#=GF ID   DUF1512
#=GF AC   PF07431.16
#=GF DE   Protein of unknown function (DUF1512)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_21354 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   28.00 264.00;
#=GF NC   22.80 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR009995;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several archaeal proteins of around 370
#=GF CC   residues in length. The function of this family is unknown.
#=GF SQ   71
#=GS A3DMY3_STAMF/9-364       AC A3DMY3.1
#=GS A0A7L9FJ44_9CREN/5-362   AC A0A7L9FJ44.1
#=GS A0A0A7V2X8_9ARCH/21-373  AC A0A0A7V2X8.1
#=GS A0A6A8FIV3_9ARCH/24-378  AC A0A6A8FIV3.1
#=GS A0A0F7FIZ9_9CREN/5-362   AC A0A0F7FIZ9.1
#=GS A0A2H5V199_9ARCH/14-378  AC A0A2H5V199.1
#=GS G0QBS0_NANSJ/1-314       AC G0QBS0.1
#=GS A0A1D2WCC5_9EURY/10-359  AC A0A1D2WCC5.1
#=GS B1L620_KORCO/18-372      AC B1L620.1
#=GS A0A4P2VER5_9ARCH/11-366  AC A0A4P2VER5.1
#=GS G0EEB5_PYRF1/15-373      AC G0EEB5.1
#=GS A0A031LNP4_9CREN/23-378  AC A0A031LNP4.1
#=GS D9Q0L0_ACIS3/12-369      AC D9Q0L0.1
#=GS G0QFW6_NANS0/16-362      AC G0QFW6.1
#=GS L0AAY4_CALLD/13-370      AC L0AAY4.1
#=GS K0ICF4_NITGG/1-359       AC K0ICF4.1
#=GS A0A2H5UVS5_9ARCH/26-385  AC A0A2H5UVS5.1
#=GS A0A2T9X0X1_9CREN/15-370  AC A0A2T9X0X1.1
#=GS S5Z7I5_9CREN/6-363       AC S5Z7I5.1
#=GS A8ABJ1_IGNH4/10-364      AC A8ABJ1.1
#=GS A0A2U0S1Q6_9ARCH/1-358   AC A0A2U0S1Q6.1
#=GS E0SR34_IGNAA/20-375      AC E0SR34.1
#=GS A0A2K5ARH6_9ARCH/45-397  AC A0A2K5ARH6.1
#=GS A0A348B6W4_9CREN/22-377  AC A0A348B6W4.1
#=GS A0A4P2VFJ1_9ARCH/8-365   AC A0A4P2VFJ1.1
#=GS A0A087RN67_9ARCH/20-372  AC A0A087RN67.1
#=GS E3GXK1_METFV/7-348       AC E3GXK1.1
#=GS B8D635_DESA1/8-363       AC B8D635.1
#=GS A0A2R4ZTP6_9CREN/2-357   AC A0A2R4ZTP6.1
#=GS E6N4I9_CALS0/21-380      AC E6N4I9.1
#=GS A0A2T9WLP1_9CREN/13-370  AC A0A2T9WLP1.1
#=GS Q9YCY9_AERPE/14-371      AC Q9YCY9.2
#=GS A1RY24_THEPD/5-363       AC A1RY24.1
#=GS A0A8K0Y5B0_9ARCH/20-372  AC A0A8K0Y5B0.1
#=GS A4YIL4_METS5/25-380      AC A4YIL4.1
#=GS H2C8U2_9CREN/25-380      AC H2C8U2.1
#=GS O27876_METTH/5-346       AC O27876.1
#=GS D5U2Z8_THEAM/8-363       AC D5U2Z8.1
#=GS A0A0V8RV73_PYROC/13-373  AC A0A0V8RV73.1
#=GS A0A1D3L3B5_9EURY/8-359   AC A0A1D3L3B5.1
#=GS S2E036_9ARCH/20-372      AC S2E036.1
#=GS A8MAJ7_CALMQ/27-389      AC A8MAJ7.1
#=GS I3TD41_THEC1/8-363       AC I3TD41.1
#=GS Q4J8P3_SULAC/22-377      AC Q4J8P3.1
#=GS A0A5Q0UFP0_9ARCH/12-358  AC A0A5Q0UFP0.1
#=GS Q7LXZ0_SACS2/20-375      AC Q7LXZ0.1
#=GS A0A832V3H3_9ARCH/1-341   AC A0A832V3H3.1
#=GS A0A832V4V8_9ARCH/1-223   AC A0A832V4V8.1
#=GS V6AS49_9ARCH/19-371      AC V6AS49.1
#=GS A0A0P8Y3U5_9ARCH/20-372  AC A0A0P8Y3U5.1
#=GS F4B6R7_ACIHW/24-379      AC F4B6R7.1
#=GS A0A650CPI3_9CREN/25-380  AC A0A650CPI3.1
#=GS Q8TXZ0_METKA/10-360      AC Q8TXZ0.1
#=GS A0A550D237_9CREN/1-231   AC A0A550D237.1
#=GS A0A2H1EJ03_9ARCH/25-377  AC A0A2H1EJ03.1
#=GS A0A832XFM7_9ARCH/12-362  AC A0A832XFM7.1
#=GS A0A5B9DGH1_9ARCH/14-388  AC A0A5B9DGH1.1
#=GS G4RQ34_THETK/15-371      AC G4RQ34.1
#=GS A0A060HP75_9ARCH/36-392  AC A0A060HP75.1
#=GS A0A510DXD3_9CREN/30-387  AC A0A510DXD3.1
#=GS E1QSZ1_VULDI/25-393      AC E1QSZ1.1
#=GS Q8ZX58_PYRAE/14-368      AC Q8ZX58.1
#=GS I0A172_FERFK/11-368      AC I0A172.1
#=GS A0A0U2VCQ6_9CREN/12-366  AC A0A0U2VCQ6.1
#=GS A0A6N0NPU1_9EURY/16-367  AC A0A6N0NPU1.1
#=GS W7KXZ3_9CREN/28-383      AC W7KXZ3.1
#=GS A9A366_NITMS/20-372      AC A9A366.1
#=GS A0A2U9IF47_9CREN/29-384  AC A0A2U9IF47.1
#=GS A0RWY9_CENSY/11-355      AC A0RWY9.1
#=GS A0A830GZK2_9CREN/25-390  AC A0A830GZK2.1
#=GS F9VP55_SULTO/21-376      AC F9VP55.1
A3DMY3_STAMF/9-364                  ........l-ITQLIWLLFFIMI...FTGANQKIQMKLWSIDIRNKLSIIKRYIDEDHARIENILKNLG........VQTPSVLIK.RA....NNFFTIDPVTIEPTDIIKRMEHLIRTSDKSFRKLVSL.YLP...NLDKHERSLVETSISILSTLNLIYKVIKHYLISSEKENNWVLLMQLELIMPQIMKLVETYHEALDPFTTGKPIGDGAGPLIAHRIIED..GRV.VS.........KKVVEDTSITEVWLDDRRIFVIKAEGPGSNVGRPGYILAKLVDEL....RGSVDLIITIDAALKLESEERGEIAEGVGAAIGDPG...PEKIAIERAATKY..GIPLRALVVKMDLGDAIYTMKKDIYEACERAYEYVRKLVKELTTPKSTIIIAGIGNTMGVP.
A0A7L9FJ44_9CREN/5-362              ......tyn---LILWLIILTFF...-SFFTQEMQILRAISEVENYLLVFRSARDKSLSFLASQLKRYSgi....hdDRLLENKVN.EL....VETYVILPVDIDPYGIVKKIKHILRTSERGLEERIAQ.IAP...KATRVDVQNLSNIVELARALNIIYKVLNHYYLIARKFRSLWLLMQLSAQMPFVMEEVKAIEGALEAFRHNVPIGDSAGPLVASYLARKyaAGQ.TF.........LEPVDNTIVYSLNLEERKVYVIKAKGPGGSVGRVDEALQWVLERE....--RPTHIVTIDAALRYEGEESGTLAYGYGVAMGGIG...AERFTIEELATKN..NIPLYAVLIKVSEAEALSVMTEDIYRGVKRAVDVVENFVKSQ-PPGSVIVVIGVGNTVGVP.
A0A0A7V2X8_9ARCH/21-373             ........t-LMMLIWILPVIIF..vFYG--QRIQLMISSNEIKKDIGKLDEYTTSTKKDFLNYVKNNLt......sKSDPSKKLD.SF....FDYFTIMPVDMDPNGIITKINHLIRSREDFIRLQING.MFS...NLSSVELSKLQNLLEIVTTLQLFHKHTRHLYLTAKKQKNFPLILPLQMMIPFIMEEALALKDAMPAIKNGQPIGDGIGPMIVGQMMLG..TTK.E-.........-SAAFETVWSKTTFEDRELFLMKAEGPNATVGRPGDGLEKIISIK....--KPDLVIMIDASLKLEGEDSASIAKGFGAAIGGIG...TERFKIEEIATRN..NIPILALVVKQSIHEAITLMTEDIANSAKTVKDELHQMIRENTTSGQSILVIGVGNTIGVS.
