#=GF ID   Cytomega_gL
#=GF AC   PF01801.20
#=GF DE   Cytomegalovirus glycoprotein L 
#=GF PI   Cytomegalo_gL; 
#=GF AU   Bashton M;0000-0002-6847-1525
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1420 (release 4.2)
#=GF GA   25.00 25.00;
#=GF TC   46.90 44.30;
#=GF NC   22.90 21.60;
#=GF BM   hmmbuild  --aminoHMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10196283
#=GF RT   Intracellular formation and processing of the heterotrimeric
#=GF RT   gH-gL-gO (gCIII) glycoprotein envelope complex of human
#=GF RT   cytomegalovirus. 
#=GF RA   Huber MT, Compton T; 
#=GF RL   J Virol 1999;73:3886-3892.
#=GF RN   [2]
#=GF RM   7964634
#=GF RT   Identification, sequencing and expression of the glycoprotein L
#=GF RT   gene of murine cytomegalovirus. 
#=GF RA   Xu J, Scalzo AA, Lyons PA, Farrell HE, Rawlinson WD, Shellam GR; 
#=GF RL   J Gen Virol 1994;75:3235-3240.
#=GF DR   INTERPRO; IPR002689;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Glycoprotein L from cytomegalovirus serves a chaperone for the
#=GF CC   correct folding and surface expression of glycoprotein H  (gH)
#=GF CC   [2]. Glycoprotein L is a member of the heterotrimeric gCIII
#=GF CC   complex of  glycoprotein which also includes gH and gO and has
#=GF CC   an essential  role in viral fusion [1].
#=GF SQ   27
#=GS Q8QRZ3_9BETA/31-264      AC Q8QRZ3.1
#=GS A0A075CYB5_9BETA/26-245  AC A0A075CYB5.1
#=GS G8XT12_9BETA/17-236      AC G8XT12.1
#=GS M1RA16_ELHV1/65-278      AC M1RA16.1
#=GS GL_HHV6Z/33-249          AC P52526.1
#=GS GL_HHV6U/33-249          AC P52508.1
#=GS Q7TFJ4_RHCM6/23-244      AC Q7TFJ4.1
#=GS A0A0F7GB68_SCMVC/21-243  AC A0A0F7GB68.1
#=GS A0A0S1TR08_9BETA/35-260  AC A0A0S1TR08.1
#=GS U6HC64_9BETA/38-250      AC U6HC64.1
#=GS M4JZ51_ELHV1/24-243      AC M4JZ51.1
#=GS A0A1P8VIY7_9BETA/36-247  AC A0A1P8VIY7.1
#=GS GL_MUHVS/52-264          AC P52514.1
#=GS GL_HCMVA/45-268          AC P16832.2
#=GS G8XUH3_9BETA/16-238      AC G8XUH3.1
#=GS A0A1L6Z0F1_9BETA/23-244  AC A0A1L6Z0F1.1
#=GS A0A0K1H0F4_9BETA/23-244  AC A0A0K1H0F4.1
#=GS G8XU04_SCMVC/22-243      AC G8XU04.1
#=GS K7XWE4_RCMVE/50-261      AC K7XWE4.1
#=GS H2A2D9_MUHV1/52-264      AC H2A2D9.1
#=GS GL_HCMVM/45-268          AC F5HCH8.1
#=GS Q9DW84_RCMVM/98-309      AC Q9DW84.1
#=GS I3VQA5_9BETA/23-239      AC I3VQA5.1
#=GS GL_HHV7J/30-245          AC P52509.1
#=GS Q91TI6_TUHV1/104-323     AC Q91TI6.1
#=GS A0A191S3V8_9BETA/31-249  AC A0A191S3V8.1
#=GS I3WEZ6_9BETA/23-244      AC I3WEZ6.1
Q8QRZ3_9BETA/31-264                 .....................dp-ACPELTRRCLA.GE.VFPakdd..swlwPLVNathrdgmLSQL...I...RYP...SLRHQQ...QLLQG.QQQ.QAVGA..VTVDDGFLESLLMLYNNPSQLRALLTLINSDAAPR.WMALL.............RG.............YGQCG.DGSPSIYTC..V..D..DL....C...R..G.YDLTQLKYVRTVFSEHVLG..FELV..PPF.yFNA.............L..L..AVRN..EATRTSRAVRVPVSTarspggITLFYQLYNLVKEFCLRH.G..L.NPPLLQRLDKYYADLPAALK.QARVNLPAR-s.................
