#=GF ID DUF1104
#=GF AC PF06518.15
#=GF DE Protein of unknown function (DUF1104)
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_16082 (release 10.0)
#=GF GA 25.00 25.00;
#=GF TC 25.10 25.00;
#=GF NC 24.50 24.90;
#=GF BM hmmbuild --aminoHMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 21365686
#=GF RT Crystal structure of HP0721, a novel secreted protein from
#=GF RT Helicobacter pylori.
#=GF RA Cioci G, Terradot L, Dian C, Mueller-Dieckmann C, Leonard G;
#=GF RL Proteins. 2011;79:1678-1681.
#=GF DR INTERPRO; IPR009488;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of several hypothetical proteins of unknown
#=GF CC function which appear to be found largely in Helicobacter
#=GF CC pylori. The structure of HP0721 protein consists of a bundle of
#=GF CC four alpha-helices connected by loops and stabilised by
#=GF CC hydrophobic interactions. It has been suggested that this
#=GF CC protein might represent a novel H. pylori [1].
#=GF SQ 63
#=GS Q7VFM1_HELHP/25-116 AC Q7VFM1.1
#=GS C5ZV38_9HELI/24-115 AC C5ZV38.1
#=GS A0A1I5MD65_9PROT/18-74 AC A0A1I5MD65.1
#=GS A7I0S4_CAMHC/20-110 AC A7I0S4.1
#=GS H5VDQ9_HELBI/26-103 AC H5VDQ9.1
#=GS A0A3D8I137_9HELI/23-107 AC A0A3D8I137.1
#=GS D1AYZ8_SULD5/19-72 AC D1AYZ8.1
#=GS A7GXV5_CAMC5/19-109 AC A7GXV5.1
#=GS O24943_HELPY/23-114 AC O24943.1
#=GS A0A345IY26_9PROT/21-73 AC A0A345IY26.1
#=GS A0A6G5R3P1_9PROT/19-109 AC A0A6G5R3P1.1
#=GS C6RDH6_9PROT/19-109 AC C6RDH6.1
#=GS F8KPR3_HELBC/26-103 AC F8KPR3.1
#=GS A0A128EKR3_9PROT/19-105 AC A0A128EKR3.1
#=GS A0A1P8KMZ6_9PROT/20-72 AC A0A1P8KMZ6.1
#=GS A0A3D8IJX6_9HELI/19-98 AC A0A3D8IJX6.1
#=GS A0A381DLR5_9PROT/19-114 AC A0A381DLR5.1
#=GS O25423_HELPY/22-107 AC O25423.1
#=GS V8CBE2_9HELI/24-116 AC V8CBE2.1
#=GS A0A2D3WRB5_9PROT/18-71 AC A0A2D3WRB5.1
#=GS D3UFZ4_HELM1/18-109 AC D3UFZ4.1
#=GS A0A347VIZ7_9HELI/22-111 AC A0A347VIZ7.1
#=GS H5VB29_HELBI/29-112 AC H5VB29.1
#=GS I7GTF1_9HELI/26-117 AC I7GTF1.1
#=GS A0A2A2GRU0_9HELI/23-110 AC A0A2A2GRU0.1
#=GS H5VB01_HELBI/13-105 AC H5VB01.1
#=GS V8C522_9HELI/36-127 AC V8C522.1
#=GS E7G3S9_9HELI/24-115 AC E7G3S9.1
#=GS F8KS76_HELBC/29-121 AC F8KS76.1
#=GS A0A6G5QG03_9PROT/19-109 AC A0A6G5QG03.1
#=GS A0A099U1X7_9HELI/41-132 AC A0A099U1X7.1
#=GS A7GXV6_CAMC5/30-119 AC A7GXV6.1
#=GS T1CQM4_9HELI/28-119 AC T1CQM4.1
#=GS A0A1B8J7I7_9HELI/22-113 AC A0A1B8J7I7.1