A0A6A8FIV3_9ARCH/24-378             .......pl--AYILWFAPIIVL..mIYG--QKFQAWMILGDVSKSLTRLKTMKETARKEVIDYIKTSIr......pAADPSERID.KF....LEYFVIMPVDLDPQGIIRKLDLVMRTKDERIRSEIKR.MAE...GMTEWQASRIENILEAATALNMIYKIVRHFYLMGKRTTGMFVLVQLQMVMPLLLQEAEALESAISAFKKGLPIGDGIGPMVVGRMMLG..KEK.K-.........-PIARETVYSEEVRMGRKLYMLKAEGPAGSVGRPGEAVYRLIAEL....GLRIDAIIMIDAALKLEGEKTGAIAEGVGSAIGGIG...VERYQIEDVATKF..SIPIYAIIVKQSVQDAITVMRKEISDSFDKLNNTVSAVIEDKTLEGDSILVIGVGNTAGVG.
A0A0F7FIZ9_9CREN/5-362              .......ty--SLIMWIIVLMFF...-SFLTQEMQIFRAISEVENYLIIFRETRDKSLKLLAAQLKRYSgi....kdDKTIETKVT.EL....VETYTILPVDLDPFGIVKKIKHIVQVGEKGLEERLHL.VAP...TASRDEILNLSNLVEVARALNIIYKQVNHYYLIARRFKSLWLLMQLSAQMPFVLEGVRAIEGALESFKYGVPIGDSAGPLVASYLVRKnaPEK.RP.........LEPVKDTEVYDLELDNKKVYVVKAKGPGGTVGHLDEALQWILERT....--TPTLIITIDAALKYEGEESGSLAYGYGVAMGGIG...AERFIIEELATKN..NIPLYALLIKMSEAEALSVMTENIYKGVKNGLQVLEEFIRGLPA-GSVVVVIGVGNTVGVP.
A0A2H5V199_9ARCH/14-378             ......vlf---QLLWFLFLLTFffiYPYFGQKTQLAFILRYIEKRLAVLKQIRDEVKERTVSTLKLYVdd...nkdSAAMEKELE.NL....LEFFYIPPESMDPSGIVYKLEHILEIGDSRFEESVSR.MAP...KADIHRVKSLSNLVEVARALNIIYRVVRHYYLLGKRMANYFLAVQIQIQLPMIMELAESYRQASYAFLKGLPIGDGIGVLSAAKFVRE..SKKiSD.........MEIAKDTWLEVVEFEGRKVYVVRPIGPGGTVGRPGEAVKKLVYEM....DTKPDLIITIDAALKLEGEETGKIAEGVGVAIGGPG...IDKFKIETIAKEK..NVPLYAIVIYQSILEAITPMRESIVKSADIVVNRVKELIRDKVPSNGTAVVAGIGNTIGVG.
G0QBS0_NANSJ/1-314                  .......mv--------------...----------------------NLDEYRSTAEDEFLEKLQPDR........TQRFEEKYG.AL....KDFKLSPPTGIDPAGLVGKFENVLDASDSKFERFVKR.NAS...TEDEDEIADMQMAFRGVLGTHQVFKMLRHYRQLINKTQNFQLVSIVQFMVPIYTEIAEAQKDATRAFADGAPIGDAIGPLVAAQLIED..DP-.--.........EEVAENIVHSEEEIMDTEVHVIKSNGPGARLGKYGDAIDKVADEN....--DLEAVITVDAAAKLEGEDTGAISEGAGVMMGGPG...VEKSKIEDAAERH..DVPLEGIIVKQSPSEASKPMKKEIYNSWESAVDRVQRNLDEFDGP---VAVIGVGNTCGVG.
A0A1D2WCC5_9EURY/10-359             .....dimg-------ILVIVLL...-IFLIPWIVRVRALSSVNKAALELENMVRELEDFLIEISKEKGk......pILDPSAKIE.GF....MEFFVVPPVDLDPNGLVRKFEKILDLSEDRFKQMINE.VAP...LADVETKANIVMTLKATLAINDVAKQVRHNLELGRKG-NLQILLMLQMSIPLIMRVVKAQFEGAKTFSEGKPIGDGAGPIVAGLLMKD..YKN.EY.........ITEIEDMFIAKKKMEERDLIIARAKGPGARVGRVGKVVRSILAKE....--NIDKVITVDAAVKLEGEETGKVARGIGVVIGGPG...VDKWAIEEEIVKR..NIELDAVIVKMSPEEAISNMNQKIADASLEAFELVQELIYNSPDDT-NILVVGVGNSCGI-k
B1L620_KORCO/18-372                 ........w-LSWIFFIIFIMIM..qFY--ANRLQAQIWISEISRALSKLEEYSNDSARKFIEEASKYGr......sQEEVKSIYN.KV....KGFFLIEPVTLDPYGAVRRLEHLLNTMRDHLNALMKD.IAP...NADGWKRSNLRDQMASALTLDMIYRIIRHYFILGRKTQNLIYIAQIQMLLPEIMRIAKAYWKAGDAFRLGIPIGDGIGPLVALKLMNG..AEF.T-.........-EIAENIVGAEVDIEGRRVMVIKAKGPGSEVGRPGLAIERIVEGR....EGKVSLIITIDAASKLEGEPTAEIAEGIGAAIGDPG...PEKYKIEEVATKY..AIPLHAIAIKEDQLDAITSMSEEIARSVDEVIGRVKATIVSKTLPGDYVIVAGIGNTMGIG.
A0A4P2VER5_9ARCH/11-366             imamtlagl--------AIVAAF..iFYG--MRIQLDSMLWQLNKHIKRAQGLSASARKRLISELLRYYg.....snEHELSAKVD.AA....LNSLVIQPISLDPHGIVPKLDHVLRIWDKSLEDTVER.LAP...GAGPISRKNMTNLLELTVELERLRKILEHYYASAKKDHDLISLSYLQVYLPFFMEEAEALSSGVDALTKGAPIGDALGPMVVRSLVGD..ARP.R-.........-RIAEDTIFYELEMDGRRIIAVKAEGPGGTVGRPGEAVERLLEIY....-RGTKLVISVDAALKLEGEETGSLAEGVGVAMGGPG...TDRFYIESAASKM..GVPTYAVVVKMSEKEAISEMPGAVRAAVPAAVEAVRRAVRENTLPGDTVIVVGVGNTIGVP.
G0EEB5_PYRF1/15-373                 .........MISQLIFTIVFLMM...FLGVNQRIQVALWARDVRGKLAILRSYVDDAISRAVEYLRSAG........VRDPHSLVS.RV....SRYFIVHPVDIEPVDIIRRLERVLRTKDETIRSWVLD.ALPpekRGDETLVNNVETLVGIAGALDTLYRLVRHLFILSLRYNNWALMMQLVLVMPMLLRVARSYRDAAQVVSEGRPIGDGAGPLAAFLLAKK.lGVS.PE.........GEAAHNTVYYRAVLDEREVYIIKAKGPGSTVGRPGEAVENIAKRV....GDKLAAIITIDAVLKLEGEETGEVAIGAGVAMGDPG...PEKIKIERIASRL..RIPLHAIGIKMSIEEAITGMRKEIADAASRAAKIVEDIVKSVER-GKAVIVVGVGNTVGIG.
A0A031LNP4_9CREN/23-378             ........t-ILYIVFMGFIVAS..fFPGFQQKMQIGFLSRDVEKNLYMIEGYLKDSKSMAEKLLKDKN........FPEPQQFIN.KV....MERFVIDPVNIEPTDIISRMKLLLRANEDTVREMITK.YSP...NIDPMTRSQIEISAEVVNALNMIFKIIRHYLLMAKKLNSIMIMYQLQMVAPIYVKLAEAYARAQKVFLQGIPVGDGLGPLVASRFLMN..IND.K-.........WVPSKDIIAGTMEFEGRRLIVVKAEGPMATVGTPGEAVQNIIEKE....GSKVSRIITVDAALKLEGEDTGSIAEGMGVAMGDPG...PEKIAIERVATKY..NIPIDAVIVKMSMEEAITEMRKEVYDSADKVVNYVKDLIRERTKPGDSVVLVGVGNTAGIA.
D9Q0L0_ACIS3/12-369                 ......vgv---NILWIALLFLW...LTGLGNWIQVYWYRADIRSKLNLLGGLADEAKKATLDFMNKNN........AKDAASLLD.RL....TDFFTIDPVSVEPTDIISRMRHLLNIRDMRFKDSFIE.AMP...NSDDVTRSIASTAAEITSALNFIYKYVRHLLLFSEKTKNWYLILQLEIFMPQIVQLAQTYRKALDDFLTKVPVGDGAGPMVALRLAGP..DAK.W-.........REVTEDTVVTETNFEGRNIILVKAKGPASTVGRPGEAAEKVIREAi.aqGRKVSLMITVDAALKFEGEATGDVAEGVGAAIGDPG...PEKIRFERVATEY..NIPLRAVIVKMGMDEAILAMNQDIYNGVEKAVERVKQIIRSESREGDTVVVIGVGNTAGVG.
