#=GF ID   DUF1281
#=GF AC   PF06924.15
#=GF DE   Protein of unknown function (DUF1281)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_14730 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   31.40 36.10;
#=GF NC   24.80 19.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR009694;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several hypothetical enterobacterial
#=GF CC   proteins of around 170 residues in length. Members of this
#=GF CC   family are found in Escherichia coli, Salmonella typhimurium and
#=GF CC   Shigella species. The function of this family is unknown.
#=GF SQ   36
#=GS A0A0M2KH69_9GAMM/30-207  AC A0A0M2KH69.1
#=GS Q7N7I7_PHOLL/30-208      AC Q7N7I7.1
#=GS W1J6Z0_9GAMM/30-74       AC W1J6Z0.1
#=GS A0A845SH86_9GAMM/30-207  AC A0A845SH86.1
#=GS Q7N7T0_PHOLL/30-208      AC Q7N7T0.1
#=GS A0A433SAP7_9BURK/30-206  AC A0A433SAP7.1
#=GS A0A2D0KKQ3_9GAMM/30-206  AC A0A2D0KKQ3.1
#=GS D8MJH7_ERWBE/30-207      AC D8MJH7.1
#=GS D3VA62_XENNA/30-206      AC D3VA62.1
#=GS A0A6G9IEM2_9GAMM/32-211  AC A0A6G9IEM2.1
#=GS A0A6G9IEX0_9GAMM/34-208  AC A0A6G9IEX0.1
#=GS C5BDJ0_EDWI9/30-207      AC C5BDJ0.1
#=GS A0A2S4MRM3_SHIFL/45-222  AC A0A2S4MRM3.1
#=GS A0A6M8UIC1_9GAMM/30-208  AC A0A6M8UIC1.1
#=GS A0A240AMJ8_SERFI/30-208  AC A0A240AMJ8.1
#=GS D3V0P1_XENBS/30-206      AC D3V0P1.1
#=GS A0A2I5TNN1_SERS3/30-207  AC A0A2I5TNN1.1
#=GS A0A433SFB7_9BURK/30-219  AC A0A433SFB7.1
#=GS O82895_ECO57/22-199      AC O82895.1
#=GS A0A2D0KNN1_9GAMM/30-206  AC A0A2D0KNN1.1
#=GS W1INY8_9GAMM/30-206      AC W1INY8.1
#=GS W1J1L6_9GAMM/30-206      AC W1J1L6.1
#=GS Q327B9_SHIDS/30-127      AC Q327B9.1
#=GS T0PC52_PHOTE/30-208      AC T0PC52.1
#=GS W1J6N6_9GAMM/30-206      AC W1J6N6.1
#=GS A0A6G9IE88_9GAMM/30-217  AC A0A6G9IE88.1
#=GS A0A6G9ID24_9GAMM/34-211  AC A0A6G9ID24.1
#=GS B4EXF1_PROMH/32-207      AC B4EXF1.1
#=GS D3V042_XENBS/30-206      AC D3V042.1
#=GS A0A014NTS2_9GAMM/30-207  AC A0A014NTS2.1
#=GS A0A068QP89_9GAMM/30-206  AC A0A068QP89.1
#=GS A0A376C478_CITKO/30-207  AC A0A376C478.1
#=GS A0A085AA42_9ENTR/30-207  AC A0A085AA42.1
#=GS W1J5X0_9GAMM/2-116       AC W1J5X0.1
#=GS A0A6I4VDD5_9GAMM/30-207  AC A0A6I4VDD5.1
#=GS D3V9J1_XENNA/30-206      AC D3V9J1.1
A0A0M2KH69_9GAMM/30-207             ......t-PRYR..HAILQSIQLFLTGCAGILK..PVRTV..SYMP.FQGL.....V...R.HGV.GQSTAANLAFEQWLELLQKDVALDTETIRRIDRLYH...QSGLGALKWENI-PQVSRD.IM.A.MlMKRQYADWFGLAGMNDEPDAAACWERL..RE.Y.P..E..RSQP.CDMLMVIPTRLATELNG-SGG....LL...AGISTTVSFYSRIYGMEWP.................
