#=GF ID DUF2016
#=GF AC PF09436.14
#=GF DE Domain of unknown function (DUF2016)
#=GF AU Mistry J;0000-0003-2479-5322
#=GF SE Iyer L
#=GF GA 24.10 24.10;
#=GF TC 24.50 25.70;
#=GF NC 23.80 23.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 16859499
#=GF RT The prokaryotic antecedents of the ubiquitin-signaling system
#=GF RT and the early evolution of ubiquitin-like beta-grasp domains.
#=GF RA Iyer LM, Burroughs AM, Aravind L;
#=GF RL Genome Biol. 2006;7:R60.
#=GF DR INTERPRO; IPR018560;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC A predicted alpha+beta domain that is usually fused N-terminal
#=GF CC to the JAB metallopeptidase. This protein in turn is found in
#=GF CC conserved gene neighborhoods that include genes encoding the
#=GF CC bacterial homologs of the ubiquitin modification system such as
#=GF CC the E1, E2 and Ub proteins [1]. The domain is also known as the
#=GF CC JAB-N domain.
#=GF SQ 64
#=GS A0A4V3BPJ2_9BURK/4-76 AC A0A4V3BPJ2.1
#=GS A0A0Q6W4E1_9BURK/5-76 AC A0A0Q6W4E1.1
#=GS C5T055_ACIDE/7-78 AC C5T055.1
#=GS Q8XYU8_RALSO/53-126 AC Q8XYU8.1
#=GS A0A562BRU2_9BURK/4-76 AC A0A562BRU2.1
#=GS N6Y9C8_9RHOO/4-75 AC N6Y9C8.1
#=GS A0A346B7E1_9BURK/53-126 AC A0A346B7E1.1
#=GS A0A3D8K211_9BURK/53-126 AC A0A3D8K211.1
#=GS A0A518U8F0_9PROT/4-75 AC A0A518U8F0.1
#=GS A0A328Z754_9BURK/4-75 AC A0A328Z754.1
#=GS Q120V3_POLSJ/3-73 AC Q120V3.1
#=GS A0A0H3KQT7_BURM1/1-51 AC A0A0H3KQT7.1
#=GS A0A1D9HCL7_9BURK/4-76 AC A0A1D9HCL7.1
#=GS A0A139BN16_9PROT/4-75 AC A0A139BN16.1
#=GS W0SFK5_9PROT/4-75 AC W0SFK5.1
#=GS A1VVA1_POLNA/3-75 AC A1VVA1.1
#=GS A0A069NS28_9BURK/4-76 AC A0A069NS28.1
#=GS A0R7L0_PELPD/5-76 AC A0R7L0.1
#=GS A0A1D9HD39_9BURK/4-76 AC A0A1D9HD39.1
#=GS A0A7Y8GY46_9BURK/6-77 AC A0A7Y8GY46.1
#=GS A0A1E3LXB5_9SPHN/13-83 AC A0A1E3LXB5.1
#=GS A4JUM8_BURVG/4-76 AC A4JUM8.1
#=GS A0A6S6Y1E3_9PROT/4-75 AC A0A6S6Y1E3.1
#=GS A0A1E4QXH3_9BURK/4-76 AC A0A1E4QXH3.1
#=GS A0A1D8KCM5_9GAMM/10-86 AC A0A1D8KCM5.1
#=GS A0A7H0GK40_9BURK/7-78 AC A0A7H0GK40.1
#=GS A0A2N8K9T7_9BURK/4-74 AC A0A2N8K9T7.1
#=GS A0A0F7JUM1_9SPHN/13-84 AC A0A0F7JUM1.1
#=GS Q5NXB5_AROAE/4-75 AC Q5NXB5.1
#=GS A0A1Q8IKJ1_9BURK/4-76 AC A0A1Q8IKJ1.1
#=GS A0A0Q4XRM1_9BURK/5-75 AC A0A0Q4XRM1.1
#=GS A0A6J5DNY4_9BURK/4-76 AC A0A6J5DNY4.1
#=GS A0A172UG16_9GAMM/11-82 AC A0A172UG16.1
#=GS A0A6B3SGY4_9BURK/4-75 AC A0A6B3SGY4.1
#=GS A0A7Z2GSN5_9BURK/4-76 AC A0A7Z2GSN5.1