G0QFW6_NANS0/16-362                 ....livqt-ITTLLFFVGIFFF...-----PKIMLWQIDRKMRSALENLDTFRTDTEEMFRSKFVDNF........SEDLEDKMD.SL....KNTKFSQPTGLDPAGMVGKLEHVLDTSEDKFKRFVDK.NAD...TEDEDELADLNMAFKGVMGTHQIYKVVRHFRKLIKGTQNIQLVGLVRMMLPVYEELAESQKGATRAFLDQAPIGDAIGPLVAAKMITD..EP-.--.........EEVSKNIMHSEEEINDETVHVLKSDGPGARLGKYGEAVDQLAEEN....--DLEAIVTVDAALKLEGEETGTVSEGVGVMMGGPG...VEKTKIEEAATEH..DIPLEGIVIKQNAPEASKAMKKEIFDSYQEAVDKAQEIASEYDG---EVAIIGVGNTCGIG.
L0AAY4_CALLD/13-370                 ........l-LINVVWVLIFVLY...LFGFGNYLQVYWWKADIKNKLAILNDMANTARNKTIEFMNKNK........AKDASRTLD.RL....IDFFAIDPVNIEPTDIINRLRHIVNLRDTKFKQTFEI.SMP...ESNEVARSIASTAAEISSALFLIYKYVQHILLSSDKTKNWYMIMYLSLMMPQIMQIASIYRKALDDFLEGVPVGDGAGPIVALKLSNY..KND.W-.........REIDEDTVATETEYNGRKIILVKAKGPGSTVGRPGEATAKIIKEAl.akGEKVSLLITVDAALKFEGEETGSVAEGVGAAIGDPG...PEKIMFERIATEY..NIPLRAVIIKMGMEEAIMAMDKKILDGTDKAVERVKQIMEEESKPGETVVIAGIGNTSGVG.
K0ICF4_NITGG/1-359                  ......mwv---YIISIAIIPFF...M-MYAQKFQSRVILGEISKSLVKLKTMKEGARKEAVDYIKTTVktt..tspSSDPAAGVD.RF....LEYFAIMPVDLDPNGIVRKLDHIMRVRDDRLRAEVRK.LCA...GASDQEVSKIENILEAATALNMIYKIVRHFYLMGKRTTSMFVLVQLQMVMPLLLEEAEALQKAINAFKRGQPIGDGIGPMVVGKMMLG..KEK.K-.........-LAARETVYSEDEYKGRKLYLLKAEGPAGTVGRPGEAITRLAGDM....GIKIDAIIMIDAALKLEGERTGEVAEGIGAAIGGIG...VEKYQIEEVATRL..DIPVYAVIVKQSVQDAITIMRKEIADAFDKVTNTVYSVIEDKTSEGQSVMVIGVGNTMGVG.
A0A2H5UVS5_9ARCH/26-385             ........i-IISFVWLLMFMVFf.lYPSFGQRMQLSYMLRDLERKLNKLKSIKDEIRQTAIDTIKKVGk......pDFDPTPEVD.RL....SEFFVIPPESMDPYGIVYKLEHILEIGELSYENEVKK.LAP...IAEEHQVKTLTNLVEIARGINTLYRVVRHYYLLGKKTSNIYLVLQIQMIMPQLVEIAEAYRMASVAFSQGQPIGDSIGVLVAAKLSDV..ENK.KR.........YTVARDTMVEELELENRKVYVVRAIGPGGTVGRPGEAVKNLVESL....PENPKMIITIDAGLKLEGEESGKVVEGVGVAIGGPG...VDKYKIEEVAKQR..NIPLYAFVIFESIQEAITPMRESIAKAADVVLQKVRKLLTEKVEEGGVVVVAGIGNTVGVG.
A0A2T9X0X1_9CREN/15-370             ........l-ISTLLFIAFLLIL..sIPDIQLGFQMWRLSSIVEKELGEIKRMSDNARNKLIDMLKSLN........AKDPQGLVD.TL....AEMFVIDPVSVEPIDIINRMRHLLRGGESKIKLLIKD.SVP...NADPVTISKLEVSAEVVNALNLVYKVVRHYINLAKKLKSPMLMYQVQMVIPILKRMAEAYSKAQDTFRDGKPVGDSLGPLVAARLMLN..ATR.K-.........WEPAEETVAAETIVEGRKVIVVKALGPLATVGRPGEAVARIVEEH....NGQIARIITVDAALKLEGEQTGSVAEGVGVAMGDPG...PEKIAIERVATKY..GIPIDAVIVKMGMEEAITDMPKEVYDAAEKAESLVRKIITERTPIGSSVIVVGVGNTSGVG.
S5Z7I5_9CREN/6-363                  .......fd---LVLWLIILTLF...-SYLSQEMQILRAISEIETYIAFFKSTRDKAVNVLVSQFKRYSg.....dgSKEFEAQLErRLs.slIETYIIFPVDLDPFGIVKKIKHVLRTGEERIEKEVAA.LAR...NASPADVQNLANLVEVARELNIIYKLVNHYYLIARKFKSLWLILQLNAQMPFVLEEVKAVEGALESFSKGLPIGDSAGPFVASLLVRR..YKG.TY.........IEPVKDTYVSKINVENRNVYVVRAKGPGGTTGRLEEAVAWVLSRE....--KASLMISIDAALKYEGEESGLVAHGFGIAMGGVG...VERFEIEELAAKH..GIPTYAVLIKMSEAEALSTMTEKVYRGTLQAVDIVTDLIRQYPEN-STIIVLGVGNTLGVP.
A8ABJ1_IGNH4/10-364                 .........VITQLMFMAFLLMA...FTGADARLRMYIWAKNIRVKMEEIKGYAEESEKETLEVLKKLN........VKNADEIVR.RI....KEFFHISPVDIEPTDITKRMAHIIRTGQERWERLLSS.SLP..eDVPRAHKHNAMVMLEITNSLNTIYKIVRHYLLTSLKTNNFFLMMQLWMLMPMISKMSKTLRDALDTFKNCRPVGDGAGPLVAFRLLIN..KKR.L-.........WRPAKDTVAGEVDIEGRRVIVIKAEGPGATVGSPGEAVQRVVEEL....RGKVDLILTVDAALKLEGEETGQIAEGSGAAIGDPG...PEKIAIERAATKY..GIPLEAIVIKMSAEEAITDMPEKVAKAVDLVVQKVIERVKELPK-GATAIVAGIGNTCGVA.
A0A2U0S1Q6_9ARCH/1-358              .....mlsy-IFNIVYIVFVFGF...-SFFSQKIQVNLVLGKISKSLKKLQLMRDKAKDEAVSAIIALGk......pESDPKPRVE.AL....LQFFAIQPNSMDPSGVVNRLEYLVNTADDRVKEEVKT.LAP...SADEKQIQNLQNLVETARGLNSLYRTVRHHYLVGKKGGTIYSTMQIQMQLPMIMEEAEAYFSFIDAFKKGKPIGDGVGPLVASTLIGD..ASV.--.........RDVAEDTITAEVTVEGRKVVVTKAKGPGGTVGKVGTAVGKLIKEH....KGNVSLIVMVDAGLKLEGENSGFVVEGVGAAIGGVG...VEQFKIEEVATKH..KIPVYAMIVRQSLKEVLAPMTDTVTNSVDEVIKRLGRIIRERTKEGNTVLVVGVGNTIGIA.
E0SR34_IGNAA/20-375                 .......ti-LSILLYMVFFLYF...FTDLPQKTQFMRYERGVASRLAVVESLVRESINKVRSYLSKLG........IKNIDKMIDtSL....ENYFVIEPVSIEPIDIIKRLDHMITNNENKFKKDIES.LSP...GLNRHVLNNIAVSLAIASALYTIYKILRHYYLLGKKYENWVLLMQLYLLMPQLVKELIPYVKAIDGVSRGIPIGDSAGPLVAYKISLL..SPR.I-.........-DIDEDTVYSVVDIDGRKVYVVKAKGPGSTVGKPGKAVAKIAEML....NYKVSRIITVDAALKLEGEQTGTVAEGSGAAIGDPG...PEKIEIERIAVKC..NAPLDAVIIKMGADEAIKPMSKEIADGVEKAYQKVLEIIRTRTNPGDTIIVAGIGNSVGV-y
A0A2K5ARH6_9ARCH/45-397             .......wv---YLLWIVPFFIF..lLYG--QRIQMWMVLNDVARSLNRLKSMQDKARDEAIAYLKSVN.......pNLASTERFD.MM....MEHFAITPVDMDPYGIVRKVQHIIRLRDDRIRAQIRM.LAP...QADEVTASRLENVLEVATALHMLYKIVRHFYLMGKKTTSMFFLVQLQMLMPLIMQSAEAFNKAIPAIKNGQPIGDGIGPMVVGRLMLN..RAK.I-.........-PIARDTVMSEYEYNGRRLYLVKAQGPGGTVGEPHTAVERLINEM....GVKVDMIIMIDAALKLEGEKTGDVAEGVGAAIGGIG...VEKYQIEEVATRH..SIPLYAVIIKQSIIEAITAMRKEIAEAVERASKSVFRMIDEHSNEGDNILIIGVGNTLGVG.
