFX/154-297  AC A0A0L7K5U6.1
#=GS A0A0L7M503_PLAF4/190-333  AC A0A0L7M503.1
#=GS A5K9M0_PLAVS/33-342       AC A5K9M0.1
#=GS A0A1Y1JFX6_PLAGO/33-342   AC A0A1Y1JFX6.1
#=GS A0A1A8WSA4_9APIC/106-422  AC A0A1A8WSA4.1
#=GS W7JTZ7_PLAFA/1-302        AC W7JTZ7.1
#=GS Q7RKT0_PLAYO/33-342       AC Q7RKT0.1
#=GS A0A1D3JLR6_PLAMA/33-349   AC A0A1D3JLR6.1
#=GS K6UTD1_PLACD/34-350       AC K6UTD1.1
#=GS K6UU69_PLACD/101-194      AC K6UU69.1
#=GS A0A1A8YXP2_9APIC/33-341   AC A0A1A8YXP2.1
#=GS A0A024VVV9_PLAFA/26-174   AC A0A024VVV9.1
#=GS A0A0L7KAJ3_PLAFX/39-104   AC A0A0L7KAJ3.1
#=GS A0A1J1H6J2_PLARL/34-338   AC A0A1J1H6J2.1
#=GS A0A5K1K8W5_PLAF7/33-344   AC A0A5K1K8W5.1
#=GS A0A1A8VYQ0_9APIC/33-342   AC A0A1A8VYQ0.1
#=GS A0A024XDH0_PLAFC/39-353   AC A0A024XDH0.1
#=GS A0A024XE54_PLAFC/33-205   AC A0A024XE54.1
#=GS A0A0L7K5T2_PLAFX/33-203   AC A0A0L7K5T2.1
#=GS A0A024VU91_PLAFA/39-223   AC A0A024VU91.1
#=GS A0A024VWN6_PLAFA/33-344   AC A0A024VWN6.1
#=GS A0A0L7KAJ3_PLAFX/101-317  AC A0A0L7KAJ3.1
#=GS A0A024VT16_PLAFA/33-344   AC A0A024VT16.1
#=GS A0A384LLL0_PLAKH/33-342   AC A0A384LLL0.1
#=GS A0A0L0CZA7_PLAFA/33-203   AC A0A0L0CZA7.1
#=GS A0A1D3U8Q3_9APIC/33-342   AC A0A1D3U8Q3.1
#=GS A0A653H850_9APIC/35-355   AC A0A653H850.1
#=GS A0A0L7M9Q9_PLAF4/13-67    AC A0A0L7M9Q9.1
#=GS A0A1A9AKZ2_9APIC/34-350   AC A0A1A9AKZ2.1
#=GS W4J745_PLAFP/39-353       AC W4J745.1
#=GS W7K0G8_PLAFO/39-353       AC W7K0G8.1
#=GS W4IVY7_PLAFP/33-344       AC W4IVY7.1
#=GS A0A1J1H6H7_PLARL/32-341   AC A0A1J1H6H7.1
#=GS A0A1A8W5D8_PLAMA/34-344   AC A0A1A8W5D8.1
#=GS A0A653HNM2_9APIC/33-342   AC A0A653HNM2.1
#=GS A0A024WCP8_PLAFA/1-302    AC A0A024WCP8.1
#=GS W7JGV1_PLAFA/33-344       AC W7JGV1.1
A0A024WX65_PLAFA/4-152               ...vqkgl-----------------------------.----.---------------..--------------------------.-------.....------.-----------.-------.------.---------------------------------------.--------------------.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
A0A0L7M5R2_PLAF4/33-203              .liknahs-------DICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.-----------------------------------------------------......--..--------.-------------------------.-------------------------.--------------------------------.................
A0A0L1IAB9_PLAFA/39-353              ........LSFIKNNVPCIRDMFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGRPHIFAYVDVE.EIIILLC.....EDEEFSnRKKDMTCHRFY.SNDGKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
K6UU69_PLACD/1-104                   ........------MKKCYLEHFVNFKGEIVQVCLDK.VSST.SVNKYNILISSYGEDkkWKMQNKVLSSYTIKILRYFYSFTNGE.ELVVVFC.....FNKNLS.-IQPYECFRSV.SDDLKTL.KTEK--.---------------------------------------.--------------------.-----------------------------------------------------......--..--------.-------------------------.-------------------------.--------------------------------.................
