#=GF ID   DUF1890
#=GF AC   PF09001.15
#=GF DE   Domain of unknown function (DUF1890)
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1kjn
#=GF GA   25.00 25.00;
#=GF TC   125.90 125.70;
#=GF NC   22.90 20.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR012033;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in a set of hypothetical archaeal proteins.
#=GF SQ   48
#=GS E3GXM9_METFV/4-144       AC E3GXM9.1
#=GS Q8PX08_METMA/7-146       AC Q8PX08.1
#=GS Q8TUD9_METAC/7-146       AC Q8TUD9.1
#=GS U6EC93_9EURY/6-148       AC U6EC93.1
#=GS Q6LZC8_METMP/4-143       AC Q6LZC8.1
#=GS A0B5R6_METTP/7-147       AC A0B5R6.1
#=GS D7DTT0_METV3/4-143       AC D7DTT0.1
#=GS A0A8J8C753_9EURY/4-143   AC A0A8J8C753.1
#=GS O26871_METTH/10-152      AC O26871.1
#=GS G7WND6_METH6/15-154      AC G7WND6.1
#=GS F4BV71_METSG/1-130       AC F4BV71.1
#=GS A0A498H5E8_9EURY/11-150  AC A0A498H5E8.1
#=GS A0A328PAD8_9EURY/5-147   AC A0A328PAD8.1
#=GS A0A8J7W5S2_9EURY/9-148   AC A0A8J7W5S2.1
#=GS Q8TY95_METKA/3-136       AC Q8TY95.1
#=GS H1Z466_9EURY/11-150      AC H1Z466.1
#=GS L0HDF3_METFS/13-152      AC L0HDF3.1
#=GS A0A8J7W9G8_9EURY/9-148   AC A0A8J7W9G8.1
#=GS L0HI59_METFS/195-335     AC L0HI59.1
#=GS A7IA47_METB6/19-158      AC A7IA47.1
#=GS E1RIN5_METP4/11-150      AC E1RIN5.1
#=GS A0A166EUJ2_9EURY/5-147   AC A0A166EUJ2.1
#=GS A0A2V3JLR4_9EURY/5-144   AC A0A2V3JLR4.1
#=GS D3E4S8_METRM/4-146       AC D3E4S8.1
#=GS R9SK40_9EURY/4-147       AC R9SK40.1
#=GS F0TCE6_METLA/5-147       AC F0TCE6.1
#=GS A0A1V6N297_METAZ/5-147   AC A0A1V6N297.1
#=GS A0A315XMX7_9EURY/4-147   AC A0A315XMX7.1
#=GS A0A0X3BI52_9EURY/12-151  AC A0A0X3BI52.1
#=GS A0A366MG08_9EURY/5-147   AC A0A366MG08.1
#=GS A0A2U1S8F5_9EURY/5-147   AC A0A2U1S8F5.1
#=GS A2SPZ3_METLZ/5-145       AC A2SPZ3.1
#=GS Y452_METJA/5-144         AC Q57894.1
#=GS A0A2V2N6S7_9EURY/10-150  AC A0A2V2N6S7.1
#=GS A0A165Z1I2_9EURY/4-146   AC A0A165Z1I2.1
#=GS A0A162FND7_9EURY/5-147   AC A0A162FND7.1
#=GS A0A062V4B2_9EURY/1-136   AC A0A062V4B2.1
#=GS A0A1D3L056_9EURY/5-147   AC A0A1D3L056.1
#=GS Q2FRW8_METHJ/11-150      AC Q2FRW8.1
#=GS A0A8J7UR41_9EURY/11-150  AC A0A8J7UR41.1
#=GS A0A0E3P090_9EURY/7-146   AC A0A0E3P090.1
#=GS B8GH97_METPE/12-152      AC B8GH97.1
#=GS F6BA72_METIK/4-143       AC F6BA72.1
#=GS A0A483CT72_9EURY/11-150  AC A0A483CT72.1
#=GS I7KXX2_METBM/12-151      AC I7KXX2.1
#=GS A6UVE1_META3/4-143       AC A6UVE1.1
#=GS A0A1D2WA16_9EURY/5-147   AC A0A1D2WA16.1
#=GS B8GI79_METPE/15-154      AC B8GI79.1
E3GXM9_METFV/4-144                  LIMLGCPEYPIQTPLTIYTSYLLKIKNCKVSIAGNPAALNLVKISDPERRYIDKL..LNIDS--HEIEKN--KWDYLIGFISNDASATYFITFNEILN-VGSLSIVFNE.DKKE..LKELVETik.hntNSKIIQARARHNPKPLVKKIDA-f.
