#=GF ID   DNA_pol_viral_C
#=GF AC   PF00336.22
#=GF DE   DNA polymerase (viral) C-terminal domain
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_107 (release 1.0)
#=GF GA   22.40 22.40;
#=GF TC   22.40 22.60;
#=GF NC   22.30 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR001462;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF SQ   29
#=GS DPOL_DHBVQ/566-788        AC Q66403.1
#=GS A0A0M3YV36_9HEPA/545-759  AC A0A0M3YV36.1
#=GS A0A5R9QK12_9BACT/16-185   AC A0A5R9QK12.1
#=GS A0A482KFS9_9HEPA/572-806  AC A0A482KFS9.1
#=GS A0A0A7DQ32_9HEPA/622-855  AC A0A0A7DQ32.1
#=GS A0A193AU50_9HEPA/586-804  AC A0A193AU50.1
#=GS A0A6A4V630_AMPAM/238-349  AC A0A6A4V630.1
#=GS M4Q3C2_9HEPA/607-840      AC M4Q3C2.1
#=GS M1G279_9HEPA/571-793      AC M1G279.1
#=GS A0A2U8SZH8_9HEPA/591-825  AC A0A2U8SZH8.1
#=GS DPOL_GSHV/637-869         AC P03161.1
#=GS A0A7K6B7D4_UPUEP/189-414  AC A0A7K6B7D4.1
#=GS A0A2R4L015_9HEPA/591-823  AC A0A2R4L015.1
#=GS A0A6A4VZM4_AMPAM/396-507  AC A0A6A4VZM4.1
#=GS DPOL_HBVD3/590-822        AC P03156.1
#=GS A0A6A4VVJ8_AMPAM/185-299  AC A0A6A4VVJ8.1
#=GS DPOL_WHV4/640-872         AC P12898.1
#=GS A0A6A4W1U0_AMPAM/472-585  AC A0A6A4W1U0.1
#=GS Q7T457_9HEPA/635-867      AC Q7T457.1
#=GS A0A8H7S0S6_9FUNG/585-744  AC A0A8H7S0S6.1
#=GS A0A193AUB1_9HEPA/535-757  AC A0A193AUB1.1
#=GS DPOL_HBVCJ/601-833        AC Q69028.2
#=GS A0A8J1JL04_XENTR/338-491  AC A0A8J1JL04.1
#=GS Q7TG38_9HEPA/614-836      AC Q7TG38.1
#=GS U3M9X7_9HEPA/653-886      AC U3M9X7.1
#=GS Q6RSG7_9HEPA/564-786      AC Q6RSG7.1
#=GS DPOL_HPBDW/566-788        AC P17193.1
#=GS I7LRB0_HBV/602-834        AC I7LRB0.1
#=GS A0A8H7S5Y4_9FUNG/59-218   AC A0A8H7S5Y4.1
DPOL_DHBVQ/566-788                   ................DQKFMKIEESRWIELRTVIKKIKIGAWYDWKCIQRFVGHLNFVLPFTKGNIEMLKPMYAAITNKVNFSFSS.AYRTL.LYKLTMGVCKLAI..RPKSSVPLPRVATDATPTHG--AISH.-..-ITGGSAVFAF.SKVR....DIHI...QELLMV..CLAK....I....M....IKP.RCILSDSTFVCH...KRY.QT......LP.WHFAMLAKQL....L...SP...IQLYFVPSKYNPADGPSR....HRPPDWTALTYTPL--------------SKAIYIPHRLCGT.....................................
A0A0M3YV36_9HEPA/545-759             lpapkaqkkallalnc---------------------IQPDTAYDFKIIQRLTGLLAWVAPFTDLSYLILQPLYEACVSHSDFSFTS.QYLSI.LTSNFTRYTAKTL..TPKVA--QPCIFVDASDTLAAATFSN.Q..RVFW---VISL.PSAL....PIHI...KETIAA..VVAV....SfhfpV....SRC.RALASDSMFVCY...KQF.KT......LP.LLFALRAYTA....L...RR...LAVAYVHTSANPADGPTR....HM---------------------------------------glpasapsmplpvplalsp..................