CYRPA_PLAF7/39-353                   ........LSFIKNNVPCIRDMFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGRPHIFAYVDVE.EIIILLC.....EDEEFSnRKKDMTCHRFY.SNDGKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
A0A1J1GJW4_PLARL/33-341              ......yv---VNSPIFCIRESFMYFRNEVYRVCVNS.NEDE.DFNIHIYVQKRKGNS..WEIEDELLKGKKKKSFISFFSYVYDE.EIIIILC.....DFEGYG.KNKKINCFRSH.SSTGVDF.TTENIN.VPHDIFNNKDLSYYSSFPYEFNGEKYLLICGIINYIFKS.Y-EGDFIGCAASSDKGSTWN.TKFHFRYDGTKHFTSYFLLKVKIFNNKLAFFFHYASTSE---ESGKYIECSNK......SN..NDFYCEDV.HFDKE-KSLRSVIKLNDYFITSFVN.KNDRKACYLYYTNENSFLIKPKNTG.DELSGCYRASFIKIHDNKIMFVHLSGYGVYNI.................
A0A0L1I3X9_PLAFA/33-203              .liknahs-------DICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.-----------------------------------------------------......--..--------.-------------------------.-------------------------.--------------------------------.................
A0A509ANV7_PLABA/33-342              ........ISKDSNIRKCHKEHYLNFQGQIVQVCNDK.IITN.TSMSNNIYISVYNKEnkWEDKLKLFNNHTQKKIEYFYSFISND.SLVIIYC.....FSKSLI.-SSPYECHSAT.STDLITF.TTQKIG.IDFKSIDPLSLQDYSINELDIFEKKYILICGLDIQKKQY.GEYNKFILCNASSNGGINWT.EKFTFFVTGVDPKLKYTKLVPKINGNEIGFLYYSEKEHLNR-----YLKCKYR......DG..YDYECYLV.GLARLESYMWDISKIRGYYISIIS-.NNKQPPHYIYYMHTNIYTIPLEAPT.SMDVDYKKGNLFPLDSYRLIYNYVAGNNTYTY.................
A0A1Y1JET1_PLAGO/34-354              ........IKTIKSPIHCILAVYFVLRNELYKTCVQH.ITKK.QSEIHVIVQKNVEDT..WKTQEKLFSDLSWVEVPSIFNFINKD.EAVIIIC.....KYKDKS.KEDGAICERWS.TSTGENY.TKEDVA.IDKEVFNNKNIESYTSHPLKISNKEYFLICGVRYFDYEN.DSIDNFISCSASEDKGRKWT.TKILINYKQYKSRMPHSYVKPVVLNDEFGLYFYSRRSTSHSSREYKYMKCTKDekhtndNE..YKFNCSDV.NVTRSNKILQNITKLNGHYLTNYIL.RDNFKECYLYYSDENAIVIKPKIQN.YNLSGCYEGSFINLNESKSLFIYSTGYGVQNI.................
W7K011_PLAFO/33-344                  liknahsd--------ICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.LTFSFYYPHAKSSVLYSKVVPKISYNEIGFLFFSPDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
A0A024WVI4_PLAFA/33-344              liknahsd--------ICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.LTFYFYYPHAKSSVLYSKVVPKISYNEIGFLFFSTDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
A5K678_PLAVS/37-357                  ........ITTIKSPIHCITDIYFLFRNELYKTCIQH.VIKG.RTEIHVLVQKKINST..WETQTTLFKDHMWFELPSVFNFIHND.EIIIVIC.....RYKQRS.KREGTICKRWN.SVTGTIY.QKEDVQ.IDKEAFANKNLESYQSVPLTVKNKKFLLICGILSYEYKT.ANKDNFISCVASEDKGRTWG.TKILINYEELQKGVPYFYLRPIIFGDEFGFYFYSRISTNNTARGGNYMTCTLDvtnegkKE..YKFKCKHV.SLIKPDKSLQNVTKLNGYYITSYVK.KDNFNECYLYYTEQNAIVVKPKVQN.DDLNGCYGGSFVKLDESKALFIYSTGYGVQNI.................