#=GS A0A363D1G4_9PROT/21-76 AC A0A363D1G4.1
#=GS A0A2W6MTS5_9HELI/23-114 AC A0A2W6MTS5.1
#=GS Q7MSV3_WOLSU/22-113 AC Q7MSV3.1
#=GS E7G3S8_9HELI/11-102 AC E7G3S8.1
#=GS V8CHA5_9HELI/25-116 AC V8CHA5.1
#=GS A0A2D3W7M5_9PROT/20-80 AC A0A2D3W7M5.1
#=GS A0A5C8KXW6_9PROT/22-113 AC A0A5C8KXW6.1
#=GS A0A345J607_9PROT/20-71 AC A0A345J607.1
#=GS F8KTN8_HELBC/22-114 AC F8KTN8.1
#=GS A0A2D3W278_9PROT/19-73 AC A0A2D3W278.1
#=GS A0A3D8J7J5_9HELI/18-109 AC A0A3D8J7J5.1
#=GS A0A6G5R4E7_9PROT/20-110 AC A0A6G5R4E7.1
#=GS A0A1G5Q9L1_9GAMM/26-86 AC A0A1G5Q9L1.1
#=GS A0A329ZTH0_9HELI/22-113 AC A0A329ZTH0.1
#=GS F8KTN9_HELBC/26-117 AC F8KTN9.1
#=GS A0A268TE19_9HELI/22-113 AC A0A268TE19.1
#=GS A0A2P8R3G2_9PROT/19-109 AC A0A2P8R3G2.1
#=GS A0A3D8HW48_9HELI/24-116 AC A0A3D8HW48.1
#=GS I2K988_9PROT/18-77 AC I2K988.1
#=GS H5VB00_HELBI/1-60 AC H5VB00.1
#=GS A0A3D8HWC0_9HELI/20-108 AC A0A3D8HWC0.1
#=GS A0A4Q0Y2Z8_9PROT/21-73 AC A0A4Q0Y2Z8.1
#=GS A0A1B8J827_9HELI/23-115 AC A0A1B8J827.1
#=GS A0A370DPX8_9GAMM/25-90 AC A0A370DPX8.1
#=GS C8PES6_9PROT/19-107 AC C8PES6.1
#=GS I2K903_9PROT/18-121 AC I2K903.1
#=GS A0A7S7M0D5_9PROT/23-74 AC A0A7S7M0D5.1
#=GS D5V1Y3_ARCNC/21-75 AC D5V1Y3.1
#=GS O25421_HELPY/43-108 AC O25421.1
Q7VFM1_HELHP/25-116 .............DFSSRSDAELVKLS.G.I.VK.VEEFVD...YELEVAKRLKSKTEKEAKE.FKSKLKEQYEKATEKLSVKQYREYKKATREAMKKHLEKMSSKERKESGL..........................................................
C5ZV38_9HELI/24-115 .............DFSKKSNDELINLS.G.K.VT.PKDYPD...YKMEIHKRTQGMTLQEARN.FREQLRDKRQSVYDQMTLKEYREYRDAIAKETAKRIDSMSEKEAYESGL..........................................................
A0A1I5MD65_9PROT/18-74 .............DYSDRSTQELIASL.A.Y.EK.STNIPI...ILHELKKRELTMSPKEKKE.YKKVLKKLKDES-------------------------------------qk........................................................
A7I0S4_CAMHC/20-110 .............DFSGKSSDELIKSL.N.T.KD.PVVFAD...AMFELRKRVG----EQNKIiFK--MRSAMCEQMSSKTPEERFKFKGEVHKAMSDKIEKLSSGEKAE---ffenmgf...................................................
H5VDQ9_HELBI/26-103 ............s-YQNTSNADLIKLA.G.K.VA.PEKKPD...YAMEIYKRAEKMNPKQRKE.FYREVIAIADKSVANAVIKNISKRMEAL---------------------sawqsnn...................................................
A0A3D8I137_9HELI/23-107 .............DFSKKTNDELVKLS.G.I.VD.PKDVLD...YKKEIENRINNMTGNDAKV.FKEQLRTQKEKVYGEMKVRDLKQRQEAIFNAIKEQCS------------kdpts.....................................................