A0A5R9QK12_9BACT/16-185              gievdkakievisklp-------------------------PPTNVKGVRSFLGHAGFYRRFIKDFSKITRPMTQLLLKDVKFEFSDeCLQTFeLLKEKLTTAPILI..GPNWSLPF-ELMTDASDFAIGAVLGQ.-..RVEGRFKPIYFaSKTLnqaqENYTtteKELLAI..VYAF....D....K....FRP.YLILSQTTVFT-...---.--......--.----------....-...--...------------------....-----------------------------------------dhsalkylme...........................
A0A482KFS9_9HEPA/572-806             ..............ns--FGSLPQDRHKLKALTMLKSLPLNVPIDWKICQRITGLLGFLAPFTKCGYAALMPLYNVIQAKKAFVMHP.NYCKW.LTSLYSDLWPVA-..RQRSR--LCQVFADATPTGWGLVNYS.-..--TDSVRLGTF.SQPL....PIHC...AELLSA..CFAR....C....W....TGA.SLLGVDNQVVAS...GKY.TH......YP.WLLGCAAAWI....L...RG...TSFIYVPSDLNPADAPSR....GLLGFRRFPPPLLFVPSTGRTSLYARSPPVPGRQPVRVSFA.....................................
A0A0A7DQ32_9HEPA/622-855             .............psg----TLPQSKQQKWAIQLLKALPCYTIFDWKILQRLTGLLGFLAPFTACGYPALMPLYHAITQKNGFEFSP.AYKGF.LLRLYSRPLHVV-..RQRSS--TCQVFADATPTGWGL-VNH.Q..-LAL-YKSGRF.PRPL....PIHH...AELIAA..ILAR....C....W....SGA.KLLGTDNTIVCS...HKF.TH......FP.WLLGCTANWI....L...RE...TSFCYVPSELNPADAPSR....GFLGIRTAPPPLRFRPSTGRTSLFVVSPPAPTRMPDRVSF-v....................................
A0A193AU50_9HEPA/586-804             ............thih------VTKEKFQKLHDLLTSINTDVFYDWKILQRFAGHFNQIVAFSLFGSHILGPIYLAITNKADFCFTK.SYVTD.LRYVLNHVYDLRL..RASPKHIVPSVAADATLTHGGIATRQ.-..---GEEIQLTF.SEQR....PVHV...QELLIA..LVAL....L....C....FVP.KGLLSDSTFVVH...KQL.HT......LP.YALAAVGHYL....L...SR...AKVTYVHTSLNPADPVSRllanHSAPRWPLLVHTSL---------------------------vkplyip..............................
A0A6A4V630_AMPAM/238-349             ...........rthpq-----------------------------------------------------------------------.-----.-------------..---------AVAVDATPYQLGFADAS.A..A-----IAVPL.ERPM....PIYR...AEFLAA..LMAA....L....R....VPPgTTVYSDNQAVIH...NIH.KGr....cPPsWLPWMSALFA....C...RG...NSFRYVPSAANPADAPSR....W----------------------------------------grpre................................
M4Q3C2_9HEPA/607-840                 ..............pg---GTLPQDKHHQKALKLISSLPVNKPLDWKILQRITGLLGFLAPFTTCGYPALMPLYHAITRRQALKISW.PFKNF.LYSLYKQPLPVI-..RQKPA--ICQVFADATPTGWGL-VNH.SsaWLRQ----GRF.PRPL....PIHC...AELIAA..CLAR....R....W....TGA.RVIGTDNSIVAS...GKR.TS......FP.WLLGCVANWM....L...RG...TSFCFVPSALNPADAPSR....GMLGIPVAPPPLPFRPSTGRTSLFAVSPSVPPHLPDRVHFA.....................................
M1G279_9HEPA/571-793                 ..............ne--QYIQIEDSRWTELRTVIKKISVGKWYDWKCIQRLIGHIQFVLPFTKGNSEMLKPMYLAVKEQVNFSFSS.RYRNL.LYKLTMGVCRLTL..NPKVSLPLPRVATDATLTHG--AISH.-..-ITGGSAVFTF.SKVR....DIHV...QELLMS..CLAM....L....M....IKP.RCLLSDSTFVCH...KRY.MT......LP.WNFAVLSKQL....L...GK...VPIYYVPSKYNPADGPTR....KKPPDWTALTYTPL--------------SKTPYIPHRLCG-g....................................
