#=GF ID   DP-EP
#=GF AC   PF08985.15
#=GF DE   DP-EP family
#=GF PI   DUF1888;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   pdb_1ai4
#=GF GA   25.00 25.00;
#=GF TC   26.80 25.20;
#=GF NC   23.90 24.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0026
#=GF RN   [1]
#=GF RM   22493430
#=GF RT   Characterization of member of DUF1888 protein family,
#=GF RT   self-cleaving and self-assembling endopeptidase.
#=GF RA   Osipiuk J, Mulligan R, Bargassa M, Hamilton JE, Cunningham MA,
#=GF RA   Joachimiak A;
#=GF RL   J Biol Chem. 2012;287:19452-19461.
#=GF DR   INTERPRO; IPR015078;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The DP-EP family of proteins, formerly known as DUF1888 have
#=GF CC   been shown to catalyse a cleavage of an internal peptide bond
#=GF CC   [1].
#=GF SQ   36
#=GS I1DSP2_9GAMM/8-123        AC I1DSP2.1
#=GS A0A0C5VGV7_9GAMM/2-116    AC A0A0C5VGV7.1
#=GS A0A2N1DEG0_9ALTE/6-115    AC A0A2N1DEG0.1
#=GS A0A4R6ULC6_9GAMM/8-122    AC A0A4R6ULC6.1
#=GS K6ZTX8_9ALTE/6-115        AC K6ZTX8.1
#=GS Q12QP5_SHEDO/17-133       AC Q12QP5.1
#=GS A0A1U9NBJ1_9GAMM/52-192   AC A0A1U9NBJ1.1
#=GS A0A0F4PQT2_9GAMM/10-177   AC A0A0F4PQT2.1
#=GS A0A7X0JQA0_9GAMM/19-159   AC A0A7X0JQA0.1
#=GS A0A4R2FEL2_9GAMM/9-130    AC A0A4R2FEL2.1
#=GS A0A4R2FFV6_9GAMM/132-246  AC A0A4R2FFV6.1
#=GS A0A2T6FJQ8_9GAMM/25-166   AC A0A2T6FJQ8.1
#=GS A0A136A4P8_9ALTE/1-111    AC A0A136A4P8.1
#=GS A0A7H4GPG0_9GAMM/2-117    AC A0A7H4GPG0.1
#=GS A0A6M4MAK2_9ALTE/6-122    AC A0A6M4MAK2.1
#=GS A1S2N5_SHEAM/4-113        AC A1S2N5.1
#=GS A0A075P0U9_9ALTE/6-112    AC A0A075P0U9.1
#=GS A0A0N8TXV3_9GAMM/5-123    AC A0A0N8TXV3.1
#=GS Q8EGA7_SHEON/9-123        AC Q8EGA7.1
#=GS A0A839USY1_9GAMM/30-165   AC A0A839USY1.1
#=GS A0A6G9QI21_9GAMM/4-114    AC A0A6G9QI21.1
#=GS A0A1S2TNW0_9GAMM/6-115    AC A0A1S2TNW0.1
#=GS A0A1S2TNN6_9GAMM/12-128   AC A0A1S2TNN6.1
#=GS A0A248K0H5_9PROT/10-131   AC A0A248K0H5.1
#=GS A0A1Y0FZV6_9GAMM/48-198   AC A0A1Y0FZV6.1
#=GS B3PEJ4_CELJU/27-168       AC B3PEJ4.1
#=GS K2K8Z1_9GAMM/8-137        AC K2K8Z1.1
#=GS A0A4Q8TZY1_9ALTE/4-117    AC A0A4Q8TZY1.1
#=GS A0A7Y7DN01_9ALTE/7-121    AC A0A7Y7DN01.1
#=GS A0A0Q0I616_9GAMM/9-119    AC A0A0Q0I616.1
#=GS A0A0M2VIL3_9GAMM/1-114    AC A0A0M2VIL3.1
#=GS Q087B2_SHEFN/13-125       AC Q087B2.1
#=GS A0A0Q0HHY4_9GAMM/80-196   AC A0A0Q0HHY4.1
#=GS K4KMB4_SIMAS/15-154       AC K4KMB4.1
#=GS F7NX03_9GAMM/10-122       AC F7NX03.1
#=GS A0A094LNT8_9GAMM/4-125    AC A0A094LNT8.1
I1DSP2_9GAMM/8-123                   ....................................................................................................................................sl--IQVVVNLE-NGEPV-.FSY.QT.TS.GQP...LpNGD...IT.VT..............-EAGTLTYQLVD..N..TG..K...G......LKFVGVGFT....TP..FD...GIIDAI-TVSSDGQL.VQMLD.....MDR.-SAGSTK...FQF.VLTNTANT.......LMVLSPDPE.VKN--lp...