D1AYZ8_SULD5/19-72 .............DFSEMSTEELIALL.G.Y.VE.PQKEER...FLKELTRREESMSEEQKAL.YEAWKRQK-----------------------------------------see.......................................................
A7GXV5_CAMC5/19-109 ..........sle---KSTNEELYAMM.A.N.AD.AKTLSD...IAFEIDKRVGELK-AQIKD.TKRGFKSEMRKKLEAMSAADRYKFMQDFRTGYNEKVSALSVKDA-----drldi.....................................................
O24943_HELPY/23-114 .............DFKSMDDKQLLEQA.G.K.VA.PSEVPE...FRAEVNKRLAVMKEEDRKN.YKADFKKAMDKNLASLSQEDRNKRKKEILEAIANKKKTMTMKEYREEGL..........................................................
A0A345IY26_9PROT/21-73 .............NYSEMSTQELISIM.G.Y.VD.KKNQTK...FENELKSRISTMTPKEKTM.YQNNLKKM-----------------------------------------kk........................................................
A0A6G5R3P1_9PROT/19-109 ...........si--SDSSNEQLNSMV.A.G.AD.AKTLSE...ISFEIHKRAGKL-DSQIED.IRGDFREQMRQKMSAMSPDERVKFMQEYRAMMRDKIDALSVKEAREMGF..........................................................
C6RDH6_9PROT/19-109 .........slen----STNDELYKMV.A.N.AD.AKTLSE...VAFEIDKRAGKLKF-EAKE.AKRGLKTEIRKKFEAMSIADRERFMREFRNGYNAQVGALSVAEAKK---ldi.......................................................
F8KPR3_HELBC/26-103 ............s-YQNTSNADLIKLA.G.K.VA.PEKKPD...YAMEIYKRAEKMNPKQRKE.FYREVIAIADKSVANAVIKNISKRMEAL---------------------sawqsnn...................................................
A0A128EKR3_9PROT/19-105 sslsdkvldvkng--------------.-.-.-D.AQSYAN...AAFEIRKEASMMDKEIKK-.ACESFHNVMRTQMSSLSKDEAVKFKDEFHKALANKIASLKGDEK-----lnfdf.....................................................
A0A1P8KMZ6_9PROT/20-72 .............DYSEMSTQELIAIM.G.Y.VK.DKNKKQ...FVRELNSRTSTMSEKEKQN.YKNNLP-------------------------------------------klnk......................................................
A0A3D8IJX6_9HELI/19-98 .............DYSSKSDNDLINLA.G.T.IE.PKDIPS...YFDEIEKRVNEMTMKDARE.FKMKVKEQENKVYDKMKVKDFKARQKAIMEVMGK---------------nnk.......................................................
A0A381DLR5_9PROT/19-114 .............DLSDKMGSEIISGI.N.S.SD.TSSLAD...AAFEIRKRANNNYNEISKM.CQ-SFHNIMKAEMMSKNPADRQAFRDDFHKKLSERINTLSSSQK-----adfdfaickk................................................
O25423_HELPY/22-107 .............DFSKTSDEDLAKMA.G.V.VA.PQDIVD...YTKELKKRMEKMPEDKRKA.FHKQLHEYATKNTDKMTVADFEARQKAVKEALKK---------------gnmedmddd.................................................
V8CBE2_9HELI/24-116 .............DYSKNSDDELIKLNnG.K.LK.AADAAD...LKLEVIKRANKLEGEAKKA.FLDKVKAAYDKATENFKVKDFRAYEESVRKEFKAKIDALSEEAKKEFGI..........................................................
A0A2D3WRB5_9PROT/18-71 .............DFSQMSTEQLMKMR.G.N.VP.LAERSA...FQQEMQKRMQNMSPQERQA.YMQ----------------------------------------------snngmmrg..................................................
D3UFZ4_HELM1/18-109 .............DFSKMSNDDLAKMA.G.T.VD.AKDFAD...YHMELHKRMHGMSKDQMKD.FAKEIREYREKNTDNMTLKEYREQREKIKEALEQKVKGMSKEECKKSGI..........................................................