A0A2U8SZH8_9HEPA/591-825             ..............ss--MGSMPQQKHVQKVRMILRSLPTHKPLDWKILQRLTGLLGYLAPFTAFGYPALMPLYTAIAHKQAFTFVP.AYRLF.LVNNYTHLYFVR-..RQHAM--SCQVFADATPTGWGLVNYYsG..RMEG----GTF.QSPL....PIHV...AELIAA..CVAR....C....R....SGA.RVLGVDNTIVCS...HRF.TH......FP.WLLACAANWI....L...GD...VSFVYVPSTLNPADAPSR....GLLGFRTFPPPLPFRPHYGRVSLYAESPPVSPRLKARVSFA.....................................
DPOL_GSHV/637-869                    .............nga---GVLPQDKHVHKVTTYLKSIPINQPLDYKICERLTGILNYVAPFTKCGYAALLPLYQAIASHTAFVFSS.LYKNW.LLSLYGELWPVA-..RQRGV--VCSVFADATPTGWGICTTC.Q..LISG-----TF.GFSL....PIAT...AELIAA..CLAR....C....W....TGA.RLLGTDNSVVLS...GKL.TS......FP.WLLACVANWI....L...RG...TSFCYVPSADNPADLPSR....GLLPALRPLPLLRFRPVTKRISLWAASPPVSTRRPVRVAW-a....................................
A0A7K6B7D4_UPUEP/189-414             .............ddt---SIQIPDDQWEKNRQIIKKISPMKEYDWKVLQRFCGHLNFLLLFTRIHRLLLHPIYQAITQKRNFCFSK.TYKLL.LLKMLAQRHKVKI..QPKQSWPLPRVATDATLDVG--AVSH.-..-ITGGWSHVNF.SKQR....HIHV...QELLILlsSFLRqccnK....L....VRP.RSILCDSRFVCL...KRF.NT......LP.WLFALRAVLS....L...RR...VCLYFVPSKCNPADGLTR....GRHPDWSVVYYLHL---------------------------gkplklparl...........................
A0A2R4L015_9HEPA/591-823             ...............g-AWGSLPQDHIRAKIQRCFRTLPCNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPIYHAIKLKQAFSFSL.TYKAF.LRDQYLTLHPVA-..RQRPG--PCQVFADATPTGWGLVCGQ.Q..RMRG-----DF.VSPL....PIHT...AELLAA..CFAR....C....W....TGA.KHIATDNSVVLS...RKY.TS......FP.WLLGCAANWI....L...RG...TCFVYVPSQQNPADDPSR....GRLGLLRPLPRLHFLPSTGRTSLYADSPPVPFHRPARVHFA.....................................
A0A6A4VZM4_AMPAM/396-507             ...........rthph-----------------------------------------------------------------------.-----.-------------..---------AVAVDATPYQLGFADAS.A..A-----IAVPL.ERPM....PIYR...AEFLAA..LLAA....L....Q....VPPgTTVYSDNQAVIH...NIH.KGr....cPPsWLPWMSALFA....R...RG...NSFRYVPSAANPADAPSR....W----------------------------------------grpre................................
DPOL_HBVD3/590-822                   ..............gc--YGSLPQEHIIQKIKECFRKLPINRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQSKQAFTFSP.TYKAF.LCKQYLNLYPVA-..RQRPG--LCQVFADATPTGWGLVMGH.Q..RMRG-----TF.SAPL....PIHT...AELLAA..CFAR....S....R....SGA.NIIGTDNSVVLS...RKY.TS......FP.WLLGCAANWI....L...RG...TSFVYVPSALNPADDPSR....GRLGLSRPLLRLPFRPTTGRTSLYADSPSVPSHLPDRVHFA.....................................
A0A6A4VVJ8_AMPAM/185-299             ..........frshqh-----------------------------------------------------------------------.-----.-------------..---------AVAVDATPYQLGFADAS.A..A-----IAVPL.ERPI....PIYQ...AEFLAA..LLAA....L....Q....VPPgTTVFSDNQAVIH...NIH.KGrcppswLP.WISEL---FA....H...RG...NSFRYIPSADNPADAPSR....W----------------------------------------grprevv..............................