A0A384L9X5_PLAKH/36-357              ........ITTITSPVHCIADTYFIFRNELYKICIQH.VNKG.RTEIHVIVQKKAKNK..WETKQKLFEDKMWFHLPFVFNFVQND.EIIILVC.....RYKGMT.KGEGVACDRWS.STTGTNY.NKGNIN.IDAQALTKMNLDSYASFPIPIKDKAIIHICGVHSYEYQN.VNQNNFISCLASEDKGTTWGdIKIHIYYDQFQEGVPYFYLRPLVFNDEFGFYLYSRISSNNADRGGKYMKCILNptnsrnKE..YTFKCTNV.NLIKEDKSLQNITKLNGYYVTSYAK.KNNFNECYLYYTENNAIVVKPKVQN.YELNGCYGGSFVKFNESKALFIYSTGHGVQNI.................
A0A024XE54_PLAFC/203-320             ......gy-----------------------------.----.---------------..--------------------------.-------.....------.-----------.-------.------.---------------------------------------.--------------------.-------------------------NEIGFLFFSPDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
A0A024WWH3_PLAFA/1-158               ........-------------MFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGRPHIFAYVDVE.EIIILLC.....EDEEFSnRKKDMTCHRFY.SNDGKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.-----------------------------------------------------......--..--------.-------------------------.-------------------------.--------------------------------.................
A0A0L7K5U6_PLAFX/154-297             ...strlt-----------------------------.----.---------------..--------------------------.-------.....------.-----------.-------.------.---------------------------------------.--------------------.--FSFYYPHAKSSVLYSKVVPKISYNEIGFLFFSPDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
A0A0L7M503_PLAF4/190-333             ...strlt-----------------------------.----.---------------..--------------------------.-------.....------.-----------.-------.------.---------------------------------------.--------------------.--FSFYYPHAKSSVLYSKVVPKISYNEIGFLFFSPDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
A5K9M0_PLAVS/33-342                  ........ISKDTNMKRCFLEHFVNFKGEVVQVCLDQ.IPSR.VVNQYNILISSYGEDkqWRMQSKVLSGHTTKLLRYFYSFTNGQ.QLVVVFC.....FNKNLS.-KPPYECFRSI.TDDLKTL.KTEKIQ.IDLRMFEPSSFSDYALSSFDLFGVGNLLICGVNNKRNAK.PNVGLLVICHASADGGLTWG.KRLHFYHPNMDKHTTYESLVPKISGNEIGFQYLASKVSLTK-----YFKCAYK......KD..HDFECQDV.NLVREQSYIWDIAKVRGYYVAPLS-.DGKVPPCTIYYMYNNTYLMPLEVPK.SVGAEYHRGNLFPLDNKRLVYNYVNEKETYTY.................
A0A1Y1JFX6_PLAGO/33-342              ........ISKNTNMRVCHLEHFVNFKNEIVHVCLDK.VETT.SMKKHNIIISSYGEDkkWKERSKALTSYTTKLLAYFYTFTNNN.QLVVVFC.....FNKTFS.-KSPYECFRTI.TDDLNTV.KTEKIQ.IDLRMFEPSSFSDYALNSFDIFGIPHLLICGVNNKRNSG.KNFGLFVICHASPDGGFSWG.RRLHFYHPNMEKHTVYEKLVPKVSGNEIGFQYLSPKISLTK-----YLKCTYR......KD..YQFECHDV.NLVREQSYMWDIAKVKGYYVAPLS-.DGKSPPCTLYYMYNDTYMIPLETPR.SIGSEYHRGKLFHLDSERLIYNYENEKETYTY.................
A0A1A8WSA4_9APIC/106-422             ........ISTVTDEKYCTQDSYFLFHDELYKICIQH.LIKN.DIEISIYVQKEVKNS..WETQEELISDVNTKKPFSLHTYIDDN.EIVIIMC.....KCVNDL.SIDRNECYRWD.STNGNFF.KKEDIT.IPDSAFNKRRMTSYTLYPLTISTKKILLLCGINIDPYVP.QKKEEFIYCIGSENRGKTWM.RKVQIIYEGFQPNGIYYHLTPHIFNDELGFHFYSLVGANNTGVGGEYIVCKPE......KGmlYRMKCENA.NLGKEGKSLQDLTKMNGYYIASYVN.KEKSNECYLYYTSENAIILNPKKQG.YLMNGCYSGFFVKINESSTLFIYAPDYGTYNI.................