A0A348B6W4_9CREN/22-377             ....yipff----VLMLFYVILF...LPGVGQRFQSYFITREIEQRLMVLEKYANDARNTTEKLLKEKG........AKDPKGLTE.RL....AEIFVIDPVSIEPTDIIGRMRLLLRTGQGKVKSMIKL.SVP...NADPVTVSKIEVSAEITNALNMVYKVVRHYLIQAKKLNNFYLLFQLQMVVPMLVKIAESYDRAHKTFVEGKPVGDSLGPMVASRFLLN..SEK.K-.........WQVSDETIAGETYYEGRRLIVIKAEGPMATVGTPGEAVERVVEEN....KGRVKRIITVDAALKLEGEKTGSIAEGTGVAMGDPG...PEKIAIERVALKY..QIPIDALIVKMGMDEAIIEMKKEIYEAVDPVVEMTKQIIKERTEEGDTVVVVGVGNTSGVA.
A0A4P2VFJ1_9ARCH/8-365              iyyylawyi-----VLPAIYVAL...MTIYANKFQFWTMSGEVNRAFRELKGLRDSGISKFNAYISAAT.......qDESSRSRLR.SL....LDLFAVSPVDLDPVGIVPKLKHLMDEYEQRFKSEAST.ALK...SNDPVLIGKTVGYAEAAASLDILYKIVNHFLWLTNKYSSLGLLQQLYAIMPLVLKMGKSFLGFMDALEKGAPIGDGIGPMSVGLLMLG..AQK.F-.........-DIAPDTSAALTKMEDRRVLLVKAKGPASNLGHLDDAVQRARLIY....-GGISAIITIDAQLRLESERSGDTARGVGVAIGGLG...VERFNIEEKASEE..GIPLYAILVKESYIEAITAMAKDIAESVDAVHDALREVLREKVPPEGLAVVIGVGNTLGVA.
A0A087RN67_9ARCH/20-372             ........p-IMMLVWIIPIILF..vFYG--QRIQLIITSGDIKKKLAELEQFRNDSRNELIQYVKKNLa......aKDNVTQKFD.RF....FDYFTVMPVDIDPNGIIPKIHRLIRSREDTTRKQIQS.LFS...EIDTMEITKIQNLLEVVTYLQLLHRIVRHLFLTAKKQNNYPMILPLQMMLPFIMEQAEALKDAVPAFKQGQPIGDGIGPLVVGEMMLG..TKK.Q-.........-KAEFETVYSESKFKDRKLILLKAEGPYATVGRPSEAAQVLVEQY....--KPDIIVMIDAALKLEGEDSGTVSQGFGAAIGGIG...TDRFKIEELATKF..DIPIFSIVVKQSVKDAVTLMKKEIANQAENVKNQVHEMITDNTNSGQTVLVIGVGNTLGVS.
E3GXK1_METFV/7-348                  .....ttgl----ILLLIFLIIF...-----PMVMNQMLLRNVSRYVEEMEKKVEEAEKLIIKMCKRKH........----SKELK.KF....LEFFVAKPSRLDPHGIVKRFEKILNMSEKRFKEVADK.VLE...DLDEEKKSNFIMALKSTLSLKSTAKIIRHNLELAKKTKNFQILIALQMNLNLIRRFFEAQFEGVKAFSKGLPVGDSAGVVVAGALMDG..NDD.L-.........-KEMGDMVYTKKSIDGRNVIIVRSKGPGARIGRVGRVVTRLIDKN....--NIDHLIMIDAAVKLEGEKTGSVAEGVGVVVGGTG...VEKWLIENKITEK..DIDVSSVIIKMSLEEAVSQMNKKILEGCKKAIKIVNKMIERYEKDS-NILVVGVGNSSGIP.
B8D635_DESA1/8-363                  ........l-IIQVIWLIMFFLI...ITGLNQKIQMKIWVTDIRMKLDLIKGILEEDKQKTKVMLRNLG........IQSPEPLID.RV....IEFFTIEPVGIEPVDIIKRMDHLIRITDTTVRRLIEA.EIP...HAGKYERSLVETTLSIVGALHVIYKVVRHYLLTGEKENNWILIMQLQLQMPQILKYVNTYHEAFDAFATGKPIGDGIGPLVAYRLIES..GRK.IS.........SRILDDTSITEVWYKDRRIYVVKAEGPGSNVGHPGAVINRLVDEL....KGSVDLMITVDAALKLEGEKSGSIAEGVGAAIGDPG...PEKIAIERAASKY..GIPLRALVIKMDLREAITVMRKEIFEAADSTLKYLERIIEEHTKPNSTIIVAGIGNTMGIP.
A0A2R4ZTP6_9CREN/2-357              .....llfw---IIINILWFLLL...FTDLPDKIRIYRWDRVIRFRLSQIEGLALETRKASEDHLKELG........IKEPGPVID.GF...vNNNFLIEPVSIEPIDIVRRLGHLIRVRDDKIKSYAAS.ILP...NADQAKRENLEVILEINWVLSYVHRVVRHFYLLGKKTQNWMLLYQLVLILPALIKELEAYKKAVEPFRLGIPIGDSAGPLVVSMMAPN..AER.I-.........-RITDETVYSTIDLEGRRVYLIKAEGPGGTVGRPGEAVAKLAEQL....ECRISRIITVDAALKLEGEKSGEVAEGTGAAIGDPG...PEKISIERTAIKC..GAPLDAVIIKMSSEEAITHMTKEIYEGVSKAVEVVKRIIRERTKEGDQVIVAGIGNTLGV-l
E6N4I9_CALS0/21-380                 ........l-LLSLVWFAFLMIFf.lYPSFGQRMQLSYMLRDLEKKLNKLKLIKDEINQITVETIKRVGk......pEKDPAPDIN.RL....SEFFIIQPESMDPYGLVYKLEHILETGESVYEQEVAK.LAP...HATEHQVKSLTNLVEVLRGINTIYRVVRHYYLLGKKTANIYMVLQIQMVLPQIIEIAESYRQAAVAFSKGQPIGDGVGPLVAAKLVNG..MEK.ER.........YEIAKDTVVQEIELENRKVYVVRAIGPGGTVGRPGEGVKQLVERL....PENPKLIITIDAALKLEGEETGKIAEGVGVAIGGPG...VDKYKIEELAKSR..GIPLYAFVIFQSITEAITPMRESIAKAADQVLEKVKQLILEKVKSGESVVVAGIGNTIGVG.
A0A2T9WLP1_9CREN/13-370             ........l-IVNILWVALLLLW...LTGLGNWIQVYWYRADIRSKLAILGGLADEARKETLDYMNRNK........AKDASSLLN.RL....LDFFVIEPVEIEPTDIINRLRHLINIRDARFKDVFNQ.AMS...DSDEVTRSVASTAAEIASALNFIYKYVRHILLFAEKTKNWYLILQLAIFMPQIIQIAQMYRKALDDFLYKVPVGDGAGPLVALRLAGF..GAK.W-.........REVTEDTVVAESELEGRRLLIIKAKGPGSTVGRPGEAAEKVIREAi.aqGRRVSLMVTVDAALKLEGEDTGDVAEGVGAAIGDPG...PEKIRFERVATEY..NIPLRAVIVKMGMDEAILAMNQHIYKGVENAVERVKQIIRSESREGDTVVVIGVGNTVGVG.
Q9YCY9_AERPE/14-371                 ........a-ISQLLLVLIFIAL...FTGANQRIQVYLWSRDIRSKLVILESFANDARRRAVEYMVSKG........AKDAESLVS.RL....ADFFVISPVDIEPVDIIRRLEHLVNLRSRRFKEEVAR.HMP...EADEVSRSKAEVALEIASALSFIHKYVRHILLTGEKTRNWILIMQLQLIMPMILKIADTYRRALNDFLKGVPIGDSAGPMVALRLAGR..GAR.W-.........ERIEEETVYTVADVEGRRVYIVKAEGPGSSVGRPGSATERLIEKLv.aqGRKPRLLVTVDAALKLEGEETGSVADGVGAAIGDIG...PEKIRFERIAVKY..GIALRAVAIKMGLEEAILGMTEKIVKGVEKAVERVKDIIRGESKPGDIVVVVGVGNTVGVG.