DPOL_WHV4/640-872                    ..............ts--SGVLPQDKHVKKISRYLRSVPVNQPLDYKICERLTGILNYVAPFTLCGYAALMPLYHAITSRTAFIFSS.LYKSW.LLSLYEELWPVV-..RQRGV--VCTVFADATPTGWGIATTY.Q..LLSG-----TF.AFPL....PIAT...AELIAA..CLAR....C....W....TGA.RLLGTDNSVVLS...GKL.TS......FP.WLLACVANWI....L...RG...TSFCYVPSALNPADLPSR....GLLPVLRPLPRLRLRPQTSRISLWAASPPVSPRRPVRVA--ws...................................
A0A6A4W1U0_AMPAM/472-585             ...........rahqq-----------------------------------------------------------------------.-----.-------------..---------AVAVDATPYQLGFADAS.A..A-----IAVPL.ERPI....PIYR...AELLAA..LLAA....L....Q....VPPgTTVFSDNQAVIH...NLH.KGr....cPPsWLPWISALFA....H...RG...NSFRYVPSAANPADAPSR....W----------------------------------------grpreaa..............................
Q7T457_9HEPA/635-867                 ..............ts--SGVLPQDKHVKKLSRYLRSVPVNQPLDYKICERLTGILNYVAPFTLCGYAALIPLYHAIASRTAFVFSS.LYKSW.LLSLYEELWPVV-..RQRGV--VCSVFADATPTGWGIATTC.Q..LLSG-----TF.AFPL....PIAT...AELIAA..CLAR....C....W....TGA.RLLGTDNSVVLS...GKL.TS......FP.WLLACVANWI....L...RG...TSFCYVPSALNPADLPSR....GLLPVLRPLPRLRFRPPTSRISLWAASPPVSPRRPVRVA--ws...................................
A0A8H7S0S6_9FUNG/585-744             ............lptk-----------------------------------------------------------------------.-----.-------------..------PHLKVFTDASDLGWGLVYNM.T..TVSG--TWTPH.QRQQ....HINY...KELLTI..RHAL....Q....QpaltGKN.LHIYCDNTTTIAyinHLG.GT......HS.TMLMTLAKEIwlecLktnTR...IQLTYVPSQFNPADPPSR....QL---------------------------------------hhqlewqinhhffhllnhlwgphsinlfassqnhklp
A0A193AUB1_9HEPA/535-757             .............ths---GIFPSDDKVEKLGGLLAKLQSAVPYDNKILQRLTGHLAFFAPFTMTGYALLQPLYQAIQKGQGWQMSA.AYIKL.LQHFFSKLVPVR-..--AHVVGFPQVFSDATPSTV--AFVD.Y..-WTH--EVHAMpLKTL....PIHV...TELIAA..IWAV....Q....R....TGC.HILGVDNTIVVS...KKM.TK......YP.WLLACIANMV....L...RE...VSMLYVPSKLNPADLPSR....GLQ--------------------------------------mlsayphihpyrvqdkshislhvprvy..........
DPOL_HBVCJ/601-833                   ................GSWGTLPQEHIVQKLKQCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQSKQAFTFSP.TYKAF.LCKQYLNLYPVA-..RQRSG--LCQVFADATPTGWGLAIGH.R..RMRG-----TF.VAPL....PIHT...AELLAA..CFAR....S....R....SGA.KLIGTDNSVVLS...RKY.TS......FP.WLLGCAANWI....L...RG...TSFVYVPSALNPADDPSR....GRLGLYRPLLHLPFRPTTGRTSLYAVSPSVPSHLPDRVHFA.....................................
A0A8J1JL04_XENTR/338-491             .........gfvistk---------GIVMDSKKVSAILDWPTPKDRKAVQRFVGFANFYRKFIRNFSEVIRPITDLTKQKVKFNWSP.QAQRA.FDKLKENFTSVPIlaHPVPSQPF-TLEVDASECAVGAVLSQ.R..SVP--------.----....----...------..----....-....-....---.------------...---.--......--.----------....-...--...------------------....-----------------------------------------qgllhpvaffsrklskteqnydvadrellaiklale.