Q7N7I7_PHOLL/30-208                 .......IPYYG..QAIHQSIKLFVAGCVGLLQ..PTETT..DFLL.YPAL.....V...A.KGT.GGDSPENRAFEQWLALLKENVALDEVTSQQIDRLYQ...QSGLAERKWETLLPTAQKT.IM.A.L.FNQKSCDWFGLVDWNGERDTEMLWSHL..DD.R.L..T..ETVP.CDLFLLIPTHLASEINGFCGG....LL...RDHETTHELYIRLYGMAQP.................
W1J6Z0_9GAMM/30-74                  ......a-PRYR..QAVLQSLRLFLAGCAGILK..PTKPQ..TYTP.YPVL.....V...R.GT-.------------------------------------...-------------------.--.-.-.---------------------------..--.-.-..-..----.---------------------....--...-------------------asgf.............
A0A845SH86_9GAMM/30-207             .......IPQYR..HAVQQSIRLFLAGAAGILK..PVKPM..EYRP.FPGL.....V...S.HGT.GSAVAQNQAFQYWLELLQQDPAFNAEVIRQIDRIYL...QSGIASVKWESLPVDARQV.MT.Q.L.MVRQYADWFGVANWSYYIDGSACWERL..GI.M.P..E..CACN.CDMLMVLPSRLAAELNG-NGR....LL...AGIPTTGSLYSQLYGTE--wp...............
Q7N7T0_PHOLL/30-208                 .......IPYYG..QAIHQSIKLFVAGCAGLLQ..PTETI..DYPL.YPAL.....V...A.GGV.GEMSPENWAFEQWLALLKENVALDEVTSQQIDRLYQ...QSGLAERKWETLLPTAQKT.IM.A.L.FNQKSCDWFGLVDWNGERDTEMLWSHL..DD.R.L..T..ETVP.CDLFLLIPTRLASEINGFYGG....LL...KDHETTHELYFRLYGMTRP.................
A0A433SAP7_9BURK/30-206             ......r-PIHQ..EAIQKSRKLFVAGCAGLLK..TIKPV..GFQI.YPQL.....V...Q.AGI.GANTPQNKAFTDWLILLKTEPDLNTSISKEICLLYE...ESGLDFRSWQTLSHTEQNI.AS.T.L.FSQKSGDWFDLPFTEKEITAQQCWQML..DE.-.M..P..ISFG.FDMRFLIPTQLFAEINGTSGN....L-...FDYQSTFHLYHDLYET---rwp..............
A0A2D0KKQ3_9GAMM/30-206             ......f-PRYR..QAVLQSLRLFLAGCAGILK..PTKPL..TYTP.YPEL.....V...R.GTA.A-PTAQNLAFEQWLALLQDNVLLTTENMKRIDSIYR...QSGLSLLRWETIPASARDM.IA.R.L.LTRQYTDWFGVVGWSDNLDISACWEKL..SV.Y.P..T..SAQP.CDMLMIRPTRLATEINGN-SG....LL...KGMTTTAQCYDEHYGLE--wp...............
D8MJH7_ERWBE/30-207                 .......VPLYR..HAVMRSIKLFLAGCGGLLR..PVKTE..SFTP.FPGL.....M...Q.SGT.GLGTPANMAFDQWLGLLRRDVPLDGEHLRTIERIYH...QSGIDAIRWESIPEVSRRH.IA.R.L.IEERYADWFGVATLSREIVPGQCWERL..SH.L.P..E..RAQP.CDMLQIIPSRLAAELNGT-GG....LL...AGMSTASSLYCRQYGMEWP.................