Q8PX08_METMA/7-146                  LLMMGCPEVPIQTSIALYLSHKLTQSGFDVTVAGTNAATKLLKISDSDGYYAKKL..VDLDKTLEDIIEKRADFDICFAFMHNDSGVTYAATVSAISQ-VRMYSIVFGR.HAEE..LAQTIEF......DCEKIVTQDVHNPVRLKNKLDKI..
Q8TUD9_METAC/7-146                  LLMMGCPEIPIQTSIALYLSHKLTNLGFDVTVAGTEAATRLLKVSDSDGYYAKKL..VNLDKTMEDIIEKRSDFDICFAFMHNDAGMTYAATMSA-LSQAKLYSIVFGR.HADE..LAETIEF......DGEKIVSKDVHNPLRLKNRLDKI..
U6EC93_9EURY/6-148                  IILLGCPESPSQTPLTIYAAHKLKNMGYEVTVASTPSAKKLVEVADPVEYYVQKK..VDIESCLDNLEEG--EFDLLLGFMAKDAAVSYFVTFYHILN-TKSLALIFHR.DPEK..LENFEDSvr.estNAEIASARAYHNPTPLRVRLDR-a.
Q6LZC8_METMP/4-143                  MIILGCPEPPVLVPAFMFLLNMLKNKGHELIVSANPAALKLIESADPEKYYLTGIgfQPIDEGLKTRT----EVDHIIGFAHNDAAVNYIVTYKMTHN-VNTSAIVFGK.EFNE..--ELLQIlt..enGVNAEMARAFHNPTPLNVKIKKM..
A0B5R6_METTP/7-147                  LLLMGCPEVPVQMSLVLYLSGALRDKGLKVFIAGNPAALNLARVADRKRCYLGRL..IELERTIADIVEGRRSFGICFAFAHNDAGITYAATVRALLPEARFFVIIFGR.NAEE..LAGTVDF......DAEKIAERAVHNPLGLKKKIDEV..
D7DTT0_METV3/4-143                  LILLGCPEPPLLIPSFMFLLNLLKNKGHQVYVAGNPSALKLIESADPEHHYLKGVgfQPIDNGLKEKF----DVDYIFGLTHNDAGVNYIITYKMVYN-KDTSALVFGTgDLES..LSKILNE.....nGVENKSMRAFHNPTPINVMLKRI..
A0A8J8C753_9EURY/4-143              LVILGCPEPPLLIPSFIYLLNMLKNNRHEVIISANPAALKLIEASDPEKYYLKGVgfQNIDEGLKNKF----DVDGIIGFAHNDPAINYIITYKAVYN-EKTFALVFNK.DINQefVRNLEEE......GVITFTARAFHNPMPVLVKLKN-i.
O26871_METTH/10-152                 LMVLGCPESPVQIPLAIYTSHKLKKKGFRVTVTANPAALRLVQVADPEGIYTDEM..VDLESCINELAEG--DYEFLAGFVPNDAAAAYLVTFAGILN-TETLAIIFDR.DADV..LEELVNEim.etlDAEIIAARAHHNPAPLRVRIDR-f.