A0A347VIZ7_9HELI/22-111 .............DYSKKSNDELVKLH.G.S.VKnASDAAD...LKIEIKKRIDKMDEKVRKD.FIDKLKASYEKNTENMSVKEFRAYESSVKKELKAKMEKLG---------ikhpeg....................................................
H5VB29_HELBI/29-112 ............e-YQAKPDQEMLDLA.G.K.IE.ARKVIE...YLSEMKNRYNKMTPKHKAD.FQKQFQDNLAKNLAKLKPSERKQRLATIKKDFSRKG-------------skyqp.....................................................
I7GTF1_9HELI/26-117 .............DFSKKSDKELISLS.G.V.VK.VEEFAD...YELEIAKRMKAKSEKEAKD.FREKLKAQYEKATENMSVKEYREYKKATHEAMKKRVENMSEKELKESGL..........................................................
A0A2A2GRU0_9HELI/23-110 .............DFAKKSNKDLINLA.G.K.VK.PKDVPE...YRLEIAKRIEDMSVKEARE.FEESIREQAQKVYDGMKVKEFRDYRHEAHKAVEEFCRK-----------nkeeckl...................................................
H5VB01_HELBI/13-105 .............DYSSLSGPELIKLA.G.K.VP.AEDALD...LRAAVHKHVESLKTAKAKSsFKWKFKQAAEAHFKKMKKKDFVAMREEVRKEFEEATKEHSPDELKEMGL..........................................................
V8C522_9HELI/36-127 .............DFSAKSDSELIKLA.G.S.IA.PSDEPD...FAIEVNKRVNAKPYAEAKD.FKRAIKYARKQGFSKLSVEQARKRKIESCKAFQARTDSMTGAQIREAGL..........................................................
E7G3S9_9HELI/24-115 .............DFSKLSNKDLVKMA.G.K.VD.ASQELE...YHMEVHKRLKKLKGVKARE.FHRQVERATVAHLSKMSKKKFMALREEVAGKLEEMKKEHSPEELKSMGL..........................................................
F8KS76_HELBC/29-121 ............e-YQAKPDQEMLDLA.G.K.IE.ARKVIE...YLSEMKNRYNKMTPKHKAD.FQKQFQDNLAKNLAKLKPEERKQRLATIKKALAAREANI----------nhlreevdeey...............................................
A0A6G5QG03_9PROT/19-109 .............SFEKNTNDELVAMI.S.G.AD.AKMMSE...ISFELHKRAGVLSEQANKI.-RADFRDKMRSKISTLKEGERRQFMSEFHKNYDKKIDELSVKEAKNFGF..........................................................
A0A099U1X7_9HELI/41-132 ............k-FKNDNSEESIKEA.I.K.TA.VDDAVE...FSLKIKKRANEMSEDVRKN.FISEIKARYKENTKNISLDKLKKYEQETLKALKNKIDNMSDSAKQEYGI..........................................................
A7GXV6_CAMC5/30-119 ..........fak----VKEAGFGKMI.T.R.SD.AKTLAD...MAFEIDKRFGKLK-AQANT.TKAAFEAKMQNRLEALTKEQRDDFVQGFNARYNERVCALSIKEAETLG-i.........................................................
T1CQM4_9HELI/28-119 .............DFSKKSDKDFIALA.G.A.VS.ATDEPD...YIIEANKRINAKLYNEAKE.FKLAIHKQRAENLKKLSPELAKQRAIDVCKAIQAKTDTMSGKQIRES--nl........................................................
A0A1B8J7I7_9HELI/22-113 .............DFSKKSDKELISLA.A.N.IS.AQDEPD...FIMEVEKRAKSKLYEEAKS.FKKAVKDARHEARAKLTPEQAQKRAIEVCKATQAKTDKMNGKEIRESGL..........................................................