A0A0C5VGV7_9GAMM/2-116               ......................................................................................................................................QQIKFNVTVDTSVIPPI.FVF.YN.EN.KQP...T.NGS...VT.VH..............GEPTEICYVLES..P..G-..-...-......YFMQKPAIT....--..DD...FNHDITFTFEDNGKT.LVLVD.....QGS.RDNEDVG...LQL.VVESVKTG.......QRYASPDPR.IKNKR.....
A0A2N1DEG0_9ALTE/6-115               ......................................................................................................................................TNIIVTVNII-EGVPT-.FLY.EP.--.---...-.SGT...IH.VT..............-EATDVTFTLSD..A..CS..P...R......LTFEQPLIA...yVP..VN...EQRDITPSVESEGQV.LRLID.....TDV.-DEETIC...IQL.VVTDEYS-.......NSYASPDPR.IVNKP.....
A0A4R6ULC6_9GAMM/8-122               ...................................................................................................................................nls---TVQVSVD--FSSGS.FSY.SG.--.GTD...G.HGN...VT.TT..............-SPGDVTYTMTP..T..TD..S...S......LRFVGAVFL....NP..SDadiGRIK----VVEGGRS.LKVFD.....NYE.NPNDTIS...FLL.VVQNSANP......pQTIISADPQ.IINHP.....
K6ZTX8_9ALTE/6-115                   ......................................................................................................................................KNITVTVTIV-EGVPT-.FSY.AP.--.---...-.DGP...II.VT..............-ESTDVIFTLSN..T..SH..P...A......VSFKEPLIS...yVP..VD...ASRNITLSLSADEQS.LTLRD.....TDI.-DKEVIG...VQL.VIKDAYR-.......NTYASPDPQ.IINRD.....
Q12QP5_SHEDO/17-133                  ......................................................................................................................................EYVTVTVTLPTNPNEPAtFVF.NP.ST.PVV...L.DGS...GK.VK..............-------YIITN..E..D-..-...-......VVFVGAKFY....RD..DDdslQSVKIETNATQSILT.ITAEN.....ESK.TTDDDIA...FKV.VVAARDCDa....dgAIFQSQDPQ.IICRP.....
A0A1U9NBJ1_9GAMM/52-192              ....................................................................................................................................kt--FDLMPAKSTAAAPGD.WIF.TE.EG.STV...D.IEN...LV.VGfelnps..alnrqfERAILVIKIKQN..P..AS..G...Gt...wrFALGGVATD...nAD..SD...PDNDVIVDIIDNGYTmIVYVQ.....ALE.NSAEYIP...FGF.VASLTNQYtg...vvTIYESQDPG.IATRR.....
A0A0F4PQT2_9GAMM/10-177              vpcepgnvsvqeqlelipsvnepwqtyvvvngskqningqdypilftnnpahadlqptqhaelvvtisdndweffgngveyiknysncnynvdssisadkkqltlkvhqvdttfcygkaddspldqvievapss-----------------.---.--.--.---...-.---...--.--..............------------..-..--..-...-......---------....--..--...---------------.-----.....--T.AEPLSIG...FRF.TAKNTANG.......KYYMSQDPR.VIVRRp....