D3VA62_XENNA/30-206                 .......VPRYR..QAVLQSLRLFLAGCAGILK..PTKPQ..TYTP.YPAL.....V...R.GTA.V-PTAQYLAFEQWLLLLQNNVPLNTDNIKRIDNLYR...QSGLSLMHWDKVPEAARDI.IA.R.L.LTRQYTDWFGMVGWSDTPDIGACWDKL..NA.Y.P..Q..AAQP.CDMLMIMSTNLATEINGN-ST....LL...KGIATTAQFYGEQYGMEWP.................
A0A6G9IEM2_9GAMM/32-211             ......d-PYYAflFAIKRSIKIYVAGCAGILK..PVTTI..YNAP.NTEI.....I...S.HGI.GEITPENTAFSYWLSFLISDCPLDSIYSGMIGDLYY...ETGLLNLAWEFM-PKEQQTiIH.E.L.FKRNSFSWFKLNTPISLEDAGCLWYSL..DD.P.V..C..QFVP.FDLRYFMPTTLAKEILSESSC....DI...E-NNPSFQRYFEHYGV---eqs..............
A0A6G9IEX0_9GAMM/34-208             ....ypa---HK..IALNQSLKFILSGFAGIVK..NLEIP..ER--.QEAL.....S...S.EQKkAEMA-GSLAYSSWLNLFLINQPLTSATCVKINELYQ...QSKLSQIKWVDLTVNQKEL.IE.F.Y.LRTGSSDWFGLSKVLASSEVANIWDNI..LE.D.I..P..MMSK.LDLRSIIPTSIQSEINANL-N....LF...NEIPSRHDFYIDQYG----tei..............
C5BDJ0_EDWI9/30-207                 ......t-PRYR..HAILQSIQLFLAGCAGILK..PVRTV..SYIP.FQGL.....V...R.HGI.GQSTAANLAFEQWLELLQKDVALDTETIRRIDRLYH...QSGLGALKWEN-IPLASRD.IM.AtL.MKRQYADWFGLAGMNDEPDAAACWERL..RE.Y.P..E..RSQP.CDMLMVIPTRLATELNG-SGG....LL...AGISTTVSFYSHIYGMEWP.................
A0A2S4MRM3_SHIFL/45-222             ......t-PLYR..RATNEGIQLFLAGSAGLLQ..ITENI..RSEQ.CPGV.....T...A.AGR.GAVSTENIAFTRWLTHLQNGVLLDEQNCLMLHELWL...QSGTGQRRWEGLPDDARET.IT.V.H.FTAKRGDWC---DIWGNEDVSVWWNRL..CD.N.V..VpeKTMP.FDLLTVLPTRLDVEVNGFNGG....VL...NGVPSAYHWYTERYGVKW-p................
A0A6M8UIC1_9GAMM/30-208             ......y-PAYA..RAEAEGIQLLMAGCAGLLR..PVSAT..GYAP.YPAL.....T...G.EGP.GDDTPQNRAFTQWLQLLNDQTALTEAACATLHELWL...ASGISGRTWDTLTGVQQEY.IR.A.L.WEQKRHDWSGAFCINGT---EESWNRLcrGE.G.Y..T..RRAPlLDMQLLLPTRLDVEINGFNGG....LL...DGVPSGYSWYVSHYGVKW-p................
A0A240AMJ8_SERFI/30-208             .......VPDYR..HAIQQSCRLFLAGCAGILK..PATTKpgVYVP.YPDL.....L...S.H-P.GIASPQNLAFEHWFGLLKADIPLTAENIRLIERLYR...QSGIDAVKWENIPNVAKAR.MA.D.V.LSRQYADWFGLVGVSPDIDAGICWERL..GV.M.P..E..YTVP.CDMLMLIPTRLASELNG-SGA....LL...REVPATADLYGRQYGVE--wp...............
