#=GF ID DUF2116
#=GF AC PF09889.13
#=GF DE Uncharacterized protein containing a Zn-ribbon (DUF2116)
#=GF AU COGs;
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF AU Eberhardt R;0000-0001-6152-1369
#=GF SE COGs (COG4068)
#=GF GA 21.80 21.80;
#=GF TC 21.80 21.80;
#=GF NC 21.70 21.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF CL CL0167
#=GF RN [1]
#=GF RM 21348639
#=GF RT Ab Initio Modeling Led Annotation Suggests Nucleic Acid Binding
#=GF RT Function for Many DUFs.
#=GF RA Rigden DJ;
#=GF RL OMICS 2011;0:0-0.
#=GF DR INTERPRO; IPR019216;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This domain, found in various hypothetical archaeal proteins,
#=GF CC has no known function. Structural modelling suggests this
#=GF CC domain may bind nucleic acids [1].
#=GF SQ 160
#=GS A0A1A7KGH2_9FLAO/1-42 AC A0A1A7KGH2.1
#=GS A0A1T5LSE4_9BACT/6-46 AC A0A1T5LSE4.1
#=GS A0A286IDE2_9HYPH/2-37 AC A0A286IDE2.1
#=GS A0A179DLB2_9SPHI/2-56 AC A0A179DLB2.1
#=GS A0A3S0C4X7_9FLAO/2-46 AC A0A3S0C4X7.1
#=GS A0A0P7C226_9BACT/2-41 AC A0A0P7C226.1
#=GS A0A4P2VAQ2_9ARCH/12-70 AC A0A4P2VAQ2.1
#=GS A0A363D1B3_9PROT/2-31 AC A0A363D1B3.1
#=GS A0A2U1S8P4_9EURY/4-62 AC A0A2U1S8P4.1
#=GS A0A0Q4B2P4_9ARCH/5-64 AC A0A0Q4B2P4.1
#=GS F0T643_METLA/3-61 AC F0T643.1
#=GS A0A6I6G4I6_9BACT/4-49 AC A0A6I6G4I6.1
#=GS A0A4R3KM12_9SPHI/5-55 AC A0A4R3KM12.1
#=GS N6VPI4_9ARCH/6-64 AC N6VPI4.1
#=GS A0A0D4CKB1_LIMMU/1-54 AC A0A0D4CKB1.1
#=GS A0A315XQQ1_9EURY/4-62 AC A0A315XQQ1.1
#=GS A0A076GXJ0_9SYNE/59-99 AC A0A076GXJ0.1
#=GS A0A081NT18_9BACL/12-76 AC A0A081NT18.1
#=GS A0A1Y4F259_9FIRM/74-116 AC A0A1Y4F259.1
#=GS D7DR63_METV3/2-60 AC D7DR63.1
#=GS U6EBV4_9EURY/3-61 AC U6EBV4.1
#=GS A0A345J5B7_9PROT/1-30 AC A0A345J5B7.1
#=GS A0A3D9H8A4_9FLAO/1-42 AC A0A3D9H8A4.1
#=GS A0A8J7X8D6_9EURY/4-62 AC A0A8J7X8D6.1
#=GS A0A1W2CTK2_9SPHI/3-50 AC A0A1W2CTK2.1
#=GS A0A1I1AXQ3_9BACT/4-44 AC A0A1I1AXQ3.1
#=GS A0A4S8RIK4_9FLAO/1-38 AC A0A4S8RIK4.1
#=GS A0A2P2BR39_9FIRM/2-56 AC A0A2P2BR39.1
