#=GF ID   DNA_pol_viral_N
#=GF AC   PF00242.21
#=GF DE   DNA polymerase (viral) N-terminal domain
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_107 (release 1.0)
#=GF GA   29.90 29.90;
#=GF TC   95.90 95.20;
#=GF NC   21.60 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR000201;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF SQ   20
#=GS DPOL_GSHV/4-390          AC P03161.1
#=GS A0A0M3YV36_9HEPA/29-339  AC A0A0M3YV36.1
#=GS DPOL_HBVCJ/4-352         AC Q69028.2
#=GS A0A0A7DQ32_9HEPA/6-374   AC A0A0A7DQ32.1
#=GS M4Q3C2_9HEPA/13-359      AC M4Q3C2.1
#=GS A0A193AU50_9HEPA/26-190  AC A0A193AU50.1
#=GS A0A2U8SZH8_9HEPA/19-212  AC A0A2U8SZH8.1
#=GS Q6RSG7_9HEPA/18-362      AC Q6RSG7.1
#=GS Q7TG38_9HEPA/68-427      AC Q7TG38.1
#=GS DPOL_DHBVQ/18-370        AC Q66403.1
#=GS Q7T457_9HEPA/5-388       AC Q7T457.1
#=GS DPOL_HPBDW/18-370        AC P17193.1
#=GS U3M9X7_9HEPA/6-405       AC U3M9X7.1
#=GS A0A482KFS9_9HEPA/24-227  AC A0A482KFS9.1
#=GS I7LRB0_HBV/4-353         AC I7LRB0.1
#=GS A0A2R4L015_9HEPA/4-341   AC A0A2R4L015.1
#=GS DPOL_HBVD3/4-341         AC P03156.1
#=GS M1G279_9HEPA/18-376      AC M1G279.1
#=GS DPOL_WHV4/5-393          AC P12898.1
#=GS A0A193AUB1_9HEPA/28-295  AC A0A193AUB1.1
DPOL_GSHV/4-390                     .....................fyqlfrniq-------------..---SLGEEEVQELLGPPEDALPLLAGEGLNHRV---------ADALNLQ.LPTADLEWIHKTNVITGLYSTQTE.KFNCNWKQPVFPKIHLDNNLFQKLENYFGPLTTNEKRRLKLVFPARFFPNATKYFPLLKGIKDKYPNYTIEHFFAAANYLWTLWESGILYLRKNQTTLTFRGK.P.YSWE..HRqL...eQHNGQQHKSNIRSQ...QISCMVANS....G.NLlythyhrdksSN.IQT.RNLSDNVFkKSKESTRvRC..YTYDKIQR.NRLGQLARIPCESKAP.S---EQQQSSLRSKGRDFRN.....QIQA.YNS...SRNKGY--T..TWH.....STTS..D..SIQSGS...KKKT..HT.........SN.SSFER......HT..PSFDN...EKSDRSPAGICR----GTE....SSNHLRSSQ.L---.............CLWRSFYYTKPCGTYCLHHIVSSIDDWGPC....................................................................
A0A0M3YV36_9HEPA/29-339             .............lelgqgplanqspnlqe-------------..-------------------------------------------------.-------GKHKAGFLNGLYMPNPPsVFNPNWLIPSHKTVTLHKEL---------PLL-LPSRTWKYLLPARFWPKVTHWYSPLKAVKDKYPGFESEHKIIVQNYLTKLFETGVLYKRASKHSWLVHSEvPlYQWE..KE.RiiskHHGQGIQQ--TDDL...RRSAASKAD....G.TI..........YGsTSK.NSTAKTGV.SISSKRC.QQ..DKKSTVAQaSRSCYYP-QAKLSRQR.SSKTAT--YRVGSTFRPS--.....TECS.SAS...TANSAST--..---.....----..-..------...----..--.........--.-----......--..-----...-------------------....---------.----.............------------------------------fgasstcnanrttiaistvgfkgqsaipdksgsifgsitdsscssnsknilqhdhvqhlrnhgrsshs
DPOL_HBVCJ/4-352                    ..............................SYQHFRKLLLLDD..EAGPLEEE--LPRLA----------DEGLNRRV---------AEDLNLG.NLNVSIPWTHKVGNFTGLYSSTVP.VFNPDWKTPSFPHIHLQEDIINRCQQYVGPLTVNEKRRLKLIMPARFYPNLTKYLPLDKGIKPYYPEYAVNHYFKTRHYLHTLWKAGILYKRETTRSASFCGS.P.YSWE..QE.L....QHGRLVFQTSTRHG...DESFCSQSS....G.IL..........S-.---.RSPVGPCV.R------.--..---SQLKQ.SRLGLQPQQGSLARGK.SGRSGSIWSRVHPTTRRPFG.....VEPS.---...--GSGHIDN..TAS.....STSS..C..LHQSAV...RKTA..--.........-Y.SHLS-......--..-----...TSKRQSSSGHAVELHNIPP....SSARSQSEG.PIFS.............CWWLQFRNSKPCSDYCLTHIVNLLEDWGPC....................................................................