Q7TG38_9HEPA/614-836                 ................DENFMKIEESRWKELRTVIKKIKVGEWYDWKCIQRFVGHLNFVLPFTKGNIEMLKPMYAAITNQVNFSFSS.SYRTL.LYKLTMGVCKLRI..KPKSSVPLPRVATDATPTHG--AISH.-..-ITGGSAVFAF.SKVR....DIHV...QELLMS..CLAK....I....M....IKP.RCLLSDSTFVCH...KRY.QT......LP.WHFAMLAKQL....L...KP...IQLYFVPSKYNPADGPSR....HKPPDWTAFPYTPL--------------SKAIYIPHRLCGT.....................................
U3M9X7_9HEPA/653-886                 ............paga-----LPQTKHQSRALSCLKRLPTYVVLDWKLLQRLTGLLGFLAPFTACGYPALMPLYAAIQARRGFEFSP.AYKGF.LLQLYSHLLPVA-..RQRRA--VCQVFADATPTGWGL-VNH.-..QLAA-YKAGRF.PRPL....PIHC...AELIAA..CLAR....R....W....SGA.RVLGVDNTIVCS...GKF.TH......FP.WLLGCTANWM....L...RG...TSFCYVPSELNPADAPSR....GLLGILLAPPPLLFRPSTGRTSLFAVSPPAPFHRPDRVSFA.....................................
Q6RSG7_9HEPA/564-786                 ................DDKFMKIEDQRWNELRQVIKKIQIGKWYDWKCIQRFIGHLNFILPFTKGNVEMLKPMYHAVTHKVNFSFSS.SYRTL.LYKLTMGVCKLKL..NPKVSLPLPRVATDATLTHG--AISH.-..-ITGGCAVFTF.SKVR....DIHI...QELLMA..CLAK....L....M....IKP.RCLLTDSTFVIH...KRY.QT......LP.WHFAVLAKQL....M...QN...IQLYFVPSKYNPADGPTR....HKPPDWTALTYTPL--------------SKAIYIPHRLCGT.....................................
DPOL_HPBDW/566-788                   ................DQKFMRIEESRWKELRTVIKKIKIGAWYDWKCIQRFVGHLNFVLPFTKGNIEMLKPMYAAITNKVNFSFSS.AYRTL.LYKLTMGVCKLTI..RPKSSVPLPRVATDATPTHG--AISH.-..-ITGGSAVLAF.SKVR....DIHI...QELLMV..CLAK....I....M....IKP.RCILSDSTFVCY...KRY.HT......LP.WHFAMLAKQL....L...SP...IQLYFVPSKYNPADGPSR....HKPPDWTALTYTPL--------------SKAIYIPHRLCGT.....................................
I7LRB0_HBV/602-834                   ................GSWGTLPQDHIXQKIKHCFRKLPXNRPIDWKVCQRIXGLLGFAAPFTQCGYPALMPLYAXIQAKQAFTFSP.TYKAF.LSXQYMNLYPVA-..RQRPG--LCQVFADATPTGWGLAIGH.Q..RMRG-----TF.VAPL....PIHT...AELLAA..CFAR....S....R....SGA.XLIGTDNSVVLS...RKY.TS......FP.WLLGCTANWI....L...RG...TSFVYVPSALNPADDPSR....GRLGLYRPLLRLPYRPTTGRTSLYAVSPSVPSHLPVRVHFA.....................................
A0A8H7S5Y4_9FUNG/59-218              ............lltk-----------------------------------------------------------------------.-----.-------------..------PHLEVFTDASDLRWGLVYNM.T..IVSG--TWTPH.QRQQ....HINY...KELLTI..RHAI....Q....QpaltGKN.LRIYCDNTTTIAy.iNHFgGT......HS.TMLMTLAKEIwlecL...KTnirIQLTYVPSQFNPADPPSR....QL---------------------------------------hhqlewqinhhffhllnhlwgphsidlftssqnhklp
#=GC seq_cons                        ...............t.......ppphhtchhphhppl.hst.hDaKhhQRhsGhLsahhPFTtssh.hLhPhYtsIpp+.sFpFSs.tYpsh.Lhp.h.phh.lh...p.+ss..hspVhsDATPTthGhshsp.t...hpG....hsF.scsh....PIHh...tELLAA..shAt....p....h....sss.+hlhoDNohVhp...p+a.po......hP.WLhushAphl....L...Rs...sshhYVPSthNPADsPSR....th.s.......h.h................................................................
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