#=GF ID   DUF2067
#=GF AC   PF09840.13
#=GF DE   Uncharacterized protein conserved in archaea (DUF2067)
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   COGs (COG3286)
#=GF GA   24.90 24.90;
#=GF TC   25.20 77.20;
#=GF NC   24.80 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR019202;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain, found in various archaeal proteins, has no known
#=GF CC   function.
#=GF SQ   36
#=GS Q6M0K8_METMP/7-198       AC Q6M0K8.1
#=GS A0A2R4ZMH2_9CREN/6-192   AC A0A2R4ZMH2.1
#=GS I0A280_FERFK/13-201      AC I0A280.1
#=GS A0A2T9WYT1_9CREN/7-200   AC A0A2T9WYT1.1
#=GS D7DR79_METV3/8-197       AC D7DR79.1
#=GS A0A0V8RUH5_PYROC/11-197  AC A0A0V8RUH5.1
#=GS A8AA06_IGNH4/8-191       AC A8AA06.1
#=GS I3TDP1_THEC1/8-194       AC I3TDP1.1
#=GS A6UTG3_META3/7-198       AC A6UTG3.1
#=GS D5TZM0_THEAM/11-196      AC D5TZM0.1
#=GS L0AAH3_CALLD/10-195      AC L0AAH3.1
#=GS Q8TZ80_METKA/11-198      AC Q8TZ80.1
#=GS A0A0U3EDA1_9CREN/8-192   AC A0A0U3EDA1.1
#=GS E0SNR9_IGNAA/16-198      AC E0SNR9.1
#=GS B8D6L0_DESA1/11-194      AC B8D6L0.1
#=GS A0A0F7FI31_9CREN/8-193   AC A0A0F7FI31.1
#=GS G4RLB4_THETK/7-189       AC G4RLB4.1
#=GS Y388_METJA/7-191         AC Q57833.1
#=GS A0A7L9FGL4_9CREN/8-193   AC A0A7L9FGL4.1
#=GS Q9YEZ0_AERPE/14-201      AC Q9YEZ0.2
#=GS S5ZDK7_9CREN/8-193       AC S5ZDK7.1
#=GS F6BDC1_METIK/7-191       AC F6BDC1.1
#=GS A0A830GTC4_9CREN/10-187  AC A0A830GTC4.1
#=GS A8MB33_CALMQ/11-198      AC A8MB33.1
#=GS B1L7Q6_KORCO/4-167       AC B1L7Q6.1
#=GS F0LJJ9_THEBM/9-196       AC F0LJJ9.1
#=GS A3DM81_STAMF/12-199      AC A3DM81.1
#=GS Q5JE87_THEKO/9-196       AC Q5JE87.1
#=GS E1QTA2_VULDI/11-204      AC E1QTA2.1
#=GS A1RXJ8_THEPD/8-193       AC A1RXJ8.1
#=GS Q8U4N0_PYRFU/9-196       AC Q8U4N0.1
#=GS A2BNA2_HYPBU/12-198      AC A2BNA2.1
#=GS G0EET6_PYRF1/10-197      AC G0EET6.1
#=GS Q8ZW47_PYRAE/7-188       AC Q8ZW47.1
#=GS C6A1R4_THESM/9-196       AC C6A1R4.1
#=GS D9Q2R3_ACIS3/9-193       AC D9Q2R3.1
Q6M0K8_METMP/7-198                  ...ikg----TEEEIIEICERISKlGIDYSFD.AKANYAENraynSARIKIFGDEKYKlvedhKNILTIIDTVHNK.....-YNADTKGLF.E.YKLNDLK----..YPVNKDLVLDTLSA.LKINFKYLKdENVIKCERKIEEINRILKDILDIYS.ELNFYNIgSKPVKNVLTLAVYITGRD..IDELIEEGLEKEL....FR-.EEDEK..IVLNKDINLTRK........