A0A7X0JQA0_9GAMM/19-159              ......................................................................................................................................KNFTLKPSLPANGQPGD.WVF.QT.--.-IE...S.DGS...QQpVEnldisf.dpnsnwlQRQSEVCVLVVT..M..DE..P...Gw....rFALGGTKSClseiNT..TD...QLHDVETAVTANGKVlTAVIK.....SLS.KVGEAVG...FSF.VAAHTSDDg....svNIYQSPDPG.-----leikr
A0A4R2FEL2_9GAMM/9-130               ...................................................................................................................................ykf---LVSISIDSKGVPD-.FTY.YEpGN.PTPlskE.QRA...VE.VD..............-APTVIFYELTN..L..ELspK...G......LKFVGAGFK....NP..YD...GIIENA-FVSEDGKT.LILED.....LCK.-DYGTTN...FHL.LAKCDRNN.......LIIISPDPE.VVNK-n....
A0A4R2FFV6_9GAMM/132-246             .....................................................................................................................................s---TVEVVIERNGNSGVdFSY.HQ.-N.GVA...C.SGD...ID.VT..............-SPTTLTYHISH..S..NI..A...G......LRFTGAGFL....NP..FN...GTIDSV-TVSDDGQT.LALED.....SYQ.-QSGIGK...FQF.LLKSDENT.......LVMISPDPE.VINR-g....
A0A2T6FJQ8_9GAMM/25-166              ......................................................................................................................................QYFNLTPALPTDTGRGD.WIF.TE.DG.STQ...D.IET...LT.VGfaenpl..plerelERAVLVISMVQN..P..SS..N...Gt...wrFALGGVATD...hGD..ED...PNNDVVVDIIDNGFTlIAYVQ.....VLE.NSAEYIP...FGF.VASFTDDDtg...vvSIYESQDPG.IV---pvrp.
A0A136A4P8_9ALTE/1-111               ....................................................................................................................................ms--INVSVTVNISNGEAS.FSY.AP.--.---...-.DGP...YN.VT..............-ETTDLVFTLSG..C..V-..P...D......LTFKDPLIS...yVP..VD...ASRDITPVLSHGNQT.LTLSD.....TDA.-DSETIG...VQL.VVQDTYG-.......NTYASPDPK.IINK-g....
A0A7H4GPG0_9GAMM/2-117               ...................................................................................................................................snt---PVTVTIA-NDQPPYrVTL.NP.--.---...-.PGP...YR.IT..............EPNSTITMQLDE..Q..SA..G...A.....gFKMFGIGFR....EPeaED...QLHANVTTTRHQDDT.LRVTD.....AKT.---ENGR...FEF.VVLYQDQGg.....gTTVYGYDPE.VDN--dd...
A0A6M4MAK2_9ALTE/6-122               ..................................................................................................................................qmkg----FTVAIKQNGDDIT.FDI.KD.EA.GND...A.TAP...IQ.ID..............APDTTIEYSLIN..N..N-..D...E......WIFCDPKVE....--..GD...DKQNLQITLGKNKQQ.VIILD.....SDA.-DNEDIC...LRL.VVARLATP......dVQYTSPDPQ.IKNKP.....
A1S2N5_SHEAM/4-113                   ......................................................................................................................................QNIQVTVSLDASNTPV-.FNY.AP.--.---...-.AGP...VV.VT..............ESGTQIVYSLQD..K..TG..K...G......LSFAGAAFA....TP..FD...RVIDAVELLNETT--.LALYD.....TDT.-IGGETG...FRL.VFNIAGST.......LQLCSPDPQ.VINKD.....
A0A075P0U9_9ALTE/6-112               ...................................................................................................................................pny---NYDVTVDANG---A.FTI.TP.ID.GAP...-.DSP...IT.VS..............VPNTTITYTLTD..N..TA..S...N......MVFVSPEIS....--..DD...PNGDLTWQVTNNGKS.IVITD.....SDA.SKEDHIC...VKL.VAA-----.......--FVSPDPQ.IKN--dp...
A0A0N8TXV3_9GAMM/5-123               ...................................................................................................................................qtf-NFTVNVKLNTENEAL-.FTY.FQ.-D.GQQ...V.SGG...GT.VN..............ERNSLGIYTLDD..A..TV..D...A.....gFQFTGAKFA...nLE..GN...CEQDFSFKVTNNGQT.IEIAD.....SDE.-NSGTAC...MIF.IVECNGT-.......-SYESADPQ.VEN--ek...