W7JTZ7_PLAFA/1-302                   ........-------------MFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGRPHIFAYVDVE.EIIILLC.....EDEEFSnRKKDMTCHRFY.SNDGKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
Q7RKT0_PLAYO/33-342                  ........ISKDSNIRKCYKEHYLNFQGQIVQVCNDK.IVTN.TSISNNIYISAYNTEnkWEEKLKLFNDHTKRKIEYFYSFINNE.NLVIVYC.....FSKSLN.-YSPYECHNAI.STDLITF.TTQKIN.IDFKSIDPLSLQDYSISELDIFEKKYILICGLDTQRTQY.GEYNKFILCNASSDGGINWT.EKFTFFVTGVDPKLKYTKLVPKINGNEIGFLYYSEIESLNR-----YLKCKYK......DG..YDYECYLV.GLARLESYMWDISKIRGYYISIIS-.NNKQPPHYIYYMHTNIYTIPLEAPT.STDVDYQKGNLFPLDSYRLIYNYVAGKNSYTY.................
A0A1D3JLR6_PLAMA/33-349              ......ts--SLNNTTQCSQDVHFAFKKELYKYCVEH.DIK-.NTESHVYIQKKENNR..WISQSELLGKFYKIKPVSIFNFVDDN.QIILIIC.....EYINND.KTNTKDCYRWS.SQDGTTF.TKENVV.IDNDIFNNKNYSSYSSAPLKISNKTYLLICGTHSNQLKNnKNEDHLASCTASDDDGRNWR.TQIKINYSGFQADSPFFALTPHIFNDELGFYFYTGVNISTKSTGGQYIACSVDn....gTN..ISFNCNDV.NLFKENKLLQNITKLSDHYLTNYID.KDYLDLCYLYYTKENAIMIGSPKHI.YNDHKCYNSSIIKEDESTFFFTYYKGHGLQNM.................
K6UTD1_PLACD/34-350                  ........IKTIKSPIHCINEIYFLFQDELYKTCIQH.VIRG.RTEIHVLIQKQINST..WETQAKLFEDKLWFHVPSVFNFVLDD.EIIIVIC.....RYKSVN.KKEGATCERWK.SVTGTTY.KKESLQ.IGE-TFANKNIDSYASVPLKISKKKFLLICGIHSYEYQD.SNKDNFISCIASEDKGATWR.TQIHINYEQFKKGIPYFYLRPLIFDDEFGFYFFSRISTINTGRGGNYMTCTPEa....tNE..YKFICKDVnNLIKENKSLQNITKLSGYYITSYVK.KDNFNECYLYYTEHNAIVVKPKVQN.YDLNGCYGGSFVKLDEEDALFIYSTGHGVQNI.................
K6UU69_PLACD/101-194                 ......kt-----------------------------.----.---------------..--------------------------.-------.....------.-----------.-------.------.---------------------------------------.--------------------.----------------------------------------------------E......KD..HDFECHDV.NLVREQSYIWDIAKLRGYYIAPLS-.DGKAPPCTLYYMYNNTYLMPIEVPK.SIGKEYHRGKLFQLDSKRLIYNYTNEKETYTY.................
A0A1A8YXP2_9APIC/33-341              ........ISKDTNIRKCYQEHYLNFNGEIVQVCLDK.IPTN.TVTLYNIIVSSYGDEkkWVEKYKLISKNTMKIMKYFYSFVSNDdKLTIIFC.....FNKVVT.-KAPYECHYSS.TKDLKDV.KTDKIK.VDFGIFDPLALEDYSLPNLELFEKKFLLLCGLNGRRNSS.GGPHPFVICHGSIDGGVNWN.HKLLFHLADMKKNVAYRKLVPKIGGNEIGFRYFDPSVSLTK-----YIKCAYM......KE..NNFECKEV.ILAREEDYIWDLTKIRGYYVAILS-.KGYKPPCSLYYMYNNVYLMPLEVPQ.SIGVKYDRGEDFY-------------------lrlklnyknnfviqnda
A0A024VVV9_PLAFA/26-174              ....rrak-----------------------------.----.---------------..--------------------------.-------.....------.-----------.-------.------.---------------------------------------.-------------------T.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
A0A0L7KAJ3_PLAFX/39-104              ........LSFIKNNVPCIRDMFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGL----------.-------.....------.-----------.-------.------.---------------------------------------.--------------------.-----------------------------------------------------......--..--------.-------------------------.-------------------------.--------------------------------mm...............