A0A2R4ZMH2_9CREN/6-192              .....y-TISCGNKCSEILEKISE.EIPGIYS.ATID----....GGVIKVVFDDNYIg...aREAIELIKEIVRSt...rLSSAGSRGLTaK.LSIRHLQRIIG..GPVHIEPLLDLLRL.RGYRASST-.GGYIETNAGLEEVVDMAMAISRCAN.ETPKELL.TPRARRIVITLCADSDAS..AEHVIGFLESRGV....FTK.NPDGR..LDISRSIDEI--rn......
I0A280_FERFK/13-201                 .....l-RIPKNADVERFLDAIMGsTI--ATQ.VMYRIKGN....SVEIRIIGDPVSV.....ENSIHRIRSAVEDfaikmGYPKEGRGIT.V.FG-SMLAKSLE..VPVPLEGFKRLLEL.ENIDFSYDEkEDLLVIYDDLEELKSLAKDLFDSYK.SAREIAR.-GIGAEIIAVLSVYSGLS..PMEIASIGEEEGV....FE-.KIEDM..YMLKADKDKALN........
A0A2T9WYT1_9CREN/7-200              ......FTFNNTNEALTFMEIVTS.RIKSKELlIKYDVSGG...iRVHVSIQGEPHEV.....ELYAVEIRRIYND....vRMMRGRYGVR.T.YDISLILNKARlkAAMPIDIVIDAMHI.MGINAEIEGsKIRIRDSLGLDDVVRMIEKMSELYR.DMLDMDI.SAQAKRVIAIYSFVTGKP..IKDCIIDLLNHEL....ITKyGDSEL..LVLSMDYDHAL-l.......
D7DR79_METV3/8-197                  ....sg----SEEETVEICEKVAKlSLECSFD.SKVKSTDGs.isSIMIKLYGNDRNKlkedhKDILAIITDVKNK.....-YNANKKGMF.T.YKLNDLK----..TPVNKDLIIDALKY.SKIKHEYIKeDNELLAKITAQELDDLLKDLQEIYV.DLSYYPIgSKPVKNAIVIGVYISGLE..MDEILELGLEEGC....FR-.EEDDR..IVLNMDITKVK-n.......
A0A0V8RUH5_PYROC/11-197             .vnapp-----GVPIEKLYEKIGS.AL-RSNY.AEVSIRDG....KVYVELVGTDYEI.....KDTWYRVRQALAEl...wEIYKLE-TRR.E.ASIEAIVKEAG..RTFPPEALVHALLL.RGYDARLSEdKSILYTDAPPEEVIELARRIAEVIE.GLRFRVK.GAAAKRMIAALAAGLGED..PERVIEYGLRSRV....LE-.ETEEG..LVLREEWRRGL-r.......
A8AA06_IGNH4/8-191                  ...ikc---INEEVCYELLHKISE.EV-SARW.IKGEVDGN....KLLIEALGFPYEL.....KELRYEIEELKKE.....-IESAMLPYT.R.VSVDELPKLTK..AAVPIDALVEALKL.LGYSAKVE-.GRTLVSDAPFEEVAALARKMKEIID.SEIVRFRlPHSMKKAVAVLSTVYGVN..PEEVVNVMLREGL....LE-.EGDFK..YEQREEWRKVIK........
I3TDP1_THEC1/8-194                  frvrcv-----SEPCEKLAEMISE.HIALVGE.YAITIHDN....WISIEFHGYESEI.....KRAWARIKSLLAG.....-LPKAGRGGF.S.LELNAMFRELG..STFPPRVLVEVLKR.RGFTAALDKdSNRVITNAGKEVVYELSKRIIELAK.RIPGNVR.GLSTKYYLLTIGALTGIP..LEEVLERALALSH....LRK.DEEGS..IVLDIEWVQ---gv......
