#=GF ID DAAD
#=GF AC PF18752.5
#=GF DE Dictyosteliid AID/APOBEC-like Deaminase
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Iyer LM
#=GF GA 25.00 25.00;
#=GF TC 26.30 41.20;
#=GF NC 24.70 24.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF CL CL0109
#=GF RN [1]
#=GF RM 29555751
#=GF RT Diversification of AID/APOBEC-like deaminases in metazoa:
#=GF RT multiplicity of clades and widespread roles in immunity.
#=GF RA Krishnan A, Iyer LM, Holland SJ, Boehm T, Aravind L;
#=GF RL Proc Natl Acad Sci U S A. 2018;115:E3201.
#=GF DR INTERPRO; IPR041061;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A family of secreted AID/APOBEC-like deaminases found in
#=GF CC dictyostellids that often shows lineage-specific expansions [1].
#=GF SQ 14
#=GS F4QCW2_CAVFA/29-321 AC F4QCW2.1
#=GS F4Q3R9_CAVFA/25-332 AC F4Q3R9.1
#=GS A0A151Z4F6_TIELA/26-364 AC A0A151Z4F6.1
#=GS A0A151Z4J1_TIELA/28-356 AC A0A151Z4J1.1
#=GS A0A151ZF56_TIELA/27-156 AC A0A151ZF56.1
#=GS F4QCW3_CAVFA/66-381 AC F4QCW3.1
#=GS F4QCW1_CAVFA/26-301 AC F4QCW1.1
#=GS F4Q125_CAVFA/42-377 AC F4Q125.1
#=GS A0A151Z3Y8_TIELA/25-356 AC A0A151Z3Y8.1
#=GS A0A151Z3H3_TIELA/25-357 AC A0A151Z3H3.1
#=GS A0A8J4PVK9_9MYCE/20-230 AC A0A8J4PVK9.1
#=GS A0A151Z3H1_TIELA/25-345 AC A0A151Z3H1.1
#=GS A0A151ZF56_TIELA/151-305 AC A0A151ZF56.1
#=GS F4QES3_CAVFA/25-335 AC F4QES3.1
F4QCW2_CAVFA/29-321 .....................FDSNEKVRDDLHPyimahtegvkdmrhgQYAFAFYGSL.......GAQGGAFPLNRFKSL..................DLTTLG--TSYYVCDINNFRYFKQEEE....-ITVKNPINYKIVRQVTKAPPIVAAPIAVL...QTISKITTSPItrKVSSSnrlvISKILFTPSPNWYTNP---------------...............--------------FDTSTLSIIHVLN...LNGRGAML.....................-KPLPPTTPIAYKINSE..ETVTNLLLPKNI......................ENERLYlsFSRQWDIDYCHYINILQLSAptRGIQVV.SAATNRYGDRHVGYQSTLVTELERSS.MINIrrpdgs..ivselfTFPTTFKS..REFN...W..--.........QYLINQAF..........
F4Q3R9_CAVFA/25-332 .....................FKSDTEVITDLKYyiwahsagnddfihgQYGFTFYGEL.......---SLNYSPDQFSGV..................PLEAPA--NSYLTFDAATFKYFYINRK....ATSQPNNIYIDIIKN-ANKGAITTAPTMVL...QTMYKEYDSPF..HSESM....GIKSLFYFTSY---KPTVARQPIRYLYTLHH...............PCSICTSKIKSPNFINSRASDAIRADI...INGKGGTY.....................---PPPTTDVTYWIDSG..ESVNNLLYPVNP......................VTDHLYmvFSRQWDSDYCHYFNVRQLLS.qPGIQVV.AAATNRFKILKDNYQNILVASLLGDS.MVLNrnpnkggkpvkvpfSFETTSTD..-EYV...W..--.........QYVVDQAY..........
A0A151Z4F6_TIELA/26-364 .....................FGLNAPMFSDMNR...............QWGMITFGKLptetftlGDSCTIKREPKNPTSgk.............esfGFTHMVGFVDDNTCYADDNLFDGLFDPwkifVRPAPIPIPLSKATSQPKEPVKSKSPTPVEaapSAPLFRRATPS..YINAEtlslVDSYILSQIDSELPSPNNRGKRSGGPLDEELp.............pAKSTKSRDTIFGKELKFSVQSYYGHKQ...VYAR-TLYlhseiqlinaiahsdggiaklTDVYQPLYLFSYHFPCF..YCTDTLTHLNRD......................MNSYIY..YTYQWDKDYVHWQNQEKFFR..KNWIMV.PTPPDP-ILADKDYKDPLIPHFDTKRtKFG-..............HYPISFSDnlKDFL...CheER.........GFLKRDGF..........