A1RY24_THEPD/5-363                  ........t-LSFIMWLVALAIF...-SYITQEMQILKAISEVEGYVALFRGIRDKAVKVLVDQFSKYTa.....ssEGASRDVLEqRIl.slIETRIILPVDLDPYGIVRKIKHVLRTSEVELEKEVSR.IAK...GASRTEVQRLSSLVEVARELNLVYKLVNHYYLIARKFKSLWLVLQLNAQMPFVLEEVKAIEGALESFSKGIPVGDSAGPLVAALLARK..YKG.SF.........VEPVKDTEISQVTVDGKKVFIVKAKGPGSTTGHLEEALSWIFSRE....--KVSLIVSVDAALKLEGEESGSVASGYGVAMGGIG...VERFEIEELSTKH..GVPLFAVLIKMSEAEALSVMTEKVYQGVQQAVRIVEDIISRAP-EGSSIVVLGVGNSLGVP.
A0A8K0Y5B0_9ARCH/20-372             ........p-LMWLVWIVPIFVF..mLYG--QKIQLQITSSEINKSLEKLKTYRDDTRKELIDYIKNTLk......pNWDISPRLD.RY....IEYFTIMPVDMDPNGIVSKIRHIMRTRENFTREQVRT.LAT...ELNSLEASKIANILEVVTTIHLLYKSVRHLFLTAKKQNNFPLILPLQMMIPFIMEEAEALRTAVPAFKQGQPIGDGIGPMIVGKMMVD..TKK.M-.........-EAAYETVWSEKEFEGRKLLLMKAEGPSGTVGRPGEATEKIISKV....--KPDIIIMVDAALKLEGETTGSVSQGFGAAIGGIG...TEKFQIEEVATKH..EIPIYAVVIKQSIKEAITLMKKEIADASEKATSQIYDMIKENTKTGQAVLIIGVGNTIGVS.
A4YIL4_METS5/25-380                 ........y-IFYIFFIALLALS..fFPGVQQKTQIMFLSRDVEQKLQMIEGYLKDSRGLTEKLLKDKG........FADPKAFVD.RI....IDRFVIDPVSVEPTDIINRMKLLMRSNEDTVREMITA.ANP...NIDPMTRSQIEISTEVVNALNLIYKVIRHYLIMAKKLNSIMIMYQLQMVAPIYVKYAEAYAKAQKVFLQGIPIGDGLGPLVASRFLMK..ADQ.K-.........FTVSKDTIAGSIEFEGRKIVVVKAEGPMATVGTPGEGVQNVIERE....GGRVSRIITVDAALKLEGEETGSVAEGMGVAMGDPG...PEKIAIERVAVKY..GIPIDAVIVKMSMEEAITEMRKEVYQAADKAIEYVKRIILERTKPGSTVVVVGVGNTAGIA.
H2C8U2_9CREN/25-380                 ........y-IFYIFFIALLALS..fFPGVQQKTQIMFLSRDVEQKLQMIENYLKDSKSITEKLLKEKG........FPDPKAFLD.RV....IDRFVIDPVSIEPTDIINRMKLLMRSNEDTVREMIMS.ANP...NLDPMTRSQIEISAEVVNALNLIFKVIRHYLIMAKKLNSIMIMYQLQMVAPIYVKYAEAYSKAQKVFLQGIPIGDGLGPLVASKFLMK..SSQ.K-.........FTVSKDTIAGTLEFEGRKLVVVKAEGPMATVGTPGEGVQNVIERE....GGKVSRIITVDAALKLEGEETGTIAEGMGVAMGDPG...PEKIAIERVAVKY..GIPIDAVIVKMSMEEAITEMRKEVYQAADKVIDYVKRIILERTKPGSTVVLVGVGNTAGIA.
O27876_METTH/5-346                  ....ildil--GMAAFILLIILL...-----PAIVRMRIFSAIEGAIAELEDMEGDAMKILAELAE---........PEDPRT-LE.DY....LEFFIIPPSDIDPAGLADRYRRLLEMGDLRLQKLVER.FPP...AADTERRASIIMCIRVAAGMRGILKFLRHNLELARKTGNLQILVALQMNLALIMRTARAYMDGCRAISRFLPIGDGAGPLTAGMLIEN..RDQ.R-.........-EHLHEMVYVKKRFMGKEVGILRPRGPGSRLGMMIKAMEEILTRD....--EFDEIIMVDAAAKLEGEKTGAVACGMGVAIGGSG...VEKWFIENLVLEH..RT--HSIIIKMSPEEAMSQMPEDVLGGCRVALEQIKGIVSESDAD--SILIVGAGNSSGIP.
D5U2Z8_THEAM/8-363                  .........MIVQLVWLVFFFLI...ITGLNQKIQTKIWIMDIRAKLNVIMSLVEEDRRRVANMLRNLG........VAAPDILIN.RI....VDFFTIEPVEIEPTDIIKRLDHLVRTTDESVKKMVEA.TIP...HVGKYEKTLIESSLSIVGALNTIYKIVRHYLLTGERENNWILIMQLQFQMPMIMKLVNTYHEALDAFSTGKPIGDAAGPLTVHRLIEN..GQV.VS.........RRVIDETSIIELYYKDRRVFVIKAEGPGSNVGHPGAVLNKLVEDL....KGNVDLIITIDAALKLEGEETGSLAEGVGAAIGDPG...PEKIAIERAASKY..NIPLRALVVKMDLREAITVMRKEIFEACYKAYKYVDKIIEEETKPKATVIVAGIGNTMGVP.
A0A0V8RV73_PYROC/13-373             .......ia-ISILISTVLSIMA...FFGAAQGLQLRIWRSQIESRLRILAGYRDKAREEARKKLEKLG........SKDPDAVLN.TV....MDYFVIEPVSIEPTDITKRLERILRTEEERIEEVISR.SLP..rEVDDAEKKNVATLLVIANALNMLYKYLRHILLLGVKTRNAMLVAQLWMLLPLYMRIAKAYYDAVGVVSKGVPIGDAAGPLAAYKLMRMleVES.EP.........REVTKDTVYSVHRYEDRRVVIVKARGPGSTVGRPGEAVEKIVSEE...lQGNVAAIITVDAALKLEGEETGSIAEGTGVAMGDPG...PEKIRIERIAVAH..GAPLYAIAIKMGLEEAITAIKKEVVDGVEKAVERVKQLILEATRPGDTVIVVGVGNTLGVA.
A0A1D3L3B5_9EURY/8-359              ......idi-IGFVIFFILILIL...-----PSFLRMRAMSSISNFTVEVEGMVEESKNVLIKLCSEKGn......pKGDPKAALD.NF....LEFFVIQPAELDPNGIVRKFEKILDLSEDRFSHMSKT.LAP...EADAEWTSNIVMTLKATLGINGVAKMVRHNLELAKKTGNIQILLMLQMSLPMIMRVVKAQYEGMHAFSEGKAVGDGIGPIVAGTLMKD..VEK.PD.........IHEVGEMVVGKTHFQGRELIIARANGPGARVGKVGKVVTSIIHEK....--NIKRLLTIDAAVKLEGEKTGTVAEGVGVVIGGPG...VDKWMIEEELVKS..DLQTDAVIIKMSPEEAISPMTKEILESSRKAVSVVEHAIMESPE-GSSVLVVGVGNSCGVP.
S2E036_9ARCH/20-372                 ........p-IMMLIWILPIFIF..vLYG--QRIQLAVTSGEIKKGIKKLDEYKTQSRTELIDYIKKNMn......pKDDPTKKID.RF....LDYFTIMPVDMDPNGIVSKVRHIVRAREDYSREHVRS.LSP...QTSDIELSKIQTLLEIATSLQMIYKVINHMYLTAKKQNNYPLILPLQMIMPFLLEEAEAMQKAIPAFKTCQPIGDGIGPMVVGKMMLD..TKK.E-.........-SIAFQTVLGMTDYSERKLLLLKAEGPASTVGRPGDAVEKIVSKD....--RPDMIIMVDASLKMEGEESATTAQGFGAAIGGIG...TERFQIEDIATKN..NIPIFAIVVKQSVKEAITLMTKEIADKAENVRSQIYEMIDDNTKPGQTILLIGVGNTMGV-q
A8MAJ7_CALMQ/27-389                 .....ilynIILLVLWFGVFPWF...----YETFQLWRYQSQVSGFLNRLRVSMNNNITQVLDFITSKV........NEDK-KLIEsRIr.dlMEMVIIEPTSMEPEGLVRKYKALINSYNDRLEKDVSR.LMPs.iSNSRPIIQNFTNVVDVLRELNFIYKVIDHYYRLAMKYKSYYLLIQLAAILPLLKEEIDALNGSVPAFLKGQPIGDSAGPLTVFRFKNLcsNLE.PI.........GDSIKDTYIASCNFKGRKIYLVKAEGPGGTVGHLDDAIRYIYESI....NARPRLMITIDAALKLEGEESGSIAEGLGVAMGGIG...VEKFNIESIATKY..DTPIYAILIKMSMPEALNAMTKPIDEAVNKVVERLGKVIDSYSDPNDEVIIVGVGNTIGVA.