A6UTG3_META3/7-198                  ...ika----TNDEIEEICDAISKmDIDCSIE.SKVSYSKDeiinILRIKVYGHDKIQmmqdyKNIMNLADRIHKK.....-YKPNKIGLF.E.YQLNDVK----..YPVNKELLKEAIGA.LDIEYKYDEeKNIIKCSLPLEELHDMTKELYGIYK.ELDFTNVgPKPVKNIITVISYITKKD..IYDIIDESIEQEF....LR-.EENDK..IVLNKDIKLIK-e.......
D5TZM0_THEAM/11-196                 ...ncr-----HNECIEIIQRVSE.KLPSIDT.VEYEVREG....GMLIEMYGYSTDI.....KKAWTVIKEYIKH.....PGRQGGKGMF.K.YSLKTLSKQAG..KTFPPAVLVKLLNL.KGFKAQYSSiDEAIHTDAGLEVLMDLINRVDAAVA.LVRDKVK.GTAGKYYLTTLMIATGLG..LEDVVNESLRLGH....LRVnEEDGL..LTLAVEWDK---gv......
L0AAH3_CALLD/10-195                 ......FNLKEGYDIENIFKKINT.-VISSQE.ATIKVENN....KLIIDFYVTPRDI.....NYIKSKIKEILSF.....ETNKNKVKGF.K.YSLKDLNPEGG..-KDFFDMLEFCLSK.LGYKTTIQ-.EEFLITTARKEKVYSLANIINENLK.HISGKNY.GNALIKALACYLTLRERD..FEK-INNVIEKGLslgiLE-.ENKNK..IYTRYSWKDTY-e.......
Q8TZ80_METKA/11-198                 ......FTFPDRDSAQRFLRAVEAtQARGVDT.V-VELRGT....RVKVKVFGPHAAV.....KAHIRKLGELRRT....vLSESEEEKQV.R.LHLSTICREAG.aPKIPSELLRDALRR.RGYRVRVR-.GPWITTNAPMSELREFVRELAEAYR.EARFYAA.SEPVRRMLAILSHEYDVD..PMDLAYEAIERGV....LRE.GEDGR..CELREDPKSTE-r.......
A0A0U3EDA1_9CREN/8-192              .....v-KCRSNESCLELLNKITE.NV-SSRF.LKSEIKGN....TLQLEVIGLPYEL.....KEIKYDIEMLKKE.....IESKHIKGNK.Y.IKLHELGKLFH..GTISIEVLSTVLKS.RGYYVEVD-.DDKLYTNAPMDIIEEIVKKSKEIQEdEVVKYKL.SSAAKRVVITLSLITDTP..PNEVIELLKSQGF....LE-.QGSFR..YQLKENANAV--in......
E0SNR9_IGNAA/16-198                 ...scp----NVDFCLNILEKIDE.ELSLESD.IHVEFKNN....KLIFRVIGLEPNV.....ISSINKIRNYISS....lQLVRSLNPGR.G.ISSDDIAKLIR..KTIPLDVLGEVIKRdLGAHVKID-.KGVIYVDIDLDTLLSYAERVSRAMD.KVSGLSF.SYSLKKLFIATIALYDSN..PMEVLKILQDNNL....LN-.---EN..LELVVPWTKA--ld......
B8D6L0_DESA1/11-194                 ...pcr-----GEECLKLYELVKE.RVPSIEH.VEFAVTSN....GLIVDAYGYETDL.....KKLWIELKNYSRM.....AKGVSGPGLQ.A.FSIDVIVKLTR..KTFPPEVLVKILEK.QGYKARLE-.DGTIYTNIEKNRILELVERISELNT.AIRGRVK.GTAARYFIITVTIITGLQ..LDDAINHAVEAGL....LGV.DESGL..YVLKHEWRDA--vd......