A0A151Z4J1_TIELA/28-356 .....................FGLNAPMFNQMNR...............QWGMITFQKLpkqtftlGDSCTTRREPKNPKKe...............sfGFTHMVGFLDDNTCYADDKLFNGLFDPwnifGQPAEIPEPLSEATSQPEPPVKAAPPTPLF...SVATPSKAKKV..KILSL....VDSYTLSQIDNVLPPPTNNRGKSSGGPIDEP..............pAKFAKSRYSVFRDKLKFAVQSYSGYKQ...DSAR-TLYlhseiqlinaiahsdggieklTDIYQPLYLFSYHFPCF..YCTDTLTHLNRD......................MNSYIY..YTYQWDKDDVHWQNQEKFFR..KNWIMV.PTPPDP-ILADKDYKDPLIPHFDTKRtKFG-..............DYNVSFNDnlKDFL...CheNR.........GFLKRDGF..........
A0A151ZF56_TIELA/27-156 .vreilynnfyqeqvetgdin------------Ylwat.......pklaQWGFIITEPF.......SNPNTNLAVNRRNPL..................AYIHKSVRESF----IDDGTSYLDRLP....CLGATGNAF-TVQQCPAEIGLDQKTNFYLA...QKMTALVDEQH..HSEAT....IFRFLE-------------------------...............---------------------------...--------.....................-----------------..------------......................------..--------------------..------.--------------------------.----..............--------..----...-..--.........--------rn........
F4QCW3_CAVFA/66-381 .....................FDSNEKVRNDLHKyimahtegvkdmrhgQYAFAFYGSL.......GAQGGAFPLNRFTSL..................DLTAQG--TSYYVCDINDFRYFKEKEE....-IIVKNPINYNIIREETNQPPIVAAPITVL...QTMSKLTTSPY..HSESV....IIKSLGYFTDPNYPKPKLVYQPIRYLYTQYH...............PCSVCTTKIMNSSFVNDMTNDNIRIRN...LNGLGAML.....................PSTPPPTTPIAYKINSE..ESVTNLLLPSDT......................SKERLYlsFSRQWDIDYCHYINIRKLAA.kPGIQVV.SAATNRYGDRHVGYQSTLVTELERSS.MIDTrrpdgs..ivselfTFPTTFKS..RESN...W..--.........QYLINQAF..........
F4QCW1_CAVFA/26-301 .....................FDSNQDVRDGILPyiwvhsegqkefshgQYAFAIYGKL.......------GGLDVLKGV..................DLKNKDPKTSFTVCDAGNSRYFEKVHT....---LDKNNF--NIERLPDTKATTAAPTIAL...QTMSELFKSPF..HSESM....IIKSLFYFTHPAHPVPALSPQPIR-------...............-----------------IASDRVRANN...ING-----.....................----PKVEPYPTPEPDS.gDSVTNLLYPTDP......................TTQRLYvlFSRQWDLDYCHYFNVRQLAD.tPGIQVV.SAATNRDKIIQVGFQSLLLIELLRMS.TIDLsqpdgs..kkqetfIFPTTSAS..LDDN...W..--.........KYLIDQAF..........
F4Q125_CAVFA/42-377 .....................WLDDDEVRKYLYPyitvdtlenqdlkhgQYGFVIYGPT.......SYSCEVKVADGMGGMstitkmlptsdaklsarfPITSSAP-ESYKTFDVGLHGYYTIDYD....QSEKTNNVFLSYAKNYAKTDL-YKVPLYAWyakQAIWKEYDTPF..HSESM....ILKQLDLAINDA-DIPDMSVQDNIYMYTQNF...............PCSICTSKLVTKEFVNNRKADYELSKQ...LNGIGD--.....................FKIVQPINFNEQFLSVDaaYGIKNRLLPQDT......................EKQRTYlsFSRQWDNDYCHYGNVLSLYQ..-TYQVV.AAPINRHSFVIGTAQDVLLEFVLGSTkLFNLpqkd.....kdpyfRFNLRAQS..QDAQtaaF..--.........KYMIQDAF..........
A0A151Z3Y8_TIELA/25-356 .....................FGLDLPMFKDMDF...............QWGMITMEYLnke.sfnHQSCSQTETNTRVGKe...............ifGWKHMVGYEGG-KCKADENLFSTLFNP....KAQVALPTFAASTTVQRSTPGNSNAATSSS..aPGTTPVSNTVA..HNTPTnrmdVTKPPEEEEEVVEDKKSNTKKRGRTESNQSDsdtkd....snreesEKKPKYADHITGENLKFAVQSQTKVQE...VDGFRKLYehteiqllnaliaseygiqklKDKSYPLFLYTYHFPCW..YCTATLMEIKRT......................ENKKIY..YTYQWNRDYQHWKAQDRLLT..KGWTLV.PTTIDS-LLANTAYTDPLGKET----.TFG-..............YFNITFNQniKDFL...W..NR.........GQLNTFGF..........
