#=GF ID   DUF1673
#=GF AC   PF07895.15
#=GF DE   Protein of unknown function (DUF1673)
#=GF AU   Fenech M;0000-0001-7933-4617
#=GF SE   Pfam-B_4746 (release 14.0)
#=GF GA   30.40 30.40;
#=GF TC   31.00 32.80;
#=GF NC   29.70 29.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR012874;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family contains hypothetical proteins of unknown function
#=GF CC   expressed by two archaeal species.
#=GF SQ   32
#=GS A0A0E3NUA2_9EURY/6-205  AC A0A0E3NUA2.1
#=GS Q8THM0_METAC/6-207      AC Q8THM0.1
#=GS Q8THM8_METAC/3-199      AC Q8THM8.1
#=GS Q8THM5_METAC/1-189      AC Q8THM5.1
#=GS Q8THM7_METAC/3-237      AC Q8THM7.1
#=GS Q8THM6_METAC/1-191      AC Q8THM6.1
#=GS A0A062V5T2_9EURY/3-195  AC A0A062V5T2.1
#=GS Q8THM1_METAC/6-206      AC Q8THM1.1
#=GS A0A0X3BNM2_9EURY/4-215  AC A0A0X3BNM2.1
#=GS Q8PXK8_METMA/6-111      AC Q8PXK8.1
#=GS L0HCW7_METFS/3-195      AC L0HCW7.1
#=GS A0A0E3NTT7_9EURY/6-206  AC A0A0E3NTT7.1
#=GS Q8THM2_METAC/3-202      AC Q8THM2.1
#=GS A0A0E3NWB7_9EURY/5-201  AC A0A0E3NWB7.1
#=GS A0A0E3L098_9EURY/3-198  AC A0A0E3L098.1
#=GS Q8PXK9_METMA/3-205      AC Q8PXK9.1
#=GS Q8PXL0_METMA/4-206      AC Q8PXL0.1
#=GS Q8THL7_METAC/2-221      AC Q8THL7.1
#=GS E1RDE7_METP4/4-223      AC E1RDE7.1
#=GS Q8THL6_METAC/7-230      AC Q8THL6.1
#=GS A0A0X3BP20_9EURY/3-193  AC A0A0X3BP20.1
#=GS A0A0E3L5Q1_9EURY/3-162  AC A0A0E3L5Q1.1
#=GS Q8PXL1_METMA/6-204      AC Q8PXL1.1
#=GS Q12Z87_METBU/4-198      AC Q12Z87.1
#=GS Q8PXL3_METMA/3-235      AC Q8PXL3.1
#=GS A0A0E3NTL1_9EURY/2-225  AC A0A0E3NTL1.1
#=GS Q8THM4_METAC/6-205      AC Q8THM4.1
#=GS Q8THL5_METAC/1-192      AC Q8THL5.1
#=GS I7LN39_METBM/3-194      AC I7LN39.1
#=GS A0A0E3NTW3_9EURY/3-207  AC A0A0E3NTW3.1
#=GS Q8THM3_METAC/1-195      AC Q8THM3.1
#=GS Q8PXL2_METMA/3-204      AC Q8PXL2.1
A0A0E3NUA2_9EURY/6-205             ...v-AFEQIKKLMGWCPNAKTAEAGPRISSVNFEA--YDRSGEEKARSPTV..PSQHSR....LDTQLLL..LPIFFTPVY...INLF-.QKGI......NTEAFLL.....GLS......................LSLPIYLLGWKKQMHQYN---..-AAKKKPVVSPSFRKSLF............................................CVILFLFLGFTLLIASLPYISSH.AAHLLND...rTLNSFASG-TLIPMWGFYFQLIYWERKNHMKMYMKREKG.qQKLYALGE-k.........................................
Q8THM0_METAC/6-207                 ...v-AFENIKKLIGWCPNARSHETQHSLHPEYFDANIPTRGGDTG--NSEN..LSWFRK....SSSKILL..VDSFLTLTY...LLVMT.QLGV......NIVTLLA.....GFF......................LSLTFFIFSWKKQMQRYD---..-TLAQKLVLDDSNKKILY............................................---KRLFRIITLIFYATLFYWIF.AGDLERNflmkGTLSFFAG-GLAFMWLGYLQILYWEKKNHKTIYFDKGYGkwKNSYIIRER..........................................