#=GS Q7WX35_CUPNH/4-76 AC Q7WX35.1
#=GS A0A6P1J327_9BURK/4-76 AC A0A6P1J327.1
#=GS W7WVK0_9BURK/6-77 AC W7WVK0.1
#=GS A0A0L0M4C1_9BURK/9-81 AC A0A0L0M4C1.1
#=GS A0A850QIL1_9BURK/6-77 AC A0A850QIL1.1
#=GS A0A7X1FXD8_9SPHN/11-83 AC A0A7X1FXD8.1
#=GS D9SEQ3_GALCS/4-75 AC D9SEQ3.1
#=GS A0A4S3KMS2_9GAMM/13-81 AC A0A4S3KMS2.1
#=GS A0A1G6ZR77_9GAMM/7-73 AC A0A1G6ZR77.1
#=GS F4GGG6_ALIDK/8-79 AC F4GGG6.1
#=GS A0A2P1PZI1_9GAMM/5-73 AC A0A2P1PZI1.1
#=GS Q11ZD2_POLSJ/1-71 AC Q11ZD2.1
#=GS F4G940_ALIDK/7-78 AC F4G940.1
#=GS A0A4R0X5P7_9BURK/4-76 AC A0A4R0X5P7.1
#=GS Q1L9T1_CUPMC/4-76 AC Q1L9T1.1
#=GS A0A7Y6NSS6_9BURK/5-74 AC A0A7Y6NSS6.1
#=GS A0A562ZSC3_9BURK/4-74 AC A0A562ZSC3.1
#=GS A0A179BQC7_ACIFR/3-72 AC A0A179BQC7.1
#=GS A0A2I1DIN5_9PROT/3-74 AC A0A2I1DIN5.1
#=GS A0A246J8N1_9BURK/6-77 AC A0A246J8N1.1
#=GS A0A1I7M4E7_9BURK/246-317 AC A0A1I7M4E7.1
#=GS A0A7X6DU87_9BACT/4-73 AC A0A7X6DU87.1
#=GS Q21Q53_ALBFT/9-78 AC Q21Q53.1
#=GS A0A069PJ89_9BURK/4-76 AC A0A069PJ89.1
#=GS A0A1G6W027_9BURK/4-76 AC A0A1G6W027.1
#=GS A0A6L6PZC4_9BURK/5-76 AC A0A6L6PZC4.1
#=GS A0A7G5B9C0_9CAUD/53-126 AC A0A7G5B9C0.1
#=GS A0A7X6IAB1_9BACT/4-74 AC A0A7X6IAB1.1
#=GS A0A6S6XW74_9PROT/4-75 AC A0A6S6XW74.1
A0A4V3BPJ2_9BURK/4-76 ........................VDMTLQRSFPTVMVPRNEA.AAEMETSGERLLIAENGVFLEIRRSWINLVRQVA.rFTVRTAVPYGRVVESTKL-s...........
A0A0Q6W4E1_9BURK/5-76 .......................r-DAALQAACPVIAAPRHGD.LPPM-VPGLRIVAAANGLFVQVRLPWLDCLQRCG.sVDLGLPLPYGTLAPWL---rls.........
C5T055_ACIDE/7-78 .......................r-DQALLAACPVIAAPRFGA.LPDMG-NGQRVIVARNGWFVQTRLDWLDCIVALG.hGQPLMHLPYGEVAEHLRF-s...........
Q8XYU8_RALSO/53-126 ........................LDAKLWDSAPTVAVPKFAE.FKQLEDVGHRFLATAEGLFVEVRRPWLHVIQPVAplNGQTVRPPYGTVKQKVDL-a...........
A0A562BRU2_9BURK/4-76 .......................a-DITLQQSFPAVMVPRFAA.LSPLERSGERLLIAENGVFLEIARPWLRVVRRLG.aFQHRTAIPYGKANDDTV--lh..........
N6Y9C8_9RHOO/4-75 .......................r-DAILQQVTPTVMVPLYGA.FEPLGKLGHRFLSAGNGEWLEVRRSWLYARTRNL..SPGAVAKPYGQVTGTIEW-l...........
A0A346B7E1_9BURK/53-126 ........................LDVALFDSAPTVAVPKHAQ.FAPLLDVGHRFLMTAEGVFVEVRRPWLHVIQQLAkhSETGPRPPYGVVTPKIEL-a...........
A0A3D8K211_9BURK/53-126 ........................LDEALFDSAPLLAVPKHAA.FEPLKEIGHRFLATAEGIFVEVRRPWLHVIQLLSklPENAPRPPYGLIMPKIEL-t...........
A0A518U8F0_9PROT/4-75 .......................r-DVALQHSAPVVTVPRYGG.FTPLAENGHRFLVTGDGLWLEARRPWMYLRVPLV..CQKSVPMPYGWVGRELSL-t...........