#=GS F4C0R0_METSG/1-43 AC F4C0R0.1
#=GS A0A0Q4B680_9ARCH/6-63 AC A0A0Q4B680.1
#=GS A0A166F812_9EURY/3-61 AC A0A166F812.1
#=GS A0A6M1THY0_9BACT/4-51 AC A0A6M1THY0.1
#=GS A0A257KB83_9FLAO/19-63 AC A0A257KB83.1
#=GS M4YMN8_THEXX/6-64 AC M4YMN8.1
#=GS A0A1T4LYJ4_9BACT/4-45 AC A0A1T4LYJ4.1
#=GS A0A1E5UF19_9FLAO/2-43 AC A0A1E5UF19.1
#=GS A0A840RP33_9BURK/32-68 AC A0A840RP33.1
#=GS A0A1B7Z903_9FLAO/2-46 AC A0A1B7Z903.1
#=GS A0A286IL71_9BACT/2-36 AC A0A286IL71.1
#=GS Q2NEL5_METST/4-62 AC Q2NEL5.1
#=GS B5IGX9_ACIB4/29-86 AC B5IGX9.1
#=GS A0A345IXI9_9PROT/1-30 AC A0A345IXI9.1
#=GS A0A1Y2RIH0_9BACT/5-56 AC A0A1Y2RIH0.1
#=GS A0A0Q4B9L0_9ARCH/6-65 AC A0A0Q4B9L0.1
#=GS G7WQZ4_METH6/5-62 AC G7WQZ4.1
#=GS A0A2U1AJM7_9BACT/8-53 AC A0A2U1AJM7.1
#=GS F6BAL6_METIK/3-61 AC F6BAL6.1
#=GS A0A8J8KBP9_9FLAO/1-46 AC A0A8J8KBP9.1
#=GS A0A2Z4L9T9_9EURY/4-62 AC A0A2Z4L9T9.1
#=GS A0A318THI7_9BRAD/14-17 AC A0A318THI7.1
#=GS A0A810PQH1_9FIRM/2-60 AC A0A810PQH1.1
#=GS Q8TXB3_METKA/6-63 AC Q8TXB3.1
#=GS A0A5N5IXM0_9FLAO/1-48 AC A0A5N5IXM0.1
#=GS A0A840BEF0_9RHOO/31-66 AC A0A840BEF0.1
#=GS A0A430JC71_9BACL/1-57 AC A0A430JC71.1
#=GS A0A142EQN5_9BACT/2-43 AC A0A142EQN5.1
#=GS A0A6S6XJ47_9FIRM/74-116 AC A0A6S6XJ47.1
#=GS D2RE40_ARCPA/5-62 AC D2RE40.1
#=GS A0A6B9T7T6_9ARCH/8-67 AC A0A6B9T7T6.1
#=GS A0A1G7AP64_9FLAO/2-45 AC A0A1G7AP64.1
#=GS A0A5B8VJ16_9BACT/6-53 AC A0A5B8VJ16.1
#=GS A0A2T4DCZ6_9BACT/2-44 AC A0A2T4DCZ6.1
#=GS B2ZY68_9CAUD/31-69 AC B2ZY68.1
#=GS A0A086BLF2_9FLAO/1-42 AC A0A086BLF2.1
#=GS A0A5B9D6K7_9ARCH/19-77 AC A0A5B9D6K7.1
#=GS O26966_METTH/8-66 AC O26966.1
#=GS A0A166CYZ5_9EURY/3-61 AC A0A166CYZ5.1
#=GS N0BH86_9EURY/5-62 AC N0BH86.1
#=GS A0A519LNQ7_9FLAO/1-42 AC A0A519LNQ7.1
#=GS R9T456_METII/7-65 AC R9T456.1
#=GS A0A7L8V9B7_9PROT/1-29 AC A0A7L8V9B7.1
#=GS A0A1V6N102_METAZ/3-61 AC A0A1V6N102.1
#=GS A0A328PIF7_9EURY/3-61 AC A0A328PIF7.1
#=GS A0A4Q0Y1N2_9PROT/1-30 AC A0A4Q0Y1N2.1
#=GS A0A1D2W9R9_9EURY/3-61 AC A0A1D2W9R9.1
#=GS A0A120MI45_THEX5/18-76 AC A0A120MI45.1