A0A075CYB5_9BETA/26-245             .....................sl--CYNNTVNCLK.GE.N--..........--IS.......FQGI...P...KYS...SNYSKL...IRYRY.DSE.VATNA.mYPIDTKVQEVLSLFYQNSEDLRVFLSL-RMDTKST.WEKTL.............SGasglrtekeeettYTFC-.DGTYKYFYC..SphS..KD....Cs.gS..K.VDLTSIDYVNSIFSENVAE..ISFK.gKPS..LEV.............L..VklFIYN..NITSKYRVVTIPLRT......PALLDVLFNATYRMLYRD.K..S.SHALLKAFKLFFAR------.----------yigepyrgpr........
G8XT12_9BETA/17-236                 ......................e-TCVTLVRQCVA.GDsVLN..........GTQNg.....tSEPL...V...KPPsddAMLSQL...IRYNH.SGI.TTITS.kIPIDDTFIDHLALLHNNTKQLRILLAILRSDTAPA.WMKAM.............SG.............YGVC-.GQEAAIYTC..Y..A..DV....C...R..A.YDLTKLTYVNTIFTENVLG..FELL..PHF.kFAV.............L..L..GARN..EDSKMGRPIRIPIPKt....gIGLFYAIWNVIKGFFTQN.E..L.QSPLIARLEKYYQDLDAEYK.----------llpkknvlff........
M1RA16_ELHV1/65-278                 .....................ps--CYNSTLTCLN.GG.NL-..........--S-.......FPGM...P...QYS...SNYSKL...IRYGY.GPN.IRTSE..YPIDQKVYDALSLFYRNEEDMRVFLSLRKDSN-GT.WEKGL.............IGvpelktvqederkYVFCD.KVYA-TFYCspY..T..KN....C...NngK.RNLNELPYVDSIFTEHVVEivFHGS..PTL.kIEV.............K..I..LLYN..PVTLEHRIVTIPLFT......PALLDATFNILYRTLYRD.P..T.SHALLKTFKNFFD-------.----------qnieep............
GL_HHV6Z/33-249                     .......................DDCIAAVINCTR.SE.V--..........PLL-.......LEPI...Y...QPP...VYNEDVm.sILLKP.PTK.KKPFS.rIMVTNEFLSDFLLLQDNPEQLRTLFALIGDPESRDnWLNFF.............NG.............FQTC-.SPSVGITTC..I..S..DN....C...R..K.YLPERITYVNNFFVDNIAG..LE--..---..FNIsentdsfysnigfL..L..YLEN..PATGITKIIRFPFNS......LTLFDTILNCLKYFHLKT.G..V.EFDLLKQMEAYNSKLP--FR.SSRPTILIRN..................
GL_HHV6U/33-249                     .......................DDCIAAVINCTK.SE.V--..........PLL-.......LEPI...Y...QPP...AYNEDVm.sILLQP.PTK.KKPFS.rIMVTDEFLSDFLLLQDNPEQLRTLFALIRDPESRDnWLNFF.............NG.............FQTC-.SPSVGITTC..I..R..DN....C...R..K.YSPEKITYVNNFFVDNIAG..LE--..---..FNIsentdsfysnigfL..L..YLEN..PAKGVTKIIRFPFNS......LTLFDTILNCLKYFHLKT.G..V.ELDLLKHMETYNSKLP--FR.SSRPTILIRN..................
Q7TFJ4_RHCM6/23-244                 .....................nl-TCLELTRRCFT.GE.TFS..........PEDDs.....wAKPLikvN...HPD...GNLSQL...LRYTP.LTK.HAAST..IPLDDTFMDFVALLHNNPAQLRTLLTLLKSDGAPT.WMKIM.............QG.............YSECG.DT-GSIYTC..V..D..NV....C...R..A.YDLRYLTYSNSIFTENVLG..FDFG..HKG.qFAA.............L..V..VVRH..EDIKMHRPVRIPVATradrngLQLFYALYNLVRELLVRH.D..L.DTALIDRLDKYYLDIPDEWK.Q---------pltnnpal..........
A0A0F7GB68_SCMVC/21-243             .....................nf-TCLELTRRCFI.GE.TFP..........PEDEs.....wTKPLvhvN...HPD...GNLSQL...LRFTA.STK.HASPL..ISLDDNFMDYLTLLHNNPQQLRVLLALLKSDAAPV.WMTLM.............QG.............YSECG.DTG-PIYTC..I..D..NV....C...R..A.YDLRQLTYQRSIFTEHVLG..FEFG..DEG.qFSI.............I..L..ALRN..LDSKVHRPIRIPVSTkaqkdgLPLFFAIYNYLKEFFIRH.D..L.ETALIDRLDKYYHDLSDEWK.Q---------plsnnpall.........