A0A0A7DQ32_9HEPA/6-374              qlfqsiqsleegeveqllgppedalpllad-------------..----------------------------------ANLNHRV-AEELLLQlPLHAEI-WVHKAGGLTGLYSEKPK.IFNPEWKTPSFPNIHLRHDLCEHIDSRIG-LTKGEKRRFKLCLPARFFPNKTKYFPLHNAIKNYYPDHTLTHFFHTAHYLWTLWESGVTYLRTSQSSASFNGQ.S.YPWE..Q-.-....KH--------HTHG...KQQISSQSL....-.RL..........P-.--P.RSPATNSP.K----FR.GL..GKILGPKS.AKGSLAPSIGTLSGSL.G-TKSSPSSWGSTWNRREFS.....GSPYqYQKy.rRNNQNYYRQktTNN.....YYKN..K..QDQSIY...WNNAnkTN.........IT.SHTSIqspkgaST..NAPDI...TSKTDSSTSQYE-------....QDLETEVRQ.PDNS.............CPWLFFNHSPACGRYCLRQCLLLLSDWGPC....................................................................
M4Q3C2_9HEPA/13-359                 ........slggeqgdalladpeealplla-------------..-------------------------DEDLNHRV---------AADLGLH.LPTTVEPWVHKVGGLTGLYSEKPK.SFNPEWKTPSFDNIHLRPDLIQYLQNRVG-LNPNEKRRLRLCLPARFYPNKTKYFPLSKGIKNYYPEHTLTHFFHTSNYLWTLWEAGITYLRESEKSASFKGQ.L.YPWE..QK.-....Q--------LISHG...TKLVHTQPV....G.IS..........S-.--R.TSTSKPLC.P------.--..------RL.SGLGLKSGQRSMATSK.GSVPGSLRARFCSPSWGPHGqsalcPRRQ.LNL...KQPRNHCLS..NPK.....SQGR..K..PDPSYS...ITSA..TP.........-H.HNQS-......--..-KEGA...STNSSYAPGQSH---TPPF....EHALLEGEVrSSHN.............CWWKQLQVADPCGDSCLSNILGLIDDWGPC....................................................................
A0A193AU50_9HEPA/26-190             .........qagtedyiirgqsgdlivqgk-------------..-------------------------------------------EDLDGG.VLPLQAEPERLLGPLKGLYQNDVP.PFNPSWEIPTIQGVHLQEDIIREI----------PDRRWAYIYPIRFWPNEVKYRPREQGITDKYPEHTRAHSEKVSLYLQTLYNNGILYKRESRHVLLFNDN.P.YSWE..S-.-....--------------...---------....-.--..........--.---.--------.-------.--..--------.----------------.--------------------.....----.---...---------..---.....----..-..------...----..--.........--.-----......--..-----...-------------------....---------.----.............------------------------------nnllpchchksqdye.....................................................
A0A2U8SZH8_9HEPA/19-212             ......qrvdllgppedvlplladadlnlr-------------..-----------------------------------------VADVLNLQ.LSQTAEPWVHKWGSLTGLYSLKEH.AFNKEWKIPSFPNIHVPADFIFKVSQLWGPLTKHELRRLKLLFPCRFFPRHTKYFPLQKGIKPRYPDYSLHHFLLTALYLHDLWTAGITYRRESYHSISFNGQ.L.YPWE..QK.L....HL------------...---------....-.--..........--.---.--------.-------.--..--------.----------------.--------------------.....----.---...---------..---.....----..-..------...----..--.........--.-----......--..-----...-------------------....---------.----.............------------------------------shgsqsehsksigvfpssqsrpdgp...........................................