Q8THM8_METAC/3-199                 ....VFIKSIRKLMGWCPNAKALETRHSICPEYLEADNQSRGKDAGNNPILP..SGWWNK....RHNRSLI..ASSVFTIFS...LYWIT.FQGEslkneaFILGLII.....GII......................LNPLLCIWNWR----FLDKIK..NSNKK-----VRTKNKLM............................................-----TIAGILGLTTLLIESSSR.GGEFVL-....TFSLTCASGFCLTAFLYYLTDTYWEKKNKKIVLLEGYYA..PEIYVINKD..........................................
Q8THM5_METAC/1-189                 ....---------MGWCPNARAHETRKYVDLERFDLDTPAGAGGEG-GDMKN..PGRLRK....ASTRILL..YGIFFTSVC...FLVLN.QTGI......NPIFLLA.....GFF......................TALVHVAFYWKIQMEKYD---..-ALVKQSIIEHLDKKKSI............................................-ILTIPYALYFVLFFLSIIVGRE.HS-P--Q....AMISFGTG-LMVGIWLGYFQIIYWEKINHVTIYFDKGYGmgKKSYIVRE-g.........................................
Q8THM7_METAC/3-237                 ....MTLEYIKKLMGWCPNAKAFETRRSVCPEYLEADNQSRGKDAGNSPVPS..PGWWNK....RHNRSLI..DSSVFTLFS...IYLIG.FQGVspvderFMSGVIL.....GII......................FNLSLCIRTWS----YLDDIK..NSSRQRKIITVSSKEKIIkliniiialvil....................yllfsqfnwgfvLFLISAFCLIALLYYFKFDFSPM.VFLFYLGspntVFSSGIAG-ICLTAFLYYLTDVYWEKRNGKIVLVYDRKM..SEICIVNA-e.........................................
Q8THM6_METAC/1-191                 ....---------MGWCPNAKKLETGPRISSSNFEA--YGRSREEKSRSPEV..SGPHSR....LYTQLLL..LPMFFAPVY...INLF-.QKGI......NTEAFLL.....GLL......................LSLPIYLLGWKKQMHQYD---..-AAKEKTVISPSFRKTFF............................................CVFLLPFLGLTLLIAFLPYISSH.AAYLFND...qILYSFFSG-TMILMWGFYFQLIYWERKNHVKMYVKREKG.qHKLYVLGEK..........................................
A0A062V5T2_9EURY/3-195             ...t-FSENIRKIMGWCPNAGALTIRKSVQFDDLAVNAPDSGGELT---HIT..AGWWNK....YHNRILF..NSVIATLGA...IYFFT.LSGK.....dNMNFFLA.....GLI......................AGIISSIVFGITEWRRLN--K..AAAGEFRELQITRRKKVI............................................-NYIIIFGSIAVIIFVIVFFRVK.-TGIRIS....GYYAFISG-LFLFVWTQYLEVVYWERKNRKTLIVEK---..---------tsfyav....................................
Q8THM1_METAC/6-206                 ...f-VFDQIKKLMGWCPNARAHEARQHSNLENFASELPDRASGEN-EGLKN..PGWLRK....TNTYTLL..INTFLSLAY...FLVIN.QLGInltlsaNLILLLS.....GFF......................IALFFVIFDWKKQMQRYD---..-ALVKHPVIDYSDKKLYY............................................-----ILAAVLFILIYNYYIEKQ.GLDLQ--....AVFSFVGG-LVVGIWPFYFQLIYWEKKNHKTIYFDKSYGtwKNSYIIRER..........................................
A0A0X3BNM2_9EURY/4-215             kvsg----AIRRLMGWCPNATMAGTGRR----YAALDGKVGAAGEGSREVMT..GVLVDY....VSPRFIL..LALLAFAWF...FMLFV.-TCF......LIPSLRP.....GFY......................TLASLSFMTY-AAIHLYLDRK..RAVIERFGDSVIIHRPHFrslvlegdsfrsie...............vkktylpvprwafalLMLLMIAAIFFGMVQSGRVVEPD.-FAFQ--....--VLF----------------------------------..---------avglvvflfarfyrafvslqypgylriales...........
Q8PXK8_METMA/6-111                 ...f-VFDQIQKLMGWCPACRKMTLQTE-QPCNFINT-AQISGKTGNIPEFR..TSNIIF....PANTTLV..FVLFYICIS...LLL--.RYPE......DISLFLA.....GLF.....................lLNIFYYFLYLKT---------..------------------............................................-----------------------.-------....---------------------------------------..---------leaavlvd..................................