I3TD41_THEC1/8-363                  .........LITQIIWLIIFILL...ITGLNTKIQMRIWAMDIRNKLNLIKRIIDEDRVRVEKMISNLG........YQTPSALVG.RV....LDFFTIEPVSIEPVDIIKRLDHMIRTSEATVRRFVES.SLP...NTGKFERSLVETSIEVLAGLNLIYKVIRHYLLTGEKENNWVLLMQLELLMPTIMRYVETYHMALDPFMSGKPVGDSVGPLVVYNLLEK..SKV.VS.........KRVIEDTSVFETWLEDRRVFFVKAEGPGSNVGHPGAVIRKLVEEL....KGNVDLIVTIDAALKLEGEETGSIAEGVGAAIGDPG...PEKIAIERAAAEY..GIPLRALIVKMDYREALTVMKKEIFEASRKAVDYVLKLIKEETKPNATVIVAGIGNTIGVP.
Q4J8P3_SULAC/22-377                 ........f-ITYILFFAVIILT..aLPGVQIRLQMYWASMDIERGLTRVKRVLDSTVSKTKQILEKNG........ASNSDEITR.KF....SDMFTIDPVNVEPTDIISRMRLLLRSTEDKIKQVINV.SIP...TIDPMNRSKIQVSAEIVNTVNIIYKVIRHYLLLGRKLQNYYLLLQLQMIVPMLVRMAETYEKALDVFLQGVPVGDSLGPLVASRFLMN..VSE.K-.........WSPSREMIAGTTVYEGRRLVILKAEGPMATVGTPGEAVENVIGKL....NGSVSRIITVDAAAKLEGEETGEIAEGTGVAMGDPG...PEKIAIERVAVKY..NIPIDAVIVKMSMEEAITAMPQKVYEAADKVVEMIKRMIMERTKPGDTIILVGVGNTVGVA.
A0A5Q0UFP0_9ARCH/12-358             ......iiq-ILQILSFLLFPIL...-IVFGPRIMVWQADRKLRDVLADIEDYHNTSVNLFKENMD--V........TPEFEERLG.SM....KNFQFSAPTQLDPAGMVDRLENVLDASEDKFQRFVEK.HAD...TEDEEELADLNMAFKGVMGTQQIFKVLRHYRELINKTKNFQLVGLINMMLPIYEEMAEAQKGATRAFMDQAPIGDSIGPMVAAKLITE..EP-.--.........EEISENIMHSEEEINDQTVHVIKSDGPGSRLGKYGEAIETLAENN....--ELEAVITVDAAGKFEGEETGAVNEGVGVMMGGPG...VQKSRIEEVATEE..ELPLEGIVIKQSAPEASKPMKREIYDAYKPAVEKTKQVINEHEG---EVAVIGVGNTCGIP.
Q7LXZ0_SACS2/20-375                 ........i-LTYVLFFVLLFLL..yLPGVNTRLTVSMLARGIEGQLSMIEKYLNESKSKMEQLLKERG........VQDPKPFIE.RI....SEMFIIDPVNVEPTDIISRMRLLLRSGEDKIRDLITL.MVP...NIDNVNRSKLEVSAEVVNSLNLIYKVVRHYLILAKKLNSAILLYQLQFVVPQLVKISEAYSKAMNTFIRGIPVGDSLGPLVAAYLFMK..ADK.K-.........WNPSRDTVAGEVELEGRKLIVVKAEGPMATVGRPGEAVENVVEEY....KGKVTRIITIDAALKLEGENTGAIAEGTGVAMGDPG...PEKISIERVAVKY..NIPIDAVIVKMSMEEAITEMRKEIYQAAPKALELVKKIILERTKPGDIVVVVGVGNTAGVA.
A0A832V3H3_9ARCH/1-341              .......mv--------------...FIFLGPRIYLWQALAKIEASAQKLEKIAADGRKSVFKFSSKHGg......kSKDAKKRID.HF....MDFFMIPPVDLDPFGIMKKLEHLVRGTEDRFKKAAHE.IAP...KANSEEVMDVYMGLQAAVTINMIAKIVRHWAELMKKFKNFQFAMIFQMQLPIIEKLVEAEEKGLNAFLNGEAIGDGAGPLVIASLLDK..EGK.--.........-EIAEDVISASKKMWGHNITFVKARGPGGRLGELGDAVLKLSKRN....-RKLGKIITIDAAQKLEGEKTGSVAEGIGVAIGGVG...IERAKIEEIAVKY..NIPLDAIAIKMSPFEAISPMPTEVADSIAGATELVKERVLDTKK-GSQIIVVGVGNTCGIP.
A0A832V4V8_9ARCH/1-223              .........--------------...-------------------------------------------........---------.--....-------------------------------------.---...--------------------NMIAKIVRHWAEMIKKMKNFQLAIIFQMQMPMIEKIVEAEEKGLNAFLKGEAIGDAAGPLVIASLVDS..EGK.--.........-EVAEEVLGAEKKLWGRKLVLLKARGPGGRLGELGYAVENVLKKN....-KRVSKIITIDAAQKLEGEKTGSVCEGVGVAIGGAG...IEKAKIEEIAVSR..KLPLEAIAIKMSPFEAISPMPAEVANAVKNAVDLLWERVEETSK-GSTVIVVGVGNTCGIP.
V6AS49_9ARCH/19-371                 ........p-IMWLIWIVPIVIF..iFYG--QRIQLHVTSGEINKNIEKLLKFRDESKKEMLDHLKKSLq......vSGDVEKSVE.RF....IEYFTIMPVDIDPNGIMPKIKHLMRSREDYTRLQVKM.LCG...TDNSHELSKVQNLLEVVTSLHLLHKIVRHLFLTAKKQNNFPLILPLQMMLPFIMEQAAALRGAVSALRQGQPIGDGIGPMVVGKMMLG..LEK.K-.........-SIAFETVYAQGEFEQRVLQLLKAEGPLATVGRPGDAVEIIVGEK....--RPDIIIMIDAALKLEGESSASIAQGFGAAIGGIG...TDRFQIEEVATKH..KIPIYAIVIKQSIKEAITLMTKEIAERADEVESEVYRTIRESTTPGQTVLVVGVGNTLGVP.
A0A0P8Y3U5_9ARCH/20-372             ........p-IMMLIWIIPIILF..vFYG--QRIQLYITSSEIKKGIKKLYGFKVESRKELIDYITKTLk......pKDDPTKKID.RF....LDYFTILPVDMDPNGIVDKVRHTVRSREDYTREQVKS.LFP...EISDFELTKIQTILEIASSLQMIYKIVNHMFLTAKKQNNYPLILPLQMILPFVMEQAEAMKEAIPAFKAGQPVGDGIGSMVVGKMMLE..CEK.E-.........-TIAFQTVLAKTEFEARTLFLLKAEGPSSTVGRLADALETIVSSN....--KLDAIIMIDAALKMEGEDSASIAQGFGAAIGGIG...VERFQIEAIATKN..NIPVFSIVVKQSVKESITLMTKEIANQADDVRLQVYEMIQESTKQGQSVVIIGVGNTAGVP.
F4B6R7_ACIHW/24-379                 ........l-LYMLFFIVIIAIS..fIPGLQQQYQMMFMSKDVEKNLNTIENYLKDAKGIAEKLLKEKN........FQDPKAFLD.RV....IDRFVIDPVSIEPTDIISRMKLLLRTNEDTVRQMITK.YSP...NIDPMSRSQIEVSIEVINALNMIYKVIRHYFLLAKKLKNLMIMYQLQAVAPIYAKLAEAYGKAQKVFLQGIPVGDGLGPLVASRFLMN..IND.K-.........WSPSKDTIAGSMEFEGRKLIVVKAEGPMATVGEPGEAVQNIVEKE....GNKVARIITVDAALKLEGEETGSIAEGMGVAMGDPG...PEKIAIERVAAKY..NIPIDAVIVKMSMEEAITEMRKEVYEAADKVVNYVKNIILERTKPGDTVVLVGVGNTVGIA.
A0A650CPI3_9CREN/25-380             ........f-LAYIVFFALIALM..sLPGFQQRMYIYFASREIENSLAKIEKSLNTAKSKTKQLLEKQG........ASNPEELTK.RF....ADMFTIDPVSVEPTDIISRMRLLIRTSEDKIKSIIMT.TLP...NVDPVTRSKIEVSAEIINGLNNIYKVIRHYLLLGKKLNSYFILLQLQSVVPILVKMVEAYEKAQDTFIQGVPVGDSLGPLVASRFLML..IPE.K-.........WSPSREVIAGETLFEGRKLIVVKAEGPMATVGTPGEAVEKIVEKE....NGKVARIITVDAAAKLEGETTGEIAEGTGVAMGDPG...PEKIAIERVAVKY..NIPIDALIVKMSMEEAITSMPQEVYEAADKVVELVKKLILERTKPGDTVVLIGVGNTVGVA.