Q6RSG7_9HEPA/18-362                 .............................a-EIKLRELENLVD..SN--LGEEELKPQLSMGEDVQSPGKGEPLHPSVRAPLSRVLLGTTTDLP.RLGNKDPARHKLGKLSGLYQMKGC.EFNPQWKVPDISDTHFNLDIINEC----------PSRNWKYLTPAKFWPKSISYFPVHSGVKPKYPDDVAGHEQIVGQYLTKLFEAGILYKRESKHLVTFKGT.P.YQW-..-E.R....QY--LVNQPADLHG...AAT--SKIN....G.RK..........KS.RRS.GTPPSTTG.RKDDPKR.DG..HMVRKISY.HGTHYGP----CANNG.RDKHHATTRGLAGRSREETG.....TNQP.ISP...CRSGDKLDT..GRG.....RQGP..R..IFQKIS...RRET..KR.........NH.HHSSH......KSteNSVGV...ETRRP-SPQHAT-------....---------.----.............------------------------------tvptsrtsgtgysgh.....................................................
Q7TG38_9HEPA/68-427                 ..............................AEKQLRVLENLVD..SN--LEEEKLKPQLSMGEDVQSPGKGEPLHPNVRAPLSHVVRAATTDLP.RLGNKLPARHHLGKLSGLYQMKGC.TFNPEWKVPDISDTHFNLDVVNEC----------PSRNWKYLTPAKFWPKSISYFPVQVGVKPKYPDNVMQHESIVGKYLTRLYEAGILYKRISKHLVTFKGQ.P.YNW-..-E.Q....QH--LVNQHHIYDG...ATS--SKIN....G.RQ..........TD.RRR.RNSVKPTC.RKDDPKR.DF..DMVRQVSN.ARSRVRP----CANNG.GDKHPPESGSLACWGGKESR.....IIKS.DSS...RDSSAPVDS..RGR.....PKST..R..SFSPLS...RRKT..TG.........NH.HHSSV......FP..SSVEA...TTRGRSTPGKSV-------....-SPRDSSAI.PV--.............------------------------------rtsgasdknspreeenvwylr...............................................
DPOL_DHBVQ/18-370                   ..............................AEKHLRELENLVD..SN--LEEEKLKPQLSMGEDVQSPGKGEPLHPNVRAPLSHVVRAATIDLP.RLGNKLPAKHHLGKLSGLYQMKGC.TFNPEWKVPDISDTHFDLQVVNEC----------PSRNWKYLTPAKFWPKSISYFPVQAGVKAKYPDNVMQHEAIVGKYLNRLYEAGILYKRISKHLVTFKGK.P.YNW-..-E.L....QY--LVKQHQVPDG...TTT--SKIN....G.RA..........EN.RRR.RAPAKSIS.RPHDSER.DC..NMVGQISN.NRSSIRP----CANNG.GGKHSSTTGRLACWGGKTIG.....TDQS.YSS...RDASASVDS..RGR.....SKSS..R..GFSSIS...RRKA..TG.........NH.HHCSY......VT..NSVEA...TTRGRSTPGKQV-------....-FTRDSSSL.P---.............----ESRASRACDK----------------dsspq...............................................................
Q7T457_9HEPA/5-388                  .....................srlfrniqs-------------..----LGEEEVQELLGPPEDALPLLAGEDLNHRV---------ADALNLH.LPTADLQWVHKTNAITGLYSNQAA.QFNPHWIQPEFPELHLHNELIKKLQQYFGPLTINEKRKLQLNFPARFFPKATKYFPLIKGIKNNYPNFALEHFFATANYLWTLWEAGILYLRKNQTTLTFKGK.P.YSWEhrQL.V....QHNGQQHKSHLQSR...QNSSVVACS....G.HL..........L-.-HN.HLPSEPVS.V---STR.DLsnNILG---K.SQNSTRT--GLCSHKQiQTDRLEHLARISCGSKTTIG.....QQGS.-SP...KTSSNFRNQ..TWA.....NNSSwnS..GHTTWF...SSAS..NS.........NK.SRSRE......KA..YSSNS...TSKRYSPPLNYEKSDFSSPgvrgRIKRLDNNG.TPTQ.............CLWRSFYDSKPCGSYCIHHIVSSIDDWGPC....................................................................
DPOL_HPBDW/18-370                   ..............................AEKHLRELENLVD..SN--LEEEKLKPHLSMGEDVQSPGKGEPLHPNVRAPLSHVVRAATIDLP.RLGNKLPAKHHLGKLSGLYQMKGC.SFNPEWKVPDISDTHFDLQVINEC----------PSRNWKYLTPAKFWPKSISYFPVQAGVKAKYPDNVMQHEAIVGKYLNRLYEAGILYKRISKHLVTFKGK.P.YHW-..-E.L....QY--LVKQHQVPDG...TTT--CKIN....G.RE..........EN.RRR.RAPAKSIS.RPHDTER.NC..HMVGQVSN.NRSPIRS----CANNG.GGKYSSTTRRMACWGGQTIG.....VNQS.CSP...RTSAASVDA..GRR.....SKSS..R..GLSSLS...RRET..TG.........NH.HHSTN......VT..NSVEA...ATRGRSPAGKQV-------....-SARDTSSL.P---.............----ESGASRACDK----------------nsspq...............................................................