#=GS A0A0B8YG97_9SPHI/2-49 AC A0A0B8YG97.1
#=GS A0A133VAL9_9EURY/6-64 AC A0A133VAL9.1
#=GS A0A411E6A3_9FLAO/2-42 AC A0A411E6A3.1
#=GS B1YMK0_EXIS2/2-58 AC B1YMK0.1
#=GS A0A4Q0XT42_9PROT/1-30 AC A0A4Q0XT42.1
#=GS M4YUF6_THEXX/10-71 AC M4YUF6.1
#=GS A0A7H8PK27_9FLAO/1-41 AC A0A7H8PK27.1
#=GS A0A410URN9_9BURK/26-69 AC A0A410URN9.1
#=GS A0A1G9LSZ8_9BACT/4-53 AC A0A1G9LSZ8.1
#=GS A0A2A2G981_9BACT/3-51 AC A0A2A2G981.1
#=GS A0A3S9PBA2_9BACT/1-54 AC A0A3S9PBA2.1
#=GS A0A0Q6DJ96_9HYPH/5-48 AC A0A0Q6DJ96.1
#=GS A0A143XVI7_9FIRM/2-59 AC A0A143XVI7.1
#=GS A0A328SAG5_9EURY/4-62 AC A0A328SAG5.1
#=GS A0A0W7TIY3_9ARCH/6-63 AC A0A0W7TIY3.1
#=GS M9SJD7_METAX/5-63 AC M9SJD7.1
#=GS A0A554VHN1_9FLAO/2-44 AC A0A554VHN1.1
#=GS A0A5N5GY82_9ROSA/31-86 AC A0A5N5GY82.1
#=GS A0A177L0R8_9BACI/2-62 AC A0A177L0R8.1
#=GS A0A4S4AP69_9RHOO/32-68 AC A0A4S4AP69.1
#=GS A0A7G5BAG3_9CAUD/34-73 AC A0A7G5BAG3.1
#=GS R9SKQ2_9EURY/4-62 AC R9SKQ2.1
#=GS A0A5B7UIG7_9FLAO/2-43 AC A0A5B7UIG7.1
#=GS A0A0A7LFV4_9ARCH/9-68 AC A0A0A7LFV4.1
#=GS A0A0X8UX94_THEX5/17-75 AC A0A0X8UX94.1
#=GS A0A7I9VQC4_9DELT/5-29 AC A0A7I9VQC4.1
#=GS A0A1G9S5U4_9BACT/2-42 AC A0A1G9S5U4.1
#=GS R6V9A9_9CLOT/2-57 AC R6V9A9.1
#=GS M9SH94_METAX/11-69 AC M9SH94.1
#=GS R8W5A9_9CLOT/54-98 AC R8W5A9.1
#=GS A0A398BB72_9BACI/4-34 AC A0A398BB72.1
#=GS A0A4V1TQR9_9FLAO/4-41 AC A0A4V1TQR9.1
#=GS A0A317F8T8_9PROT/6-9 AC A0A317F8T8.1
#=GS A0A1M6JT98_9FLAO/2-43 AC A0A1M6JT98.1
#=GS A0A5B9D7N2_9ARCH/14-76 AC A0A5B9D7N2.1
#=GS A0A1C2GS16_9SPHI/7-55 AC A0A1C2GS16.1
#=GS A0A328S2I9_9EURY/4-62 AC A0A328S2I9.1
#=GS R9T6T4_METII/8-66 AC R9T6T4.1
#=GS A0A495RJ29_9GAMM/29-63 AC A0A495RJ29.1
#=GS A6UV06_META3/4-62 AC A6UV06.1
#=GS A0A4Y9QNV2_9BACT/2-42 AC A0A4Y9QNV2.1
#=GS A0A0Q4B010_9ARCH/8-65 AC A0A0Q4B010.1
#=GS E3GZH9_METFV/3-61 AC E3GZH9.1
#=GS A0A174FB75_9FIRM/2-58 AC A0A174FB75.1
#=GS A4AWJ0_MARSH/3-44 AC A4AWJ0.1
#=GS D3E210_METRM/3-61 AC D3E210.1
#=GS F3Z022_DESAF/6-59 AC F3Z022.1
#=GS A0A1Y4BJA4_9FIRM/74-116 AC A0A1Y4BJA4.1