A0A1J1H6J2_PLARL/34-338              .......y--TIKHNDQCKKQQYVYFLKKMYKLCYLW.YDMD.DSYQKILVQTIKNDK..WEIKSELIYNKETTNYLY-YSYVINE.KLIVVNC.....FSNS--.RLQKYECIRSV.SNDGIHF.ENMSTS.FSMIPHDISSINDYSSQPFYFKEKNYLLICSLNGNISWD.KKPKLFITCTASSDNGVNWG.TIFRFYYVS--PDFNYNRLKPVINGRSIGFHFTKYKN---NIWARDYIECNYN......TD..FDFECNPI.DLQKDKKNLQAVLKIDNNYVSSYMG.KDDFL-CYLYYTSENIILIKTEIKR.NKRGDCNPRDLIMLDNLKFVLIYADGMNI---dgf..............
A0A5K1K8W5_PLAF7/33-344              liknahsd--------ICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.LTFSFYYPHAKSSVLYSKVVPKISYNEIGFLFFSPDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
A0A1A8VYQ0_9APIC/33-342              ........ISKDTNIRKCYQEHYLNFNGEIVQVCLDK.IPTN.SVTLYNIILSSYGDDkkWVEKYKLISKNTMKIMKYFYSFVSND.MLIIIFC.....FNKVVT.-KAPYECHYTS.TKDLKDV.KTDKIK.VDFGIFDPLALEDYSLPDLELFDKKFLLLCGLNGRRNSS.GGPHPFVICHGSIDGGVNWS.HKLLFHLPDMKKHVAYRKVVPKIGGNEIGFRYFDPSVSLTK-----YIKCAYM......KE..NNFECKEV.ILAREEEYIWDLTKIRGYYVAILS-.KGYKPPCSLYYMYNNVYLMPLEVPQ.SIGDKYDRGNLFPLDSSRVIYNYVNEKTTYTY.................
A0A024XDH0_PLAFC/39-353              ........LSFIKNNVPCIRDMFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGRPHIFAYVDVE.EIIILLC.....EDEEFSnRKKDMTCHRFY.SNDGKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
A0A024XE54_PLAFC/33-205              .liknahs-------DICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.-----------------------------------------------------......--..--------.-------------------------.-------------------------.--------------------------------yn...............
A0A0L7K5T2_PLAFX/33-203              ..liknah------SNICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.-----------------------------------------------------......--..--------.-------------------------.-------------------------.--------------------------------.................
A0A024VU91_PLAFA/39-223              ........LSFIKNNVPCIRDMFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGRPHIFAYVDVE.EIIILLC.....EDEEFSnRKKDMTCHRFY.SNDGKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.IYVM-------------------------------------------------......--..--------.-------------------------.-------------------------.--------------------------------cinnidhidh.......
A0A024VWN6_PLAFA/33-344              liknahsd--------ICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLNEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.LTFSFYYPHAKSSVLYSKVVPKISYNEIGFLFFSPDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
A0A0L7KAJ3_PLAFX/101-317             ....glmm-----------------------------.----.---------------..--------------------------.-------.....------.-----------.---GKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
A0A024VT16_PLAFA/33-344              .liknahs-------NICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.LTFSFYYPHAKSSVLYSKVVPKISYNEIGFLFFSPDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
A0A384LLL0_PLAKH/33-342              ........ISKDTNMKQCYSEHFVNFKGEIVQVCLDK.VPYG.SLNKYNILISSYGEDkkWTMQSKALDNYTTKLLKYFYSFTNNE.QLVVVFC.....FNKNLS.-NPPYECYRSI.TNDLKTL.KTEKIQ.IDLRMFEPSSFNDYALNSFDLFGVGHFLICGINNKRNSK.PNVGLLVICHASADGGFTWK.KKLNFYHPNMDKNTTYESLVPKISGNEIGFQYLASKVSLTK-----YFKCYYK......KD..HDFECQDV.NMVREQSYIWDIAKIRGYYVSPIS-.DGKAPPTQLYYMYKNTYLMPIEVPK.SIGTEYNRGKVFQLDNQKLIYSYANEKEAYTY.................