Q8EGA7_SHEON/9-123                   ......................................................................................................................................QFIKVNVTLE-NGEPV-.FIY.TD.AN.GQV...C.QGD...IT.VT..............-QAGTITYLLND..Q..TL..K...G......LKFVGVGFV....TP..FD...GIIDAV-TISSDGML.VQLVD.....LDK.-TPGTTK...FQF.VLSNTANT.......LLVLSPDPQ.IINRP.....
A0A839USY1_9GAMM/30-165              .............................................................................................................................kpenapfpi-----------------.WSL.LG.PD.GQP...A.DPN...SL.VVefdgqsanfermreRALLMVTLSTAN..T..TR..E...E.....rFKFFGNGLE....YA..DDredVNDDVTTDLTKDSQTlVFTIQ.....NQG.GTSSTVD...FGF.LVSRKNRNtg...elHIFEGPDPKiVIHRP.....
A0A6G9QI21_9GAMM/4-114               ..............................................................................................................................dskinviv-------TYE---QST-.FLY.NG.--.--S...P.KCQ...LV.VQ..............-QNTSIRFKLDS..A..TA..D...N......YRFAGVIFD....NP..ND...PDIGKV-SIKNQATE.LKIKD.....TYC.QHADEIS...FRI.VLTPLNTH.......ECIVSPDPQ.VLNRP.....
A0A1S2TNW0_9GAMM/6-115               ......................................................................................................................................KNIIVTITLDDNRVPQ-.FAY.EP.--.---...-.DGP...VV.VD..............KPNTHIIYKLQD..K..TD..M...D......LAFVGASFD....TP..FD...GIIDAVKTEAPDM--.LILMD.....TNS.-VVGKTG...FRL.ILSNSSNT.......LLVSSQDPE.VVN--tg...
A0A1S2TNN6_9GAMM/12-128              ...................................................................................................................................epv---VLSVTLD-SARQAS.FHY.SQ.-Q.GVE...C.SGD...VV.VS..............-EPAVITYQLLNleD..SP..A...G......LKFVGAAFT....NP..FD...GHIDRV-EVSADGLT.LQLHD.....SMR.-NTGTGK...YQF.LFSSEESP.......LLLASPDPQ.VINRP.....
A0A248K0H5_9PROT/10-131              .....................................................................................................................................p----ITITIT-AIAPNA.WTY.EG.PG.VDP...T.TGH...IT.LP.............nQGPTQIIYQLAE..D..LQ..D...T......YNLVFANLS....-P..TH...CITAQVTQITYGDST.ITIND.....AND.WGPGATGrrpFGF.ILVARLNDd....tgTAILSPDPE.VDNN-p....
A0A1Y0FZV6_9GAMM/48-198              ................................................................................................................qfyeltpvlpkansngtlvaqp-----------------.WIL.VP.QDsSTP...I.QGD...IG.VGfhensn..klersfERAILVITMSQE..A..C-..S...CndgtwrFALGGIATD...lAN..SD...PDDDIYVEIIDNGLTmLVFVH.....VLQeVSEEDIG...FRF.VASFADATsg...vvNIYESKDPGfIPKR-p....
B3PEJ4_CELJU/27-168                  ......................................................................................................................................RYFNLKPALATPIGPGD.WIF.AE.RG.TTT...D.ISS...LT.VTfpdnqs..alerelERAVLVISIEQD..E..QA..G...Gt...wrFALGGVATD...qQD..ED...PNNDIVLDIIDNGFGmLVYIH.....ALQ.DSYESVP...FGF.VASFTDATtg...vvSIYESQDPSvIITRP.....
K2K8Z1_9GAMM/8-137                   ....................................................................................................................................kh--INVHITGN-EVTGFK.FLY.ED.--.NKE...S.CEQ...VT.VD..............-GPCYLEYCIKE..N..GT..QrdyG......FKFDGVAFS....NP..FN...NVITE-AKISPDGQK.IKLTNpydvnSST.SEDYSVG...FQF.GFSFTNAPsgckaknLLLLSADPQ.VINQ-g....
A0A4Q8TZY1_9ALTE/4-117               ....................................................................................................................................pt--INFTVSVDTTTNPVT.YTI.YD.SQ.GNP...T.TDA...VV.VT..............IANTIITYTLRP..D..S-..S...D......LQFISPVIA....--..GD...PGHDLSVNISKDGQA.LTIID.....SNA.-DEEDIS...LKL.VTVPKDK-.......-VYISPDPQ.VKNRP.....