A0A0S1TR08_9BETA/35-260             dscllelsmclkghsyvfsqhty------------.--.---..........----.......----...-...--T...NAYSNM...IRYDY.ESK.TSRVM..APLTNTSHDFILLVYNNTEELRVFLTL-RHDSGSA.WERNL.............VGlnreyvpdddnphYKAC-.DGKRSIFVC..S..Q..NNhhrvCgkdR..K.VNLLGLNYKNSIFTERVVS..ITAY..RHP..FKI.............VvrV..LLTN..EATDSYRVASIPFHT......PALLDVLFSSIYRRVYRH.R..E.GLRILHTFKRFY--------.----------vqsvdehfrgprnrvfek
U6HC64_9BETA/38-250                 ......................t-ACTVAAISCAN.SD.TYNr........tTVSN.......HTFF...Y..iSDR...WKYSEL...IRYEK.PTW.DLRHDklIHVDREFLDIVSLLHNNENQLRTLLTIFRSDSAPP.WVKFM.............RG.............YSQC-.LDHPIIYTC..V..E..EK....C...Q..Q.YNLEELPYGKDIFLENVVG..FDLG.aPPH.nMSV.............L..I..AVSN..TKPKITKVLRITSTS......LTLFDALYNTVLTFFRSI.G..ArNVDVVRRLILYQASLS----.----------gphrdapih.........
M4JZ51_ELHV1/24-243                 .....................ss-RCYNNTLTCLN.GG.N--..........--VS.......FGDI...P...DYP...SNYSKL...IRYNSsSTI.KVPMK..YPLDEKLYNVLPLFYKNEDDLRVFLSLKKDSNGT-.WERNLigvpdlktvqeeeRQ.............YVFC-.DNAYAIFYC..S..QytKN....C...N..NnINLNKISYSNSIFTEHVLE..IVFH.gKPElrVDV.............K..I..LLYN..KVTLAHRIVTIPLFT......PALLDVTFNIIYRILYRD.P..A.SHALLKTFKKFFDQ------.----------higepyrgpr........
A0A1P8VIY7_9BETA/36-247             ......................a-DCINLAQSCAQ.SK.EIK..........LLEN......sTDNV...I...TNY...SAISYL...LSYDP.QHS.DINPS..TVVTQDFMKHFKLLKDNPNQLRVLLTLIKDKTNTN.LAKVF.............SK.............ITTC-.-SRNIIYTC..S..N..NI....C...K..T.HDLNNLLYTPNIFIENIKT..INIT.fVPQfkLTF.............T..V..ILINpiNNEKCESVID--YDN......LQTYDAIYNSLKYFSISA.G..I.ELPILKSLDKMAPNLPGRTK.TTHILI----rqe...............
GL_MUHVS/52-264                     .....................eh-KCREALASCYN.GS.EFQ..........PLHD.......DGPI...R...PDP...YRFSTM...IRFKR.SYG.ELPLP..IELNDEFLEQLSLLHNNTDQLRVLLTLMRTSRASD.WMSFL.............GG.............YTQCD.APKSVVFTC..V..E..SV....C...Y..E.HDLMRLNYTTDLFTENVLG..LDVS..PPV..LSV.............L..V..LLRN..NHTKAESVVRVPTSS......MSLLDGTYNLLRTILGHM.S..L.DTDLIGVLRSYRDRFPAVFSvSDQIKITRQH..................
GL_HCMVA/45-268                     ......................a-ECPELTRRCLL.GE.VFQgdky.eswlrPLVNvt...rrDGPL...-...---...---SQL...IRYRP.VTP.EAANS..VLLDDAFLDTLALLYNNPDQLRALLTLLSSDTAPR.WMTVM.............RG.............YSECG.DGSPAVYTC..V..D..DL....C...R..G.YDLTRLSYGRSIFTEHVLG..FELV..PPS.lFNV.............V..V..AIRN..EATRTNRAVRLPVSTaaapegITLFYGLYNAVKEFCLRH.Q..L.DPPLLRHLDKYYAGLPPELK.QTRVNLPAHS..................