D3V0P1_XENBS/30-206                 .......VPRYR..QAVLQSLRLFLAGCAGILK..PTKPQ..TYTP.YPAL.....V...R.GTA.V-PTAQHLAFEQWLLLLQNNVPLNNDNIKRIDNLYR...QSGLSLMQWDKVPEAARDI.IA.R.L.LTRQYIDWFGMVGWSDTPDIGACWDKL..NV.Y.P..Q..AAQP.CDMLMMMSTNLATEINGN-SG....LL...KGIPTTAQFYEEQYGLE--wp...............
A0A2I5TNN1_SERS3/30-207             .......VPLYR..HAVQQSIQLFLAGAAGILK..PAKNV..EYLP.FPGL.....V...S.HGS.GPAIASNLAFQHWLELLQKDAVLNPDTVRQIDRIWT...QSGLSAVRWETIPLAARQI.MT.P.L.MTRQYVDWFGVATWSSHIDGGACWEKL..GK.R.P..D..RACH.CDMLMIIPSRLAAELNG-NGH....LL...TGMSSTGSLYSRVHGMEWP.................
A0A433SFB7_9BURK/30-219             ......c-PYYF..NAVNRSIKFFIVGIAGIAQiiPSELM.lEDNT.FDAIsstfmV...L.HSH.ITPTPMNIAFTQWFNLLRTNPDLSYENSTRIIQLYE...QSGLTSFSLDILAPEQKQV.IH.E.I.MAAQSYDWLGVFGYAPDKLNE-CWEKL..DE.T.K..T..STQP.FDMRQLIAPKLIPELVGFNGHwfdkVF...TNSKTSYHEYIDTYGVK--wp...............
O82895_ECO57/22-199                 ......t-PLYR..RATNEGIQLFLAGSAGLLQ..TTEDV..RFEP.CPGL.....T...A.AGR.GVVSPENIAFTRWLTHLQDGVLLDEQNCLMLHELWL...QSGTGRRRWEELPDDARES.IT.A.L.FTPKRGDWCDI--W-SNEDVSVWWNRL..CD.N.VlpE..KTMP.FDLLTVLSTRLDVEVNGFNGG....VL...NGVPSAYHWYTEQYGVKW-p................
A0A2D0KNN1_9GAMM/30-206             ......f-PRYR..QAVLQSLRLFLAGCAGILK..STKPL..TYTP.YPEL.....V...R.GTA.A-PTAQNLAFEQWLALLQDNVLLTTENMKRIDSIYR...QSGLSLLRWETVPASARDI.IT.H.L.LTRQYTDWFGVVSWSDNLDIGVCWEKL..SV.Y.P..T..SAQP.CDMLMIRPTRLATEINGN-SG....LL...KGMASTVQFYDEHYGLE--wp...............
W1INY8_9GAMM/30-206                 ......l-PGYR..QAVLQSLRLFLAGCAGIFK..PTKPQ..TYTP.YPEL.....I...R.GTA.A-PAAHNLAFEQWLKLLQDNVPLNNNNIKLIDSLYR...QSAISLMRWDSVPEPARVV.IA.R.L.LTRQYADWFGMAGWSEAINIGECWDRL..ND.S.P..E..STQP.CDMLMIMPARLAIEINGN-SG....LL...KGIATTAQFYTQQYGFE--wp...............
W1J1L6_9GAMM/30-206                 .......IPRYR..QAVLQSLRLFLAGCAGILK..PTKPQ..TYIP.YPAL.....V...R.GTA.AP-TAQHLAFEQWLLLLQNNVPLNTDNIKRIDNLYR...QSGLSLMSWDKVPEAARDV.IA.R.L.LTRQYTDWFGMVGWSDTLDIGACWDRL..EV.Y.P..Q..AAQP.CDMLMIMATSLATEINGN-ST....LL...KGISTTAQFYEELYGLEW-p................