A0A328Z754_9BURK/4-75 .......................r-DQALLASCPVVAAPRFGA.LPDM-PNGQRIVVARNGWFVQTRLDWLDSITALG.mEPPAMRLPYGDIEEHLRF-s...........
Q120V3_POLSJ/3-73 ........................LDSIIQGMFPTVIMPREGT.IAPATKNGTRYVVAGDGLWREVVLPWVTVMHKIA..-NSDFMLPYGAAEEAVVIK............
A0A0H3KQT7_BURM1/1-51 .......................m-------------------.----TRSGERLLITSDGVYLEVLRPWVRVVRRIA.hYAVSTAVPYGQVEETTAF-s...........
A0A1D9HCL7_9BURK/4-76 .......................r-DMTLQASFPTIEMPRFEP.LPPLARPGERLVVGSNGLFLEISRPWIHLVRRIA.aFNVPTAIPYGAVVAATDF-r...........
A0A139BN16_9PROT/4-75 .......................r-DVALQSVMSTVMVPHFSE.LVELDTPGNRILMASNGIWLEVCRAWFYARVPIA..KPLSMATPYGMVSEVLRF-g...........
W0SFK5_9PROT/4-75 .......................r-DIALQHSAPVVTVPRYGG.FTPLVENGHRFLVTGDGLWLEARRPWLYLRVPLV..CQKSVPMPYGWVGRELSL-s...........
A1VVA1_POLNA/3-75 ........................LDQITMGVFPLLAASQTGV.LQDPEKHGVRYVAASDGMWRAIDTAWLKALTPVA.lSSKKAVIPYGRLTQSVEF-l...........
A0A069NS28_9BURK/4-76 ........................ADAALQRSFPTVMVPRREP.VAPMQAAGERLLIGENGVFLEIDLPWLSVVRRIA.hYTVPTAIPYGNVAESTELR............
A0R7L0_PELPD/5-76 ........................MDAILQEQFPTVMVPRYGD.FVPLAHNGRRFLSASDGLWLEEKNQWLHILWPLA..LQNQVAMPYGSLQKKVDF-l...........
A0A1D9HD39_9BURK/4-76 ........................MDATLQASMPTVMVPRFGA.LVPMPSAGERLLMAANGVFLEVCRPWVRLVRRIA.sFSVPTAIPYGVVEEATDL-l...........
A0A7Y8GY46_9BURK/6-77 ......................le--RVVLENFPVTTMPQTGH.LVRPKSLGQRYVVAREGLFREVSTPWLYALLPLA..SIRGMQAPYGPCLPTVEL-t...........
A0A1E3LXB5_9SPHN/13-83 .llaavpcfpappsgsspgldavr-------------------.---ASRAGHCLAIGRDGVFLIVRRPWLELDVPVT..PPIAAYLPYGSVGE-----pra.........
A4JUM8_BURVG/4-76 ........................LDTVLQQSFPAVMVPSRET.VVPMTRSGERLLIASDGVYLEVLRPWVRVVRRIA.qYAVSIAVPYGKVEETTAL-l...........
A0A6S6Y1E3_9PROT/4-75 .......................r-DIALQQSAPVVAVPRYGG.FTPLSDNGHRFLVTGDGLWLEARRPWLYLRVPLA..SQKSVPMPYGWVGRELSL-t...........
A0A1E4QXH3_9BURK/4-76 ........................ADVTLQQSFPSVMVPRFSR.LEPMPRAGERLLIAANGVFLEIARPWLRVVRRLG.pFQHRTAIPYGDASEETDL-t...........
A0A1D8KCM5_9GAMM/10-86 .......................r-DHAALGITPMLMAPRFGE.LPPVGLGLYRYVAAQDGVYQEARSNALDVCLRVQ..---KGRFPYGSRRAR----ftmpfgpvpqkl
A0A7H0GK40_9BURK/7-78 .......................r-DQALLAACPVITAPRFGA.LPDMG-NGQRIIVARNGWFVQTRLDWLDSIVALG.hGSPSMRLPYGEVAEHLRF-s...........
A0A2N8K9T7_9BURK/4-74 .......................r-DVALQTSCPVVAAPRFGE.LPEMA-NGQRLIVAANGLFVQVRLDWLDCVQRLT..PAIGLPLPYGLLDERLRF-a...........