A0A7Y7DN01_9ALTE/7-121               .....................................................................................................................................y-NFTVKVNIS-EAPPV-.FAI.YD.GK.QNV...T.AQP...VK.VT..............QPNTTITYQLIN..N..T-..D...D......LVFVAPVIN....--..DD...PNHNLISKISDDGQT.IKFTD.....SDA.-NNENIC...MQLqVIQSGTPG.......KVYTSPDPQ.IRNR-k....
A0A0Q0I616_9GAMM/9-119               .....................................................................................................................................i-FITLTVTLGKNNIPI-.FSY.SN.--.---...N.DEP...II.IT..............-KKSVITYELSD..E..TE..K...G......LKFIGATFD....TP..FD...GIIDAV-TVSNDGQL.IHLLD.....LDQ.-ITGKTN...FQF.VLSNAQNS.......LMLISKDPQ.VINRE.....
A0A0M2VIL3_9GAMM/1-114               ......................................................................................................................................--MQVLVHLE-NGEPV-.FNY.QT.SG.GQP..lA.NGD...VT.VT..............-EAGTITYQLVD..H..TG..K...G......LRFIGVGFV....TP..FD...GIIDAI-TVSSDGQL.LQMLD.....MDR.-SAGTTK...FQF.VLTNATNT.......LMVLSPDPQ.VKN--dp...
Q087B2_SHEFN/13-125                  ......................................................................................................................................TFFNLTVTLE-NGEPF-.FSY.TN.HD.GTP...K.SGD...VI.IT..............-KNCTITYQLID..Q..TG..K...G......LKFVGAAFM....TP..FD...GIIDAV---STDGSL.IHLTD.....LDE.-VSGNTQ...FQF.VLSNTSNT.......LLVLSPDPE.VINRE.....
A0A0Q0HHY4_9GAMM/80-196              ....................................................................................................................................kp--IKLRVTLN-KAKEAQ.FKY.QQ.-S.SVV...C.DGN...VE.LT..............-ENTTITYSLVH..RkrTP..E...G......LRFEGAGFT....NP..FD...AHIEQV-TVSDDGQA.IYLNN.....NIE.-NLGIGK...FQF.IFSSDDSD.......LLLVSPDPQ.AIN--ik...
K4KMB4_SIMAS/15-154                  ......................................................................................................................................TQMTLTVNAD-ELPPTVcWPL.AT.NS.TVI...D.DGL...VQ.VIfpggsd..asnrkeRAILDITLVKTG..Q..AA..T...C......LTFTGAGIE....VE..SDtggGKNDVKTSLKNGGKTlRMVIA.....KDA.VGDASIN...YKF.TIAAKAKGs....kqEEYKSFDPIlIIHRP.....
F7NX03_9GAMM/10-122                  ....................................................................................................................................pv--IEVMITLDTNQEPK-.VTY.LQ.-E.GEV...C.TGN...VV.VT..............-CGEDITYRLVN..S..A-..-...G......YAFMGAGFL....TP..YD...NIIDSV-QVSADGQE.LILVD.....EDN.-VQGTTK...FQL.IFTNTTNS.......LLLLSPDPQ.VINKD.....
A0A094LNT8_9GAMM/4-125               ....................................................................................................................................yt--FDVKVIVDSNSVPV-.FNYyAP.GS.DKP...L.TSEervVT.IT..............-GPSIIFYKLIE..TefSP..A...G......LKFVGAGFK....TP..FD...GVIENV-YVSDNGDT.LVLED.....LCV.-DTGTSN...FQL.LLKTTENN.......LTLMSPDPQ.VINK-k....
#=GC seq_cons                        ........................................................................................................................................hplpVsls.sstss..Fsa.ts..t.s.s...s.sGs...ls.Vs...............pssplpYpLps..s..s...t...s......hpFsGsshs....ss..hD...s.hDhs.slossGps.ltlhD.....ssp..sstshs...Fph.Vlssssss.......hhhhSPDPp.llN+......
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