L0HCW7_METFS/3-195                 ...r-VSEVIRGWLGWCPNAQQRTFRRDSATDTTHI--LPAGSGGD-VRTLS..FGWKNR....YRTRALA..FALCMTVVG...ISLFAiSEGD......KLGLLIK.....GLI......................GASFLFALDGIRYWTLFEDV-..RTTGRVEVIHWSRRRPIQ............................................--YLVLISSLLIIGFAILVFFGF.VPGLGLR....TLDAFLAG-FTVIGWLHLIMIIAWERQSGLQLYTD----..---------gkqiyr....................................
A0A0E3NTT7_9EURY/6-206             ...a-AFEQIKKLMGWCPACQKIEPEKE--QTFFFANQAAVSGKMGNSQDIL..TSNVTF....PANTSLF..VLLFTVGFN...VLLR-.--VE......DFSLFLA.....GLVllnaiycwlalktfntvvrtgsKSLYLRGFRLKDFEIPYE---..-----------------EiesvgayniekrskksslilcilggialcvalaypvlegdwrpvLLIISIFPIILFLL---------.-------....---------------------------------------..---------akqksryrdlntrlyikt........................
Q8THM2_METAC/3-202                 ...l-NTEYIKKLIGWCPNVRASEARRNVSFENFNSDIHERAGKEN-RDPKN..LGWFRK....ASTRPLL..IYTFFTLIY...LMVFH.QIGI......SPIFLLA.....GSF......................SSLFLSIFFWKKQMQKYD---..-ELIKKPVTECSNKRKMS............................................-LFATIFAVYFVMSYIMSYLDAN.AGELAVQ....AMISFIGG-FLVSMWLEYLQILYWERKNRKVIYIDKGYG.wKKSYIILER..........................................
A0A0E3NWB7_9EURY/5-201             ..me---QYIRKLMGWCPYAKTPENGYQIPFENFEANAWEGREKAG--TPET..LYGYRK....ASTRLLR..MNASFTFLH...PVVLA.IIGL......NRGALLA.....GLG......................ISMLFGIFDWKKQMKRYD---..-TLEKEPVLDYSGKVKLF............................................KKWHGIPGCIFLLLIFYLWYEIK.AFALM--....DLYSFVAG-TLVFLWFSYLQMIYWERKNHKKLYFKSCGT.wNTSYAVRE-k.........................................
A0A0E3L098_9EURY/3-198             ...l-NTEYIKKLMGWCPNAGAAEARRNVSLENFNSDIPERSRGEN-GDLKN..PGWIRK....TSIQTLL..INTFLTLVY...IPVIN.QLGI......NLSFLLT.....GSF......................ISLFFVIFYWKTQMKRYD---..-SLIKQPIIDYSNKKKLY............................................----NVLCYVFLILIFSLYLKSQ.ETALQ--....AIFSFIGG-IVVGMWLFYFQLIYWEKKNHKTIYFNKSYGtwKKSYIIRER..........................................
Q8PXK9_METMA/3-205                 ...l-NIEYIKKLMGWCPNARASEARRNVSCENFDSDVPERAGGEN-GGLKN..TGWFRK....SSSRILL..VDSFLTLTY...LLVMI.QLGV......NVVTLLA.....GFF......................ISLTFFIFGWKKQMQRYD---..-TLAQKLVLDDSNKKNLY............................................---KKLFRIITLIFYATLFYWIF.AGDLERNflmkGTLSFFAG-GLAFMWLGYLQILYWERKNHKTIYFDKKYGkwKNSYIIRER..........................................
Q8PXL0_METMA/4-206                 .ear----YIKKLVGWCPYAKTTGLDSRTGPANFEA--YDQSGGEKAGGPEV..LSRFSRlfsrYDVRILL..PTLFFTFYL...IILLS.QKGI......NSEAFLL.....GLS......................LSLLTYLLGWKKQMNKYD---..-ALTKKPAVVSSFKKTFI............................................WVLSVIILGLILFMVLLSHLSHM.-LHFPNA...qSMYSFIAG-AWILMWGSYLQLIYWEKENHMKIYIKSEKG.fQKMYALGE-k.........................................
Q8THL7_METAC/2-221                 ....AFIESIRKMMGWCPMKNSLGKGWQ-------EGNYPFFKMENGSIQLD..PSPVDL....RRNKILKvrYSLFDRWTV...II---.----......AIFTLII.....SLLlwiyi...........pedsflIIFSGLIMFLIPLILFLN--R..PNIAEVTSGKIIIKKPMRkplviekedv........................mqisvtrtenHYLRWLVRSIYVVFIPLYFVKEI.MPTLQEMersfPEYIDLSLFLLNLTVLVMFLVMFYNFE------LMAPYQ..-RILKVTTR..........................................