A0A0F7JUM1_9SPHN/13-84 .ilaaapcypvppigrspaidavr-------------------.---ASRTGHCLAVGRDGVMLIVRRPWLELDIPVT..PAFPAYLPYGSVGE-----rrae........
Q5NXB5_AROAE/4-75 .......................r-DMALQALTPTVMVPRFGC.FEPLSQPGHRFLVGQNGEWLEVRRAWMYARVQLT..QPSPVVKPYGVVTACLEW-l...........
A0A1Q8IKJ1_9BURK/4-76 ........................LDMTLQRSFPTVMVPRNEA.VAEMQTAGERLLVAENGVFLELRRPWLSLVRQIA.eFTVPTAIPYGRVTPATRL-l...........
A0A0Q4XRM1_9BURK/5-75 .......................r-DLALQASCPVLAAPRFGP.LPDMV-NGQRVIVAANGVFVQVRLDWLDCVQRLA..PPLGVPLPFGALQERLQF-s...........
A0A6J5DNY4_9BURK/4-76 .......................r-DTFLQTTFPTLPVPRFGA.FEELASNGHRFLVGSDAVVLEVRRPWLY-MRKIAmrNESGLALPYGQVSEVFEL-s...........
A0A172UG16_9GAMM/11-82 .......................r-DRILFGETPTYMQPLFGEkLPAPELGKHRFVIGQEGVVLEAINEVFEVRLPVA..-QSIIKLPYGVLG------aqgvrl......
A0A6B3SGY4_9BURK/4-75 ........................IDTALQSVTPTVMVPRHEP.FVPLQANGHRFLAASDGLWLEARRPWLYLCWPLV..RQEKVAMPYGTLKQTLS--av..........
A0A7Z2GSN5_9BURK/4-76 ........................VDIALQGSFPSVMVPTREP.VAPMDAPGERLLIASNGVFLEISRPWVRLVRRLS.sFDWATPVPYGEAAERTDL-m...........
Q7WX35_CUPNH/4-76 ........................ADAALQQSFPSVMVPRFGA.LAPMERSGERLLIAANGVFLEIVRPWLSVVRHLG.aFQHRTAIPYGEAAETTDLR............
A0A6P1J327_9BURK/4-76 ........................MDKAILEAFPLVATPIAEP.LQARKDTGIRFLASRQALMREISLPWIRLVHPVA.qCTEGFRLPYGEVYQSA---svl.........
W7WVK0_9BURK/6-77 ........................MDGVLLDMFPVVAVPPSGQ.LAKPSRDGQRYLVGNSGLFREVSTPWLYAVYPIA..SISGLATPFGEVKTTVTI-g...........
A0A0L0M4C1_9BURK/9-81 .......................g-DAALQRSFPSVMVPRREP.VAPMLAAGERLLIGENGVFIEINLPWLSVVRRIA.hYTVPTAIPYGRVVESTVL-r...........
A0A850QIL1_9BURK/6-77 ........................IDAQLQGQFPTVMVPIYST.LDGLDRNGHRFLMAKNGLWMEVKRSYLHAVIPVI..NQIPCVVPYGQVEKSLSI-l...........
A0A7X1FXD8_9SPHN/11-83 avleavpcypvpptgsspaidalr-------------------.---AARAGHGLIVGDDGMMLILRRPWLALDYRVT..EGPECHTPYGEVG------pdalt.......
D9SEQ3_GALCS/4-75 .......................r-DVALQSVMPTVMVPRYAE.LEELDTPGNRILMAENGVWLEVCHAWLYARIPVS..LPLRIPVPYGVIYEELR--fg..........
A0A4S3KMS2_9GAMM/13-81 ....................leta----TAMGMPVALAPIDSA.FERLHENGLRLIVAADGLYIEARSSRLYALRRVA..---PCVTPFGSVAARL---llr.........
A0A1G6ZR77_9GAMM/7-73 .................ldatlfp---------PLVPAPRFGS.LSQLQPGQKRFLGACDGLYVEARSAAMRLRLKVA..---NAVLPFGPLAAQVEL-d...........
F4GGG6_ALIDK/8-79 .......................r-DQALLAACPVVAAPRFGA.LPDMA-NGQRIVVARNGWFVQTRLDWLDSITALG.lEPPAMRLPYGEVEERLRF-s...........
A0A2P1PZI1_9GAMM/5-73 .......................t-DAVLFAATPLIPVPRFGT.LAPLDRGAKRFLAGADGLYVQSSTEAMEVTMKLA..---PVKLPFGECCERIVL-p...........