A0A0F7FI31_9CREN/8-193              ....lv--FSSPEEALEFLEMLER.ILPGKSF.L-GELKTN....KVKV-FVPESENS.....EQVIRKIRELYNQ.....KRRPYAYGLV.KdYDISTVFSLSRleQPIPLSLLITTLRI.QGYKAEAV-.RDKLRTNAPLDQLTKMVEKLSKLYG.ELLEIKA.TAQARRLIALYSLTKNLP..TEEAIRQLSEQGF....LT-.EDRGR..ISLKLNYETALR........
G4RLB4_THETK/7-189                  ......VKFASKEELEHFLELLPV.YVKTEYY.A--IVRGN....NVYIQLSGSPADI.....KRSAAVVKTAAGI.....-ARTKIRPLR.S.YPLDMVFAKAEvvAPVPPDVLADYLEA.SGHRAKLR-.GLDLQTDATFEEVTRALERLSAVYK.TLEKYPV.SPHAKRVVALYIAVKRVS..PEEALERLTSIGI....L--.NKGDV..YSIRGNLAAAKK........
Y388_METJA/7-191                    .....s-KVSCDEELLELCERLSRmDIDCTIE.S----KGN....RVRVYVFGYDKDSlkxnyRTIREVMEKVKRK.....-YQKDDEGLY.K.YPLFELK----..YPVNKNLIIDALKT.LGYKVIYLEdENAIKTNVDINKFNEILGELHELSQ.ELRFSNLgSKPVKNLVVLVSYITKKP..VDDVIEEALEKGF....FR-.EEEGR..IVLNKDINLAKK........
A0A7L9FGL4_9CREN/8-193              ....lv--FSSPEEAVHFLKTLEK.LLPGKSF.L-GELKAN....KVKIFI-PESENS.....EKTMHKIKQLYNQ....qRQPYSYGVMK.N.YDISSIFSMAKleVPVPVTLLVEALKI.QGRKAIIK-.GDILYTDATLNEIIKVVERLSVIYK.EVLSLET.TAQARRLISLYSFVNNKP..VDSAVEELSKLGI....LT-.ESSGK..LTLKVNYDVALK........
Q9YEZ0_AERPE/14-201                 .....l-RLLDVDDFERFLERLSR.AV-KVDY.SSWRREGD....KLLIEMVGGESSI.....RESIVRVKALLRE....yRRRARGGGLF.S.YSLRRVSREAG..VAVPPDVLSTVLSG.MGYRVEARSgEGVLDTDAPWSLVVEVAREVGERLR.EAAAQPL.TTSSRKLVVAASILAGST..LDDAVRAAVEEGL....LEE.DEKGR..LLVRGGWRESLK........
S5ZDK7_9CREN/8-193                  .....l-NFDTPEEAISFLKLITS.RIKYSGL.Y-GEIKGK....KLKLF-IPESQRT.....EEVVNEVKTLYRE....lHGAKNAFQKK.R.FKIQTVLSLAKleTAIPVPVLVDIIKL.QGKHARLA-.GETIETSLELNELVKLAEQVSSAYH.SAIHMPL.TSSARRLLVVASLTLGKN..PEETVSLLLSRNL....LR-.EEDGT..LSLSMDYERSL-e.......
F6BDC1_METIK/7-191                  ...akt---SCSEEMLEICDRISKlNIDCLIE.S----REN....LLRIKIFGYDKDSivenyRTIVSIIERVHRK.....-YTKDEEGMY.E.YSLSDLK----..YPVNKDLIIDTLKA.LGHNVKYLKeEGVIKTSLELDKLNEILCELNEIYG.ELAFRNIgSKPVKNVIVLAAYLTGKD..VDEVIEEGLEKEF....FR-.EENGR..IVLNKDIKLAKK........