A0A363D1G4_9PROT/21-76 .............DYSEMSTQELIAII.G.Y.VK.DENKAQ...FIKELNLRIPTMTQDEKVQ.FEQNIQELKQN--------------------------------------en........................................................
A0A2W6MTS5_9HELI/23-114 .............DFSKVNNQQLIDMA.G.T.VK.PKDYPD...YRIEVNKRIQEMKVSEARE.FREKMRLQARSVYDKMSVAEHRAYRDSIREEMDKKIQGMSEREFRESGL..........................................................
Q7MSV3_WOLSU/22-113 .............DFSKKSNAELQSMA.G.S.VA.PKEVLD...FKSEIHKRTQKMTVAEART.FHQGMQKAMQEKMSKMTMEEAQKYHNEVRLEVQKQLDSMTVEEAQKRGF..........................................................
E7G3S8_9HELI/11-102 ............p-FESKSDKELIDMA.G.K.VV.PNQVPD...YKMELYKRTKKMKPEQRKK.FYEKVMASADKNTANMTMEDFGKRMEAIHAAMKARIAKMTRAQFKASGL..........................................................
V8CHA5_9HELI/25-116 .............DFSKLSDEALVKKV.A.S.LS.AQDEPD...FVMEVHKRLKAKDEPQAKA.FRESIHQARKAAHDKLSKEQRQNRAVEVCKAMQKKTDSMSGKEIREAGL..........................................................
A0A2D3W7M5_9PROT/20-80 .............DFSEMSTEELIALI.G.Y.VD.AEKEEP...FYRELEKRVSQMDEAQKTL.YENDQSQRR-KDA------------------------------------qsqtpt....................................................
A0A5C8KXW6_9PROT/22-113 .............DFSKKSDEEILNLA.K.S.VK.SEDQAD...LIIEAKKRMNEMKYKDAIN.FHSKFQTNLHENISKLSPKERQQRKAIVQKDMMELTDKMSGKEIRE---lnl.......................................................
A0A345J607_9PROT/20-71 .............NFSEMSNQELIAIM.G.Y.VK.SNEKKA...FEKELQSRVSTMNDKEKKA.YIKNL--------------------------------------------pklq......................................................
F8KTN8_HELBC/22-114 .............DYSSLSGPELIKLA.G.K.VP.AEDALE...LRAAVHKHVESLKTAKAKNsFKWKFKQAAEAHFKKMKKKDFVAMREEVRKEFEEATKEHSPDELKEMGL..........................................................
A0A2D3W278_9PROT/19-73 .............DYSAMSAAELSAMR.G.T.VP.TEDRAA...FQAAMQSKMQALSQEERQS.LSQS---------------------------------------------qrantngt..................................................
A0A3D8J7J5_9HELI/18-109 .............DFSKMSNEELIGIA.G.K.VD.VKEVAD...YQIELHKRIKEMKKADAKE.FHKKLKEATEKNTENMTLKEFKERMEAIKQAVGERIKTMSKEECKKSGL..........................................................
A0A6G5R4E7_9PROT/20-110 ............k-FDKAQSCGFAKMI.K.N.AD.AKTLGE...ISFEIDKRAAKLRVE-AEA.SKQDFKSEFDKKIASISQDEQVKFKEKFIASYNEKVLNLSVKEANE---lal.......................................................
A0A1G5Q9L1_9GAMM/26-86 .............DFGGKTNEELMRMN.PqQ.MS.ADEREQ...FRTEMRQRMQNMDSAEQQQ.FRNEMRSQ-----------------------------------------sgggqgnkq.................................................
A0A329ZTH0_9HELI/22-113 .............DFSKTSLADLQNMS.G.K.VK.PQDALD...YRMELHKRMEEMTVKEARE.FRQQLREKARANHDKMTKAELQKYREDVRTQMQTQLDSMLVKDARAKG-v.........................................................
F8KTN9_HELBC/26-117 .............SFKDKSNQELIEMA.G.K.VV.PNEVPD...YQMELFKRMKGMSAEQKKK.FHEQLKEAADKNTENMTMEEFEKRREAIRAAIKARIAKMTRAEYKNSGL..........................................................