#=GS A0A2H5V2F9_9ARCH/12-70 AC A0A2H5V2F9.1
#=GS D5V3C0_ARCNC/2-46 AC D5V3C0.1
#=GS A0A7M2RI34_9FIRM/2-57 AC A0A7M2RI34.1
#=GS A0B8E8_METTP/32-86 AC A0B8E8.1
#=GS A0A0W7TIS9_9ARCH/2-60 AC A0A0W7TIS9.1
#=GS A0A7S8MRP4_9CAUD/35-74 AC A0A7S8MRP4.1
#=GS A0A328SLD1_9EURY/4-62 AC A0A328SLD1.1
#=GS A0A1E5T1D4_9BACT/2-42 AC A0A1E5T1D4.1
#=GS D5UZU6_ARCNC/1-30 AC D5UZU6.1
#=GS A0A6B9TA06_9ARCH/9-67 AC A0A6B9TA06.1
#=GS A0A0M3J2R6_ANISI/11-62 AC A0A0M3J2R6.1
#=GS D3S1B2_FERPA/5-62 AC D3S1B2.1
#=GS A0A1P8KM38_9PROT/2-31 AC A0A1P8KM38.1
#=GS K1LUV0_9FLAO/2-43 AC K1LUV0.1
#=GS A0A024QHE0_9BACI/243-281 AC A0A024QHE0.1
#=GS A0A0F7DBE8_9EURY/5-62 AC A0A0F7DBE8.1
#=GS A0A0A7LEI6_9ARCH/6-64 AC A0A0A7LEI6.1
#=GS Q6M087_METMP/2-60 AC Q6M087.1
#=GS A0A366MF33_9EURY/3-61 AC A0A366MF33.1
#=GS K1LB73_9BACT/4-57 AC K1LB73.1
#=GS F2KT88_ARCVS/5-63 AC F2KT88.1
#=GS O29389_ARCFU/5-62 AC O29389.1
#=GS A0A0Q6AZ33_9FLAO/1-41 AC A0A0Q6AZ33.1
#=GS A0A3A5W905_9ARCH/27-87 AC A0A3A5W905.1
#=GS A0A7G5B853_9CAUD/35-74 AC A0A7G5B853.1
#=GS A0A1D3KZU0_9EURY/3-61 AC A0A1D3KZU0.1
#=GS A0A1M7ZCU1_9BACT/1-42 AC A0A1M7ZCU1.1
#=GS A0A6M8N930_9PROT/2-47 AC A0A6M8N930.1
#=GS A0A1M5VA85_9CLOT/3-58 AC A0A1M5VA85.1
#=GS A0A2R3Z428_9FLAO/1-42 AC A0A2R3Z428.1
#=GS A0A166CIP2_9EURY/3-61 AC A0A166CIP2.1
#=GS G4Q420_ACIIR/50-98 AC G4Q420.1
#=GS A0A1H6LWP7_9FLAO/3-45 AC A0A1H6LWP7.1
#=GS A0A495KIE9_9FLAO/1-43 AC A0A495KIE9.1
#=GS A0A2D0N9U2_FLAN2/1-54 AC A0A2D0N9U2.1
#=GS A0A399SKM3_9BACT/2-52 AC A0A399SKM3.1
A0A1A7KGH2_9FLAO/1-42 ..me-----.C.IECGEKIi.gR...S.....D..K....KF..C.N...DSCR..NA...Y.....N....NNQ......N.K.D.-.-...-...-..---.-.-.-.---.-----------ssnlmrnv............
A0A1T5LSE4_9BACT/6-46 ..kk----V.C.IECGTPI...Kg.rI.....D..K....KF..C.S...DQCR..SA...Y.....N....NK-......-.-.-.-.-...-...-..---.-.-.-.---.-----------lnsddtnymr..........
A0A286IDE2_9HYPH/2-37 .nqi-----.-.-------...-...-.....-..-....--..-.-...----..-D...L.....T....EKQ......K.K.A.R.R...S...R..NVA.L.G.I.VLA.VLAVMFYVV--ti..................