G7WND6_METH6/15-154                 LILLGCPEVPVQTSIALYLAYRLRERGDEVVVAGTGAALKLTKLADPLGHYLGET..TNIDRCIASISEGKADFDQCFAFAHSDAGITYAGTISYISR-ALLFVLIFGR.SAEE..LAETVEF......DCRKLVAKAVHDPLPLKRLLDEV..
F4BV71_METSG/1-130                  ----------MQISIVIYLAHKLKKEGWDVTVAGTNAPIKLLKTADPEGYYVQKT..ADLDWIIQEIVEKKMDFDACFAFMHSDAGMAYGATFSAISK-AVHYAVVFGK.NAEA..LGESIDY......PTEKIVAKATHNPGPLKSKIDKV..
A0A498H5E8_9EURY/11-150             LILLGCPQVPVQTSVALYCAYMLQQNGIRPIIAGTTAARKLLEVADPERHYAGTL..EDLDTVIGEFAEKKRDVDYCFVFAHNDSGIAYAGTMAY-LSKARLYVLLFGE.HPEE..VAAAITF......PCEQVTVKATHNPMPMKKKIDEV..
A0A328PAD8_9EURY/5-147              LIFLGCPESPIQAPLALYLSHKLREKNYGVTVTANPATLRLLEVADPARSYLDKT..SDLDSTLDSLSKG--EYDLLFGFIHNDAALTYFITFKSILE-IPSIAIIFER.DAKI..LNTLEKEvk.entDSHIVSARAHHNPNPLKVRIDK-l.
A0A8J7W5S2_9EURY/9-148              LIMLGCPEIPVQQALALYAADRFNDDGWDLTIAGNGAVLNLLRVSDPKKVYIRKM..MDLEKCIDELSAKERAPDLCMVCIHNDAGLSYAASIRYLFE-GRFIALVFGR.DAEA..LAAEIDF......PCDPVVDVAVHNPGKLRRKLDEV..
Q8TY95_METKA/3-136                  VVSLGCPKIPPKISSAIYACYRYDDRA---LVLSTEAGCKLLEYADPEKEYVDET..RTYEKYLEDPD----AAGILLAFVTNDTELQIAVTLKEVSEPDDARAVCTEE.FEDR..LEDCGFL......TAPVTGRRWKHDPKRWVKAVEDV..
H1Z466_9EURY/11-150                 LLVLGCPQVPTQTAAAMYLAYKLRNAGIRPVIAANPAARMLMKYADPEKHYIDEL..HDLDKMIGDLVEKRQEFSLCFVFVHNDSGLSYAASMNIILNGGVVIPVIFGK.EIES..LKEGINF......ECSVISGRAEHNPKPLINAME--s.
L0HDF3_METFS/13-152                 LLVLGCPQVPVQTSIALYLINRLKKAGISPVVAGNKAANTLLVVADQDRHYLGEV..IDLDRAIGLITDGKRTFDLCFVFIHNDAGVSYAATMGAISK-AKLYGLVYGE.HFEE..QAKKIDF......PCTVVAAKAVHNPLPLKKAIDEV..
A0A8J7W9G8_9EURY/9-148              LILLGCPEVPVQQALALYAADRLNEAGKDVLIAGNSAVLVLLKVSDPKKVYAKKM..VELDRCIEELASGERTPSTCIVFAHNDAGISYATTIRYLFE-GRLIVIVFGR.EAEE..LAEQLEI......PCEMIVEKAVHNPGKLRKKLDEV..
L0HI59_METFS/195-335                LLVPGCPEVPVQQALALHISHNLRKRGTALTVTGNPAVLNLLKVSDPEKLYLPET..IVLEKCIEELVEKKRDCKLCIVFAHSDAGISYAATMRHLLPASRLIVIIFGK.DPEA..LAALIDF......PCEKIVDKAVHNPMQLRKKINEV..