U3M9X7_9HEPA/6-405                  .rlfrsiqslgeeevhallgppegalplla-------------..-------------------------DADLNRRV---------AADLSLQ.LPPTASIWVHKAGGLTGLYSDKPK.SFNPHWKTPEFPQLHLRPDLIEYLTHRLGPLTSAEKRRFRLCIPARFFPNKTKYFPLYKGIKPYYPDNLLTHFFLTSHYLRTLWEAGVTYLRETQSSASFNGS.P.YPWE..QK.-....QH---------NHG...TERINSKPSrvlpGtRS..........TT.RLR.KAGNGPCT.RP-----.-L..HLLGQSPL.QRSRQRE-ASSL--GK.GRSSPRLGSRTHTSTRRPFG.....VSRD.LPGgtnHFPPRWLDH..KNS.....NRQT..S..HHHSTStyqTKQA..KGgakgrilpnSYtTATSY......RT..HQSEAfsdTS-HNTTQSEQGEDTHSPY....SSGAGHSSS.PEHDqpdvegairpsplCAWSYLRSHPACGPHCLKQCTLLLDDWGPC....................................................................
A0A482KFS9_9HEPA/24-227             .............eappedalprladvgln-------------..-------------------------------------LHVADALNLQLP.EDLTAEQWVHKVGNLLGLYTEKPR.EYNKEWKTPRFPNIHLKETLITNLSNRFGPLTPAETRRFKLSLPARFFPVKTKYLPLHKGIKNYYPSDIIHHFITTADYLWTLWESGILYLRVSQKQATFNGS.P.YSWE..QR.R....LH----N------G...TQS------....-.--..........--.---.--------.-------.--..--------.----------------.--------------------.....----.---...---------..---.....----..-..------...----..--.........--.-----......--..-----...-------------------....---------.----.............------------------------------vcsepfrvssfsfnrshrrtrlgqkpsqrslat...................................
I7LRB0_HBV/4-353                    ..............................SYQHFRKLLLLDXetEAGPLEEE--LPRLA----------DEDLNRRV---------AEDLNLG.NLXVSIPWTHKVGNFTGLYSSTVP.IFNPEWQTPSFPKIHLHEDIINRCQQFVGPLTVNEKRRLXLIMPARFYPNSTKYLPLDKGIKPYYPDXVVNHYFQTRHYLHTLWKAGILYKRETTRSASFCGS.P.YSWE..QE.L....QHGRLDIN-SQRHG...DESFCSQPS....G.IL..........S-.---.RSSVGPRI.R------.--..---SQFKQ.SRLGLQPHQGPLATSQ.PGRSGSIRARVHSPTRRCFG.....VEPS.---...--GSGHIGH..GAS.....SSSS..C..LHQSAV...RKAA..--.........-Y.SHLS-......--..-----...TSKRQSSSGHAVEFHSFPP....SSARSQSQG.PIFS.............CWWLQFRNTQPCSQYCLSHLVNLLEDWGPC....................................................................
A0A2R4L015_9HEPA/4-341              ............................sc--QLFRKLLLLEG..DQGPLEEE--LPRLA----------DEDLNRRV---------AEDLNLQ.LPPVSIPWTHTVGEFTGLYSVTPL.RYNPEWKIPEFPNIHLKQDIIKRCTDFVGPLNANETRRLKLVLPARFYPKVTKYFPLEKGIKPHYPDQVVNHYFKVQEYLHTLWKSGILYKRETTHSASFFGS.P.YTWE..HQ.L....QH-----------G...TKPVYHQSS....G.VL..........P-.---.QSSARPLV.Q------.--..---SEFTS.SRLGSKSSQRPLAFSS.RSACRGLWTRPSSSSRRFAR.....LESS.---...VTGSS----..---.....----..-..-HPVAK...RSAC..ST.........AQ.SQLSQ......ST..HSHNT...TTKGHSSPSHDLEYLKLSE....GSSRSSSQG.AVFP.............CWWLQFRDSNPCSDYCLHHIVSLRDNWGPC....................................................................