A0A179DLB2_9SPHI/2-56 ...d---KQ.C.LDCGNSI...Kg.rA.....D..K....KF..C.D...DHCR..SN...Y.....N....NRI......K.A.T.E.N...-...-..---.-.-.-.---.-----------pqvkkinqillknwkilt..
A0A3S0C4X7_9FLAO/2-46 .ess---RM.C.PVCGATI...Kg.rS.....D..K....KF..C.S...AKCR..SIn.qY.....E....NRQ......K.-.-.-.-...-...-..---.-.-.-.---.-----------seafyfkv............
A0A0P7C226_9BACT/2-41 ...e---RS.C.PECGRPIf.gR...A.....D..K....KF..C.S...EPCR..NS...Y.....N....NKL......K.A.V.S.-...-...-..---.-.-.-.---.-----------tnli................
A0A4P2VAQ2_9ARCH/12-70 ..pl--HTH.C.KVCGKPI...P...L.....G..Q....VY..C.S...KECA..EK...D.....R....RSQ......R.R.S.T.T...M...F..AVY.M.G.V.VAV.VFIVLMLL---tah.................
A0A363D1B3_9PROT/2-31 ...m---SH.C.PFCKKKI...A...M.....S..K....AF..C.S...RSCK..EN...Y.....F....---......-.-.-.-.-...-...-..---.-.-.-.---.-----------qli.................
A0A2U1S8P4_9EURY/4-62 ....EPHKH.C.PICGTPI...P...L.....N..E....LV..C.S...PDCQ..KI...W.....N....QRL......A.Q.Q.K.K...S...R..YGL.L.A.V.III.FVIVWYLFSF-v...................
A0A0Q4B2P4_9ARCH/5-64 ...d-DHSH.C.LYCGDPI...P...Y.....G..R....EY..C.D...DECRvlRD...Yd...eR....TER......K.K.D.R.R...F...Y..ILV.A.V.S.LVA.VLA--------aggla...............
F0T643_METLA/3-61 ...d-QHKH.C.PVCQKPI...P...L.....S..E....RF..C.S...PKCE..QI...Y.....M....ERQ......N.K.V.A.K...T...K..KTL.Y.V.L.FAA.FIIIWLLF---tlr.................
A0A6I6G4I6_9BACT/4-49 ..tl---KQ.C.LSCGKPI...Kg.rI.....D..K....KF..C.D...DYCR..TQ...Y.....N....NQL......K.-.-.-.-...-...-..---.-.-.-.---.-----------aedtavikkina........
A0A4R3KM12_9SPHI/5-55 ahtp---KH.C.EHCGKTI...Kg.rT.....D..K....RF..C.N...DDCR..NN...F.....N....RKK......R.K.K.R.A...-...-..---.-.-.-.---.-----------leapetiaeii.........
N6VPI4_9ARCH/6-64 ...a-QHAH.C.QICGKAV...P...V.....T..E....TL..C.S...EECK..QK...Y.....Q....ALM......K.K.R.K.W...Y...L..YIM.Y.G.A.IFF.VMIIFIL----qtgi................
A0A0D4CKB1_LIMMU/1-54 ..mk-----.C.PHCKTPL...K...A.....H..E....KI..C.A...-KCG..HT...V.....K....TAR......Q.K.-.R.R...R...D..LIL.A.G.L.LLM.RLLLTIGLT--fk..................
A0A315XQQ1_9EURY/4-62 ...d-PHKH.C.PICGTPI...P...L.....N..E....LV..C.S...PDCQ..KV...W.....D....ARL......N.Q.R.K.R...S...Q..IIL.Y.V.V.IAI.FLIIWAIMTF-m...................
A0A076GXJ0_9SYNE/59-99 ..dt---RA.C.VVCGTSF...ElanP.....R..K....QT..C.S...DRCR..QQ...L.....S....RKK......R.D.-.-.-...-...-..---.-.-.-.---.-----------erawe...............