A0A151Z3H3_TIELA/25-357 .....................FCLDLPMFKNMNF...............QWGMITMEFLskd.ifnHQSCSKTTSIKILDAtl.............pifGWKHMVGYEGG-TCKEGPHLFSAIFDP....----------TITIEQISTPGNSNTATSSAapgTTPLPSSTVAH..NTQPTrmgvTTKEGVVVKDSQVVSKKRGHTDMKESDVQEHvrdhtannrrpilesEKRPKYPDVITGEKLKFAVQSQTGAKEgdqEDSEVELHkhteiqllnalivshegvkkiQNTSNPLFLYTYHFPCW..YCTLTLLNLKRT......................TNKIIY..YTYQWNRDYQHWQTQDRLLY..RGWTLV.PTTIDS-SLANTDYTDPLGKET----.TFG-..............YFNITFNQniKDFL...W..NK.........GQLNTIGF..........
A0A8J4PVK9_9MYCE/20-230 wnevpvdvidqldkmydiifp-------------...............----------.......---------------..................---------------------------....------------------------------...----------K..HSKAP....ISQFGFAFNPSTLEAQSFEYPNSE-----WTilid.......gdkkVVRIKGDQSKFREKLEKFDQDQFIIVQm.mDDQKKAPYhsesiile....vmntyeglkSKCQNGFYLFTKFMPCT..HCTQKLLLERQGqaqptfrsermsqllkpfvpftTTSKFYllYSFQFDEDKLHYENLLKFQI..SNIFLV.R-------------------------.----..............--------..----...-..--.........--------ygynswkegk
A0A151Z3H1_TIELA/25-345 .....................FGLDLPMFKNMNF...............QWGMITMEVLtkd.sfnHQSCSKTTQNIF---..................GWKHMVGYEDG-TCKEGDALFLAIFNP....TGGAQRPTFAASTTVQRPAPGNSNTATSSSapgTTPLAPNTVAL..NTQPTtkmdVTKPPEEEIE-----KKNLKKRVRTESNQFDsdikd....fekeasGKKPKYADYITGEKLKFAVQSQTAAQE...--GGRELFkhteiqllnaliasedgvqklQDTNYPLFLYTYHFPCW..YCTTTLSNLKRT......................TNKIIY..YTYQWNRDYQHWKAQDRLIA..KGWTLV.PTTIDS-RLANTAYTDPLGKVT----.TFG-..............AFKITFNEniKDFL...W..NR.........GQLNTIGF..........
A0A151ZF56_TIELA/151-305 ...................rf-------------...............----------.......---------------..................---------------------------....------------------------------...-----------..-----....-------------------------------...............-------------------------LE...RNGLETGF.....................HESITGLHLYTSHMPCY.qFCTQKLASPDPNydrfk............fnfggITRKVY..FTVQWDHDVIHFQSLLLFKNnpNAWELVlEGRATENKYLYRDIVSPLQEIMARTFvSNGI..............SFPSGPGD..TPFDkmlWviENvffpmfhiiGEYDDKSF..........
F4QES3_CAVFA/25-335 .....................FKSDTQVITDLQYyiwahsagnndfihgQYGFTFYGEL.......---SGDYSPAKFSGV..................PLVAPA--NSYLTFDAYQFKYFYINQK....ATAQPNNIFIDLLPNQANKGANTYAPTMVL...QTMFKEYDTPF..HSESM....GIKSLFYFTTG-GFKPTVAPQPIRYLYTLHH...............PCSICSSKIKSPNFINSRASDAIRADI...INGKGGTY.....................---PPPTTDVTYWIDSG..ESVNNLLYPANP......................VNDHLYmvFSRQWDSDYCHYFNVRQLVS.qPGIQVV.AAATNRFKVLKDNYQNILVDSLLGNS.MVLNrnpvkggnpvsvmfTFGTTSTD..-EYV...W..--.........QYVVDQAY..........
#=GC seq_cons .....................Ft.s..hhpshph...............QaGhhhht.L.......t..ssths.sph.sh..................shpp.s..puh.shchsshha.th.p........h..sh.hs.hpp.sptss.stssh.sh...pshh..hsssh..+opuh....lhK.hh..hss.....p.thp..p.......................pp.p.tp.h..p.lp.tsps.hthpp...hsGhtsha......................p...Phh.hoYahssh...ssssLhh.pps......................hsp+lY..aohQWDpDYpHa.N.cpLht...uhplV.ssshsp.thhpssYpssLhtph.t...hhs...............tFsho.ss..p-a....W.............t.l.spuF..........
//