A7IA47_METB6/19-158                 VLVLGCPQVPVQTSVALYLADKLSVAGIAPVIAGNKAAITLLVVADPKRHYLKEV..MDLDRAIAQISDKKRDFDLCFVFIHNDAGVSYAATMAAISK-AKIFPVIYGE.HWEE..MAAQITF......PCTKIAVKAVHNPLPIKKIIDEV..
E1RIN5_METP4/11-150                 LLVMGCPQVPVQTPAVLYISYKLKEEGYKPVAAGTPAADMIIKYSDPGLYYIGEL..KNIDSEVARIVDEGENYDLCFVFIHNDSGVAYAATMNEILE-CEVIPVVFGK.EYDE..MVKLIDF......SSRIISAEAVHNPKPLIKEIDRV..
A0A166EUJ2_9EURY/5-147              LLLLGCPESPSQTPMAIYASSKLSQLDYEITIASTPAASKLLEVSDPNGYYVKDK..IDIDSCLSTLEEK--QYDLLLGFVSKDAAASYFVTFYHILQ-TESIALIFEK.DPDV..LEDLTKTve.entEGKIVSVKAFHNPNPIKVRFDKI..
A0A2V3JLR4_9EURY/5-144              LLLLGCPESPVQTAIALYLANKLKRDSIDVTVAGTRSAIALLKVSDPEGNYVSET..VDLDSCIENLAEKKLDFDLCFVFVYNDAGISYLFTLSSMSD-AKLFAIVFGS.DADA..FASMIDF......ECEKIVYKTGHNPVPLKRRIDQV..
D3E4S8_METRM/4-146                  LVLLGCPEAPSQTPIGLYASYKLGQMGYDVTVSSNPAAGKILDISDPEGVYVKKR..VDIEKCLDEIEEG--DYDLLVGCVHKDAAATFFITYYHILK-CKALALVFSR.DAEE..VAEFADMve.sstDADIIAVRAFHNPNPIKVRFDK-y.
R9SK40_9EURY/4-147                  LLLLGCPEVPSQTPMAIYAISQLNDMGYEVTVSSNPAAAKLLKVSDPKNCYPHKN..VNIDRFLEDAGAK--DFDLVLGFVHKDSAATYFITYCSVMNYKKAIALVFQR.DASL..VEDYSKMvs.entDAEVVSCIAYHNPNPIKVNLNK-a.
F0TCE6_METLA/5-147                  LILLGCPEAPSQTPLAVYTTYKLKEIGYEVTVASTPSAMKLLEVSDPEGFYVTNK..VDIESCLENLEEK--EYDLLFGFVHKDAAAAYFVTFYHILN-TKSVALVFEK.DIDL..LEKFIKDvq.dstDSEIVSARAYHNPTPLRVKVDR-y.
A0A1V6N297_METAZ/5-147              LILLGCPESPSQTPMAIYVAQKLAKMDYDVTVASTPSAAKLLEVSDPEEYYVKNK..TDIESCLDGLEKG--QYDLLVGFVHKDAAASYFITFYHLLE-CESIALVFEK.DNEL..LEEFVKMvd.entDSKIVAVRAFHNPTPLRVKFDKV..
A0A315XMX7_9EURY/4-147              LVLLGCPETPSQTPMAVYVFNKLTKMGYDTTIAANPAAKKLVKISDPENYYNLNL..VDLERLLGEINEG--DFDLLVGFVHKDAAASFFVTFEQIIQ-CKSIALVFSR.DADE..VAEFVEMieesgsNALITAVRAFHNPSPIKVKFDR-a.
A0A0X3BI52_9EURY/12-151             LILLGCPQVPVQTSMALYLAHGLSQRGIRPVVAGTTAARRLMEVADPDRHYLGEM..ADLDATIDEITGKVRDFDLCFVFIHNDSGVAYAGTMAYISR-ARLYALLFGE.HAED..LVGEIEF......PCEVIAAKAVHNPMPLKRRLDEV..