Q327B9_SHIDS/30-127                 ......t-PLYR..RATNEGIQLFLAGSAGFLQ..ITENI..RSEQ.CPGV.....T...A.AGR.GAVSTENIAFTRWLTHLQNGVLLDEQNCLMLHELWL...QSGTGQRRWV---------.--.-.-.---------------------------..--.-.-..-..----.---------------------....--...-------------------rctgnsghyh.......
T0PC52_PHOTE/30-208                 .......MPYYG..QAIHQSIKLFVAGCAGLLQ..PIKTT..DYLL.YSAL.....V...A.QGT.GGGTPENRAFEHWLALLKENVALDEVTSQQIDRLYQ...QSGLAARKWETLLPAEQET.IR.A.L.FNQKSRDWFGLLTWNGERDAEMLWSHL..DD.R.L..T..ETVP.GDLFLLIPTHLTSEVNGSCGR....LL...KDHETTRELYFRLYGMIQP.................
W1J6N6_9GAMM/30-206                 .......VPRYR..QAVLQSLRLFLAGCAGILK..PTKPQ..TYTP.YPAL.....V...R.GTA.AP-TAQHLAFEQWLLLLQNNVPLNTDNIKRIDNLYR...QSGLSLMSWDKV-PEAARD.IM.AhL.LTRQYTDWFGVVGWSDTPDIGACWDRL..DV.Y.P..Q..AAQP.CDMLMIMSTNLSTEINGN-SG....LL...KGIPTTAQFYEAQYGLE--wp...............
A0A6G9IE88_9GAMM/30-217             ....ppn---HL..RAVKQSIKFLLAGHVDLVQ..PTKKF..ETPApYPYL.....SpyrE.HVL.SNYTKEDIAYTKWLRFFNQNASLSPRNIDSINRWYQ...ESQLAKVRWYSLSAVQREM.IW.L.V.LDGQYLYWSYLMQESRYLTPKEFWDAL..DA.P.P..-..SPYR.LDFRVIKPSRLNCHINGTDGK....LLiapKEDEF--------------rfslvdrylklysnslp
A0A6G9ID24_9GAMM/34-211             ......q-PFHL..RAIRHSIKLFTAGCAGILQ..PVTDM..AYAP.YPDL.....V...K.FGQ.GENNKANEAFSVWLKCLEADIPLSSIQSERICSLYE...DTELTNLNWFNLSREQIAI.IV.H.L.FNQNGDYWFGHSGQITEDDAIFYWNNY..LD.I.L..P..LQAD.FDLRYIVPTSLASELNGH-NK....LL...KGIESIRDFYIKTYCVDS-p................
B4EXF1_PROMH/32-207                 .......IPAWQ..TAIAQSLHLLLAGCAGILK..PVRPL..SFPP.LPEL.....T...SyGAT.GPVSPGNTAFTHWVDLLMTAPDLTPSCCQQIHQWYQmwlSEGGAYHSWDSLTATQKAR.LS.P.L.LSGSSFDWLNRFTGEDESRVATAWEDI..QYlRsT..G..EAIP.MDMRTLLPTSLAAELHGFNGC....LW...KTPEV--------------iwrqa............
D3V042_XENBS/30-206                 .......VPRYR..QAVLQSLRLFLAGCAGILK..PTKPQ..TYTP.YPAL.....V...R.GTA.V-PTAQHLAFEQWLLLLQNNVPLNNDNIKRIDNLYR...QSGLSLMSWDKVPEAARDI.IA.R.L.LTRQYTDWFGMVGWSDTPDIGACWDKL..NA.Y.P..Q..AAQP.CDMLMMMSTNLATEINGN-ST....LL...KGIATTAQFYEEQYGLE--wp...............
A0A014NTS2_9GAMM/30-207             ......t-PLYR..HAIRRGIKLFLAGCAGILK..PVKFT..EYVP.YPML.....T...A.SGT.GTHIAPNQAFQHFLELLERDAWLDGTTLSRLEKIWQ...MSDIGSLKWESIPLSARQI.MT.Q.L.MAVHGADWFGMAGAGGQFDPQERWEWL..NA.L.P..E..TTCH.CDMLMVMPSRLGTELTGN-SG....LF...KGLSSTSELYVQLYGMEF-p................