Q8TXZ0_METKA/10-360                 .....lven----LVYFIVSIIL...FWLFIRVYYQVVLFRRIEGEVERIRKIDEKVQQMVVRRAR-CD........REEAETLVQ.RA....ANLFVVQPVQLDPHGIIERLENLIERSEDKFRSYARV.LTG...KRDGVEVDNMSMALTCVFSIHVIAQYLRHLLLSAKKTNNIQLLLLITMLLPTFKQFVKSNYEGAKAFLKCVPIGDSVGPMVAARLIG-..-DS.PV.........REVEKGTVAAEKELEGRRLLIVKAHGPGGNLGRLGRAVKKLVREY....-GDVSKIITIDAALKLEGEKTGKVSEGVGVAMGDPG...HESYKIEQIAADE..GIDLDAVAIKMSATEAVMPMPKSVVDAVEEAAERALELAKEAPEDS-TVIIVGVGNTVGIP.
A0A550D237_9CREN/1-231              .........--------------...-------------------------------------------........---------.--....-------------------------------------.---...----------------VNSLNLIYKVIRHYLIMAKKLNSVILLYQLQFIVPQLVKISEAYSKAVNTFVRGIPVGDSLGPLVASYLFMK..ADK.K-.........WNPSRDTIAGELDFEGRKIIVVKAEGPMATVGRPGEAVSNVIEEY....KGKVSRIITIDAALKLEGEKTGSIAEGTGVAMGDPG...PEKISIERVAVKY..NIPIDAVIVKMSMEEAITEMRKEIYQSASKALELVKKIILERTKAGDIVVVVGVGNTVGVA.
A0A2H1EJ03_9ARCH/25-377             ........p-LMWLIWILPIFIF..mLYG--QRIQLHVTSSEINKDLEKLKQYRDDTRKELISYVKNTVk......pLSDPAVILD.RY....FEYFTIMPVDMDPNGIVPKIKHIMRTREDTTREQVKN.LAP...NITHLQASQIINILEAVTTLHLLYKMVRHFFLTAKKQNNFPLILPLQMMMPFIMEEADALKTAISAFKQGQPIGDGIGPMIVGKMMLD..TEK.K-.........-SISFETVLSEKDFEGRKLCLLKAEGPTATVGRPADAFEKIISEK....--KVDMLIMVDAALKLEGEDTGSVAHGFGAAIGGIG...TERFEIEGIATKH..NIPIYAIVIKQSIKEAITLMKKEIADSSDKVFIQIQDIIRENSKPGQCVLIIGVGNTLGVS.
A0A832XFM7_9ARCH/12-362             ......wgt---IVNWTILLIMF...-MYVLPKLYLYQIFSKLEMAAQKFEAISKKGQGLIVKKTAPFGr......aKKDIRERVT.RF....VDFFIVPPVNLDPFGIIKKLDHVIDNSDTRFRRAADY.IAP...DADSEQKMNVFMGMQAAVMINMVAKIVRHYVEMTKKFKNLQFAMLLQMQLPMLEKMIESELKGLEAFLNGHAIGDGIGPMVIASQLDT..EGK.--.........-EIAKEAIATTKTVNGRRITFVKATGPGGRLGKIGEAVEKIAAKG....--KIARIITIDAAQKLEGEKTGTISEGVGIAMGGAG...VQRYKIEEVATKY..RLPMDAIAIKMSPFEAISPMPEKVVDSLNDAVDMLNERIAEVPK-GQHIIVVGVGNTCGIP.
A0A5B9DGH1_9ARCH/14-388             .....fltt-----FFIILLLLV..fFYG--QNWQGWYAGQQIKKSLKRLNKWKKHGINLIQNIIEPRSse...gitPREITEFIN.KM....LDFFVIPPSQLDPP-IYEKLRYVMSYREERLSQLIKQ.FLP...NIDRSSLATISALLNATTEIHNLHKKIRHNLIIGERTKSYLFLLSSASDLTQMMVKARAYRTALDSFKDKQPIGDSIGPLSVNEFIKE..IQK.NNraldlernlHERSNGIYSSEISYENRKCVCLRPKGPDAIVGNIGEAVENVIIELr.ekNQHPSIVITVDAMTRLEGEKLGTVAQGLGIVIGGDShnmIEKFQIETLCMKEspSIPFEAVVCRESLEEAVSPMSEPIKLAIPKIIRTLKKIIRSQTKPNEIVLILGIGNAIGVS.
G4RQ34_THETK/15-371                 .........IITTIIWFAAIYIY...----QEFYYIQRPLWQIGGFLSYLGQMIRSASNDIGNHLERLKrq...gvgRKDVDDVIK.RM....LDFTVIPPTSLDPFGIVPKYKNILNAYETAAESEVAK.LVG...-DNTVSVKNVSTALEALREINFLYKIVDHYYRIARKYKLYVYAMQLSMLLPILKEVSDALNGAVSAFLKGLPVGDSAGPMVAYNVSKT.cSQP.IV.........HDGIKDTSITECDFEGRRLFIIKARGPGSTVGRPDEGVEFVFEKL....GVRPKYIITVDAALKLEGERTGDIAEGVGVAMGGVG...AEKFNIEGIATKY..GVPLYAFLIKMREAEALTAMTKEIYEAVQMVSKRVVDFLREKTQPGDAVVLVGVGNTVGVA.
A0A060HP75_9ARCH/36-392             .....lvwv---YIISLAIIPFF..mMY--GQKMQSKVILGEVSKSLVKLKDMKDGARRDAIDYVKSVIq.....dkAADPSAKID.KF....LEYFTIMPVDMDPSGVVRKVEHVIRTKDERMRAEVRK.ICP...GVGDYELSKIENILEAATALNMIYKVVRHYFLMGKRTTSMFVLVQLQMVMPLLIEEATAMKKAMGAFEKGQPIGDGIGPMVVGRMMLG..KEK.M-.........-PAAKETVYAEGEHAGRKLYLLKAEGPSGTVGRPGEAISRLVGDL....GIKIDAIVMIDAALKLEGEKTGDVAEGIGAAIGGIG...VEKYQIEEVATRF..EIPLYAVIVKQSVQDAITVMRKEIADSFAKVTDTVHAIIEDKTEEGQSVLVIGVGNTMGVA.
A0A510DXD3_9CREN/30-387             ..lntlffv----AIFLFYMLLA...LPGPGTKINMMFLSRGIEAQLSQIETYLKDSKKKMQEVLASKG........VQKPDEVID.RV....SEIFTIDPVSVEPTDIIGRMRLMLRTTEDKIRDIMEL.SAP...NIDPVTRSKLEVSAEVVNTLNMIHKVIRHYLLSAKKTNSIFILYQLQMVVPQLVKLSEAYSKAMNTFMKGIPVGDSLGPLVAANLLMN..SQN.K-.........WNPSRDTVAGEVEYEDRKLVVVKAEGPMATVGRPGEAVANVIEEY....KGNVKRIITIDAALKLEGEDTGSVAEGTGVAMGDPG...PEKIAIERVAVKY..GIPIDAIVVKMGMEEAITEMRKPVFDASSKVMDMLRRIIQERTKPGDLVVVVGVGNTSGVA.
E1QSZ1_VULDI/25-393                 ........f-ISTIIWLIIFVLL..lTPYFQNYMAIMWYSYSVGNFLTSLSRLIMNNVNLVINHINQLLksn..gssQSTNKSLVE.KTiqdlMEFVVIEPVSAEPTGLMRTLKLLVTSYNEKLEDSIRT.LLP...NIDRPLVQNVVDAVDGLRELNYIYKVIMHYYRLSNKYKNPYLMMQVYMLLPIIREYVNALNGAITTFLKGQPVGDAAGPLTAYRFMRGcsGLT.EL.........THNIKDTYIGLCDFEGRRVYVIKARGPGGTVGNLDDGIIYLIERV....GVKPRMIITVDAALKFEGEKTGSIAEGIGVAMGGIG...VERFNIERTASKY..GIPLYAILIKMGLPEALSAMTKDVEGAVNEAVERVKRVIRESVREGEEVILIGVGNTGGVA.
Q8ZX58_PYRAE/14-368                 .........IISMLIWFALIFML...-----QDLQMWRYLSQVSGFLSYLGQLLNAASANVLNALDKVKrk...evqRAELESTLK.KM....VDFAVIEPTALDPNGIVPKFKHILNTYVDTYEGEIRR.LVE...--DGVLVKNLTTAVEALRYMNFIYKIVDHYYKTARKYKAFYLVIQLTMLLPLLKELTDTVNEAVNSFIKGVPIGDSAGPLVAYNVLSQ.cGGV.VY.........HHDVKDTVVAECEYQGRKLYVIKAKGSGSTVGRLDEAVEYVFQRL....DARPKYIVTIDAALRLEGERTGEIAEGIGVAMGGVG...VEKFNIESYATKY..GVPLYAFLIKMRQSEALTTMTSDIYNAVGQTTKRVLDFILNNVAPGESVLVIGVGNTVGVG.