Q11ZD2_POLSJ/1-71 ........................MDAIIQSQFPTVLAPRFEA.LSPLETTGDRFILTRHQVLMEVSRPWLHAIQAIS..APFARQTPYG-AGPRL---gik.........
F4G940_ALIDK/7-78 .......................r-DQALLAACPVIAAPRFGA.LPDMG-NGQRIIVARNGWFVQTRLDWLDSIVALG.hGSPSMRLPYGEVAEHL---cfs.........
A0A4R0X5P7_9BURK/4-76 ........................VDQVLQGSFPSVMVPTREP.VVPMSAPGERLLIASNGVFLEIDRPWIRLVRRLG.sFSWRTPVPYGEAADATEV-r...........
Q1L9T1_CUPMC/4-76 ........................ADMALQQSFPSVMVPRHGA.LPALEQVGERLLIAANGVFLEIVRPWLRVVRRLG.eFQHQTAIPYGDATEVTELR............
A0A7Y6NSS6_9BURK/5-74 .......................r-DAAVQATCPVRAVPRYGD.L-PMHASGQRMLLAGNGLFVQMKTPWLDCTTRVA..-EVGMRLPYGSLDETIAF-a...........
A0A562ZSC3_9BURK/4-74 ........................LDEAILKTFPLLAAPGEGN.PPEAQAYGTRFLAANDGVWREINLPWIRIRHQLA..-PSLLPMPYGSVGGALEL-r...........
A0A179BQC7_ACIFR/3-72 ......................in--AMTKALFPVVSVNTDGT.IDPMEKPGTRYLIARNGIWLETTRPWLRAVVPHL..TESFPVTPFGEIAAR----il..........
A0A2I1DIN5_9PROT/3-74 .......................k-DQFIQKLYPTLPVSVIAP.MERLNTPGSRYWIANDGLWVETYRPWLYLLQPVS..VANKGTTPFGVI-------papvlel.....
A0A246J8N1_9BURK/6-77 .......................r-DLALQATCPCVPVPRFGA.LPDLD-LGQRVLVARNGLFLDVRRSWLRCVTRLA.dLPPTPPLPYGVLRERIEF-a...........
A0A1I7M4E7_9BURK/246-317 .......................r-DAALHAALPIVAAPRHSE.LPPMA-TGLRLVVAANGVFTQVRLPWLDCLQRCG.gIDTGLPLPYGTFAPW----lrls........
A0A7X6DU87_9BACT/4-73 .......................k-DEILKKQLPTLMVPHHEP.LPPLLEGYSRLLMARDGLWIESKTAWGHFVRPLW..-RSKRVLPYGALTQV----etl.........
Q21Q53_ALBFT/9-78 ........................IDRFLATDCPVITMPHDSEvFEPLKTPGHRLIVAAGGLYKEIRRAWLHAIVHVA..---RAQTPFGELQTTLSM-p...........
A0A069PJ89_9BURK/4-76 .......................g-DMALQRSFPTVMMPRREP.VAPMLAAGERLLIGENGVFIEIDLPWLSVVRRIA.aYTVPTAIPYGKVVESTVL-r...........
A0A1G6W027_9BURK/4-76 ........................ADAALQQSFPSVMVPRFGA.LPPLERPGERLLIAANGVFLEIVRPWLRVVRRLG.aFQYRTAIPYGEVEEATEMR............
A0A6L6PZC4_9BURK/5-76 .......................r-DAALLAACPVVAMPRHGE.LPPMA-TGMRLVVAANGLFVQARLPWLECVAQCG.hIDATLPLPYGSLAPQLAL-s...........
A0A7G5B9C0_9CAUD/53-126 ........................LDAKLWDSAPTVAVPKFAE.FKQLEDVGHRFLATAEGLFVEVRRPWLHVIQPVAplNGQTVRPPYGTVKPKVDL-a...........
A0A7X6IAB1_9BACT/4-74 .......................k-DEILQTRLPTVMVPVFEP.LPVLKAGETRLLMAEDGLWIEAEGDFGHFRRPLW..-KSRRKLPYGQVEIASE--lr..........
A0A6S6XW74_9PROT/4-75 .......................r-DIALQHSAPVVTVPRYGE.FEPLIDNGHRFLVTGDGLWLEARRPWLYLRVPLV..RQKSVPMPYGCIGRELSL-a...........
#=GC seq_cons .........................DtsLptshPsVhsP+aus.lsshppsGpRhLlAssGlalElcpPWLcslptlu...t.ssslPYGplspphph.h...........
//