A0A830GTC4_9CREN/10-187             ......LKFKSSEDAITYVDLLTR.RI-KVGE.LIIDVKSN....VVELRVRGGREAG.....DIMMAEALKIYGA.....-LKARN--GG.S.LDLSVLITMAQppHPVPFDVVTTALNL.RGFPSELS-.GMKLRTKAPLDLVISIIKSTSSLYA.EMARMNI.TQNAKKIIATHALLRGLD..VPGAIQELMEKGA....VRE.NES--..------------sgsalita
A8MB33_CALMQ/11-198                 ......FKVRSTDEAVRFINTYLS.EV-KAKE.VYVKYRGS....RLEVKVRGNPVLA.....KVLSTEAHKVYGT.....--LRQGRLIN.V.FDLTVIIREAKpkSPIPPETIELTLRL.MGYYAELN-.ESRLRTGASLSKVIETVRRLSEAYA.AMVDLDI.SSSAKRIIASLAVAKGVS..IYDAIDELVNMDV....LNKgKVNGReyITLKANL-----ndivn...
B1L7Q6_KORCO/4-167                  ...rdy------------------.-------.-SYKYSVD...sGLKITLFGDKEEL.....RDSEAIVRRSYRNf..riV-RNPVGGLY.R.YPSDWLS-EHG..-GISMSLLTLSLRA.AGLTAIWK-.EDILHTALEPEEIIDLMLELKSLSE.EIRYEVR.QRKAREVIVAVSVNSGVS..PFDVLELAEEEGF....MEK.DDEGL..WRFKADPE----lvmr....
F0LJJ9_THEBM/9-196                  ......IHVRDDVEKEEFMRELQKlNLPAFIY.VHGKLN--....SLKINIQGTKDEI.....RDAIYKIKDIHKRv..rsRLYANKRGLY.R.YVLDDIFREAG..VSISAPILLKTLEL.LGETVEFK-.DNELETSMPWNEIVNLTRKLGEYLA.DISLQT-.TRQIREVALPLAIVFDID..PEEVLDLMVEVGV....AEYkEDKFK..YELVKNKEQAM-e.......
A3DM81_STAMF/12-199                 ....ck-----GDECFKLAELIRE.KAPQVEL.VEIDITDT....GLYIEMYGYRTDI.....KNAWEYIRRLVSSa..kaSEQYGKQGTR.R.IKIEYLVEKKK..KTFSPVVLSEILKH.KGFKADLSDyKDEIVTDAPLEVIEEIIDNMWDILE.KIKYDVR.GTTTKYFVTIASILTNKD..PQEVIMKAYSIGL....LFK.DEDEK..YRLRKEWRKAI-s.......
Q5JE87_THEKO/9-196                  ......IHVRDDREKEEFMRELQRlRLPAFIY.VHGKLD--....SLKINVQGTKDEI.....REAIQKIREIHTRv..raKLYPDRMGLY.R.YKVDDLLREAG..TSVSTPIIVKTLEL.LGERVELK-.DDEIVTSMPWEEAVEVTSRLGEALA.EIALQT-.TRQIREVVLPVAIAYDLD..PEEVLERLVELGL....AEWkEDKFK..YELVKNKEQALE........
E1QTA2_VULDI/11-204                 ......FTFNNVNEALTFMEMLTS.KIKSKEL.LIRYDTGSg..vRVWVSIQGEPHEV.....ELYSMEIKRVYND....iKLMRGKFGTR.A.YDVSLILSKARlsAAIPIDLIIDLLQI.KGINAELDGsKIRVVGDVKLEDLIKLAEDISRIYN.ELIDAEV.SAQAKRIIALYALLMSKG..VKDSIKELLDKGL....LSKyGDSEL..LVLSMDYKHAL-s.......
A1RXJ8_THEPD/8-193                  ......FTFNDSGEAVSFLSMLKK.ELGDARL.Y-GEIKGK....KLKVFI-PEGERT.....DDIVRRVKTLYRE....iHEKTLTVRPR.K.LGVSTILSMANleVAIPVPALADVLNM.VGKKAVLR-.GEYLETNASLKEAVEFAEKLSRAYK.SLLHEPL.TATARRLAAVASVVLGTE..PDKAVDLLVSKGI....LK-.QVEGN..VSLSEEYTKSL-s.......