DPOL_HBVD3/4-341                    ..............................SYQHFRRLLLLDD..EAGPLEEE--LPRLA----------DEGLNRRV---------AEDLNLG.NLNVSIPWTHKVGNFTGLYSSTVP.VFNPHWKTPSFPNIHLHQDIIKKCEQFVGPLTVNEKRRLQLIMPARFYPKVTKYLPLDKGIKPYYPEHLVNHYFQTRHYLHTLWKAGILYKRETTHSASFCGS.P.YSWE..QD.L....QH-----------G...AESFHQQSS....G.IL..........S-.---.RPPVGSSL.Q------.--..---SKHRK.SRLGLQSQQGHLARRQ.QGRSWSIRAGFHPTARRPFG.....VEPS.---...--GSGHTTN..FAS.....KSAS..C..LHQSPV...RKAA..--.........-Y.PAVS-......--..-----...TFEKHSSSGHAVEFHNLPP....NSARSQSER.PVFP.............CWWLQFRNSKPCSDYCLSLIVNLLEDWGPC....................................................................
M1G279_9HEPA/18-376                 ..............................AEQKLRELENLVD..LN--LEEEKLKPQLSMGEDVQSPEKGVPLHPNVRAPLSRVLQGVQEDPP.RLGDKSPASHKLGKLSGLYQMKGC.EFNPEWKVPDITQTQFDLDIINEC----------PSRNWKYLTPAKFWPKSISYYPREIGVKPKYPDNQKQHEAIVGIYLNKLYEAGILYKRNSKHIVTFKGK.P.YPW-..-E.T....KY--LVIQRQ-QYG...PKS--SKIN....G.HS..........SS.GRRgIIDTSNIS.APDKANS.SS..NSQWSVSI.NRTC----YGTCAGSG.RVKYFTQTRTLSGRNRACLG.....STQS.QAT...ISTSRDLDT..GRR.....QTGL..G..NLRQIP...GRTR..-G.........RI.KGVRK......ET..RSHQA..sTTTTKTA------------....---------.----.............------------------------------tcpcvesdrerdsfrrveylvaagstsnqsakgsq.................................
DPOL_WHV4/5-393                     .....................srlfrniqs-------------..----LGEEEVQELLGPPEDALPLLAGEDLNHRV---------ADALNLH.LPTADLQWVHKTNAITGLYSNQAA.QFNPHWIQPEFPELHLHNDLIQKLQQYFGPLTINEKRKLQLNFPARFFPKATKYFPLIKGIKNNYPNFALEHFFATANYLWTLWEAGILYLRKNQTTLTFKGK.P.YSWEhrQL.V....QHNGQQHKSHLQSR...QNSSMVACS....G.HL..........LH.NHL.SSESVSVS.T------.-R..NLSNNISDkSQKSTRTGLCSYKQIQ.TDR-LEHLARISCGSKITIG.....QQGS.-SP...KTLYKSISS..NFRnqtwaYNSS..RnsGHTTWF...SSAS..NS.........NK.SRSRE......KA..YSSNS...TSKRYSPPLNYEKSDFSSPgvrrRITRLDNNG.TPTQ.............CLWRSFYNTKPCGSYCIHHIVSSLDDWGPC....................................................................
A0A193AUB1_9HEPA/28-295             ......isqdapgddlplrladaanphvdp-------------..----------------------------------------------ALG.VLEVNRLSLHSLGHLRGLYDNPSL.TFNPEWSIPPFPHIHLHEDIIQRI----------PNRKWSLILPARLYAPGATYWKVHKAIKPKYPHYILEHVVLTTAYLLELYNKGILYKRHSDHVLSFCGE.P.YSWE..RK.I....ILNNYTTNGGSTIGpcsGRSEHSTSN....G.KE..........QD.SSL.RSKNRH-S.-KHPTGK.AT..GRASQTTS.TKFATAHSSTSSTKTT.SHRHSSFGNRCSSGTG----.....----.---...---------..---.....----..-..------...----..--.........--.-----......--..-----...-------------------....---------.----.............------------------------------adtpnqrqeensslprhhgaygssdgs.........................................
#=GC seq_cons                       .............................t...................LtEE.....Lu..........sEsLp.pV.........AtsLsLt.h.sssh.WsHKlGsLoGLYoppss.pFNP-WKsPsFPslHLcpDlIpchpphhG.Ls.tEpR+hKLlhPARFaPpsTKYFPLpKGIKspYP-pslpHahhsupYLpTLWEAGILYKRcSp+osoFpGp.P.YsWE..pc.h....QH.....p....pG...spo..spss....G.p...........p......pssspshs.p..............sphpp.s+.shts..t.hupst.sscp.shtsphsshs+p.hu......ptu.......htsss.htp..t.p......pss..p...hpsh....ppts..............h.pp.p............t.t....ooptposstp................t.psp..s........................t.sCs.....................................................................................
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