E1RDE7_METP4/4-223                 ...r-ISETIHKWMGWCPAKTAMKSSMGISGYGIRKG-------------ET..PGSPDR....ISSDRIVdyVPTWTSLLQ...FLVFG.----......TEIAAIV.....AFLkfvnk...........yypgtdILLLLCIMLVTGYLIIYSDIK..RTTIESGPDVITVKRPGFrtvhiqksdinnae................iidnhrpvpqfvlaILGLIIIPVFSVVSIYGRYVEWI.SGEI---....LTPLFIAYLGFFIVISIFFLVIYNYAR------IRKRYP..-KSFVITTK..........................................
Q8THL6_METAC/7-230                 ....AFIESIRKMMGWCPMKNSLGKRKQ-------ENNYPDFKFENGIVELG..SSPADL....QGNRIFKvhVNLFPEWWA...VIII-.----......-LFALII.....SLLlwtys...........pessflIILSEIILYL-PLIVLLLFHH..PSTVTVMPEKIIVKRLIRkpvviekkdiiqis................vtrnenrslrwpmrLVFLVTLPII-----LLRTVERI.VRDLQLEa.aaSASAKLSLFLSQSLTVTYLLVFFYYFE------IRAPYQ..-QILKMTT-y.........................................
A0A0X3BP20_9EURY/3-193             ..sl--VETIRAYLGWCPMKGSMRVDRAVQQLEVAA--APGGRDG--PLRTE..PGWWNR....YHNQLLI.tAATFSAVAAatfILVED.TLGY......--PAVWT.....GLA......................IGAGGALGFLLGYRKQYARIAagEFIRANMSRRLRIARDLS............................................--WPVALILLAVCMAYF----VR.SGMF---....GQILGFMLALSVIGWISYAVTILWERR-HRTTLIAE---..---------rgsmytl...................................
A0A0E3L5Q1_9EURY/3-162             ...l-NTEYIKKLMGWCPYAKTTGVGPRLSPDNFEAN--DRSGGEKGDRPGR..EKPLIK....RNSKQFL..ISFFVSICI...IIS--.--G-......-TASTIM.....ESF......................MNFVFVLMGFGLLLDTLS--K..SETNAKSSKLMSICSVVF............................................-----------------------.-------....---------------------------------------..---------wsamcfglhfyfkssgsivtaklfvlfgiygaakaiystvpi
Q8PXL1_METMA/6-204                 ...f-VFDQIKKLMGWCPNAKKLEAVNQNSFSNFEA--YDQSGKEKSNVSKA..SDKHSR....LDIQLFL..FPFFFTPIY...INLF-.QKDI......NTEAFLL.....GLS......................LSLPIYLLGWKKQMHQYN---..-AVKEKPVISPSFRKTLA............................................CVVLFLFLGITLLLVFLPYISPY.FYLLNDQ....TLNSFVLG-TLILIWGFYFQLIYWERKNHMKIYIKRENA.qQKLYVLEEK..........................................
Q12Z87_METBU/4-198                 ...n-IAETIRKVMGWCPNLGAMEARKAMQFDNLVVNAPDKSREPN---HKT..MTWRNK....YRNLILI..GSIFGTIGP...INMFI.SWGG.....kNMGIVLA.....GTF......................LGILISKITWKTTWHSLDRIA..IRIPRKAATKLSIKRIVV............................................-FGIIIFIYVAVITHFMSIYGLR.-------....SVVAFLGGCGMSLLWSHYMQIVQWERKNQKTL-VKSGYA..TPIVVVSN-d.........................................
Q8PXL3_METMA/3-235                 ....VFTKSIRKLMGWCPNTKTLETRHSICPEYLEADNQSRGRDAGNTPILP..SGWWNK....RRNRSLI..FSSVLTIFS...IYWVA.FQGEslkneaFIHGLIF.....GII......................CNLLFCIWNWS----YLDDIK..NSSRKIKIITVSSKWRVInlilslgsly.......................llfsefnwgfvLFLISAFCLIALLYYFNFNSAPL.VFLLYFGsfnmAVMAFILG-TCLTAFLYYLTDVYWEKKNHMKIYIIFENS.lEKIYAIGEK..........................................