A0A366MG08_9EURY/5-147              LILLGCPESPSQTPMAVYAAQKLEKIDYEVLVASTPAASKLLEVSDPDKYYIKNK..IDIESCLDNLEKD--QYDLLMGFVHKDAAASYFITFYHILQ-CESIALVFEK.DLEL..LNEFTEMve.entDAKIVSVKAFHNPTPLRVKFDRV..
A0A2U1S8F5_9EURY/5-147              LVLLGCPESPSQTPMAVYAANKLSELDYDVTVAANPAATKLVKVSDPKKVYVKSI..VDLDRCLNDIKEG--DYDLLVGFVHKDAAASFFITFYHLLQ-CESIALVFEK.DMEL..LESYVDMvq.entDAKIVAVKAFHNPTPIRVRFDKV..
A2SPZ3_METLZ/5-145                  LILIGCPQIPVQSPLVLYIADFLQDAGHHPVVAANPSAKQLVKTSDPKSHYVSEY..KDVEKAIGELADGTVQYPLIISLIHNDAGLTYTATTSAVAPKSLLISVLFGE.HAYD..LAEEIEY......PTEKVVAPVTHNTRPLLIKLDEV..
Y452_METJA/5-144                    LVIVGCPEPPALIPSVLYLTNQLKKKGFNVIIAANPAALKLLEVADDDKYYLKGVgaVDIDGGLRGIE----GINKIISFVHNDGGVSYTVTYKAKYN-KPTYAIVFGR.QINK..--DYVETlk..nsNIGVYTARAFHNPMPIVNRIKEI..
A0A2V2N6S7_9EURY/10-150             LIVLGCPEVPVQNSLAVFTAYQLRKNGYSCLIAGNPAVMKLLMTSDPEKHYISAM..TTLEKAVEDITDKGEKYDLCLAFAHSDAGISYAATMRYLLPEARFITIVFGR.SAEE..IAKLVEY......EGETIVEVAVHNPMPLKKKMSEV..
A0A165Z1I2_9EURY/4-146              LILLGCPESPSQTPMANYVSWKLSNLGWDVSVASTPAASKLLEVGDPNNQYIKNK..IDIDSTLNTLEEG--QFDLLIGFVSKDAAASYFVTFYHILK-IKALALIFEK.DLDV..LEDLTNIvr.estDAEMVSVKAYHNPTPLKVKFNK-s.
A0A162FND7_9EURY/5-147              LVLLGCPESPSQTPMAIYVSNRLNTLGYETYIAANPAALKLLEVSDPNNVYIKNT..VDIDESLNSLQEK--DYDLLVGFVHKDAAASFFVTFYHILK-TESIALIFEK.DGEL..LEEYTNIvs.kntDAKIGSVRAFHNPNPIKIIFD--sa
A0A062V4B2_9EURY/1-136              ---MGCPELPVQTAAALYLASRLNREDFDVTAAGNRAAISLLLNSDPERHYIKKV..MDIDRCIGELAQKRMDFDICFAFIHSDSGIAYLATVKA-LSTARTVAVIFGK.EIEP..LIEAGG-......DSIIIAAKAVHNPAPIRAKIDEV..
A0A1D3L056_9EURY/5-147              LILLGCPEAPSQTPMAVYSTYKLQQMGYEVTVASTPSAMKLLEVSDPEELYVKNK..IDIESCLENLEPE--QYDLLVGFVHKDAAVSYFVTFYHILN-TDSIALVFEK.DPDL..LEKFQKAvs.entDAKIVAVRAYHNPTPLRVKFDR-a.
Q2FRW8_METHJ/11-150                 VLVMGCPKVPVQTSLVLYLSNRMKKAGIRTIIAGTPSARQLIRVADPDGHYTMEM..KDLDATIAALAKGDLTVTESYVFVHNDAGVSYAATMQSLTN-QPVMAIIFGE.EAEQ..IAQEITF......PCTVIAEPATHNPMSLKNRLEE-a.