A0A0L0CZA7_PLAFA/33-203              .liknahs-------DICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.-----------------------------------------------------......--..--------.-------------------------.-------------------------.--------------------------------.................
A0A1D3U8Q3_9APIC/33-342              ........ISKDTNIRKCYQEHYLNFNGEIVQVCLDK.IPTN.SVTLYNIILSSYGDDkkWVEKYKLISKNTMKIMKYFYSFVSND.MLIIIFC.....FNKVVT.-KAPYECHYTS.TKDLKDV.KTDKIK.VDFGIFDPLALEDYSLPDLELFDKKFLLLCGLNGRRNSS.GGPHPFVICHGSIDGGVNWS.HKLLFHLPDMKKHVAYRKVVPKIGGNEIGFRYFDPSVSLTK-----YIKCAYM......KE..NNFECKEV.ILAREEEYIWDLTKIRGYYVAILS-.KGYKPPCSLYYMYNNVYLMPLEVPQ.SIGDKYDRGNLFPLDSSRVIYNYVNEKTTYTY.................
A0A653H850_9APIC/35-355              ........ITTAYSDIECSKDIYFIFVRQLYKACFKT.TKEK.DVANDIFIQKKENNV..WVTTEQLKTEKTYKDILSFHIFVDIY.QVLIIECllenqENDNNT.GQQPYQCFRWS.SKTGSSY.NSKTINnIPFDFLNNNNIFYYATEPILIRDQPILLVCGFNNNSKQT.DQTDKFVSCIASLDEGENWK.EEMSVIYKNMDPQSTYYSLAAHVYQNILGFYFYTPVDVNDETQGGNYIECEYS......EP..NTFNCEKL.ELSKNGRTLIDITKLSGHYIGGYAN.VNNPTECYIYYTDKNAIILHSPQKT.YNMIGCYRGMFAKIDERNALFIYLSSNQVYNI.................
A0A0L7M9Q9_PLAF4/13-67               ..islsvi-----------------------------.----.---------------..--------------------------.-------.....------.-----------.-------.------.---------------------------------------.--------------------.-----------------------------------------------------......--..--------.-------------------------.--------FFLTMKILYLIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
A0A1A9AKZ2_9APIC/34-350              ........ISTVTDEKYCMQDSYFLFHDELYKICIQH.MIKN.DIEINIYVQKEVNSS..WETQEELISDVNTKRPYSLHTYIDDN.EIVIIMC.....KYINDL.SINRNECYRWH.STNGNFF.EKEHIK.IPDSAFNKRRMTSYTLSPLTMSTKKILLLCGINIDPYVP.QKKEEFIYCIGSEDRGKTWI.RKIQIIYEGFQPNGIYYQLTPHIFNDELGFYFYSLVGANNTGAGGEYIFCKPE......KGilYRMKCENA.NLGKEGKSLQDLTKMNGYYIASYVN.KEKSNECYLYYTNENAIILNPKKQG.YLMNGCYSGFFVKINESSTLFIYAPDYGP---sti..............
W4J745_PLAFP/39-353                  ........LSFIKNNVPCIRDMFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGRPHIFAYVDVE.EIIILLC.....EDEEFSnRKKDMTCHRFY.SNDGKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
W7K0G8_PLAFO/39-353                  ........LSFIKNNVPCIRDMFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGRPHIFAYVDVE.EIIILLC.....EDEEFSnRKKDMTCHRFY.SNDGKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
W4IVY7_PLAFP/33-344                  liknahsd--------ICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.LTFSFYYPHAKSSVLYSKVVPKISYNEIGFLFFSPDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
A0A1J1H6H7_PLARL/32-341              ...ilkrv-----EETTCFRQHYVSFKNQLLKVCLYY.KSTEyPKYTFNIYIYKVNEEdkWEKKNELIIGNTNRNIRYFYTFSTED.KIIVVFC.....YNMNLY.-RTPCKCFYST.SYDGITF.ETKRTA.LNYIVFNYLSVTDYYSKHYDLFGENFLLMCGINH-QIIH.DNSKNLIVCFGSNNDGKSWD.YKFNFRYLKANINISYFMLKLIISGNEIGFKYVTSEAPFSA----TYIKCKYK......SM..HDFYCDDV.DLKIGDKIIRDIVKVGGYYLTSQS-.DTNLSTCQLYYVY-NSVVLAPANGK.SEGYKCHKDNFFPLENSRLIYSFENENLSY--sy...............