A0A0E3NTL1_9EURY/2-225             ...v-FLGYFRKLMGWCPMKDSLKKERQ-------EDCLPGFKPENRSLQLS..SSPVGL....EENRILKahVSLFPGWKP...VIIIL.FAAV......SSFLLWIyshenSFL......................FILSELILYLL-LVVPLLSHF..SSTVAVMPEKLIIKRPLRkpvviekrdikqis................vpkndnhslrwtmrLFYLATISII-----LLHAVERI.NRDLQLEe.aaTFSAKLSLFLGKFLVVSFLLVLYYIFE------LRAHYQ..-RVLKVT--mh........................................
Q8THM4_METAC/6-205                 ...l-VCDQIKKFMGWCPNAKKLETGPRISSADFEA--YGRSGEEKARSPEV..LGSHSR....LYTQLLL..LPMFFTPIY...INIF-.QKGI......NLEAFLL.....GLS......................LSLLTYLLGWKKQMHQYD---..-AAKEKPVISPFFRKIFF............................................YVFLFPFLSLGLLIAFLPYISSH.AAYLFND...qVLYSFFSG-TMILMWGFYFQLIYWERKNHVKMYMKREKG.qHKLYVLGEK..........................................
Q8THL5_METAC/1-192                 ....---------------------------------------MENGSIQLN..PSPMDT....PESRIPKvqVSLFDFWAL...IITVF.---V......SIISFIT.....SLLvwayi...........pedsflIIFSGFVIFLIPLIFFLN--R..LNTVEVMSGKITIKRPLRkpvvvekedir.....................qisvtrnenhslRWLIRLFYVIFLPFYLGEGIIKA.LRNLERS...fPDYIVLSLFLVRLAGVAFFLVLYYNVE------ILAPYQ..-QTLKITT-n.........................................
I7LN39_METBM/3-194                 ..sl--VETIRAYLGWCPMKGSMRVDRAVQLEVAAA---P-GGRDG-ALRTE..PGWWNR....YHNQLLV..TALAFSAAA...AATFI.LVEDt....lGYPAVWT.....GLA......................IGVGGALGFLLGYRKQYARIAagEFIRANMSRRLRIARDLS............................................--WPVALILLAVCMAY----FVR.SGMF---....GQILGFMLALSVIGWISYAVTTLWERR-HRTTLIAE---..---------rgsmytldt.................................
A0A0E3NTW3_9EURY/3-207             ....VFIKSIRKLMGWCPNAKTLETGSRISPANFEAYAQSGGEKARNQGIQSqfSRLFSR....FDVRILL..PTLFFTFYL...INLLF.QKGV......NVETFLL.....GLS......................LSLLIYLLGWKKQMNKYD---..-TLTKKPSIVSSFKKTFF............................................RNFSVIILSLILLMVFLPYIRSHtALSLNAQ....ALSSFVAG-TWVLMWGTYLQLIYWERKNHMKIHIKSEKG.fQNMYALGE-k.........................................
Q8THM3_METAC/1-195                 ....---------MGWCPNVKTAEVGSRISPANFEAYAQSGGEKARNQGVPNrfSRLFSR....FDVRILL..PTLFFTFYL...INLLS.QKGI......NLEAFLL.....GLS......................LSLLTYLLGWKKQMNKYD---..-TLAKKPAVAPSFKKTFI............................................WVLSVIILGLILFMVLLSHLSHM.LHFLNAQ....SMYSFIAG-AWILMWGSYFQLIYWEKKKQMKIYIKSEKG.fQKMY-----aseek.....................................
Q8PXL2_METMA/3-204                 ...l-NTEYIKKLMGWCPNTKTNEARRHFNIESFDSNVPDREKGEN-EDLKP..PEWFRK....TRIQTLL..INTFFTFAY...FLVIN.QLGInltlgvNFIHLLV.....GLF......................IVLFIVIFDWKKQMRRYD---..-ALVKCPVVDYSDKKIMY............................................----YILGYLFLILIYLLYIKGY.EPSLQ--....AIFSFAGG-LIVGMWLSYLQLIYWEKKNHKTIYFNKSYGtwKKSYIIQ--ge........................................
#=GC seq_cons                      ...h..h-.I+KlMGWCPNscshcsppphs.pshpus..stuttps.ts.hs..suhhs+....hpschLl..hshFhohhh...lhlh...hGh......sh.shlh.....Glh......................luLhhhlhtapt.hppYs......shhcp.shphohK+hhh..............................................hhhlhhhlhllhhhh.hhp.h..h.l.......shhuFhuG.hhlhhWh.YhpllYWE++sphphhhcptht...p.hhltp...........................................
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