I0A172_FERFK/11-368                 ........a-ISQLAFLIVFLLL...FLGFNQRFQIYISSRNIKLKLNILEKMALDSQNKTINFLKGLG........LEKPEPVVE.RG....INYFVIDPVNVEPTDIIKRMDILFKTREDRIEGLLEQ.VVP...KASKVEKSIAVTALEIASALTLVFKYVRHYLITGQKTNNWILIMQLEMILPMLIKQAEAYSKALDVFLEGKPVGDGAGPLTVFKLAGP..NAQ.P-.........VEIVKDTVYFETIIENRKAYLIKASGPESNVGHPGFAVESLLNKLvneeGKKVGMIITVDAALKLEGEPTGEVTEGAGAAIGDVG...PEKIRIERAAANY..GIPLHAIIVKMSMEEAILTMKKEIVDAIDKVTERIKELVKNIPEDS-IIIIAGIGNSCGI-r
A0A0U2VCQ6_9CREN/12-366             .........IITQLMFMAFLLMA...FTGADQRFRMYIWARNIKSKMDEIKEMSDKSKKDTIDFLKKIG........VKRAEEIVN.EL....TEFFTINPVDIEPTDITKRMAHIFRTSLLEWERKLEEgAVE...EIPKHVKHNALVLIEIANSLNVIYKVIRHYLLYALKNNNLFLIMQLWMIMPQIVKMSKTLDKARETFKHCRPIGDSVGPLVAYKLLER..KKR.L-.........WHPAKDTVAGEVEIEGRKVIVVKAEGPGATVGNPGEAIKKVIEGM....RGQVDLIITVDAALKLEGEESGSIAEGAGAAIGDPG...PEKIAIERVATRY..NIPLQAIVIKMSNEEAITDMTKKIAMAADEAVKRVIDKVKSLPEK-SVVLVAGIGNTCGVA.
A0A6N0NPU1_9EURY/16-367             .....qiyq-ILMIISFLIFPAL...-IIFGPRLMVWQVDRKMKDVLFDLEAYKESTEAMFLDKLTSDP........NPGLKDKMN.SL....KNFQMSAPTNLDPAGMVQRLEHVLDTSESKFRRFVEN.QAD...TEDEEELADLTMAFKGVMGTNQIYKVMNHFRQLIKKTQNFQMVGLVNMMMPIYKEIAEAQKEATRAFVNQAPTGDGIGPLVAAKLIES..DEE.P-.........EEVAEDIIKSEEEIDGNKVHVVKSRGPGARLGKYGDAIDTLAEEN....--DLEAIITVDAAGKFEGEDTGAVYEGVGVMMGGPG...VEKSKIEEAATDH..DVPLEGVVIKQSPPEASKPMKKEIYEAYHEAVDKVNEIVGEYDG---EVAVVGVGNTCGVG.
W7KXZ3_9CREN/28-383                 ........f-IIYILFLGSFVLA..fFPGFQQRSQLWFISRDVEQKLSMIENYLKDSKSVSEKLLKDKG........IPDPKAFLN.RV....IERFVIDPVSIEPTDIISRMKLLMRSNENTVREMITR.LNP...NIDPVSRSQIEISAEVTMALNQIYKIIRHYLLMAKKLNSIMIMYQLQMVAPIYVKLAEAYDKAQKVFLQGIPVGDGLGPLVASRFLMK..ASH.K-.........WTVSQDTIAGIVEFEQRRLIVVKAEGPMATVGTPGEAVQNVIEKE....EGKVARIITVDAALKLEGEETGSIAEGMGVAMGDPG...PEKIAIERVAVKY..NIPIDAVIVKMSMEEAITEMRKEVYEAADKVVDYVKNLILERTKPGDTVVLVGVGNTAGIA.
A9A366_NITMS/20-372                 ........p-LMMLIWILPIVIF..iFYG--QRIQLYVTSGEIKKGIKKLDGFREESRNELITYINKHLs......pKNNPEKKID.QF....LEYFTIMPVDMDPNGIVEKVQHTVRSREDYTREHVKS.LFS...EINEIELSKVQTLLEIASSLQMIHKIINHMFLTAKKQNNYPLILPLQMILPFIMEQAEAMKEAIPVFKTGQPVGDGIGPMVVGKMMLN..SPK.E-.........-IISFQTALAQTTFENRNLFLLKAEGPGSTVGRPSDALQSIVSKN....--KIDAVIMIDAALKMEGEDSASIARGFGAAIGGIG...TEKFHIEAVATDN..QIPIFSIVVKQSVKEAITLMTKEIADQADDVRSQVYEIILENTKEGQSVVVIGVGNTIGVP.
A0A2U9IF47_9CREN/29-384             ........t-LLYIVFIGSFVLM..fFPGFQQKSQVWFLSRDVEQKLTMIENYLKDSKSVSEKLLKDKG........FPDPKSFID.RV....IDRFVIDPVGVEPTDIINRMKLLIRSNEDTVRDMITR.IQP...NIDPVSRSEIEVSTEVMSALNLIYKVIRHYLLMAKKLNSIMIMYQLQMVAPIYVKMAEAYDKAQKVFLQGIPVGDGLGPLVASRFLMK..TDN.K-.........WTASKDTVAGALEFEQRRLVVVKAEGPMATVGTPGEAVQNVIEKE....GGKVTRIITVDAALKLEGEDTGSIAEGMGVAMGDPG...PEKIAIERVAVKY..NIPIDAVIVKMNMEEAITEMRKEVYQAADKVVEYVKNLILERTKPGDTVVLVGVGNTAGIA.
A0RWY9_CENSY/11-355                 ........a-LMMLVWIIPIILF..vFYG--QRIQLYVTSNQIKKDVAKLLKYRDESEGALAEFAGGPG........------GMS.GL....LDYFTIMPVDMDPAGIVPKLRHIVRSREDLTRARVKS.MHP...GADELEISRMLTLLEIASVLRLLHKTVNHLYLTAKRQNNFPLILPLQMALPFVMEQAEAFRDAVPAFRAGQPVGDGIGPMVVGRMMLG..AAK.N-.........-EAAFQTVWAEAKSEGRWLYLLKARGPESTVGRLGEAAKSIIEQR....--RPDAVIMVDAALMMEGEESASVARGFGAAIGGLG...IERFEIEEAAAAA..GIPVYSIIVRQSAKEAVGLMPKSVAEAADGVRVQLLEMIRDSTTEGEAVLVIGVGNTAGI-s
A0A830GZK2_9CREN/25-390             .....llfn---LLLFIVYFGVF...-PFLYEYLQLMRFQMQVNGFLQQLNATITNGISQFMGAVNQIGskngssidGEKVKNELR.NL....MDLVVIDPTNIETEGLVRKLKYLINMYSDRLEGDVRM.IMP...GLDKPMVQNMANAVEVLRNLNYIYKVVDHYYKLSSKYKSYYLLYQLTFMLPFLKEAVNALSNSITSFVKGQPIGDAAGPLTIYRFMNScqGKS.SM.........DNVVPDTYIGQCLYNERKIYLMKAQGPGGTVGHLDDAVNYLLETL....NVKPRLVITIDAALKLEGEKTGTITDGLGVAMGGIG...AEKFNIETTVSKH..NIPLYAILIKMSEMEALNTMTKQIDDAVNSAVDRLKKIIEVYTSKGDEVLVIGVGNTIGVA.
F9VP55_SULTO/21-376                 ........i-IGYFVFFLIIILL..sLPGFQQKMYIYFVARDIENGLLKLENFSKNAKKKTVELLKKNG........AVNADELTE.KF....AEWFTIDPVNVEPTDIISRMRLLIRTSEDKIKQLIML.SLP...NLDPVTRSKIEVSAEIVNALNMIYKVIRHYLILGKKLQSYFILVQLQSIVPMLVKMAEAYEKAQDVFLKGIPVGDSLGPLVASRFLVN..ISE.K-.........WSPSREMIAGETEFEGRRLIVLKAEGPMATVGTPGEAVENVVNKL....GGKVSRIITVDAAAKLEGEQTGSIAEGTGVAMGDPG...PEKIAIERVAVKY..NIPIDALIVKMSMEEAITEMPKEVYEAADKVVEMVKQLIRMRTQPGDTVILVGVGNTVGVA.
#=GC seq_cons                       ........h.l..llallhlhlh...h.shtp+hQlhhhtpclcppLpplcphtccucpphhchlcphs........tp-scphlc.+h....h-aFsItPVsl-PssIlp+hc+llcsp-cph+phlpp.hhP...shsphphuplpshlElssuLNhIYKllRHahlhu+KhpNhhLlhQLQMhhPhlhchu-AhpcAhssFhpGhPIGDulGPLVAu+hhhs..spc.h...........csuc-TlhuctchEGR+lhllKAcGPuuTVG+PG-AVppllcch......+lshIITlDAALKLEGEcTGslAEGhGlAhGssG...sEKhpIEclAsKa..sIPl.AlllKMShcEAIosMpK-IhcusccslchVcclIcEpocsGssVlVlGVGNTsGVu.
//