A0A1A8W5D8_PLAMA/34-344              .......l-SENSNIQKCYLEHYVNFKGQIVQVCLDQ.ITSS.SVTRYNIFINAFNEKrkWERKLKIIDNHTRKMTRYFYSFISND.ELIVIYC.....FNKNLT.-QPPYECHRIT.TNDMQTIkNKEKIN.LDFKVFETSSLTDYSSDNLQIDDHNYILICGVNNKRNSHgKNTKMFVLCQASSDNGVSWR.L-FNFQYTNVSSSWSYQRIVPKISGNEIGFKYFSPNISLSK-----YIKCRYK......KE..NDFECTDV.DLVRSNSYMWDIVKVKGYYVSILS-.NSKKPPCYLYYMYNNTYLIPLEAPK.SIGNTYNRGNLFQLDNSRVVYNYMNENGSYTY.................
A0A653HNM2_9APIC/33-342              ........ISDNENFKQCHKEHYLSFKGYITQVCLDKkVENE.KKTSYNIIINYLSGKkiWIESSQVLDEYTEKEIKYFYSFKNND.KIVVIYC.....LSEKKN.-AIPNECYTSI.YDELNHV.ITKPIN.IELETMDLESLTNYSTNELKLGDRTFILICGITSKKDLK.NN--FYVVCHGSNDEGITWE.YQFLLSVPKVNSDIMYHHIILKVTEIEVGFLLEDTNT-----KLKMYMRCIYF......KE..YQYECYHM.NFVRKNSYIYDLLKFKGYYLGILNN.MEKTLPSMIYYMNKNTFLIPREIPK.IEDPQYKEGNLYQLDNERVIYNYKKGSDKFT-y................
A0A024WCP8_PLAFA/1-302               ........-------------MFFIYKRELYNICLDD.LKGE.EDETHIYVQKKVKDS..WITLNDLFKETDLTGRPHIFAYVDVE.EIIILLC.....EDEEFSnRKKDMTCHRFY.SNDGKEY.NNSEIT.ISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKD.DNKKDDILCMASHDKGETWG.TKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGD-NINNVKNVNFIECTHE......KD..LEFVCSNR.DFLKDNKVLQDVSTLNDEYIVSYGN.DNNFAECYIFFNNENSILIKPEKYG.NTTAGCYGGTFVKIDENRTLFIYSSSQGIYNI.................
W7JGV1_PLAFA/33-344                  liknahsd--------ICKREHYISFNKEIIKLCLFS.QPSG.VHSKYNLIVNTLKEE.kWEEKYKILKENTFKILKYFYTFVNKN.ELVIIFC.....FNKLIN.-KAPYECHRSInKVDGKGN.EEQRVR.INYNHIDPLSLVDYTSNTFDFLGTSYLLICGINENRKLS.PGSHVFILCRASKDSGITWG.LTFSFYYPHAKSSVLYSKVVPKISYNEIGFLFFSPDVSINK-----YIKCTYR......EG..NHFDCDDI.HFI-DDKYLLDITKVRGYYLTILSNkKDKKEKVKLWYIYNSVISESMRNNAiSSGNEYREGNLFLLNDSTVLYNYLNEKDSY--ly...............
#=GC seq_cons                        .................Chp-hah.FppElhplCL.p...st..pppa.hl.pphp-p..W.pp.clhpcpshphh.ahasalstp.cllIlhC......sc.hs..ptshpCaR.h.psDGpth.pppclp.Is..hhcshtLssYso.shch.sppahLICGls..+h.s.sspc.hIlChASpDpG.oWs.hph.hhasphp.ts.Y.hlhPhI..N-luFhaassp.s.sp.....alcCpac......cs...cF.Cpsh.phhh-pchl.DloKlps.Yls.hu..csph..shlaYh.psshhht.c..t.spssthhtGshhhlspspsla.Y.spps.Y...................
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