A0A068QP89_9GAMM/30-206             ......l-PGYR..QAVLQSRRLFLAGCAGIFK..PTKPQ..TYTP.YPEL.....I...R.GTA.A-PTAHNLAFEQWLKLLQDNVPLSSNNIKLIDSLYR...QSAISLMRWDSVPEPARVI.IA.R.I.LTRQYADWFGMAGWSEAINIGECWDRL..ND.S.P..E..STQP.CDMLMIMPTRLATEINGN-SG....LL...KGVATPAQFYTQQYGFE--wp...............
A0A376C478_CITKO/30-207             ......t-PLYR..RATNEGIQLFLAGSAGLLQ..ITENI..RSEQ.CPGV.....T...A.AGR.GAVSTENIAFTRWLTHLQNGVLLDEQNCLMLHELWL...QSGTGQRRWEGLPDDVRET.IT.V.H.FTAKRGDWC---DIWGSEDVSVWWNRL..CD.N.V..VpeKTMP.FDLLTVLPTRLDVEVNGFNGG....VL...NGVPSAYHWYTERYGVKW-p................
A0A085AA42_9ENTR/30-207             ......t-PRYR..HAIQQAIKLFLAGCAGILK..PTKAT..EFTA.YPML.....T...A.AGT.GASTSANQAFQHFMELMEKDAWLDSATIARMEKIWV...QSGLETLKWERI-PVSSRQ.IMsQ.L.MAVHYADWFGVASFGEQFDPQERWEWL..SI.M.P..A..ASCP.CDMLMIMPSRLATELNGN-SG....LF...RGLNTTADLYTQLYGVE--fp...............
W1J5X0_9GAMM/2-116                  plntdni-----..-------------------..-----..----.----.....-...-.---.----------------------------KRINNLYR...QSGLSLMTWDKVPEAARDV.IA.R.L.LTRQYTDWFGMVGWSDTLDIGACWDRL..EV.Y.P..Q..AAQP.CDMLMIMSTNLATEINGN-ST....LL...KEVPTTAQFYEELYGLEW-p................
A0A6I4VDD5_9GAMM/30-207             ......v-PRHR..HAVQQSIQLFLAGAAGILK..PVRTT..SYPP.FQGL.....V...R.GGT.GLSTAANQAFESWLALLLKDAVLDGETIRAIDRLYH...QSGLGALKWEIILVSARDV.VA.E.L.IIRQYTDWFGLVSAGDESDAATAWERL..SQ.Y.P..E..RSQP.CDMLAIIPTRLAAELNGA-GG....LM...SGVSTTTNLYCRQYGMEWP.................
D3V9J1_XENNA/30-206                 .......VPRYR..QAVLQSLRLFLAGCAGILK..PTKPQ..TYTP.YPAL.....V...R.GTA.AP-TEQHLAFEQWLLLLQNNVPLNTDNIKRIDNLYR...QSGLSLMSWDKVPEAARNV.IA.H.L.LIRQYTDWFGMVGWSDALDIGACWDRL..EV.Y.P..Q..AAQP.CDMLMIMATHLATEINGN-ST....LL...KEISTTAQFYEEQYGLE--wp...............
#=GC seq_cons                       ........PhYR..pAlhQSl+LFLAGCAGILK..Ps+sh..sYsP.aPuL.....l...p.uss.u.sospNhAFppWLtLLppslsLsspshppI-pLYp...QSGLuth+W-sls.su+ch.Is.t.L.hspphsDWFGhsshssp.DsutsW-+L..ss.h.s..p..pstP.CDMLhlhPT+LAsElNG..us....LL...cGlsoTtphYtc.YGhc...................
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