A0A081NT18_9BACL/12-76 .afq---RH.C.SHCGTII...Q...Ht...vE..E....KFelL.S...EAVE..KA...L.....K....KER......Q.K.R.K.K...K...RrvKML.I.G.I.VII.LLAVYVGVK--sv..................
A0A1Y4F259_9FIRM/74-116 .pdf---KI.C.PVCGGAV...P...A.....D..G....RMayC.S...ESCA..RI...A.....L....RRQ......K.R.D.-.-...-...-..---.-.-.-.---.-----------ymrkkr..............
D7DR63_METV3/2-60 ....EQHKH.C.INCGISI...P...P.....E..E....DF..C.S...TKCK..EE...F.....A....KRR......K.K.M.L.R...S...Q..LLM.F.G.A.FVI.VFGALILS---kym.................
U6EBV4_9EURY/3-61 ....EQHKH.C.PMCGKPI...P...L.....S..E....RF..C.S...PDCE..QL...A.....L....ANQ......K.K.V.Q.K...T...R..KML.Y.A.L.FAI.LILVWLFFV--lr..................
A0A345J5B7_9PROT/1-30 ...m---SH.C.PFCKKKI...A...M.....S..K....AF..C.S...RSCK..EN...Y.....F....---......-.-.-.-.-...-...-..---.-.-.-.---.-----------qli.................
A0A3D9H8A4_9FLAO/1-42 ...m-NHKQ.C.PECGNKIi.gR...I.....D..K....KF..C.S...DACR..NA...Y.....N....NRV......N.K.-.-.-...-...-..---.-.-.-.---.-----------dsknli..............
A0A8J7X8D6_9EURY/4-62 ...q-QHKH.C.IICEKAI...P...A.....D..E....KF..C.S...DRCE..SI...Y.....E....ERR......K.K.A.R.R...T...Q..WLF.Y.G.S.FAV.IIGWFLIMAF-q...................
A0A1W2CTK2_9SPHI/3-50 ..qe---KH.C.LQCGHAM...Qg.rA.....D..K....KF..C.D...DQCR..SI...Y.....N....RDQ......K.M.A.-.-...-...-..---.-.-.-.---.-----------gtayvknvnavl........
A0A1I1AXQ3_9BACT/4-44 ..ek---KH.C.LNCGNAI...Qg.rI.....D..K....KF..C.D...DQCR..NS...F.....N....NQQ......N.A.-.-.-...-...-..---.-.-.-.---.-----------lstnyi..............
A0A4S8RIK4_9FLAO/1-38 ..me---RH.C.LYCNEPI...Qg.rS.....D..K....KF..C.D...DQCR..SS...Y.....N....YNK......-.-.-.-.-...-...-..---.-.-.-.---.-----------naghs...............
A0A2P2BR39_9FIRM/2-56 ...k----T.C.KNCNNHL...D...K.....D..Q....RF..C.N...-KCG.yDT...L.....K....DDL......K.K.N.N.L...K...N..IIM.I.V.V.FIL.-VVIALVV---fsl.................
F4C0R0_METSG/1-43 ..mr-----.-.-------...-...A.....D..E....NF..C.D...ELCE..SK...Y.....K....SAQ......R.K.-.-.-...-...Q..QIM.F.I.I.FII.IMGLILILPS-i...................
A0A0Q4B680_9ARCH/6-63 ...p-QHRH.C.ANCKRAF...V...G.....E..G....RY..C.S...EECG..TT...S.....T....ADL......K.K.-.R.K...R...Q..LIF.L.Y.V.VSV.LVLIAALV---avn.................
A0A166F812_9EURY/3-61 ..dv--HKH.C.PVCGTPI...P...L.....D..E....TT..C.S...DKCQ..GV...L.....S....ERN......K.K.V.K.K...T...Q..LTL.Y.G.V.FIV.FIIIWIFVTFI....................
A0A6M1THY0_9BACT/4-51 .nse----HcC.LSCGIDI...S...Nk..riD..A....KY..C.S...DRCR..MR...Y.....R....RDQ......K.N.S.-.-...-...-..---.-.-.-.---.-----------kllnelidlf..........
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