G8XUH3_9BETA/16-238                 .....................dn-ECVTLVRQCIS.GE.SVLnttlngtnydPLV-.......-KPT...-...TDD...GMLSQL...IRYNQ.STV.STVRG.kINVDEQFIDQLALLHNNTKQLRVLLSLLQSDSAPL.WMRAM.............SG.............YGSC-.GQESAIYTC..Y..E..DV....C...R..G.YDLSNLTYVNTIFTENVLG..FEYL..PSS.rFSV.............L..L..VIRN..EGSKLNRPIRIPVNMr...tgLSLFYAVYNAVKGFFAEN.Q..L.QSPLIDRLDKYYHDLDEAYK.LPKTNVP---rvr...............
A0A1L6Z0F1_9BETA/23-244             .....................nl-TCLELTRRCFT.GE.TFS..........PEDDs.....wAKPL...IkvsHPD...GNLSQL...LRYTP.LTK.HAAST..IPLDDTFMDFVALLHNNPAQLRTLLTLLKSDGAPT.WMKIM.............QG.............YSECG.DT-GSIYTC..V..D..NV....C...R..A.YDLRYLTYSSSIFTENVLG..FDFG..HKG.qFAA.............L..V..VVRH..EDIKMHRPVRIPVATradrngLQLFYALYNLVRELLVRH.D..L.DTALIDRLDKYYLDIPDDWK.Q---------pltnnpal..........
A0A0K1H0F4_9BETA/23-244             .....................nl-TCLELTRRCFT.GE.TFS..........PEDDs.....wAKPL...IkvsHPD...GNLSQL...LRYTP.LTK.HAAST..IPLDDTFMDFVALLHNNPAQLRTLLTLLKSDGAPT.WMKIM.............QG.............YSECG.DT-GSIYTC..V..D..NV....C...R..A.YDLRYLTYSSSIFTENVLG..FDFG..HKG.qFAA.............L..V..VVRH..EDIKMHRPVRIPVATradrngLQLFYALYNLVRELLVRH.D..L.DTALIDRLDKYYLDIPDDWK.Q---------pltnnpal..........
G8XU04_SCMVC/22-243                 .....................nl-TCVELTRRCFA.GE.IFT..........PYNDk.....wSQPLidvS...QND...GNISQL...LRFDP.STK.HASPT..IPLDDTFMDYLTLLHNNPNQLRVLLALLRSDVAPT.WMTLM.............KG.............YSECG.DTG-PVYTC..I..N..DV....C...R..A.YDLRRLTYGQSIFTENVMG..FEFG..DQG.qFST.............V..L..VLRN..PHSKTHRPIRIPVATrakrdgLQLFYALYNFLREFFIRH.N..L.ETALVERLDKYYQKIPDEFK.QPVVN-----npal..............
K7XWE4_RCMVE/50-261                 ......................s-TCRDVLIKCYN.AT.AYT..........PIFG.......DGPL...-...RPV...IEFSTL...IKYKR.AYG.GFPSP..IKVDDEFLKQLALLYNNENQLRVLLTLLKSKREKD.WLSFL.............NG.............YNECDyHYKSSIFTC..V..N..DT....C...T..E.HNLLKLNYTNDVFAENVIG..FDIS..PPS..LYV.............L..V..LLRN..NKTNTEEVIRVPTIS......MSLFDATYNLVRSITEIT.G..F.GQDLSDTVRDYRKLFPTLFTnSDLGK-----iiprh.............
H2A2D9_MUHV1/52-264                 .....................eh-QCRDALASCYN.GT.EFK..........PLHD.......DGPI...R...PDP...YRFSTM...IRFKR.SYG.ELPLP..IELNDEFLEQLSLLHNNTDQLRVLLTLMRTSRASD.WMSFL.............GG.............YTQCD.APKSVVFTC..V..E..SV....C...Y..E.HDLMRLNYTTDLFTENVLG..LDVS..PPV..LSV.............L..V..LLRN..NHTKAESVVRVPTSS......MSLLDGTYNLLRTILGHM.S..L.DTDLIGVLRSYRDRFPAVFSvSDQIKITRQH..................
GL_HCMVM/45-268                     ......................a-ECPELTRRCLL.GE.VFEgdky.eswlrPLVNvt...grDGPL...-...---...---SQL...IRYRP.VTP.EAANS..VLLDEAFLDTLALLYNNPDQLRALLTLLSSDTAPR.WMTVM.............RG.............YSECG.DGSPAVYTC..V..D..DL....C...R..G.YDLTRLSYGRSIFTEHVLG..FELV..PPS.lFNV.............V..V..AIRN..EATRTNRAVRLPVSTaaapegITLFYGLYNAVKEFCLRH.Q..L.DPPLLRHLDKYYAGLPPELK.QTRVNLPAHS..................