A0A8J7UR41_9EURY/11-150             LIVLGCPEAPAQVSLAVHLAHGLRRSGYVPVVTGNPSARHLLAMADPEHHYIGEM..LDLDRCIEDIAAGEHDYALTFVLVHRESGVSYAGTLSVVST-GRVIAVVFGK.EAEV..LASLIDF......ECEKVVAQVVHNPMPLKKAIDRV..
A0A0E3P090_9EURY/7-146              LLMMGCPEVPIQTSIALYLSHKLTNSGFDVTVAGTGAATKLLRVSDSDSYYVKNL..VNLDKTLKDVIEKRADFDICFAFMHNDAGMTYAATMSAL-SEAKLYSIVFGR.NAEA..LAETIEF......DCDRIIEKAAHNPVQLKKKLDKV..
B8GH97_METPE/12-152                 LIILGCPEASAQQALALHVAHNLKKRGAEVLIAGNPAVLNLLKVSDPEKHYITNT..MTLEQCIGDVIENKRDCDLCVVFAHNDAAITYAATMRYLLPERKMVVIVFGK.DPGP..LADAIQF......PCEIIVDRAVHNPMKLKTMINRV..
F6BA72_METIK/4-143                  LVLLGCPEPPVLVPSFIYLTNMLKKKGCEVFVSANPAALKLVETADPEKLYIKNVgfQEIDEGLKEAF----DVDYIISFVHNDAGVSYTITYMHKYK-AKTIGIVFGR.EMKE..--DFVNTlk..enGVEAYFVRAFHNPTPIVVTLKRI..
A0A483CT72_9EURY/11-150             LILLGCPEAPAQVSLALHLAHGLRSMGLDPVITGNPSSRKLVEMADPDRHYCSGM..IDLDACIESMATGEADYVVSFVLIHIESGVSYAGTLSAISQ-GRVVAVVFGR.DADS..LADLIDF......PCEKVVVATVHKPGPLRAAIAKV..
I7KXX2_METBM/12-151                 LILLGCPQVPVQTSMALYLAYGLSQRGIRPVVAGTTAARRLMEVADPDRHYLGEM..ADLDATIDEITGKVRDFDLCFVFIHNDSGVAYAGTMAYISR-ARLYALLFGE.HAED..LAGEIEF......PCEVIAAKAVHNPMPLKRRLDEV..
A6UVE1_META3/4-143                  MILLGCPEPPVLIPSCISLINMLKEKGCEVVISANPAALKLIESADPEKYYLKDVgaQSIDGGLKNKF----PVDLIIGMAHNDAAVNYIITYKSVYD-AKTVAMVFGK.NINNelIEDLMDE......EIPCQTAKAFHNPTPVIVKLKKI..
A0A1D2WA16_9EURY/5-147              LILLGCPESPSQTPMAVYVTYKLKKMGYEVTTASTPSAMKLLEVGDPAELYIQNK..VDIDSCIEKLDKG--TFDLLVGFIHKDAAVSYFVTFYSILD-TKSIAIVFEK.DADK..LAEFIDTvs.estDAEIVSARAYHNPTPLRVKFDK-t.
B8GI79_METPE/15-154                 LILLGCPQVPVQTSLAIYLCHALKAHGVLPTIAGTTSARKLIDVADPEGHYIGTS..IDLDACIAAIAEKERDFDEIFVFVHNDGGVSYAGTMSAISS-GRLIAVIYGE.HAEE..VAATITF......PCEKVVAKAVHNPMPLVHKLKEV..
#=GC seq_cons                       LllLGCPEsPsQTshAlYlup+LpptGaclslAusPAAh+LlcVuDP-caYlpph..hDlDpslcsltct..-aDlhhuFlHsDAuloYhsThptlhp.s+slAlVFG+.-s-p..Lschlch......sschlss+AhHNPtPL+h+lDcl..
//