Q8U4N0_PYRFU/9-196                  .....l-HVRDDIEKEEFMKEVQRlNLSAFIY.IHGKLD--....SLKVNVQGTKEEI.....REAIRAIRDAHKRv..rgRLYPDRKGLY.T.YYPEDIFREAN..ANISLPILIKTLEL.LGERVEVK-.EDYIKSSMPWREIVELVRRLNEVLS.QIALQT-.TRQIREVVAPVSVAYKID..PEELLDLLVDLGI....AEYkEDKFK..YELVKNKEQALK........
A2BNA2_HYPBU/12-198                 ......INLPPGIPLEKIYEKVSS.AF-KAGY.AEISIQGN....KLFLEVVGTEYEI.....KDTWYRVRQAVSEl...wELYRLSK-GM.E.ASIEALVREVG..RTFPPESLVYALRL.RGYKAELSDdKSRITTNAPLDVVVEVARTIAEVID.ELRFRVK.GTAAKRMIAALAAG----..LQEPAEKVIEYGLrsrvLE-.ETEEG..IELREEWRRGL-r.......
G0EET6_PYRF1/10-197                 ......IRVPPGIDLDKLNERLRE.AI-RVPY.AEIEVEKD...gRLRIMLVGVEADV.....KDSWYRIKNVVAElwdlyNLSKKG----.E.VSVDAIVKEIR..RTFPPQALVEALSL.RGYRAELLE.GNVIRTNAPLDVVLSLASRIAEVLE.EIKFDVR.GTAAKRVVAAVAAAFDVV..PQEVIEVGLKADV....FEH.DEEGK..IVLKREWRQAIR........
Q8ZW47_PYRAE/7-188                  ......FKFNSREEMERFLEFLEK.HVKTTYL.VTTRLT--....HVYVQLEGEGKEL.....EDAASLVKKLAGL.....--ARQQRHTV.Q.IPLVVLFRDADlaRPVPPDVIADALKL.KGMPSEVR-.GGVLETAASYEEVLKTAEALSKIYE.ETERLPL.TPQAKKIVVAYAFARGMP..VDKAAEELAATGL....L--.NVGSV..ISLRNTLEETR-r.......
C6A1R4_THESM/9-196                  ......IHVKDDLEKEELMKELQKiELPAFIY.VHGKLN--....SLKINIQGTKDEI.....REAMEKVREIHYRv..rsRLYPDRKGFY.Q.YNVNDIFREAG..VSISIPTLTKTLEL.LGEHADLK-.GDKLISSLSWGEIVNLVKKLGEVLT.DISLQT-.TRQIREVIAPISVTLNID..PQEVLELAVDFGV....AEYkEDKFK..YELVKNKEQAM-e.......
D9Q2R3_ACIS3/9-193                  .iklpr----NTADIEALLEKISE.KA-SASI.ISTEIRNN....RLVIEIQGSVRAS.....KDIKRTVHDILRD.....---QTSRSFR.S.VITEDRIRDMG..YKGPMDVLSFTLKK.MGFDTEWE-.PPVLRSNAQVSVIRQVAQKLSDALK.LVSGLNL.SESARKAVMAVLALSGAStdVERVISVGLSKGV....LAR.DRNNK..ILSVTEWREA--ad......
#=GC seq_cons                       ........h.ssp-t.chh-tlpc.pl.shth.sphclcss....plhlplhGpppcl.....+chhtcl+clhpc......htpsttuhh.p.aslsslhp.st..tslPh-lLhcsLch.hGhcsclp..cshlpTsssh-clhclscclu-lhp.clthhsh.opss+cllsshuhhpshs..s--llchhlcpGl....Lc..--csp..l.Lptshcpuh.........
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