A0A268TE19_9HELI/22-113 .............DFSKKSNDELIKIA.G.T.VA.PKDVPD...YRIELHKRFKTMKKEDAKV.FHQELETSMKQNTATMSVKDFRARKQAIQKAIDEKLKGMSKEQIKESGL..........................................................
A0A2P8R3G2_9PROT/19-109 ...........si--SDSSNTELYSMV.K.D.AD.AKTLSD...VSFEVHKRAGKL-NSQAKE.IKQGFKDEMHKKISSMSDEDRAKFMQEYKKNMNEKIDSLTVKEAREMGF..........................................................
A0A3D8HW48_9HELI/24-116 .............DYSKKSESELIKLN.G.TlKK.VEDAVD...LRLEIKKRIAKMDDKQKPD.FVKKLKDSYEKNTGDMKVKDLRKLESDTKEAFAKRIQKLSDAEKKELGL..........................................................
I2K988_9PROT/18-77 .............DFSHMSTEDMMHMR.G.S.IP.MEQRDD...FRKEMQKRMQSMTQEERQK.YGMQGKG------------------------------------------mmsgqgmmgm................................................
H5VB00_HELBI/1-60 .............--------------.-.-.--.------...--------MKGMNAEQKKK.FHDQLKEAADKNTENMTMEEFEKRREAIRAAIKARIAKMTRAEYKNSGL..........................................................
A0A3D8HWC0_9HELI/20-108 .............DYSKKSDKELISIA.G.S.ME.PKDVPS...YFQEIEKRVEEMTLKEARE.FKEKIKAQEQKVFDSMKVKDFKARKKAIHEEFEKLCKD-----------kkegckap..................................................
A0A4Q0Y2Z8_9PROT/21-73 .............DFSEMSTQELIEIM.G.Y.VQ.KKNLNR...FNKELKSRVPTMNEKEKAK.YKENLKKL-----------------------------------------kk........................................................
A0A1B8J827_9HELI/23-115 .............DYSKQSDSDLIKLNnG.K.LK.AADAAD...LKLEIMKRASKLEGDAKKD.FFEKLKASYEKATDSWKAKDLRAYEAEVKKAFKEKVQSLSDEAKAELGL..........................................................
A0A370DPX8_9GAMM/25-90 .............DYADMSNEELVQMR.S.Q.VR.EQSYEDregYRTEMQNRMQSMDSEERSL.FR-QMNET-----------------------------------------geqgegsgkmnry.............................................
C8PES6_9PROT/19-107 .............DFQNSTPEQINASV.A.S.AD.AKSLSE...AAFEIDKRAGEL-RAQARD.LKRGFKTEFKKKLDAMSVEDREKFLDEFRKNYNAQAGKLSVEQ------adrl......................................................
I2K903_9PROT/18-121 .............DFSNMSTEEMMNMR.G.S.VP.VDDRPA...FQQEMQKRMQSMTPEERQK.YMR----------------------------------------------tngmgkgmgmtskrncckhimqptfeeydlnndgkitqseleearakrmsqkakegkm
A0A7S7M0D5_9PROT/23-74 .............NFSEMSTQELISIM.G.Y.VK.KENVQE...FKKELQSRVSSMSQSEKKT.YEKNIKK------------------------------------------ik........................................................
D5V1Y3_ARCNC/21-75 .............DYSEMSTQELIEII.G.F.VK.KENIAK...FEKELKSRVSTMSVKEKNQ.YIINMKKSKDK--------------------------------------r.........................................................
O25421_HELPY/43-108 .............DFSQLKNEELLKLA.G.T.LP.SNEAID...YRMEVSKRLKTLNAEDAKK.FRANFSRIARKNLSKMSE-------------------------------gfqkn.....................................................
#=GC seq_cons .............DaSchSspELlphs.G.p.lc.scchs-...aphElcKRhppMs.cct+p.F+pph+pthppthtphp.cchtthhtthttthttthtth....................................................................
//