Q9DW84_RCMVM/98-309                 ......................p-RCRENLIICQNtSS.NFT..........TMIA.......EGPI...R...PKA...HHYSSL...IRYRQ.ERG.MLRVP..LEVTDDFLFQLVLLHNNTEQLRVLLTLLRSIRGED.WMSYL.............AG.............YNECG.HPNSNIFTC..V..H..DV....C...T..Q.HDLLRLEYTNDLFVEDVIG..FELF..PPV..MAV.............L..V..LLRN..KATKTSGVVRLKAET......VSLLDATYNLVRTVFDDIpG..L.GRDLIETLYLYRERFPAVFSiS---------eeyrart...........
I3VQA5_9BETA/23-239                 .....................tg--CASAVKRCQF.IN.DSN..........IIRTe....gvGETI...I...KND...RIFSQL...IRYTP.ERR.HIQTP..IEVNEDFLSSLELLYNNDNQLRVLLSLMRSDFPHP.WIKLM.............RG.............YGSC-.ADYSIIFTC..V..N..DV....C...Q..E.HDLSKLQYASSIFTEDVIG..FELKhnPFS..LTV.............L..L..AVRN..KSTKTNKVITIPASN......IGLFNALFNSVKYFFIIH.N..MrDAPLLRKFTEYFLALDKPYR.----------erpianllirs.......
GL_HHV7J/30-245                     .....................eq-ECIKNILNCTQ.SK.T--..........-LSL.......LEPI...D...QAP...IPKSDIisrLLYHT.PYI.SRRDQ..VLIDEDFLETFYLLYNNPNQLHTLLSLIKDSESGHnWLGFL.............NN.............FERC-.LSDNTLLTC..R..D..NV....C...K..S.YSYEKLKFTGNIFVENIIG..FEFN..IPS..NMInfn.......msiL..I..YLEN..EETRTQRIVRIDHHG......INVFDALLNCLRYFSRYY.N..F.SFPLIQEMEKYNEVLP--FR.SEFSNLLIR-t.................
Q91TI6_TUHV1/104-323                .....................dp-DCFEAVTQCLL.RP.GER..........PSHRld..edpSRPL...F...PRR...WVFSEF...LRYRP.QTSgNLTGP..ISIDREFLDALALLYNNEDQLRVLLTLLRSDRAPD.WIKLL.............HG.............YGDC-.VSHSTVYTC..V..A..DR....C...R..E.HDLTRLQYTRTLFTEDVLG..FELR..PPF.gLSV.............L..V..ALRN..KNTKTESAVRIALDQ......IALFDAVFNVIKHYLLTH.R..LhDAPLLRQLNAYHRRLAAPYReSPPPNLLR--rt................
A0A191S3V8_9BETA/31-249             ......................k-ECINAIKNCTQ.SE.R--..........PIL-.......LEPI...D...QAP...TPNPDVisgLLYYT.PYS.FDEYQ..VLVDEEFLNTFYLLYNNPNQLHVLFSLIKDSKSKSsWLGFL.............NS.............FEKC-.FSDNTIITC..R..N..QV....C...K..T.YSYENLKYTPNIFVENIIG..FEFY..ISEnnLDVsfn.......ssiL..I..YLQN..EETRAKKIVKIMYEG......INVFDALLNSMRYFSQKF.QfsF.DFPLLREMESYNDLLP--FR.SEPSNLLIR-t.................
I3WEZ6_9BETA/23-244                 .....................nl-TCLELTRRCFT.GE.TFS..........PEDDs.....wAKPLikvN...HPD...GNLSQL...LRYTP.LTK.HAAST..IPLDDTFMDFVALLHNNPAQLRTLLTLLKSDGAPT.WMKIM.............QG.............YSECG.DT-GSIYTC..V..D..NV....C...R..A.YDLRYLTYSNSIFTENVLG..FDFG..HKG.qFAA.............L..V..VVRH..EDIKMHRPVRIPVATradrngLQLFYALYNLVRELLVRH.D..L.DTALIDRLDKYYLDIPDEWK.Q---------pltnnpal..........
#=GC seq_cons                       ........................pChphstpChp.uc.sh...........Ph.s.......tpPl.......pss...s.hSpL...lRYps.sst.ptsss..l.lD-pFh-tlsLLaNNssQLRsLLoLl+ocsuss.Whphh.............pG.............YspC..sspssIaTC..l..s..sl....C...+..t.aDLppLsYssoIFTENVlG..F-ht....s..hsl.............L..l..hlRN..pso+sp+slRIPhso......lsLF.AlaNhl+phhh+p.s..l.stsLlcpLccYatplP..a+.p...........................
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